T. Reinheckel

发表

Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer.

O. Vasiljeva, A. Papazoglou, A. Krüger, 2006, Cancer research.

Cathepsin L is crucial for the development of early experimental diabetic nephropathy.

T. Reinheckel, T. Rabelink, F. Russel, 2016, Kidney international.

Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis

T. Reinheckel, O. Schilling, J. Kizhakkedathu, 2013, Cellular and Molecular Life Sciences.

The lysosomal cysteine protease cathepsin L regulates keratinocyte proliferation by control of growth factor recycling

C. Peters, T. Reinheckel, D. Tobin, 2005, Journal of Cell Science.

Evaluation of UVA‐Mediated Oxidative Damage to Proteins and Lipids in Extracorporeal Photoimmunotherapy

T. Reinheckel, H. Gollnick, W. Halangk, 1999, Photochemistry and photobiology.

Stress-resistant Translation of Cathepsin L mRNA in Breast Cancer Progression*

T. Reinheckel, E. Stickeler, M. Gajda, 2015, The Journal of Biological Chemistry.

Cell Type-specific Functions of the Lysosomal Protease Cathepsin L in the Heart*

O. Vasiljeva, C. Peters, T. Reinheckel, 2007, Journal of Biological Chemistry.

Toward Computer-Based Cleavage Site Prediction of Cysteine Endopeptidases

Christoph Peters, Thomas Dandekar, Thomas Reinheckel, 2003, Biological chemistry.

CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival.

T. Reinheckel, W. Ju, M. Bitzer, 2011, The Journal of clinical investigation.

Cysteine cathepsins are not involved in Fas/CD95 signalling in primary skin fibroblasts

C. Peters, T. Reinheckel, V. Turk, 2007, FEBS letters.

Electrophoretic evidence for the impairment of complexes of the respiratory chain during iron/ascorbate induced peroxidation in isolated rat liver mitochondria.

T. Reinheckel, I. Wiswedel, W. Augustin, 1995, Biochimica et biophysica acta.

LIMP-2 Links Late Phagosomal Trafficking with the Onset of the Innate Immune Response to Listeria monocytogenes

T. Reinheckel, P. Saftig, Estela Rodríguez-Del Río, 2010, The Journal of Biological Chemistry.

Genetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor protein.

C. Peters, T. Reinheckel, M. Kindy, 2009, Biochemical and biophysical research communications.

Presentation In Vitro and In Vivo Distinct Protease Requirements for Antigen

J. Deussing, C. Peters, T. Reinheckel, 2017 .

Asparagine endopeptidase is required for normal kidney physiology and homeostasis

T. Reinheckel, C. Watts, S. Fleming, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Distinct Protease Requirements for Antigen Presentation In Vitro and In Vivo

J. Deussing, C. Peters, T. Reinheckel, 2010, The Journal of Immunology.

Katrin TRANSPORT , AND ACTIVITY PROCESSING , GLYCOSYLATION , Arylsulfatase G : EXPRESSION , Molecular Characterization of Molecular Bases of Disease

T. Dierks, T. Reinheckel, M. Damme, 2014 .

Proteolytic cleavage of the disease-related lysosomal membrane glycoprotein CLN7.

T. Reinheckel, S. Storch, Joshua A Froemming, 2012, Biochimica et biophysica acta.

Comparative resistance of the 20S and 26S proteasome to oxidative stress.

T. Reinheckel, K. Davies, O. Ullrich, 1998, The Biochemical journal.

Decreased arthritis severity in cathepsin L-deficient mice is attributed to an impaired T helper cell compartment

C. Peters, T. Reinheckel, R. Bräuer, 2012, Inflammation Research.

Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient mice

L. Pennacchio, C. Peters, T. Reinheckel, 2006, Biological chemistry.

Osteoclastic Bone Degradation and the Role of Different Cysteine Proteinases and Matrix Metalloproteinases: Differences Between Calvaria and Long Bone

C. Peters, T. Reinheckel, P. Saftig, 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Deletion of Cysteine Cathepsins B or L Yields Differential Impacts on Murine Skin Proteome and Degradome*

T. Reinheckel, M. Boerries, H. Busch, 2012, Molecular & Cellular Proteomics.

Cathepsin L and Arg/Lys aminopeptidase: a distinct prohormone processing pathway for the biosynthesis of peptide neurotransmitters and hormones

M. Bogyo, C. Peters, T. Reinheckel, 2004, Biological chemistry.

The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles.

