D. Matthews

发表

Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate.

J. Bolin, D. Filman, D. Matthews, 1982, The Journal of biological chemistry.

Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. II. Environment of bound NADPH and implications for catalysis.

J. Bolin, D. Filman, D. Matthews, 1982, The Journal of biological chemistry.

Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrometry reveals evidence for a cell passage induced in-frame deletion in the spike glycoprotein that removes the furin-like cleavage site

Joanna Ellis, David A. Matthews, Maria Zambon, 2020, bioRxiv.

Enhanced cationic liposome-mediated transfection using the DNA-binding peptide μ (mu) from the adenovirus core

D. Matthews, A. Miller, S. I. Shah, 2001, Gene Therapy.

A Role for Transportin in the Nuclear Import of Adenovirus Core Proteins and DNA

D. Matthews, C. Hindley, F. J. Lawrence, 2007, Traffic.

In vitro dynamic visualization analysis of fluorescently labeled minor capsid protein IX and core protein V by simultaneous detection.

D. Matthews, D. Curiel, Masato Yamamoto, 2010, Journal of molecular biology.

Proteomics informed by transcriptomics for characterising active transposable elements and genome annotation in Aedes aegypti

D. Matthews, C. Bessant, A. Fernández-Sesma, 2017, BMC Genomics.

De novo derivation of proteomes from transcriptomes for transcript and protein identification

D. Matthews, C. Bessant, G. Barker, 2012, Nature Methods.

Structure of human rhinovirus 3C protease reveals a trypsin-like polypeptide fold, RNA-binding site, and means for cleaving precursor polyprotein

D. Matthews, C. Janson, Ward W. Smith, 1994, Cell.

Conservation of Amino Acids in Human Rhinovirus 3C Protease Correlates with Broad-Spectrum Antiviral Activity of Rupintrivir, a Novel Human Rhinovirus 3C Protease Inhibitor

D. Matthews, F. Maldonado, S. Binford, 2005, Antimicrobial Agents and Chemotherapy.

Protease Inhibitor Rupintrivir , a Novel Human Rhinovirus 3 C Broad-Spectrum Antiviral Activity of Rhinovirus 3 C Protease Correlates with Conservation of Amino Acids in Human

D. Matthews, F. Maldonado, S. Binford, 1982 .

Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase.

D. Matthews, Z. Hostomska, Z. Hostomský, 1991, Science.

Real-time, portable genome sequencing for Ebola surveillance

David A. Matthews, Jared T. Simpson, C. V. Williams, 2016, Nature.

Nucleolar protein upstream binding factor is sequestered into adenovirus DNA replication centres during infection without affecting RNA polymerase I location or ablating rRNA synthesis

D. Matthews, F. J. Lawrence, B. McStay, 2006, Journal of Cell Science.

Relationship between adenovirus DNA replication proteins and nucleolar proteins B23.1 and B23.2

D. Matthews, A. Davidson, C. Hindley, 2007, The Journal of general virology.

Proteomics informed by transcriptomics for characterising differential cellular susceptibility to Nelson Bay orthoreovirus infection

Kristina L. Ford, A. Bacic, D. Matthews, 2017, BMC Genomics.

Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 6. Structure-activity studies of orally bioavailable, 2-pyridone-containing peptidomimetics.

Bo Liu, Rose Ann Ferre, Tove Tuntland, 2002, Journal of medicinal chemistry.

Structure of and kinetic channelling in bifunctional dihydrofolate reductase–thymidylate synthase

David A. Matthews, Cheryl A. Janson, D. Knighton, 1994, Nature Structural Biology.

Investigating the Influence of Ribavirin on Human Respiratory Syncytial Virus RNA Synthesis by Using a High-Resolution Transcriptome Sequencing Approach

John G Kenny, D. Matthews, C. Hertz-Fowler, 2015, Journal of Virology.

Analysis of an Ebola virus disease survivor whose host and viral markers were predictive of death indicates the effectiveness of medical countermeasures and supportive care

T. Fletcher, D. Matthews, L. Ng, 2021, Genome Medicine.

Escherichia coli thymidylate synthase: amino acid substitutions by suppression of amber nonsense mutations.

J. Miller, D. Matthews, M. Michaels, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Characterization and nucleotide binding properties of a mutant dihydropteridine reductase containing an aspartate 37-isoleucine replacement.

