D. Hattis

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What Should Be the Implications of Uncertainty, Variability, and Inherent “Biases”/“Conservatism” for Risk Management Decision-Making?

Dale Hattis, Elizabeth L. Anderson, D. Hattis, 1999 .

Incorporating pharmacokinetic differences between children and adults in assessing children's risks to environmental toxicants.

Dale Hattis, D. Hattis, B. Sonawane, 2004, Toxicology and applied pharmacology.

Variability in susceptibility - how big, how often, for what responses to what agents?

D. Hattis, 1996, Environmental toxicology and pharmacology.

Human variability in susceptibility

D. Hattis, 1997 .

State-of-the-Science Workshop Report: Issues and Approaches in Low-Dose–Response Extrapolation for Environmental Health Risk Assessment

Ronald H. White, F. Dominici, J. Samet, 2008, Environmental health perspectives.

Population distribution of aldehyde dehydrogenase-2 genetic polymorphism: implications for risk assessment.

D. Hattis, B. Sonawane, G. Ginsberg, 2002, Regulatory toxicology and pharmacology : RTP.

Distributions of Individual Susceptibility among Humans for Toxic Effects: How Much Protection Does the Traditional Tenfold Factor Provide for What Fraction of Which Kinds of Chemicals and Effects?

D. Hattis, R. Goble, P. Banati, 1999, Annals of the New York Academy of Sciences.

Evaluation of child/adult pharmacokinetic differences from a database derived from the therapeutic drug literature.

D. Hattis, B. Sonawane, G. Ginsberg, 2002, Toxicological sciences : an official journal of the Society of Toxicology.

Dose-dependent transitions in mechanisms of toxicity.

Melvin E Andersen, Nancy G Doerrer, Dale Hattis, 2004, Toxicology and applied pharmacology.

Meeting Report: Moving Upstream—Evaluating Adverse Upstream End Points for Improved Risk Assessment and Decision-Making

Amy D. Kyle, Gregory G. Miller, Tracey J. Woodruff, 2008, Environmental health perspectives.

Genetic Polymorphism in N-Acetyltransferase (NAT): Population Distribution of NAT1 and NAT2 Activity

Dale Hattis, Kathryn Z Guyton, D. Hattis, 2009, Journal of toxicology and environmental health. Part B, Critical reviews.

Genetic Polymorphism in Cytochrome P450 2D6 (CYP2D6): Population Distribution of CYP2D6 Activity

Dale Hattis, Patricia Neafsey, D. Hattis, 2009, Journal of toxicology and environmental health. Part B, Critical reviews.

Genetic Polymorphism in CYP2E1: Population Distribution of CYP2E1 Activity

Dale Hattis, Kathryn Z. Guyton, Douglas O. Johns, 2009, Journal of toxicology and environmental health. Part B, Critical reviews.

Scientific Uncertainties and How They Affect Risk Communication

D. Hattis, 1989 .

Variability in PAH‐DNA Adduct Measurements in Peripheral Mononuclear Cells: Implications for Quantitative Cancer Risk Assessment

F. Perera, D. Hattis, R. Santella, 1997, Risk analysis : an official publication of the Society for Risk Analysis.

Differences in Pharmacokinetics Between Children and Adults—II. Children's Variability in Drug Elimination Half‐Lives and in Some Parameters Needed for Physiologically‐Based Pharmacokinetic Modeling

D. Hattis, G. Ginsberg, B. Sonawane, 2003, Risk analysis : an official publication of the Society for Risk Analysis.

Potential New Approaches for Children's Inhalation Risk Assessment

A. Salmon, D. Hattis, B. Sonawane, 2007, Journal of toxicology and environmental health. Part A.

Assessment for Children Pediatric Pharmacokinetic Data: Implications for Environmental Risk

D. Hattis, B. Sonawane, G. Ginsberg, 2006 .

Pediatric pharmacokinetic data: implications for environmental risk assessment for children.

