Jian Yan

发表

Coimmunization with an optimized IL15 plasmid adjuvant enhances humoral immunity via stimulating B cells induced by genetically engineered DNA vaccines expressing consensus JEV and WNV E DIII.

M. Ramanathan, Y. Kuo, B. Selling, 2009, Vaccine.

Immunogenicity of a DNA vaccine candidate for COVID-19

J. Kim, D. Weiner, Jian Yan, 2020, Nature Communications.

Highly Optimized DNA Vaccine Targeting Human Telomerase Reverse Transcriptase Stimulates Potent Antitumor Immunity

N. Sardesai, D. Weiner, Jian Yan, 2013, Cancer Immunology Research.

An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model

N. Sardesai, D. Weiner, Jian Yan, 2017, Nature Communications.

In Vivo Delivery of Synthetic Human DNA-Encoded Monoclonal Antibodies Protect against Ebolavirus Infection in a Mouse Model

N. Sardesai, D. Weiner, Jian Yan, 2018, Cell reports.

Cell Reports Resource In Vivo Delivery of Synthetic Human DNA-Encoded Monoclonal Antibodies Protect against Ebolavirus Infection in a Mouse Model

N. Sardesai, D. Weiner, Jian Yan, 2022 .

Preclinical evaluation of multi antigenic HCV DNA vaccine for the prevention of Hepatitis C virus infection

D. Weiner, Jian Yan, Xuefei Shen, 2017, Scientific Reports.

Hepatitis C virus NS3/NS4A DNA vaccine induces multiepitope T cell responses in rhesus macaques mimicking human immune responses [corrected].

N. Sardesai, D. Weiner, Jian Yan, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

Strong HCV NS3- and NS4A-specific cellular immune responses induced in mice and Rhesus macaques by a novel HCV genotype 1a/1b consensus DNA vaccine.

D. Weiner, Jian Yan, R. Draghia‐Akli, 2008, Vaccine.

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two

Manish R. Patel, Charles J. Vaske, Joe Y. Chang, 2016, Journal for Immunotherapy of Cancer.

Safe and Effective Smallpox Vaccine Development Using DNA Vaccines and In vivo Electroporation

N. Sardesai, Jian Yan, K. Broderick, 2012 .

Peripheral immunization induces functional intrahepatic Hepatitis C specific immunity following selective retention of vaccine-specific CD8 T cells by the liver

D. Weiner, Jian Yan, R. Wells, 2011, Human vaccines.

Induction of antitumor immunity in vivo following delivery of a novel HPV-16 DNA vaccine encoding an E6/E7 fusion antigen.

M. Ramanathan, D. Weiner, Jian Yan, 2009, Vaccine.

Induction of robust cellular immunity against HPV6 and HPV11 in mice by DNA vaccine encoding for E6/E7 antigen

N. Sardesai, D. Weiner, Jian Yan, 2012, Human vaccines & immunotherapeutics.

Protective immunity to H7N9 influenza viruses elicited by synthetic DNA vaccine.

N. Sardesai, J. Kim, D. Weiner, 2014, Vaccine.

Optimization of electroporation-enhanced intradermal delivery of DNA vaccine using a minimally invasive surface device.

N. Sardesai, Jian Yan, A. Bello, 2012, Human gene therapy methods.

A novel prototype device for electroporation-enhanced DNA vaccine delivery simultaneously to both skin and muscle.

N. Sardesai, D. Weiner, Jian Yan, 2011, Vaccine.

DMAb inoculation of synthetic cross reactive antibodies protects against lethal influenza A and B infections

N. Sardesai, D. Weiner, Jian Yan, 2017, npj Vaccines.

High antibody and cellular responses induced to HIV-1 clade C envelope following DNA vaccines delivered by electroporation.

N. Sardesai, D. Weiner, M. Kutzler, 2011, Vaccine.

Immunogenicity of novel consensus-based DNA vaccines against avian influenza.

D. Weiner, Jian Yan, G. Kobinger, 2007, Vaccine.

Strong HCV NS3/4a, NS4b, NS5a, NS5b-specific cellular immune responses induced in Rhesus macaques by a novel HCV genotype 1a/1b consensus DNA vaccine

N. Sardesai, D. Weiner, M. Kutzler, 2014, Human vaccines & immunotherapeutics.

Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model

D. Weiner, Jian Yan, L. Bao, 2021, bioRxiv.

Rapid development of a synthetic DNA vaccine for COVID-19

Daniel W. Kulp, J. Kim, D. Weiner, 2020 .

A Synthetic Micro-Consensus DNA Vaccine Generates Comprehensive Influenza A H3N2 Immunity and Protects Mice Against Lethal Challenge by Multiple H3N2 Viruses.