J. Hoch, N. Xuong, D. Matthews, 1992, The Journal of biological chemistry.

Core labeling of adenovirus with EGFP.

D. Matthews, D. Curiel, Masato Yamamoto, 2006, Virology.

Adenoviral protein V promotes a process of viral assembly through nucleophosmin 1.

D. Matthews, D. Curiel, Minghui Wang, 2012, Virology.

Zika virus infection preferentially counterbalances human peripheral monocyte and/or NK-cell activity

D. Matthews, Yongxiang Fang, L. Ng, 2017, bioRxiv.

Interpretation of nuclear magnetic resonance spectra for Lactobacillus casei dihydrofolate reductase based on the X-ray structure of the enzyme-methotrexate-NADPH complex.

D. Matthews, D A Matthews, 1979, Biochemistry.

Virus genomes reveal the factors that spread and sustained the West African Ebola epidemic

Rachel S. G. Sealfon, Pardis C Sabeti, Nuno R. Faria, 2016, bioRxiv.

High throughput discovery of protein variants using proteomics informed by transcriptomics

D. Matthews, C. Bessant, Shyamasree Saha, 2018, Nucleic acids research.

Analysis of purified Wild type and mutant adenovirus particles by SILAC based quantitative proteomics

D. Matthews, D. Curiel, K. Heesom, 2014, The Journal of general virology.

Elucidating variations in the nucleotide sequence of Ebola virus associated with increasing pathogenicity

John G Kenny, D. Matthews, N. Hall, 2014, Genome Biology.

The FDA-approved drug Alectinib compromises SARS-CoV-2 nucleocapsid phosphorylation and inhibits viral infection in vitro

Jared L. Johnson, G. Getz, J. Blenis, 2020 .

Proteolytic release and crystallization of the RNase H domain of human immunodeficiency virus type 1 reverse transcriptase.

D. Matthews, Z. Hostomska, B. Nodes, 1991, The Journal of biological chemistry.

Comparison of protein expression during wild-type, and E1B-55k-deletion, adenovirus infection using quantitative time-course proteomics

D. Matthews, K. Heesom, Vanessa C. Evans, 2017, The Journal of general virology.

Editorial: Host Innate Immune Responses to Infection by Avian- and Bat-Borne Viruses

D. Matthews, Jacqueline Smith, E. Giotis, 2021, Frontiers in Cellular and Infection Microbiology.

Nucleolar proteomics and viral infection

D. Matthews, J. Hiscox, A. Whitehouse, 2010, Proteomics.

Upstream-binding factor is sequestered into herpes simplex virus type 1 replication compartments

D. Matthews, N. Stow, Vanessa C. Evans, 2009, The Journal of general virology.

Viruses and the Nucleolus

D. Matthews, J. Hiscox, E. Emmott, 2011, The Nucleolus.

What is new in the nucleolus?: Workshop on the Nucleolus: New Perspectives

D. Matthews, M. Olson, 2006, EMBO reports.

Neuropilin-1 is a host factor for SARS-CoV-2 infection

D. Matthews, Y. Yamauchi, P. Horváth, 2020, Science.

Identification of Epstein-Barr Virus Replication Proteins in Burkitt’s Lymphoma Cells

D. Matthews, M. Rowe, A. Sinclair, 2015, Pathogens.

Precursor of human adenovirus core polypeptide Mu targets the nucleolus and modulates the expression of E2 proteins.

D. Matthews, G. Akusjärvi, G. Blair, 2004, The Journal of general virology.

Amplicon and metagenomic analysis of MERS-CoV and the microbiome in patients with severe Middle East respiratory syndrome (MERS)

J. Stewart, D. Matthews, A. Darby, 2020, bioRxiv.

Amplicon-Based Detection and Sequencing of SARS-CoV-2 in Nasopharyngeal Swabs from Patients With COVID-19 and Identification of Deletions in the Viral Genome That Encode Proteins Involved in Interferon Antagonism

Jordan J. Clark, M. Beadsworth, J. Stewart, 2020, Viruses.

Dihydrofolate reductase: x-ray structure of the binary complex with methotrexate.

N. Xuong, J. Bolin, D. Matthews, 1977, Science.

X-ray crystallographic study of boronic acid adducts with subtilisin BPN' (Novo). A model for the catalytic transition state.

