C. Fishwick

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The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.

Timo Heikkilae, S. Thirumalairajan, M. Davies, 2006, Bioorganic & medicinal chemistry letters.

Structure-based discovery of antibacterial drugs

C. Fishwick, K. Simmons, I. Chopra, 2010, Nature Reviews Microbiology.

The Growing Role of Electron Microscopy in Anti-parasitic Drug Discovery.

C. Fishwick, R. Johnson, S. Rawson, 2019, Current medicinal chemistry.

The potential use of single-particle electron microscopy as a tool for structure-based inhibitor design

C. Fishwick, R. Johnson, S. Rawson, 2017, Acta crystallographica. Section D, Structural biology.

CSGID Solves Structures and Identifies Phenotypes for Five Enzymes in Toxoplasma gondii

C. Fishwick, D. Roos, Dhanasekaran Shanmugam, 2018, Front. Cell. Infect. Microbiol..

Discovery of novel FabF ligands inspired by platensimycin by integrating structure-based design with diversity-oriented synthetic accessibility.

C. Fishwick, A. Nelson, M. Fisher, 2014, Organic & biomolecular chemistry.

A virtual high-throughput screening approach to the discovery of novel inhibitors of the bacterial leucine transporter, LeuT

C. Fishwick, A. Johnson, K. Simmons, 2013, Molecular membrane biology.

Identification of Selective Inhibitors of the Potassium Channel Kv1.1–1.2(3) by High-Throughput Virtual Screening and Automated Patch Clamp

Wiktor Jurkowski, Erik Lindahl, Bert L de Groot, 2012, ChemMedChem.

Pregnenolone sulphate-independent inhibition of TRPM3 channels by progesterone

C. Fishwick, D. O'regan, K. Porter, 2012, Cell calcium.

Refining the chemical toolbox to be fit for educational and practical purpose for drug discovery in the 21st Century.

C. Fishwick, M. Lolli, K. Pors, 2015, Drug discovery today.

Structure‐based design of anti‐infectives

C. Fishwick, Anil K. Agarwal, Anil K Agarwal, 2010, Annals of the New York Academy of Sciences.

contains a recognition site for the fibrinogen 2 The activation peptide cleft exposed by thrombin cleavage of FXIII-A

C. Fishwick, P. Adamson, R. Pease, 2013 .

The activation peptide cleft exposed by thrombin cleavage of FXIII-A(2) contains a recognition site for the fibrinogen α chain.

C. Fishwick, P. Adamson, R. Pease, 2013, Blood.

Design and synthesis of new hydroxyethylamines as inhibitors of D-alanyl-D-lactate ligase (VanA) and D-alanyl-D-alanine ligase (DdlB).

Samo Turk, Stanislav Gobec, C. Fishwick, 2009, Bioorganic & medicinal chemistry letters.

Structure guided development of potent reversibly binding penicillin binding protein inhibitors.

A. Luxen, C. Fishwick, E. Sauvage, 2011, ACS medicinal chemistry letters.

Factors influencing the specificity of inhibitor binding to the human and malaria parasite dihydroorotate dehydrogenases.

M. R. Parsons, C. Fishwick, A. Johnson, 2012, Journal of medicinal chemistry.

Computational Methods to Identify New Antibacterial Targets

C. Fishwick, K. Simmons, M. McPhillie, 2015, Chemical biology & drug design.

Cover Picture: Identification of Selective Inhibitors of the Potassium Channel Kv1.1–1.2(3) by High-Throughput Virtual Screening and Automated Patch Clamp (ChemMedChem 10/2012)

Bert L. de Groot, A. Peter Johnson, Erik Lindahl, 2012 .

Studies on the inhibition of AmpC and other β-lactamases by cyclic boronates.

Samuel T. Cahill, C. Fishwick, C. Schofield, 2019, Biochimica et biophysica acta. General subjects.

Benzothioxalone derivatives as novel inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferases (MurA and MurZ).

