P. Linsley

P. Linsley, J. Bajorath, R. Peach, 2005, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice

P. Linsley, D. Baltimore, Guizhen Sun, 2011, The Journal of experimental medicine.

MiR-21 Promotes Glioma Invasion by Targeting MMP Regulators.

T. Wurdinger, P. Linsley, S. Kesari, 2008 .

Mustering the micromanagers

L. Lim, P. Linsley, Lee P. Lim, 2007, Nature Biotechnology.

Synthetic shRNAs as potent RNAi triggers

Wei Ge, Patrick J. Paddison, Peter S Linsley, 2005, Nature Biotechnology.

Micro RNA 145 Targets the Insulin Receptor Substrate-1 and Inhibits the Growth of Colon Cancer Cells*

Renato Baserga, Laura Sepp-Lorenzino, P. Linsley, 2007, Journal of Biological Chemistry.

Noise amidst the silence: off-target effects of siRNAs?

Aimee L Jackson, Peter S Linsley, P. Linsley, 2004, Trends in genetics : TIG.

Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 ‘Slicer’ independent and can be mediated by Ago1

P. Linsley, S. Crooke, W. Lima, 2009, Nucleic acids research.

MicroRNA-like off-target transcript regulation by siRNAs is species specific.

P. Linsley, J. Burchard, S. Bartz, 2009, RNA.

Functional genomics identifies therapeutic targets for MYC-driven cancer

Aaron N. Chang, P. Linsley, M. Cleary, 2012, Proceedings of the National Academy of Sciences.

Experimental annotation of the human genome using microarray technology

R. Stoughton, G. Schimmack, Lani F. Wu, 2001, Nature.

Innate immune stimulation of whole blood reveals IFN-1 hyper-responsiveness in type 1 diabetes

Kameron B. Rodrigues, P. Linsley, D. Duffy, 2020, Diabetologia.

Gene expression changes associated with progression and response in chronic myeloid leukemia.

Hongyue Dai, Peter S Linsley, Stephen Friend, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Recent developments in DNA microarrays.

Peter S Linsley, D. Shoemaker, P. Linsley, 2002, Current opinion in microbiology.

CD28/CTLA-4 receptor structure, binding stoichiometry and aggregation during T-cell activation.

P. Linsley, J. Bajorath, R. Peach, 1995, Research in immunology.

Disease-linked microRNA-21 exhibits drastically reduced mRNA binding and silencing activity in healthy mouse liver.

P. Linsley, N. Walter, B. Bhat, 2012, RNA.

MicroRNAs and Cell Cycle Regulation

Peter S Linsley, Michael Carleton, P. Linsley, 2007, Cell cycle.

The clinical utility of inhibiting CD28‐mediated costimulation

P. Linsley, S. Nadler, 2009, Immunological reviews.

Genome-wide resources of endoribonuclease-prepared short interfering RNAs for specific loss-of-function studies

J. Schelter, P. Linsley, J. Burchard, 2007, Nature Methods.

The Cyclin-Dependent Kinase 8 (CDK8) Inhibitor DCA Promotes a Tolerogenic Chemical Immunophenotype in CD4+ T Cells via a Novel CDK8-GATA3-FOXP3 Pathway

Kaitlin J. Flynn, R. Xavier, P. Linsley, 2021, Molecular and cellular biology.

The CDK8 inhibitor DCA promotes a tolerogenic chemical immunophenotype in CD4+ T cells via a novel CDK8-GATA3-FOXP3 pathway

Kaitlin J. Flynn, R. Xavier, P. Linsley, 2019, bioRxiv.

The CDK8 inhibitor DCA promotes a tolerogenic chemical immunophenotype in CD4+ T cells via a novel CDK8-GATA3-FOXP3 pathway

Kaitlin J. Flynn, R. Xavier, P. Linsley, 2019, bioRxiv.

Cell type-specific immune phenotypes predict loss of insulin secretion in new-onset type 1 diabetes.

P. Linsley, C. Greenbaum, C. Speake, 2019, JCI insight.

Designing siRNA That Distinguish between Genes That Differ by a Single Nucleotide

J. Schelter, P. Linsley, J. Burchard, 2006, PLoS genetics.

An optimized lentivirus-mediated RNAi screen reveals kinase modulators of kinesin-5 inhibitor sensitivity.

P. Linsley, M. Cleary, Brian S. Roberts, 2008, Assay and drug development technologies.

Identification of SULF2 as a novel transcriptional target of p53 by use of integrated genomic analyses.

Aaron N. Chang, P. Linsley, M. Cleary, 2009, Cancer research.

