H J Clewell

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Improving toxicology testing protocols using computer simulations.

H J Clewell, M E Andersen, M. Andersen, 1989, Toxicology letters.

Proceedings of the Conference on Chemical Risk Assessment in the DoD: science, Policy, and Practice Held in Dayton, Ohio on April 8-11, 1991

H J Clewell, 1993 .

Investigation of the impact of pharmacokinetic variability and uncertainty on risks predicted with a pharmacokinetic model for chloroform.

H J Clewell, B C Allen, H. Clewell, 1996, Toxicology.

Adjusting exposure limits for long and short exposure periods using a physiological pharmacokinetic model.

D J Paustenbach, H J Clewell, M E Andersen, 1987, American Industrial Hygiene Association journal.

Pharmacodynamic model of the rat estrus cycle in relation to endocrine disruptors.

H J Clewell, M E Andersen, H A Barton, 1997, Journal of toxicology and environmental health.

Evaluating noncancer effects of trichloroethylene: dosimetry, mode of action, and risk assessment.

H J Clewell, H A Barton, H. Clewell, 2000, Environmental health perspectives.

Dermal absorption of organic chemical vapors in rats and humans.

H J Clewell, M E Andersen, M L Gargas, 1990, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Physiologically based pharmacokinetic and pharmacodynamic model for the inhibition of acetylcholinesterase by diisopropylfluorophosphate.

H J Clewell, M E Andersen, R B Conolly, 1990, Toxicology and applied pharmacology.

Physiologically based pharmacokinetic modeling of the pregnant rat: a multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid.

H J Clewell, M E Andersen, D. H. Taylor, 1989, Toxicology and applied pharmacology.

Physiologically-Based Pharmacokinetic Modeling and Bioactivation of Xenobiotics

H J Clewell, M E Andersen, 1994, Toxicology and industrial health.

Development of a physiologically based pharmacokinetic model of isopropanol and its metabolite acetone.

H J Clewell, M E Andersen, M. Andersen, 2001, Toxicological sciences : an official journal of the Society of Toxicology.

Risk assessment of chemical mixtures: biologic and toxicologic issues.

H J Clewell, M M Mumtaz, H. Clewell, 1993, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Derivation of a human equivalent concentration for n-butanol using a physiologically based pharmacokinetic model for n-butyl acetate and metabolites n-butanol and n-butyric acid.

H J Clewell, H A Barton, R A Corley, 2005, Toxicological sciences : an official journal of the Society of Toxicology.

Genetic polymorphisms in assessing interindividual variability in delivered dose.

M L Dourson, H J Clewell, H. Clewell, 2002, Regulatory toxicology and pharmacology : RTP.

A physiological pharmacokinetic model for dermal absorption of vapors in the rat.

H J Clewell, M E Andersen, J N McDougal, 1986, Toxicology and applied pharmacology.

Considering pharmacokinetic and mechanistic information in cancer risk assessments for environmental contaminants: examples with vinyl chloride and trichloroethylene.

H J Clewell, M E Andersen, B C Allen, 1995, Chemosphere.

Incorporating biological information in quantitative risk assessment: an example with methylene chloride.

H J Clewell, 1995, Toxicology.

Pharmacokinetics, biochemical mechanism and mutation accumulation: a comprehensive model of chemical carcinogenesis.

H J Clewell, M E Andersen, R B Conolly, 1988, Toxicology letters.

Use of physiologically based pharmacokinetic modeling to investigate individual versus population risk.

H J Clewell, M E Andersen, M. Andersen, 1996, Toxicology.

Implementation of EPA Revised Cancer Assessment Guidelines: Incorporation of Mechanistic and Pharmacokinetic Data.

H J Clewell, M E Andersen, C B Frederick, 1997, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Comparison of cancer risk estimates for vinyl chloride using animal and human data with a PBPK model.

H J Clewell, M E Andersen, B C Allen, 2001, The Science of the total environment.

Coupling of computer modeling with in vitro methodologies to reduce animal usage in toxicity testing.

H J Clewell, 1993, Toxicology letters.

A physiologically based pharmacokinetic model for retinoic acid and its metabolites.

H J Clewell, M E Andersen, M. Andersen, 1997, Journal of the American Academy of Dermatology.

Development of a physiologically based pharmacokinetic model of trichloroethylene and its metabolites for use in risk assessment.

H J Clewell, H. Clewell, T. Covington, 2000, Environmental health perspectives.

Sensitivity of physiologically based pharmacokinetic models to variation in model parameters: methylene chloride.

H J Clewell, R L Carpenter, H. Clewell, 1994, Risk analysis : an official publication of the Society for Risk Analysis.

Incorporation of pharmacokinetics in noncancer risk assessment: example with chloropentafluorobenzene.

H J Clewell, H. Clewell, B M Jarnot, 1994, Risk analysis : an official publication of the Society for Risk Analysis.

Metabolism of inhaled dihalomethanes in vivo: differentiation of kinetic constants for two independent pathways.

H J Clewell, M E Andersen, M L Gargas, 1986, Toxicology and applied pharmacology.

Physiologically based pharmacokinetic modeling with dichloromethane, its metabolite, carbon monoxide, and blood carboxyhemoglobin in rats and humans.

H J Clewell, M E Andersen, M L Gargas, 1991, Toxicology and applied pharmacology.

Applying simulation modeling to problems in toxicology and risk assessment--a short perspective.

H J Clewell, M E Andersen, C B Frederick, 1995, Toxicology and applied pharmacology.

Kinetics of water vapor sorption in porcine stratum corneum.

H J Clewell, J N McDougal, Z. Liron, 1994, Journal of pharmaceutical sciences.

The application of physiologically based pharmacokinetic modeling in human health risk assessment of hazardous substances.

H J Clewell, H. Clewell, 1995, Toxicology letters.

Quantitative evaluation of the metabolic interactions between trichloroethylene and 1,1-dichloroethylene in vivo using gas uptake methods.

H J Clewell, M E Andersen, M L Gargas, 1987, Toxicology and applied pharmacology.

Determination of a site-specific reference dose for methylmercury for fish-eating populations.

H J Clewell, A M Shipp, H. Clewell, 2000, Toxicology and industrial health.

A physiologically based simulation approach for determining metabolic constants from gas uptake data.

H J Clewell, M E Andersen, M L Gargas, 1986, Toxicology and applied pharmacology.

Biologically motivated models for chemical risk assessment.

H J Clewell, M E Andersen, M. Andersen, 1989, Health physics.

Investigation of the potential impact of benchmark dose and pharmacokinetic modeling in noncancer risk assessment.

H J Clewell, H. Clewell, J. Gearhart, 1997, Journal of toxicology and environmental health.

A physiologically based pharmacokinetic model for inhaled carbon tetrachloride.

D J Paustenbach, H J Clewell, M E Andersen, 1988, Toxicology and applied pharmacology.

Variability of physiologically based pharmacokinetic (PBPK) model parameters and their effects on PBPK model predictions in a risk assessment for perchloroethylene (PCE).

H J Clewell, J W Fisher, H. Clewell, 1993, Toxicology letters.

Dermal absorption of dihalomethane vapors.

H J Clewell, M E Andersen, J N McDougal, 1985, Toxicology and applied pharmacology.

Evaluation of the uncertainty in an oral reference dose for methylmercury due to interindividual variability in pharmacokinetics.

H J Clewell, K S Crump, A M Shipp, 1999, Risk analysis : an official publication of the Society for Risk Analysis.