J. Schwartz

J. Schwartz, H. Stark, C. Ganellin, 2001, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Development of a new class of nonimidazole histamine H(3) receptor ligands with combined inhibitory histamine N-methyltransferase activity.

Holger Stark, J. Schwartz, H. Stark, 2002, Journal of medicinal chemistry.

Protean agonism at histamine H3 receptors in vitro and in vivo

J. Schwartz, H. Stark, S. Crochet, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Structural variations of 1-(4-(phenoxymethyl)benzyl)piperidines as nonimidazole histamine H3 receptor antagonists.

J. Schwartz, H. Stark, J. Arrang, 2004, Bioorganic & medicinal chemistry.

Co-localization of histamine with GABA but not with galanin in the human tuberomamillary nucleus

S. Trottier, J. Schwartz, D. Swaab, 2002, Brain Research.

D3 receptor test in vitro predicts decreased cocaine self‐administration in rats

B. Everitt, L. Parsons, S. B. Caine, 1997, Neuroreport.

Heterocyclic congeners of PD 128,907 with a partially hydrogenated benzomorpholine moiety as potential dopamine D3-receptor ligands

P. Sokoloff, J. Schwartz, H. Stark, 1999 .

The preferential dopamine D3 receptor ligand, (+)-UH232, is a partial agonist.

P. Sokoloff, J. Schwartz, C. Pilon, 1995, European journal of pharmacology.

Antipsychotics with inverse agonist activity at the dopamine D3 receptor

P. Sokoloff, J. Schwartz, F. Sautel, 2005, Journal of Neural Transmission.

Constitutive activity of the recombinant and native histamine H3 receptor

J. Schwartz, H. Stark, J. Arrang, 2003 .

Therapeutic implications of constitutive activity of receptors: the example of the histamine H3 receptor.

J. Schwartz, H. Stark, J. Arrang, 2003, Journal of neural transmission. Supplementum.

Histamine H3‐receptor‐mediated [35S]GTPγ[S] binding: evidence for constitutive activity of the recombinant and native rat and human H3 receptors

J. Schwartz, J. Arrang, F. Gbahou, 2002, British journal of pharmacology.

Application of genomics to drug design: the example of the histamine H3 receptor

J. Schwartz, H. Stark, J. Arrang, 2001, European Neuropsychopharmacology.

Opiate receptors on mesolimbic dopaminergic neurons

J. Schwartz, J. Costentin, H. Pollard, 1978, Neuroscience Letters.

Electron microscopic localization of immunoreactive enkephalinase (EC 3.4.24.11) in the neostriatum of the rat

A. Beaudet, J. Schwartz, P. Verroust, 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Characterization and inhibition of a cholecystokinin-inactivating serine peptidase

J. Schwartz, P. B. Bishop, C. Ganellin, 1996, Nature.

Molecular cloning and characterization of the rat fifth melanocortin receptor.

P. Sokoloff, J. Schwartz, J. Díaz, 1994, Biochemical and biophysical research communications.

Localization of opiate receptors and enkephalins in the rat striatum in relationship with the nigrostriatal dopaminergic system: lesion studies

J. Schwartz, H. Pollard, F. Dray, 1978, Brain Research.

Histamine Receptors in Brain

M. Bouthenet, J. Schwartz, J. Arrang, 1991 .

Role of dopamine D3 receptors in thermoregulation: a reappraisal

P. Sokoloff, J. Schwartz, S. Perachon, 2000, Neuroreport.

Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin.

J. Schwartz, T. Ouimet, C. Rose, 2002, The Biochemical journal.

Dopamine D3 receptor gene: organization, transcript variants, and polymorphism associated with schizophrenia.

J. Macher, M. Martres, P. Sokoloff, 1996, American journal of medical genetics.

Histamine receptors in brain as targets for tricyclic antidepressants

J. Schwartz, M. Garbarg, T. T. Quach, 1981 .

Opiate receptors on catecholaminergic neurones in brain

J. Schwartz, 1979, Trends in Neurosciences.

Unexpected potentiation by discriminant benzamide derivatives of stereotyped behaviours elicited by dopamine agonists in mice

J. Schwartz, J. Costentin, M. Vasse, 1985, Naunyn-Schmiedeberg's Archives of Pharmacology.

Evaluation of the abuse potential of pitolisant, a selective H3-receptor antagonist/inverse agonist, for the treatment of adult patients with narcolepsy with or without cataplexy

J. Schwartz, B. Setnik, P. Robert, 2019, Sleep.

Dopamine D3 receptor gene variants and substance abuse in schizophrenia

P. Sokoloff, J. Schwartz, M. Krebs, 1998, Molecular Psychiatry.

Effects of discriminant and non-discriminant dopamine antagonists on in vivo accumulation of 3H-N-propyl-norapomorphine in mouse striatum and tuberculum olfactorium

J. Schwartz, P. Protais, C. Gulat-Marnay, 1985, Naunyn-Schmiedeberg's Archives of Pharmacology.

Two Intracellular Signaling Pathways for the Dopamine D3 Receptor: Opposite and Synergistic Interactions with Cyclic AMP

P. Sokoloff, J. Schwartz, F. Sautel, 1997, Journal of neurochemistry.

Enkephalinase activity in rat peripheral organs.

J. Schwartz, C. Llorens, 1981, European journal of pharmacology.

Distribution of enkephalinase (membrane metalloendopeptidase, E.C. 3.4.24.11) in rat organs. Detection using a monoclonal antibody.

J. Schwartz, P. Verroust, M. Galcerán, 1988, Laboratory investigation; a journal of technical methods and pathology.

Enkephalin Dipeptidyl Carboxypeptidase (Enkephalinase) Activity: Selective Radioassay, Properties, and Regional Distribution in Human Brain

Y. Agid, J. Schwartz, B. Roques, 1982, Journal of neurochemistry.

Effect of long-term therapy with fasidotril, a mixed inhibitor of neprilysin and angiotensin-converting enzyme (ACE), on survival of rats after myocardial infarction.

J. Schwartz, J. Lecomte, C. Marie, 1999, Cardiovascular research.

Discovery of nanomolar ligands with novel scaffolds for the histamine H4 receptor by virtual screening.

J. Schwartz, N. Levoin, T. Calmels, 2017, European journal of medicinal chemistry.

Mast cell specific proteases in rat brain: changes in rats with experimental allergic encephalomyelitis

J. Schwartz, M. Garbarg, A. Rouleau, 2005, Journal of Neural Transmission.

Rat cerebral mast cells undergo phenotypic changes during development.

J. Schwartz, M. Garbarg, X. Ligneau, 1996, Brain research. Developmental brain research.

Antihypertensive effects of fasidotril, a dual inhibitor of neprilysin and angiotensin-converting enzyme, in rats and humans.

J. Schwartz, P. Boutouyrie, M. Azizi, 2000, Hypertension.

Lack of association between schizophrenia and alleles in the dopamine D3 receptor gene

P. Sokoloff, J. Schwartz, G. Sedvall, 1993, Acta psychiatrica Scandinavica.

[Gene cloning of human dopaminergic D3 receptor and identification of its chromosome].

M. Martres, J. Schwartz, B. Giros, 1990, Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie.

Mixed inhibitors of angiotensin-converting enzyme (EC 3.4.15.1) and enkephalinase (EC 3.4.24.11): rational design, properties, and potential cardiovascular applications of glycopril and alatriopril.

J. Schwartz, D. Danvy, J. Lecomte, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Two splice variants of the hypoxia‐inducible factor HIF‐1α as potential dimerization partners of ARNT2 in neurons

J. Schwartz, G. Drutel, J. Arrang, 2000, The European journal of neuroscience.

Cloning and selective expression in brain and kidney of ARNT2 homologous to the Ah receptor nuclear translocator (ARNT).

J. Schwartz, G. Drutel, J. Arrang, 1996, Biochemical and biophysical research communications.

Functional relationships between sensory nerve fibers and mast cells of dura mater in normal and inflammatory conditions

J. Schwartz, M. Garbarg, A. Rouleau, 1997, Neuroscience.

Genes encoding endothelin-converting enzyme-1 and endothelin-1 interact to influence blood pressure in women: The EVA study

J. Schwartz, F. Cambien, P. Amouyel, 2004, Journal of hypertension.

Prodynorphin mRNA expression in the rat dentate gyrus after cerebral ischemia

J. Schwartz, A. Héron, E. Traiffort, 1996, Neuropeptides.

L-histidine Decarboxylase a Marker of Histaminergic Neurons

J. Schwartz, 2007 .

Effect of long-term therapy with fasidotril , a mixed inhibitor of neprilysin and angiotensin-converting enzyme ( ACE ) , on survival of rats after 1 myocardial infarction

J. Schwartz, C. Marie, J. Bralet, 1999 .

High-affinity enkephalin-degrading peptidase in brain is increased after morphine

J. Schwartz, B. Roques, B. Malfroy, 1978, Nature.

Endorphins and endorphin receptors in striatum: relationships with dopaminergic neurons.

J. Schwartz, B. Malfroy, H. Pollard, 1978, Advances in biochemical psychopharmacology.

Diuretic and natriuretic responses in rats treated with enkephalinase inhibitors.

J. Schwartz, J. Lecomte, J. Bralet, 1990, European journal of pharmacology.

Characterisation of enkephalinase (EC 3.4.24.11) activity on various leukemic cells expressing the common acute lymphocytic leukemia antigen (CALLA)

J. Schwartz, P. Devillier, M. Arock, 1989, FEBS letters.

Localization of enkephalinase mRNA in rat brain by in situ hybridization: Comparison with immunohistochemical localization of the protein

J. Schwartz, J. Wilcox, B. Malfroy, 1989, Neuropeptides.

Labelling and exploration of the active site of enkephalinase (EC 3.4.24.11) in kidney membranes with [3H]thiorphan as ligand.

J. Schwartz, S. de la Baume, 1988, European journal of pharmacology.

Enkephalinase (EC 3.4.24.11) is highly localized to a striatonigral pathway in rat brain

J. Schwartz, P. Verroust, C. Llorens-Cortes, 1987, Neuroscience Letters.

Assessment of the role of “enkephalinase” in cholecystokinin inactivation

J. Schwartz, K. Zuzel, C. Rose, 1985, Neuroscience.

Comparison of dipeptidyl carboxypeptidase and endopeptidase activities in the three enkephalin-hydrolysing metallopeptidases: "angiotensin-converting enzyme", thermolysin and "enkephalinase".

J. Schwartz, B. Malfroy, 1985, Biochemical and biophysical research communications.

Selective protection of methionine enkephalin released from brain slices by enkephalinase inhibition.

J. Schwartz, B. Roques, M. Fournié-Zaluski, 1981, Science.

Properties variations and possible synaptic functions of "enkephalinase": a newly characterised dipeptidyl carboxypeptidase.

R. Perdrisot, J. Schwartz, B. Roques, 1980, Advances in biochemical psychopharmacology.

'Enkephalinase' is distinct from brain 'angiotensin-converting enzyme'.

R. Perdrisot, J. Schwartz, G. Patey, 1979, European journal of pharmacology.

Is 'enkephalinase' identical with 'angiotensin-converting enzymes'?

R. Perdrisot, J. Schwartz, B. Malfroy, 1979, European journal of pharmacology.

Regional distribution of a high-affinity enkephalin-degrading peptidase (‘enkephalinase’) and effects of lesions suggest localization in the vicinity of opiate receptors in brain

J. Schwartz, B. Malfroy, C. Llorens, 1979, Neuroscience Letters.

Enkephalin degradation in mouse brain studied by a new H.P.L.C. method: further evidence for the involvement of carboxydipeptidase.