C. Peters, T. Reinheckel, R. Schüle, 2004, European journal of cell biology.

RNA interference screens discover proteases as synthetic lethal partners of PI3K inhibition in breast cancer cells

T. Reinheckel, M. Boerries, T. Brummer, 2022, Theranostics.

MMP14 empowers tumor‐initiating breast cancer cells under hypoxic nutrient‐depleted conditions

T. Reinheckel, M. Boerries, H. Busch, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L.

T. Reinheckel, P. Saftig, B. Schröder, 2011, The Biochemical journal.

The cystatin M/E‐cathepsin L balance is essential for tissue homeostasis in epidermis, hair follicles, and cornea

T. Reinheckel, J. Schalkwijk, K. Hitomi, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Gene Targeting of the Cysteine Peptidase Cathepsin H Impairs Lung Surfactant in Mice

J. Deussing, C. Peters, T. Reinheckel, 2011, PloS one.

Adaptation of protein carbonyl detection to the requirements of proteome analysis demonstrated for hypoxia/reoxygenation in isolated rat liver mitochondria.

T. Reinheckel, S. Möhring, W. Halangk, 2000, Archives of biochemistry and biophysics.

CA/C1 peptidases of the malaria parasites Plasmodium falciparum and P. berghei and their mammalian hosts – a bioinformatical analysis

C. Peters, T. Reinheckel, T. Dandekar, 2009, Biological chemistry.

Exploring Systemic Functions of Lysosomal Proteases: The Perspective of Genetically Modified Mouse Models

C. Peters, T. Reinheckel, Martina Gansz, 2013 .

Poly-ADP ribose polymerase activates nuclear proteasome to degrade oxidatively damaged histones.

T. Reinheckel, K. Davies, O. Ullrich, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Cathepsin H functions as an aminopeptidase in secretory vesicles for production of enkephalin and galanin peptide neurotransmitters

C. Peters, T. Reinheckel, Lydiane Funkelstein, 2012, Journal of neurochemistry.

Cathepsin L plays a major role in cholecystokinin production in mouse brain cortex and in pituitary AtT-20 cells: Protease gene knockout and inhibitor studies

C. Peters, T. Reinheckel, T. Foulon, 2009, Peptides.

Early trypsin activation develops independently of autophagy in caerulein-induced pancreatitis in mice

T. Reinheckel, J. Mayerle, M. Lerch, 2019, Cellular and Molecular Life Sciences.

Impaired turnover of autophagolysosomes in cathepsin L deficiency

C. Peters, T. Reinheckel, D. Tobin, 2010, Biological chemistry.

Degradation of hypochlorite-damaged glucose-6-phosphate dehydrogenase by the 20S proteasome.

T. Reinheckel, O. Ullrich, T. Grune, 1999, Free radical biology & medicine.

Occurrence of oxidatively modified proteins: an early event in experimental acute pancreatitis.

T. Reinheckel, H. Lippert, H. Schulz, 1998, Free radical biology & medicine.

Cathepsins D and L reduce the toxicity of advanced glycation end products.

T. Reinheckel, T. Grune, S. Grimm, 2012, Free radical biology & medicine.

Proteomic analysis of lung metastases in a murine breast cancer model reveals divergent influence of CTSB and CTSL overexpression

T. Reinheckel, O. Schilling, M. Biniossek, 2017, Journal of Cancer.

Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders

C. Peters, T. Reinheckel, Vivian V. H. Hook, 2022, Pharmacological Reviews.

Cathepsin B in Antigen-Presenting Cells Controls Mediators of the Th1 Immune Response during Leishmania major Infection

T. Reinheckel, M. Lutz, T. Schirmeister, 2014, PLoS neglected tropical diseases.

Cathepsin L Activity Is Essential to Elastase Perfusion–Induced Abdominal Aortic Aneurysms in Mice

P. Libby, C. Peters, T. Reinheckel, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Unconventional Trafficking of Mammalian Phospholipase D3 to Lysosomes.

T. Reinheckel, P. Saftig, M. Schweizer, 2018, Cell reports.

Human Cathepsin V Protease Participates in Production of Enkephalin and NPY Neuropeptide Neurotransmitters*

D. O'Connor, C. Peters, T. Reinheckel, 2012, The Journal of Biological Chemistry.

Major Role of Cathepsin L for Producing the Peptide Hormones ACTH, β-Endorphin, and α-MSH, Illustrated by Protease Gene Knockout and Expression*

C. Peters, T. Reinheckel, F. Beuschlein, 2008, Journal of Biological Chemistry.

Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice.