D. Hattis, B. Sonawane, G. Ginsberg, 2004, Pediatrics.

Pharmacokinetic and Pharmacodynamic Factors That Can Affect Sensitivity to Neurotoxic Sequelae in Elderly Individuals

D. Hattis, B. Sonawane, G. Ginsberg, 2005, Environmental health perspectives.

The Role of Skin Absorption as a Route of Exposure to Volatile Organic Compounds in Household Tap Water: A Simulated Kinetic Approach

D. Hattis, H. S. Brown, 1989 .

Exposure Efficiency: Concept and Application to Perchloroethylene Exposure from Dry Cleaners

D Hattis, K M Thompson, J. Evans, 2000, Journal of the Air & Waste Management Association.

Evaluation of the Cardiovascular Effects of Methylmercury Exposures: Current Evidence Supports Development of a Dose–Response Function for Regulatory Benefits Analysis

J. Schwartz, B. Coull, D. Hattis, 2011, Environmental health perspectives.

Cancer risk: Role of environment

D. Hattis, A. Sasco, M. Martuzzi, 2015, Science.

What's Wrong with Quantitative Risk Assessment?

D. Hattis, John A. Smith, 1986, PSA: Proceedings of the Biennial Meeting of the Philosophy of Science Association.

Use of biological markers and pharmacokinetics in human health risk assessment.

D. Hattis, 1991, Environmental health perspectives.

NTP-CERHR expert panel report on the reproductive and developmental toxicity of acrylamide.

Thomas J. Smith, D. Hattis, R. Tice, 2005, Birth defects research. Part B, Developmental and reproductive toxicology.

The Use of Biological Markers in Risk Assessment

D. Hattis, 1988 .

Use of Biological Markers in the Quantitative Assessment of Neurotoxic Risk

D. Hattis, K. Crofton, 1995 .

Human interindividual variability--a major source of uncertainty in assessing risks for noncancer health effects.

D Hattis, D. Hattis, K Silver, 1994, Risk analysis : an official publication of the Society for Risk Analysis.

Methodology for quantitative assessment of risks from chronic respiratory damage: Lung function decline and associated mortality from coal dust

D. Hattis, K. Silver, 1991 .

What Should Be the Implications of Uncertainty, Risk Management Decision-Making?l Variability, and Inherent "Biases 99 / 66 Conservatism" for

D. Hattis, E. Anderson, 1999 .

A Probability-Tree Interpretation of the California EPA’s Analysis of the Cancer Risk from Diesel Particulates

D. Hattis, 1998 .

Risk evaluation: legal requirements, conceptual foundations and practical experiences in the United States - summary

Dale Hattis, D. Hattis, William S. Minkowitz, 1997 .

Summary Minutes of the U.S. Environmental Protection Agency (EPA) Science Advisory Board (SAB) Staff Office Clean Air Scientific Advisory Committee (CASAC) Oxides of Nitrogen Primary NAAQS Review Panel

J. Crapo, F. Speizer, E. Cowling, 2008 .

Robert Goble, Dale Hattis, Margaret Chu, 2005, Environmental health perspectives.

Robert Goble, Dale Hattis, Margaret Chu, 2004, Environmental health perspectives.

Evaluation of the U.S. EPA/OSWER Preliminary Remediation Goal for Perchlorate in Groundwater: Focus on Exposure to Nursing Infants

D. Hattis, D. Rice, G. Ginsberg, 2006, Environmental health perspectives.

Physiologically Based Pharmacokinetic (PBPK) Modeling of Caffeine and Theophylline in Neonates and Adults: Implications for Assessing Children's Risks from Environmental Agents

Dale Hattis, D. Hattis, B. Sonawane, 2004, Journal of toxicology and environmental health. Part A.

Risk evaluation: criteria arising from legal traditions and experience with quantitative risk assessment in the United States.

D Hattis, D. Hattis, W S Minkowitz, 1996, Environmental toxicology and pharmacology.

