B. Semler

B. Semler, H. Müller, H. Krauss, 1987, Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology.

Picornavirus Cellular Remodeling: Doubling Down in Response to Viral-Induced Inflammation

B. Semler, A. Bouin, 2020, Current Clinical Microbiology Reports.

Factors affecting the detection of enteroviruses in cerebrospinal fluid with coxsackievirus B3 and poliovirus 1 cDNA probes

B. Semler, E. Wimmer, M. Levin, 1985, Journal of clinical microbiology.

Alternative polyadenylation signals in the 3' non-coding region of a voltage-gated potassium channel gene are major determinants of mRNA isoform expression.

A. L. Goldin, B. Semler, G. Gutman, 2008, Gene.

A novel Bcr-Abl–mTOR–eIF4A axis regulates IRES-mediated translation of LEF-1

Min Zhang, B. Semler, C. Chuah, 2014, Open Biology.

A novel Bcr-Abl – mTOR – eIF 4 A axis regulates IRES-mediated translation of LEF-1 Becky

B. Semler, C. Chuah, M. Waterman, 2014 .

Processing determinants required for in vitro cleavage of the poliovirus P1 precursor to capsid proteins

B. Semler, M. Ypma-Wong, 1987, Journal of virology.

Enterovirus persistence in cardiac cells of patients suffering from idiopathic dilated cardiomyopathy is linked to 5’ terminal genomic RNA-deleted viral populations with viral-encoded proteinase activities

B. Semler, P. Bruneval, P. Gretteau, 2019 .

Construction of a subgenomic CV-B3 replicon expressing emerald green fluorescent protein to assess viral replication of a cardiotropic enterovirus strain in cultured human cells.

B. Semler, N. Lévêque, A. Bouin, 2016, Journal of virological methods.

Structurally Distinct Elements Mediate Internal Ribosome Entry within the 5′-Noncoding Region of a Voltage-gated Potassium Channel mRNA*

B. Semler, G. Gutman, Gwendolyn M Jang, 2004, Journal of Biological Chemistry.

3CD Cleavage of the Poliovirus P1 Precursor: A Model for Complex Proteinase/Substrate Interactions

B. Semler, Xiaoyu Li, W. Blair, 1993 .

Poliovirus infection induces the co-localization of cellular protein SRp20 with TIA-1, a cytoplasmic stress granule protein

B. Semler, Kerry D. Fitzgerald, 2013, Virus Research.

Site-Directed Mutagenesis ofProteinase 3CResults ina Poliovirus Deficient inSynthesis ofViral RNA Polymerase

B. Semler, 1987 .

Viral Proteinase Requirements for the Nucleocytoplasmic Relocalization of Cellular Splicing Factor SRp20 during Picornavirus Infections

B. Semler, A. Cathcart, Amanda J. Chase, 2012, Journal of Virology.

Role for the P4 amino acid residue in substrate utilization by the poliovirus 3CD proteinase

B. Semler, W. Blair, 1991, Journal of virology.

Infectious cDNA clones of the DA strain of Theiler's murine encephalomyelitis virus

B. Semler, R. Roos, S. Stein, 1989, Journal of virology.

Proteolytic processing of poliovirus polypeptides: antibodies to polypeptide P3-7c inhibit cleavage at glutamine-glycine pairs.

B. Semler, E. Wimmer, C. Anderson, 1982, Proceedings of the National Academy of Sciences of the United States of America.

RNA-protein interactions directed by the 3' end of human rhinovirus genomic RNA

B. Semler, J. H. Nguyen, S. Todd, 1995, Journal of virology.

Enterovirus-Cardiomyocyte Interactions: Impact of Terminally Deleted Genomic RNAs on Viral and Host Functions

B. Semler, J. H. Nguyen, A. Bouin, 2022, bioRxiv.

Virology under the Microscope—a Call for Rational Discourse

Joshua R. Smith, A. Casadevall, M. Vignuzzi, 2023, mSphere.

Virology under the Microscope—a Call for Rational Discourse

Joshua R. Smith, A. Casadevall, M. Vignuzzi, 2023, Journal of virology.

Virology under the Microscope—a Call for Rational Discourse

Joshua R. Smith, A. Casadevall, M. Vignuzzi, 2023, mBio.

