H. Klein

发表

Bioessays news and reviews in molecular, cellular and developmental biology

J. Klein, M. Fasshauer, H. Klein, 2002 .

Functional characteristics of insulin receptors with a Thr!Ser 1200 mutation overexpressed in Chinese hamster

H. Klein, H. Benecke, Experimental S Tudy, 2000 .

Functional characteristics of insulin receptors with a Thr-->Ser1200 mutation overexpressed in Chinese hamster ovary cells.

H. Klein, H. Benecke, M. Drenckhan, 2000, European journal of endocrinology.

Serine residues 994 and 1023/25 are important for insulin receptor kinase inhibition by protein kinase C isoforms β2 and θ

H. Klein, J. Krützfeldt, H. Häring, 2000, Diabetologia.

Elevation of Serum Insulin Concentration During Euglycemic Hyperinsulinemic Clamp Studies Leads to Similar Activation of Insulin Receptor Kinase in Skeletal Muscle of Subjects With and Without NIDDM

H. Klein, H. Vestergaard, O. Pedersen, 1995, Diabetes.

Metformin inhibits leptin secretion via a mitogen-activated protein kinase signalling pathway in brown adipocytes.

J. Klein, M. Fasshauer, H. Klein, 2004, The Journal of endocrinology.

Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects.

H. Klein, J. Olefsky, R. Henry, 1987, The Journal of clinical investigation.

Insulin receptor kinase activity in rat liver. Regulation by fasting and high carbohydrate feeding.

H. Klein, J. Olefsky, R. Cordera, 1985, The Journal of biological chemistry.

Severe insulin-resistant diabetes mellitus in patients with congenital muscle fiber type disproportion myopathy.

T. Hansen, H. Klein, H. Vestergaard, 1995, The Journal of clinical investigation.

Simvastatin Acutely Reduces Myocardial Reperfusion Injury In Vivo by Activating the Phosphatidylinositide 3-Kinase/Akt Pathway

H. Klein, G. Richardt, S. Wolfrum, 2004, Journal of cardiovascular pharmacology.

Calpain inhibition impairs glycogen syntheses in HepG2 hepatoma cells without altering insulin signaling.

H. Klein, M. Drenckhan, M. Schütt, 2007, The Journal of endocrinology.

Troglitazone treatment increases protein kinase B phosphorylation in skeletal muscle of normoglycemic subjects at risk for the development of type 2 diabetes.

H. Klein, H. Beck-Nielsen, K. Levin, 2002, Diabetes.

Functional and structural differences in human and rat-derived insulin receptors: characterization of the beta-subunit kinase activity.

H. Klein, J. Olefsky, R. Henry, 1988, Endocrinology.

Novel adipocyte lines from brown fat: a model system for the study of differentiation, energy metabolism, and insulin action.

M. Fasshauer, H. Klein, M. Benito, 2002, BioEssays : news and reviews in molecular, cellular and developmental biology.

Insulin signalling in skeletal muscle of subjects with or without Type II-diabetes and first degree relatives of patients with the disease

H. Klein, H. Beck-Nielsen, K. Levin, 2002, Diabetologia.

Ramipril increases the protein level of skeletal muscle IRS-1 and alters protein tyrosine phosphatase activity in spontaneously hypertensive rats

H. Klein, J. Krützfeldt, W. Raasch, 2000, Naunyn-Schmiedeberg's Archives of Pharmacology.

A Microtiter Well Assay System to Measure Insulin Activation of Insulin Receptor Kinase in Intact Human Mononuclear Cells: Decreased Insulin Effect in Cells From Patients With NIDDM

H. Klein, M. Drenckhan, S. Matthaei, 1993, Diabetes.

Serum leptin concentrations throughout the menstrual cycle

H. Klein, O. Ortmann, K. Diedrich, 2000, Archives of Gynecology and Obstetrics.

Delays in insulin signaling towards glucose disposal in human skeletal muscle.

H. Klein, H. Beck-Nielsen, K. Levin, 2002, The Journal of endocrinology.

Regulation of Glucose-6-Phosphatase Gene Expression by Insulin and Metformin

H. Klein, S. Bornstein, L. Klotz, 2009, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Sustained signalling from the insulin receptor after stimulation with insulin analogues exhibiting increased mitogenic potency.

H. Klein, B. Hansen, G. Danielsen, 1996, The Biochemical journal.

Leptin secretion and negative autocrine crosstalk with insulin in brown adipocytes.

J. Klein, M. Fasshauer, H. Klein, 2002, The Journal of endocrinology.

Direct effects of ciliary neurotrophic factor on brown adipocytes: evidence for a role in peripheral regulation of energy homeostasis.

J. Klein, H. Klein, M. Fasshauer, 2002, The Journal of endocrinology.

The relationship between insulin binding, insulin activation of insulin-receptor tyrosine kinase, and insulin stimulation of glucose uptake in isolated rat adipocytes. Effects of isoprenaline.

H. Klein, S. Matthaei, P. Scriba, 1991, The Biochemical journal.

Implications of compound heterozygous insulin receptor mutations in congenital muscle fibre type disproportion myopathy for the receptor kinase activation

H. Klein, H. Vestergaard, O. Pedersen, 1999, Diabetologia.

Adenosine modulates insulin activation of insulin receptor kinase in intact rat adipocytes.

H. Klein, J. Olefsky, T. Ciaraldi, 1987, Endocrinology.

Insulin activation of insulin receptor kinase in erythrocytes is not altered in non-insulin-dependent diabetes and not influenced by hyperglycemia.

