B. Nielsen

发表

Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer.

O. Vasiljeva, A. Papazoglou, A. Krüger, 2006, Cancer research.

miR-21 expression analysis in budding colon cancer cells by confocal slide scanning microscopy

B. Nielsen, K. Knudsen, J. Lindebjerg, 2018, Clinical & Experimental Metastasis.

Reduced metastasis of transgenic mammary cancer in urokinase‐deficient mice

B. Nielsen, K. Almholt, L. Lund, 2005, International journal of cancer.

Extracellular protease mRNAs are predominantly expressed in the stromal areas of microdissected mouse breast carcinomas.

B. Nielsen, K. Almholt, I. Christensen, 2005, Carcinogenesis.

Efficient identification of miRNAs for classification of tumor origin.

T. Blondal, B. Nielsen, R. Søkilde, 2014, The Journal of molecular diagnostics : JMD.

Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy

B. Nielsen, L. Lund, A. Molinolo, 2005, The Journal of cell biology.

The urokinase receptor associated protein (uPARAP/endo180): a novel internalization receptor connected to the plasminogen activation system.

B. Nielsen, K. Danø, N. Behrendt, 2001, Trends in cardiovascular medicine.

Two distinct expression patterns of urokinase, urokinase receptor and plasminogen activator inhibitor‐1 in colon cancer liver metastases

B. Nielsen, L. Lund, K. Danø, 2009, International journal of cancer.

The collagen receptor uPARAP/Endo180.

B. Nielsen, N. Behrendt, H. J. Jürgensen, 2009, Frontiers in bioscience.

Extracellular Proteolysis in Transgenic Mouse Models of Breast Cancer

B. Nielsen, K. Almholt, L. Lund, 2007, Journal of Mammary Gland Biology and Neoplasia.

MMP-9 Is Differentially Expressed in Primary Human Colorectal Adenocarcinomas and Their Metastases

B. Nielsen, M. Sehested, L. Lund, 2006, Molecular Cancer Research.

The urokinase receptor as a potential target in cancer therapy.

B. Nielsen, M. Ploug, J. Rømer, 2004, Current pharmaceutical design.

Oncostatin M reduces atherosclerosis development in APOE*3Leiden.CETP mice and is associated with increased survival probability in humans

V. Gudnason, V. Emilsson, B. Nielsen, 2019, PloS one.

MicroRNA in situ hybridization.

B. Nielsen, 2012, Methods in molecular biology.

92 kDa type IV collagenase (MMP‐9) is expressed in neutrophils and macrophages but not in malignant epithelial cells in human colon cancer

B. Nielsen, M. Sehested, L. Kjeldsen, 1996, International journal of cancer.

Lung metastasis fails in MMTV-PyMT oncomice lacking S100A4 due to a T-cell deficiency in primary tumors.

B. Nielsen, K. Almholt, M. Grigorian, 2010, Cancer research.

Delineation of matriptase protein expression by enzymatic gene trapping suggests diverging roles in barrier function, hair formation, and squamous cell carcinogenesis.

B. Nielsen, A. Molinolo, T. Bugge, 2006, The American journal of pathology.

Altered expression of the urokinase receptor homologue, C4.4A, in invasive areas of human esophageal squamous cell carcinoma

B. Nielsen, M. Ploug, O. D. Lærum, 2008, International journal of cancer.

Concomitant lack of MMP9 and uPA disturbs physiological tissue remodeling.

B. Nielsen, K. Almholt, I. Christensen, 2011, Developmental biology.

Plasminogen activation independent of uPA and tPA maintains wound healing in gene‐deficient mice

B. Nielsen, K. Almholt, C. Craik, 2006, The EMBO journal.

Award Number: W81XWH-05-1-0272 TITLE: Biological Function of Plasma Kallikrein in Mammary Gland Stromal Development and Tumor Metastasis

B. Nielsen, K. Almholt, C. Craik, 2006 .

Functional overlap between two classes of matrix‐degrading proteases in wound healing

B. Nielsen, L. Lund, K. Danø, 1999, The EMBO journal.

Automated One-Double-Z Pair BaseScope™ for CircRNA In Situ Hybridization.

