J. Hagan

J. Hagan, F. Ablondi, Frank B. Ablondi, 1957, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Allocentric Spatial Learning by Hippocampectomised Rats: A Further Test of the “Spatial Mapping” and “Working Memory” Theories of Hippocampal Function

R. Morris, J. Rawlins, R. Morris, 1986, The Quarterly journal of experimental psychology. B, Comparative and physiological psychology.

Blockade of spatial learning by the M1 muscarinic antagonist pirenzepine

J. Hagan, C. Broekkamp, J. Jansen, 2004, Psychopharmacology.

Dopamine D3 Receptor Antagonism Inhibits Cocaine-Seeking and Cocaine-Enhanced Brain Reward in Rats

J. Hagan, D. Middlemiss, G. Stemp, 2002, The Journal of Neuroscience.

Lack of task specificity and absence of posttraining effects of atropine on learning.

R. Morris, J. Hagan, F. Tweedie, 1986, Behavioral neuroscience.

Behavioral screening for cognition enhancers: from indiscriminate to valid testing: Part I

P. Dudchenko, J. Hagan, M. Sarter, 2005, Psychopharmacology.

Behavioural and electrophysiological studies of entorhinal cortex lesions in the rat

J. J. Hagan, M. H. Spigt, J. Hagan, 1992, Physiology & Behavior.

Implementation of a large-scale ENU mutagenesis program: towards increasing the mouse mutant resource

Steve D. M. Brown, Steve D.M. Brown, Mark Strivens, 2000, Mammalian Genome.

The effects of central catecholamine depletions on spatial learning in rats

R. Morris, R. Morris, S. Iversen, 1983, Behavioural Brain Research.

Behavioral screening for cognition enhancers: from indiscriminate to valid testing: Part II

P. Dudchenko, J. Hagan, M. Sarter, 2005, Psychopharmacology.

Post-training vasopressin injections may facilitate or delay shuttle-box avoidance extinction.

J. Hagan, B. Bohus, D. de Wied, 1982, Behavioral and neural biology.

Characterisation of the selective 5-HT1B receptor antagonist SB-616234-A (1-[6-(cis-3,5-dimethylpiperazin-1-yl)-2,3-dihydro-5-methoxyindol-1-yl]-1-[2′-methyl-4′-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride): In vivo neurochemical and behavioural evidence of anxiolytic/antidep

J. Hagan, G. W. Price, S. Melotto, 2006, Neuropharmacology.

Pharmacological Assessment of M1 Muscarinic Acetylcholine Receptor-Gq/11 Protein Coupling in Membranes Prepared from Postmortem Human Brain Tissue

C. Davies, J. Hagan, M. Wood, 2008, Journal of Pharmacology and Experimental Therapeutics.

Pharmacological Assessment of M 1 Muscarinic Acetylcholine Receptor-Gq / 11 Protein Coupling in Membranes Prepared from Postmortem Human Brain Tissue

C. Davies, J. Hagan, M. Wood, 2008 .

Parkinson's disease: prospects for improved drug therapy.

J. Hagan, D. Middlemiss, G. Poste, 1997, Trends in pharmacological sciences.

Selective behavioural impairment after acute intoxication with trimethyltin (TMT) in rats.

J. Hagan, C. Broekkamp, J. Jansen, 1988, Neurotoxicology.

The behavioural effects of corticotropin-releasing factor-related peptides in rats

J. Hagan, D. Middlemiss, R. Kortekaas, 1998, Psychopharmacology.

Long-lasting changes in behavioural and neuroendocrine indices in the rat following neonatal maternal separation: Gender-dependent effects

J. Hagan, C. Marsden, H. Slotten, 2006, Brain Research.

Practical and Theoretical Issues in Gene-Targeting Studies and their Application to Behaviour

J. Hagan, D. Rogers, Declan Jones, 2000, Reviews in the neurosciences.

Use of SHIRPA and discriminant analysis to characterise marked differences in the behavioural phenotype of six inbred mouse strains

Jim J. Hagan, J. Hagan, D. Rogers, 1999, Behavioural Brain Research.

Drug repositioning for Alzheimer's disease

Paul Edison, Anne Corbett, Cornelius Katona, 2012, Nature Reviews Drug Discovery.