C. Fishwick, K. Simmons, I. Chopra, 2010, The Journal of antimicrobial chemotherapy.

Adhirons inhibit immune complex binding to FcγRIIIa with high specificity through competitive and allosteric modes of action. Authors

Mark P. Waterhouse, A. Goldman, R. Owens, 2018 .

Sequential azomethine imine cycloaddition–palladium catalysed cyclisation processes

C. Fishwick, R. Grigg, V. Sridharan, 2003 .

Hetero-1,3-dipolar cycloadditions of dithiolane-isocyanate imminium methylides: A novel route to 1,3-oxazolidine- and thiazolidine-2-thiones

C. Fishwick, Richard Foster, R. Carr, 1996 .

Structure-guided enhancement of selectivity of chemical probe inhibitors targeting bacterial seryl-tRNA synthetase

C. Fishwick, L. Czaplewski, D. Scott, 2019, bioRxiv.

Structural and mechanistic studies reveal the effectiveness of non-classical (cid:533) -lactamase 1 inhibitors against extensively drug resistant Stenotrophomonas maltophilia.

Samar, C. Fishwick, K. Heesom, 2018 .

An in silico structure-based approach to anti-infective drug discovery

C. Fishwick, A. Johnson, Fraser Cunningham, 2013, Parasitology.

Fibrinogen interaction with complement C3: a potential therapeutic target to reduce thrombosis risk

C. Fishwick, M. McPherson, K. Simmons, 2020, Haematologica.

2-Aminotetralones: novel inhibitors of MurA and MurZ.

C. Fishwick, S. Phillips, I. Chopra, 2008, Bioorganic & medicinal chemistry letters.

Adsorption and self-assembly of peptides on mica substrates.

R. W. Owens, C. Fishwick, Jiyu Fang, 2005, Angewandte Chemie.

Structure-Based Identification and Characterization of Inhibitors of the Epilepsy-Associated KNa1.1 (KCNT1) Potassium Channel

C. Fishwick, S. Muench, J. Lippiat, 2020, iScience.

(±) cis-Bisamido epoxides: A novel series of potent FXIII-A inhibitors.

C. Fishwick, R. Pease, P. Grant, 2015, European journal of medicinal chemistry.

Structure-based ligand design of novel bacterial RNA polymerase inhibitors.

C. Fishwick, A. Johnson, I. Chopra, 2011, ACS medicinal chemistry letters.

Hyperreactivity of adenines and conformational flexibility of a translational repression site

C. Fishwick, I. Haneef, P. Stockley, 1991, FEBS letters.

Molecular mechanism of ligand recognition by membrane transport protein, Mhp1

C. Fishwick, A. Johnson, S. Iwata, 2014, The EMBO journal.

Discovery of novel non-peptide inhibitors of BACE-1 using virtual high-throughput screening.

C. Fishwick, A. Johnson, N. Hooper, 2009, Bioorganic & medicinal chemistry letters.

Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates

Samuel T. Cahill, C. Fishwick, C. Schofield, 2016, Nature Communications.

A facile palladium catalysed 3-component cascade route to functionalised isoquinolinones and isoquinolines.

C. Fishwick, R. Grigg, M. F. Aly, 2016, Chemical communications.

Applications of structure-based design to antibacterial drug discovery.

C. Fishwick, K. Simmons, M. McPhillie, 2014, Bioorganic chemistry.

De Novo Design of Type II Topoisomerase Inhibitors as Potential Antimicrobial Agents Targeting a Novel Binding Region

C. Fishwick, M. McPhillie, A. Maxwell, 2021 .

Encapsulation of sodium alkyl sulfates by the cyclotriveratrylene-based, [Pd(6)L(8)](12+) stella octangula cage.