C. Peters, T. Reinheckel, J. Mayerle, 2010, Gastroenterology.

Cathepsin D exacerbates SPARC-driven aggressiveness by limited proteolysis in triple-negative breast cancer

Pitter F. Huesgen, T. Reinheckel, C. Overall, 2020, bioRxiv.

Cardiac and Ocular Pathologies in a Mouse Model of Mucopolysaccharidosis Type VI

C. Peters, T. Reinheckel, J. Stypmann, 2003, Pediatric Research.

Differential regulation of progranulin derived granulin peptides

T. Reinheckel, Fenghua Hu, H. Du, 2021, bioRxiv.

Cathepsin Protease Controls Copper and Cisplatin Accumulation via Cleavage of the Ctr1 Metal-binding Ectodomain*♦

D. Thiele, T. Reinheckel, B. Turk, 2016, The Journal of Biological Chemistry.

Cathepsin L is involved in cathepsin D processing and regulation of apoptosis in A549 human lung epithelial cells

C. Peters, T. Reinheckel, T. Welte, 2004, Biological chemistry.

Cathepsin L participates in the production of neuropeptide Y in secretory vesicles, demonstrated by protease gene knockout and expression

C. Peters, T. Reinheckel, Shin‐Rong Hwang, 2008, Journal of neurochemistry.

Lysosomal processing of progranulin

T. Reinheckel, Tuancheng Feng, Fenghua Hu, 2017, Molecular Neurodegeneration.

Nitric oxide produced in rat liver mitochondria causes oxidative stress and impairment of respiration after transient hypoxia

T. Reinheckel, W. Augustin, L. Schild, 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Cathepsin BGeneKnockout Improves Behavioral Deficits andReduces Pathology inModels of Neurologic Disorders

C. Peters, T. Reinheckel, Vivian V. H. Hook, 2022 .

Low doses of cholera toxin and its mediator cAMP induce CTLA-2 secretion by dendritic cells to enhance regulatory T cell conversion

T. Reinheckel, V. Pavlovic, S. Kneitz, 2017, PloS one.

Studies of intestinal morphology and cathepsin B expression in a transgenic mouse aiming at intestine-specific expression of Cath B-EGFP

T. Reinheckel, R. Schüle, T. Günther, 2011, Biological chemistry.

Cathepsin H Is an Additional Convertase of Pro-granzyme B

C. Peters, T. Reinheckel, J. Trapani, 2010, The Journal of Biological Chemistry.

Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism

T. Reinheckel, M. Trost, T. Heunis, 2022, bioRxiv.

CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival (The Journal of Clinical Investigation (2011) 121, 10, (3965-3980) DOI: 10.1172/JCI58552)

T. Reinheckel, W. Ju, M. Bitzer, 2012 .

Degradome-focused RNA interference screens to identify proteases important for breast cancer cell growth

T. Reinheckel, T. Brummer, C. Miething, 2022, Frontiers in Oncology.

Calvarial Osteoclasts Express a Higher Level of Tartrate-Resistant Acid Phosphatase than Long Bone Osteoclasts and Activation Does not Depend on Cathepsin K or L Activity

T. Reinheckel, P. Saftig, V. Everts, 2006, Calcified Tissue International.

Neutrophil and Alveolar Macrophage-Mediated Innate Immune Control of Legionella pneumophila Lung Infection via TNF and ROS

T. Reinheckel, A. Oxenius, Pascal Ziltener, 2016, PLoS pathogens.

Cathepsin E Deficiency Ameliorates Graft-versus-Host Disease and Modifies Dendritic Cell Motility

T. Reinheckel, Liane Babes, O. Penack, 2017, Front. Immunol..

Nuclear cathepsin D enhances TRPS1 transcriptional repressor function to regulate cell cycle progression and transformation in human breast cancer cells

T. Reinheckel, S. Pattingre, L. Linares, 2015, Oncotarget.

Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L

C. Peters, T. Reinheckel, J. Trapani, 2010, Immunology.

Discordance in cathepsin B and cystatin C expressions in bronchoalveolar fluids between murine bleomycin-induced fibrosis and human idiopathic fibrosis