R. Perdrisot, J. Schwartz, B. Roques, 1979, Life sciences.

The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice

J. Schwartz, B. Roques, J. Lecomte, 1980, Nature.

Subcellular distribution of enkephalin-dipeptidyl carboxypeptidase (enkephalinase) in rat brain

J. Schwartz, G. Patey, S. Baume, 1981, Neuroscience.

BRAIN HISTIDINE DECARBOXYLASE ACTIVITY IN PARKINSON'S DISEASE

Y. Agid, J. Schwartz, F. Javoy‐Agid, 1983, The Lancet.

3H-domperidone binding sites differ in rat striatum and pituitary

M. Martres, P. Sokoloff, J. Schwartz, 1984, Naunyn-Schmiedeberg's Archives of Pharmacology.

Histamine and histidine decarboxylase in brain stem nuclei: distribution and decrease after lesions

J. Schwartz, C. Llorens-Cortes, H. Pollard, 1978, Brain Research.

Rat climbing behavior elicited by stimulation of cerebral dopamine receptors

J. Schwartz, J. Costentin, J. Bonnet, 1984, Naunyn-Schmiedeberg's Archives of Pharmacology.

Changes in dopamine receptors in mouse striatum following morphine treatments.

J. Schwartz, J. Costentin, G. Patey, 1979, Life sciences.

RADIOIMMUNOASSAY OF METHIONINE‐AND LEUCINE‐ENKEPHALINS IN REGIONS OF RAT BRAIN AND COMPARISON WITH ENDORPHINS ESTIMATED BY A RADIORECEPTOR ASSAY

J. Schwartz, B. Roques, C. Llorens-Cortes, 1978, Journal of neurochemistry.

Cloning and expression of the mouse histamine H3 receptor: evidence for multiple isoforms

J. Schwartz, J. Arrang, A. Rouleau, 2004, Journal of neurochemistry.

Changes in Histamine H3 Receptor Responsiveness in Mouse Brain

J. Schwartz, J. Arrang, S. Morisset, 2000, Journal of neurochemistry.

Atypical neuroleptics enhance histamine turnover in brain via 5-Hydroxytryptamine2A receptor blockade.

J. Schwartz, J. Arrang, S. Morisset, 1999, The Journal of pharmacology and experimental therapeutics.

Reversible and irreversible labelling of H1- and H2 -receptors using novel [125I] probes.

M. Bouthenet, J. Schwartz, J. Palacios, 1991, Agents and actions. Supplements.

Rational design of enkephalinase inhibitors: substrate specificity of enkephalinase studied from inhibitory potency of various dipeptides.

R. Perdrisot, J. Schwartz, B. Roques, 1980, Biochemical and biophysical research communications.

Binding of 3H-Leu-enkephalin in rat striatum: partial inhibition by morphine or naloxone.

J. Schwartz, Y. Audigier, B. Malfroy-Camine, 1977, European journal of pharmacology.

A novel [125I]iodinated carboxypeptidase A substrate detects a metallopeptidase activity distinct from carboxypeptidase A in brain

J. Schwartz, E. Normant, C. Gros, 1996, Neuropeptides.

Fluorinated non-imidazole histamine H3 receptor antagonists.

J. Schwartz, H. Stark, M. Capet, 2009, Bioorganic & medicinal chemistry letters.

Discovery of Pitolisant, the First Marketed Histamine H3‐Receptor Inverse Agonist/Antagonist for Treating Narcolepsy*

J. Schwartz, H. Stark, C. Ganellin, 2018 .

N‐methyl‐d‐aspartate receptor antagonists enhance histamine neuron activity in rodent brain

J. Schwartz, J. Arrang, V. Armand, 2006, Journal of neurochemistry.

Properties of "enkephalinase" from rat kidney: comparison of dipeptidyl-carboxypeptidase and endopeptidase activities.

J. Schwartz, B. Malfroy, 1982, Biochemical and biophysical research communications.

Effect of sinorphan on plasma atrial natriuretic factor in congestive heart failure

P. Merlet, J. Schwartz, A. Castaigne, 1990, The Lancet.

Protection of atrial natriuretic factor against degradation: diuretic and natriuretic responses after in vivo inhibition of enkephalinase (EC 3.4.24.11) by acetorphan.

J. Schwartz, J. Lecomte, A. Souque, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of histamine release in rat hypothalamus and hippocampus by presynaptic galanin receptors

J. Schwartz, J. Arrang, C. Gulat-Marnay, 1991, Peptides.

Regulation of Histamine Release and Synthesis in the Brain by Muscarinic Receptors

J. Schwartz, J. Arrang, C. Gulat-Marnay, 1989, Journal of neurochemistry.

Behavioral and neurochemical profiles of discriminant benzamide derivatives. Comment

M. Martres, P. Sokoloff, J. Schwartz, 1987 .

Vasopeptidase inhibitors: an emerging class of cardiovascular drugs.

J. Schwartz, J. Bralet, 2001, Trends in pharmacological sciences.

Inhibition of Histamine Synthesis in Brain by α‐Fluoromethylhistidine, a New Irreversible Inhibitor: In Vitro and In Vivo Studies

J. Schwartz, G. Barbin, M. Garbarg, 1980, Journal of neurochemistry.

Thiorphan-induced natriuresis in volume-expanded rats: roles of endogenous atrial natriuretic factor and kinins.

J. Schwartz, J. Bralet, C. Gros, 1991, The Journal of pharmacology and experimental therapeutics.

Dissociated effects of inhibitors of enkephalin-metabolising peptidases or naloxone on various nociceptive responses.

J. Schwartz, J. Costentin, P. Chaillet, 1986, European journal of pharmacology.

Selective participation of both "enkephalinase" and aminopeptidase activities in the metabolism of endogenous enkephalins.

J. Schwartz, J. Costentin, H. Marcais-Collado, 1982, Life sciences.

Participation of both ‘enkephalinase’ and aminopeptidase activities in the metabolism of endogenous enkephalins

J. Schwartz, J. Costentin, H. Marcais-Collado, 1983, Neuroscience.

Edg‐2 in myelin‐forming cells: Isoforms, genomic mapping, and exclusion in Charcot‐Marie‐Tooth disease

S. Trottier, C. Daumas-Duport, P. Sokoloff, 1999, Glia.

Highly Potent and Selective Ligands for a New Class H3 of Histamine Receptor

J. Schwartz, J. Arrang, J. Lecomte, 1988, Investigative radiology.

Pitolisant for Daytime Sleepiness in Patients with Obstructive Sleep Apnea Who Refuse Continuous Positive Airway Pressure Treatment. A Randomized Trial

J. Pépin, J. Schwartz, M. Partinen, 2020, American Journal of Respiratory and Critical Care Medicine.

Antihypertensive activity of sinorphan

J. Schwartz, J. Lecomte, C. Gros, 1990, The Lancet.

Pitolisant for Residual Excessive Daytime Sleepiness in OSA Patients Adhering to CPAP

J. Pépin, J. Schwartz, M. Partinen, 2022, Chest.

Safety and efficacy of pitolisant on cataplexy in patients with narcolepsy: a randomised, double-blind, placebo-controlled trial

J. Schwartz, Y. Dauvilliers, K. Šonka, 2017, The Lancet Neurology.

Degradation of atrial natriuretic factor in mouse blood in vitro and in vivo: Role of enkephalinase (EC 3.4.24.11)

J. Schwartz, A. Souque, C. Gros, 1990, Neuropeptides.

Inactivation of atrial natriuretic factor in mice in vivo: crucial role of enkephalinase (EC 3.4.24.11).

J. Schwartz, A. Souque, C. Gros, 1990, European journal of pharmacology.

Pharmacological characterization of 3H-LSD binding sites in mouse brain in vivo.

J. Schwartz, A. Duchemin, T. T. Quach, 1979, Life sciences.

Characterization of 3H-domperidone binding on striatal dopamine receptors.

M. Baudry, M. Martres, J. Schwartz, 1978, Life sciences.

Identification of aminopeptidase M as an enkephalin-inactivating enzyme in rat cerebral membranes.

J. Schwartz, B. Giros, C. Gros, 1985, Biochemistry.

Guinea Pig Histamine H1 Receptor. II. Stable Expression in Chinese Hamster Ovary Cells Reveals the Interaction with Three Major Signal Transduction Pathways

J. Schwartz, R. Leurs, J. Arrang, 1994, Journal of neurochemistry.

Cerebrospinal fluid histamine levels are decreased in patients with narcolepsy and excessive daytime sleepiness of other origin

J. Schwartz, Y. Dauvilliers, C. Baumann, 2010, Journal of sleep research.

The dopamine D3 receptor and schizophrenia: pharmacological, anatomical and genetic approaches

P. Sokoloff, J. Schwartz, F. Sautel, 1995, European Neuropsychopharmacology.

Steady-state level and turnover rate of the tripeptide Tyr-Gly-Gly as indexes of striatal enkephalin release in vivo and their reduction during pentobarbital anesthesia.

J. Schwartz, C. Llorens-Cortes, C. Gros, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Ether derivatives of 3-piperidinopropan-1-ol as non-imidazole histamine H3 receptor antagonists.

J. Schwartz, H. Stark, K. Kieć‐Kononowicz, 2006, Bioorganic & medicinal chemistry.

Imidazole derivatives as a novel class of hybrid compounds with inhibitory histamine N-methyltransferase potencies and histamine hH3 receptor affinities.

J. Schwartz, H. Stark, Yuan H. Zhao, 2003, Bioorganic & medicinal chemistry.

Influence of bulky substituents on histamine h(3) receptor agonist/antagonist properties.

J. Schwartz, H. Stark, J. Arrang, 2002, Journal of medicinal chemistry.

Progress in the proxifan class: heterocyclic congeners as novel potent and selective histamine H(3)-receptor antagonists.

J. Schwartz, H. Stark, J. Arrang, 2002, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors.

J. Schwartz, P. B. Bishop, O. Peschard, 2000, Journal of medicinal chemistry.

New potent histamine H3-receptor antagonists of the amide type

J. Schwartz, H. Stark, J. Arrang, 1995 .

Characterization of histamine H3 receptors regulating acetylcholine release in rat entorhinal cortex

J. Schwartz, G. Drutel, J. Arrang, 1995, British journal of pharmacology.

Unsymmetrically substituted guanidines as potent histamine H3-receptor antagonists

J. Schwartz, H. Stark, J. Arrang, 1994 .

Acylated and alkylated histamine derivatives as new histamine H3-receptor antagonists

J. Schwartz, H. Stark, J. Arrang, 1994 .

Histaminergic pathway in rat brain evidenced by lesions of the medial forebrain bundle.

J. Féger, J. Schwartz, G. Barbin, 1974, Science.

Histamine receptors in the brain.

J. Schwartz, M. Garbarg, 1985, New England and regional allergy proceedings.

A third histamine receptor subtype: Characterisation, localisation and functions of the H3-receptor

J. Schwartz, J. Arrang, H. Pollard, 1990, Agents and Actions.

Modulation of Histamine Release and Synthesis in the Brain Mediated by α2‐Adrenoceptors

J. Schwartz, J. Arrang, C. Gulat-Marnay, 1989 .

Autoinhibition of histamine synthesis mediated by presynaptic H3-receptors

J. Schwartz, J. Arrang, M. Garbarg, 1987, Neuroscience.

Autoregulation of histamine release in brain by presynaptic H3-receptors

J. Schwartz, J. Arrang, M. Garbarg, 1985, Neuroscience.

Effect of sinorphan, an enkephalinase inhibitor, on plasma atrial natriuretic factor and sodium urinary excretion in cirrhotic patients with ascites.