C. Fishwick, J. Fisher, M. Hardie, 2014, Dalton transactions.

Facile palladium catalysed functionalisation of 1,2-isothiazoline-3-ones and the highly diastereoselective Diels-Alder reactions of 4-vinyl-1,2-isothiazoline-3-one-1-oxides

C. Fishwick, A. Bell, J. E. Reed, 1999 .

Facile palladium catalysed functionalisation of 1,2-isothiazoline-3-ones

C. Fishwick, A. Bell, J. E. Reed, 1994 .

Generation and reactions of azaxylylenes

C. Fishwick, R. Bowen, R. C. Storr, 1982 .

A simple route to C-functionalised azaxylylenes and diazaxylylenes

C. Fishwick, P. Manley, R. C. Storr, 1984 .

Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase.

Timo Heikkilae, M. Davies, C. Fishwick, 2007, Journal of medicinal chemistry.

Structures of Helical β-Tapes and Twisted Ribbons: The Role of Side-Chain Interactions on Twist and Bend Behavior

C. Fishwick, N. Boden, C. Whitehouse, 2003 .

pH as a trigger of peptide beta-sheet self-assembly and reversible switching between nematic and isotropic phases.

S. Radford, C. Fishwick, A. Aggeli, 2003, Journal of the American Chemical Society.

Neighbouring group effects in a Pummerer-type rearrangement: A facile entry into 3,1-benzoxathiins

C. Fishwick, J. Findlay, P. Ward, 1995 .

Neighbouring group participation in Pummerer-type rearrangements of ortho-substituted arylmethyl sulphoxides

C. Fishwick, J. Findlay, P. Ward, 1995 .

Stereoselective palladium-catalyzed four-component cascade synthesis of pyrrolidinyl-, pyrazolidinyl-, and isoxazolidinyl isoquinolines.

C. Fishwick, R. Grigg, C. Kilner, 2005, Angewandte Chemie.

Catalytic bimetalic [Pd(0)/Ag(I) Heck-1,3-dipolar cycloaddition cascade reactions accessing spiro-oxindoles. Concomitant in situ generation of azomethine ylides and dipolarophile

C. Fishwick, R. Grigg, C. Kilner, 2018, Tetrahedron.

Dithiolane-isocyanate imminium methylides: A rapid stereoselective entry into γ-lactams

C. Fishwick, Richard Foster, R. Carr, 1995 .

Generation and cycloadditions of 2-(N-acylamino)-1-thia-1,3-dienes part III: Control of diastereoselectivity using homochiral auxiliaries

C. Fishwick, A. Bell, J. E. Reed, 1998 .

Generation and cycloadditions of 2-(N-Acylamino)-1-thia-1,3-dienes. Part II. Rationalization of reactivity using an FMO approach.

C. Fishwick, D. Hill, I. T. Barnish, 1989 .

Tris-N-alkylpyridinium-functionalised cyclotriguaiacylene hosts as axles in branched [4]pseudorotaxane formation

C. Fishwick, K. Simmons, M. Hardie, 2017 .

1,3-Dipolar cycloaddition of stabilised and non-stabilised azomethine ylides derived from uracil polyoxin C (UPoC): access to nikkomycin analogues

C. Fishwick, R. Grigg, C. Kilner, 2004 .

Three-component bimetallic (Pd/In) mediated cascade allylation of C=X functionality: Part 1. Scope and Class 1 examples with aldehydes and ketones

C. Fishwick, R. Grigg, Laura A. T. Cleghorn, 2003 .

XY–ZH compounds as potential 1,3-dipoles. Part 65: atom economic cascade synthesis of highly functionalized pyrimidinylpyrrolidines

C. Fishwick, R. Grigg, M. F. Aly, 2011 .

A short dipolar cycloaddition approach to γ-lactam alkaloids from cynometra hankei

C. Fishwick, Richard Foster, R. Carr, 1996 .

Pyridine-3-carboxamide-6-yl-ureas as novel inhibitors of bacterial DNA gyrase: structure based design, synthesis, SAR and antimicrobial activity.

