M. Benito

M. Benito, Á. Valverde, A. Álvarez, 1996, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Regulation of carnitine palmitoyltransferase activity in the liver and brown adipose tissue in the newborn rat: effect of starvation and hypothermia.

M. Benito, M. Peñas, 1986, Biochemical and biophysical research communications.

Epidermal growth factor, but not hepatocyte growth factor, suppresses the apoptosis induced by transforming growth factor‐beta in fetal hepatocytes in primary culture

M. Benito, I. Fabregat, A. Álvarez, 1996, FEBS letters.

cAMP inhibits IGF-I-induced mitogenesis in fetal rat brown adipocytes: role of p21 ras.

M. Benito, Á. Valverde, M. Lorenzo, 1995, Experimental cell research.

Overexpression of SPARC protein contrasts with its transcriptional silencing by aberrant hypermethylation of SPARC CpG-rich region in endometrial carcinoma.

M. Benito, J. L. Garcia-Asenjo, T. Caldés, 2007, Oncology reports.

Epidermal growth factor impairs the cytochrome C/caspase-3 apoptotic pathway induced by transforming growth factor beta in rat fetal hepatocytes via a phosphoinositide 3-kinase-dependent pathway.

M. Benito, Á. Valverde, I. Fabregat, 2000, Hepatology.

Osteoporosis Remission and New Bone Formation with Mesoporous Silica Nanoparticles

M. Benito, M. Vallet‐Regí, F. Mulero, 2021, Advanced science.

Reactive oxygen species (ROS) mediates the mitochondrial‐dependent apoptosis induced by transforming growth factor ß in fetal hepatocytes

M. Benito, I. Fabregat, A. Álvarez, 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Insulin Resistance and Diabetes Mellitus in Alzheimer’s Disease

M. Benito, C. Guillén, J. Burillo, 2021, Cells.

Chronic Exercise Improves Mitochondrial Function and Insulin Sensitivity in Brown Adipose Tissue

M. Benito, Ó. Escribano, M. Hribal, 2018, Front. Physiol..

mTORC1 Overactivation as a Key Aging Factor in the Progression to Type 2 Diabetes Mellitus

M. Benito, C. Guillén, 2018, Front. Endocrinol..

MMP-7 and SGCE as distinctive molecular factors in sporadic colorectal cancers from the mutator phenotype pathway.

Eduardo Diaz-Rubio, Manuel Benito, M. Benito, 2010, International journal of oncology.

Differential colorectal carcinogenesis: Molecular basis and clinical relevance.

Manuel Benito, M. Benito, A. Torres, 2010, World journal of gastrointestinal oncology.

Molecular biology in colorectal cancer

M. Benito, E. Díaz-Rubio, 2006, Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico.

Differential prognosis of replication error phenotype and loss of heterozygosity in sporadic colorectal cancer.

M. Benito, J. Cerdán, J. Balibrea, 1999, European journal of cancer.

p53 exon 7 mutations as a predictor of poor prognosis in patients with colorectal cancer.

M. Benito, J. Balibrea, A. Torres, 1998, Cancer letters.

Genetic abnormalities and microsatellite instability in colorectal cancer.

M. Benito, C. Fernández, J. Balibrea, 1998, Cancer detection and prevention.

Sirtuins in mechanistic target of rapamycin complex 1 signaling

M. Benito, C. Guillén, J. Burillo, 2021 .

Initial expression of phosphoenolpyruvate carboxykinase gene in fetal hepatocytes: role of transcription factors.

M. Benito, Á. Valverde, M. Lorenzo, 1996, Journal of hepatology.

Regulation of malic enzyme gene expression by nutrients, hormones, and growth factors in fetal hepatocyte primary cultures

M. Benito, M. Lorenzo, C. Molero, 1993, Journal of cellular physiology.

Susceptibility to apoptosis in insulin-like growth factor-I receptor-deficient brown adipocytes.

M. Benito, Á. Valverde, M. Brownlee, 2004, Molecular biology of the cell.

Epidermal Growth Factor Impairs the Cytochrome C/Caspase‐3 Apoptotic Pathway Induced by Transforming Growth Factor β in Rat Fetal Hepatocytes Via a Phosphoinositide 3‐Kinase–Dependent Pathway

M. Benito, Á. Valverde, I. Fabregat, 2000 .

Apoptosis induced by transforming growth factor-beta in fetal hepatocyte primary cultures: involvement of reactive oxygen intermediates.

