D. Rappolee

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Transient stress and stress enzyme responses have practical impacts on parameters of embryo development, from IVF to directed differentiation of stem cells

Y. Xie, J. Liu, S. Proteasa, 2008, Molecular reproduction and development.

Serine-threonine kinases and transcription factors active in signal transduction are detected at high levels of phosphorylation during mitosis in preimplantation embryos and trophoblast stem cells.

W. Zhong, E. Puscheck, D. Rappolee, 2004, Reproduction.

Hypoxic stress induces, but cannot sustain trophoblast stem cell differentiation to labyrinthine placenta due to mitochondrial insufficiency.

E. Puscheck, D. Rappolee, M. Hüttemann, 2014, Stem cell research.

Developmental expression of PDGF, TGF-alpha, and TGF-beta genes in preimplantation mouse embryos.

D. Rappolee, Z. Werb, D. Mark, 1988, Science.

Novel method for studying mRNA phenotypes in single or small numbers of cells

D. Rappolee, Z. Werb, D. Mark, 1989, Journal of cellular biochemistry.

Platelet alpha-granule fibrinogen, albumin, and immunoglobulin G are not synthesized by rat and mouse megakaryocytes.

D. Rappolee, Z. Werb, J. Levin, 1990, The Journal of clinical investigation.

Basement Membrane and Repair of Injury to Peripheral Nerve: Defining a Potential Role for Macrophages, Matrix Metalloproteinases, and Tissue Inhibitor of Metalloproteinases-1

D. Rappolee, Z. Werb, J. L. Underwood, 1996, The Journal of experimental medicine.

Why AMPK agonists not known to be stressors may surprisingly contribute to miscarriage or hinder IVF/ART

E. Puscheck, D. Rappolee, E. Secor, 2018, Journal of Assisted Reproduction and Genetics.

Two-cell embryos are more sensitive than blastocysts to AMPK-dependent suppression of anabolism and stemness by commonly used fertility drugs, a diet supplement, and stress

E. Puscheck, D. Rappolee, B. Kilburn, 2017, Journal of Assisted Reproduction and Genetics.

Six post‐implantation lethal knockouts of genes for lipophilic MAPK pathway proteins are expressed in preimplantation mouse embryos and trophoblast stem cells

E. Puscheck, D. Rappolee, Fangfei Wang, 2005, Molecular reproduction and development.

pathway regulated by imprinting in early mouse embryos. Insulin-like growth factor II acts through an endogenous growth

D. Rappolee, R. Pedersen, Z. Werb, 2013 .

The Role of Growth Factors in Mammalian Pregastrulation Development

D. Rappolee, Z. Werb, 1994 .

Effects of Imprinting on Early Development of Mouse Embryos

D. Rappolee, R. Pedersen, Z. Werb, 1993 .

Secretory products of phagocytes.

D. Rappolee, Z. Werb, Zena Werb, 1988, Current opinion in immunology.

Fibroblast growth factor receptor (FGFR)-4, but not FGFR-3 is expressed in the pregnant ovary

E. Puscheck, D. Rappolee, Y. Patel, 1997, Molecular and Cellular Endocrinology.

mRNA phenotyping for studying gene expression in small numbers of cells: platelet-derived growth factor and other growth factors in wound-derived macrophages.

D. Rappolee, Z. Werb, 1990, American journal of respiratory cell and molecular biology.

Two alkaline phosphatase genes are expressed during early development in the mouse embryo.

D. Rappolee, R. Pedersen, Z. Werb, 1990, Development.

Using high throughput screens to predict miscarriages with placental stem cells and long‐term stress effects with embryonic stem cells

E. Puscheck, D. Rappolee, D. Ruden, 2022, Birth defects research.

Using Live Imaging and Fluorescence Ubiquitinated Cell Cycle Indicator Embryonic Stem Cells to Distinguish G1 Cell Cycle Delays for General Stressors like Perfluoro-Octanoic Acid and Hyperosmotic Sorbitol or G2 Cell Cycle Delay for Mutagenic Stressors like Benzo(a)pyrene.

E. Puscheck, D. Rappolee, D. Ruden, 2022, Stem cells and development.

Development and Validation of a Rex1-RFP Potency Activity Reporter Assay That Quantifies Stress-Forced Potency Loss in Mouse Embryonic Stem Cells.

E. Puscheck, D. Rappolee, N. Gomez‐Lopez, 2016, Stem cells and development.

The Phosphoinositide Kinase PIKfyve Is Vital in Early Embryonic Development

D. Rappolee, A. Shisheva, Jian-Ping Jin, 2011, The Journal of Biological Chemistry.

Effects of Gravity, Microgravity or Microgravity Simulation on Early Mammalian Development.