C. Fishwick, D. Davies, L. Czaplewski, 2014, European journal of medicinal chemistry.

Pd(0) catalyzed three–five-component C-2-arylallylation of active methylene heterocycles: pyrazolones, oxazolones, isoxazolones and N,N′-dimethylbarbituric acid

C. Fishwick, R. Grigg, V. Sridharan, 2007 .

γ-Carboline AC190 analogues via palladium catalysed allene insertion stereo and regioselective 3- and 5-component cascades

C. Fishwick, R. Grigg, C. Kilner, 2016 .

Synthesis of Pyrrolidinyl, Pyrazolidinyl, and Isoxazolidinyl Isoquinolines

C. Fishwick, R. Grigg, C. Kilner, 2006 .

New insights into the binding mode of pyridine-3-carboxamide inhibitors of E. coli DNA gyrase.

C. Fishwick, C. Stevenson, D. Lawson, 2019, Bioorganic & medicinal chemistry.

The azomethine ylide strategy for β-lactam synthesis. An evaluation of alternative pathways for azomethine ylide generation

C. Fishwick, N. Hales, T. Gallagher, 2001 .

The azomethine ylide strategy for β-lactam synthesis. A comprehensive mechanistic evaluation

C. Fishwick, N. Hales, T. Gallagher, 2001 .

Enantioselective synthesis of non-proteinogenic 2-arylallyl-α-amino acids via Pd/In catalytic cascades

C. Fishwick, R. Grigg, S. R. Korn, 2006 .

The synthesis and reactivity of optically pure amino acids bearing side-chain thioamides

C. Fishwick, J. M. Sanderson, J. Findlay, 2000 .

Preparation of novel 3H-trifluoromethyldiazirine-based photoactivatable potassium channel antagonists

C. Fishwick, J. M. Sanderson, J. Findlay, 2005 .

Photoactivatable analogues of a Substance P non-peptidic antagonist, for probing the antagonist binding site of the NK1 receptor

C. Fishwick, J. Findlay, P. Ward, 1995 .

The reaction of benzyne with imines

C. Fishwick, R. C. Storr, R. Gupta, 1985 .

Highly efficient diastereoselective Exo Diels-Alder reactions of homochiral 2-(N-acylamino)-1-thia-1,3-dienes: A powerful entry into optically pure thiopyrans

C. Fishwick, A. Bell, J. E. Reed, 1996 .

Remarkably high diastereoselective exo diels-alder reactivity of 4-vinyl isothiazoline-3-one-1-oxides: The sulphoxide Syn effect.

C. Fishwick, A. Bell, J. E. Reed, 1995 .

Facile intramolecular cycloadditions of 2-(N-Acylamino)-1-thia-1,3-dienes

C. Fishwick, D. Hill, I. T. Barnish, 1991 .

Generation and cycloadditions of 2-(N-acylamino)-1-thia-1,3-dienes

C. Fishwick, D. Hill, C. Szántay, 1989 .

[3+2] Cycloadditions of indolenine-derived azomethine ylides a rapid entry into pyrrolo [1,2-a] indolines.

Andrew D. Jones, C. Fishwick, C. Szántay, 1988 .

Structure-guided enhancement of selectivity of chemical probe inhibitors targeting bacterial seryl-tRNA synthetase.

C. Fishwick, L. Czaplewski, D. Scott, 2019, Journal of medicinal chemistry.

N-azirin-3-yl and N-indol-3-yl azaxylylenes

C. Fishwick, P. Manley, R. C. Storr, 1985 .

RNA Polymerase Inhibitors with Activity against Rifampin-Resistant Mutants of Staphylococcus aureus

C. Fishwick, I. Chopra, A. O’Neill, 2000, Antimicrobial Agents and Chemotherapy.

Assay Platform for Clinically Relevant Metallo-β-lactamases

R. Owens, C. Fishwick, C. Schofield, 2013, Journal of medicinal chemistry.

High-Risk Human Papillomavirus E5 Oncoprotein Displays Channel-Forming Activity Sensitive to Small-Molecule Inhibitors

C. Fishwick, G. Blair, N. Stonehouse, 2012, Journal of Virology.

Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy

D. Bonthron, C. Fishwick, A. Latos-Bieleńska, 2008, Nature Genetics.

An efficient route to S-N-(9-fluorenylmethoxycarbonyl)-4′-(1-azi-2,2,2-trifluoroethyl)phenylalanine