J. Kjems, B. Nielsen, Trine Møller, 2020, Methods in molecular biology.

Epidermal Growth Factor–like Domain 7 Predicts Response to First-Line Chemotherapy and Bevacizumab in Patients with Metastatic Colorectal Cancer

B. Nielsen, F. B. Sørensen, T. Hansen, 2014, Molecular Cancer Therapeutics.

Matrix Metalloproteinase 13 Is Induced in Fibroblasts in Polyomavirus Middle T Antigen-Driven Mammary Carcinoma without Influencing Tumor Progression

B. Nielsen, Z. Werb, I. Christensen, 2008, PloS one.

The myofibroblast is the predominant plasminogen activator inhibitor-1-expressing cell type in human breast carcinomas.

B. Nielsen, S. Hamilton-Dutoit, J. Overgaard, 2003, The American journal of pathology.

Messenger RNA for urokinase plasminogen activator is expressed in myofibroblasts adjacent to cancer cells in human breast cancer.

B. Nielsen, M. Sehested, K. Danø, 1996, Laboratory investigation; a journal of technical methods and pathology.

Staphylococcus aureus Induces Signal Transducer and Activator of Transcription 5‒Dependent miR-155 Expression in Cutaneous T-Cell Lymphoma

J. Becker, B. Nielsen, T. Litman, 2021, Journal of Investigative Dermatology.

Advances in Brief Sequential Coexpression of the Multidrug Resistance Genes MRP and mdrl and Their Products in VP-16 ( Etoposide )-selected H 69 Small Cell Lung Cancer Cells 1

B. Nielsen, D. Hipfner, S. Cole, 2006 .

Sequential coexpression of the multidrug resistance genes MRP and mdr1 and their products in VP-16 (etoposide)-selected H69 small cell lung cancer cells.

B. Nielsen, M. Sehested, D. Hipfner, 1995, Cancer research.

Human iPSC-derived hepatocytes in 2D and 3D suspension culture for cryopreservation and in vitro toxicity studies.

B. Nielsen, A. Vinggaard, H. Zimmermann, 2022, Reproductive toxicology.

Pharmacokinetics and Pharmacodynamics of a 13-mer LNA-inhibitor-miR-221 in Mice and Non-human Primates

B. Nielsen, C. Mignogna, P. Tassone, 2016, Molecular therapy. Nucleic acids.

Secretion, blood levels and cutaneous expression of TL1A in psoriasis patients

B. Nielsen, K. Holmstrøm, A. Pedersen, 2015, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

An alternatively spliced variant of mRNA for the human receptor for urokinase plasminogen activator

B. Nielsen, L. Lund, K. Danø, 1993, FEBS letters.

Reduced metastasis of Polyoma virus middle T antigen-induced mammary cancer in plasminogen-deficient mice

B. Nielsen, D. Witte, L. Lund, 1998, Oncogene.

Metastasis of transgenic breast cancer in plasminogen activator inhibitor-1 gene-deficient mice

N. Brünner, B. Nielsen, K. Almholt, 2003, Oncogene.

The Urokinase Plasminogen Activator Receptor–Associated Protein/Endo180 Is Coexpressed with Its Interaction Partners Urokinase Plasminogen Activator Receptor and Matrix Metalloprotease-13 during Osteogenesis

B. Nielsen, C. López-Otín, H. Birkedal‐Hansen, 2001, Laboratory Investigation.

Prognosis in adenocarcinomas of lower oesophagus, gastro‐oesophageal junction and cardia evaluated by uPAR‐immunohistochemistry

B. Nielsen, I. Christensen, K. Danø, 2012, International journal of cancer.

Leading-edge myofibroblasts in human colon cancer express plasminogen activator inhibitor-1.