Letter to U.S. FDA Commissioner

C. Camargo, K. Hooper, D. Hattis, 2007, International journal of occupational and environmental health.

A. Uncertainty and Variability

Dale Hattis, D. Hattis, Elizabeth L. Anderson, 1999 .

Risk assessment and management of chemical contaminants in fishery products consumed in the USA

D. Hattis, F. Ahmed, R. E. Wolke, 1993, Journal of applied toxicology : JAT.

A STRAW MAN PROPOSAL FOR A QUANTITATIVE DEFINITION OF THE RfD

Robert Goble, Dale Hattis, D. Hattis, 2002, Drug and chemical toxicology.

Industrial prospects for chitin and protein from shellfish wastes : a report on the first Marine Industries Business Strategy Program Marine Industry Advisory Service

A. E. Murray, D. Hattis, N. Ash́ford, 1977 .

Dose-dependent transitions in mechanisms of toxicity: case studies.

Melvin E Andersen, Nancy G Doerrer, Dale Hattis, 2004, Toxicology and applied pharmacology.

Genetic Polymorphism in Glutathione Transferases (GST): Population Distribution of GSTM1, T1, and P1 Conjugating Activity

Dale Hattis, Kathryn Z Guyton, D. Hattis, 2009, Journal of toxicology and environmental health. Part B, Critical reviews.

Basic Features of Aging That Can Affect Response to Xenobiotics

D. Hattis, B. Sonawane, G. Ginsberg, 2005 .

A preliminary operational classification system for nonmutagenic modes of action for carcinogenesis.

D Hattis, D. Hattis, N. Rahmioglu, 2009, Critical reviews in toxicology.

Improving Risk Assessment: Research Opportunities in Dose Response Modeling to Improve Risk Assessment

David B. Dunson, Harvey J. Clewell, A. John Bailer, 2002 .

Genetic Polymorphism in Paraoxonase 1 (PON1): Population Distribution of PON1 Activity

Dale Hattis, Kathryn Z Guyton, Patricia Neafsey, 2009, Journal of toxicology and environmental health. Part B, Critical reviews.

Database for Physiologically Based Pharmacokinetic (PBPK) Modeling: Physiological Data for Healthy and Health-Impaired Elderly

Hugh A. Barton, Kannan Krishnan, Chad M. Thompson, 2009, Journal of toxicology and environmental health. Part B, Critical reviews.

Issues in the Design and Interpretation of Chronic Toxicity and Carcinogenicity Studies in Rodents: Approaches to Dose Selection

D. Hattis, R. Conolly, P. Fenner-Crisp, 2007, Critical reviews in toxicology.

Risk assessment for neurobehavioral toxicity: SGOMSEC joint report.

D. Hattis, H. Tilson, B. Ulbrich, 1996, Environmental health perspectives.

Addressing Human Variability in Next-Generation Human Health Risk Assessments of Environmental Chemicals

Weihsueh A. Chiu, Ivan Rusyn, Dale Hattis, 2012, Environmental health perspectives.

The Economic Impact of Early Life Environmental Tobacco Smoke Exposure: Early Intervention for Developmental Delay

F. Perera, D. Hattis, H. Andrews, 2006, Environmental health perspectives.

Health Effects of ETS Exposure

F. Perera, D. Hattis, H. Andrews, 2006 .

The Next Generation of Risk Assessment Multi-Year Study—Highlights of Findings, Applications to Risk Assessment, and Future Directions

Paul A. Schulte, Linda S. Birnbaum, Melvin E. Andersen, 2016, Environmental health perspectives.

Risk Analysis and Society: The Conception of Variability in Risk Analyses: Developments Since 1980

Dale Hattis, D. Hattis, 2003 .

Human variability in susceptibility to toxic chemicals--a preliminary analysis of pharmacokinetic data from normal volunteers.