NPGRJ_NMETH_724 241..248

P. Linsley, J. Burchard, M. Cleary, 2018 .

An Efficient and Fully Automated High-Throughput Transfection Method for Genome-Scale siRNA Screens

Kevin W. Huff, M. Ferrer, B. Strulovici, 2008, Journal of biomolecular screening.

Cytotoxic T Lymphocyte-associated Molecule-4, a High Avidity Receptor for CD80 and CD86, Contains an Intracellular Localization Motif in Its Cytoplasmic Tail (*)

Peter S. Linsley, Jeff Bradshaw, P. Linsley, 1995, The Journal of Biological Chemistry.

RNA Interference-Mediated Silencing of Mitotic Kinesin KIF14 Disrupts Cell Cycle Progression and Induces Cytokinesis Failure

Peter S. Linsley, Michael Carleton, P. Linsley, 2006, Molecular and Cellular Biology.

CD28 cross-linking augments TCR-mediated signals and costimulates superantigen responses.

P. Linsley, S. Kanner, J. Ledbetter, 1995, Journal of immunology.

Myc-regulated microRNAs attenuate embryonic stem cell differentiation

Aimee L Jackson, Peter S Linsley, P. Linsley, 2009, The EMBO journal.

Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4+ T Cells in Peripheral Blood of Subjects with Type 1 Diabetes

James A. Eddy, P. Linsley, R. Gottardo, 2017, The Journal of Immunology.

Biosynthesis of high molecular weight breast carcinoma associated mucin glycoproteins.

P. Linsley, D. Horn, J. Kallestad, 1988, The Journal of biological chemistry.

Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy

Mark R. Enstrom, P. Linsley, R. Gottardo, 2020, Nature Communications.

The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins

P. Linsley, B. Seed, A. Aruffo, 1991, The Journal of experimental medicine.

Lymphocyte activation: T-cell regulation by CTLA-4

P. Linsley, P. Golstein, 1996, Current Biology.

Detection of larger polypeptides structurally and functionally related to type I transforming growth factor.

P. Linsley, D. Twardzik, G. Todaro, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Enforcing the checkpoints: harnessing T-cell exhaustion for therapy of T1D

P. Linsley, S. A. Long, 2019, Current opinion in endocrinology, diabetes, and obesity.

Minimizing the risk of reporting false positives in large-scale RNAi screens

Nir Hacohen, Jan Ellenberg, Norbert Perrimon, 2006, Nature Methods.

Synthetic lethality of PARP inhibition in BRCA-network disrupted tumor cells is associated with interferon pathway activation and enhanced by interferon-γ

P. Linsley, M. Cleary, M. Carleton, 2012, Apoptosis.

Exhausted-like CD8+ T cell phenotypes linked to C-peptide preservation in alefacept-treated T1D subjects

P. Linsley, G. Nepom, S. A. Long, 2020, JCI insight.

Copy Number Loss of the Interferon Gene Cluster in Melanomas Is Linked to Reduced T Cell Infiltrate and Poor Patient Prognosis

Peter S. Linsley, Damien Chaussabel, Elizabeth Whalen, 2014, PloS one.

A composite immune signature parallels disease progression across T1D subjects.

P. Linsley, R. Gottardo, M. Hessner, 2019, JCI insight.

Elevated T cell levels in peripheral blood predict poor clinical response following rituximab treatment in new-onset type 1 diabetes

Scott R. Presnell, P. Linsley, K. Herold, 2018, Genes & Immunity.

Hidden reach of the micromanagers

P. Linsley, A. Jackson, 2010, BMC Biology.

Enrichment of seed-sequence motifs in siRNA screening hits

P. Linsley, A. Jackson, 2010 .

Unique antigen recognition by a herpesvirus-specific TCR-gamma delta cell.

P. Linsley, J. Bluestone, R. Sciammas, 1994, Journal of immunology.

Costimulation of T-cell activation and virus production by B7 antigen on activated CD4+ T cells from human immunodeficiency virus type 1-infected donors.

P. Linsley, J. Bradshaw, O. Haffar, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice.

P. Linsley, R. Flavell, S. Guerder, 1994, Proceedings of the National Academy of Sciences of the United States of America.

B7 costimulates proliferation of CD4-8+ T lymphocytes but is not required for the deletion of immature CD4+8+ thymocytes.

P. Linsley, J. Ledbetter, H. Teh, 1992, Journal of immunology.

Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression.

Scott R. Presnell, P. Linsley, E. James, 2019, The Journal of clinical investigation.

CD28 Receptor Crosslinking Induces Tyrosine Phosphorylation of PLCγ1

P. Linsley, J. Ledbetter, 1992 .

Costimulatory effects of T cell proliferation during infection with human T lymphotropic virus types I and II are mediated through CD80 and CD86 ligands.