C. Fishwick, J. M. Sanderson, J. Findlay, 1994 .

Discovery of Membrane-Bound Pyrophosphatase Inhibitors Derived from an Isoxazole Fragment

A. Goldman, C. Fishwick, S. Meri, 2020, ACS medicinal chemistry letters.

Selective Phosphonylation of 5′-Adenosine Monophosphate (5′-AMP) via Pyrophosphite [PPi(III)]

D. E. Bryant, C. Fishwick, T. Kee, 2016, Origins of Life and Evolution of Biospheres.

The nature of Staphylococcus aureus MurA and MurZ and approaches for detection of peptidoglycan biosynthesis inhibitors

C. Fishwick, K. Simmons, I. Chopra, 2009, Molecular microbiology.

A Non-peptidic photoactivatable antagonist for mapping the antagonist binding site of the tachykinin NK2 receptor

C. Fishwick, D. Donnelly, J. Findlay, 1996 .

An Efficient Route to (S)-N-(9-Fluorenylmethoxycarbonyl)-4′-(1-azi-2,2, 2-trifluoroethyl)phenylalanine.

C. Fishwick, J. M. Sanderson, J. Findlay, 1994 .

Self-assembling β-Sheet Tape Forming Peptides

C. Fishwick, T. McLeish, A. Aggeli, 2006 .

Novel Generation and Regio- and Stereospecific 1,3-Dipolar Cycloaddition of 2-Ethoxycarbonyl-3,3-dimethyl-3H-indolium-1-methanide

Andrew D. Jones, C. Fishwick, D. Eggleston, 1990 .

Macrocyclic inhibitors of the bacterial cell wall biosynthesis enzyme MurD.

C. Fishwick, A. Johnson, S. Phillips, 2003, Bioorganic & medicinal chemistry letters.

Novel Generation and Regio- and Stereospecific 1,3-Dipolar Cycloaddition of 2-Ethoxycarbonyl-3,3-dimethyl-3H-indolium 1-Methanide.

Andrew D. Jones, C. Fishwick, D. Eggleston, 1990 .

THE PREPARATION OF A 3'-(2-CYANOETHYL)PHOSPHORAMIDITE OF 5'-O-(3-THIOPROPYL)METHYLPHOSPHORYLTHYMIDINE

C. Fishwick, K. J. Percival, 1995 .

The Preparation of a 3′-(2-Cyanoethyl)phosphoramidite of 5′-O-(3- Thiopropyl)methylphosphorylthymidine.

C. Fishwick, K. J. Percival, 1996 .

Use of synthetic oligoribonucleotides to probe RNA-protein interactions in the MS2 translational operator complex.

C. Fishwick, P. Stockley, S. Talbot, 1990, Nucleic acids research.

Resistance mutations define specific antiviral effects for inhibitors of the hepatitis C virus p7 ion channel

C. Fishwick, S. Weinman, Matthew J. Bentham, 2011, Hepatology.

Facile preparation of 2-imino tetrahydrofurans, pyrans and oxepans

C. Fishwick, A. Alanine, C. Szántay, 1989 .

Docking of competitive inhibitors to the P2X7 receptor family reveals key differences responsible for changes in response between rat and human

C. Fishwick, S. Baldwin, K. Simmons, 2015, Bioorganic & medicinal chemistry letters.

Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C β-Lactamase from Escherichia coli

C. Fishwick, M. Page, C. Schofield, 2020, Biomolecules.

New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections

L. Hood, C. Fishwick, J. Dubey, 2016, Scientific Reports.

Recent developments in the structural characterisation of the IR and IGF1R: implications for the design of IR–IGF1R hybrid receptor modulators

C. Fishwick, M. Kearney, K. Simmons, 2022, RSC medicinal chemistry.

Molecular Genetic and Structural Modeling Studies of Staphylococcus aureus RNA Polymerase and the Fitness of Rifampin Resistance Genotypes in Relation to Clinical Prevalence

C. Fishwick, I. Chopra, T. Huovinen, 2006, Antimicrobial Agents and Chemotherapy.

Identification of Receptor Tyrosine Kinase Inhibitors Using Cell Surface Biotinylation and Affinity Isolation.

