P. Howarth

发表

Diary keeping in asthma: comparison of written and electronic methods.

M. Hyland, C. Kenyon, R. Allen, 1993, BMJ.

Stratification of asthma phenotypes by airway proteomic signatures.

C. Auffray, P. Howarth, James P R Schofield, 2019, The Journal of allergy and clinical immunology.

Cigarette Smoke Causes Caspase-Independent Apoptosis of Bronchial Epithelial Cells from Asthmatic Donors

P. Howarth, F. Bucchieri, A. Marino Gammazza, 2015, PloS one.

A Transcriptome‐driven Analysis of Epithelial Brushings and Bronchial Biopsies to Define Asthma Phenotypes in U‐BIOPRED

C. Auffray, P. Howarth, Yike Guo, 2017, American journal of respiratory and critical care medicine.

Genome-Wide Posttranscriptional Dysregulation by MicroRNAs in Human Asthma as Revealed by Frac-seq

M. Niranjan, P. Howarth, R. Chambers, 2018, The Journal of Immunology.

Genome-Wide Posttranscriptional Dysregulation by MicroRNAs in Human Asthma as Revealed by Frac-seq

M. Niranjan, P. Howarth, R. Chambers, 2017, The Journal of Immunology.

Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3–like protein 1

P. Howarth, R. Djukanović, K. Izuhara, 2016, The Journal of allergy and clinical immunology.

Evaluation of a rapid lateral flow immunoassay for Staphylococcus aureus detection in respiratory samples.

Lea Ann Dailey, P. Howarth, L. Dailey, 2013, Diagnostic microbiology and infectious disease.

Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort

Ioannis Pandis, Charles Auffray, Thomas Sandström, 2015, European Respiratory Journal.

Detection of exacerbations in asthma based on electronic diary data: results from the 1-year prospective BIOAIR study

Eleni Tzortzaki, Peter J Sterk, Mina Gaga, 2013, Thorax.

Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial

Ian D Pavord, Peter Howarth, Stephanie Korn, 2012, The Lancet.

Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma.

P. Howarth, S. Holgate, D. Davies, 2005, Thorax.

Clinical assessment of speech correlates well with lung function during induced bronchoconstriction

P. Howarth, C. Grainge, J. Holloway, 2015, npj Primary Care Respiratory Medicine.

Potentially Pathogenic Airway Bacteria and Neutrophilic Inflammation in Treatment Resistant Severe Asthma

P. Howarth, G. Rogers, C. Grainge, 2014, PloS one.

Connectivity patterns between multiple allergen specific IgE antibodies and their association with severe asthma.

S. Filippi, P. Howarth, G. Roberts, 2020, The Journal of allergy and clinical immunology.

Mechanisms of allergy and clinical immunology Tissue factor – bearing exosome secretion from human mechanically stimulated bronchial epithelial cells in vitro and in vivo

J. Drazen, P. Howarth, D. Tschumperlin, 2012 .

TNF-α-mediated bronchial barrier disruption and regulation by src-family kinase activation.

P. Howarth, S. Holgate, D. Davies, 2013, The Journal of allergy and clinical immunology.

Pathways Activated during Human Asthma Exacerbation as Revealed by Gene Expression Patterns in Blood

Geoffrey L. Chupp, Andrew A. Hill, Andrew J. Wardlaw, 2011, PloS one.

Specific IgE against Staphylococcus aureus enterotoxins: an independent risk factor for asthma.

K. Van Steen, P. Howarth, J. Bousquet, 2012, The Journal of allergy and clinical immunology.

Exhaled volatile organic compounds in adult asthma: a systematic review

P. Howarth, J. Riley, C. Barber, 2019, European Respiratory Journal.

Clinical and transcriptomic features of persistent exacerbation‐prone severe asthma in U‐BIOPRED cohort

C. Auffray, P. Howarth, A. Bansal, 2022, Clinical and translational medicine.

Pathway discovery using transcriptomic profiles in adult‐onset severe asthma

Stelios Pavlidis, Charles Auffray, Bertrand De Meulder, 2017, The Journal of allergy and clinical immunology.

“T2-high” in severe asthma related to blood eosinophil, exhaled nitric oxide and serum periostin

C. Auffray, P. Howarth, Yike Guo, 2019, European Respiratory Journal.

Contribution of airway eosinophils in airway wall remodeling in asthma: Role of MMP‐10 and MET

C. Auffray, P. Howarth, Yike Guo, 2019, Allergy.

Variant LTC4 synthase allele modifies cysteinyl leukotriene synthesis in eosinophils and predicts clinical response to zafirlukast

I. Sayers, P. Howarth, S. Holgate, 2000, Thorax.

Effect of bronchoconstriction on airway remodeling in asthma.

P. Howarth, Susan J Wilson, S. Holgate, 2011, The New England journal of medicine.

Large-Scale Label-Free Quantitative Mapping of the Sputum Proteome.

C. Auffray, P. Howarth, James P R Schofield, 2018, Journal of proteome research.

Osteopontin is expressed and functional in human eosinophils

P. Howarth, D. Ribatti, D. Davies, 2010, Allergy.

Reliability of EP3OS symptom criteria and nasal endoscopy in the assessment of chronic rhinosinusitis – a GA2LEN study

D. Jarvis, P. Howarth, C. Bachert, 2011, Allergy.

Airway inflammation and atopic asthma: a comparative bronchoscopic investigation.

P. Howarth, R. Djukanović, S. Holgate, 1991, International archives of allergy and applied immunology.

Influence of albuterol, cromolyn sodium and ipratropium bromide on the airway and circulating mediator responses to allergen bronchial provocation in asthma.

P. Howarth, S. Holgate, T. Lee, 2015, The American review of respiratory disease.

Allergenic proteases cleave the chemokine CX3CL1 directly from the surface of airway epithelium and augment the effect of rhinovirus

P. Howarth, S. Holgate, D. Davies, 2017, Mucosal Immunology.

Synthetic responses in airway smooth muscle.

P. Howarth, R. Panettieri, A. Knox, 2004, The Journal of allergy and clinical immunology.

Invited Lecture: Activation of the Epithelial Mesenchymal Trophic Unit in the Pathogenesis of Asthma

P. Howarth, Susan J Wilson, S. Holgate, 2001, International Archives of Allergy and Immunology.

Effect of natural allergen exposure during the grass pollen season on airways inflammatory cells and asthma symptoms.

P. Howarth, R. Djukanović, S. Holgate, 1996, Thorax.

The effects of regular inhaled formoterol, budesonide, and placebo on mucosal inflammation and clinical indices in mild asthma.

P. Howarth, T. Sandström, R. Djukanović, 1999, American journal of respiratory and critical care medicine.

In vitro, in silico and in vivo study challenges the impact of bronchial thermoplasty on acute airway smooth muscle mass loss

P. Howarth, C. Brightling, S. Bicknell, 2018, European Respiratory Journal.

Temperature-controlled laminar airflow in severe asthma for exacerbation reduction (The LASER Trial): study protocol for a randomised controlled trial

P. Howarth, N. Rahman, R. Luengo-Fernandez, 2016, Trials.

Understanding the pathophysiology of severe asthma to generate new therapeutic opportunities.

P. Howarth, Susan J Wilson, S. Holgate, 2006, The Journal of allergy and clinical immunology.

Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines.

P. Howarth, R. Djukanović, S. Holgate, 1994, American journal of respiratory cell and molecular biology.

The soluble form of a disintegrin and metalloprotease 33 promotes angiogenesis: implications for airway remodeling in asthma.

David I. Wilson, P. Howarth, D. Ribatti, 2008, The Journal of allergy and clinical immunology.

Pharmacotherapy and airway remodelling in asthma?

P. Howarth, P. Beckett, 2003, Thorax.

Sensitization via healthy skin programs Th2 responses in individuals with atopic dermatitis.

P. Howarth, E. Healy, J. Holloway, 2013, The Journal of investigative dermatology.

Regulation of a disintegrin and metalloprotease-33 expression by transforming growth factor-β.

P. Howarth, S. Holgate, D. Davies, 2012, American journal of respiratory cell and molecular biology.

Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium

L. Wain, N. Shrine, C. Billington, 2020, JCI insight.

Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and airway epithelium in asthma

L. Wain, N. Shrine, C. Billington, 2018 .

Remodelling of the upper airways in allergic rhinitis: is it a feature of the disease?