H. Nielsen, B. Nielsen, L. Lund, 2004, American journal of clinical pathology.

Expression of plasminogen activator inhibitor‐1, urokinase receptor and laminin γ‐2 chain is an early coordinated event in incipient oral squamous cell carcinoma

B. Nielsen, P. Lindberg, Åke Larsson, 2006, International journal of cancer.

Expression of urokinase plasminogen activator, its receptor and type‐1 inhibitor in malignant and benign prostate tissue

N. Brünner, B. Nielsen, K. Danø, 2005, International journal of cancer.

Companion Diagnostics and Cancer Biomarkers Epidermal Growth Factor – like Domain 7 Predicts Response to First-Line Chemotherapy and Bevacizumab in Patients with Metastatic Colorectal Cancer

B. Nielsen, F. B. Sørensen, T. Hansen, 2014 .

Matrix metalloproteinase-2 is expressed in melanoma-associated spongiform scleropathy.

B. Nielsen, S. Heegaard, J. Prause, 2008, Investigative ophthalmology & visual science.

The Murine Receptor for Urokinase-Type Plasminogen Activator Is Primarily Expressed in Tissues Actively Undergoing Remodeling

B. Nielsen, L. Lund, M. Ploug, 2001, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

MicroRNA-27a-3p targets FoxO signalling to induce tumour-like phenotypes in bile duct cells.

B. Nielsen, L. Roberts, J. Koshiol, 2022, Journal of hepatology.

Lactational competence and involution of the mouse mammary gland require plasminogen.

B. Nielsen, Z. Werb, I. Christensen, 2000, Development.

Lack of plasminogen leads to milk stasis and premature mammary gland involution during lactation.

B. Nielsen, L. Lund, F. Castellino, 2006, Developmental biology.

The Urokinase Plasminogen Activation System in Breast Cancer

N. Brünner, B. Nielsen, A. N. Pedersen, 1999 .

Immunohistochemical detection of DNA topoisomerase IIalpha, P-glycoprotein and multidrug resistance protein (MRP) in small-cell and non-small-cell lung cancer.

B. Nielsen, M. Sehested, P. B. Jensen, 1998, British Journal of Cancer.

Crohn's Disease But Not Chronic Ulcerative Colitis Induces the Expression of PAI-1 in Enteric Neurons

B. Nielsen, K. Danø, O. Laerum, 2008, The American Journal of Gastroenterology.

Estrogen Receptor-α Quantification in Breast Cancer: Concordance Between Immunohistochemical Assays and mRNA-In Situ Hybridization for ESR1 Gene

B. Nielsen, M. Vyberg, S. Nielsen, 2019, Applied immunohistochemistry & molecular morphology : AIMM.

Biosynthesis of granule proteins in normal human bone marrow cells. Gelatinase is a marker of terminal neutrophil differentiation.

B. Nielsen, M. Sehested, H. Sengeløv, 1995, Blood.

Localization of tissue inhibitor of metalloproteinases 1 (TIMP‐1) in human colorectal adenoma and adenocarcinoma

H. Nielsen, N. Brünner, B. Nielsen, 2005, International journal of cancer.

MicroRNA Biomarkers in IBD—Differential Diagnosis and Prediction of Colitis-Associated Cancer

B. Nielsen, E. Langholz, E. Høgdall, 2020, International journal of molecular sciences.

MiR-21 expression in the tumor cell compartment holds unfavorable prognostic value in gliomas

B. Nielsen, S. Hansen, B. Kristensen, 2012, Journal of Neuro-Oncology.

Excerpts from the 1st international NTNU symposium on current and future clinical biomarkers of cancer: innovation and implementation, June 16th and 17th 2016, Trondheim, Norway

A. Børresen-Dale, P. Sætrom, B. Nielsen, 2016, Journal of Translational Medicine.

Evaluation of fluorescence in situ hybridization techniques to study long non-coding RNA expression in cultured cells

B. Nielsen, A. Lund, K. Holmstrøm, 2017, Nucleic acids research.

High levels of microRNA-21 in the stroma of colorectal cancers predict short disease-free survival in stage II colon cancer patients

H. Nielsen, N. Brünner, B. Nielsen, 2010, Clinical & Experimental Metastasis.

microRNA-17 Is the Most Up-Regulated Member of the miR-17-92 Cluster during Early Colon Cancer Evolution