M. Benito, I. Fabregat, A. Álvarez, 1996, The Journal of biological chemistry.

Transforming growth factor-beta activates both pro-apoptotic and survival signals in fetal rat hepatocytes.

M. Benito, Á. Valverde, I. Fabregat, 2004, Experimental cell research.

Telomere function in colorectal cancer.

M. Benito, A. Torres, E. Díaz-Rubio, 2009, World journal of gastrointestinal oncology.

Apoptotic response to TGF-beta in fetal hepatocytes depends upon their state of differentiation.

M. Benito, I. Fabregat, A. Álvarez, 1999, Experimental cell research.

Methylation profiling in non-small cell lung cancer: clinical implications.

M. Benito, A. Gómez, A. Torres, 2011, International journal of oncology.

Regulation of gene expression by interleukin‐6 in fetal rat hepatocyte primary cultures: Role of epidermal growth factor and dexamethasone

M. Benito, I. Fabregat, C. Roncero, 1995, Hepatology.

Glucose-6-phosphate dehydrogenase gene expression in fetal hepatocyte primary cultures under nonproliferative and proliferative conditions.

M. Benito, M. Lorenzo, C. Molero, 1994, Experimental cell research.

Potential role of insulin receptor isoforms and IGF receptors in plaque instability of human and experimental atherosclerosis

M. Benito, G. Sesti, S. Fernández, 2018, Cardiovascular Diabetology.

Differential Expression of Senescence and Cell Death Factors in Non-Small Cell Lung and Colorectal Tumors Showing Telomere Attrition

M. Benito, A. Gómez, A. Torres, 2012, Oncology.

C3G down-regulates p38 MAPK activity in response to stress by Rap-1 independent mechanisms: involvement in cell death.

Carmen Guerrero, Manuel Benito, M. Benito, 2010, Cellular signalling.

Contribution of brown fat to the neonatal thermogenesis.

M. Benito, 1985, Biology of the neonate.

Prevalence of germline mutations of MLH1 and MSH2 in hereditary nonpolyposis colorectal cancer families from Spain

M. Benito, J. Godino, C. Eng, 2002, International journal of cancer.

Liver-specific insulin receptor isoform A expression enhances hepatic glucose uptake and ameliorates liver steatosis in a mouse model of diet-induced obesity

M. Benito, S. Fernández, Á. González-Rodríguez, 2019, Disease Models & Mechanisms.

p53 exon 5 mutations as a prognostic indicator of shortened survival in non-small-cell lung cancer.

M. Benito, J. Balibrea, A. Torres, 1997, British Journal of Cancer.

Telomere shortening is associated with poor prognosis and telomerase activity correlates with DNA repair impairment in non-small cell lung cancer.

Manuel Benito, M. Benito, A. Gómez, 2008, Lung cancer.

Relationship between 3p deletions and telomerase activity in non-small-cell lung cancer: prognostic implications

M. Benito, J. Balibrea, A. Torres, 2004, British Journal of Cancer.

Differential role of PPAR gamma in the regulation of UCP-1 and adipogenesis by TNF-alpha in brown adipocytes.

M. Benito, A. Porras, A. Valladares, 2002, FEBS Letters.

Cooperative role of telomerase activity and p16 expression in the prognosis of non-small-cell lung cancer.

M. Benito, J. Balibrea, A. Torres, 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Detection of telomerase activity in human carcinomas using a trap-ELISA method: correlation with hTR and hTERT expression.

M. Benito, J. Balibrea, A. Torres, 2000, International journal of oncology.

Role of insulin receptor and the balance in the insulin receptor isoforms A and B in the regulation of apoptosis in SV 40-immortalized neonatal hepatocytes

M. Benito, Á. Valverde, C. Nevado, 2007 .

Activation of p38MAPK by TGF‐β in fetal rat hepatocytes requires radical oxygen production, but is dispensable for cell death

M. Benito, A. Porras, I. Fabregat, 2001, FEBS letters.

DNA amplification on chromosome 6p12 in non small cell lung cancer detected by arbitrarily primed polymerase chain reaction

M. Benito, J. Balibrea, A. Torres, 1999, International journal of cancer.

Stromelysin-1 promoter mutations impair gelatinase B activation in high microsatellite instability sporadic colorectal tumors.

M. Benito, J. Balibrea, S. Ramón y. Cajal, 2002, Cancer research.

Biological and clinical significance of MMP-2, MMP-9, TIMP-1 and TIMP-2 in non-small cell lung cancer.