J. Schwartz, R. Ardaillou, J. Lecomte, 1991, The Journal of clinical endocrinology and metabolism.

[3H]glycogenolysis in brain slices mediated by β-adrenoceptors: Comparison of physiological response and [3H]dihydroalprenolol binding parameters

J. Schwartz, A. Duchemin, T. T. Quach, 1988, Neuropharmacology.

Neprilysin II: A putative novel metalloprotease and its isoforms in CNS and testis.

J. Schwartz, P. Facchinetti, T. Ouimet, 2000, Biochemical and biophysical research communications.

A Novel Potential Metallopeptidase Derived from the Enkephalinase Gene by Alternative Splicing

J. Schwartz, B. Giros, C. Llorens-Cortes, 1990, Journal of neurochemistry.

Pharmacological properties of acetorphan, a parenterally active "enkephalinase" inhibitor.

M. Leboyer, J. Schwartz, C. Llorens-Cortes, 1986, The Journal of pharmacology and experimental therapeutics.

Enkephalinase from rat kidney. Purification, characterization, and study of substrate specificity.

J. Schwartz, B. Malfroy, 1984, Journal of Biological Chemistry.

Naloxone-reversible antidiarrheal effects of enkephalinase inhibitors.

J. Schwartz, J. Costentin, J. Lecomte, 1987, European journal of pharmacology.

Induction of dopamine D3 receptor expression as a mechanism of behavioral sensitization to levodopa.

P. Sokoloff, J. Schwartz, R. Bordet, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach to designing exopeptidase inhibitors.

J. Schwartz, P. B. Bishop, C. Ganellin, 2005, Journal of medicinal chemistry.

PROPERTIES OF ENKEPHALINASE FROM MOUSE AND HUMAN BRAIN

J. Schwartz, B. Malfroy, C. Llorens, 1981 .

Effects of acetorphan, an antidiarrhoeal enkephalinase inhibitor, on oro‐caecal and colonic transit times in healthy volunteers

J. Schwartz, S. Chaussade, J. Lecomte, 1992, Alimentary pharmacology & therapeutics.

Effects of acetorphan, an enkephalinase inhibitor, on experimental and acute diarrhoea.

J. Schwartz, J. Lecomte, P. Baumer, 1992, Gut.

Histidine decar☐ylase and histamine in discrete nuclei of rat hypothalamus and the evidence for mast-cells in the median eminence

J. Schwartz, C. Llorens-Cortes, H. Pollard, 1976, Brain Research.

Phenotypic and quantitative changes in mast cells after syngeneic unilateral lung transplantation in the rat.

J. Schwartz, N. Frossard, M. Garbarg, 1996, Clinical science.

Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin.

J. Schwartz, T. Ouimet, C. Rose, 2002, The Biochemical journal.

Acute and chronic effects of methamphetamine on tele-methylhistamine levels in mouse brain: selective involvement of the D(2) and not D(3) receptor.

P. Sokoloff, J. Schwartz, J. Arrang, 2002, The Journal of pharmacology and experimental therapeutics.

Dopaminergic Regulation of Enkephalin Release

J. Schwartz, C. Llorens-Cortes, C. Gros, 1991, Journal of neurochemistry.

Synthesis and release of histamine studied on slices from rat hypothalamus.

J. Schwartz, C. Rose, M. Verdière, 1975, European journal of pharmacology.

Histamine synthesis in the developing rat brain: Evidence for a multiple compartmentation

M. Baudry, M. Martres, J. Schwartz, 1975, Brain Research.

Increased synthesis and release of 3H-histamine in rat brain by reserpine.

J. Schwartz, H. Pollard, S. Bischoff, 1973, European journal of pharmacology.

Decreased histamine synthesis in the rat brain by hypnotics and anaesthetics

J. Schwartz, H. Pollard, S. Bischoff, 1973, The Journal of pharmacy and pharmacology.

Catabolism of 3 H-histamine in the rat brain after intracisternal administration.

J. Schwartz, H. Pollard, S. Bischoff, 1971, European journal of pharmacology.

Immunoautoradiographic localisation of enkephalinase (EC 3.4.24.11) in rat gastrointestinal tract

J. Schwartz, P. Verroust, H. Pollard, 1991, Neuropeptides.

Detection of the tripeptide Tyr‐Gly‐Gly, a putative enkephalin metabolite in brain, using a sensitive radioimmunoassay

J. Schwartz, C. Llorens-Cortes, C. Gros, 1985, FEBS letters.

Pharmacology of enkephalinase inhibitors

J. Schwartz, J. Costentin, J. Lecomte, 1985 .

Major localization of aminopeptidase M in rat brain microvessels

J. Schwartz, B. Solhonne, H. Pollard, 1987, Neuroscience.

Endogenous Enkephalins, Depression and Antidepressants

J. Schwartz, C. Llorens-Cortes, J. Costentin, 1988 .

Changes in turnover of cerebral monoamines following inhibition of enkephalin metabolism by thiorphan and bestatin.

J. Schwartz, C. Llorens-Cortes, 1984, European journal of pharmacology.

OPIATE RECEPTORS LOCALIZED PRESYNAPTICALLY ON DOPAMINERGIC AND NORADRENERGIC NEURONS IN BRAIN: RELEVANCE TO TOLERANCE AND DEPENDENCE TO OPIOIDS

J. Schwartz, H. Pollard, G. Patey, 1979 .

Histamine H3 receptor binding sites in rat brain membranes: modulations by guanine nucleotides and divalent cations.

J. Schwartz, J. Arrang, W. Schunack, 1990, European journal of pharmacology.

Histamine receptors in the brain: characterization by binding studies and biochemical effects.

J. Schwartz, J. Palacios, A. Duchemin, 1980, Advances in biochemical psychopharmacology.

Augmentation in hypothalamic histamine induced by diencephalic lesions in rats

J. Féger, J. Schwartz, M. Garbarg, 1973, Agents and Actions.

3H-Glycogen hydrolysis elicited by histamine in mouse brain slices: selective involvement of H1 receptors.

J. Schwartz, A. Duchemin, T. T. Quach, 1980, Molecular pharmacology.

Histaminergic transmission in the mammalian brain.

J. Schwartz, J. Arrang, H. Pollard, 1991, Physiological reviews.

Enzyme-catalyzed prodrug approaches for the histamine H3-receptor agonist (R)-α-methylhistamine

J. Schwartz, H. Stark, M. Garbarg, 2001 .

General construction pattern of histamine H3-receptor antagonists: change of a paradigm.

J. Schwartz, H. Stark, J. Arrang, 1998, Bioorganic & medicinal chemistry letters.

Bioavailability, antinociceptive and antiinflammatory properties of BP 2-94, a histamine H3 receptor agonist prodrug.

P. Lavie, J. Schwartz, H. Stark, 1997, The Journal of pharmacology and experimental therapeutics.

Inhibition of histamine versus acetylcholine metabolism as a mechanism of tacrine activity.

J. Schwartz, S. Morisset, E. Traiffort, 1996, European journal of pharmacology.

Modulation of pentagastrin-induced histamine release by histamine H3 receptors in the dog.

J. Schwartz, S. Bertini, M. Garbarg, 1996, Scandinavian journal of gastroenterology.

Molecular and Functional Diversity of Histamine Receptor Subtypes

J. Schwartz, G. Drutel, J. Arrang, 1995, Annals of the New York Academy of Sciences.

The histamine H3 receptor: pharmacology and potential therapeutic applications.

J. Schwartz, M. Garbarg, 1993, Annales francaises d'anesthesie et de reanimation.

S-[2-(4-imidazolyl)ethyl]isothiourea, a highly specific and potent histamine H3 receptor agonist.

J. Schwartz, J. Arrang, C. Ganellin, 1992, The Journal of pharmacology and experimental therapeutics.

Design of an Affinity Matrix for Purification of the Histamine H1 Receptor from Guinea Pig Cerebellum

J. Schwartz, M. Garbarg, M. Ruat, 1992, Journal of neurochemistry.

Histamine H3 receptors : novel ligands and responses

J. Schwartz, M. Dam, J. Arrang, 1992 .

Cloning and tissue expression of a rat histamine H2-receptor gene.

J. Schwartz, R. Leurs, J. Arrang, 1991, Biochemical and biophysical research communications.

Modulation of Histamine Synthesis and Release in Brain via Presynaptic Autoreceptors and Heteroreceptors

J. Schwartz, J. Arrang, H. Pollard, 1990, Annals of the New York Academy of Sciences.

Study of endogenous Tyr-Gly-Gly, a putative enkephalin metabolite, in mouse brain: validation of a radioimmunoassay, localisation and effects of peptidase inhibitors.

J. Schwartz, C. Llorens-Cortes, C. Gros, 1985, European journal of pharmacology.

Brain Derived Neurotrophic Factor (BDNF) gene variants association with age at onset and therapeutic response in schizophrenia

P. Sokoloff, J. Schwartz, M. Krebs, 2000, Molecular Psychiatry.

Role of brain-derived neurotrophic factor in the control of D3 receptor expression

P. Sokoloff, J. Schwartz, O. Guillin, 1999, European Neuropsychopharmacology.

Inhibition of enkephalin metabolism by, and antinociceptive activity of, bestatin, an aminopeptidase inhibitor.

J. Schwartz, J. Costentin, H. Marcais-Collado, 1983, European journal of pharmacology.

Fasting or dexamethasone treatment reduce protease content in rat lung mast cells and modulation of histamine synthesis by H3 receptors

J. Schwartz, M. Garbarg, A. Rouleau, 1994, Agents and Actions.

The endogenous tripeptide Tyr-Gly-Gly as a possible metabolite of opioid peptides in rat brain: Identification, regional distribution, effects of lesions and formation in depolarized slices

J. Schwartz, B. Giros, C. Llorens-Cortes, 1986, Peptides.

Differential recognition of "enkephalinase" and angiotensin-converting enzyme by new carboxyalkyl inhibitors.

J. Schwartz, B. Roques, M. Fournié-Zaluski, 1982, Life sciences.

Brain histamine and schizophrenia: potential therapeutic applications of H3-receptor inverse agonists studied with BF2.649.

J. Schwartz, J. Arrang, R. Parmentier, 2007, Biochemical pharmacology.

Increased in vivo binding of 3H-pimozide in mouse striatum following repeated administration of haloperidol.

M. Baudry, M. Martres, J. Schwartz, 1978, Life sciences.

Title Brain histamine and schizophrenia : potential therapeutic applications of H 3-receptor inverse agonists studied with BF 2 . 649

J. Schwartz, J. Arrang, R. Parmentier, 2007 .

Fluorescent enkephalin derivatives with biological activity.

J. Schwartz, B. Roques, J. Lecomte, 1978, Biochemical and biophysical research communications.

NEW ASYMMETRIC SYNTHESIS OF DEXECADOTRIL AND ECADOTRIL STARTING FROM A SINGLE PRECURSOR

J. Schwartz, D. Danvy, J. Lecomte, 2001 .

Studies on the structural feature of S'1 subsite of neprilysin (EC.3.4.24.11): Stereochemical requirement for the enzyme-inhibitor docking process

J. Schwartz, D. Danvy, J. Lecomte, 1996 .

Histamine and tele-methylhistamine quantification in cerebrospinal fluid from narcoleptic subjects by liquid chromatography tandem mass spectrometry with precolumn derivatization.

