Jian Li

发表

Strategy for discovering chemical inhibitors of human cyclophilin a: focused library design, virtual screening, chemical synthesis and bioassay.

Jian Zhang, Xiaomin Luo, Weiliang Zhu, 2006, Journal of combinatorial chemistry.

Discovering novel chemical inhibitors of human cyclophilin A: Virtual screening, synthesis, and bioassay

Hualiang Jiang, Xu Shen, Hong Liu, 2005, Bioorganic & Medicinal Chemistry.

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

Hualiang Jiang, Yechun Xu, Jian Li, 2020, Science.

Structure of the CCR5 Chemokine Receptor–HIV Entry Inhibitor Maraviroc Complex

Hualiang Jiang, R. Stevens, Jian Li, 2013, Science.

Design, synthesis and antitumor evaluation of a new series of N-substituted-thiourea derivatives

Jian Li, Hong Liu, Bing Xiong, 2006, Acta Pharmacologica Sinica.

Binding interaction of quercetin-3-β-galactoside and its synthetic derivatives with SARS-CoV 3CLpro: Structure–activity relationship studies reveal salient pharmacophore features

Cheng Luo, Weiliang Zhu, Jian Li, 2006, Bioorganic & Medicinal Chemistry.

Sulfoximines-Assisted Rh(III)-Catalyzed C–H Activation and Intramolecular Annulation for the Synthesis of Fused Isochromeno-1,2-Benzothiazines Scaffolds under Room Temperature

Hong Liu, Jian Li, Chunpu Li, 2020, Molecules.

Synthesis and Evaluation of Anti-HIV-1 Activities of Novel 7-Hydroxy-1,3-dioxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-4-carboxylate Derivatives

Hong Liu, Jian Li, Yu Zhou, 2014 .

DC591017, a phosphodiesterase-4 (PDE4) inhibitor with robust anti-inflammation through regulating PKA-CREB signaling.

Yechun Xu, Jian Li, Heng Li, 2020, Biochemical pharmacology.

A Novel Class of Norovirus Inhibitors Targeting the Viral Protease with Potent Antiviral Activity In Vitro and In Vivo

Jian Li, J. Neyts, Hong Liu, 2021, Viruses.

Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment.

Yechun Xu, Jian Li, Heng Li, 2020, European journal of medicinal chemistry.

In vitro and in vivo evaluation of the main protease inhibitor FB2001 against SARS-CoV-2

Jian Li, Wenhao Dai, H. Su, 2022, Antiviral Research.

a new 4 th generation FloTrac algorithm to track cardiac output changes in patients receiving phenylephrine

Jian Li, Hong Liu, N. Fleming, 2014 .

Design, synthesis and biological evaluation of novel 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of the epidermal growth factor receptor.

Hualiang Jiang, Xu Zhang, Jian Li, 2013, Bioorganic & medicinal chemistry.

Structure-Based Design of Tropane Derivatives as a Novel Series of CCR5 Antagonists with Broad-Spectrum Anti-HIV-1 Activities and Improved Oral Bioavailability.

Jian Li, Liang-zhong Chen, Hong Liu, 2022, Journal of medicinal chemistry.

LC-MS/MS assay of fluoropezil and its two major metabolites in human plasma: an application to pharmacokinetic studies.

Jian Li, Yu Zhou, Xiaoyan Chen, 2022, Bioanalysis.

Sulfoximines Assisted Rh(III)-Catalyzed C-H Activation/Annulation Cascade to Synthesize Highly Fused Indeno-1,2-benzothiazines.

Hong Liu, Jian Li, Yu Zhou, 2021, The Journal of organic chemistry.

Rh(III)-Catalyzed C-H Cyclization of Arylnitrones with Diazo Compounds: Access to 3-Carboxylate Substituted N-Hydroxyindoles.

Jian Li, Yu Zhou, Hong Liu, 2017, The Journal of organic chemistry.

Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2

Kaixian Chen, Hualiang Jiang, Yechun Xu, 2021, Journal of medicinal chemistry.

Direct Synthesis of 3-Acylindoles through Rhodium(III)-Catalyzed Annulation of N-Phenylamidines with α-Cl Ketones.

Hong Liu, Jian Li, Yu Zhou, 2018, Organic letters.

Microwave‐Assisted Dehalogenation of α‐Haloketones by Zinc and Ammonium Chloride in Alcohol

Hualiang Jiang, Hong Liu, Xiao-min Luo, 2008 .

Microwave‐Assisted Dehalogenation of α‐Haloketones by Zinc and Ammonium Chloride in Alcohol.

Hualiang Jiang, Hong Liu, Xiao-min Luo, 2008 .

Microwave‐Assisted Synthesis of 2‐Amino‐thiophene‐3‐Carboxylic Derivatives Under Solvent‐Free Conditions

Hualiang Jiang, Jianhua Shen, Hong Liu, 2005 .