P. Howarth, R. Salib, P. Howarth, 2003, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Control of exposure to mite allergen and allergen-impermeable bed covers for adults with asthma.

D. Strachan, A. Woodcock, P. Howarth, 2003, The New England journal of medicine.

Influence of interleukin-8 challenge in the nasal mucosa in atopic and nonatopic subjects.

P. Howarth, S. Holgate, J. Douglass, 1994, American journal of respiratory and critical care medicine.

Expression of c-erbB receptors and ligands in the bronchial epithelium of asthmatic subjects.

P. Howarth, S. Holgate, D. Davies, 2002, The Journal of allergy and clinical immunology.

Astemizole, a potent histamine H1-receptor antagonist: effect in allergic rhinoconjunctivitis, on antigen and histamine induced skin weal responses and relationship to serum levels.

P. Howarth, S. Holgate, M. Emanuel, 1984, British journal of clinical pharmacology.

Local genetic and environmental factors in asthma disease pathogenesis: chronicity and persistence mechanisms

P. Howarth, S. Holgate, D. Davies, 2007, European Respiratory Journal.

Identification of lipocalin and apolipoprotein A1 as biomarkers of chronic obstructive pulmonary disease.

P. Howarth, Dave Singh, B. Nicholas, 2010, American journal of respiratory and critical care medicine.

Increased levels of exhaled nitric oxide during nasal and oral breathing in subjects with seasonal rhinitis.

P. Howarth, U. Martin, K. Bryden, 1996, The Journal of allergy and clinical immunology.

Transforming Growth Factor-Beta Promotes Rhinovirus Replication in Bronchial Epithelial Cells by Suppressing the Innate Immune Response

P. Howarth, S. Holgate, D. Davies, 2012, PloS one.

Induction of the epidermal growth factor receptor and its ligands in nasal epithelium by ozone.

P. Howarth, S. Holgate, D. Davies, 2004, The Journal of allergy and clinical immunology.

Staphylococcus aureus enterotoxin‐specific IgE is associated with asthma in the general population: a GA2LEN study

D. Jarvis, C. Janson, P. Howarth, 2013, Allergy.

Airway expression of SARS-CoV-2 receptor, ACE2, and proteases, TMPRSS2 and furin, in severe asthma

P. Howarth, I. Adcock, K. Chung, 2020, medRxiv.

Altered Epithelial Gene Expression in Peripheral Airways of Severe Asthma

P. Howarth, D. Davies, A. Singhania, 2017, PloS one.

Repeated high‐dose inhalation allergen challenge in asthma

P. Howarth, C. Grainge, 2011, The clinical respiratory journal.

Airway Elastin is increased in severe asthma and relates to proximal wall area: histological and computed tomography findings from the U‐BIOPRED severe asthma study

P. Howarth, Susan J Wilson, J. Ward, 2020, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

ADAM33 expression in asthmatic airways and human embryonic lungs.

David I. Wilson, P. Howarth, Susan J Wilson, 2005, American journal of respiratory and critical care medicine.

A disintegrin and metalloprotease 33 expression in asthmatic airways and human embryonic lungs

David I. Wilson, P. Howarth, Susan J Wilson, 2005 .

Chemokine Receptor 4 Plays a Key Role in T Cell Recruitment into the Airways of Asthmatic Patients

P. Howarth, R. Djukanović, G. Seumois, 2010, The Journal of Immunology.

Mechanisms of airway epithelial damage: epithelial-mesenchymal interactions in the pathogenesis of asthma

P. Howarth, S. Holgate, D. Davies, 2003, European Respiratory Journal.

Case series reporting the effectiveness of mycophenolate mofetil in treatment-resistant asthma

P. Howarth, R. Kurukulaaratchy, C. Grainge, 2013, European Respiratory Journal.

Double-stranded RNA induces disproportionate expression of thymic stromal lymphopoietin versus interferon-β in bronchial epithelial cells from donors with asthma

P. Howarth, S. Holgate, D. Davies, 2010, Thorax.

Eosinophils in Health and Disease: A State-of-the-Art Review.

P. Howarth, P. Merkel, A. Wardlaw, 2021, Mayo Clinic proceedings.

Response to case report: Airway autoimmune responses in severe eosinophilic asthma following low-dose Mepolizumab therapy

P. Howarth, E. Bradford, I. Pouliquen, 2017, Allergy, Asthma & Clinical Immunology.

CYTOKINE PRODUCTION BY CELL CULTURES FROM BRONCHIAL SUBEPITHELIAL MYOFIBROBLASTS

P. Howarth, W. Roche, S. Zhang, 1996, The Journal of pathology.

Epigenetic mechanisms silence a disintegrin and metalloprotease 33 expression in bronchial epithelial cells.

P. Howarth, S. Holgate, D. Davies, 2008, The Journal of allergy and clinical immunology.

Salbutamol but not ipratropium abolishes leukotriene D4-induced gas exchange abnormalities in asthma

P. Howarth, F. Gómez, R. Rodríguez-Roisín, 2012, European Journal of Clinical Pharmacology.

How to design and evaluate randomized controlled trials in immunotherapy for allergic rhinitis: an ARIA‐GA2LEN statement

P. Howarth, H. Schünemann, J. Bousquet, 2011, Allergy.

Mast cell and eosinophil proteases in the chronic allergic inflammatory response

P. Howarth, S. Holgate, J. Warner, 1998 .

Sputum processing by mechanical dissociation: A rapid alternative to traditional sputum assessment approaches

P. Howarth, J. Ward, L. Lau, 2021, The clinical respiratory journal.

Severe eosinophilic asthma with nasal polyposis: A phenotype for improved sino-nasal and asthma outcomes with mepolizumab therapy.

F. Albers, P. Howarth, C. Bachert, 2020, The Journal of allergy and clinical immunology.

Fungal sensitization and its relationship to mepolizumab response in patients with severe eosinophilic asthma

F. Albers, E. Israel, P. Howarth, 2020, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Asthma Exacerbations Associated with Lung Function Decline in Patients with Severe Eosinophilic Asthma.

H. Ortega, F. Albers, S. Yancey, 2018, The journal of allergy and clinical immunology. In practice.

Airway Inflammation in Atopic Patients

P. Howarth, Susan J Wilson, S. Bhimrao, 2011, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

Altered protein tyrosine phosphorylation in asthmatic bronchial epithelium

P. Howarth, T. Sandström, S. Holgate, 2005, European Respiratory Journal.

Asthmatic bronchial epithelium is more susceptible to oxidant-induced apoptosis.

P. Howarth, Susan J Wilson, R. Djukanović, 2002, American journal of respiratory cell and molecular biology.

Inhaled beclomethasone dipropionate downregulates airway lymphocyte activation in atopic asthma.

P. Howarth, R. Djukanović, S. Holgate, 1994, American journal of respiratory and critical care medicine.

Intercellular adhesion molecule-1 (ICAM-1) and endothelial leucocyte adhesion molecule-1 (ELAM-1) expression in the bronchial mucosa of normal and asthmatic subjects.

P. Howarth, R. Djukanović, S. Montefort, 1992, The European respiratory journal.

Quantitation of mast cells and eosinophils in the bronchial mucosa of symptomatic atopic asthmatics and healthy control subjects using immunohistochemistry.

P. Howarth, R. Djukanović, S. Holgate, 1991, The American review of respiratory disease.

Exhaled nitric oxide; relationship to clinicophysiological markers of asthma severity.

P. Howarth, M. Al-Ali, C. Eames, 1998, Respiratory medicine.

Increased expression of inducible nitric oxide synthase and cyclo-oxygenase-2 in the airway epithelium of asthmatic subjects and regulation by corticosteroid treatment.

P. Howarth, S. Holgate, J. Polak, 2001, Thorax.

Expression of CD44 and integrins in bronchial mucosa of normal and mildly asthmatic subjects.

P. Howarth, R. Djukanović, S. Holgate, 1996, The European respiratory journal.

CaMKII Is Essential for the Proasthmatic Effects of Oxidation

Mark E. Anderson, P. Howarth, D. Meyerholz, 2013, Science Translational Medicine.

The relationship between mast cell-mediator release and bronchial reactivity in allergic asthma.