D Hattis, D. Hattis, M. Ballew, 1987, Risk analysis : an official publication of the Society for Risk Analysis.

Assessing Cumulative Health Risks from Exposure to Environmental Mixtures—Three Fundamental Questions

Ken Sexton, Dale Hattis, D. Hattis, 2007, Environmental health perspectives.

A science-based agenda for health-protective chemical assessments and decisions: overview and consensus statement

Laura N. Vandenberg, Courtney C. Carignan, Roberta F. White, 2023, Environmental Health.

Options for basing Dietary Reference Intakes (DRIs) on chronic disease endpoints: report from a joint US-/Canadian-sponsored working group123

A. Carriquiry, R. Prentice, D. Hattis, 2016, The American journal of clinical nutrition.

The promise of molecular epidemiology for quantitative risk assessment.

D. Hattis, 1986, Risk analysis : an official publication of the Society for Risk Analysis.

The Influence of Genetic Polymorphisms on Population Variability in Six Xenobiotic-Metabolizing Enzymes

Dale Hattis, Kathryn Z Guyton, Patricia Neafsey, 2009, Journal of toxicology and environmental health. Part B, Critical reviews.

The challenge of mechanism-based modeling in risk assessment for neurobehavioral end points.

D. Hattis, 1996, Environmental health perspectives.

10 – Use of Biomarkers in Risk Assessment

D. Hattis, K. Silver, 1993 .

Toxicokinetic interaction of 2,5-hexanedione and methyl ethyl ketone

D. Hattis, J. Froines, E. Landaw, 2001, Archives of Toxicology.

Uncertainties in pharmacokinetic modeling for perchloroethylene: II. Comparison of model predictions with data for a variety of different parameters.

D Hattis, D. Hattis, P. White, 1993, Risk analysis : an official publication of the Society for Risk Analysis.

Role of smoking in low birth weight.

D. Hattis, B. Magee, N. Kivel, 2004, The Journal of reproductive medicine.

Diesel Emissions and Lung Cancer : Epidemiology and Quantitative Risk Assessment

Daniel Krewski, Kyle Steenland, Dale Hattis, 1999 .

Empirically Observed Distributions of Pharmacokinetic and Pharmacodynamic Variability in Humans—Implications for the Derivation of Single-Point Component Uncertainty Factors Providing Equivalent Protection as Existing Reference Doses

Dale Hattis, D. Hattis, Meghan Keaney Lynch, 2016 .

The use of well-defined biomarkers (such as blood lead) in risk assessment

D. Hattis, 1994, Environmental geochemistry and health.

Some Consideration in Choosing an Occupational Noise Exposure Regulation

Nicholas A. Ashford, Dale Hattis, George R. Heaton, 1976 .

Expected values for projected cancer risks from putative genetically acting agents.

D Hattis, D. Hattis, R. Goble, 1991, Risk analysis : an official publication of the Society for Risk Analysis.

Current practice and recommendations for advancing how human variability and susceptibility are considered in chemical risk assessment

Joshua F. Robinson, D. Hattis, T. Woodruff, 2023, Environmental Health.

Are Conundrums with Uncertainty Factors an Obstacle to Developing Probabilistic Interpretations of Noncancer Risks from Chemicals?

Rob Goble, Dale Hattis, D. Hattis, 2010, Risk analysis : an official publication of the Society for Risk Analysis.

Interaction Profile for : Atrazine , Deethylatrazine , Diazinon , Nitrate , and Simazine

Kannan Krishnan, Dale Hattis, Hana R. Pohl, 2006 .

Drawing the Line: Quantitative Criteria for Risk Management

Dale Hattis, D. Hattis, 1996 .

Human Interindividual Variability in Parameters Related to Health Risks

David E. Burmaster, Rob Goble, Dale Hattis, 1999, Risk analysis : an official publication of the Society for Risk Analysis.