Allosteric Effects of Ligands and Mutations on Poliovirus RNA-Dependent RNA Polymerase

J. Lyle, K. Kirkegaard, B. Semler, 2005, Journal of Virology.

Defective Interfering RNA Viruses and the Host-Cell Response

J. Holland, B. Semler, L. Roux, 1980 .

DEFECTIVE INTERFERING VIRUS PARTICLES ATTENUATE VIRUS LETHALITY IN VIVO AND IN VITRO

J. Holland, B. Semler, L. Villarreal, 1976 .

In Memoriam John J. Holland (1929-2013): a Pioneer in Molecular Virology

B. Semler, K. Spindler, 2014, Journal of Virology.

VIRAL MUTATION IN PERSISTENT INFECTION

J. Holland, B. Semler, N. Minato, 1980 .

Human Enterovirus Nonstructural Protein 2CATPase Functions as Both an RNA Helicase and ATP-Independent RNA Chaperone

Xiaoping Zhou, B. Semler, Y. Qiu, 2015, PLoS pathogens.

Effects of TDP2/VPg Unlinkase Activity on Picornavirus Infections Downstream of Virus Translation

B. Semler, K. Caldecott, Guido Zagnoli-Vieira, 2020, Viruses.

Diverse Strategies Used by Picornaviruses to Escape Host RNA Decay Pathways

B. Semler, W. Ullmer, 2016, Viruses.

Picornaviruses and RNA Metabolism: Local and Global Effects of Infection

B. Semler, Autumn C Holmes, 2019, Journal of Virology.

Effects of mutations in poliovirus 3Dpol on RNA polymerase activity and on polyprotein cleavage

B. Semler, E. Ehrenfeld, C. Burns, 1989, Journal of virology.

Minimum internal ribosome entry site required for poliovirus infectivity

B. Semler, A. A. Haller, J. H. Nguyen, 1993, Journal of virology.

Sequence of a RNA templated by the 3'-OH RNA terminus of defective interfering particles of vesicular stomatitis virus.

J. Holland, B. Semler, J. Abelson, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Mutational analysis of the genome-linked protein VPg of poliovirus

B. Semler, E. Wimmer, R. Kuhn, 1988, Journal of virology.

Construction of a "mutagenesis cartridge" for poliovirus genome-linked viral protein: isolation and characterization of viable and nonviable mutants.

B. Semler, E. Wimmer, J. Dunn, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways

B. Semler, M. Seldin, J. Maciejowski, 2021, Nature Communications.

Molecular biology of picornaviruses

B. Semler, E. Wimmer, 2002 .

Mechanistic Consequences of hnRNP C Binding to Both RNA Termini of Poliovirus Negative-Strand RNA Intermediates

B. Semler, J. Brunner, Kenneth J. Ertel, 2010, Journal of Virology.

Neurovirulence determinants of genetically engineered Theiler viruses.

B. Semler, M. Routbort, R. Roos, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Stress-Inducible Alternative Translation Initiation of Human Cytomegalovirus Latency Protein pUL138

B. Semler, F. Goodrum, Kerry D. Fitzgerald, 2010, Journal of Virology.

Bridging IRES elements in mRNAs to the eukaryotic translation apparatus.

B. Semler, Kerry D. Fitzgerald, 2009, Biochimica et biophysica acta.

Picornaviruses and nuclear functions: targeting a cellular compartment distinct from the replication site of a positive-strand RNA virus

B. Semler, Dylan Flather, 2015, Front. Microbiol..

Structure of the PCBP2/stem–loop IV complex underlying translation initiation mediated by the poliovirus type I IRES

B. Semler, J. Wilce, H. Venugopal, 2020, Nucleic acids research.

A nucleo‐cytoplasmic SR protein functions in viral IRES‐mediated translation initiation

B. Semler, Sarah Daijogo, K. Bedard, 2007, The EMBO journal.

Poly (rC) binding protein 2 forms a ternary complex with the 5'-terminal sequences of poliovirus RNA and the viral 3CD proteinase.

B. Semler, L. Blyn, E. Ehrenfeld, 1997, RNA.

Requirement of poly(rC) binding protein 2 for translation of poliovirus RNA

B. Semler, L. Blyn, E. Ehrenfeld, 1997, Journal of virology.

Poly(rC) binding protein 2 binds to stem-loop IV of the poliovirus RNA 5' noncoding region: identification by automated liquid chromatography-tandem mass spectrometry.