B. Nielsen, K. Knudsen, J. Lindebjerg, 2015, PloS one.

Gene-expression analysis of a colorectal cancer-specific discriminatory transcript set on formalin-fixed, paraffin-embedded (FFPE) tissue samples

B. Nielsen, A. Kalmár, B. Molnár, 2015, Diagnostic Pathology.

Heterogeneity of miRNA expression in localized prostate cancer with clinicopathological correlations

B. Nielsen, F. B. Sørensen, T. Hansen, 2017, PloS one.

Co-staining of microRNAs and their target proteins by miRNA in situ hybridization and immunohistofluorescence on prostate cancer tissue microarrays

T. Wittenberg, G. Kristiansen, B. Nielsen, 2019, Laboratory Investigation.

A precise and efficient stereological method for determining murine lung metastasis volumes.

B. Nielsen, I. Christensen, L. Lund, 2001, The American journal of pathology.

Urokinase plasminogen activator receptor is expressed in invasive cells in gastric carcinomas from high‐ and low‐risk countries

B. Nielsen, L. Lund, O. Laerum, 2010, International journal of cancer.

Combined MicroRNA In Situ Hybridization and Immunohistochemical Detection of Protein Markers.

B. Nielsen, K. Holmstrøm, 2019, Methods in molecular biology.

Combined microRNA in situ hybridization and immunohistochemical detection of protein markers.

B. Nielsen, K. Holmstrøm, 2012, Methods in molecular biology.

Intratumoral Heterogeneity of MicroRNA Expression in Rectal Cancer

B. Nielsen, F. B. Sørensen, T. Hansen, 2016, PloS one.

miR-21 Is Linked to Glioma Angiogenesis

B. Nielsen, B. Kristensen, S. K. Hermansen, 2016, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Immunohistochemical identification of the receptor for urokinase plasminogen activator associated with fibrin deposition in normal and ectopic human placenta.

B. Nielsen, E. Rønne, P. Kaufmann, 1998, Placenta.

Quality control of immunohistochemical evaluation of tumour-associated plasminogen activators and related components. European BIOMED-1 Concerted Action on Clinical Relevance of Proteases in Tumour Invasion and Metastasis.

B. Nielsen, D. Ruiter, M. Schmitt, 1998, European journal of cancer.

Induction of NGAL synthesis in epithelial cells of human colorectal neoplasia and inflammatory bowel diseases.

B. Nielsen, M. Sehested, L. Kjeldsen, 1996, Gut.

MicroRNA In Situ Hybridization in Paraffin-Embedded Cultured Cells.

B. Nielsen, Trine Møller, Jaslin P James, 2020, Methods in molecular biology.

Spontaneous lung and lymph node metastasis in transgenic breast cancer is independent of the urokinase receptor uPAR

B. Nielsen, K. Almholt, L. Lund, 2015, Clinical & Experimental Metastasis.

Systemic administration of anti‐urokinase plasminogen activator receptor monoclonal antibodies induces hepatic fibrin deposition in tissue‐type plasminogen activator deficient mice

B. Nielsen, L. Lund, K. Danø, 2007, Journal of thrombosis and haemostasis : JTH.

Structural analysis and tissue localization of human C4.4A: a protein homologue of the urokinase receptor.

Ole N Jensen, B. Nielsen, L. Lund, 2004, The Biochemical journal.

Collagenase-3 expression in breast myofibroblasts as a molecular marker of transition of ductal carcinoma in situ lesions to invasive ductal carcinomas.