E. Puscheck, D. Rappolee, D. Ruden, 2018, Stem cells and development.

Wound macrophages express TGF-alpha and other growth factors in vivo: analysis by mRNA phenotyping.

M J Banda, D. Rappolee, Z. Werb, 1988, Science.

Macrophage-derived growth factors.

D. Rappolee, Z. Werb, 1992, Current topics in microbiology and immunology.

Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos.

D. Rappolee, R. Pedersen, Z. Werb, 1992, Genes & development.

Molecular biology of the stress response in the early embryo and its stem cells.

E. Puscheck, D. Rappolee, Zhongliang Jiang, 2015, Advances in experimental medicine and biology.

Shear Stress Induces Preimplantation Embryo Death That Is Delayed by the Zona Pellucida and Associated with Stress-Activated Protein Kinase-Mediated Apoptosis1

Fangfei Wang, W. Zhong, E. Puscheck, 2006, Biology of reproduction.

Expression and function of FGF-4 in peri-implantation development in mouse embryos.

D. Rappolee, Z. Werb, Z Werb, 1994, Development.

Genes for extracellular-matrix-degrading metalloproteinases and their inhibitor, TIMP, are expressed during early mammalian development.

D. Rappolee, R. Pedersen, Z. Werb, 1989, Genes & development.

Hypoxic Stress Forces Adaptive and Maladaptive Placental Stress Responses in Early Pregnancy

E. Puscheck, D. Rappolee, A. Bolnick, 2017, Birth defects research.

Departure from optimal O2 level for mouse trophoblast stem cell proliferation and potency leads to most rapid AMPK activation

E. Puscheck, D. Rappolee, Zhongliang Jiang, 2016, The Journal of reproduction and development.

Expression of transcription regulating genes in human preimplantation embryos.

D. Rappolee, E. Pergament, M. Fiddler, 1995, Human reproduction.

Stress responses at the endometrial-placental interface regulate labyrinthine placental differentiation from trophoblast stem cells.

E. Puscheck, D. Rappolee, Yufen Xie, 2013, Reproduction.

FGF is an essential regulator of the fifth cell division in preimplantation mouse embryos.

A. McMahon, D. Rappolee, J. McMahon, 1998, Developmental biology.

Stress-induced enzyme activation primes murine embryonic stem cells to differentiate toward the first extraembryonic lineage.

E. Puscheck, D. Rappolee, Sichang Zhou, 2014, Stem cells and development.

Adaptive and Pathogenic Responses to Stress by Stem Cells during Development

D. Rappolee, Yufen Xie, L. Mansouri, 2012, Cells.

SAPKγ/JNK1 and SAPKα/JNK2 mRNA transcripts are expressed in early gestation human placenta and mouse eggs, preimplantation embryos, and trophoblast stem cells

W. Zhong, E. Puscheck, D. Rappolee, 2004 .

Expression of SRY transcripts in preimplantation human embryos.

D. Rappolee, E. Pergament, M. Fiddler, 1995, American journal of medical genetics.

The Roles of Growth Factors and Their Receptors in Peri-Implantation Mouse Embryos and at the Embryomaternal Interface

D. Rappolee, Z. Werb, 1991 .

Entire mitogen activated protein kinase (MAPK) pathway is present in preimplantation mouse embryos

E. Puscheck, D. Rappolee, Fangfei Wang, 2004, Developmental dynamics : an official publication of the American Association of Anatomists.

Expression and Function of Growth Factor Ligands and Receptors in Preimplantation Mouse Embryos

D. Rappolee, R. Pedersen, Z. Werb, 1991 .

Interpreting the stress response of early mammalian embryos and their stem cells.

E. Puscheck, D. Rappolee, A. Awonuga, 2011, International review of cell and molecular biology.

Analysis of Embryonic Cartilage and Bone Induction in a Defined Culture System

D. Rappolee, Z. Werb, H. Slavkin, 1990 .

Phthalate Exposure and Long-Term Epigenomic Consequences: A Review

D. Rappolee, D. Ruden, D. Haggerty, 2020, Frontiers in Genetics.

Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting m early mouse embryos

D. Rappolee, R. Pedersen, Z. Werb, 2007 .

It's not just baby's babble/Babel: Recent progress in understanding the language of early mammalian development: A minireview

D. Rappolee, 1999, Molecular reproduction and development.

When Stresses Collide1

D. Rappolee, A. Awonuga, Yu Yang, 2013, Biology of reproduction.

Benzopyrene and Experimental Stressors Cause Compensatory Differentiation in Placental Trophoblast Stem Cells

E. Puscheck, D. Rappolee, Yufen Xie, 2010, Systems biology in reproductive medicine.

Special Issue: SBiRM: Focus on Impact of Environmental Toxicants on Reproductive Function

D. Rappolee, 2010 .

Impact of transient stress and stress enzymes on development.