J. Schwartz, Y. Dauvilliers, M. Croyal, 2011, Analytical biochemistry.

Histamine H2 receptor gene variants: lack of association with schizophrenia

J. Schwartz, M. Krebs, H. Lôo, 2000, Molecular Psychiatry.

The guinea pig histamine H2 receptor: gene cloning, tissue expression and chromosomal localization of its human counterpart.

J. Schwartz, E. Souil, J. Tardivel-Lacombe, 1995, Biochemical and biophysical research communications.

Endogenous histamine induces c‐fos expression within paraventricular and supraoptic nuclei

J. Schwartz, N. Griffon, A. Héron, 1995, Neuroreport.

Expression of a cloned rat histamine H2 receptor mediating inhibition of arachidonate release and activation of cAMP accumulation.

J. Schwartz, R. Leurs, D. Piomelli, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Modulation of Histamine Release in the Rat Brain by K‐Opioid Receptors

J. Schwartz, J. Arrang, A. Lafitte, 1990, Journal of neurochemistry.

Modulation of histamine release and synthesis in the brain mediated by alpha 2-adrenoceptors.

J. Schwartz, J. Arrang, A. Lafitte, 1989, Journal of neurochemistry.

Synergism between histamine H1- and H2-receptors in the cAMP response in guinea pig brain slices: effects of phorbol esters and calcium.

J. Schwartz, M. Garbarg, 1988, Molecular pharmacology.

Turnover of cerebral histamine in a stressful situation

J. Schwartz, C. Rose, M. Verdière, 1977, Brain Research.

H1 and H2 receptors in the histamine-induced accumulation of cyclic AMP in guinea pig brain slices

M. Baudry, M. Martres, J. Schwartz, 1975, Nature.

Turnover of histamine in rat brain and its decrease under barbiturate anesthesia.

J. Schwartz, H. Pollard, S. Bischoff, 1974, The Journal of pharmacology and experimental therapeutics.

Circadian rhythm of histamine in the pineal gland.

J. Schwartz, M. Garbarg, C. julien, 1974, Life sciences.

[Development of hystaminergic systems in the newborn rat brain].

J. Schwartz, H. Pollard, S. Bischoff, 1970, Journal of Physiology.

Dopaminergic Behavioral Responses and Classes of Binding Sites Distinguished by Discriminant Benzamide Derivatives

M. Martres, M. Bouthenet, N. Salès, 1986 .

3H-DOMPERIDONE AND 3H-PIMOZIDE : MORE SPECIFIC LIGANDS FOR DOPAMINE RECEPTORS STUDIED IN VITRO AND IN VIVO

M. Baudry, M. Martres, J. Schwartz, 1979 .

Three classes of histamine receptors in brain

J. Schwartz, J. Arrang, M. Garbarg, 1986 .

Metabolism of methylhistamine formed through a new pathway: decarboxylation of L-3-methylhistidine.

J. Schwartz, C. Rose, H. Caillens, 1973, The Journal of pharmacology and experimental therapeutics.

Pitolisant, a wake‐promoting agent devoid of psychostimulant properties: Preclinical comparison with amphetamine, modafinil, and solriamfetol

J. Schwartz, S. Krief, J. Lecomte, 2021, Pharmacology research & perspectives.

Fluorescent non-imidazole histamine H3 receptor ligands with nanomolar affinities.

J. Schwartz, H. Stark, X. Ligneau, 2006, Bioorganic & medicinal chemistry letters.

Development of Novel 1,2,3,4‐Tetrahydroisoquinoline Derivatives and Closely Related Compounds as Potent and Selective Dopamine D3 Receptor Ligands

P. Sokoloff, J. Schwartz, H. Stark, 2004, Chembiochem : a European journal of chemical biology.

Iodoaminopotentidine and related compounds: a new class of ligands with high affinity and selectivity for the histamine H2 receptor.

J. Schwartz, A. Buschauer, W. Schunack, 1992, Journal of medicinal chemistry.

Histamine synthesizing afferents within the amygdaloid complex and bed nucleus of the stria terminalis of the rat

Y. Ben-Ari, J. Schwartz, G. Salle, 1977, Brain Research.

Association between schizophrenia and homozygosity at the dopamine D3 receptor gene.

D. Collier, P. Sokoloff, J. Schwartz, 1992, Journal of medical genetics.

Inhibitory potency of various peptides on enkephalinase activity from mouse striatum.

R. Perdrisot, J. Schwartz, B. Roques, 1979, Biochemical and biophysical research communications.

Sulfation and Desulfation of Cerebral Cholecystokinin

J. Schwartz, K. Zuzel, C. Rose, 1985, Annals of the New York Academy of Sciences.

Biological inactivation of enkephalins and the role of enkephalin-dipeptidyl-carboxypeptidase ("enkephalinase") as neuropeptidase.

J. Schwartz, B. Malfroy, S. de la Baume, 1981, Life sciences.

Azole derivatives as histamine H3 receptor antagonists, part 2: C-C and C-S coupled heterocycles.

J. Schwartz, H. Stark, T. Kottke, 2010, Bioorganic & medicinal chemistry letters.

4-Alkynylphenyl imidazolylpropyl ethers as selective histamine H3-receptor antagonists with high oral central nervous system activity.

J. Schwartz, H. Stark, M. Garbarg, 1998, Journal of medicinal chemistry.

A novel series of (phenoxyalkyl)imidazoles as potent H3-receptor histamine antagonists.

J. Schwartz, B. Bang-Andersen, C. Ganellin, 1996, Journal of medicinal chemistry.

4-(ω-(Alkyloxy)alkyl)-1H-imidazole Derivatives as Histamine H3 Receptor Antagonists/Agonists

J. Schwartz, H. Stark, J. Arrang, 2004 .

Acidic elements in histamine H(3) receptor antagonists.

J. Schwartz, H. Stark, M. Schubert-Zsilavecz, 2010, Bioorganic & Medicinal Chemistry Letters.

[125I]iodoproxyfan, a new antagonist to label and visualize cerebral histamine H3 receptors.

J. Schwartz, H. Stark, J. Díaz, 1994, The Journal of pharmacology and experimental therapeutics.

Analogues and derivatives of ciproxifan, a novel prototype for generating potent histamine H3-receptor antagonists.

J. Schwartz, H. Stark, J. Arrang, 2000, Bioorganic & medicinal chemistry letters.

Histaminergic Transmission in the Brain

J. Schwartz, H. Pollard, M. Garbarg, 2011 .

A detailed mapping of hist amine H1-receptors in guinea-pig central nervous system established by autoradiography with [125I]iodobolpyramine

M. Bouthenet, N. Salès, J. Schwartz, 1988, Neuroscience.

Pharmacological characterization of histamine receptors mediating the stimulation of cyclic AMP accumulation in slices from guinea-pig hippocampus.

J. Schwartz, J. Palacios, G. Barbin, 1978, Molecular Pharmacology.

N-(ω-(4-(2-Methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as Dopamine D2 and D3 Receptor Ligands

P. Sokoloff, J. Schwartz, H. Stark, 2003 .

Highly potent and selective ligands for histamine H3-receptors

J. Schwartz, J. Arrang, J. Lecomte, 1987, Nature.

A functional test identifies dopamine agonists selective for D3 versus D2 receptors.

P. Sokoloff, J. Schwartz, F. Sautel, 1995, Neuroreport.

Search for Histamine H3 Receptor Ligands with Combined Inhibitory Potency at Histamine N‐Methyltransferase: ω‐Piperidinoalkanamine Derivatives

J. Schwartz, H. Stark, J. Arrang, 2004, Archiv der Pharmazie.

(Partial) agonist/antagonist properties of novel diarylalkyl carbamates on histamine H3 receptors.

J. Schwartz, H. Stark, C. Ganellin, 2000, Bioorganic & medicinal chemistry.

Opioid Peptides and their Relevance for CNS Mechanisms; Role of “Enkephalinase” (Enkephalin-Dipeptidylcarboxypeptidase) as Synaptic Neuropeptidase

Y. Agid, J. Schwartz, B. Roques, 1982 .

Sensitive Radioimmunoassays for Histamine and tele‐Methylhistamine in the Brain

J. Schwartz, H. Pollard, M. Garbarg, 1989, Journal of neurochemistry.

Synthesis and evaluation of a 2-benzothiazolylphenylmethyl ether class of histamine H4 receptor antagonists.

J. Schwartz, N. Levoin, T. Calmels, 2016, Bioorganic & medicinal chemistry letters.

Fasidotril: The First Dual Inhibitor of Neprilysin and ACE

J. Schwartz, J. Lecomte, C. Marie, 2006 .

Pharmacological specificity of brain histamine H2-receptors differs in intact cells and cell-free preparations

J. Schwartz, M. Garbarg, M. Tuong, 1980, Nature.

Histamine as a Neurotransmitter in Mammalian Brain: Neurochemical Evidence

J. Schwartz, H. Pollard, Thanh Tarn Quach, 1980, Journal of neurochemistry.

Minireview: histamine receptors in brain.

J. Schwartz, 1979, Life sciences.

Detailed mapping of the histamine H2 receptor and its gene transcripts in guinea-pig brain

M. Bouthenet, J. Schwartz, E. Souil, 1997, Neuroscience.

Pharmacological Characterization and Autoradiographic Localization of Histamine H2 Receptors in Human Brain Identified with [125I]Iodoaminopotentidine

J. Schwartz, J. Palacios, H. Pollard, 1992, Journal of neurochemistry.

Effects of histamine H3-receptor ligands on various biochemical indices of histaminergic neuron activity in rat brain.

J. Schwartz, M. Garbarg, C. Gros, 1989, European journal of pharmacology.

Histamine neuronal pathways and their functions

J. Schwartz, H. Pollard, 1987, Trends in Neurosciences.

Properties and roles of the three subclasses of histamine receptors in brain.

J. Schwartz, M. Korner, J. Arrang, 1986, The Journal of experimental biology.

Actions of betahistine at histamine receptors in the brain.

J. Schwartz, E. Yeramian, J. Arrang, 1985, European journal of pharmacology.

Interaction between mianserin, an antidepressant drug, and central H1- and H2-histamine-receptors: In vitro and in vivo studies and radioreceptor assay

J. Schwartz, J. Arrang, M. Garbarg, 1983, Neuropharmacology.

Histamine Receptors and Actions in Mammalian Brain

J. Schwartz, M. Garbarg, T. T. Quach, 1983 .

Chapter Nine – Histamine Receptors in the Brain and Their Possible Functions

J. Schwartz, A. Duchemin, H. Pollard, 1982 .

Labeling of histamine H1-receptors in the brain of the living mouse

J. Schwartz, A. Duchemin, T. T. Quach, 1980, Neuroscience Letters.

Involvement of histaminergic neurons in arousal mechanisms demonstrated with H3-receptor ligands in the cat

J. Schwartz, M. Jouvet, G. Vanni-Mercier, 1990, Brain Research.

Purification, cDNA cloning, functional expression, and characterization of a 26-kDa endogenous mammalian carboxypeptidase inhibitor.

M. Martres, J. Schwartz, E. Normant, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Treatment of refractory diarrhoea in AIDS with acetorphan and octreotide: a randomized crossover study.

J. Schwartz, W. Rozenbaum, S. Chaussade, 1996, European journal of gastroenterology & hepatology.

STUDIES ON S‐ADENOSYLHOMOCYSTEINE INHIBITION OF HISTAMINE TRANSMETHYLATION IN BRAIN

M. Baudry, J. Schwartz, F. Chast, 1973, Journal of neurochemistry.

Ontogeny of dopaminergic D-2 receptors in the rat nervous system: Characterization and detailed autoradiographic mapping with [125I]iodosulpride

M. Martres, M. Bouthenet, N. Salès, 1989, Neuroscience.

[125I]iodoproxyfan and related compounds: a reversible radioligand and novel classes of antagonists with high affinity and selectivity for the histamine H3 receptor.