P. Linsley, R. Lal, C. Dezzutti, 1996, Journal of immunology.

SUPPLEMENTAL METHODS AND EXTENDED DERIVATIONS

P. Linsley, A. Shalek, Greg Finak, 2015 .

Characterization of a CD6 ligand(s) expressed on human- and murine-derived cell lines and murine lymphoid tissues.

B. Haynes, P. Linsley, D. Patel, 1994, Cellular immunology.

Remodeling T cell compartments during anti-CD3 immunotherapy of type 1 diabetes.

P. Linsley, K. Herold, G. Nepom, 2017, Cellular immunology.

Small Interfering RNA Screens Reveal Enhanced Cisplatin Cytotoxicity in Tumor Cells Having both BRCA Network and TP53 Disruptions

Peter S. Linsley, Marc Ferrer, Stephen H. Friend, 2006, Molecular and Cellular Biology.

Small Interfering RNA Screens Reveal Enhanced Cisplatin Cytotoxicity in Tumor Cells Having both BRCA Network and TP 53 Disruptions ‡

Peter S. Linsley, Marc Ferrer, Stephen H. Friend, 2006 .

H. polygyrus: B7-independence of the secondary type 2 response.

P. Linsley, F. Finkelman, J. Urban, 1996, Experimental parasitology.

Requirement of CTLA-4 counter receptors for IL-4 but not IL-10 elevations during a primary systemic in vivo immune response.

E Claassen, P. Linsley, F. Finkelman, 1995, Journal of immunology.

Heat-stable antigen is a costimulatory molecule for CD4 T cell growth

P. Linsley, C. Janeway, A. Aruffo, 1992, The Journal of experimental medicine.

Direct linkage of epidermal growth factor to its receptor

P. Linsley, M. Wrann, C. Blifeld, 1979, Nature.

Molecular modeling of CD28 and three-dimensional analysis of residue conservation in the CD28/CD152 family.

P. Linsley, J. Bajorath, W. Metzler, 1997, Journal of molecular graphics & modelling.

Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28

K. Constantine, L. Mueller, P. Linsley, 1997, Nature Structural Biology.

Complementarity determining region 1 (CDR1)- and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1

P. Linsley, J. Bajorath, R. Peach, 1994, The Journal of experimental medicine.

Autoreactive T cell receptors with shared germline-like α chains in type 1 diabetes

Kaitlin J. Flynn, P. Linsley, V. Gersuk, 2021, JCI insight.

The Tissue Distribution o f the B7-2 Cost imulator in Mice: Abundant Express ion on Dendri t ic Cells In Situ and D u r i n g Maturat ion In Vitro

R. Steinman, P. Linsley, H. Sakuta, 2003 .

Renal Cell Carcinoma (RCC) Tumors Display Large Expansion of Double Positive (DP) CD4+CD8+ T Cells With Expression of Exhaustion Markers

P. Linsley, S. Nadler, Maochang Liu, 2018, Front. Immunol..

Binding Stoichiometry of the Cytotoxic T Lymphocyte-associated Molecule-4 (CTLA-4)

P. Linsley, J. Bajorath, J. Bradshaw, 1995, The Journal of Biological Chemistry.

Deep immune phenotyping reveals similarities between aging, Down syndrome, and autoimmunity

Kaitlin J. Flynn, P. Linsley, V. Gersuk, 2022, Science Translational Medicine.

Identification of a novel serum protein secreted by lung carcinoma cells.

P. Linsley, J. Brown, E. Tolentino, 1986, Biochemistry.

Single-chain mono- and bispecific antibody derivatives with novel biological properties and antitumour activity from a COS cell transient expression system.

H. P. Fell, J Bajorath, M. Gayle, 1994, Therapeutic immunology.

Partial exhaustion of CD8 T cells and clinical response to teplizumab in new-onset type 1 diabetes

James A. Eddy, P. Linsley, V. Gersuk, 2016, Science Immunology.

Immunosuppression and induction of anergy by CTLA4Ig in vitro: effects on cellular and antibody responses of lymphocytes from rats with experimental autoimmune myasthenia gravis.

P. Linsley, K. Mcintosh, D. Drachman, 1995, Cellular immunology.

Effect of Xpcl1 Activation and p27Kip1 Loss on Gene Expression in Murine Lymphoma

B. Clurman, P. Linsley, A. Jackson, 2011, PloS one.

Receptor remodeling and regulation in the action of epidermal growth factor.