P. Howarth, S. Holgate, A. Kay, 1987, The Journal of allergy and clinical immunology.

Immunohistochemistry on resin sections: a comparison of resin embedding techniques for small mucosal biopsies.

P. Howarth, K. Britten, W. Roche, 1993, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

Microbes and asthma: Opportunities for intervention.

P. Howarth, R. Maizels, M. Ege, 2016, The Journal of allergy and clinical immunology.

T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma.

P. Howarth, N. Krug, R. Djukanović, 1996, American journal of respiratory cell and molecular biology.

Cellular and mediator responses twenty-four hours after local endobronchial allergen challenge of asthmatic airways.

P. Howarth, S. Holgate, A. Frew, 1996, The Journal of allergy and clinical immunology.

Asthma and anaphylaxis: a relevant model for chronic disease? An historical analysis of directions in asthma research

P. Howarth, M. Emanuel, P. Howarth, 1995, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Mast Cells, Cytokines and Asthma

P. Howarth, A. Redington, 1994 .

Safety aspects of local endobronchial allergen challenge in asthmatic patients.

P. Howarth, N. Krug, S. Holgate, 1996, American journal of respiratory and critical care medicine.

The airway inflammatory response in allergic asthma and its relationship to clinical disease

P. Howarth, 1995, Allergy.

Validation of endobronchial biopsy specimens for nerve quantitation by computer‐assisted image analysis

P. Howarth, S. Holgate, C. Doré, 2000, The Journal of pathology.

Exhaled nitric oxide levels in exacerbations of asthma, chronic obstructive pulmonary disease and pneumonia.

P. Howarth, M. Al-Ali, 2001, Saudi medical journal.

Eridothelin immunoreactivity of airway epithelium in asthmatic patients

H. Counihan, P. Howarth, R. Djukanović, 1991, The Lancet.

Neuropeptide-containing nerves in endobronchial biopsies from asthmatic and nonasthmatic subjects.

P. Howarth, R. Djukanović, S. Holgate, 1995, American journal of respiratory cell and molecular biology.

Mechanisms and mediators of nasal symptoms in non‐allergic rhinitis

P. Howarth, R. Salib, S. Nair, 2008, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Inflammatory and T-cell profile of asthmatic airways 6 hours after local allergen provocation.

P. Howarth, S. Holgate, S. Montefort, 1996, American journal of respiratory and critical care medicine.

Composite type-2 biomarker strategy versus a symptom–risk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre, single-blind, parallel group, randomised controlled trial

I. Pavord, A. Woodcock, P. Howarth, 2020, The Lancet. Respiratory medicine.

Mechanical Strain Causes Adaptive Change in Bronchial Fibroblasts Enhancing Profibrotic and Inflammatory Responses

P. Howarth, F. Bucchieri, S. Holgate, 2016, PloS one.

Enhanced oxidative stress in smoking and ex-smoking severe asthma in the U-BIOPRED cohort

C. Auffray, P. Howarth, A. Bansal, 2018, PloS one.

Urinary metabotype of severe asthma evidences decreased carnitine metabolism independent of oral corticosteroid treatment in the U-BIOPRED study

P. Howarth, D. Shaw, P. Bakke, 2021, European Respiratory Journal.

Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK)

I. Pavord, A. Woodcock, Dirk E. Smith, 2015, Thorax.

The effect of long-acting beta2-agonists on airway inflammation in asthmatic patients.

P. Howarth, R. Dahl, P. Beckett, 2000, Respiratory medicine.

S30 CEACAM5 (CD66e) mucosal immunoreactivity and its relationship to asthma

P. Howarth, J. Ward, S. Wilson, 2018, Mucosal and microbial drivers of asthma.

Neutrophil influx and interleukin-8 release after segmental allergen or saline challenge in asthmatics.

P. Howarth, S. Holgate, D. Davies, 1995, International archives of allergy and immunology.

Mucosal inflammation and asthma.

P. Howarth, R. Djukanović, S. Holgate, 1994, American journal of respiratory and critical care medicine.

Leukocyte recruitment after local endobronchial allergen challenge in asthma. Relationship to procedure and to airway interleukin-8 release.

P. Howarth, S. Holgate, D. Davies, 1996, American journal of respiratory and critical care medicine.

Bronchial biopsy evidence for leukocyte infiltration and upregulation of leukocyte-endothelial cell adhesion molecules 6 hours after local allergen challenge of sensitized asthmatic airways.

P. Howarth, S. Holgate, S. Montefort, 1994, The Journal of clinical investigation.

Early changes in T lymphocytes recovered by bronchoalveolar lavage after local allergen challenge of asthmatic airways.

P. Howarth, S. Holgate, M. Carroll, 1992, The American review of respiratory disease.

Bronchial mucosal manifestations of atopy: a comparison of markers of inflammation between atopic asthmatics, atopic nonasthmatics and healthy controls.

P. Howarth, R. Djukanović, S. Holgate, 1992, The European respiratory journal.

Lymphocyte activation in bronchoalveolar lavage and peripheral blood in atopic asthma.

P. Howarth, R. Djukanović, S. Holgate, 1992, The American review of respiratory disease.

Nasal mucosal expression of the leukotriene and prostanoid pathways in seasonal and perennial allergic rhinitis

P. Howarth, J. Penrose, A. Sampson, 2009, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Allergic rhinitis: not purely a histamine‐related disease

P. Howarth, 2000, Allergy.

Leukotrienes in rhinitis.

P. Howarth, 2000, American journal of respiratory and critical care medicine.

The role of leukotrienes in rhinitis

P. Howarth, 1998 .

Mediators of nasal blockage in allergic rbtis

P. Howarth, 1997 .

Kinins and rhinitis

P. Howarth, S. Holgate, R. Polosa, 1992, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

What's new about hay fever?

P. Howarth, S. Holgate, 1985, British medical journal.

Allergic rhinitis: past, present and the future.

P. Howarth, R. Salib, A. Drake-Lee, 2003, Clinical otolaryngology and allied sciences.

Pathology of rhinitis and bronchial asthma

P. Howarth, R. Djukanović, S. Wilson, 1996, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Prostaglandin D2-induced bronchoconstriction is mediated only in part by the thromboxane prostanoid receptor.

P. Howarth, S. Johnston, N. Freezer, 1995, The European respiratory journal.

The mast cell as a primary effector cell in the pathogenesis of asthma.

P. Howarth, S. Holgate, R. Agius, 1986, The Journal of allergy and clinical immunology.

Pathophysiology of asthma

P. Howarth, S. Montefort, A. Redington, 1993, Allergy.

Mechanisms of airways inflammation which may be amenable to prophylaxis.

P. Howarth, R. Djukanović, S. Holgate, 1993, Agents and actions. Supplements.

Histamine and asthma: an appraisal based on specific H1‐receptor antagonism

P. Howarth, P. Howarth, 1990, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Evaluation of sputum eosinophil count as a predictor of treatment response to mepolizumab

I. Pavord, S. Yancey, P. Howarth, 2022, ERJ Open Research.

Inflammatory mediators in naturally occurring rhinitis

P. Howarth, L. Lau, S. Wilson, 1998, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Comparative nasal effects of bradykinin and histamine: influence on nasal airways resistance and plasma protein exudation.

P. Howarth, S. Holgate, R. Polosa, 1993, Thorax.

The temporal relationship between the neural and vascular actions of kallidin within the nose

P. Howarth, S. Holgate, R. Polosa, 1993, Mediators of inflammation.

The effect of inhaled allergen on circulating basophils in atopic asthma.

P. Howarth, R. Djukanović, S. Holgate, 1992, The Journal of allergy and clinical immunology.

Mediators and allergic rhinitis

P. Howarth, I. Feather, K. Rajakulasingam, 1991, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Allergic rhinitis: a rational choice of treatment.

P. Howarth, Peter H. Howarth, Peter H. Howarth, 1989, Respiratory medicine.

A disintegrin and metalloprotease (ADAM) 33 protein in patients with pulmonary sarcoidosis

Mark G. Jones, P. Howarth, D. Davies, 2012, Respirology.

Paradoxical bronchoconstriction with nebulized albuterol but not with terbutaline.

P. Howarth, J. Finnerty, 1993, The American review of respiratory disease.

Methods of assessing LTRA efficacy in humans

P. Howarth, 2001 .

The role of the airway epithelium and its interaction with environmental factors in asthma pathogenesis.