Selective dopamine D3 receptor antagonist SB‐277011‐A potentiates phMRI response to acute amphetamine challenge in the rat brain

Angelo Bifone, Alessandro Gozzi, Torsten Reese, 2004, Synapse.

The effects of lysine vasopressin on conditioned behaviour in rats.

J. Hagan, 1980 .

Characterization of SB‐269970‐A, a selective 5‐HT7 receptor antagonist

J. Hagan, D. Middlemiss, G. W. Price, 2000, British journal of pharmacology.

Use of Copper-Amino Acid Gomplexing for Determining Amino Acid Esterase Activity.∗

J. Hagan, B. L. Hutchings, F. Ablondi, 1956, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Pharmacological actions of a novel, high-affinity, and selective human dopamine D(3) receptor antagonist, SB-277011-A.

J. Hagan, D. Middlemiss, K. Thewlis, 2000, The Journal of pharmacology and experimental therapeutics.

Behavioural and cognitive abnormalities in an imprinting centre deletion mouse model for Prader–Willi syndrome

L. Wilkinson, T. Humby, J. Hagan, 2010, The European journal of neuroscience.

Orexin A activates locus coeruleus cell firing and increases arousal in the rat.

M. I. Smith, M L Evans, J. Hagan, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Long-term evaluation of isolation-rearing induced prepulse inhibition deficits in rats

J. Hagan, C. Reavill, D. Jones, 2001, Psychopharmacology.

Predicting drug efficacy for cognitive deficits in schizophrenia.

J. Hagan, Declan Jones, 2005, Schizophrenia bulletin.

Increased responsiveness of dopamine to atypical, but not typical antipsychotics in the medial prefrontal cortex of rats reared in isolation

J. Hagan, Alan R. Atkins, Z. Hughes, 2001, Psychopharmacology.

5-HT7 receptors.

J. Hagan, Jim J Hagan, David R. Thomas, 2004, Current drug targets. CNS and neurological disorders.

SB‐656104‐A, a novel selective 5‐HT7 receptor antagonist, modulates REM sleep in rats

J. Hagan, D. Middlemiss, C. Scott, 2003, British journal of pharmacology.

Attenuation of Cue-Controlled Cocaine-Seeking by a Selective D3 Dopamine Receptor Antagonist SB-277011-A

B. Everitt, J. Hagan, P. Ciano, 2003, Neuropsychopharmacology.

Fluoxetine administration modulates the cytoskeletal microtubular system in the rat hippocampus

J. Hagan, M. Hows, C. Marsden, 2009, Synapse.

Isolation rearing induces recognition memory deficits accompanied by cytoskeletal alterations in rat hippocampus

J. Hagan, Norazrina Azmi, C. Marsden, 2006, The European journal of neuroscience.

Comparison of the functional potencies of ropinirole and other dopamine receptor agonists at human D2(long), D3 and D4.4 receptors expressed in Chinese hamster ovary cells

J. Hagan, D. Middlemiss, T. Brown, 1999, British journal of pharmacology.

Localisation of NMU1R and NMU2R in human and rat central nervous system and effects of neuromedin-U following central administration in rats

J. Hagan, H. Sarau, P. Murdock, 2004, Psychopharmacology.

5-HT6 receptor antagonists enhance retention of a water maze task in the rat

J. Hagan, D. Rogers, 2001, Psychopharmacology.

Measurement of arginase activity.

J. Hagan, R. Dallam, 1968, Analytical biochemistry.

Effect of 5-HT1B/D receptor agonist and antagonist administration on motor function in haloperidol and MPTP-treated common marmosets

J. Hagan, P. Jenner, R. Pearce, 2004, Pharmacology Biochemistry and Behavior.

Blockade of mesolimbic dopamine D3 receptors inhibits stress-induced reinstatement of cocaine-seeking in rats

J. Hagan, Z. Xi, C. Heidbreder, 2004, Psychopharmacology.

N-desmethylclozapine (NDMC) is an antagonist at the human native muscarinic M1 receptor

C. Langmead, C. Davies, J. Hagan, 2010, Neuropharmacology.

A comparison of rectal and subcutaneous body temperature measurement in the common marmoset.

J. Hagan, N. Upton, D. Piper, 1998, Journal of pharmacological and toxicological methods.

Spatial learning in the rat: impairment induced by the thiol-proteinase inhibitor, leupeptin, and an analysis of [3H]glutamate receptor binding in relation to learning.