J. Schwartz, H. Stark, M. Garbarg, 1996, Journal of medicinal chemistry.

The dopamine D3 receptor mediates locomotor hyperactivity induced by NMDA receptor blockade

P. Sokoloff, J. Schwartz, L. Leriche, 2003, Neuropharmacology.

The Dopamine D3 Receptor and Its Implication in Neuropsychiatry Disorders and Their Treatments

P. Sokoloff, J. Schwartz, 2002 .

Selective increase of dopamine D3 receptor gene expression as a common effect of chronic antidepressant treatments

P. Sokoloff, J. Schwartz, J. Díaz, 2000, Molecular Psychiatry.

New psychiatric drug combination and use of an antagonist or inverse agonist of the histamine H3 receptor to prepare a medicine to prevent undesirable effects of psychotropics.

J. Schwartz, J. Lecomte, 2003 .

Piperidino-hydrocarbon compounds as novel non-imidazole histamine H(3)-receptor antagonists.

J. Schwartz, H. Stark, C. Ganellin, 2002, Bioorganic & medicinal chemistry.

5. Histamine receptor expression¶Impact of lipophilicity on the pharmacological properties of histamine H3-receptor antagonists of the cycloalkyl carbamate class

J. Schwartz, H. Stark, K. Kieć‐Kononowicz, 2002, Inflammation Research.

Benzophenone Derivatives and Related Compounds as Potent Histamine H3‐Receptor Antagonists and Potential PET/SPECT Ligands

J. Schwartz, H. Stark, J. Arrang, 2001, Archiv der Pharmazie.

Neurochemical and behavioral effects of ciproxifan, a potent histamine H3-receptor antagonist.

J. Schwartz, M. Jouvet, H. Stark, 1998, The Journal of pharmacology and experimental therapeutics.

Different antagonist binding properties of human and rat histamine H3 receptors.

J. Schwartz, H. Stark, W. Sippl, 2001, Bioorganic & medicinal chemistry letters.

Diphenylmethyl ethers: synthesis and histamine H3-receptor antagonist in vitro and in vivo activity

J. Schwartz, H. Stark, J. Arrang, 1996 .

Novel Histamine H3‐Receptor Antagonists with Benzyl Ether Structure or Related Moieties: Synthesis and Structure‐Activity Relationships

J. Schwartz, H. Stark, J. Arrang, 1996, Archiv der Pharmazie.

Stimulation of cerebral histamine H2 receptors by clonidine

J. Schwartz, A. Virion, Y. Audigier, 1976, Nature.

3H-apomorphine labels both dopamine postsynaptic receptors and autoreceptors

M. Martres, P. Sokoloff, J. Schwartz, 1980, Nature.

Immunolocalization of tripeptidyl peptidase II, a cholecystokinin-inactivating enzyme, in rat brain

J. Schwartz, P. Rostaing, A. Triller, 1999, Neuroscience.

Characterization of a serine peptidase responsible for the inactivation of endogenous cholecystokinin in human brain

J. Schwartz, B. Devaux, C. Rose, 1995, Neuropeptides.

Role of a serine endopeptidase in the hydrolysis of exogenous cholecystokinin by brain slices

J. Schwartz, C. Rose, A. Camus, 1989, Neuroscience.

Protection by serine peptidase inhibitors of endogenous cholecystokinin released from brain slices

J. Schwartz, C. Rose, A. Camus, 1989, Neuroscience.

Enkephalin receptors on dopaminergic neurones in rat striatum

J. Schwartz, C. Llorens-Cortes, H. Pollard, 1977, Nature.

Modulation in the sensitivity of noradrenergic receptors in the CNS studied by the responsiveness of the cyclic AMP system

M. Baudry, M. Martres, J. Schwartz, 1976, Brain Research.

Novel and highly potent histamine H3 receptor ligands. Part 1: withdrawing of hERG activity.

Marc Capet, Nicolas Levoin, J. Schwartz, 2011, Bioorganic & medicinal chemistry letters.

Novel histamine H(3)-receptor antagonists with carbonyl-substituted 4-(3-(phenoxy)propyl)-1H-imidazole structures like ciproxifan and related compounds.

J. Schwartz, H. Stark, J. Arrang, 2000, Journal of medicinal chemistry.

Novel partial agonists for the histamine H(3) receptor with high in vitro and in vivo activity.

J. Schwartz, H. Stark, C. Ganellin, 1999, Journal of medicinal chemistry.

New histamine H(3)-receptor ligands of the proxifan series: imoproxifan and other selective antagonists with high oral in vivo potency.

J. Schwartz, H. Stark, J. Arrang, 2000, Journal of medicinal chemistry.

Benzophenone Derivatives and Related Compounds as Potent Histamine H3‐Receptor Antagonists and Potential PET/SPECT Ligands.

J. Schwartz, H. Stark, J. Arrang, 2001 .

Development of FUB 181, a Selective Histamine H3‐Receptor Antagonist of High Oral in Vivo Potency with 4‐(?gv‐(Arylalkyloxy)alkyl)‐1H‐imidazole Structure

J. Schwartz, H. Stark, J. Arrang, 1998, Archiv der Pharmazie.

Design of potent non-thiourea H3-receptor histamine antagonists.

J. Schwartz, J. Arrang, M. Garbarg, 1995, Journal of medicinal chemistry.

Synthesis, absolute configuration, stereoselectivity, and receptor selectivity of (alpha R, beta S)-alpha,beta-dimethylhistamine, a novel high potent histamine H3 receptor agonist.

J. Schwartz, J. Arrang, M. Garbarg, 1992, Journal of medicinal chemistry.

RELATIONSHIP BETWEEN LIPOPHILICITY AND BRAIN UPTAKE OF AZOMETHINE PRODRUGSOF A HISTAMINE H3-RECEPTOR AGONIST

J. Schwartz, H. Stark, M. Garbarg, 1996 .

New Potent Azomethine Prodrugs of the Histamine H3‐Receptor Agonist (R)‐α‐Methylhistamine Containing a Heteroarylphenyl Partial Structure

J. Schwartz, H. Stark, M. Garbarg, 1996, Archiv der Pharmazie.

Synthesis and histamine H3-receptor agonist activity of mono- and dialkyl-substituted histamine derivatives†

J. Schwartz, H. Stark, J. Arrang, 1995 .

Imetit and N-methyl derivatives. The transition from potent agonist to antagonist at histamine H3 receptors.1

J. Schwartz, J. Arrang, B. Bang-Andersen, 1992 .

Stereoselectivity of the histamine H3-presynaptic autoreceptor.

J. Schwartz, J. Arrang, W. Schunack, 1985, European journal of pharmacology.

A detailed mapping of the histamine H3 receptor and its gene transcripts in rat brain

J. Schwartz, J. Arrang, X. Ligneau, 2002, Neuroscience.

Radiosynthesis and biodistribution of two potential antagonists of cerebral histamine H3 receptors for PET studies: [18F]FUB 272 and [11C]UCL 1829

C. Crouzel, J. Schwartz, H. Stark, 1998 .

A detailed autoradiographic mapping of histamine H3 receptors in rat brain areas

J. Schwartz, J. Arrang, H. Pollard, 1993, Neuroscience.

The Histamine receptor

H. Haas, J. Schwartz, 1991 .

Diphenylmethyl Ethers: Synthesis and Histamine H3-Receptor Antagonist in vitro and in vivo Activity.

J. Schwartz, H. Stark, J. Arrang, 1996 .

P84 novel potent histamine H3-receptor antagonists

J. Schwartz, H. Stark, M. Garbarg, 1994 .

Responses of anterior pituitary hormones and hypothalamic histamine to blockade of histamine synthesis and to selective activation or inactivation of presynaptic histamine H3 receptors in stressed rats.

J. Schwartz, A. Kjaer, U. Knigge, 1993, Neuroendocrinology.

Novel Histamine H3-Receptor Antagonists with Benzyl Ether Structure or Related Moieties: Synthesis and Structure-Activity Relationships.

J. Schwartz, H. Stark, J. Arrang, 1997 .

Relationship between occupation of cerebral H1-receptors and sedative properties of antihistamines. Assessment in the case of terfenadine.

J. Schwartz, T. T. Quach, C. Llorens, 1982, Arzneimittel-Forschung.

Formation and inactivation of endogenous cannabinoid anandamide in central neurons

J. Schwartz, V. Marzo, A. Fontana, 1994, Nature.

Neurochemical Investigations into the Human Area Postrema

Y. Agid, M. Martres, M. Bouthenet, 1986 .

The dopamine receptor family: molecular biology and pharmacology

M. Martres, P. Sokoloff, J. Schwartz, 1992 .

Chromosomal localization of the human D3 dopamine receptor gene

M. Martres, P. Sokoloff, J. Schwartz, 1991, Human Genetics.

Homozygosity at the dopamine D3 receptor gene is associated with opiate dependence

P. Sokoloff, J. Schwartz, P. Gorwood, 1998, Molecular Psychiatry.

Metabolism of enkephalins and the inactivating neuropeptidase concept

J. Schwartz, 1983, Trends in Neurosciences.

Cloning of OL1, a putative olfactory receptor and its expression in the developing rat heart.

J. Schwartz, G. Drutel, J. Arrang, 1995, Receptors & channels.

Novel Dopamine Receptor Subtypes as Targets for Antipsychotic Drugs

M. Martres, P. Sokoloff, J. Schwartz, 1995, Annals of the New York Academy of Sciences.

A serine to glycine substitution at position 9 in the extracellular N-terminal part of the dopamine D3 receptor protein: No role in the genetic predisposition to bipolar affective disorder

S. Cichon, M. Rietschel, M. Nöthen, 1993, Psychiatry Research.

An inverse agonist of the histamine H3 receptor improves wakefulness in narcolepsy: Studies in orexin−/− mice and patients

J. Schwartz, H. Bastuji, I. Arnulf, 2008, Neurobiology of Disease.

Modulation of receptor mechanisms in the CNS: Hyper-and hyposensitivity to catecholamines

M. Baudry, M. Martres, J. Schwartz, 1978, Neuropharmacology.

Long-term changes in the sensitivity of pre- and postsynaptic dopamine receptors in mouse striatum evidenced by behavioural and biochemical studies

M. Baudry, M. Martres, J. Schwartz, 1977, Brain Research.

The effect of atropine on histidine decarboxylase of the stomach of the rat

J. Schwartz, Y. Cohen, G. Valette, 1969 .

Shorter variants of the D3 dopamine receptor produced through various patterns of alternative splicing.

M. Martres, P. Sokoloff, J. Schwartz, 1991, Biochemical and biophysical research communications.

Alternative splicing directs the expression of two D2 dopamine receptor isoforms

M. Martres, P. Sokoloff, J. Schwartz, 1989, Nature.

Selective Expression of Dopamine D3 Receptor mRNA in Proliferative Zones during Embryonic Development of the Rat Brain

P. Sokoloff, J. Schwartz, N. Griffon, 1997, The Journal of Neuroscience.

Localization of opiate receptors in substantia nigra evidence by lesion studies

J. Schwartz, C. Llorens-Cortes, H. Pollard, 1979, Neuroscience Letters.

Hypersensitivity to noradrenaline in cortex after chronic morphine: relevance to tolerance and dependence

M. Baudry, M. Martres, J. Schwartz, 1978, Nature.

Linkage analysis of schizophrenia with five dopamine receptor genes in nine pedigrees.