P. Howarth, G. Roberts, S. Holgate, 2009, Proceedings of the American Thoracic Society.

The safety aspects of fiberoptic bronchoscopy, bronchoalveolar lavage, and endobronchial biopsy in asthma.

P. Howarth, R. Djukanović, S. Holgate, 1991, The American review of respiratory disease.

New insights into airway inflammation by endobronchial biopsy.

P. Howarth, S. Holgate, J. Wilson, 1992, The American review of respiratory disease.

Relationship between mediator release from human lung mast cells in vitro and in vivo.

P. Howarth, S. Durham, S. Holgate, 1985, International archives of allergy and applied immunology.

What we should learn from the London Olympics.

D. M. Thomas, P. Howarth, H. Schünemann, 2013, Current opinion in allergy and clinical immunology.

Double-blind, placebo-controlled study comparing the efficacy and safety of fexofenadine hydrochloride (120 and 180 mg once daily) and cetirizine in seasonal allergic rhinitis.

P. Howarth, J. Bousquet, L. Roi, 1999, The Journal of allergy and clinical immunology.

Heterogeneity of human mast cells based on cytokine content.

P. Howarth, S. Holgate, Y. Okayama, 1995, Journal of immunology.

The need for a pathological classification of asthma.

P. Howarth, R. Djukanović, S. Holgate, 1991, The European respiratory journal. Supplement.

Eosinophils and rhinitis

P. Howarth, 2005 .

Endothelin in bronchoalveolar lavage fluid and its relation to airflow obstruction in asthma.

P. Howarth, S. Holgate, J. Polak, 1995, American Journal of Respiratory and Critical Care Medicine.

The antihistamines of the nineties

P. Howarth, M. Janssens, 1993, Clinical reviews in allergy.

Proof of concept pilot study: prevalence of grass virus infection and the potential for effects on the allergenic potency of pollen

P. Howarth, J. Cooper, L. Lau, 2009, Environmental health : a global access science source.

Circulating adhesion molecules in asthma.

P. Howarth, P. Kapahi, S. Holgate, 1994, American journal of respiratory and critical care medicine.

Comment on: Pairwise indirect treatment comparison of dupilumab versus other biologics in patients with uncontrolled persistent asthma [Respir Med 2020].

P. Howarth, D. Bratton, O. Keene, 2020, Respiratory Medicine.

Airway remodelling in asthma and novel therapy.

P. Howarth, S. Holgate, W. Manuyakorn, 2013, Asian Pacific journal of allergy and immunology.

Interleukin 4 is localized to and released by human mast cells

P. Howarth, C. Heusser, Y. Okayama, 1992, The Journal of experimental medicine.

Basic fibroblast growth factor in asthma: measurement in bronchoalveolar lavage fluid basally and following allergen challenge.

P. Howarth, R. Djukanović, S. Holgate, 2001, The Journal of allergy and clinical immunology.

Increased Expression of p22phox Mediates Airway Hyperresponsiveness in an Experimental Model of Asthma.

P. Howarth, H. Haitchi, A. Olschewski, 2017, Antioxidants & redox signaling.

S114 Adaptive and Innate-Like T Cell Phenotypes in Asthma in Relationship to Compartment and Severity

P. Howarth, R. Djukanović, H. Virgin, 2012, Thorax.

FIBROBLASTS AND THE EXTRACELLULAR MATRIX IN ASTHMA

P. Howarth, S. Holgate, P. Sime, 1998 .

New topics in bradykinin research

P. Howarth, J. Lötvall, G. Kojda, 2011, Allergy.

Barrier Disrupting Effects of Alternaria Alternata Extract on Bronchial Epithelium from Asthmatic Donors

P. Howarth, S. Holgate, D. Davies, 2013, PloS one.

Urinary Leukotriene E4 and Prostaglandin D2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation. A Clinical Observational Study

P. Howarth, D. Shaw, P. Bakke, 2020, American journal of respiratory and critical care medicine.

Comparative nasal effects of bradykinin, kallidin and [Des‐Arg9]‐bradykinin in atopic rhinitic and normal volunteers.

P. Howarth, S. Holgate, R. Polosa, 1991, The Journal of physiology.

360 Effects of ozone on the nasal mucosa

P. Howarth, D. Dokic, 2000 .

Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma

P. Howarth, G. Roberts, A. Bansal, 2020, Respiratory Research.

Characterization of Bacterial Community Diversity in Chronic Rhinosinusitis Infections Using Novel Culture-independent Techniques

P. Howarth, G. Rogers, P. Harries, 2011, American journal of rhinology & allergy.

Effect of systemic beta-agonist therapy on IgE production in allergic subjects in vivo.

P. Howarth, J. Corne, C. Linaker, 1998, The Journal of allergy and clinical immunology.

Small airways and asthma. An important therapeutic target?

P. Howarth, 1998, American journal of respiratory and critical care medicine.

Airway effects of local challenge with hypertonic saline in exercise-induced asthma.

P. Howarth, S. Holgate, S. Montefort, 1994, American journal of respiratory and critical care medicine.

EXERCISE, ASTHMA, AND MAST CELLS

P. Howarth, S. Holgate, 1983, The Lancet.

Nasal mucosal immunoexpression of the mast cell chemoattractants TGF-beta, eotaxin, and stem cell factor and their receptors in allergic rhinitis.

P. Howarth, Susan J Wilson, Sanjiv Kumar, 2004, The Journal of allergy and clinical immunology.

Epithelially derived endothelin and nitric oxide in asthma.

P. Howarth, S. Holgate, J. Polak, 1995, International archives of allergy and immunology.

The relation of airway obstruction to asthma, chronic rhinosinusitis and age: results from a population survey of adults

D. Jarvis, C. Janson, P. Howarth, 2014, Allergy.

Urinary glycosaminoglycan levels are increased in acute severe asthma--a role for eosinophil-derived gelatinase B?

P. Howarth, S. Holgate, J. Shute, 1997, International archives of allergy and immunology.

Effects of short-term exposure to 0.2 ppm ozone on biomarkers of inflammation in sputum, exhaled nitric oxide, and lung function in subjects with mild atopic asthma.

P. Howarth, S. Holgate, E. Newson, 2000, Journal of occupational and environmental medicine.

Mucosal nerves in endobronchial biopsies in asthma and non-asthma.

P. Howarth, R. Djukanović, S. Holgate, 1991, International archives of allergy and applied immunology.

Distinct pathways underlying neutrophilic inflammation in smoking-associated severe asthma in U-BIOPRED

C. Auffray, P. Howarth, J. Corfield, 2017 .

IL-1α mediates cellular cross-talk in the airway epithelial mesenchymal trophic unit

P. Howarth, D. Davies, C. Grainge, 2016, Tissue barriers.

Reply.

P. Howarth, C. Bachert, Ana Sousa, 2020, The Journal of allergy and clinical immunology.

The allergen specificity of the late asthmatic reaction

P. Howarth, C. Grainge, L. Lau, 2010, Allergy.

Epithelial expression and release of FGF-2 from heparan sulphate binding sites in bronchial tissue in asthma

P. Howarth, A. Redington, W. McConnell, 2004, Thorax.

Persistent airway T-lymphocyte activation in chronic corticosteroid-treated symptomatic asthma.

P. Howarth, R. Djukanović, S. Holgate, 2000, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

Cross refractoriness between bradykinin and hypertonic saline challenges in asthma.

P. Howarth, S. Holgate, H. Makker, 1995, The Journal of allergy and clinical immunology.

Why particle size should affect clinical response to inhaled therapy.

P. Howarth, Peter H. Howarth, 2001, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

The T cell and the airway's fibrotic response in asthma.

P. Howarth, R. Djukanović, S. Holgate, 1993, Chest.

Respiratory hypersensitivity reactions to NSAIDs in Europe: the global allergy and asthma network (GA2LEN) survey

D. Jarvis, C. Janson, P. Howarth, 2016, Allergy.

Staphylococci and staphylococcal superantigens in asthma and rhinitis: a systematic review and meta‐analysis

P. Howarth, C. Pastacaldi, P. Lewis, 2011, Allergy.

135 The effect of inhaled beclomethasone dipropionate (BDP) on inflammatory cells in the asthmatic airways

P. Howarth, R. Djukanović, S. Holgate, 1991 .

The effect of BAY u 3405, a thromboxane receptor antagonist, on prostaglandin D2-induced nasal blockage.