B. Semler, L. Blyn, E. Ehrenfeld, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Cellular mRNA Decay Protein AUF1 Negatively Regulates Enterovirus and Human Rhinovirus Infections

B. Semler, A. Cathcart, Janet M. Rozovics, 2013, Journal of Virology.

Human Rhinovirus Infections Negatively Regulates Enterovirus and Cellular mRNA Decay Protein AUF1

B. Semler, A. Cathcart, Janet M. Rozovics, 2013 .

SARS Coronavirus nsp1 Protein Induces Template-Dependent Endonucleolytic Cleavage of mRNAs: Viral mRNAs Are Resistant to nsp1-Induced RNA Cleavage

Krishna Shankara Narayanan, B. Semler, S. Makino, 2011, PLoS pathogens.

Differential utilization of poly(rC) binding protein 2 in translation directed by picornavirus IRES elements.

B. Semler, E. Ehrenfeld, E. Ehrenfeld, 1999, RNA.

APOBEC3B drives PKR-mediated translation shutdown and protects stress granules in response to viral infection

B. Semler, M. Seldin, A. Bouin, 2023, Nature Communications.

MDA5 Detects the Double-Stranded RNA Replicative Form in Picornavirus-Infected Cells

Qian Feng, Martijn A. Langereis, B. Semler, 2012, Cell Reports.

Self-cleaving proteases.

B. Semler, W. Blair, 1991, Current opinion in cell biology.

Picornavirus Modification of a Host mRNA Decay Protein

B. Semler, J. Wilusz, S. Palusa, 2012, mBio.

The induction of allophanate lyase during the vegetative cell cycle in light-synchronized cultures of Chlamydomonas reinhardi.

B. Semler, S. Howell, R. Hodson, 1975, Biochimica et biophysica acta.

The linker domain of poly(rC) binding protein 2 is a major determinant in poliovirus cap-independent translation.

B. Semler, J. H. Nguyen, P. Sean, 2008, Virology.

Coxsackievirus B RNA replication: lessons from poliovirus.

B. Semler, P. Sean, 2008, Current topics in microbiology and immunology.

Structure, Proteolytic Processing, and Neutralization Antigenic Sites of Poliovirus

B. Semler, E. Wimmer, R. Hanecak, 1984 .

Viral Vectors for Neural Circuit Mapping and Recent Advances in Trans-synaptic Anterograde Tracers

Xiangmin Xu, Todd C. Holmes, Min-Hua Luo, 2020, Neuron.

Positive‐Strand RNA Virus Replication in Vertebrate Hosts

B. Semler, J. Brunner, 2010 .

An RNA virus hijacks an incognito function of a DNA repair enzyme

Tuan Ngo, D. Filippov, B. Semler, 2012, Proceedings of the National Academy of Sciences.

Determinants of Membrane Association for Poliovirus Protein 3AB*

B. Semler, J. Towner, T. Ho, 1996, The Journal of Biological Chemistry.

Resistance is futile

B. Semler, 2005, Nature Genetics.

Altered interactions between stem-loop IV within the 5' noncoding region of coxsackievirus RNA and poly(rC) binding protein 2: effects on IRES-mediated translation and viral infectivity.

B. Semler, J. H. Nguyen, P. Sean, 2009, Virology.

Processing of a cellular polypeptide by 3CD proteinase is required for poliovirus ribonucleoprotein complex formation

B. Semler, T. Parsley, H. Roehl, 1997, Journal of virology.

Expression of a cloned gene segment of poliovirus in E. coli: Evidence for autocatalytic production of the viral proteinase

B. Semler, E. Wimmer, H. Ariga, 1984, Cell.

An Authentic 3′ Noncoding Region Is Necessary for Efficient Poliovirus Replication

B. Semler, David M Brown, J. H. Nguyen, 2005, Journal of Virology.

Structural domains of the poliovirus polyprotein are major determinants for proteolytic cleavage at Gln-Gly pairs.

D. Filman, B. Semler, J. Hogle, 1988, The Journal of biological chemistry.

Title Viral Determinants of miR-122 Independent Hepatitis C Virus Replication Permalink

B. Semler, Benjamin Israelow, Tien-Huei Hsu, 2016 .

Modification of picornavirus genomic RNA using ‘click’ chemistry shows that unlinking of the VPg peptide is dispensable for translation and replication of the incoming viral RNA

D. Filippov, B. Semler, Gerbrand J. van der Heden van Noort, 2013, Nucleic acids research.

Genome Replication II: the Process

K. Kirkegaard, B. Semler, 2010 .

Single-tube collection and nucleic acid analysis of clinical samples for SARS-CoV-2 saliva testing

B. Semler, M. Inlay, A. Lupták, 2022, Scientific Reports.

Polyprotein processing of Theiler's murine encephalomyelitis virus

B. Semler, W. Kong, R. Roos, 1989, Journal of virology.

Host cell proteins binding to domain IV of the 5' noncoding region of poliovirus RNA

B. Semler, L. Blyn, E. Ehrenfeld, 1995, Journal of virology.

Anatomy of the poliovirus internal ribosome entry site.