T. Reinheckel, S. Marchand-Adam, I. Couillin, 2016, Respiratory Research.

Oxidative stress in lung tissue induced by CO2 pneumoperitoneum in the rat

T. Reinheckel, H. Lippert, H. Schulz, 2000, Surgical Endoscopy.

Role of endogenous and exogenous antioxidants in the defence against functional damage and lipid peroxidation in rat liver mitochondria

T. Reinheckel, I. Wiswedel, W. Augustin, 2004, Molecular and Cellular Biochemistry.

Cathepsin B release from rodent intestine mucosa due to mechanical injury results in extracellular matrix damage in early post-traumatic phases

C. Peters, T. Reinheckel, S. Wehner, 2009, Biological chemistry.

Towards Specific Functions of Lysosomal Cysteine Peptidases: Phenotypes of Mice Deficient for Cathepsin B or Cathepsin L

J. Deussing, C. Peters, T. Reinheckel, 2001, Biological chemistry.

Decreased arthritis severity in cathepsin L-deficient mice is attributed to an impaired T helper cell compartment

C. Peters, T. Reinheckel, B. Wiederanders, 2012, Inflammation Research.

Differentially expressed genes in hippocampal cell cultures in response to an excitotoxic insult by quinolinic acid.

T. Reinheckel, G. Keilhoff, B. Seidel, 1998, Brain research. Molecular brain research.

Comparison of protein oxidation and aldehyde formation during oxidative stress in isolated mitochondria.

T. Reinheckel, I. Wiswedel, W. Augustin, 1998, Free radical research.

Oxidative Stress Affects Pancreatic Proteins during the Early Pathogenesis of Rat Caerulein Pancreatitis

T. Reinheckel, H. Lippert, H. Schulz, 1999, Digestion.

Cathepsin D regulates cathepsin B activation and disease severity predominantly in inflammatory cells during experimental pancreatitis

T. Reinheckel, J. Mayerle, M. Lerch, 2017, The Journal of Biological Chemistry.

Cathepsin protease activity modulates amyloid load in extracerebral amyloidosis

T. Reinheckel, R. Ménard, P. Saftig, 2006, The Journal of pathology.

Expression of human cathepsin L or human cathepsin V in mouse thymus mediates positive selection of T helper cells in cathepsin L knock-out mice.

C. Peters, T. Reinheckel, L. Sevenich, 2010, Biochimie.

Neuroectoderm-specific deletion of cathepsin D in mice models human inherited neuronal ceroid lipofuscinosis type 10.

T. Reinheckel, Susanne Dollwet-Mack, U. Reif, 2016, Biochimie.

Short-term impairment of energy production in isolated rat liver mitochondria by hypoxia/reoxygenation: involvement of oxidative protein modification.

T. Reinheckel, I. Wiswedel, W. Augustin, 1997, The Biochemical journal.

STAT3 expression, activity and functional consequences of STAT3 inhibition in esophageal squamous cell carcinomas and Barrett’s adenocarcinomas

D Hauschke, T. Reinheckel, M. Boerries, 2014, Oncogene.

Cell type-dependent pathogenic functions of overexpressed human cathepsin B in murine breast cancer progression

Bonnie F. Sloane, C. Peters, T. Reinheckel, 2014, Oncogene.

Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis.

H Lippert, J. Deussing, C. Peters, 2000, The Journal of clinical investigation.

Intracellular Complement Activation Sustains T Cell Homeostasis and Mediates Effector Differentiation

T. Reinheckel, M. Kolev, A. Cope, 2013, Immunity.

Differential impairment of 20S and 26S proteasome activities in human hematopoietic K562 cells during oxidative stress.

T. Reinheckel, O. Ullrich, T. Grune, 2000, Archives of biochemistry and biophysics.

Specialized roles for cysteine cathepsins in health and disease.

T. Reinheckel, B. Adair, J. Reiser, 2010, The Journal of clinical investigation.

The lysosomal protease cathepsin L is an important regulator of keratinocyte and melanocyte differentiation during hair follicle morphogenesis and cycling.

C. Peters, T. Reinheckel, D. Tobin, 2002, The American journal of pathology.

Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix

Laura H. Tang, C. Peters, T. Reinheckel, 2014, Genes & development.

Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation

C. Peters, T. Reinheckel, L. Scapozza, 2008, The Journal of experimental medicine.

Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis

T. Reinheckel, R. Backofen, C. Kreutz, 2023, Science Signaling.

Lysosomal processing of progranulin

T. Reinheckel, Tuancheng Feng, Fenghua Hu, 2017, Molecular Neurodegeneration.

Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes

C. Borner, T. Reinheckel, P. Ekert, 2010, Cell Death and Differentiation.

Inherited diseases caused by mutations in cathepsin protease genes

T. Reinheckel, A. Petrera, Alejandro Gomez-Auli, 2017, The FEBS journal.

Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice

O. Vasiljeva, J. Deussing, C. Peters, 2010, Proceedings of the National Academy of Sciences.

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

K. Moore, T. Reinheckel, V. Hornung, 2008, Nature Immunology.

A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis

Stuart J. Brown, W. Cookson, T. Reinheckel, 2017, The Journal of allergy and clinical immunology.

Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice

C. Peters, T. Reinheckel, M. Gajda, 2011, Oncogene.

BRAFV600E drives dedifferentiation in small intestinal and colonic organoids and cooperates with mutant p53 and Apc loss in transformation

T. Reinheckel, M. Boerries, T. Brummer, 2020, Oncogene.

Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice

T. Reinheckel, D. Tuveson, F. Karreth, 2011, Gut.

Deletion of cathepsin H perturbs angiogenic switching, vascularization and growth of tumors in a mouse model of pancreatic islet cell cancer

C. Peters, T. Reinheckel, J. Joyce, 2010, Biological chemistry.

Roles of Cysteine Proteases in Tumor Progression: Analysis of Cysteine Cathepsin Knockout Mice in Cancer Models

C. Peters, T. Reinheckel, J. Joyce, 2008 .

Distinct roles for cysteine cathepsin genes in multistage tumorigenesis.

D. Hanahan, C. Peters, T. Reinheckel, 2006, Genes & development.

Degradation of Oxidized Proteins in K562 Human Hematopoietic Cells by Proteasome*

T. Reinheckel, K. Davies, T. Grune, 1996, The Journal of Biological Chemistry.

The endolysosomal cysteine cathepsins L and K are involved in macrophage‐mediated clearance of Staphylococcus aureus and the concomitant cytokine induction

C. Peters, T. Reinheckel, P. Saftig, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Specific functions of lysosomal proteases in endocytic and autophagic pathways☆

T. Reinheckel, J. Dennemärker, Sabrina Müller, 2011, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics.

Secreted Cysteine Cathepsins – Versatile Players in Extracellular Proteolysis

T. Reinheckel, K. Sachse, F. Werner, 2012 .

Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation

T. Reinheckel, M. Jäättelä, B. Loos, 2020, Nature Communications.

Degradation of oxidized proteins in mammalian cells

T. Reinheckel, K. Davies, T. Grune, 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Endoscopic treatment of clinically symptomatic leaks of thoracic esophageal anastomoses.

T. Reinheckel, H. Lippert, D. Kunz, 2000, Gastrointestinal endoscopy.

Cathepsin B & L Are Not Required for Ebola Virus Replication

T. Reinheckel, H. Feldmann, A. Marzi, 2012, PLoS neglected tropical diseases.

Activation of the Nipah Virus Fusion Protein in MDCK Cells Is Mediated by Cathepsin B within the Endosome-Recycling Compartment

T. Reinheckel, L. Sauerhering, Stephanie Erbar, 2012, Journal of Virology.

Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter

M. Bogyo, C. Peters, T. Reinheckel, 2003, Proceedings of the National Academy of Sciences of the United States of America.

B-Raf deficiency impairs tumor initiation and progression in a murine breast cancer model

C. Peters, T. Reinheckel, S. Braun, 2019, Oncogene.

Impact of proteolysis on cancer stem cell functions.

T. Reinheckel, L. E. Hillebrand, 2019, Biochimie.

A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis

T. Reinheckel, R. Yates, A. Warren, 2017, Journal of Neuroinflammation.

Lysosomal, cytoskeletal, and metabolic alterations in cardiomyopathy of cathepsin L knockout mice

C. Peters, T. Reinheckel, T. Dandekar, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in the triple-negative breast cancer microenvironment

Pitter F. Huesgen, T. Reinheckel, S. Manoir, 2020, Theranostics.