C. Fishwick, S. Ponnambalam, J. Kankanala, 2015, Methods in molecular biology.

Novel synthesis of calamitic and discotic liquid crystalline derivatives of tetrathiafulvalene (TTF)

B. Movaghar, C. Fishwick, R. A. Bissell, 1998 .

X-ray and cryo-EM structures of inhibitor-bound cytochrome bc 1 complexes for structure-based drug discovery

Shaun Rawson, S. Samar Hasnain, Svetlana V. Antonyuk, 2018, IUCrJ.

High-Risk Human Papillomavirus E 5 Oncoprotein Displays Channel-Forming Activity Sensitive to Small-Molecule Inhibitors

C. Fishwick, G. Blair, N. Stonehouse, 2012 .

High-risk human papillomavirus E 5 oncoprotein displays channel-7 forming activity sensitive to small molecule inhibitors

C. Fishwick, G. Blair, N. Stonehouse, 2012 .

Identification of a small molecule inhibitor of Ebola virus genome replication and transcription using in silico screening

C. Fishwick, T. Edwards, J. Barr, 2018, Antiviral research.

Novel Synthesis of Calamitic and Discotic Liquid Crystalline Derivatives of Tetrathiafulvalene (TTF).

B. Movaghar, C. Fishwick, R. A. Bissell, 1998 .

Analysis of Mupirocin Resistance and Fitness in Staphylococcus aureus by Molecular Genetic and Structural Modeling Techniques

C. Fishwick, E. Ingham, I. Chopra, 2004, Antimicrobial Agents and Chemotherapy.

Facile Palladium-Catalyzed Functionalization of 1,2-Isothiazoline-3- ones.

C. Fishwick, A. Bell, J. E. Reed, 1995 .

Facile Palladium-Catalyzed Functionalization of 1,2-Isothiazoline-3-ones and the Highly Diastereoselective Diels—Alder Reactions of 4-Vinyl-1,2-isothiazoline-3-one-1-oxides.

C. Fishwick, A. Bell, J. E. Reed, 2000 .

Cyclic Boronates Inhibit All Classes of β-Lactamases

Samuel T. Cahill, C. Fishwick, C. Schofield, 2017, Antimicrobial Agents and Chemotherapy.

Cyclic Boronates Inhibit All Classes of -Lactamases. Antimicrobial

Samuel T. Cahill, C. Fishwick, C. Schofield, 2016 .

Structural/mechanistic insights into the efficacy of nonclassical β‐lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates

C. Fishwick, C. Schofield, K. Heesom, 2017, Molecular microbiology.

Affimer proteins inhibit immune complex binding to FcγRIIIa with high specificity through competitive and allosteric modes of action

Mark P. Waterhouse, A. Goldman, R. Owens, 2017, Proceedings of the National Academy of Sciences.

Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness

M. Nardini, M. Bolognesi, C. Fishwick, 2018 .

Developments in Non-Intercalating Bacterial Topoisomerase Inhibitors: Allosteric and ATPase Inhibitors of DNA Gyrase and Topoisomerase IV

C. Fishwick, M. McPhillie, S. Grossman, 2023, Pharmaceuticals.

A small molecule reveals role of insulin receptor-insulin like growth factor-1 receptor heterodimers

C. Fishwick, M. Kearney, K. Simmons, 2021, bioRxiv.

Structure-based identification and characterisation of novel inhibitors of KNa1.1 potassium channels, a stratified target for KCNT1-related epilepsy

C. Fishwick, S. Muench, J. Lippiat, 2019, bioRxiv.

A chemical genomics approach to drug reprofiling in oncology: Antipsychotic drug risperidone as a potential adenocarcinoma treatment.