Approaches to Acrylamide Physiologically Based Toxicokinetic Modeling for Exploring Child–adult Dosimetry Differences

Dale Hattis, D. Hattis, G. Ginsberg, 2007, Journal of toxicology and environmental health. Part A.

Assessment of Variability and Uncertainty Distributions for Practical Risk Analyses

David E. Burmaster, Dale Hattis, D. Hattis, 1994 .

Human Interindividual Variability in Susceptibility to Airborne Particles

D Hattis, D. Hattis, R. Goble, 2001, Risk analysis : an official publication of the Society for Risk Analysis.

Pharmacokinetic principles for dose-rate extrapolation of carcinogenic risk from genetically active agents.

D Hattis, D. Hattis, 1990, Risk analysis : an official publication of the Society for Risk Analysis.

Linear Low-Dose Extrapolation for Non-Cancer Responses: Burke et al. Respond

Francesca Dominici, Lauren Zeise, Ila Cote, 2009, Environmental Health Perspectives.

Intermediate Effect Biomarkers--Alternatives to Direct Concentration- Response Data for Regulatory Benefits Analyses

D. Hattis, 2011 .

Comparison of contact site cancer potency across dose routes: case study with epichlorohydrin.

D. Hattis, W. Pepelko, G. Ginsberg, 1996, Risk analysis : an official publication of the Society for Risk Analysis.

A Preliminary Operational Classification System for Nonmutagenic Modes of Action for Carcinogenesis

D. Hattis, N. Rahmioglu, R. Goble, 2009 .

The importance of exposure measurements in risk assessment of drugs.

D. Hattis, 1994, Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement.

Improvements in quantitative noncancer risk assessment. Sponsored by the Risk Assessment Specialty Section of the Society of Toxicology.

M L Dourson, D Hattis, B D Beck, 1993, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Uncertainties in pharmacokinetic modeling for perchloroethylene. I. Comparison of model structure, parameters, and predictions for low-dose metabolism rates for models derived by different authors.

D Hattis, D. Hattis, P White, 1990, Risk analysis : an official publication of the Society for Risk Analysis.

Human interindividual variability in susceptibility to toxic effects: from annoying detail to a central determinant of risk.

D Hattis, D. Hattis, 1996, Toxicology.

Distributional Analyses for Children's Inhalation Risk Assessments

Dale Hattis, D. Hattis, 2007, Journal of toxicology and environmental health. Part A.

Moving upstream : evaluating adverse upstream end points for improved risk assessment and decision-making

Gregory G. Miller, D. Hattis, R. Luebke, 2020 .

Three Candidate “Laws” of Uncertainty Analysis1

Dale Hattis, D. Hattis, 1990 .

What Should Be the Implications of Uncertainty, Variability, and Inherent “Biases”/“Conservatism” for Risk Management Decision‐Making? 1

D. Hattis, E. Anderson, 1999 .

Genetic Polymorphism in CYP2E1: Population Distribution of CYP2E1 Activity

D. Hattis, K. Guyton, B. Sonawane, 2009, Journal of toxicology and environmental health. Part B, Critical reviews.

Improvements in Quantitative Noncancer Risk Assessment

Dale Hattis, Michael L. Dourson, Carole A. Kimmel, 1993 .

Database for Physiologically Based Pharmacokinetic (PBPK) Modeling: Physiological Data for Healthy and Health-Impaired Elderly

D. Hattis, B. Sonawane, K. Krishnan, 2009, Journal of toxicology and environmental health. Part B, Critical reviews.

Improving Risk Assessment: Research Opportunities in Dose Response Modeling to Improve Risk Assessment

D. Dunson, D. Hattis, D. Krewski, 2002 .

Needs for public health intervention and needs for new research on vinyl halides and their polymers: a public policy perspective.

D. Hattis, 1981, Environmental health perspectives.

Evaluating Methods for Quantifying Human Noncancer Health Risks: Case Study Application

D. Hattis, E. Post, M. Lynch, 2009 .