H. Coon, M. Hoff, P. Sokoloff, 1993, American journal of human genetics.

Climbing behavior induced by apomorphine in mice: a simple test for the study of dopamine receptors in striatum

J. Schwartz, J. Costentin, P. Protais, 1976, Psychopharmacology.

3H-Domperidone: A selective ligand for dopamine receptors

M. Baudry, M. Martres, J. Schwartz, 1979, Naunyn-Schmiedeberg's Archives of Pharmacology.

Three classes of dopamine receptor (D-2, D-3, D-4) identified by binding studies with 3H-apomorphine and 3H-domperidone

M. Martres, P. Sokoloff, J. Schwartz, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation.

J. Schwartz, R. Leurs, J. Arrang, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Specific desensitization of histamine H1 receptor-mediated [3H]glycogen hydrolysis in brain slices.

J. Schwartz, A. Duchemin, T. T. Quach, 1981, Molecular pharmacology.

Conformation and biological activities of hexapeptides related to enkephalins: respective roles of the ammonium and hydroxyl groups of tyrosine.

J. Schwartz, B. Roques, J. Lecomte, 1979, Life sciences.

[125I]Iodobolpyramine, a highly sensitive probe for histamine H1-receptors in guinea-pig brain.

M. Bouthenet, N. Salès, J. Schwartz, 1986, European journal of pharmacology.

Iodobolpyramine and other iodinated derivatives as ligands for detecting histamine H1 receptors

J. Schwartz, M. Korner, C. Ganellin, 1987 .

Photoaffinity Labeling and Electrophoretic Identification of the H1‐Receptor: Comparison of Several Brain Regions and Animal Species

J. Schwartz, M. Ruat, 1989, Journal of neurochemistry.

Phencyclidine blocks histamine H3-receptors in rat brain.

J. Schwartz, J. Arrang, N. Defontaine, 1988, European journal of pharmacology.

The enkephalinase inhibitor, acetorphan, in acute diarrhoea. A double-blind, controlled clinical trial versus loperamide.

J. Schwartz, J. Lecomte, J. Rogé, 1993, Scandinavian journal of gastroenterology.

Disappearance of energy-transfer as a tool for fluorimetric study of the degradation of enkephalins by aminopeptidase activity from mouse brain.

J. Schwartz, B. Roques, J. Barbet, 1979, Biochemical and biophysical research communications.

Metabolism of enkephalins and its inhibition

J. Schwartz, B. Giros, B. Malfroy, 1984 .

Characterization of histamine H1-receptor binding peptides in guinea pig brain using [125I]iodoazidophenpyramine, an irreversible specific photoaffinity probe.

J. Schwartz, M. Korner, C. Ganellin, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Histaminergic mechanisms in brain.

J. Schwartz, 1977, Annual review of pharmacology and toxicology.

Neuropharmacology of Histamine in Brain

J. Schwartz, R. Faucard, 2007 .

Ciproxifan, a histamine H3‐receptor antagonist/inverse agonist, modulates the effects of methamphetamine on neuropeptide mRNA expression in rat striatum

J. Schwartz, J. Arrang, A. Héron, 2003, The European journal of neuroscience.

14 HISTAMINE

J. Schwartz, J. Arrang, 2001 .

Dual localization of histamine in an ascending neuronal pathway and in non-neuronal cells evidenced by lesions in the lateral hypothalamic area

J. Schwartz, H. Pollard, G. Barbin, 1976, Brain Research.

Enkephalin metabolism in brain and its inhibition

J. Schwartz, J. Costentin, H. Marcais-Collado, 1982, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Normal cerebrospinal fluid histamine and tele-methylhistamine levels in hypersomnia conditions.

J. Schwartz, I. Jaussent, Y. Dauvilliers, 2012, Sleep.

Autoreceptors and Heteroreceptors Evidenced by Histamine H3 Receptor Ligands

J. Schwartz, H. Stark, J. Arrang, 1991 .

New aspects of the role of histamine in cardiovascular function: identification, characterization, and potential pathophysiological importance of H3 receptors.

J. Schwartz, J. Hey, M. Garbarg, 1995, Canadian journal of physiology and pharmacology.

Possible implications of the dopamine D3 receptor in schizophrenia and in antipsychotic drug actions

P. Sokoloff, J. Schwartz, C. Pilon, 2000, Brain Research Reviews.

Studies on the inhibition of histamine methylation in mice

J. Schwartz, J. M. André, 1973, Agents and Actions.

Histamine in the Brain: Importance of Transmethylation Processes and Their Regulation

M. Baudry, J. Schwartz, H. Pollard, 1974 .

Dopamine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

D. Grandy, D. Sibley, J. Kebabian, 2019, IUPHAR/BPS Guide to Pharmacology CITE.

Functional implications of multiple dopamine receptor subtypes: the D1/D3 receptor coexistence 1 Published on the World Wide Web on 24 November 1997. 1

P. Sokoloff, J. Schwartz, R. Bordet, 1998, Brain Research Reviews.

Coexpression of dopamine D1 and D3 receptors in islands of Calleja and shell of nucleus accumbens of the rat: opposite and synergistic functional interactions

P. Sokoloff, J. Schwartz, E. Souil, 1998, The European journal of neuroscience.

A novel rat serotonin (5-HT6) receptor: molecular cloning, localization and stimulation of cAMP accumulation.

J. Schwartz, R. Leurs, J. Arrang, 1993, Biochemical and biophysical research communications.

Metabolism and functions of histamine in the brain.

M. Baudry, M. Martres, J. Schwartz, 1979, Current developments in psychopharmacology.

Neurochemical evidence for histamine acting as a transmitter in mammalian brain.

J. Schwartz, H. Pollard, G. Barbin, 1976, Advances in biochemical psychopharmacology.

Effects of mesencephalic and hypothalamic lesions on histamine levels in rat brain.

J. Féger, J. Schwartz, M. Garbarg, 1973, Brain research.

Endothelin-converting enzyme-1 is expressed in human cerebral cortex and protects against Alzheimer's disease

J. Schwartz, A. Delacourte, J. David, 2004, Molecular Psychiatry.

Formation and Utilization of the Active Sulfate Donor [35S]3′‐Phosphoadenosine 5′‐Phosphosulfate in Brain Slices: Effects of Depolarizing Agents

J. Schwartz, F. Vargas, A. Lafitte, 1987, Journal of neurochemistry.

Properties and Localization of the Sulfate‐Activating System in Rat Brain

J. Schwartz, F. Vargas, Francois Brion, 1987, Journal of neurochemistry.

The D3 Dopamine Receptor Gene as a Candidate Gene for Genetic Linkage Studies

M. Martres, M. Bouthenet, P. Sokoloff, 1992 .

Histamine as a transmitter in brain.

J. Schwartz, Jean-Charles Schwartz, 1975, Life sciences.

BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization

P. Sokoloff, J. Schwartz, O. Guillin, 2001, Nature.

No evidence of linkage between schizophrenia and D3 dopamine receptor gene locus in Icelandic pedigrees

P. Sokoloff, J. Schwartz, L. Lannfelt, 1993, Psychiatry Research.

P. Sokoloff, J. Schwartz, G. Sedvall, 1996, Biological Psychiatry.

Activation of dopamine D4 receptor inhibits an L-type calcium current in cerebellar granule cells

M. Martres, P. Sokoloff, J. Schwartz, 1995, Neuroscience.

Novel dopamine receptors half a decade later.

P. Sokoloff, J. Schwartz, 1995, Trends in pharmacological sciences.

The Dopamine D3 Receptor in the Pathophysiology and Treatment of Neuropsychiatric Disorders

P. Sokoloff, J. Schwartz, O. Guillin, 2003 .

Autoradiographic localisation of3H-apomorphine binding sites in rat brain

M. Bouthenet, N. Salès, J. Schwartz, 1985, Naunyn-Schmiedeberg's Archives of Pharmacology.

Selection of dopamine antagonists discriminating various behavioral responses and radioligand binding sites

M. Martres, P. Sokoloff, J. Schwartz, 1984, Naunyn-Schmiedeberg's Archives of Pharmacology.

The third dopamine receptor (D3) as a novel target for antipsychotics.

M. Martres, M. Bouthenet, P. Sokoloff, 1992, Biochemical pharmacology.

Exploratory Phase II Trial to Evaluate the Safety and the Antiepileptic Effect of Pitolisant (BF2.649) in Refractory Partial Seizures, Given as Adjunctive Treatment During 3 Months

J. Schwartz, P. Kahane, A. Biraben, 2016, Clinical neuropharmacology.

Efficacy of the histamine 3 receptor (H3R) antagonist pitolisant (formerly known as tiprolisant; BF2.649) in epilepsy: Dose-dependent effects in the human photosensitivity model

J. Schwartz, P. Genton, E. Hirsch, 2013, Epilepsy & Behavior.

Lack of Association between Anorexia Nervosa and D3 Dopamine Receptor Gene

J. Schwartz, P. Gorwood, M. Bouvard, 1998, Biological Psychiatry.

D3 dopamine receptor mRNA is widely expressed in the human brain

P. Sokoloff, J. Schwartz, Y. Hurd, 1998, Brain Research.

Simultaneous presence of histamine-N-methyltransferase and catechol-O-methyltransferase in neuronal and glial cells in culture

M. Baudry, J. Schwartz, M. Garbarg, 1975, Brain Research.

Bioavailability and Cardiovascular Effects of Adrenaline Administered by Anapen Autoinjector in Healthy Volunteers.

J. Schwartz, P. Lehert, J. Lecomte, 2017, The journal of allergy and clinical immunology. In practice.

Parallel synthesis and dopamine D3/D2 receptor screening of novel {4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}carboxamides.

J. Schwartz, H. Stark, A. Link, 2005, Bioorganic & Medicinal Chemistry.

Synthesis and evaluation of amides surrogates of dopamine D3 receptor ligands.

J. Schwartz, P. Uriac, N. Levoin, 2010, Bioorganic & medicinal chemistry letters.

Role of delta opioid receptors in the effects of inhibitors of enkephalin-degrading peptidases on the horizontal and vertical components of locomotion in mice

J. Schwartz, J. Costentin, A. Michael-Titus, 1990, Neuropeptides.

Comparison of acetorphan with clonidine for opiate withdrawal symptoms.

J. Schwartz, H. Lôo, M. Bourdel, 1991, The American journal of psychiatry.

A rat G protein‐coupled receptor selectively expressed in myelin‐forming cells

P. Sokoloff, J. Schwartz, B. Zalc, 1998, The European journal of neuroscience.

Ontogeny, regional and cellular distribution of the novel metalloprotease neprilysin 2 in the rat: a comparison with neprilysin and endothelin-converting enzyme-1

J. Schwartz, P. Facchinetti, T. Ouimet, 2003, Neuroscience.

Phenotypical characterization of neurons expressing the dopamine D3 receptor in the rat brain

M. Martres, P. Sokoloff, J. Schwartz, 1995, Neuroscience.

Meta-analysis of DRD3 gene and schizophrenia: ethnic heterogeneity and significant association in Caucasians.

P. Sokoloff, J. Schwartz, P. Gorwood, 1998, American journal of medical genetics.

Multiple Dopamine Receptors: Implications for Schizophrenia

M. Martres, P. Sokoloff, J. Schwartz, 1995 .

Purification of membrane-bound aminopeptidase from rat brain: Identification of aminopeptidase M

J. Schwartz, B. Giros, C. Gros, 1985, Neuropeptides.

Characterization of a tyrosine sulfotransferase in rat brain using cholecystokinin derivatives as acceptors.

J. Schwartz, F. Vargas, M. Tuong, 1985, Biochemistry.

ARNT2, a transcription factor for brain neuron survival?