L. Nadel, G. Lynch, R. Morris, 1987, Behavioral and neural biology.

Studies towards the identification of a new generation of atypical antipsychotic agents.

C. Scorer, J. Hagan, I. Forbes, 2007, Bioorganic & medicinal chemistry letters.

The 5-HT6 Receptor Antagonist SB-271046 Reverses Scopolamine-Disrupted Consolidation of a Passive Avoidance Task and Ameliorates Spatial Task Deficits in Aged Rats

K. J. Murphy, J. Hagan, C. Regan, 2004, Neuropsychopharmacology.

5‐HT6 receptor antagonist SB‐271046 enhances extracellular levels of monoamines in the rat medial prefrontal cortex

J. Hagan, C. Heidbreder, L. Lacroix, 2004, Synapse.

Chronic fluoxetine differentially modulates the hippocampal microtubular and serotonergic system in grouped and isolation reared rats

J. Hagan, C. Marsden, Alan R. Atkins, 2009, European Neuropsychopharmacology.

A computer-controlled apparatus for measuring and analysing myoclonic jerk activity in guinea pigs

P. S. Lloyd, P. D. Slade, J. P. Hatcher, 1996, Journal of Neuroscience Methods.

The role of 5-HT1D and 5-HT1A receptors in mediating 5-hydroxytryptophan induced myoclonic jerks in guinea pigs.

J. Hagan, J. Hatcher, P. Slade, 1995, European journal of pharmacology.

In Vitro and In Vivo Characterization of the Non-peptide NK3 Receptor Antagonist SB-223412 (Talnetant): Potential Therapeutic Utility in the Treatment of Schizophrenia

C. Davies, J. Hagan, J. Kew, 2008, Neuropsychopharmacology.

Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone.

C. Langmead, J. Hagan, D. Middlemiss, 2005, European journal of pharmacology.

Functional characterisation of the human cloned 5‐HT7 receptor (long form); antagonist profile of SB‐258719

J. Hagan, D. Middlemiss, I. Forbes, 1998, British journal of pharmacology.

The relative potencies of cholinomimetics and muscarinic antagonists on the rat iris in vivo: effects of pH on potency of pirenzepine and telenzepine

J. Hagan, C. Broekkamp, B. V. D. Heijden, 1988, Naunyn-Schmiedeberg's Archives of Pharmacology.

Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77‐LH‐28‐1

M. Whittington, C. Langmead, C. Davies, 2008, British journal of pharmacology.

Hemicholinium-3 impairs spatial learning and the deficit is reversed by cholinomimetics

J. Hagan, C. Broekkamp, J. Jansen, 2004, Psychopharmacology.

Acute administration of the selective D3 receptor antagonist SB‐277011A blocks the acquisition and expression of the conditioned place preference response to heroin in male rats

J. Hagan, C. Heidbreder, E. Gardner, 2003, Synapse.

Selective Antagonism at Dopamine D3 Receptors Prevents Nicotine-Triggered Relapse to Nicotine-Seeking Behavior

J. Hagan, M. Pilla, C. Heidbreder, 2003, Neuropsychopharmacology.

Acute and chronic administration of the selective D(3) receptor antagonist SB-277011-A alters activity of midbrain dopamine neurons in rats: an in vivo electrophysiological study.

J. Hagan, D. Middlemiss, Y. Minabe, 2000, The Journal of pharmacology and experimental therapeutics.

5-HT 1D receptors mediate SKF 99101H-induced hypothermia in the guinea pig

J. Hagan, C. Roberts, J. Hatcher, 1995, Journal of psychopharmacology.

The effect of SB-236057-A, a selective 5-HT1B receptor inverse agonist, on in vivo extracellular 5-HT levels in the freely-moving guinea-pig

J. Hagan, D. Middlemiss, P. Wyman, 2000, Naunyn-Schmiedeberg's Archives of Pharmacology.

In vitro and in vivo comparison of two non-peptide tachykinin NK3 receptor antagonists: Improvements in efficacy achieved through enhanced brain penetration or altered pharmacological characteristics.

Paul W Smith, C. Langmead, C. Davies, 2010, European journal of pharmacology.