P. Howarth, S. Johnston, J. Harrison, 1993, The Journal of allergy and clinical immunology.

Genome-wide association study to identify genetic determinants of severe asthma

L. Wain, N. Shrine, I. Sayers, 2011, Thorax.

Airway remodelling rather than cellular infiltration characterizes both type2 cytokine biomarker‐high and ‐low severe asthma

I. Pavord, P. Howarth, F. Symon, 2022, Allergy.

Asthmatic Patients Cell Recruitment into the Airways of Chemokine Receptor 4 Plays a Key Role in T

P. Howarth, R. Djukanović, G. Seumois, 2010 .

Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study

L. Wain, N. Shrine, C. Billington, 2019, The Lancet. Respiratory medicine.

The effect of acupuncture on nonallergic rhinitis: a controlled pilot study.

P. Howarth, G. Lewith, A. Davies, 1998, Alternative therapies in health and medicine.

Factors determining bradykinin bronchial responsiveness and refractoriness in asthma.

P. Howarth, S. Holgate, M. Church, 1993, The Journal of allergy and clinical immunology.

Effects of anti-eotaxin monoclonal antibody CAT-213 on allergen-induced rhinitis

P. Howarth, G. Scadding, R. Salib, 2003 .

Control of salicylate intolerance with fish oils

P. Howarth, E. Healy, P. Friedmann, 2008, The British journal of dermatology.

Allergic rhinitis: an increasing clinical problem

P. Howarth, K. Holmberg, P. Howarth, 1995, Allergy.

Nontypeable Haemophilus influenzae infection of pulmonary macrophages drives neutrophilic inflammation in severe asthma

Ashley I Heinson, P. Howarth, R. Kurukulaaratchy, 2022, Allergy.

The development of guidelines for allergic rhinitis

P. Howarth, 2001 .

144 Airway hyperreactivity and mediator release in clinical models of asthma

P. Howarth, S. Durham, S. Holgate, 1985 .

The anti-inflammatory response of anti-eotaxin monoclonal antibody CAT-213 on nasal allergen-induced cell infiltration and activation

P. Howarth, G. Scadding, L. Lau, 2003 .

The nasal mast cell and rhinitis

P. Howarth, L. Lau, S. Wilson, 1991, Clinical and Experimental Allergy.

The influence of terfenadine and ipratropium bromide alone and in combination on bradykinin‐induced nasal symptoms and plasma protein leakage

P. Howarth, S. Holgate, R. Polosa, 1992, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Allergic Rhinitis and its Impact on Asthma (ARIA): In collaboration with the World Health Organization

J. Kemp, P. Howarth, J. Bousquet, 2002 .

The cellular basis for allergic rhinitis

P. Howarth, P. Howarth, 1995, Allergy.

ACE2, TMPRSS2, and furin gene expression in the airways of people with asthma—implications for COVID-19

P. Howarth, S. Wenzel, P. Bradding, 2020, Journal of Allergy and Clinical Immunology.

A comparison of the anti‐inflammatory properties of intranasal corticosteroids and antihistamines in allergic rhinitis

P. Howarth, P. Howarth, 2000, Allergy.

Astemizole and other H1-antihistaminic drug treatment of asthma.

P. Howarth, S. Holgate, M. Emanuel, 1985, The Journal of allergy and clinical immunology.

Asthma, rhinitis, other respiratory diseases Double-blind, placebo-controlled study comparing the efficacy and safety of fexofenadine hydrochloride (120 and 180 mg once daily) and cetirizine in seasonal allergic rhinitis

P. Howarth, J. Bousquet, L. Roi, 1999 .

The time course of action of three differing doses of noberastine, a novel H1-receptor antagonist, on histamine-induced skin wheals and the relationship to plasma drug concentrations in normal human volunteers.

P. Howarth, R. Wood-Baker, M. Emanuel, 1993, British journal of clinical pharmacology.

Comparative trial of two non-sedative H1 antihistamines, terfenadine and astemizole, for hay fever.

P. Howarth, S. Holgate, 1984, Thorax.

Cyclosporin A treatment and airways inflammation in corticosteroid‐dependent asthma

P. Howarth, S. Holgate, F. Hardinge, 1998, Allergy.

Nasal effects of bradykinin and capsaicin: influence on plasma protein leakage and role of sensory neurons.

P. Howarth, S. Holgate, R. Polosa, 1992, Journal of applied physiology.

Induction of nitric oxide synthase in asthma

P. Howarth, J. Bousquet, S. Holgate, 1993, The Lancet.

THE CONCEPT OF THE THERAPEUTIC WINDOW IN THE CHOICE OF H1-RECEPTOR ANTAGONIST *

P. Howarth, 2004 .

Role of Mast Cells and Basophils in Asthma (Part 1 of 2)

P. Howarth, S. Holgate, R. Polosa, 1995 .

Role of mast cells and basophils in asthma.

P. Howarth, S. Holgate, R. Polosa, 1995, Chemical Immunology.

The Influence of Non-Specific Airway Reactivity on the Immediate Bronchoconstrictor Response to Exercise and Antigen in Asthma

P. Howarth, S. Holgate, B. Sihra, 1984 .

Comparison of whole-blood eosinophil counts in extrinsic asthmatics with acute and chronic asthma

P. Howarth, 1982, British medical journal.

Small airway inflammation and asthma.

P. Howarth, 1998, International journal of clinical practice. Supplement.

Clinical nasal decongestant activity with oral antihistamines

P. Howarth, P. Howarth, 2002 .

51 The effect of Seldane-D, terfenadine and pseudoephedrine on the nasal response to allergen

P. Howarth, I. Feather, H. Brewster, 1991 .

50 The influence of cetirizine on symptom generation and nasal eosinophilia in seasonal allergic rhinitis

P. Howarth, S. Wilson, H. Brewster, 1991 .

Susceptibility to influenza virus infection of bronchial biopsies in asthma.

P. Howarth, B. Nicholas, I. Adcock, 2017, The Journal of allergy and clinical immunology.

Analysis of allergen immunotherapy studies shows increased clinical efficacy in highly symptomatic patients

P. Howarth, P. Devillier, H. Malling, 2012, Allergy.

Airway Surfactant Protein D Deficiency in Adults With Severe Asthma.

P. Howarth, C. Grainge, L. Lau, 2016, Chest.

Measurement of Exhaled Volatile Organic Compounds as a Biomarker for Personalised Medicine: Assessment of Short-Term Repeatability in Severe Asthma

P. Howarth, R. Kurukulaaratchy, F. Rezwan, 2022, Journal of personalized medicine.

Mepolizumab (anti-IL-5) reduces exacerbations in patients with refractory eosinophilic asthma

I. Pavord, E. Bleecker, H. Ortega, 2012 .

Genetic and environmental influences on airway inflammation in asthma.

P. Howarth, R. Djukanović, S. Holgate, 1995, International archives of allergy and immunology.

Assessment of the long‐term safety of mepolizumab and durability of clinical response in patients with severe eosinophilic asthma

H. Ortega, F. Albers, S. Yancey, 2019, The Journal of allergy and clinical immunology.

248 Astemizole, a H1-antagonist, in allergic asthma

P. Howarth, S. Holgate, 1985 .

CD48 on blood leukocytes and in serum of asthma patients varies with severity

P. Howarth, S. Holgate, F. Levi-Schaffer, 2017, Allergy.

Characteristics of the frequent exacerbator in U-BIOPRED adult severe asthma cohort

P. Howarth, G. Roberts, A. Bansal, 2015 .

House‐dust mite allergen Der p 1: amount or concentration?

P. Howarth, I. J. M. Doull, J. Bright, 1997, Allergy.

Cellular and biochemical events in the pathogenesis of asthma.

P. Howarth, S. Holgate, R. Agius, 1986, European journal of respiratory diseases. Supplement.

Preface to outcome measures in allergic rhinitis.

P. Howarth, A. Togias, P. Silkoff, 2005, The Journal of allergy and clinical immunology.

Inhibition of Pim1 kinase reduces viral replication in primary bronchial epithelial cells

P. Howarth, M. Nawijn, D. Davies, 2015, European Respiratory Journal.

Transforming growth factor-beta 1 in asthma. Measurement in bronchoalveolar lavage fluid.