D. Rappolee, 2007, Developmental biology.

Effects of SAPK/JNK inhibitors on preimplantation mouse embryo development are influenced greatly by the amount of stress induced by the media.

E. Puscheck, D. Rappolee, Y. Xie, 2006, Molecular human reproduction.

Commonly used fertility drugs, a diet supplement, and stress force AMPK-dependent block of stemness and development in cultured mammalian embryos

E. Puscheck, D. Rappolee, B. Kilburn, 2016, Journal of Assisted Reproduction and Genetics.

Toxic stress prioritizes and imbalances stem cell differentiation: implications for new biomarkers and in vitro toxicology tests

E. Puscheck, D. Rappolee, Yufen Xie, 2012, Systems biology in reproductive medicine.

Blastocyst-Derived Stem Cell Populations under Stress: Impact of Nutrition and Metabolism on Stem Cell Potency Loss and Miscarriage

E. Puscheck, D. Rappolee, Quanwen Li, 2017, Stem Cell Reviews and Reports.

Hypoxic Stress Forces Irreversible Differentiation of a Majority of Mouse Trophoblast Stem Cells Despite FGF4

E. Puscheck, D. Rappolee, N. Gomez‐Lopez, 2016, Biology of reproduction.

A Major Effect of Simulated Microgravity on Several Stages of Preimplantation Mouse Development is Lethality Associated With Elevated Phosphorylated SAPK/JNK

E. Puscheck, D. Rappolee, H. Shen, 2009, Reproductive Sciences.

Use of Hyperosmolar Stress to Measure Stress-Activated Protein Kinase Activation and Function in Human HTR Cells and Mouse Trophoblast Stem Cells

E. Puscheck, D. Rappolee, A. Trostinskaia, 2007, Reproductive Sciences.

Using hyperosmolar stress to measure biologic and stress-activated protein kinase responses in preimplantation embryos.

W. Zhong, F. Wang, E. Puscheck, 2007, Molecular human reproduction.

Increases in phosphorylation of SAPK/JNK and p38MAPK correlate negatively with mouse embryo development after culture in different media.

E. Puscheck, D. Rappolee, Fangfei Wang, 2005, Fertility and sterility.

Using Live Imaging and FUCCI Embryonic Stem Cells to Rank DevTox Risks: Adverse Growth Effects of PFOA Compared With DEP Are 26 Times Faster, 1,000 Times More Sensitive, and 13 Times Greater in Magnitude

E. Puscheck, D. Rappolee, D. Ruden, 2021, Frontiers in Toxicology.

Pipetting causes shear stress and elevation of phosphorylated stress‐activated protein kinase/jun kinase in preimplantation embryos

F. Wang, E. Puscheck, D. Rappolee, 2007, Molecular reproduction and development.

Stress induces AMPK-dependent loss of potency factors Id2 and Cdx2 in early embryos and stem cells [corrected].

E. Puscheck, D. Rappolee, E. Rings, 2013, Stem cells and development.

A single Cys706 to Phe substitution in the retinoblastoma protein causes the loss of binding to SV40 T antigen.

D. Rappolee, S. Naylor, W. Lee, 1990, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Oxygen levels that optimize TSC culture are identified by maximizing growth rates and minimizing stress.

E. Puscheck, D. Rappolee, Y. Xie, 2011, Placenta.

Determinants of Embryo Implantation: Roles of the Endometrium and Embryo in Implantation Success.

E. Puscheck, D. Rappolee, H. Abu-Soud, 2023, Reproductive sciences.

Comparison of 2, 5, and 20 % O2 on the development of post-thaw human embryos

E. Puscheck, D. Rappolee, Canquan Zhou, 2016, Journal of Assisted Reproduction and Genetics.

Using stem cell oxygen physiology to optimize blastocyst culture while minimizing hypoxic stress

E. Puscheck, D. Rappolee, Yufen Xie, 2017, Journal of Assisted Reproduction and Genetics.

Hepatocyte growth factor and its receptor are expressed in cardiac myocytes during early cardiogenesis.

D. Rappolee, A. Iyer, Y. Patel, 1996, Circulation research.

A Role for Hepatocyte Growth Factor During Early Postimplantation Growth of the Placental Lineage in Mice1

D. Rappolee, Heidi Kim, Yogesh Patel, 2000, Biology of reproduction.

Adrenaline induces chemoresistance in HT-29 colon adenocarcinoma cells.