M. Benito, A. Díaz-López, J. Balibrea, 2007, Oncology reports.

Cellular Models for the Study of Type 2 Diabetes

M. Benito, Á. Valverde, M. Lorenzo, 2005 .

Differential proliferative response of cultured fetal and regenerating hepatocytes to growth factors and hormones.

M. Benito, I. Fabregat, A. Álvarez, 1992, Experimental cell research.

Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance.

M. Benito, C. Kahn, Á. Valverde, 2001, The Journal of clinical investigation.

Long-term treatment with insulin induces apoptosis in brown adipocytes: role of oxidative stress.

Manuel Benito, M. Benito, A. Porras, 2003, Endocrinology.

Overexpression of c-myc and loss of heterozygosity on 2p, 3p, 5q, 17p and 18q in sporadic colorectal carcinoma.

M. Benito, J. Balibrea, A. Torres, 2005, Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva.

Genomic organization of a novel glycosylphosphatidylinositol MAM gene expressed in human tissues and tumors

M. Benito, J. Balibrea, A. Torres, 2002, Oncogene.

Expression of insulin receptor (IR) A and B isoforms, IGF-IR, and IR/IGF-IR hybrid receptors in vascular smooth muscle cells and their role in cell migration in atherosclerosis

M. Benito, J. Michel, S. Fernández, 2016, Cardiovascular Diabetology.

Implication of insulin receptor A isoform and IRA/IGF-IR hybrid receptors in the aortic vascular smooth muscle cell proliferation: role of TNF-α and IGF-II.

M. Benito, S. Fernández, Ó. Escribano, 2013, Endocrinology.

Tissue specificity on insulin action and resistance: past to recent mechanisms

M. Benito, 2011, Acta physiologica.

Development of the uncoupling protein in the rat brown-adipose tissue during the perinatal period. Its relationship with the mitochondrial GDP-binding and GDP-sensitive ion permeabilities and respiration.

M. Benito, A. Porras, Margarita Fernández, 1990, European journal of biochemistry.

The brown adipose cell: a unique model for understanding the molecular mechanism of insulin resistance.

M. Benito, Á. Valverde, 2005, Mini reviews in medicinal chemistry.

Clinical relevance of MMP-9, MMP-2, TIMP-1 and TIMP-2 in colorectal cancer.

M. Benito, A. Díaz-López, J. Balibrea, 2005, Oncology reports.

Activation of Ras by insulin in 3T3 L1 cells does not involve GTPase-activating protein phosphorylation.

M. Benito, A. Porras, A. Nebreda, 1992, The Journal of biological chemistry.

TNF‐α induces apoptosis in rat fetal brown adipocytes in primary culture

M. Benito, A. Porras, A. Valladares, 1997 .

Ras proteins mediate induction of uncoupling protein, IGF-I, and IGF-I receptor in rat fetal brown adipocyte cell lines.

M. Benito, A. Porras, E. Hernández, 1996, DNA and cell biology.

The brown adipose cell: a model for understanding the molecular mechanisms of insulin resistance.

M. Benito, Á. Valverde, M. Lorenzo, 2005, Acta physiologica Scandinavica.

Antagonistic effect of TNF-alpha and insulin on uncoupling protein 2 (UCP-2) expression and vascular damage

M. Benito, Ó. Escribano, Y. Otero, 2014, Cardiovascular Diabetology.

Glucocorticoid receptor down‐Regulates c‐jun amino terminal kinases induced by tumor necrosis factor α in fetal rat hepatocyte primary cultures

M. Benito, I. Fabregat, C. Roncero, 1999, Hepatology.

Adrenergic regulation of the uncoupling protein expression in foetal rat brown adipocytes in primary culture.

M. Benito, A. Porras, M. Fernández, 1989, Biochemical and biophysical research communications.

Effect of postnatal hypoxia on the energy homeostasis of the newborn rat during the early neonatal period.

M. Benito, J. Medina, C. Arizmendi, 1983, Biology of the neonate.

Severe Hepatic Insulin Resistance Induces Vascular Dysfunction: Improvement by Liver-Specific Insulin Receptor Isoform A Gene Therapy in a Murine Diabetic Model

M. Benito, Ó. Escribano, N. de Las Heras, 2021, Cells.

Prognostic value of genomic damage in non-small-cell lung cancer.

M. Benito, C. Fernández, J. Balibrea, 1998, British Journal of Cancer.

MTORC1 Regulates both General Autophagy and Mitophagy Induction after Oxidative Phosphorylation Uncoupling

Y. Kido, M. Benito, U. Pajvani, 2017, Molecular and Cellular Biology.

Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes.