D. Matthews, J. Kraut, S. Freer, 1975, The Journal of biological chemistry.

Frequent polymerase errors observed in a restricted area of clones derived from the attachment (G) protein gene of respiratory syncytial virus

D. Matthews, P. Cane, C. Pringle, 1993, Journal of virology.

Substituted benzamide inhibitors of human rhinovirus 3C protease: structure-based design, synthesis, and biological evaluation.

D. Matthews, T. Hendrickson, R. Ferre, 2000, Journal of medicinal chemistry.

Structure-based design of novel human Pin1 inhibitors (I).

Samantha Greasley, Liming Dong, D. Matthews, 2009, Bioorganic & medicinal chemistry letters.

Variation around the dominant viral genome sequence contributes to viral load and outcome in patients with Ebola virus disease

D. Matthews, S. Günther, W. Paxton, 2020, Genome biology.

Nuclear perturbations following adenovirus infection.

D. Matthews, W. Russell, D. A. Matthews, 2003, Current topics in microbiology and immunology.

The herpesvirus saimiri ORF73 gene product interacts with host-cell mitotic chromosomes and self-associates via its C terminus.

M. Calderwood, D. Matthews, A. Whitehouse, 2004, The Journal of general virology.

Tripeptide aldehyde inhibitors of human rhinovirus 3C protease: design, synthesis, biological evaluation, and cocrystal structure solution of P1 glutamine isosteric replacements.

D. Matthews, T. Hendrickson, S. Webber, 1998, Journal of medicinal chemistry.

Comparison between the interactions of adenovirus-derived peptides with plasmid DNA and their role in gene delivery mediated by liposome-peptide-DNA virus-like nanoparticles.

Andrew D. Miller, D. Matthews, I. Shah, 2003, Organic & biomolecular chemistry.

Design, synthesis, and evaluation of nonpeptidic inhibitors of human rhinovirus 3C protease.

D. Matthews, T. Hendrickson, S. Webber, 1996, Journal of medicinal chemistry.

Identification of mutations contributing to the reduced virulence of a modified strain of respiratory syncytial virus.

D. Matthews, P. Cane, J. Evans, 1996, Vaccine.

Adenovirus core protein V is delivered by the invading virus to the nucleus of the infected cell and later in infection is associated with nucleoli.

D. Matthews, W. Russell, D. A. Matthews, 1998, The Journal of general virology.

High Resolution Analysis of Respiratory Syncytial Virus Infection In Vivo

D. Matthews, S. Armstrong, J. Hiscox, 2019, Viruses.

Analysis of respiratory syncytial virus strain variation in successive epidemics in one city

D. Matthews, P. Cane, C. Pringle, 1994, Journal of clinical microbiology.

Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein

D. Matthews, M. Williamson, A. Davidson, 2020, Genome Medicine.

Direct RNA sequencing of respiratory syncytial virus infected human cells generates a detailed overview of RSV polycistronic mRNA and transcript abundance

D. Matthews, J. Hiscox, R. Fearns, 2021, bioRxiv.

Sequential infection with influenza A virus followed by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to more severe disease and encephalitis in a mouse model of COVID-19

Jordan J. Clark, J. Stewart, D. Matthews, 2020, bioRxiv.

Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 8. Pharmacological optimization of orally bioavailable 2-pyridone-containing peptidomimetics.

D. Matthews, P. Rejto, P. W. Rose, 2003, Journal of medicinal chemistry.

In Vitro Antiviral Activity of AG7088, a Potent Inhibitor of Human Rhinovirus 3C Protease

D. Matthews, M. Diem, P. Dragovich, 1999, Antimicrobial Agents and Chemotherapy.

Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes.

D. Matthews, T. Hendrickson, S. Webber, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Structure-based design of irreversible, tripeptidyl human rhinovirus 3C protease inhibitors containing N-methyl amino acids.

D. Matthews, S. Webber, P. Dragovich, 1999, Bioorganic & medicinal chemistry letters.

Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacements.

D. Matthews, P. Rejto, T. Hendrickson, 1999, Journal of medicinal chemistry.

Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics.

D. Matthews, P. Dragovich, R. Ferre, 1999, Journal of medicinal chemistry.

Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 2. Peptide structure-activity studies.