P. Linsley, M. Wrann, C. Fox, 1982, Federation proceedings.

Soluble CTLA4Ig modifies acute rejection of rat lung allografts without blocking accumulation of key cytokine transcripts.

P. Linsley, A. Marchevsky, J. Matloff, 1995, Transplantation proceedings.

A transcriptomic reporter assay employing neutrophils to measure immunogenic activity of septic patients’ plasma

Scott R. Presnell, Matthew C. Altman, D. Chaussabel, 2014, Journal of Translational Medicine.

A genome wide analysis of ubiquitin ligases in APP processing identifies a novel regulator of BACE1 mRNA levels

Min Xu, Xiao-Ping Shi, Yuanjiang Yu, 2006, Molecular and Cellular Neuroscience.

Investigating Thymic Epithelial Cell Diversity Using Systems Biology.

P. Linsley, S. Ziegler, Honyin Chiu, 2023, Journal of immunology.

An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes.

P. Linsley, J. Bluestone, W. Russell, 2020, The New England journal of medicine.

The binding pattern of a neutralizing monoclonal antibody to mutant oncostatin M molecules is correlated with functional activity.

P. Linsley, S. Radka, M. Shoyab, 1994, Cytokine.

Bispecific receptor globulins, novel tools for the study of cellular interactions. Preparation and characterization of an E-selectin/P-selectin bispecific receptor globulin.

P. Linsley, A. Aruffo, J. Ledbetter, 1993, Journal of immunological methods.

B lymphocyte alterations accompany abatacept resistance in new-onset type 1 diabetes.

P. Linsley, C. Greenbaum, C. Speake, 2019, JCI insight.

Signatures of environmental exposures using peripheral leukocyte gene expression: tobacco smoke.

S. Friend, J. Potter, J. Radich, 2004, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Pcsk9 Deletion Promotes Murine Nonalcoholic Steatohepatitis and Hepatic Carcinogenesis: Role of Cholesterol

P. Linsley, V. Gersuk, M. Yeh, 2021, Hepatology communications.

Disulfide bond assignment and identification of regions required for functional activity of oncostatin M.

P. Linsley, M. Shoyab, J. Kallestad, 1991, The Journal of biological chemistry.

Donor-specific transfusions enhance the immunosuppressive effects of single-dose cyclosporine A and CTLA4-Ig but do not result in long-term graft acceptance in a histoincompatible model of rat lung allograft rejection.

P. Linsley, A. Marchevsky, J. Matloff, 1996, Transplant immunology.

Human T cell-dependent B cell differentiation induced by staphylococcal superantigens.

P. Linsley, W. Stohl, J. Elliott, 1994, Journal of immunology.

Polyclonal in vitro T cell proliferation and T cell-dependent B cell differentiation supported by activated autologous B cells.

P. Linsley, W. Stohl, J. Elliott, 1994, Clinical immunology and immunopathology.

Review of CTLA4Ig use for allograft immunosuppression.

P. Linsley, S. Bolling, L. Turka, 1994, Transplantation proceedings.

The therapeutic potential of microRNA modulation.

P. Linsley, A. Jackson, 2010, Discovery medicine.

CD28 receptor crosslinking induces tyrosine phosphorylation of PLC gamma 1.

P. Linsley, J. Ledbetter, 1992, Advances in experimental medicine and biology.

Prevention of immunotoxin-induced immunogenicity by coadministration with CTLA4Ig enhances antitumor efficacy.

P. Linsley, D. Chace, B. Mixan, 1997, Journal of immunology.

Synthetic lethality of PARP inhibition in BRCA-network disrupted tumor cells is associated with interferon pathway activation and enhanced by interferon-γ

P. Linsley, M. Cleary, M. Carleton, 2012, Apoptosis.

Soluble CTLA-4 can suppress autoantibody production and elicit long term unresponsiveness in a novel transgenic model.

P. Linsley, D. Milich, J. Jones, 1994, Journal of immunology.

A transcriptomic reporter assay employing neutrophils to measure immunogenic activity of septic patients’ plasma

Scott R. Presnell, Matthew C. Altman, D. Chaussabel, 2014, Journal of Translational Medicine.

Abatacept for Delay of Type 1 Diabetes Progression in Stage 1 Relatives at Risk: A Randomized, Double-Masked, Controlled Trial

Mark S. Anderson, Darrell M. Wilson, P. Raskin, 2023, Diabetes care.

Identification of an alternatively spliced form of the murine homologue of B7.

P. Linsley, J. Ledbetter, M. Inobe, 1994, Biochemical and Biophysical Research Communications - BBRC.

Mouse L cells express a molecular complex carrying the human epitopes recognized by monoclonal antibodies 44D7 and 44H7 after DNA-mediated gene transfer.