In Vivo Imaging of Antileukemic Drug Asparaginase Reveals a Rapid Macrophage-Mediated Clearance from the Bone Marrow

T. Reinheckel, O. Boerman, D. S. van Ingen Schenau, 2017, The Journal of Nuclear Medicine.

A new model system identifies epidermal growth factor receptor–human epidermal growth factor receptor 2 (HER2) and HER2–human epidermal growth factor receptor 3 heterodimers as potent inducers of oesophageal epithelial cell invasion

A. Walch, A. Buck, T. Reinheckel, 2017, The Journal of pathology.

Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment.

Christoph Peters, Matthew Bogyo, Olga Vasiljeva, 2011, Nature nanotechnology.

Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis

C. Peters, T. Reinheckel, L. Coussens, 2010, Oncogene.

Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient mice

O. Vasiljeva, A. Krüger, H. Brodoefel, 2008, Oncogene.

Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts

T. Reinheckel, O. Schilling, J. Kizhakkedathu, 2011, Biological chemistry.

Stefin B deficiency reduces tumor growth via sensitization of tumor cells to oxidative stress in a breast cancer model

O. Vasiljeva, A. Krüger, C. Peters, 2014, Oncogene.

Cathepsin L is required for endothelial progenitor cell–induced neovascularization

E. Chavakis, L. Pennacchio, C. Peters, 2005, Nature Medicine.

Cystatin M/E Is a High Affinity Inhibitor of Cathepsin V and Cathepsin L by a Reactive Site That Is Distinct from the Legumain-binding Site

T. Reinheckel, J. Schalkwijk, K. Hitomi, 2006, Journal of Biological Chemistry.

Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model

M. Bogyo, C. Peters, T. Reinheckel, 2008, Biological chemistry.

Thyroid functions of mouse cathepsins B, K, and L.

J. Deussing, C. Peters, T. Reinheckel, 2003, The Journal of clinical investigation.

Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L

Christoph Peters, Günter Breithardt, Jörg Stypmann, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Out-of-frame start codons prevent translation of truncated nucleo-cytosolic cathepsin L in vivo

T. Reinheckel, S. Tholen, S. Arnold, 2014, Nature Communications.

Induction of Premalignant Host Responses by Cathepsin X/Z-Deficiency in Helicobacter Pylori-Infected Mice

T. Reinheckel, A. Roessner, D. Kuester, 2013, PloS one.

Differential Oxidative Injury in Extrapancreatic Tissues During Experimental Pancreatitis

T. Reinheckel, H. Lippert, W. Halangk, 2001, Digestive Diseases and Sciences.

Lysosomal protein turnover contributes to the acquisition of TGFβ-1 induced invasive properties of mammary cancer cells

T. Reinheckel, O. Schilling, M. Biniossek, 2015, Molecular Cancer.

Cathepsin C is a tissue-specific regulator of squamous carcinogenesis

Bonnie F. Sloane, T. Reinheckel, L. Coussens, 2013, Genes & development.

Differential Impact of Cysteine Cathepsins on Genetic Mouse Models of De novo Carcinogenesis: Cathepsin B as Emerging Therapeutic Target

O. Vasiljeva, A. Krüger, C. Peters, 2012, Front. Pharmacol..

The role of proteases in epithelial-to-mesenchymal cell transitions in cancer

T. Reinheckel, U. Burk, J. Mitschke, 2019, Cancer and Metastasis Reviews.

A new model system identifies EGFR/HER2 and HER2/HER3 heterodimers as potent inducers of oesophageal epithelial cell invasion

A. Walch, A. Buck, T. Reinheckel, 2017 .

Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis

T. Reinheckel, J. Slotta-Huspenina, T. Greten, 2018, Cell.

Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling

C. Peters, T. Reinheckel, M. Boerries, 2020, Nature Communications.

The secreted inhibitor of invasive cell growth CREG1 is negatively regulated by cathepsin proteases

C. Peters, T. Reinheckel, O. Schilling, 2020, Cellular and Molecular Life Sciences.

Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis

T. Reinheckel, A. Prescott, V. Poli, 2018, Nature Communications.

University of Dundee Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT 3-dependent pathway of lysosomal homeostasis

T. Reinheckel, A. Prescott, V. Poli, 2018 .

The PI3K regulatory subunits p55α and p50α regulate cell death in vivo

T. Reinheckel, C. Kahn, C. Watson, 2014, Cell Death and Differentiation.

A Transporter Associated with Antigen-Processing Independent Vacuolar Pathway for the MHC Class I-Mediated Presentation of Endogenous Transmembrane Proteins

T. Reinheckel, F. Momburg, G. Hämmerling, 2007, The Journal of Immunology.

Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis

T. Reinheckel, A. Prescott, V. Poli, 2018, Nature Communications.

Tyrosine kinase inhibitors trigger lysosomal damage-associated cell lysis to activate the NLRP3 inflammasome

T. Reinheckel, R. Backofen, C. Parker, 2022, bioRxiv.

carcinogenesis Cathepsin C is a tissue-specific regulator of squamous Material

Bonnie F. Sloane, T. Reinheckel, L. Coussens, 2013 .