D. Matthews, R. Babine, S. Webber, 1998, Journal of medicinal chemistry.

Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 1. Michael acceptor structure-activity studies.

D. Matthews, R. Babine, S. Webber, 1998, Journal of medicinal chemistry.

Dihydrofolate reductase. The stereochemistry of inhibitor selectivity.

J M Burridge, J. Bolin, D. Filman, 1985, The Journal of biological chemistry.

Design and synthesis of novel 6,7-imidazotetrahydroquinoline inhibitors of thymidylate synthase using iterative protein crystal structure analysis.

S R Jordan, D. Matthews, C. Janson, 1992, Journal of medicinal chemistry.

Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. Part 7: structure-activity studies of bicyclic 2-pyridone-containing peptidomimetics.

Rose Ann Ferre, D. Matthews, P. Dragovich, 2002, Bioorganic & medicinal chemistry letters.

Design of thymidylate synthase inhibitors using protein crystal structures: the synthesis and biological evaluation of a novel class of 5-substituted quinazolinones.

D. Matthews, C. Janson, S. Webber, 1993, Journal of medicinal chemistry.

Design , Synthesis , and Evaluation of Nonpeptidic Inhibitors of Human Rhinovirus 3 C Protease

D. Matthews, T. Hendrickson, S. Webber, 2022 .

Structure of the Human Cytomegalovirus Protease Catalytic Domain Reveals a Novel Serine Protease Fold and Catalytic Triad

David A. Matthews, Susumu Katoh, D. Matthews, 1996, Cell.

Structure-based design of lipophilic quinazoline inhibitors of thymidylate synthase.

D. Matthews, C. Janson, K. Appelt, 1996, Journal of medicinal chemistry.

Bonding and valence electron distributions in molecules. X-ray and neutron diffraction study of the crystal and molecular structure of tetracyanoethylene oxide

D. Matthews, G. Stucky, M. Mueller, 1971 .

Bonding and valence electron distributions in molecules. Experimental determination of aspherical electron charge density in tetracyanoethylene oxide

D. Matthews, G. Stucky, 1971 .

Physical and structural basis for the strong interactions of the -ImPy- central pairing motif in the polyamide f-ImPyIm.

Karen L. Buchmueller, D. Matthews, J. Hartley, 2006, Biochemistry.

Refined crystal structures of Escherichia coli and chicken liver dihydrofolate reductase containing bound trimethoprim.

J M Burridge, C. Beddell, J. Champness, 1985, The Journal of biological chemistry.

Dihydrofolate reductase from Lactobacillus casei. Stereochemistry of NADPH binding.

N. Xuong, D. Matthews, J. Kraut, 1979, The Journal of biological chemistry.

Dihydrofolate reductase from Lactobacillus casei. X-ray structure of the enzyme methotrexate.NADPH complex.

N. Xuong, J. Bolin, D. Filman, 1978, Journal of Biological Chemistry.

Crystal structure of rat liver dihydropteridine reductase.

N. Xuong, D. Matthews, M. Skinner, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Re-examination of the charge relay system in subtilisin comparison with other serine proteases.

D. Matthews, J. Kraut, J. Birktoft, 1977, The Journal of biological chemistry.

Crystal structure of Escherichia coli thymidylate synthase containing bound 5-fluoro-2'-deoxyuridylate and 10-propargyl-5,8-dideazafolate.

N. Xuong, D. Matthews, K. Appelt, 1990, Journal of molecular biology.

Crystal structure of Escherichia coli thymidylate synthase with FdUMP and 10-propargyl-5,8-dideazafolate.

D. Matthews, K. Appelt, S. Oatley, 1989, Advances in enzyme regulation.

Stereochemical mechanism of action for thymidylate synthase based on the X-ray structure of the covalent inhibitory ternary complex with 5-fluoro-2'-deoxyuridylate and 5,10-methylenetetrahydrofolate.

D. Matthews, S. Freer, C. Janson, 1990, Journal of molecular biology.

Structural and mechanistic characteristics of dihydropteridine reductase: a member of the Tyr-(Xaa)3-Lys-containing family of reductases and dehydrogenases.