P. Howarth, R. Djukanović, S. Holgate, 1997, American journal of respiratory and critical care medicine.

Expression of c-erbB receptors and ligands in human nasal epithelium.

P. Howarth, S. Holgate, D. Davies, 2000, The Journal of allergy and clinical immunology.

Severe acute respiratory syndrome coronavirus 2 infection in those on mepolizumab therapy

P. Howarth, L. Pini, A. Azim, 2021, Annals of Allergy, Asthma & Immunology.

SARS-CoV2 infection in those on Mepolizumab therapy

P. Howarth, L. Pini, A. Azim, 2021, Annals of Allergy, Asthma & Immunology.

Determinants of asthma severity.

P. Howarth, R. Djukanović, S. Holgate, 1995, International archives of allergy and immunology.

Effect of thromboxane A2-receptor antagonist on bradykinin-induced bronchoconstriction in asthma.

P. Howarth, S. Johnston, S. Holgate, 1996, Journal of applied physiology.

The long-acting beta2-agonist salmeterol xinafoate: effects on airway inflammation in asthma.

P. Howarth, S. Holgate, P. Bradding, 1999, The European respiratory journal.

Quantitation of mast cells and eosinophils in the bronchial mucosa of symptomatic atopic asthmatics and healthy control subjects using immunohistochemistry.

P. Howarth, R. Djukanović, S. Holgate, 1991, The American review of respiratory disease.

Real‐world Omalizumab and Mepolizumab treated difficult asthma phenotypes and their clinical outcomes

P. Howarth, R. Kurukulaaratchy, S. H. Arshad, 2021, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

CD 48 on blood leukocytes and in serum of asthma patients varies with severity Short title CD 48 expression varies according to asthma severity Authors

P. Howarth, S. Holgate, F. Levi-Schaffer, 2016 .

human embryonic lungs.

David I. Wilson, P. Howarth, Susan J Wilson, 2005 .

285 Bronchial mucosal intercellular adhesion molecule-1 [ICAM-1] and endothelial leukocyte adhesion molecule-1 [ELAM-1] expression in normals and asthmatics

P. Howarth, S. Holgate, S. Montefort, 1991 .

Response to mepolizumab treatment is sustained across 4-weekly dosing periods

I. Pavord, E. Bleecker, F. Albers, 2020, ERJ Open Research.

Leukotriene C4 Synthase Gene Polymorphism in Severe Asthma

I. Sayers, P. Howarth, S. Holgate, 2001 .

MUCOSAL INFLAMMATION AND ALLERGIC RHINITIS

P. Howarth, 1999 .

The roles of eosinophils and interleukin‐5 in the pathophysiology of chronic rhinosinusitis with nasal polyps

S. Yancey, P. Howarth, C. Bachert, 2022, International forum of allergy & rhinology.

The influence of 5-lipoxygenase inhibition in allergic rhinitis.

P. Howarth, L. Lau, K. Harrison, 1995, International archives of allergy and immunology.

The effect of local hyperthermia on allergen-induced nasal congestion and mediator release.

P. Howarth, S. Johnston, S. Holgate, 1993, The Journal of allergy and clinical immunology.

Airway wall remodelling in asthma.

P. Howarth, A. Redington, 1997, Thorax.

Resistin‐like molecule‐β is induced following bronchoconstriction of asthmatic airways

P. Howarth, J. Ward, D. Davies, 2012, Respirology.

The effect of treatment with oral corticosteroids on asthma symptoms and airway inflammation.

P. Howarth, R. Djukanović, S. Holgate, 1997, American journal of respiratory and critical care medicine.

Increased expression of p21(waf) cyclin-dependent kinase inhibitor in asthmatic bronchial epithelium.

P. Howarth, Susan J Wilson, R. Djukanović, 2003, American journal of respiratory cell and molecular biology.

Asthmatic and normal respiratory epithelial cells respond differently to mechanical apical stress.

P. Howarth, D. Davies, L. Lau, 2014, American journal of respiratory and critical care medicine.

Soluble tumor necrosis factor alpha (TNF-alpha) receptor (Enbrel) as an effective therapeutic strategy in chronic severe asthma*

P. Howarth, S. Holgate, D. Davies, 2003 .

Salbutamol but not ipratropium abolishes leukotriene D4-induced gas exchange abnormalities in asthma

P. Howarth, F. Gómez, R. Rodríguez-Roisín, 2012, European Journal of Clinical Pharmacology.

The release and role of inflammatory mediators in asthma.

P. Howarth, S. Holgate, C. Robinson, 1985, Clinical immunology reviews.

Common airborne fungi induce species-specific effects on upper airway inflammatory and remodelling responses.

P. Howarth, P. Harries, L. Lau, 2016, Rhinology.

Mediators of nasal blockage in allergic rhinitis.

P. Howarth, 1997, Allergy.

Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation.

P. Howarth, S. Holgate, C. Heusser, 1993, Journal of immunology.

Defective epithelial barrier function in asthma.

P. Howarth, R. Djukanović, S. Holgate, 2011, The Journal of allergy and clinical immunology.

Multitissue Transcriptomics Delineates the Diversity of Airway T Cell Functions in Asthma

P. Howarth, R. Djukanović, A. Singhania, 2017, American journal of respiratory cell and molecular biology.

Airway and peripheral uPAR is elevated in asthma, and identifies a severe, non-atopic subset of patients

D. Postma, I. Sayers, G. Koppelman, 2016 .

Choosing the right pharmacological therapy in allergic rhinitis

P. Howarth, R. Salib, 2004 .

The influence of terfenadine and pseudo-ephedrine alone and in combination on allergen-induced rhinitis.

P. Howarth, S. Smith, K. Harrison, 1993, International archives of allergy and immunology.

Allergic Rhinitis and its Impact on Asthma (ARIA): achievements in 10 years and future needs.

Todor A Popov, D. Postma, A. Sheikh, 2012, The Journal of allergy and clinical immunology.

Sputum microbiome profiles identify severe asthma phenotypes of relative stability at 12-18 months.

P. Howarth, S. Dahlén, J. Riley, 2020, The Journal of allergy and clinical immunology.

Real-life effectiveness of mepolizumab in severe asthma: a systematic literature review

P. Howarth, G. Canonica, R. Alfonso-Cristancho, 2021, The Journal of asthma : official journal of the Association for the Care of Asthma.

Effects of Ischaemic Heart Disease, Crohn’s Disease and Antimicrobial Therapy on the Pharmacokinetics of Sulphinpyrazone

P. Howarth, A. Renwick, C. George, 1986, Clinical pharmacokinetics.

The control of allergens of dust mites and domestic pets: a position paper

P. Howarth, A. Woodcock, J. Warner, 1992, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

The Clinical Implications of Aspergillus Fumigatus Sensitization in Difficult-To-Treat Asthma Patients.

P. Howarth, H. Haitchi, R. Kurukulaaratchy, 2021, The journal of allergy and clinical immunology. In practice.

Involvement of the epidermal growth factor receptor in epithelial repair in asthma

P. Howarth, S. Holgate, D. Davies, 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Consensus statement * on the treatment of allergic rhinitis

J Bousquet, W J Fokkens, P. Howarth, 2000, Allergy.

Is diet partly responsible for differences in COVID-19 death rates between and within countries?

Ana C. Coelho, Todor A Popov, I. Pavord, 2020, Clinical and Translational Allergy.

Innate and adaptive T cells in asthmatic patients: Relationship to severity and disease mechanisms

Borislav D. Dimitrov, Tanya Petrossian, Stephan D. Gadola, 2015, The Journal of allergy and clinical immunology.

Nitric oxide and the respiratory system in health and disease.

P. Howarth, M. Al-Ali, Musa K. Al-Ali, 1998, Respiratory medicine.

Transcriptomic gene signatures associated with persistent airflow limitation in patients with severe asthma

C. Auffray, P. Howarth, A. Bansal, 2017, European Respiratory Journal.

Lipid phenotyping of lung epithelial lining fluid in healthy human volunteers

C. Auffray, K. Bønnelykke, H. Bisgaard, 2018, Metabolomics.

Phenotypic and functional translation of IL33 genetics in asthma.

L. Wain, N. Shrine, C. Billington, 2020, The Journal of allergy and clinical immunology.

Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life

David I. Wilson, Jeffrey A. Whitsett, Stephen T. Holgate, 2016, JCI insight.