C. Fishwick, A. Clark, P. Taylor, 2017, Cancer letters.

A study of the effects of substituents on the selectivity of the binding of N-arylaminomethylene malonate inhibitors to DHODH.

C. Fishwick, A. Johnson, G. McConkey, 2010, Bioorganic & medicinal chemistry letters.

Natural and synthetic flavonoid modulation of TRPC5 channels

Jing Li, Hussein N. Rubaiy, David J Beech, 2016, British journal of pharmacology.

Activity of and Development of Resistance to Corallopyronin A, an Inhibitor of RNA Polymerase

C. Fishwick, I. Chopra, M. McPhillie, 2011, Antimicrobial Agents and Chemotherapy.

Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine

V. Fülöp, C. Fishwick, K. Simmons, 2017, Nature Communications.

New Opportunities in the Structure-based Design of Anti-Protozoan Agents.

C. Fishwick, M. McPhillie, Colin W G Fishwick, 2016, Current topics in medicinal chemistry.

Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases.

M. Davies, M. R. Parsons, C. Fishwick, 2009, Journal of medicinal chemistry.

Synthesis of de novo designed small-molecule inhibitors of bacterial RNA polymerase

Colin W. G. Fishwick, C. Fishwick, A. Johnson, 2008 .

Furanyl-Rhodanines Are Unattractive Drug Candidates for Development as Inhibitors of Bacterial RNA Polymerase

Colin W. G. Fishwick, C. Fishwick, I. Chopra, 2010, Antimicrobial Agents and Chemotherapy.

Author Correction: New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections

L. Hood, C. Fishwick, J. Dubey, 2020, Scientific Reports.

Structure-based identification and characterisation of structurally novel human P2X7 receptor antagonists

C. Fishwick, S. Muench, Lin-Hua Jiang, 2016, Biochemical pharmacology.

Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay.

Joel S. Freundlich, D. Rice, C. Fishwick, 2013, Biochemistry.

In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors.

Samuel T. Cahill, C. Fishwick, P. McHugh, 2018, Journal of medicinal chemistry.

Derivatives of pyrimidine, phthalimide and anthranilic acid as inhibitors of human hydroxysteroid dehydrogenase AKR1C1.

M. Davies, C. Fishwick, A. Johnson, 2009, Chemico-biological interactions.

Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design.

Nigel M Hooper, C. Fishwick, A. Johnson, 2013, Journal of medicinal chemistry.

Adenosine tetraphosphoadenosine drives a continuous ATP-release assay for aminoacyl-tRNA synthetases and other adenylate-forming enzymes.

C. Fishwick, A. Lloyd, C. Dowson, 2013, ACS chemical biology.

Generation and cycloadditions of 2-(N-acylamino)-1-thia-1, 3-dienes. Structural investigations using NMR methods. Part I.

C. Fishwick, D. Hill, C. Szántay, 1989 .

Linezolid and Tiamulin Cross-Resistance in Staphylococcus aureus Mediated by Point Mutations in the Peptidyl Transferase Center

C. Fishwick, I. Chopra, K. Miller, 2008, Antimicrobial Agents and Chemotherapy.

Potent Tetrahydroquinolone Eliminates Apicomplexan Parasites

C. Fishwick, K. El Bissati, C. Roberts, 2020, Frontiers in Cellular and Infection Microbiology.

Determinants of Hepatitis C Virus p7 Ion Channel Function and Drug Sensitivity Identified In Vitro

C. Fishwick, D. Rowlands, S. Griffin, 2009, Journal of Virology.

From Fragment to Lead: De Novo Design and Development toward a Selective FGFR2 Inhibitor.