D. Weiner, Jian Yan, Ami Patel, 2018, Human gene therapy.

Intramuscular and Intradermal Electroporation of HIV-1 PENNVAX-GP® DNA Vaccine and IL-12 Is Safe, Tolerable, Acceptable in Healthy Adults

J. Kublin, N. Sardesai, D. Weiner, 2020, Vaccines.

Ubiquitin-like Molecule ISG15 Acts as an Immune Adjuvant to Enhance Antigen-specific CD8 T-cell Tumor Immunity.

D. Weiner, Jian Yan, Daniel O. Villarreal, 2015, Molecular therapy : the journal of the American Society of Gene Therapy.

Alarmin IL-33 acts as an immunoadjuvant to enhance antigen-specific tumor immunity.

D. Weiner, Jian Yan, N. Obeng-Adjei, 2014, Cancer research.

IL-33 Acts as an Immunoadjuvant to Enhance Antigen-Speci fi c Tumor Immunity

D. Weiner, Jian Yan, N. Obeng-Adjei, 2014 .

DNA vaccines targeting the encoded antigens to dendritic cells induce potent antitumor immunity in mice

Jian Yan, Bin Zhang, Yang He, 2013, BMC Immunology.

Adjuvant Screen Identifies Synthetic DNA-Encoding Flt3L and CD80 Immunotherapeutics as Candidates for Enhancing Anti-tumor T Cell Responses

Tricia T. Nguyen, Jian Yan, Neil Cooch, 2020, Frontiers in Immunology.

Protective Efficacy and Long-Term Immunogenicity in Cynomolgus Macaques by Ebola Virus Glycoprotein Synthetic DNA Vaccines

N. Sardesai, D. Weiner, Jian Yan, 2018, The Journal of infectious diseases.

Broad cross-protective anti-hemagglutination responses elicited by influenza microconsensus DNA vaccine.

N. Sardesai, J. Kim, D. Weiner, 2017, Vaccine.

DNA vaccines targeting heavy chain C-terminal fragments of Clostridium botulinum neurotoxin serotypes A, B, and E induce potent humoral and cellular immunity and provide protection from lethal toxin challenge

N. Sardesai, D. Weiner, Jian Yan, 2015, Human vaccines & immunotherapeutics.

In Vivo Delivery of a DNA-Encoded Monoclonal Antibody Protects Non-human Primates against Zika Virus

M. Beltramello, D. Weiner, Jian Yan, 2019, Molecular therapy : the journal of the American Society of Gene Therapy.

Immune Therapy Targeting E6/E7 Oncogenes of Human Papillomavirus Type 6 (HPV-6) Reduces or Eliminates the Need for Surgical Intervention in the Treatment of HPV-6 Associated Recurrent Respiratory Papillomatosis

J. Kim, D. Weiner, Jian Yan, 2020, Vaccines.

Novel synthetic plasmid and Doggybone™ DNA vaccines induce neutralizing antibodies and provide protection from lethal influenza challenge in mice

N. Sardesai, D. Weiner, Jian Yan, 2015, Human vaccines & immunotherapeutics.

Intradermal DNA vaccination enhanced by low-current electroporation improves antigen expression and induces robust cellular and humoral immune responses.

D. Weiner, Jian Yan, B. Ferraro, 2012, Human gene therapy.

Novel SIVmac DNA vaccines encoding Env, Pol and Gag consensus proteins elicit strong cellular immune responses in cynomolgus macaques.

D. Weiner, Jian Yan, Natasha Corbitt, 2009, Vaccine.

High dose of plasmid IL-15 inhibits immune responses in an influenza non-human primates immunogenicity model.

D. Weiner, M. Kutzler, Jian Yan, 2009, Virology.

An Enhanced Synthetic Multiclade DNA Prime Induces Improved Cross-Clade-Reactive Functional Antibodies when Combined with an Adjuvanted Protein Boost in Nonhuman Primates

S. Zolla-Pazner, N. Sardesai, D. Weiner, 2015, Journal of Virology.

Hepatitis C Virus NS3/NS4A DNA Vaccine Induces Multiepitope T Cell Responses in Rhesus Macaques Mimicking Human Immune Responses.

N. Sardesai, D. Weiner, Jian Yan, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

Augmentation of cellular and humoral immune responses to HPV16 and HPV18 E6 and E7 antigens by VGX-3100

N. Sardesai, J. Kim, D. Weiner, 2016, Molecular therapy oncolytics.

Electroporation of Synthetic DNA Antigens Offers Protection in Nonhuman Primates Challenged with Highly Pathogenic Avian Influenza Virus

D. Weiner, Jian Yan, Mark G. Lewis, 2009, Journal of Virology.

Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial

Michael Dallas, N. Sardesai, D. Weiner, 2015, The Lancet.