MicroRNAs and respiratory diseases

P. Howarth, H. Rupani, T. Sanchez-Elsner, 2012, European Respiratory Journal.

A MicroRNA Network Dysregulated in Asthma Controls IL-6 Production in Bronchial Epithelial Cells

P. Howarth, S. Holgate, D. Davies, 2014, PloS one.

MACVIA‐ARIA Sentinel NetworK for allergic rhinitis (MASK‐rhinitis): the new generation guideline implementation

F. Rodenas, G. Joos, R. Bourret, 2015, Allergy.

Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)

D. Postma, I. Pavord, A. Sheikh, 2016, Clinical and Translational Allergy.

Severe Chronic Allergic (and Related) Diseases: A Uniform Approach – A MeDALL – GA2LEN – ARIA Position Paper

D. Postma, C. Auffray, A. Sheikh, 2012, International Archives of Allergy and Immunology.

Objective monitoring of nasal patency and nasal physiology in rhinitis

Alkis Togias, P. Howarth, A. Togias, 2005, Journal of Allergy and Clinical Immunology.

Co‐localization of immunoreactive transforming growth factor‐beta1 and decorin in bronchial biopsies from asthmatic and normal subjects

P. Howarth, S. Holgate, A. Redington, 1998, The Journal of pathology.

Safety and Tolerability Profiles of Intranasal Antihistamines and Intranasal Corticosteroids in the Treatment of Allergic Rhinitis

P. Howarth, R. Salib, 2003, Drug safety.

Pathogenic mechanisms: a rational basis for treatment

P. Howarth, 1998, BMJ.

BSACI guidelines for the management of allergic and non‐allergic rhinitis

D. Ryan, P. Cullinan, P. Howarth, 2007, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Epithelial IL‐6 trans‐signaling defines a new asthma phenotype with increased airway inflammation

P. Howarth, J. Ward, D. Shaw, 2019, The Journal of allergy and clinical immunology.

Paradoxical bronchoconstriction in asthmatic patients after salmeterol by metered dose inhaler.

P. Howarth, S. Holgate, P. Bradding, 1992, BMJ.

The Effects on Bronchial Epithelial Mucociliary Cultures of Coarse, Fine, and Ultrafine Particulate Matter From an Underground Railway Station

Matthew Loxham, Flemming R. Cassee, Martin R. Palmer, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Asthmatic bronchial epithelium is more susceptible to oxidant-induced apoptosis.

P. Howarth, R. Djukanović, F. Bucchieri, 2001, American journal of respiratory cell and molecular biology.

Airway and peripheral urokinase plasminogen activator receptor is elevated in asthma, and identifies a severe, nonatopic subset of patients

I. Sayers, G. Koppelman, P. Howarth, 2017, Allergy.

The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma

D. Postma, R. Pauwels, P. Howarth, 2003, European Respiratory Journal.

Myofibroblasts and subepithelial fibrosis in bronchial asthma.

P. Howarth, R. Djukanović, S. Holgate, 1990, American journal of respiratory cell and molecular biology.

Cytokines and Airway Inflammation

P. Howarth, S. Holgate, P. Bradding, 1994, Annals of the New York Academy of Sciences.

Exercise and isocapnic hyperventilation-induced bronchoconstriction in asthma: relevance of circulating basophils to measurements of plasma histamine.

P. Howarth, S. Holgate, M. Church, 1984, The Journal of allergy and clinical immunology.

Transforming growth factor‐β in allergic inflammatory disease of the upper airways: friend or foe?

P. Howarth, R. Salib, Peter H. Howarth, 2009, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Exogenous IFN-β has antiviral and anti-inflammatory properties in primary bronchial epithelial cells from asthmatic subjects exposed to rhinovirus.

P. Howarth, S. Holgate, D. Davies, 2011, The Journal of allergy and clinical immunology.

Preliminary study of the cellular characteristics of primary bronchial fibroblasts in patients with asthma: expression of alpha-smooth muscle actin, fibronectin containing extra type III domain A, and smoothelin.

P. Howarth, D. Davies, D. Sammut, 2012, Journal of investigational allergology & clinical immunology.

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA2LEN paper

B. Lambrecht, P. Howarth, H. Schünemann, 2008, Allergy.

S42 Airway epithelial toll receptor expression in asthma and its relationship to disease severity

P. Howarth, H. Haitchi, C. Grainge, 2010, Thorax.

Leucocyte-endothelial adhesion molecules and their role in bronchial asthma and allergic rhinitis.

P. Howarth, S. Holgate, S. Montefort, 1993, The European respiratory journal.

Correction to: Is diet partly responsible for differences in COVID-19 death rates between and within countries?

Ana C. Coelho, Todor A Popov, I. Pavord, 2020, Clinical and Translational Allergy.

A new look at the pathogenesis of asthma

P. Howarth, G. Roberts, S. Holgate, 2009, Clinical science.

The long-acting b2-agonist salmeterol xinafoate: effects on airway inflammation in asthma

P. Howarth, S. Holgate, P. Bradding, 1999 .

Clinical outcomes and adverse effect monitoring in allergic rhinitis.

E. Juniper, P. Howarth, F. Simons, 2005, The Journal of allergy and clinical immunology.

Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma.

P. Howarth, R. Djukanović, S. Holgate, 1992, The American review of respiratory disease.

A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial

I. Pavord, A. Woodcock, P. Howarth, 2018, Trials.

Clinical evaluation of type 2 disease status in a real‐world population of difficult to manage asthma using historic electronic healthcare records of blood eosinophil counts

P. Howarth, R. Djukanović, H. Haitchi, 2021, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Lung function fluctuation patterns unveil asthma and COPD phenotypes unrelated to type 2 inflammation.

P. Howarth, K. Rabe, B. Beghé, 2021, The Journal of allergy and clinical immunology.

IL-17-high asthma with features of a psoriasis immunophenotype.

C. Auffray, P. Howarth, J. Ward, 2019, The Journal of allergy and clinical immunology.

Histamine and the nasal vasculature: the influence of H1 and H2-histamine receptor antagonism.

P. Howarth, L. Lau, R. Wood-Baker, 1996, Clinical otolaryngology and allied sciences.

Randomised controlled trials in severe asthma: selection by phenotype or stereotype

P. Howarth, C. Barber, S. Elliott, 2018, European Respiratory Journal.

Protocol for the Wessex AsThma CoHort of difficult asthma (WATCH): a pragmatic real-life longitudinal study of difficult asthma in the clinic

P. Howarth, R. Djukanović, H. Haitchi, 2019, BMC Pulmonary Medicine.

Regional assessment of lung function using thin-plate splines to align structural and functional imaging

Surussawadi Bennett, Peter Howarth, Michael J. Bennett, 2015, 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

Airway endothelin levels in asthma: influence of endobronchial allergen challenge and maintenance corticosteroid therapy.

P. Howarth, S. Holgate, J. Polak, 1997, The European respiratory journal.

Cytokine immunoreactivity in seasonal rhinitis: regulation by a topical corticosteroid.

P. Howarth, S. Holgate, P. Bradding, 1995, American journal of respiratory and critical care medicine.

Objective monitoring of nasal airway inflammation in rhinitis.

P. Howarth, S. Durham, E. Meltzer, 2005, The Journal of allergy and clinical immunology.

New Perspectives on Difficult Asthma; Sex and Age of Asthma-Onset Based Phenotypes.

P. Howarth, R. Djukanović, H. Haitchi, 2020, The journal of allergy and clinical immunology. In practice.

Signal transducer and activator of transcription 6 (STAT-6) expression and function in asthmatic bronchial epithelium.

P. Howarth, R. Djukanović, F. Bucchieri, 2001, The Journal of allergy and clinical immunology.

Inhibition of Pim1 kinase, new therapeutic approach in virus-induced asthma exacerbations

P. Howarth, M. Nawijn, D. Davies, 2016, European Respiratory Journal.

Interleukin 4 is localized to and released by human mast cells

P. Howarth, C. Heusser, Y. Okayama, 1992, The Journal of experimental medicine.

The expression of leukocyte-endothelial adhesion molecules is increased in perennial allergic rhinitis.

P. Howarth, S. Holgate, S. Montefort, 1992, American journal of respiratory cell and molecular biology.

The relationship between atopic status and IL-10 nasal lavage levels in the acute and persistent inflammatory response to upper respiratory tract infection.