J M Whiteley, N. Xuong, D. Matthews, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Dihydropteridine Reductase

N. Xuong, D. Matthews, C. Grimshaw, 1993 .

Informed by Transcriptomics for Characterising Active Transposable Elements 1 and Genome Annotation in Aedes Aegypti 2 3 4

D. Matthews, C. Bessant, A. Davidson, 2017 .

Zika Virus Infection Preferentially Counterbalances Human Peripheral Monocyte and/or NK Cell Activity

D. Matthews, Yongxiang Fang, L. Ng, 2017, mSphere.

Quantitative proteomics using SILAC coupled to LC-MS/MS reveals changes in the nucleolar proteome in influenza A virus-infected cells.

D. Matthews, J. Hiscox, P. Digard, 2010, Journal of proteome research.

Structure-based design of ketone-containing, tripeptidyl human rhinovirus 3C protease inhibitors.

D. Matthews, S. Webber, P. Dragovich, 2000, Bioorganic & medicinal chemistry letters.

Factors affecting de novo RNA synthesis and back-priming by the respiratory syncytial virus polymerase.

D. Matthews, J. Hiscox, Waleed Aljabr, 2014, Virology.

Molecular spectroscopy by ESCA. Bonding and valence electron distribution in molecules. Experimental binding energies and charge distributions in tetracyanoethylene, tetracyanoethylene oxide, tetracyanocycylpropane, cyclopropane, ethylene oxide, and related molecules

D. Matthews, G. Stucky, C. Nordling, 1972 .

Adenovirus core protein V interacts with p32--a protein which is associated with both the mitochondria and the nucleus.

D. Matthews, W. Russell, 1998, The Journal of general virology.

PITDB: a database of translated genomic elements

Conrad Bessant, Shyamasree Saha, Eleni A. Chatzimichali, 2017, Nucleic Acids Res..

Adenovirus protein-protein interactions: hexon and protein VI.

D. Matthews, W. Russell, 1994, The Journal of general virology.

The nucleotide sequences of intergenic regions between nine genes of pneumonia virus of mice establish the physical order of these genes in the viral genome.

D. Matthews, C. Pringle, A. Easton, 1991, Virus research.

Proteomics technique opens new frontiers in mobilome research

D. Matthews, A. Davidson, Kevin Maringer, 2017, Mobile genetic elements.

The splicing factor‐associated protein, p32, regulates RNA splicing by inhibiting ASF/SF2 RNA binding and phosphorylation

D. Matthews, Svend K. Petersen-Mahrt, G. Akusjärvi, 1999, The EMBO journal.

Proteomics Analysis of the Nucleolus in Adenovirus-infected Cells

D. Matthews, Y. Lam, A. Lamond, 2009, Molecular & Cellular Proteomics.

Development and use of a 293 cell line expressing lac repressor for the rescue of recombinant adenoviruses expressing high levels of rabies virus glycoprotein.

D. Matthews, F. Graham, L. Prevec, 1999, The Journal of general virology.

Novel molecular approaches to cystic fibrosis gene therapy.

D. Matthews, G. Blair, Tim W.R. Lee, 2005, The Biochemical journal.

Adenovirus core protein VII contains distinct sequences that mediate targeting to the nucleus and nucleolus, and colocalization with human chromosomes.

D. Matthews, G. Blair, Tim W.R. Lee, 2003, The Journal of general virology.

Temporal and spatial analysis of the 2014–2015 Ebola virus outbreak in West Africa

Claudia Kohl, Andreas Nitsche, David A. Matthews, 2015, Nature.

Transcriptomic signatures differentiate survival from fatal outcomes in humans infected with Ebola virus

John G Kenny, D. Matthews, Yongxiang Fang, 2017, Genome Biology.

SARS-CoV-2 vaccine ChAdOx1 nCoV-19 infection of human cell lines reveals low levels of viral backbone gene transcription alongside very high levels of SARS-CoV-2 S glycoprotein gene transcription

D. Matthews, M. Williamson, A. Davidson, 2021, Genome medicine.

Proteomics informed by transcriptomics reveals Hendra virus sensitizes bat cells to TRAIL-mediated apoptosis

D. Matthews, K. Heesom, P. Monaghan, 2014, Genome Biology.

A comparison of host gene expression signatures associated with infection in vitro by the Makona and Ecran (Mayinga) variants of Ebola virus

John G Kenny, J. Stewart, D. Matthews, 2017, Scientific Reports.

Elucidation of the Ebola virus VP24 cellular interactome and disruption of virus biology through targeted inhibition of host-cell protein function.