Metal-free tandem reaction in water: An efficient and regioselective synthesis of 3-hydroxyisoindolin-1-ones

Hualiang Jiang, Hong Liu, Jian Li, 2010 .

Construction of highly enantioenriched spirocyclopentaneoxindoles containing four consecutive stereocenters via thiourea-catalyzed asymmetric Michael–Henry cascade reactions

Hong Liu, Jian Li, Yu Zhou, 2017, Beilstein journal of organic chemistry.

An unusual de-nitro reduction of 2-substituted-4-nitroquinolines

Hualiang Jiang, Hong Liu, Jian Li, 2006 .

Microwave‐Assisted Synthesis of 2‐Aminothiophene‐3‐carboxylic Derivatives under Solvent‐Free Conditions.

Hualiang Jiang, Jianhua Shen, Hong Liu, 2005 .

One novel quinoxaline derivative as a potent human cyclophilin A inhibitor shows highly inhibitory activity against mouse spleen cell proliferation

Li Zhang, Yu Qin, Jingkang Shen, 2006, Bioorganic & Medicinal Chemistry.

Synthesis of C-4-modified zanamivir analogs as neuraminidase inhibitors and their anti-AIV activities.

Weiliang Zhu, Jian Li, Ky-Youb Nam, 2012, European journal of medicinal chemistry.

Structure-Based Design, Synthesis and Biological Evaluation of Peptidomimetic Aldehydes as a Novel Series of Antiviral Drug Candidates Targeting the SARS-CoV-2 Main Protease

Hualiang Jiang, Yechun Xu, Jian Li, 2020, bioRxiv.

Syntheses of triazole-modified zanamivir analogues via click chemistry and anti-AIV activities.

Weiliang Zhu, Jian Li, Mingyue Zheng, 2006, Bioorganic & medicinal chemistry letters.

Recent Advances in Neuraminidase Inhibitor Development as Anti‐influenza Drugs

Fei Zhao, Mingyue Zheng, Rolf Hilgenfeld, 2012, ChemMedChem.

Design, synthesis and biological evaluation of novel 6-alkenylamides substituted of 4-anilinothieno[2,3-d]pyrimidines as irreversible epidermal growth factor receptor inhibitors.

Jian Li, Xun Ji, Hualiang Jiang, 2014, Bioorganic & medicinal chemistry.

Structure-based design and synthesis of C-1- and C-4-modified analogs of zanamivir as neuraminidase inhibitors.

Weiliang Zhu, Jian Li, Mingyue Zheng, 2013, Journal of medicinal chemistry.

Molecular binding mode of PF-232798, a clinical anti-HIV candidate, at chemokine receptor CCR5

Jian Li, Qiang Zhao, Hong Liu, 2018, Acta Pharmacologica Sinica.

Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.

Rui Zhang, Heng Li, Xianglei Zhang, 2019, Journal of medicinal chemistry.

Simultaneous Stereoselective 4-Amination with Cyclic Secondary Amines and 2-O-Deacetylation of Peracetylated Sialic Acid Derivatives.

Hualiang Jiang, Hong Liu, Jian Li, 2007 .

Simultaneous stereoselective 4-amination with cyclic secondary amines and 2-O-deacetylation of peracetylated sialic acid derivatives

Hualiang Jiang, Hong Liu, Jian Li, 2007 .

Synthesis and Anti-HIV-1 Activity Evaluation for Novel 3a,6a-Dihydro-1H-pyrrolo[3,4-c]pyrazole-4,6-dione Derivatives

Hong Liu, Jian Li, Yu Zhou, 2016, Molecules.

Antitumor Activity of a New N-Substituted Thiourea Derivative, an EGFR Signaling-Targeted Inhibitor against a Panel of Human Lung Cancer Cell Lines

Xiao-min Luo, Jian Li, C. Mei, 2008, Chemotherapy.

Rh-Catalyzed C-H Activation/Annulation of Enaminones and Cyclic 1,3-Dicarbonyl Compounds: An Access to Isocoumarins.

Jian Li, Yu Zhou, Hong Liu, 2023, The Journal of organic chemistry.

Discovery, synthesis and mechanism study of 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2

Lu Liu, Jian Li, Fang Bai, 2023, European Journal of Medicinal Chemistry.

Discovery and Mechanism Study of SARS-CoV-2 3C-like Protease Inhibitors with a New Reactive Group.

Hui Li, Jian Li, Hong Liu, 2023, Journal of medicinal chemistry.

Structure of the CCR5 Chemokine Receptor–HIV Entry Inhibitor Maraviroc Complex

Hualiang Jiang, R. Stevens, Jian Li, 2013, Science.

Synthesis of C-4-modified zanamivir analogs as neuraminidase inhibitors and their anti-AIV activities.

Hualiang Jiang, Ning Li, Hong Liu, 2012, European journal of medicinal chemistry.