B. Semler, E. Ehrenfeld, 1995, Current topics in microbiology and immunology.

Poliovirus thiol proteinase 3C can utilize a serine nucleophile within the putative catalytic triad.

B. Semler, M. Lawson, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Picornavirus Cellular Remodeling: Doubling Down in Response to Viral-Induced Inflammation

B. Semler, A. Bouin, 2020, Current Clinical Microbiology Reports.

Structure-infectivity analysis of the human rhinovirus genomic RNA 3' non-coding region.

B. Semler, S. Todd, 1996, Nucleic acids research.

Viral Determinants of miR-122-Independent C Virus Replication.

B. Semler, Benjamin Israelow, Tien-Huei Hsu, 2016 .

Requirements for RNA Replication of a Poliovirus Replicon by Coxsackievirus B3 RNA Polymerase

B. Semler, E. Ehrenfeld, Y. Bell, 1999, Journal of Virology.

Distinct Poly(rC) Binding Protein KH Domain Determinants for Poliovirus Translation Initiation and Viral RNA Replication

B. Semler, T. Parsley, E. Ehrenfeld, 2002, Journal of Virology.

Viral Determinants of miR-122-Independent Hepatitis C Virus Replication

B. Semler, Benjamin Israelow, Tien-Huei Hsu, 2015, mSphere.

A 21st Century Perspective of Poliovirus Replication

B. Semler, N. Lévêque, 2015, PLoS pathogens.

Strand-Specific RNA Synthesis Determinants in the RNA-Dependent RNA Polymerase of Poliovirus

B. Semler, R. Perera, J. Brunner, 2004, Journal of Virology.

linker pDAL : NheI pDAL ASspI XhoI : NheI pDA 2 A : ClaI pDA 3 C a HpoI

B. Semler, W. Kong, R. Roos, 2022 .

Hijacking Host Functions for Translation and RNA Replication by Enteroviruses

B. Semler, Sonia Maciejewski, 2018 .

Species-specific substrate interaction of picornavirus 3C proteinase suballelic exchange mutants.

B. Semler, B. Dasmahapatra, M. Lawson, 1990, The Journal of biological chemistry.

Expression of virus-encoded proteinases: functional and structural similarities with cellular enzymes.

B. Semler, R. Finkelstein, W. Dougherty, 1993, Microbiological reviews.

High frequency of single-base transitions and extreme frequency of precise multiple-base reversion mutations in poliovirus.

J. Holland, B. Semler, C. Giachetti, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Gene Expression and Replication of Picornaviruses

B. Semler, Christopher T. Cornell, 2006 .

Picornaviruses: Pathogenesis and Molecular Biology

B. Semler, A. Cathcart, E. Baggs, 2014 .

A cellular cofactor facilitates efficient 3CD cleavage of the poliovirus P1 precursor

B. Semler, X. Li, W. Blair, 1993, Journal of virology.

Mutations in the poliovirus 3CD proteinase S1-specificity pocket affect substrate recognition and RNA binding.

B. Semler, T. Parsley, Wade S. Blair, 1996, Virology.

Exploitation of nuclear functions by human rhinovirus, a cytoplasmic RNA virus

B. Semler, Dylan Flather, P. Gershon, 2018, PLoS pathogens.

Mammalian Polycistronic mRNAs and Disease.

B. Semler, C. Gomez, Timofey A. Karginov, 2017, Trends in genetics : TIG.

Stress-Inducible Alternative Translation Initiation of Human Cytomegalovirus Latency Protein pUL138

B. Semler, F. Goodrum, Kerry D. Fitzgerald, 2010, Journal of Virology.

Alphacoronavirus Transmissible Gastroenteritis Virus nsp1 Protein Suppresses Protein Translation in Mammalian Cells and in Cell-Free HeLa Cell Extracts but Not in Rabbit Reticulocyte Lysate

Krishna Shankara Narayanan, B. Semler, S. Makino, 2010, Journal of Virology.

Differential cleavage of IRES trans-acting factors (ITAFs) in cells infected by human rhinovirus.

B. Semler, Amanda J. Chase, 2014, Virology.