Immunotherapy Against HPV16/18 Generates Potent TH1 and Cytotoxic Cellular Immune Responses

N. Sardesai, J. Kim, D. Weiner, 2012, Science Translational Medicine.

Alteration of the Tumor Stroma Using a Consensus DNA Vaccine Targeting Fibroblast Activation Protein (FAP) Synergizes with Antitumor Vaccine Therapy in Mice

D. Weiner, Jian Yan, M. Wise, 2018, Clinical Cancer Research.

Immunogenicity of a DNA vaccine candidate for COVID-19

Daniel W. Kulp, J. Kim, D. Weiner, 2020, Nature Communications.

A Designer Cross-reactive DNA Immunotherapeutic Vaccine that Targets Multiple MAGE-A Family Members Simultaneously for Cancer Therapy

Xiaowei Xu, D. Weiner, Jian Yan, 2018, Clinical Cancer Research.

A Novel DNA Vaccine Platform Enhances Neo-antigen-like T Cell Responses against WT1 to Break Tolerance and Induce Anti-tumor Immunity.

N. Sardesai, D. Weiner, Jian Yan, 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

Human papillomavirus therapeutic vaccines: targeting viral antigens as immunotherapy for precancerous disease and cancer

N. Sardesai, Jian Yan, Jian Yan, 2013, Expert review of vaccines.

Safety and comparative immunogenicity of an HIV-1 DNA vaccine in combination with plasmid interleukin 12 and impact of intramuscular electroporation for delivery.

Donald K Carter, Ian Frank, Beryl Koblin, 2013, The Journal of infectious diseases.

HIV-1 p24gag Derived Conserved Element DNA Vaccine Increases the Breadth of Immune Response in Mice

D. Heckerman, J. Mullins, N. Sardesai, 2013, PloS one.

Immunogenicity of a novel engineered HIV-1 clade C synthetic consensus-based envelope DNA vaccine.

N. Sardesai, D. Weiner, Jian Yan, 2011, Vaccine.

Cellular immunity induced by a novel HPV18 DNA vaccine encoding an E6/E7 fusion consensus protein in mice and rhesus macaques.

D. Weiner, Jian Yan, R. Draghia‐Akli, 2008, Vaccine.

Combined effects of IL-12 and electroporation enhances the potency of DNA vaccination in macaques.

D. Weiner, Jian Yan, M. Betts, 2008, Vaccine.

Enhanced cellular immune responses elicited by an engineered HIV-1 subtype B consensus-based envelope DNA vaccine.

M. Ramanathan, D. Weiner, M. Kutzler, 2007, Molecular therapy : the journal of the American Society of Gene Therapy.

Multivalent DNA Vaccines as a Strategy to Combat Multiple Concurrent Epidemics: Mosquito-Borne and Hemorrhagic Fever Viruses

D. Weiner, Jian Yan, S. Kudchodkar, 2021, Viruses.

Induction of broad cytotoxic T cells by protective DNA vaccination against Marburg and Ebola.

Gary P Kobinger, D. Weiner, Jian Yan, 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

Safety and Immunogenicity of PENNVAX-G DNA Prime Administered by Biojector 2000 or CELLECTRA Electroporation Device With Modified Vaccinia Ankara-CMDR Boost

P. Earl, B. Moss, N. Sardesai, 2017, The Journal of infectious diseases.

Heterosubtypic Protection against Pathogenic Human and Avian Influenza Viruses via In Vivo Electroporation of Synthetic Consensus DNA Antigens

N. Sardesai, D. Weiner, M. Kutzler, 2008, PloS one.

Synergy of Immune Checkpoint Blockade with a Novel Synthetic Consensus DNA Vaccine Targeting TERT.

D. Weiner, Jian Yan, E. Masteller, 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

Comparative ability of IL-12 and IL-28B to regulate Treg populations and enhance adaptive cellular immunity.

D. Weiner, Jian Yan, Dominick J. Laddy, 2009, Blood.

Protection against Borreliella burgdorferi infection mediated by a synthetically engineered DNA vaccine

D. Weiner, Jian Yan, Neil Cooch, 2020, Human vaccines & immunotherapeutics.

Activation drives PD‐1 expression during vaccine‐specific proliferation and following lentiviral infection in macaques

D. Weiner, Jian Yan, F. Johnson, 2008, European journal of immunology.

Synthetic consensus HIV-1 DNA induces potent cellular immune responses and synthesis of granzyme B, perforin in HIV infected individuals.

N. Sardesai, J. Kim, D. Weiner, 2015, Molecular therapy : the journal of the American Society of Gene Therapy.

What the Novel H1N1 Influenza Outbreak Can Teach us about Influenza as a Bioterrorism Weapon

N. Sardesai, Jian Yan, K. Broderick, 2011 .

IL-28B/IFN-λ3 Drives Granzyme B Loading and Significantly Increases CTL Killing Activity in Macaques.

