P. Caron

发表

Chemogenomic approaches to drug discovery.

M. Murcko, P. Caron, M. D. Mullican, 2001, Current opinion in chemical biology.

The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase.

G. Bemis, M. Murcko, P. Caron, 1997, Chemistry & biology.

The Structural Basis for 14-3-3:Phosphopeptide Binding Specificity

M. Yaffe, P. Caron, S. Smerdon, 1997, Cell.

X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

P. Caron, M. Navia, K. Hsiao, 1995, Cell.

Classifying protein kinase structures guides use of ligand‐selectivity profiles to predict inactive conformations: Structure of lck/imatinib complex

P. Caron, M. Jacobs, B. Hare, 2007, Proteins.

Chapter 29. Structure-Based Drug Design

Paul R. Caron, Paul S. Charifson, M. Murcko, 1999 .

Crystal Structure of the Hepatitis C Virus NS3 Protease Domain Complexed with a Synthetic NS4A Cofactor Peptide

M. Murcko, P. Caron, C. Rice, 1996, Cell.

Involvement of helicase II (uvrD gene product) and DNA polymerase I in excision mediated by the uvrABC protein complex.

P. Caron, L. Grossman, S. R. Kushner, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Identification and Characterization of CPP32/Mch2 Homolog 1, a Novel Cysteine Protease Similar to CPP32 (*)

P. Caron, M. Su, J. Lippke, 1996, The Journal of Biological Chemistry.

Peptide sequencing and site-directed mutagenesis identify tyrosine-727 as the active site tyrosine of Saccharomyces cerevisiae DNA topoisomerase I.

J. Wang, P. Caron, M. Bjornsti, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Potential role of proteolysis in the control of UvrABC incision.

P. Caron, L. Grossman, 1988, Nucleic acids research.

A mutational analysis of the active site of human type II inosine 5'-monophosphate dehydrogenase.

P. Caron, M. Sintchak, S. Raybuck, 2002, Biochimica et biophysica acta.

Structure and Mechanism of Inosine Monophosphate Dehydrogenase in Complex with the Immunosuppressant Mycophenolic Acid

Mark A. Murcko, Paul R. Caron, M. Murcko, 1996, Cell.

Assignment of the human gene for peptidase E to the chromosomal region 17q23 → 17qter

P. Caron, B. Harrison, D. Wilson, 1984, Annals of human genetics.

Involvement of a cryptic ATPase activity of UvrB and its proteolysis product, UvrB* in DNA repair.

P. Caron, L. Grossman, 1988, Nucleic acids research.

The C-terminal domain of Saccharomyces cerevisiae DNA topoisomerase II

J. Wang, P. Caron, P. Watt, 1994, Molecular and cellular biology.

Rapid decrease of wild-type hepatitis C virus on telaprevir treatment

Eva Herrmann, Brian Hare, Stefan Zeuzem, 2008, Antiviral therapy.

The role of DNA topoisomerases in recombination and genome stability: A double-edged sword?

P. Caron, R. A. Kim, James C. Wang, 1990, Cell.

Appendix. II: Alignment of primary sequences of DNA topoisomerases.

J. Wang, P. Caron, James C. Wang, 1994, Advances in pharmacology.

Computer analysis of cloned sequences.

P R Caron, P. Caron, 1997, Methods in molecular biology.

Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding.

J P Griffith, M. Murcko, P. Caron, 1998, Structure.

Incision of damaged versus nondamaged DNA by the Escherichia coli UvrABC proteins.

P. Caron, L. Grossman, 1988, Nucleic acids research.

A Multi-Variant, Viral Dynamic Model of Genotype 1 HCV to Assess the in vivo Evolution of Protease-Inhibitor Resistant Variants

Chao Lin, Varun Garg, Bambang S. Adiwijaya, 2010, PLoS Comput. Biol..

Crystal structure of JNK3: a kinase implicated in neuronal apoptosis.

P. Caron, K. Wilson, M. Su, 1998, Structure.

Crystal Structure of p38 Mitogen-activated Protein Kinase*

Paul R. Caron, P. Caron, K. Wilson, 1996, The Journal of Biological Chemistry.

Bovine viral diarrhea virus NS3 serine proteinase: polyprotein cleavage sites, cofactor requirements, and molecular model of an enzyme essential for pestivirus replication

M. Murcko, P. Caron, C. Rice, 1997, Journal of virology.

Molecular Dissection of a Protein SopB Essential for Escherichia coli F Plasmid Partition*

P. Caron, A. S. Lynch, James C. Wang, 1996, The Journal of Biological Chemistry.

Repair of DNA‐containing pyrimidine dimers

P. Caron, L. Grossman, S. Mazur, 1988, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The involvement of an E. coli multiprotein complex in the complete repair of UV-damaged DNA.

P. Caron, L. Grossman, E. Oh, 1986, Basic life sciences.

Human TOP3: a single-copy gene encoding DNA topoisomerase III.

J. Wang, P. Caron, J C Wang, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Effects of yeast DNA topoisomerase III on telomere structure.

J. Wang, P. Caron, R. A. Kim, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Involvement ofhelicase II(uvrD geneproduct) andDNA polymerase Iinexcision mediated bytheuvrABCprotein complex

P. Caron, 1985 .

Macromolecular Physiology of the Escherichia coli UVR Proteins

P. Caron, L. Grossman, S. Mazur, 1989 .

Appendix: Compendium of DNA Topoisomerase Sequences

P. Caron, 1999 .

KLONER; a computer program to simulate recombinant DNA strategies by restriction map manipulation

P. R. Caron, P. Caron, 1984, Nucleic Acids Res..

Transforming the genome to drug discovery.

M. Murcko, P. Caron, 2002, Drug discovery today.