H. Yao, D. Rappolee, Minghui Wang, 2009, Cancer genetics and cytogenetics.

FGF Ligand Family mRNA Expression Profile for Mouse Preimplantation Embryos, Early Gestation Human Placenta, and Mouse Trophoblast Stem Cells

J. Liu, W. Zhong, E. Puscheck, 2006, Molecular reproduction and development.

Expression of fibroblast growth factor receptors in peri‐implantation mouse embryos

D. Rappolee, Yogesh Patel, Daniel A. Rappolee, 1998, Molecular reproduction and development.

Benzo(a)pyrene causes PRKAA1/2‐dependent ID2 loss in trophoblast stem cells

E. Puscheck, D. Rappolee, Yufen Xie, 2010, Molecular reproduction and development.

Hyperosmolar stress induces global mRNA responses in placental trophoblast stem cells that emulate early post-implantation differentiation.

E. Puscheck, D. Rappolee, J. Liu, 2009, Placenta.

A single cell transcriptomic fingerprint of stressed premature, imbalanced differentiation of embryonic stem cells

E. Puscheck, D. Rappolee, D. Ruden, 2023, bioRxiv.

Eomesodermin, HAND1, and CSH1 proteins are induced by cellular stress in a stress‐activated protein kinase‐dependent manner

W. Zhong, E. Puscheck, D. Rappolee, 2011, Molecular reproduction and development.

Cellular stress causes reversible, PRKAA1/2-, and proteasome-dependent ID2 protein loss in trophoblast stem cells.

W. Zhong, E. Puscheck, D. Rappolee, 2010, Reproduction.

CoQ10 increases mitochondrial mass and polarization, ATP and Oct4 potency levels, and bovine oocyte MII during IVM while decreasing AMPK activity and oocyte death

E. Puscheck, D. Rappolee, H. Abu-Soud, 2017, Journal of Assisted Reproduction and Genetics.

Stress Decreases Host Viral Resistance and Increases Covid Susceptibility in Embryonic Stem Cells

E. Puscheck, D. Rappolee, D. Ruden, 2021, Stem Cell Reviews and Reports.

Stress Forces First Lineage Differentiation of Mouse Embryonic Stem Cells; Validation of a High-Throughput Screen for Toxicant Stress.

E. Puscheck, D. Rappolee, Kang Chen, 2019, Stem cells and development.

High-Throughput Screens for Embryonic Stem Cells: Stress-Forced Potency-Stemness Loss Enables Toxicological Assays

E. Puscheck, D. Rappolee, Quanwen Li, 2016 .

Acquisition of essential somatic cell cycle regulatory protein expression and implied activity occurs at the second to third cell division in mouse preimplantation embryos

E. Puscheck, D. Rappolee, Fangfei Wang, 2005, FEBS letters.

Epigenetic Reprogramming in Mice and Humans: From Fertilization to Primordial Germ Cell Development

Ashutosh Kumar Singh, D. Rappolee, D. Ruden, 2023, Cells.

Expression of transcription regulating genes in human preimplantation embryos

D. Rappolee, E. Pergament, M. Fiddler, 1995 .

IFPA Meeting 2013 Workshop Report III: maternal placental immunological interactions, novel determinants of trophoblast cell fate, dual ex vivo perfusion of the human placenta.

D. Rappolee, G. Burton, S. Hansson, 2014, Placenta.

Insulin receptor substrate‐1 is expressed at high levels in all cells of the peri‐implantation mouse embryo

E. Puscheck, D. Rappolee, E. Pergament, 1998, Molecular reproduction and development.

Expression of fibroblast growth factor receptors in peri‐implantation mouse embryos

D. Rappolee, Yogesh Patel, Kristine Jacobson, 1998, Molecular Reproduction and Development.

Basement Membrane and Repair of Injury to Peripheral Nerve: Defining a Potential Role for Macrophages, Matrix Metalloproteinases, and Tissue Inhibitor of Metalloproteinases-1

D. Rappolee, Z. Werb, J. L. Underwood, 1996, The Journal of experimental medicine.

Basement Membrane and Repair of Injury to Peripheral Nerve: Defining a Potential Role for Macrophages, Matrix Metalloproteinases, and Tissue Inhibitor of Metalloproteinases-1 Recommended Citation

D. Rappolee, Zena Werb, M. L. Fleur, 2022 .

Interpreting the stress response of early mammalian embryos and their stem cells.

E. Puscheck, D. Rappolee, Yufen Xie, 2011, International review of cell and molecular biology.

Two-cell embryos are more sensitive than blastocysts to AMPK-dependent suppression of anabolism and stemness by commonly used fertility drugs, a diet supplement, and stress

E. Puscheck, D. Rappolee, B. Kilburn, 2017, Journal of Assisted Reproduction and Genetics.

Oxygen levels that optimize TSC culture are identified by maximizing growth rates and minimizing stress.

E. Puscheck, D. Rappolee, Yufen Xie, 2011, Placenta.