M. Benito, Á. Valverde, Á. González-Rodríguez, 2007, Endocrinology.

PTP1B deficiency increases glucose uptake in neonatal hepatocytes: involvement of IRA/GLUT2 complexes.

M. Benito, Á. Valverde, G. Sesti, 2008, American journal of physiology. Gastrointestinal and liver physiology.

Abbreviated title: Glucose uptake in PTP1B -/- neonatal hepatocytes

A. Sols, M. Benito, Á. Valverde, 2008 .

PTP 1 B deficiency increases glucose uptake in neonatal hepatocytes : involvement of IRA / GLUT 2 complexes

M. Benito, Á. Valverde, G. Sesti, 2008 .

Brown fat lipoatrophy and increased visceral adiposity through a concerted adipocytokines overexpression induces vascular insulin resistance and dysfunction.

M. Benito, Ó. Escribano, Y. Otero, 2012, Endocrinology.

Comparative Survival Analysis of p53 Gene Mutations and Protein Accumulation in Colorectal Cancer

M. Benito, J. Cerdán, C. Fernández, 1998, Oncology.

Association of K-ras codon 12 transversions with short survival in non-small cell lung cancer.

M. Benito, J. Balibrea, A. Torres, 1996, International journal of oncology.

Insulin receptor isoform A ameliorates long-term glucose intolerance in diabetic mice

M. Benito, P. Chambon, S. Fernández, 2016, Disease Models & Mechanisms.

The role of prolactin and progesterone in the regulation of lipogenesis in maternal and foetal rat liver in vivo and in isolated hepatocytes during the last day of gestation.

M. Benito, M. Lorenzo, C. Roncero, 1986, The Biochemical journal.

Triiodothyronine induces the expression of the uncoupling protein in long term fetal rat brown adipocyte primary cultures: role of nuclear thyroid hormone receptor expression.

M. Benito, A. Porras, C. Roncero, 1994, Endocrinology.

Phosphoenolpyruvate carboxykinase and glucose-6-phosphate dehydrogenase expression in fetal hepatocyte primary cultures under proliferative conditions.

M. Benito, Á. Valverde, M. Lorenzo, 1992, Experimental cell research.

Pancreatic β cells overexpressing hIAPP impaired mitophagy and unbalanced mitochondrial dynamics

M. Benito, C. Guillén, J. Burillo, 2018, Cell Death & Disease.

Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance.

M. Benito, C. Kahn, Á. Valverde, 2019, The Journal of clinical investigation.

Expression of MMP-9 and TIMP-1 as prognostic markers in gastric carcinoma.

M. Benito, A. Díaz-López, J. Balibrea, 2007, Hepato-gastroenterology.

Hepatocyte growth factor up-regulates met expression in rat fetal hepatocytes in primary culture.

M. Benito, I. Fabregat, A. Sánchez, 1994, Biochemical and biophysical research communications.

Role of insulin receptor and balance in insulin receptor isoforms A and B in regulation of apoptosis in simian virus 40-immortalized neonatal hepatocytes.

M. Benito, Á. Valverde, C. Nevado, 2007, Molecular biology of the cell.

[Role of brown and perivascular adipose tissue in vascular complications due to obesity].

M. Benito, Ó. Escribano, A. Gómez-Hernández, 2013, Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis.

High-resolution genome-wide analysis of chromosomal alterations in elastofibroma

M. Benito, J. Hernández, A. Bullón, 2010, Virchows Archiv.

Insulin and insulin-like growth factor I up-regulate GLUT4 gene expression in fetal brown adipocytes, in a phosphoinositide 3-kinase-dependent manner.

M. Benito, Á. Valverde, P. Navarro, 1999, The Biochemical journal.

Insulin/IGF-I rescues immortalized brown adipocytes from apoptosis down-regulating Bcl-xS expression, in a PI 3-kinase- and map kinase-dependent manner.

M. Benito, Á. Valverde, P. Navarro, 1998, Experimental cell research.

Essential role of glucokinase in the protection of pancreatic β cells to the glucose energetic status

M. Benito, A. Bartolomé, C. Guillén, 2019, Cell Death Discovery.

IGF-I induces the uncoupling protein gene expression in fetal rat brown adipocyte primary cultures: role of C/EBP transcription factors.

M. Benito, M. Fernández, C. Guerra, 1994, Biochemical and biophysical research communications.

Hormonal regulation of rat foetal lipogenesis in brown-adipocyte primary cultures.

M. Benito, I. Fabregat, M. Lorenzo, 1988, The Biochemical journal.