D. Matthews, J. Wastling, R. Hewson, 2014, Journal of proteome research.

Amplicon based MinION sequencing of SARS-CoV-2 and metagenomic characterisation of nasopharyngeal swabs from patients with COVID-19

M. Beadsworth, D. Matthews, J. Baillie, 2020, medRxiv.

Using SILAC and quantitative proteomics to investigate the interactions between viral and host proteomes

D. Matthews, J. Barr, J. Hiscox, 2012, Proteomics.

Identification of important amino acid replacements in the 2013-2016 Ebola virus outbreak

D. Matthews, S. Lovell, D. Robertson, 2016, bioRxiv.

Identification and quantification of SARS-CoV-2 leader subgenomic mRNA gene junctions in nasopharyngeal samples shows phasic transcription in animal models of COVID-19 and dysregulation at later time points that can also be identified in humans

J. Stewart, D. Matthews, J. Baillie, 2021, bioRxiv.

Identification of variable domains of the attachment (G) protein of subgroup A respiratory syncytial viruses.

D. Matthews, P. Cane, C. Pringle, 1991, The Journal of general virology.

In Vitro Resistance Study of Rupintrivir, a Novel Inhibitor of Human Rhinovirus 3C Protease

D. Matthews, F. Maldonado, S. Binford, 2007, Antimicrobial Agents and Chemotherapy.

The Interactome of the Human Respiratory Syncytial Virus NS1 Protein Highlights Multiple Effects on Host Cell Biology

D. Matthews, J. Barr, K. Heesom, 2012, Journal of Virology.

Study of nucleolar localization of adenovirus core proteins.

D. Matthews, 2007, Methods in molecular medicine.

High-Throughput Quantitative Proteomic Analysis of Dengue Virus Type 2 Infected A549 Cells

D. Matthews, Holger Hannemann, A. Davidson, 2014, PloS one.

Mitochondrial protein p32 can accumulate in the nucleus.

D. Matthews, K. Kalland, K. Brokstad, 2001, Biochemical and biophysical research communications.

Crystal structure of a novel trimethoprim-resistant dihydrofolate reductase specified in Escherichia coli by R-plasmid R67.

D. Baccanari, D. Matthews, J. Kraut, 1986, Biochemistry.

Crystal structure of avian dihydrofolate reductase containing phenyltriazine and NADPH.

C. Hansch, D. Matthews, J. Kraut, 1982, The Journal of biological chemistry.

Inhibitor Binding to Thymidylate Synthase Is Mediated by Different Structural Determinants than Those That Promote Tight Binding to Dihydrofolate Reductase

D. Matthews, C. Janson, Ward W. Smith, 1990 .

Stacked beta-bulges in thymidylate synthase account for a novel right-handed rotation between opposing beta-sheets.

D. Matthews, K. Appelt, S. Oatley, 1989, Journal of Molecular Biology.

Role of aspartate-37 in determining cofactor specificity and binding in rat liver dihydropteridine reductase.

J. Hoch, N. Xuong, D. Matthews, 1991, Archives of biochemistry and biophysics.

A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site

N. Xuong, D. Matthews, E. Howell, 1995, Nature Structural Biology.

Genotyping coronaviruses associated with feline infectious peritonitis

D. Matthews, A. Kipar, S. Siddell, 2015, The Journal of general virology.

Deep splicing plasticity of the human adenovirus type 5 transcriptome drives virus evolution

D. Matthews, J. Hiscox, K. Leppard, 2020, Communications Biology.

The Herpesvirus Saimiri Open Reading Frame 73 Gene Product Interacts with the Cellular Protein p32

M. Calderwood, D. Matthews, A. Whitehouse, 2002, Journal of Virology.

IN VITRO ANTIVIRAL ACTIVITY OF HUMAN RHINOVIRUS 3C PROTEASE INHIBITORS AGAINST THE SARS CORONAVIRUS

D. Matthews, P. Rejto, P. W. Rose, 2004 .

Electron population analysis of accurate diffraction data. III. Application of one- and two-center formalisms to tetracyanoethylene oxide

D. Matthews, G. Stucky, P. Coppens, 1972 .

Analysis of an Ebola virus disease survivor whose host and viral markers were predictive of death indicates the effectiveness of medical countermeasures and supportive care

T. Fletcher, D. Matthews, L. Ng, 2021, Genome medicine.

Deep Sequencing of RNA from Blood and Oral Swab Samples Reveals the Presence of Nucleic Acid from a Number of Pathogens in Patients with Acute Ebola Virus Disease and Is Consistent with Bacterial Translocation across the Gut

T. Fletcher, D. Matthews, S. Günther, 2017, mSphere.

Electrostatic channeling in the bifunctional enzyme dihydrofolate reductase-thymidylate synthase.