H. Klein, M. Drenckhan, M. Schütt, 2000, The Journal of endocrinology.

Treatment of patients with human insulin

H. Klein, M. Kiln, 1996, Diabetologia.

Insulin activation of insulin receptor tyrosine kinase in intact rat adipocytes. An in vitro system to measure histone kinase activity of insulin receptors activated in vivo.

H. Klein, J. Olefsky, M. Kladde, 1986, The Journal of biological chemistry.

Atypical β-adrenergic effects on insulin signaling and action in β3-adrenoceptor-deficient brown adipocytes

J. Klein, M. Fasshauer, H. Klein, 2002 .

Direct peripheral effects of ghrelin include suppression of adiponectin expression.

J. Klein, M. Fasshauer, H. Klein, 2002, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Insulin-mimetic actions of phorbol ester in cultured adult rat hepatocytes. Lack of phorbol-ester-elicited inhibition of the insulin signal.

H. Klein, A. Quentmeier, I. Probst, 1993, The Biochemical journal.

Attenuation of insulin actions in primary rat hepatocyte cultures by phenylarsine oxide.

H. Klein, A. Quentmeier, I. Probst, 1993, Biological chemistry Hoppe-Seyler.

Microtiter well assays for protein tyrosine phosphatase activities directed against phosphorylated insulin receptor or insulin receptor substrate-1.

H. Klein, J. Krützfeldt, M. Drenckhan, 1999, Analytical biochemistry.

The beta3-adrenergic agonist CL316,243 inhibits insulin signaling but not glucose uptake in primary human adipocytes.

J. Klein, H. Klein, M. Jost, 2005, Experimental and clinical endocrinology & diabetes.

Regulation of epidermal growth factor receptor number and phosphorylation by fasting in rat liver.

H. Klein, J. Olefsky, M. Kladde, 1986, The Journal of biological chemistry.

Muscle-Specific Expression of Human Insulin Receptor in Transgenic Mice

H. Klein, K. Siddle, J. Flier, 1993, Diabetes.

Effect of in vivo thyroid hormone status on insulin signalling and GLUT1 and GLUT4 glucose transport systems in rat adipocytes.

H. Klein, H. Benecke, A. Hamann, 1995, The Journal of endocrinology.

Substrate specificities of insulin and epidermal growth factor receptor kinases.

H. Klein, J. Olefsky, R. Cordera, 1985, Biochemical and biophysical research communications.

Differential modulation of insulin actions by dexamethasone: studies in primary cultures of adult rat hepatocytes.

H. Klein, M. Drenckhan, I. Probst, 2002, Journal of hepatology.

Association of Metformin's Effect to Increase Insulin-Stimulated Glucose Transport With Potentiation of Insulin-Induced Translocation of Glucose Transporters From Intracellular Pool to Plasma Membrane in Rat Adipocytes

H. Klein, J. Flier, H. Benecke, 1991, Diabetes.

The proteomic signature of insulin-resistant human skeletal muscle reveals increased glycolytic and decreased mitochondrial enzymes

J. W. Dietrich, Johannes W. Dietrich, H. Klein, 2012, Diabetologia.

Serine residues 994 and 1023/25 are important for insulin receptor kinase inhibition by protein kinase C isoforms beta2 and theta.

H. Klein, J. Krützfeldt, H. Häring, 2000, Diabetologia.

Serine residues 1177/78/82 of the insulin receptor are required for substrate phosphorylation but not autophosphorylation.

A. Ullrich, H. Klein, J. Krützfeldt, 2000, Diabetes.

In vivo metformin treatment ameliorates insulin resistance: evidence for potentiation of insulin-induced translocation and increased functional activity of glucose transporters in obese (fa/fa) Zucker rat adipocytes.

H. Klein, H. Benecke, H. Häring, 1993, Endocrinology.

Binding of human, porcine and bovine insulin to insulin receptors from human brain, muscle and adipocytes and to expressed recombinant alternatively spliced insulin receptor isoforms

H. Klein, U. Missler, D. Moller, 1995, Diabetologia.

Insulin signaling and action in cultured skeletal muscle cells from lean healthy humans with high and low insulin sensitivity.

H. Klein, J. Krützfeldt, M. Stumvoll, 2000, Diabetes.

Hypergravity stimulates collagen synthesis in human osteoblast-like cells: evidence for the involvement of p44/42 MAP-kinases (ERK 1/2).

H. Klein, J. Brinckmann, H. Notbohm, 1999, Journal of biochemistry.

Insulin receptor kinase following internalization in isolated rat adipocytes.

H. Klein, J. Olefsky, S. Matthaei, 1987, The Journal of biological chemistry.

The relationship between insulin binding, insulin activation of insulin-receptor tyrosine kinase, and insulin stimulation of glucose uptake in isolated rat adipocytes

H. Klein, S. Matthaei, P. Scriba, 1991 .

Insulin stimulation of human adipocytes activates the kinase of only a fraction of the insulin receptors.

H. Klein, M. Drenckhan, H. Fehm, 1997, American Journal of Physiology.

Evidence that metformin increases insulin-stimulated glucose transport by potentiating insulin-induced translocation of glucose transporters from an intracellular pool to the cell surface in rat adipocytes.

H. Klein, J. Flier, H. Benecke, 1992, Hormone and metabolic research. Supplement series.