P. Howarth, S. Johnston, J. Corne, 2001, American journal of respiratory and critical care medicine.

Endobronchial ultrasound to assess airway wall thickening: validation in vitro and in vivo

P. Howarth, S. Wilson, J M Turner, 2004, European Respiratory Journal.

IgE and Anti-IgE Therapy in Allergic Asthma and Rhinitis

P. Howarth, S. Holgate, E. Salagean, 2005 .

Asthma in adults and its association with chronic rhinosinusitis: The GA2LEN survey in Europe

D. Jarvis, P. Howarth, J. Bousquet, 2012, Allergy.

Eosinophilic airway diseases: basic science, clinical manifestations and future challenges

C. Porsbjerg, C. Janson, P. Howarth, 2022, European clinical respiratory journal.

Geographical variation in the prevalence of sensitization to common aeroallergens in adults: the GA2LEN survey

D. Jarvis, C. Janson, P. Howarth, 2014, Allergy.

Pharmacologic and anti‐IgE treatment of allergic rhinitis ARIA update (in collaboration with GA2LEN)

R. Dubakiene, Todor A Popov, B. Yawn, 2006, Allergy.

Nocturnal temperature-controlled laminar airflow device for adults with severe allergic asthma: the LASER RCT.

P. Howarth, N. Rahman, R. Luengo-Fernandez, 2019, Health technology assessment.

Nanomechanical assessment of human and murine collagen fibrils via atomic force microscopy cantilever-based nanoindentation.

P. Howarth, D. Davies, P. Thurner, 2014, Journal of the mechanical behavior of biomedical materials.

GA2LEN (Global Allergy and Asthma European Network) addresses the allergy and asthma ‘epidemic’

B. Brunekreef, P. Howarth, H. Schünemann, 2009, Allergy.

Airway epithelial transcription factor NK2 homeobox 1 inhibits mucous cell metaplasia and Th2 inflammation.

P. Howarth, S. Holgate, D. Davies, 2011, American journal of respiratory and critical care medicine.

Small RNA Species and microRNA Profiles are Altered in Severe Asthma Nanovesicles from Broncho Alveolar Lavage and Associate with Impaired Lung Function and Inflammation

P. Howarth, R. Martinez-Nunez, H. Rupani, 2019, Non-coding RNA.

Real-world mepolizumab in the prospective severe asthma REALITI-A study: initial analysis

P. Howarth, G. Canonica, T. Welte, 2020, European Respiratory Journal.

Severe asthma exists despite suppressed tissue inflammation: findings of the U-BIOPRED study

C. Auffray, P. Howarth, A. Bansal, 2016, European Respiratory Journal.

Thin film polycrystalline silicon nanowire biosensors.

Kai Sun, Hywel Morgan, Peter Ashburn, 2012, Nano letters.

Rigor Is Needed When Making Comparative Analyses of Biologics in Severe Asthma.

P. Howarth, C. Prazma, E. Pizzichini, 2018, American journal of respiratory and critical care medicine.

The choice of an H1‐antihistamine for the 21st century

P. Howarth, 2002 .

Toll-like Receptor 7 Is Reduced in Severe Asthma and Linked to an Altered MicroRNA Profile.

P. Howarth, C. Grainge, R. Martinez-Nunez, 2016, American journal of respiratory and critical care medicine.

Erratum to: Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)

D. Postma, I. Pavord, A. Sheikh, 2017, Clinical and Translational Allergy.

Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux

C. Auffray, P. Howarth, Fabio Strazzeri, 2019, European Respiratory Journal.

Eosinophil‐derived neurotoxin and clinical outcomes with mepolizumab in severe eosinophilic asthma

F. Albers, S. Yancey, E. Israel, 2020, Allergy.

Factors affecting adherence with treatment advice in a clinical trial of patients with severe asthma

I. Pavord, A. Woodcock, P. Howarth, 2021, European Respiratory Journal.

Peripheral airways type 2 inflammation, neutrophilia and microbial dysbiosis in severe asthma

P. Howarth, H. Rupani, L. Lau, 2021, Allergy.

Mepolizumab for chronic rhinosinusitis with nasal polyps (SYNAPSE): In‐depth sinus surgery analysis

S. Yancey, P. Howarth, W. Fokkens, 2022, Allergy.

Topical capsaicin therapy in chronic rhinitis: a way forward?

P. Howarth, K. Rajakulasingam, 1991, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

A review of the tolerability and safety of levocabastine eye drops and nasal spray. Implications for patient management

P. Howarth, 1995, Mediators of inflammation.

IgE to Staphylococcus aureus enterotoxins in serum is related to severity of asthma.

Claus Bachert, Peter Howarth, Philippe Gevaert, 2003, The Journal of allergy and clinical immunology.

Mepolizumab Improves Health Related Quality of Life for Patients with Chronic Rhinosinusitis with Nasal Polyps: Data from the SYNAPSE study

S. Yancey, P. Howarth, W. Fokkens, 2021, Journal of Allergy and Clinical Immunology.

Vulnerability to acid reflux of the airway epithelium in severe asthma

P. Howarth, J. Ward, R. Djukanović, 2022, European Respiratory Journal.

Barrier responses of human bronchial epithelial cells to grass pollen exposure

Stephen T. Holgate, Claudia Traidl-Hoffmann, Donna E. Davies, 2012, European Respiratory Journal.

Deaths from low dose paracetamol poisoning

P. Howarth, J. Barnes, M. Abban, 1998, BMJ.

Multidimensional endotypes of asthma: topological data analysis of cross-sectional clinical, pathological, and immunological data

Borislav Dimitrov, Peter Howarth, Tanya Petrossian, 2015, The Lancet.

ALLERGEN AVOIDANCE AND CLINICAL PRACTICE

P. Howarth, 1993 .

Structure–mechanics relationships of collagen fibrils in the osteogenesis imperfecta mouse model

S. J. Shefelbine, P. H. Howarth, P. Howarth, 2015, Journal of The Royal Society Interface.

Is fruit and vegetable intake associated with asthma or chronic rhino-sinusitis in European adults? Results from the Global Allergy and Asthma Network of Excellence (GA2LEN) Survey

C. Janson, P. Howarth, C. Bachert, 2017, Clinical and Translational Allergy.

Mapping atopic dermatitis and anti-IL-22 response signatures to Type 2-low severe neutrophilic asthma.

P. Howarth, G. Roberts, D. Shaw, 2021, The Journal of allergy and clinical immunology.

Instability of sputum molecular phenotypes in U-BIOPRED severe asthma

C. Auffray, P. Howarth, J. Corfield, 2020, European Respiratory Journal.

Topological data analysis (TDA) of U-BIOPRED paediatric peripheral blood gene expression identified asthma phenotypes characterised by alternative splicing of glucocorticoid receptor (GR) mRNA

C. Auffray, P. Howarth, G. Roberts, 2018, Paediatric asthma and allergy.

Sputum proteomic signature of gastro-oesophageal reflux in patients with severe asthma.

C. Auffray, B. Dimitrov, P. Howarth, 2019, Respiratory medicine.

ARIA in the pharmacy: management of allergic rhinitis symptoms in the pharmacy

P. Howarth, J. Bousquet, R. Lockey, 2004, Allergy.

Epithelial-mesenchymal interactions in the pathogenesis of asthma

P. Howarth, S. Holgate, D. Davies, 2003 .

A UK community‐based survey on the prevalence of rhinosinusitis

P. Howarth, G. Scadding, A. Sami, 2018, Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery.

CYTOKINE PRODUCTION BY CELL CULTURES FROM BRONCHIAL SUBEPITHELIAL MYOFIBROBLASTS

P. Howarth, Shaoli Zhang, W. Roche, 1996, The Journal of pathology.

Treating hay fever.

P. Howarth, S. Holgate, S. Miller, 1985, British medical journal.

Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: an exploratory analysis

C. Auffray, P. Howarth, J. Corfield, 2018, European Respiratory Journal.

MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis.

Todor A Popov, I. Pavord, A. Sheikh, 2016, The Journal of allergy and clinical immunology.

Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation

C. Auffray, P. Howarth, K. Rabe, 2021, European Respiratory Journal.

Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort

C. Auffray, H. Bisgaard, P. Howarth, 2015, European Respiratory Journal.