Tissue inhibitor of metalloproteinases (TIMP)‐1 creates a premetastatic niche in the liver through SDF‐1/CXCR4‐dependent neutrophil recruitment in mice

A. Krüger, T. Reinheckel, M. Heikenwalder, 2015, Hepatology.

Emerging roles of cysteine cathepsins in disease and their potential as drug targets.

O. Vasiljeva, C. Peters, T. Reinheckel, 2007, Current pharmaceutical design.

Lysosome-Dependent Activation of Human Dendritic Cells by the Vaccine Adjuvant QS-21

T. Reinheckel, P. Courtoy, Abdelatif Elouahabi, 2017, Front. Immunol..

Proteolysis-a characteristic of tumor-initiating cells in murine metastatic breast cancer

T. Reinheckel, M. Boerries, H. Busch, 2016, Oncotarget.

Cathepsin D is one of the major enzymes involved in intracellular degradation of AGE-modified proteins

T. Reinheckel, N. Breusing, T. Grune, 2010, Free radical research.

Proteasome-dependent turnover of protein disulfide isomerase in oxidatively stressed cells.

T. Reinheckel, K. Davies, T. Grune, 2002, Archives of biochemistry and biophysics.

Profiling Trait Anxiety: Transcriptome Analysis Reveals Cathepsin B (Ctsb) as a Novel Candidate Gene for Emotionality in Mice

F. Holsboer, J. Deussing, C. Peters, 2011, PloS one.

Conditional Gene Targeting Reveals Cell Type-Specific Roles of the Lysosomal Protease Cathepsin L in Mammary Tumor Progression

T. Reinheckel, A. Jacquel, Manuel Schlimpert, 2020, Cancers.

Cathepsin B as a potential cystatin M/E target in the mouse hair follicle

T. Reinheckel, F. Kersten, S. Verbeek, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Individual nephron proteomes connect morphology and function in proteinuric kidney disease

Markus M. Rinschen, T. Reinheckel, A. Beyer, 2017, bioRxiv.

Cathepsin G in Experimental Tuberculosis: Relevance for Antibacterial Protection and Potential for Immunotherapy

T. Reinheckel, S. Ehlers, U. Maus, 2015, The Journal of Immunology.

This information is current as Potential for Immunotherapy Relevance for Antibacterial Protection and Cathepsin G in Experimental Tuberculosis :

T. Reinheckel, S. Ehlers, U. Maus, 2015 .

Neuronal-specific microexon splicing of TAF1 mRNA is directly regulated by SRRM4/nSR100

B. Blencowe, A. Graybiel, M. Creyghton, 2019, RNA biology.

Mutations in LRPAP1 are associated with severe myopia in humans.

T. Reinheckel, F. Alkuraya, S. Anazi, 2013, American journal of human genetics.

A role for cathepsin E in the processing of mast-cell carboxypeptidase A

C. Peters, T. Reinheckel, P. Saftig, 2005, Journal of Cell Science.

Molecular Characterization of Arylsulfatase G

T. Dierks, T. Reinheckel, M. Damme, 2014, The Journal of Biological Chemistry.

Professor Walter Halangk - Obituary

T. Reinheckel, M. Lerch, M. Löhr, 2018, Pancreatology.

Low‐level lysosomal membrane permeabilization for limited release and sublethal functions of cathepsin proteases in the cytosol and nucleus

T. Reinheckel, Martina Tholen, 2022, FEBS open bio.

The activity and localization patterns of cathepsins B and X in cells of the mouse gastrointestinal tract differ along its length

C. Peters, T. Reinheckel, Tripti Tamhane, 2014, Biological chemistry.

On the road to inflammation: Linking lysosome disruption, lysosomal protease release and necrotic death of immune cells

T. Reinheckel, 2013, Cell cycle.

CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients

P. Poulsen, A. Vaag, T. Reinheckel, 2014, Proceedings of the National Academy of Sciences.

Analyzing the Role of Proteases in Breast Cancer Progression and Metastasis Using Primary Cells from Transgenic Oncomice.