J. Schwartz, G. Drutel, J. Arrang, 1999, The European journal of neuroscience.

Functional coupling of the human dopamine D3 receptor in a transfected NG 108-15 neuroblastoma-glioma hybrid cell line.

M. Martres, P. Sokoloff, J. Schwartz, 1994, European journal of pharmacology.

Characterization of aminopeptidases responsible for inactivating endogenous (Met5)enkephalin in brain slices using peptidase inhibitors and anti-aminopeptidase M antibodies.

J. Schwartz, B. Giros, B. Solhonne, 1986, Molecular pharmacology.

H3‐Receptors Control Histamine Release in Human Brain

J. Schwartz, J. Chodkiewicz, J. Arrang, 1988, Journal of neurochemistry.

Histamine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

H. Haas, J. Schwartz, R. Thurmond, 2019, IUPHAR/BPS Guide to Pharmacology CITE.

Multiple dopamine receptors: the D3 receptor and actions of substances of abuse.

M. Martres, P. Sokoloff, J. Schwartz, 1994, EXS.

Pharmacology of human dopamine D3 receptor expressed in a mammalian cell line: comparison with D2 receptor.

M. Martres, P. Sokoloff, J. Schwartz, 1992, European journal of pharmacology.

A serine peptidase responsible for the inactivation of endogenous cholecystokinin in brain.

J. Schwartz, C. Rose, A. Camus, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Photoaffinity labeling of D-2 dopamine binding subunits from rat striatum, anterior pituitary and olfactory bulb with a new probe, [3H]azidosulpride.

P. Sokoloff, J. Schwartz, C. Wermuth, 1985, Biochemical and biophysical research communications.

errata Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist

B. Everitt, P. Sokoloff, J. Schwartz, 1999, Nature.

The histamine H3 receptor: from discovery to clinical trials with pitolisant

J. Schwartz, Jean-Charles Schwartz, 2011, British journal of pharmacology.

Third Histamine Receptor: From Discovery to Clinics, Long-Lasting Love Story at INSERM and Bioprojet

J. Schwartz, 2008 .

Ciproxifan, a Histamine H3-Receptor Antagonist/Inverse Agonist, Potentiates Neurochemical and Behavioral Effects of Haloperidol in the Rat

J. Schwartz, J. Arrang, A. Héron, 2002, The Journal of Neuroscience.

Expression analysis of the histamine H3 receptor in developing rat tissues

J. Schwartz, J. Arrang, A. Rouleau, 2001, Mechanisms of Development.

The rat H3 receptor: gene organization and multiple isoforms.

J. Schwartz, J. Arrang, F. Gbahou, 2001, Biochemical and biophysical research communications.

Nafadotride, a potent preferential dopamine D3 receptor antagonist, activates locomotion in rodents.

P. Sokoloff, J. Schwartz, F. Sautel, 1995, The Journal of pharmacology and experimental therapeutics.

No association between schizophrenia and homozygosity at the D3 dopamine receptor gene.

P. Sokoloff, J. Schwartz, Liu Yang, 1993, American journal of medical genetics.

Obstructive Sleep Apnea patients adhering to Continuous positive Airway Pressure: A randomized trial.

J. Pépin, J. Schwartz, M. Partinen, 2020, Chest.

Pitolisant for Daytime Sleepiness in Obstructive Sleep Apnea Patients Refusing CPAP: A Randomized Trial.

J. Pépin, J. Schwartz, M. Partinen, 2020, American journal of respiratory and critical care medicine.

Functional potencies of new antiparkinsonian drugs at recombinant human dopamine D1, D2 and D3 receptors.

P. Sokoloff, J. Schwartz, S. Perachon, 1999, European journal of pharmacology.

Hemodynamic effects of acute and chronic treatment with aladotril, a mixed inhibitor of neutral endopeptidase and angiotensin I-converting enzyme, in conscious rats with myocardial infarction.

J. Schwartz, J. Lecomte, C. Marie, 1995, The Journal of pharmacology and experimental therapeutics.

Effects of alatriopril, a mixed inhibitor of atriopeptidase and angiotensin I-converting enzyme, on cardiac hypertrophy and hormonal responses in rats with myocardial infarction. Comparison with captopril.

J. Schwartz, J. Lecomte, C. Marie, 1994, The Journal of pharmacology and experimental therapeutics.

A detailed mapping of dopamine D-2 receptors in rat central nervous system by autoradiography with [125I]iodosulpride

M. Martres, M. Bouthenet, N. Salès, 1987, Neuroscience.

Histamine formation in rat stomach: study of regulation mechanisms.

J. Schwartz, Y. Cohen, A. Ronnberg, 1969, European journal of pharmacology.

Pitolisant versus placebo or modafinil in patients with narcolepsy: a double-blind, randomised trial

J. Schwartz, I. Arnulf, Y. Dauvilliers, 2013, The Lancet Neurology.

Involvement of the direct striatonigral pathway in levodopa‐induced sensitization in 6‐hydroxydopamine‐lesioned rats

P. Sokoloff, J. Schwartz, R. Bordet, 2000, The European journal of neuroscience.

J. Schwartz, W. Rozenbaum, G. Pialoux, 1995 .

Evaluation of enkephalinase inhibition in the living mouse, using [3H]acetorphan as a probe.

J. Schwartz, F. Brion, S. de la Baume, 1988, The Journal of pharmacology and experimental therapeutics.

Subclassification of histamine receports, H3-receptor subtypes? Localization of H3 receptors in the brain

J. Schwartz, J. Arrang, S. Morisset, 1998 .

In vivo occupation of cerebral histamine H1-receptors evaluated with 3H-mepyramine may predict sedative properties of psychotropic drugs.

J. Schwartz, A. Duchemin, T. T. Quach, 1979, European journal of pharmacology.

Disruption of nicotine conditioning by dopamine D3 receptor ligands

P. Sokoloff, J. Schwartz, B. Foll, 2003, Molecular Psychiatry.

Glycogenolysis induced by serotonin in brain: identification of a new class of receptor

J. Schwartz, A. Duchemin, T. T. Quach, 1982, Nature.

Optically active benzamides as predictive tools for mapping the dopamine D2 receptor.

D Rognan, M. Martres, P. Sokoloff, 1990, European journal of pharmacology.

Role of the dopamine D3 receptor in reactivity to cocaine‐associated cues in mice

P. Sokoloff, J. Schwartz, B. Le Foll, 2002, The European journal of neuroscience.

Tolerance to hypokinesia elicited by dopamine agonists in mice: hyposensitization of autoreceptors?

J. Schwartz, J. Costentin, P. Protais, 1977, Life sciences.

A gradual score to evaluate the climbing behaviour elicited by apomorphine in mice

J. Schwartz, J. Costentin, P. Protais, 1978, Psychopharmacology.

Adaptive changes of neurotransmitter receptor mechanisms in the central nervous system.

J. Schwartz, H. Pollard, T. Quach, 1983, Progress in brain research.

Interaction of mianserin, amitriptyline and haloperidol with guinea pig cerebral histamine H2 receptors studied with [125I]iodoaminopotentidine.

J. Schwartz, M. Ruat, E. Traiffort, 1991, European Journal of Pharmacology.

Apparent identity of cerebral tyrosylsulfotransferase activities using either a cholecystokinin derivative or an acidic amino acid polymer as substrate

J. Schwartz, F. Vargas, 1987, FEBS letters.

Development of chiral N-alkylcarbamates as new leads for potent and selective H3-receptor antagonists: synthesis, capillary electrophoresis, and in vitro and oral in vivo activity.

J. Schwartz, H. Stark, K. Kieć‐Kononowicz, 1999, Journal of medicinal chemistry.

The dopamine D3 receptor and drug addiction

P. Sokoloff, J. Schwartz, R. Bordet, 2001, Neurotoxicity Research.

Ontogenesis of enkephalinergic systems in rat brain: post-natal changes in enkephalin levels, receptors and degrading enzyme activities.

J. Schwartz, G. Patey, C. Gros, 1980, Life sciences.

HISTAMINE AS A TRANSMITTER IN MAMMALIAN BRAIN

J. Schwartz, 1976 .

The histamine H3-receptor: pharmacology, roles and clinical implications studied with agonists.

J. Schwartz, H. Stark, J. Arrang, 1991, Agents and actions. Supplements.

Reversible and irreversible labeling and autoradiographic localization of the cerebral histamine H2 receptor using [125I]iodinated probes.

M. Bouthenet, J. Schwartz, A. Buschauer, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Efficacy of pitolisant in patients with high burden of narcolepsy symptoms: pooled analysis of short-term, placebo-controlled studies.

J. Schwartz, L. Krahn, M. Thorpy, 2021, Sleep medicine.

Pharmacokinetics of pitolisant in children and adolescents with narcolepsy.

J. Schwartz, G. Plazzi, P. Franco, 2019, Sleep medicine.

Enkephalin biosynthesis and release in mouse striatum are inhibited by GABA receptor stimulation: compared changes in preproenkephalin mRNA and Tyr-Gly-Gly levels.

J. Schwartz, B. Giros, C. Llorens-Cortes, 1990, Brain research. Molecular brain research.

Pharmacological studies of histamine as a central neurotransmitter

M. Baudry, M. Martres, J. Schwartz, 1976 .

In vivo binding of 3H-pimozide in mouse striatum: effects of dopamine agonists and antagonists.

M. Baudry, M. Martres, J. Schwartz, 1977, Life sciences.

Potent inhibition of cerebral aminopeptidases by carbaphethiol, a parenterally active compound

J. Schwartz, B. Giros, J. Costentin, 1988, Neuropeptides.

An alternative route for biosynthesis of methylhistamine: In vitro and in vivo formation through decarboxylation ofl-3-methylhistidine

J. Schwartz, C. Rose, H. Caillens, 1972, Experientia.

N-ethylmaleimide-induced changes in agonist affinity for histamine H1-receptors in the guinea pig brain.

J. Schwartz, E. Yeramian, M. Garbarg, 1985, Molecular pharmacology.

Carboxypeptidase A Isoforms Produced by Distinct Genes or Alternative Splicing in Brain and Other Extrapancreatic Tissues (*)

J. Schwartz, E. Normant, C. Gros, 1995, The Journal of Biological Chemistry.

Identification, characterization, and localization of the dopamine D3 receptor in rat brain using 7-[3H]hydroxy-N,N-di-n-propyl-2-aminotetralin.

M. Martres, P. Sokoloff, J. Schwartz, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Occupancy of dopamine D2 and D3 receptors by a novel D3 partial agonist BP1.4979: a [11C]-(+)-PHNO PET study in humans

Alan A. Wilson, S. Houle, P. Di Ciano, 2018, Neuropsychopharmacology.

The D3 receptor and its relevance in psychiatry

P. Sokoloff, J. Schwartz, C. Wermuth, 1995, International Clinical Psychopharmacology.

Nonclinical cardiovascular safety of pitolisant: comparing International Conference on Harmonization S7B and Comprehensive in vitro Pro‐arrhythmia Assay initiative studies

Gary R. Mirams, J. Schwartz, P. Maison-Blanche, 2017, British journal of pharmacology.

Role of endogenous enkephalins in locomotion and nociception studied with peptidase inhibitors in two inbred strains of mice (C57BL/6J AND DBA/2J)

J. Schwartz, J. Costentin, A. Michael-Titus, 1989, Neuropharmacology.

Enantiomers of thiorphan and acetorphan: correlation between enkephalinase inhibition, protection of endogenous enkephalins and behavioral effects.