D. Knighton, A. Elcock, J. Mccammon, 1996, Journal of molecular biology.

Deep splicing plasticity of the human adenovirus type 5 transcriptome as a driver of virus evolution

D. Matthews, J. Hiscox, K. Leppard, 2020 .

Deep splicing plasticity of the human adenovirus type 5 transcriptome as a driver of virus evolution associated software

D. Matthews, 2020 .

Adenovirus protein-protein interactions: molecular parameters governing the binding of protein VI to hexon and the activation of the adenovirus 23K protease.

D. Matthews, W. Russell, 1995, The Journal of general virology.

The furin cleavage site of SARS-CoV-2 spike protein is a key determinant for transmission due to enhanced replication in airway cells

M. Giacca, D. Matthews, Jie Zhou, 2020, bioRxiv.

Variation around the dominant viral genome sequence contributes to viral load and outcome in patients with Ebola virus disease

D. Matthews, S. Günther, W. Paxton, 2020, Genome biology.

Design and synthesis of irreversible depsipeptidyl human rhinovirus 3C protease inhibitors.

D. Matthews, B. Srinivasan, S. Webber, 2001, Bioorganic & medicinal chemistry letters.

Structure-based design of substituted diphenyl sulfones and sulfoxides as lipophilic inhibitors of thymidylate synthase.

D. Matthews, C. Janson, R. Bacquet, 1997, Journal of medicinal chemistry.

D. Matthews, P. Cane, C. Pringle, 1992, Virus research.

Structure-Based Design of Novel PIN1 Inhibitors (I)

Samantha Greasley, D. A. Matthews, R. A. Ferre, 2009 .

Proteomics informed by transcriptomics reveals Hendra virus sensitizes bat cells to TRAIL-mediated apoptosis

D. Matthews, K. Heesom, P. Monaghan, 2014, Genome Biology.

Calculation of solvation and binding free energy differences for folate-based inhibitors of the enzyme thymidylate synthase

D. Matthews, S. Freer, D. Zichi, 1992 .

Galaxy Integrated Omics: Web-based Standards-Compliant Workflows for Proteomics Informed by Transcriptomics*

Conrad Bessant, David A. Matthews, Fawaz Ghali, 2015, Molecular & Cellular Proteomics.

Elucidation of the Ebola virus VP24 cellular interactome and disruption of virus biology through targeted inhibition of host-cell protein function.

D. Matthews, J. Wastling, R. Hewson, 2014, Journal of proteome research.

Quantitative proteomics using SILAC coupled to LC-MS/MS reveals changes in the nucleolar proteome in influenza A virus-infected cells.

D. Matthews, J. Hiscox, P. Digard, 2010, Journal of proteome research.

Real-time, portable genome sequencing for Ebola surveillance

C. V. Williams, N. Loman, J. Quick, 2016, Nature.

Structure of pteridine reductase (PTR1) from Leishmania tarentolae.

M. Ouellette, D. Matthews, Ming Zhao, 2003, Acta crystallographica. Section D, Biological crystallography.

SARS-CoV-2 candidate vaccine ChAdOx1 nCoV-19 infection of human cell lines reveals a normal low range of viral backbone gene expression alongside very high levels of SARS-CoV-2 S glycoprotein expression.

D. Matthews, M. Williamson, A. Davidson, 2020 .

Quantitative proteomics using SILAC coupled to LC-MS/MS reveals changes in the nucleolar proteome in influenza A virus-infected cells.

D. Matthews, J. Hiscox, P. Digard, 2010, Journal of proteome research.

11 Ribonucleases H

D. Matthews, Z. Hostomska, Z. Hostomský, 1993 .

Factors affecting de novo RNA synthesis and back-priming by the respiratory syncytial virus polymerase.

D. Matthews, J. Hiscox, Waleed Aljabr, 2014, Virology.