B. Nielsen, C. López-Otín, L. Lund, 2001, Cancer research.

The miRNA-200 family and miRNA-9 exhibit differential expression in primary versus corresponding metastatic tissue in breast cancer

H. Ditzel, B. Nielsen, R. Søkilde, 2012, Breast Cancer Research and Treatment.

MicroRNA-200b is downregulated in colon cancer budding cells

B. Nielsen, K. Knudsen, J. Lindebjerg, 2017, PloS one.

STAT5 induces miR-21 expression in cutaneous T cell lymphoma

B. Nielsen, D. Sasseville, C. Geisler, 2016, Oncotarget.

STAT5 induces miR-21 expression in cutaneous T cell lymphoma

B. Nielsen, D. Sasseville, C. Geisler, 2016, Oncotarget.

Cancer invasion and tissue remodeling‐cooperation of protease systems and cell types

B. Nielsen, L. Lund, J. Rygaard, 1999, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

Stromal cells associated with early invasive foci in human mammary ductal carcinoma in situ coexpress urokinase and urokinase receptor

B. Nielsen, L. Lund, K. Danø, 2007, International journal of cancer.

Urokinase Plasminogen Activator Is Localized in Stromal Cells in Ductal Breast Cancer

B. Nielsen, M. Sehested, J. Rygaard, 2001, Laboratory Investigation.

Expression of miR‐155 and miR‐126 in situ in cutaneous T‐cell lymphoma

B. Nielsen, R. Gniadecki, A. Woetmann, 2013, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation.

B. Nielsen, J. Gutkind, A. Molinolo, 2005, Genes & development.

Detection of plasminogen activators in oral cancer by laser capture microdissection combined with zymography.

B. Nielsen, J. Myers, J. Ensley, 2004, Oral oncology.

Detection of lncRNA by LNA-Based In Situ Hybridization in Paraffin-Embedded Cancer Cell Spheroids.

B. Nielsen, K. Holmstrøm, J. Larsen, 2021, Methods in molecular biology.

LncRNA-OIS1 regulates DPP4 activation to modulate senescence induced by RAS

R. Elkon, B. Nielsen, R. Agami, 2018, Nucleic acids research.

Direct evidence of the importance of stromal urokinase plasminogen activator (uPA) in the growth of an experimental human breast cancer using a combined uPA gene-disrupted and immunodeficient xenograft model.

N. Brünner, P. Carmeliet, B. Nielsen, 2001, Cancer research.

Epigenetic alterations of the SERPINE1 gene in oral squamous cell carcinomas and normal oral mucosa

B. Nielsen, P. Andreasen, J. A. Sørensen, 2010, Genes, chromosomes & cancer.

Expression and cellular localization of the urokinase‐type plasminogen activator and its receptor in human hepatocellular carcinoma

B. Nielsen, B. le Bail, P. Bioulac-Sage, 2000, The Journal of pathology.

Urokinase receptor‐associated protein (UPARAP) is expressed in connection with malignant as well as benign lesions of the human breast and occurs in specific populations of stromal cells

B. Nielsen, K. Danø, N. Behrendt, 2002, International journal of cancer.

Molecular Traits of the Budding Colorectal Cancer Cells

B. Nielsen, 2012 .

Neutralisation of uPA with a Monoclonal Antibody Reduces Plasmin Formation and Delays Skin Wound Healing in tPA-Deficient Mice

B. Nielsen, L. Lund, M. Ploug, 2010, PloS one.

Differential Expression of miR-155 and miR-21 in Tumor and Stroma Cells in Diffuse Large B-Cell Lymphoma

C. Hother, B. Nielsen, K. Grønbæk, 2015, Applied immunohistochemistry & molecular morphology : AIMM.

Expression of matrix metalloprotease-9 in vascular pericytes in human breast cancer.

B. Nielsen, M. Sehested, L. Kjeldsen, 1997, Laboratory investigation; a journal of technical methods and pathology.

miR-21 Expression in Cancer Cells may Not Predict Resistance to Adjuvant Trastuzumab in Primary Breast Cancer

B. Nielsen, E. Balslev, K. Holmstrøm, 2014, Front. Oncol..

Mucosal microRNAs relate to age and severity of disease in ulcerative colitis

B. Nielsen, L. Riis, M. Malham, 2021, Aging.

Co-Detection of miR-21 and TNF-α mRNA in Budding Cancer Cells in Colorectal Cancer

B. Nielsen, J. Lindebjerg, F. B. Sørensen, 2019, International journal of molecular sciences.

University of Southern Denmark Co-detection of miR-21 and TNF-α mRNA in budding cancer cells in colorectal cancer