J. Schwartz, B. Giros, J. Costentin, 1987, The Journal of pharmacology and experimental therapeutics.

N-(omega-(4-(2-methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as dopamine D2 and D3 receptor ligands.

P. Sokoloff, J. Schwartz, H. Stark, 2003, Journal of Medicinal Chemistry.

Changes in levels of the tripeptide Tyr-Gly-Gly as an index of enkephalin release in the spinal cord: Effects of noxious stimuli and parenterally-active peptidase inhibitors

J. Schwartz, C. Llorens-Cortes, A. M. Clot, 1989, Peptides.

A paradoxical regulation of the dopamine D3 receptor expression suggests the involvement of an anterograde factor from dopamine neurons.

M. Martres, P. Sokoloff, J. Schwartz, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Dopamine activation of the arachidonic acid cascade as a basis for D1D2 receptor synergism

M. Martres, J. Schwartz, B. Giros, 1991, Nature.

Synthesis, X‐Ray Crystallography, and Pharmacokinetics of Novel Azomethine Prodrugs of (R)‐α‐Methylhistamine: Highly Potent and Selective Histamine H3 Receptor Agonists.

J. Schwartz, H. Stark, M. Garbarg, 1996 .

Histaminergic Systems in Brain

J. Schwartz, J. Palacios, H. Pollard, 1979 .

Localisation and pharmacological characterisation of D-2 dopamine receptors in rat cerebral neocortex and cerebellum using [125I]iodosulpride.

M. Martres, M. Bouthenet, N. Salès, 1985, European journal of pharmacology.

Peptidases involved in the inactivation of exogenous and endogenous enkephalins.

J. Schwartz, J. Costentin, H. Marcais-Collado, 1983, Journal of neural transmission. Supplementum.

Effects of histamine H3 receptor agonist and antagonist on histamine co-transmitter expression in rat brain

S. Trottier, J. Schwartz, S. Morisset, 2002, Journal of Neural Transmission.

Subsensitivity of noradrenaline-stimulated cyclic AMP accumulation in brain slices of d-amphetamine-treated mice

M. Baudry, M. Martres, J. Schwartz, 1975, Nature.

Dopamine D3 Receptors Expressed by All Mesencephalic Dopamine Neurons

P. Sokoloff, J. Schwartz, A. Triller, 2000, The Journal of Neuroscience.

Dopamine receptors in GtoPdb v.2023.1

D. Grandy, D. Sibley, J. Kebabian, 2023, IUPHAR/BPS Guide to Pharmacology CITE.

Localization and function of the D3 dopamine receptor.

M. Martres, M. Bouthenet, P. Sokoloff, 1992, Arzneimittel-Forschung.

The use of [3H](-)-DO 710 as selective dopaminergic ligand for binding and autoradiographic studies.

M. Martres, M. Bouthenet, N. Salès, 1985, European journal of pharmacology.

The third dopamine receptor (D3): new perspectives in therapeutics.

M. Martres, M. Bouthenet, P. Sokoloff, 1993, Psychopharmacology series.

Stimulation of deoxy[3H]glucose uptake into slices from cerebral cortex elicited by excitatory amino acids

J. Schwartz, F. Brion, M. Tuong, 1984, Neuroscience.

L-Histidine Decarboxylase

J. Schwartz, H. Pollard, 1986 .

Rapid development of hypersensitivity of striatal dopamine receptors induced by alpha-methylparatyrosine and its prevention by protein synthesis inhibitors.

M. Baudry, M. Martres, J. Schwartz, 1977, Life sciences.

Brain-derived neurotrophic factor and the plasticity of the mesolimbic dopamine pathway.

E. Bézard, P. Sokoloff, J. Schwartz, 2004, International review of neurobiology.

Determination of the binding mode and interacting amino-acids for dibasic H3 receptor antagonists.

J. Schwartz, N. Levoin, T. Calmels, 2013, Bioorganic & medicinal chemistry.

Immunohistochemical and subcellular studies of aminopeptidase M localization in rat brain: microvessels and synaptic membranes.

N. Salès, J. Schwartz, B. Giros, 1986, NIDA research monograph.

Heterogeneity and regulation of central dopamine receptor subtypes studied by cDNA cloning methodology

M. Martres, M. Bouthenet, P. Sokoloff, 1992, Neurochemistry International.

Two D2 dopamine receptor isoforms generated via alternative mRNA splicing: regional distribution and effects of haloperidol treatments

M. Martres, P. Sokoloff, J. Schwartz, 1990 .

Monoclonal antibody against l-histidine decarboxylase for localization of histaminergic cells

J. Schwartz, H. Pollard, I. Pachot, 1985, Neuroscience Letters.

Histamine H3 receptors in the brain: potent and selective ligands.

J. Schwartz, J. Arrang, H. Pollard, 1989, Psychopharmacology series.

Three histamine receptors (H1, H2 and H3) visualized in the brain of human and non-human primates

J. Schwartz, J. Palacios, J. Arrang, 1990, Brain Research.

Histamine receptors in GtoPdb v.2021.3

H. Haas, J. Schwartz, R. Thurmond, 2021, IUPHAR/BPS Guide to Pharmacology CITE.

Highly Potent Fluorescence‐Tagged Nonimidazole Histamine H3 Receptor Ligands

J. Schwartz, H. Stark, X. Ligneau, 2007, ChemMedChem.

ONTOGENESIS OF ENKEPHALINERGIC SYSTEMS IN RAT BRAIN

J. Schwartz, G. Patey, C. Gros, 1980 .

Dopaminergic binding sites in rat striatal slices and the action of guanyl nucleotides

M. Martres, P. Sokoloff, J. Schwartz, 1984, Naunyn-Schmiedeberg's Archives of Pharmacology.

Clinical trials with H3-receptor inverse agonists: What they tell us about the role of histamine in the human brain

J. Schwartz, J. Lecomte, 2016, Neuropharmacology.

Evidence for a specific decarboxylase involved in histamine synthesis in an ascending pathway in rat brain

J. Schwartz, H. Pollard, G. Barbin, 1974, Agents and Actions.

Synthesis, X-ray crystallography, and pharmacokinetics of novel azomethine prodrugs of (R)-alpha-methylhistamine: highly potent and selective histamine H3 receptor agonists.

J. Schwartz, H. Stark, M. Garbarg, 1995, Journal of medicinal chemistry.

High constitutive activity of native H3 receptors regulates histamine neurons in brain

Holger Stark, J. Schwartz, H. Stark, 2000, Nature.

Evidence that histamine H3 receptors are involved in the control of gastric acid secretion in the conscious cat

J. Schwartz, G. Coruzzi, G. Bertaccini, 1991, Naunyn-Schmiedeberg's Archives of Pharmacology.

Gastric Antisecretory Effects of Compound BP 2-94 (A Histamine H3-Receptor Agonist Prodrug)

J. Schwartz, G. Coruzzi, S. Bertini, 1999, Digestive Diseases and Sciences.

Structure-activity relationships of novel azomethine prodrugs of the histamine H3-receptor agonist (R)-alpha-methylhistamine: from alkylaryl to substituted diaryl derivatives.

J. Schwartz, H. Stark, M. Garbarg, 1996, Die Pharmazie.

The Third Histamine Receptor

J. Schwartz, J. Arrang, J. Lecomte, 1989 .

A pharmaceutical composition containing a-methylhistamine

J. Schwartz, J. Arrang, M. Garbarg, 1985 .

Functional relationship between mast cells and C-sensitive nerve fibres evidenced by histamine H3-receptor modulation in rat lung and spleen.

J. Schwartz, M. Garbarg, A. Rouleau, 1994, Clinical science.

Effects of cycloheximide and/or morphine on enkephalin levels in mouse striatum.

J. Schwartz, B. Malfroy, F. Dray, 1978, European Journal of Pharmacology.

Characterization of the high-affinity binding sites of [3H]histamine in rat brain.

J. Schwartz, J. Palacios, G. Barbin, 1980, Molecular pharmacology.

Rapid and dissociated changes in sensitivities of different dopamine receptors in mouse brain

J. Schwartz, J. Costentin, P. Protais, 1975, Nature.

Azines and Diazines as Potential Histamine H3‐Receptor Antagonists

J. Schwartz, H. Stark, K. Kieć‐Kononowicz, 1995, Archiv der Pharmazie.

Loss of striatal histamine H2 receptors in Huntington's: Chorea but not in Parkinson's disease: Comparison with animal models

J. Schwartz, J. Palacios, H. Pollard, 1993, Synapse.

Location of enkephalinase and functional effects of [Leu5]enkephalin and inhibition of enkephalinase in the feline main pancreatic and bile duct sphincters.

J. Schwartz, L. Jivegård, J. Svanvik, 1992, Clinical science.

Reversible and irreversible labeling and autoradiographic localization of the cerebral histamine H_2-receptor

M. Bouthenet, J. Schwartz, A. Buschauer, 1990 .

Characterisation of two probes for the localisation of enkephalinase in rat brain: [3H]thiorphan and a 125I-labeled monoclonal antibody.

M. Bouthenet, J. Schwartz, P. Verroust, 1987, European journal of pharmacology.

Exploring occupancy of the histamine H3 receptor by pitolisant in humans using PET

P. Di Ciano, J. Schwartz, I. Boileau, 2020, British journal of pharmacology.

Dopamine D3 receptor: basic and clinical aspects.

M. Martres, P. Sokoloff, J. Schwartz, 1993, Clinical neuropharmacology.

Chromosomal mapping and organization of the human histamine H3 receptor gene

J. Schwartz, J. Arrang, F. Gbahou, 2001, Neuroreport.

FURTHER CHARACTERISATION AND KINETICS OF APPEARANCE OF HYDROLYSIS PRODUCTS OF MET-ENKEPHALIN

R. Perdrisot, J. Schwartz, B. Roques, 1980 .

Presence of dopamine D-2 receptors in human tumoral cell lines.

M. Martres, P. Sokoloff, J. Schwartz, 1989, Biochemical and biophysical research communications.

Identification , characterization , and localization of the dopamine D 3 receptor in rat brain using 7-[ 3 H ] hydroxy-NN-din-propyl-2-aminotetralin ( guanine nucleotide-binding regulatory protein-coupled receptor / antipsychotics / islands of Calleja / cerebellum / nucleus accumbens )

M. Martres, P. Sokoloff, J. Schwartz, 2022 .

3H-(-)DO 710 discriminates guanine nucleotide sensitive and insensitive dopamine binding sites

M. Martres, P. Sokoloff, J. Schwartz, 1985, Naunyn-Schmiedeberg's Archives of Pharmacology.

3H-Dopamine binding sites differ in rat striatum and pituitary.

M. Martres, P. Sokoloff, J. Schwartz, 1984, Naunyn-Schmiedeberg's archives of pharmacology.

Novel chiral H3-receptor agonists.

J. Schwartz, J. Arrang, M. Garbarg, 1991, Agents and actions. Supplements.

Search for histamine H3 receptor antagonists with combined inhibitory potency at Ntau-methyltransferase: ether derivatives.

J. Schwartz, H. Stark, J. Arrang, 2005, Die Pharmazie.

Molecular cloning and amino acid sequence of rat kidney aminopeptidase M: a member of a super family of zinc-metallohydrolases.

J. Schwartz, B. Giros, B. Malfroy, 1989, Biochemical and biophysical research communications.

Time to Onset of Response to Pitolisant for the Treatment of Excessive Daytime Sleepiness and Cataplexy in Patients With Narcolepsy: An Analysis of Randomized, Placebo-Controlled Trials

J. Schwartz, N. Watson, Y. Dauvilliers, 2021, CNS Drugs.