O. Vasiljeva, T. Reinheckel, L. Sevenich, 2021, Methods in molecular biology.

Tumor cell- and microenvironment-specific roles of cysteine cathepsins in mouse models of human cancers.

T. Reinheckel, Lena Hölzen, M. A. Parigiani, 2020, Biochimica et biophysica acta. Proteins and proteomics.

Impact of cathepsin B on the interstitial fluid proteome of murine breast cancers.

C. Peters, T. Reinheckel, O. Schilling, 2016, Biochimie.

Combinatorial Omics Analysis Reveals Perturbed Lysosomal Homeostasis in Collagen VII-deficient Keratinocytes*

T. Reinheckel, R. Backofen, J. Dengjel, 2018, Molecular & Cellular Proteomics.

Cathepsin H deficiency decreases hypoxia-ischemia-induced hippocampal atrophy in neonatal mice through attenuated TLR3/IFN-β signaling

H. Nakanishi, T. Reinheckel, V. Turk, 2021, Journal of Neuroinflammation.

Cathepsin proteases promote angiogenic sprouting and laser-induced choroidal neovascularisation in mice.

T. Reinheckel, D. Boehringer, S. Fauser, 2013, Experimental eye research.

Intracellular cathepsin C levels determine sensitivity of cells to leucyl‐leucine methyl ester‐triggered apoptosis

T. Reinheckel, B. Turk, Barbara Sobotič, 2020, The FEBS journal.

Lysosomal protein turnover contributes to the acquisition of TGFβ-1 induced invasive properties of mammary cancer cells

T. Reinheckel, O. Schilling, M. Biniossek, 2015, Molecular Cancer.

Asparaginyl Endopeptidase (Legumain) Supports Human Th1 Induction via Cathepsin L-Mediated Intracellular C3 Activation

T. Reinheckel, M. Kolev, C. Watts, 2018, Front. Immunol..

Cellular senescence induced by cathepsin X downregulation.

T. Reinheckel, M. Jochum, D. K. Nägler, 2011, European journal of cell biology.

Allergic Airway Inflammation in Mice Deficient for the Antigen-Processing Protease Cathepsin E

T. Reinheckel, T. Welte, D. Groneberg, 2012, International Archives of Allergy and Immunology.

Murine and human cathepsin B exhibit similar properties: possible implications for drug discovery

Thomas Reinheckel, T. Reinheckel, V. Turk, 2009, Biological chemistry.

A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis

T. Reinheckel, R. Yates, Dale R. Balce, 2017, Journal of Neuroinflammation.

Cathepsin X-deficient Gastric Epithelial Cells in Co-culture with Macrophages

T. Reinheckel, A. Roessner, D. Kuester, 2010, The Journal of Biological Chemistry.

Unimpeded skin carcinogenesis in K14‐HPV16 transgenic mice deficient for plasminogen activator inhibitor

J. Foidart, A. Noël, P. Delvenne, 2011, International journal of cancer.

Legumain is activated in macrophages during pancreatitis.

M. Bogyo, T. Reinheckel, P. Storz, 2016, American journal of physiology. Gastrointestinal and liver physiology.

Towards Specific Functions of Lysosomal Cysteine Peptidases: Phenotypes of Mice Deficient for Cathepsin Β or Cathepsin L

J. Deussing, C. Peters, T. Reinheckel, 2001 .

Proteolysis in Cultured Liver Epithelial Cells during Oxidative Stress

T. Reinheckel, K. Davies, T. Grune, 1995, The Journal of Biological Chemistry.

Cathepsin B-deficient mice as source of monoclonal anti-cathepsin B antibodies

Bonnie F. Sloane, T. Reinheckel, K. Moin, 2015, Biological chemistry.

Cysteine-type cathepsins promote the effector phase of acute cutaneous delayed-type hypersensitivity reactions

T. Reinheckel, M. Gütschow, S. Laufer, 2019, Theranostics.

Ezrin turnover and cell shape changes catalyzed by proteasome in oxidatively stressed cells

T. Reinheckel, K. Davies, T. Grune, 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice.

O. Vasiljeva, J. Deussing, C. Peters, 2010, Proceedings of the National Academy of Sciences of the United States of America.