P. Linsley, M. Letarte, E. Quackenbush, 1986, Journal of immunology.

Identification of the EGF receptor on 3T3 cells by surface‐specific iodination and gel electrophoresis

P. Linsley, C. Fox, Michael Wrann, 1979, FEBS letters.

Hormone-induced modification of EGF receptor proteolysis in the induction of EGF action.

P. Linsley, R. Vale, M. Wrann, 1979, Journal of supramolecular structure.

CD80 Costimulation Is Essential for the Induction of Airway Eosinophilia

Robert Peach, Peter S. Linsley, Franca Ronchese, 1997, The Journal of experimental medicine.

Costimulation via vascular cell adhesion molecule-1 induces in T cells increased responsiveness to the CD28 counter-receptor B7.

P. Linsley, H. Ochs, A. Aruffo, 1993, Cellular immunology.

PTPN22 R620W gene editing in T cells enhances low-avidity TCR responses

P. Linsley, D. Rawlings, K. Cerosaletti, 2022, bioRxiv.

Differential effects of B7-1 blockade in the rat experimental autoimmune encephalomyelitis model.

P. Linsley, S. Khoury, R. Peach, 1997, Journal of immunology.

PHYSICAL CHARACTERIZATION AND EGF-INDUCED PHOSPHORYLATION OF DETERGENT SOLUBLE AND INSOLUBLE EGF RECEPTORS

P. Linsley, C. Fox, 1981 .

Pillars article: long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature. 1996. 381: 434-438. 1996.

P. Linsley, A. Aruffo, C. Larsen, 2011, Journal of immunology.

Differential regulation of proto-oncogenes c-jun and c-fos in T lymphocytes activated through CD28.

P. Linsley, G. Mize, D. Morris, 1994, Journal of immunology.

CTLA-4 is a second receptor for the B cell activation antigen B7

P. Linsley, J. Ledbetter, N. Damle, 1991, The Journal of experimental medicine.

IRF5 genetic risk variants drive myeloid-specific IRF5 hyper-activation and pre-symptomatic SLE.

P. Gregersen, P. Linsley, B. Barnes, 2019, JCI insight.

Complexity-Reduced Tumor Classification System using Microarray Gene Expression Dataset

Allam Appa Rao, O. Naga Raju, A. A. Rao, 2013 .

Synergism of CTLA4-IG and anti-CD4 monoclonal antibody treatment in a rat kidney transplant model.

P. Linsley, H. Volk, P. Reinke, 1997, Transplantation proceedings.

Elevated T cell levels in peripheral blood predict poor clinical response following rituximab treatment in new-onset type 1 diabetes

Scott R. Presnell, P. Linsley, K. Herold, 2018, Genes & Immunity.

Responders to low-dose ATG induce CD4+ T cell exhaustion in type 1 diabetes

P. Linsley, C. Mathews, V. Gersuk, 2023, JCI insight.

Responders to low-dose ATG induce CD4 + T cell exhaustion in type 1 diabetes

P. Linsley, C. Mathews, V. Gersuk, 2023 .

DCA promotes a novel tolerogenic program in CD 4 + T cells by inhibiting CDK 8

Kaitlin J. Flynn, R. Xavier, P. Linsley, 2019 .

CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2

P. Linsley, L. Turka, M. Sayegh, 1995, The Journal of experimental medicine.

Coordinated regulation of cell cycle transcripts by p53-Inducible microRNAs, miR-192 and miR-215.

Aaron N. Chang, P. Linsley, M. Cleary, 2008, Cancer research.

Cell type-specific immune phenotypes predict loss of insulin secretion in new-onset type 1 diabetes.

P. Linsley, C. Greenbaum, C. Speake, 2019, JCI insight.

The clinical utility of inhibiting CD28‐mediated costimulation

P. Linsley, S. Nadler, 2009, Immunological reviews.

Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells

P. Linsley, K. Shokat, M. Cooke, 1994, The Journal of experimental medicine.

Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes.

P. Linsley, N. Morgan, S. Richardson, 2018, JCI insight.

Transient immunomodulation with anti-CD40 ligand antibody and CTLA4Ig enhances persistence and secondary adenovirus-mediated gene transfer into mouse liver.

A. Gown, P. Linsley, M. Kay, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Affinity Labeling of Hormone Receptors and Other Ligand Binding Proteins

P. Linsley, M. Das, C. Fox, 1981 .

Disease-linked microRNA-21 exhibits drastically reduced mRNA binding and silencing activity in healthy mouse liver.

P. Linsley, N. Walter, B. Bhat, 2012, RNA.