N. Sardesai, D. Weiner, Jian Yan, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

Unique Th1/Th2 Phenotypes Induced during Priming and Memory Phases by Use of Interleukin-12 (IL-12) or IL-28B Vaccine Adjuvants in Rhesus Macaques

N. Sardesai, D. Weiner, Jian Yan, 2010, Clinical and Vaccine Immunology.

Long-Term Programming of Antigen-Specific Immunity from Gene Expression Signatures in the PBMC of Rhesus Macaques Immunized with an SIV DNA Vaccine

M. Katze, N. Sardesai, D. Weiner, 2011, PloS one.

Designing consensus immunogens to break tolerance to self-antigens for cancer therapy

D. Weiner, Jian Yan, Elizabeth K Duperret, 2018, Oncotarget.

Systemic immunization with CCL27/CTACK modulates immune responses at mucosal sites in mice and macaques.

D. Weiner, M. Kutzler, Jian Yan, 2010, Vaccine.

Clinical and Immunologic Biomarkers for Histologic Regression of High-Grade Cervical Dysplasia and Clearance of HPV16 and HPV18 after Immunotherapy

N. Sardesai, J. Kim, D. Weiner, 2017, Clinical Cancer Research.

DMAb inoculation of synthetic cross reactive antibodies protects against lethal influenza A and B infections

N. Sardesai, D. Weiner, Jian Yan, 2017, npj Vaccines.

Activated CD4+CCR5+ T cells in the rectum predict increased SIV acquisition in SIVGag/Tat-vaccinated rhesus macaques

N. Sardesai, D. Weiner, Jian Yan, 2014, Proceedings of the National Academy of Sciences.

An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model

N. Sardesai, D. Weiner, Jian Yan, 2017, Nature Communications.

In vivo protection against ZIKV infection and pathogenesis through passive antibody transfer and active immunisation with a prMEnv DNA vaccine

Stephanie A Booth, Gary P Kobinger, Karuppiah Muthumani, 2016, npj Vaccines.

Active immunoprophylaxis with a synthetic DNA-encoded monoclonal anti-respiratory syncytial virus scFv-Fc fusion protein confers protection against infection and durable activity

D. Weiner, Jian Yan, Neil Cooch, 2020, Human vaccines & immunotherapeutics.

Engineered DNA Vaccination against Follicle-Stimulating Hormone Receptor Delays Ovarian Cancer Progression in Animal Models.

D. Weiner, Jian Yan, L. Montaner, 2019, Molecular therapy : the journal of the American Society of Gene Therapy.

Multivalent TB vaccines targeting the esx gene family generate potent and broad cell-mediated immune responses superior to BCG

D. Weiner, Jian Yan, Dominick J. Laddy, 2014, Human vaccines & immunotherapeutics.

Robust antibody and cellular responses induced by DNA-only vaccination for HIV.

N. Sardesai, D. Weiner, Jian Yan, 2020, JCI insight.

Immunotherapy with VGX-3100 (HPV16 and HPV18 plasmids) + INO-9012 (DNA encoding IL-12) in human papillomavirus (HPV) associated head and neck squamous cell carcinoma (HNSCCa): interim safety and immunogenicity results

D. Weiner, Jian Yan, Xuefei Shen, 2015, Journal of Immunotherapy for Cancer.

HIV-1 Env DNA Vaccine plus Protein Boost Delivered by EP Expands B- and T-Cell Responses and Neutralizing Phenotype In Vivo

N. Sardesai, D. Weiner, Jian Yan, 2013, PloS one.

Immunogenicity testing of a novel engineered HIV-1 envelope gp140 DNA vaccine construct.

M. Ramanathan, D. Weiner, Jian Yan, 2006, DNA and cell biology.

IL-28B/IFN-lambda 3 drives granzyme B loading and significantly increases CTL killing activity in macaques.

N. Sardesai, D. Weiner, Jian Yan, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

CLTA‐4 blockade in vivo promotes the generation of short‐lived effector CD8+ T cells and a more persistent central memory CD4+ T cell response

D. Weiner, Jian Yan, A. Dai, 2008, Journal of medical primatology.

Chemokine Adjuvanted Electroporated-DNA Vaccine Induces Substantial Protection from Simian Immunodeficiency Virus Vaginal Challenge

N. Sardesai, D. Weiner, M. Kutzler, 2015, Mucosal Immunology.

Novel and enhanced anti-melanoma DNA vaccine targeting the tyrosinase protein inhibits myeloid-derived suppressor cells and tumor growth in a syngeneic prophylactic and therapeutic murine model

N. Sardesai, J. Kim, D. Weiner, 2014, Cancer Gene Therapy.

Immunogenicity of novel consensus-based DNA vaccines against Hepatitis B core Antigen. (106.1)

D. Weiner, Jian Yan, N. Obeng-Adjei, 2011, The Journal of Immunology.