C. Fishwick, M. Knowles, J. Burns, 2021, Journal of medicinal chemistry.

From Fragment to Lead: A Structure-Guided Approach Towards a Selective FGFR2 Inhibitor

C. Fishwick, M. Knowles, J. Burns, 2021 .

Epoxide based inhibitors of the hepatitis C virus non-structural 2 autoprotease

C. Fishwick, Joseph Shaw, M. Harris, 2015, Antiviral research.

The First Small-Molecule Inhibitors of Members of the Ribonuclease E Family

C. Fishwick, Deena M. A. Gendoo, S. Jourdan, 2015, Scientific Reports.

Two novel amino acid derivatives containing side-chain thioamides for the synthesis of photoactivatable peptides

C. Fishwick, J. Findlay, Preeti Singh, 1997 .

Inhibition of complement C3 and fibrinogen interaction: a potential novel therapeutic target to reduce cardiovascular disease in diabetes

C. Fishwick, K. Simmons, R. Ajjan, 2015, The Lancet.

Analysis of mutational resistance to trimethoprim in Staphylococcus aureus by genetic and structural modelling techniques.

C. Fishwick, I. Chopra, A. O’Neill, 2009, The Journal of antimicrobial chemotherapy.

X=Y–ZH system as potential 1,3-dipoles. Part 59: Cascade 1,3-azaprotio cyclotransfer–1,3-dipolar cycloaddition (1,3-APT–1,3-DC) reactions of benzobicyclo[3.3.1]non-5-en-9-one oxime

C. Fishwick, R. Grigg, M. Thornton-Pett, 2003 .

Hetero-1,3-Dipolar Cycloadditions of Dithiolane-Isocyanate Imminium Methylides: A Novel Route to 1,3-Oxazolidine- and Thiazolidine-2- thiones.

C. Fishwick, Richard Foster, R. Carr, 1996 .

A de novo designed inhibitor of D-Ala-D-Ala ligase from E. coli.

C. Fishwick, A. Johnson, I. Chopra, 2005, Angewandte Chemie.

Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine

V. Fülöp, C. Fishwick, K. Simmons, 2017, Nature Communications.

In Silico Design and Biological Evaluation of a Dual Specificity Kinase Inhibitor Targeting Cell Cycle Progression and Angiogenesis

C. Fishwick, S. Homer-Vanniasinkam, M. Kearney, 2014, PloS one.

Interconvertible geometric isomers of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors exhibit multiple binding modes.

C. Fishwick, G. McConkey, Fraser Cunningham, 2017, Bioorganic & medicinal chemistry letters.

Generation and cycloadditions of tetrahydrofuryl, pyranyl, and oxepanyl-2-imminium methylides

C. Fishwick, A. Alanine, C. Szántay, 1989 .

The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target.

D. Rice, C. Fishwick, S. Prigge, 2014, Bioorganic & medicinal chemistry letters.

Encapsulation of sodium alkyl sulfates by the cyclotriveratrylene-based, [Pd(6)L(8)](12+) stella octangula cage.

C. Fishwick, J. Fisher, M. Hardie, 2014, Dalton transactions.

A combinatorial in silico and cellular approach to identify a new class of compounds that target VEGFR2 receptor tyrosine kinase activity and angiogenesis

C. Fishwick, S. Homer-Vanniasinkam, S. Ponnambalam, 2012, British journal of pharmacology.

Ozonolytic Cleavage of 3-Oxidopyrilium Betaine-Derived Cycloadducts: Simple and Efficient Access to Stereodefined Tetrahydrofurans

C. Fishwick, G. Mitchell, Peter F. W. Pang, 2005 .

Ozonolytic Cleavage of 3‐Oxidopyrilium Betaine‐Derived Cycloadducts: Simple and Efficient Access to Stereodefined Tetrahydrofurans.

C. Fishwick, G. Mitchell, Peter F. W. Pang, 2005 .

The first de novo-designed antagonists of the human NK(2) receptor.

Nirmala Bhogal, C. Fishwick, J. Findlay, 2005, Journal of medicinal chemistry.

Indolinones and anilinophthalazines differentially target VEGF‐A‐ and basic fibroblast growth factor‐mediated responses in primary human endothelial cells

C. Fishwick, S. Homer-Vanniasinkam, S. Ponnambalam, 2012, British journal of pharmacology.