B. Nielsen, J. Lindebjerg, F. B. Sørensen, 2019 .

Quantification of microRNA-21 and microRNA-125b in melanoma tissue

B. Nielsen, S. Hamilton-Dutoit, H. Schmidt, 2017, Melanoma research.

Immunolymphoscintigraphy for Metastatic Sentinel Nodes: Test of a Model

B. Nielsen, B. Hesse, C. Ingvar, 2011, International journal of molecular imaging.

( Etoposide )-selected H 69 Small Cell Lung Cancer Cells and Their Products in VP-16 mdr 1 and MRP Sequential Coexpression of the Multidrug Resistance Genes

B. Nielsen, D. Hipfner, S. Cole, 2006 .

Integrated Human Evaluation of the Lysophosphatidic Acid Pathway as a Novel Therapeutic Target in Atherosclerosis

V. Emilsson, B. Nielsen, P. Eriksson, 2018, Molecular Therapy: Methods & Clinical Development.

Neutrophil gelatinase-associated lipocalin (NGAL/Lcn2) is upregulated in gastric mucosa infected with Helicobacter pylori

B. Nielsen, L. Lund, O. Laerum, 2009, Virchows Archiv.

Monocyte Infiltration and Differentiation in 3D Multicellular Spheroid Cancer Models

B. Nielsen, S. Skov, M. Gad, 2021, Pathogens.

Robust one-day in situ hybridization protocol for detection of microRNAs in paraffin samples using LNA probes.

B. Nielsen, S. Møller, A. Baker, 2010, Methods.

The prognostic importance of miR-21 in stage II colon cancer: a population-based study

B. Nielsen, J. Lindebjerg, T. Hansen, 2012, British Journal of Cancer.

Tissue MicroRNAs as Predictors of Outcome in Patients with Metastatic Colorectal Cancer Treated with First Line Capecitabine and Oxaliplatin with or without Bevacizumab

B. Nielsen, T. Hansen, P. Pfeiffer, 2014, PloS one.

Selecting optimal spectral bands for improved detection of autofluorescent biomarkers in multiphoton microscopy

Dominik Marti, Peter Andersen, Björn-Ole Meyer, 2020, Journal of biomedical optics.

Excerpts from the 1st international NTNU symposium on current and future clinical biomarkers of cancer: innovation and implementation, June 16th and 17th 2016, Trondheim, Norway

A. Børresen-Dale, P. Sætrom, B. Nielsen, 2016, Journal of Translational Medicine.

miR-21 expression analysis in budding colon cancer cells by confocal slide scanning microscopy

B. Nielsen, K. Knudsen, J. Lindebjerg, 2018, Clinical & Experimental Metastasis.

Intra-tumoural vessel area estimated by expression of epidermal growth factor-like domain 7 and microRNA-126 in primary tumours and metastases of patients with colorectal cancer: a descriptive study

B. Nielsen, F. B. Sørensen, T. Hansen, 2015, Journal of Translational Medicine.

Visualising and quantifying angiogenesis in metastatic colorectal cancer

B. Nielsen, F. B. Sørensen, T. Hansen, 2013, Cellular Oncology.

Elevated microRNA-126 is associated with high vascular endothelial growth factor receptor 2 expression levels and high microvessel density in colorectal cancer.

I. Brandslund, C. Andersen, B. Nielsen, 2011, Oncology letters.

Chromogenic In Situ Hybridization Methods for microRNA Biomarker Monitoring of Drug Safety and Efficacy.

B. Nielsen, Tina Damgaard, B. Gould, 2017, Methods in molecular biology.

In Situ Hybridization Protocols

B. Nielsen, 2014, Methods in Molecular Biology.

Chromogen detection of microRNA in frozen clinical tissue samples using LNA™ probe technology.

B. Nielsen, K. Holmstrøm, Trine Møller, 2014, Methods in molecular biology.

Pleiotropic actions of miR-21 highlight the critical role of deregulated stromal microRNAs during colorectal cancer progression

B. Nielsen, G. Packham, M. Bullock, 2013, Cell Death and Disease.