Therapeutic effect of THA on hemicholinium-3-induced learning impairment is independent of serotonergic and noradrenergic systems

J. Hagan, T. Boer, F. Nefkens, 2005, Psychopharmacology.

5-HT7 receptors modulate synchronized network activity in rat hippocampus

C. Davies, J. Hagan, C. Gill, 2002, Neuropharmacology.

Altered M1 Muscarinic Acetylcholine Receptor (CHRM1)-Gαq/11 Coupling in a Schizophrenia Endophenotype

J. Hagan, B. Dean, R. Challiss, 2009, Neuropsychopharmacology.

Effects of lysine vasopressin and response prevention on avoidance responding in extinction.

J. Hagan, 1982, Behavioral and neural biology.

The effects of forebrain ischaemia on spatial learning

J. Hagan, M. Beaughard, 1990, Behavioural Brain Research.

Effects of fluoxetine on social behaviour and plasma corticosteroid levels in female mongolian gerbils

J. Hagan, C. Hendrie, M. Duxon, 2003, Behavioural pharmacology.

Molecular and Functional Models in Neuropsychiatry

J. Hagan, 2011 .

Cholinergic stimulation of drinking from the lateral hypothalamus: Indications for M2 muscarinic receptor mediation

J. Hagan, C. Broekkamp, J. Tonnaer, 1987, Pharmacology Biochemistry and Behavior.

Place navigation in rats is impaired by lesions of medial septum and diagonal band but not nucleus basalis magnocellularis

R. Morris, S. Iversen, J. Salamone, 1988, Behavioural Brain Research.

Evaluation of the spontaneously hypertensive rat as a model of attention deficit hyperactivity disorder: acquisition and performance of the DRL-60s test

J. Hagan, C. Reavill, Jim J Hagan, 2000, Behavioural Brain Research.

Analysis of gene expression in two large schizophrenia cohorts identifies multiple changes associated with nerve terminal function

M. Barnes, P. Maycox, M. Lennon, 2010, Molecular Psychiatry.

Anxiolytic profile of ropinirole in the rat, mouse and common marmoset

J. Hagan, B. Costall, A. Hunter, 2000, Psychopharmacology.

The selective 5-HT6 receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats

J. Hagan, C. Regan, F. Walsh, 2008, Neuropharmacology.

Design and synthesis of trans-N-[4-[2-(6-cyano-1,2,3, 4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): A potent and selective dopamine D(3) receptor antagonist with high oral bioavailability and CNS penetration in the rat.

J. Hagan, D. Middlemiss, K. Thewlis, 2000, Journal of medicinal chemistry.

Effects of granisetron, a 5-HT3 receptor antagonist, on morphine-induced potentiation of brain stimulation reward.

P. Rompré, J. Hagan, R. Injoyan, 1995, European journal of pharmacology.

The 5 -HT3 receptor antagonists, granisetron and ondansetron, do not affect cocaine-induced shifts in intra-cranial self-stimulation thresholds

J. Hagan, J. Hatcher, P. Boyland, 1995, Journal of psychopharmacology.

Neuronal plasticity, stress and depression: involvement of the cytoskeletal microtubular system?

J. Hagan, C. Heidbreder, M. Bianchi, 2005, Current drug targets. CNS and neurological disorders.

Simultaneous blockade of 5-HT1A/B receptors and 5-HT transporters results in acute increases in extracellular 5-HT in both rats and guinea pigs: in vivo characterization of the novel 5-HT1A/B receptor antagonist/5-HT transport inhibitor SB-649915-B

J. Hagan, C. Scott, T. Sharp, 2007, Psychopharmacology.

Morphological, neurochemical, and behavioral studies on serotonergic denervation and graft-induced reinnervation of the rat hippocampus

H. Steinbusch, J. Hagan, H. Dijkstra, 1991, Neuroscience.

Effect of the acute and chronic administration of the selective 5‐HT6 receptor antagonist SB‐271046 on the activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study

K. Hashimoto, J. Hagan, Y. Minabe, 2004, Synapse.

Short-term individual housing induced social deficits in female Mongolian gerbils: Attenuation by chronic but not acute imipramine

J. Hagan, C. Hendrie, A. Pickles, 2012, Neuropharmacology.

Novel pharmacotherapeutic approaches for the treatment of drug addiction and craving.

J. Hagan, C. Heidbreder, 2005, Current opinion in pharmacology.

Selective Antagonism at Dopamine D3 Receptors Enhances Monoaminergic and Cholinergic Neurotransmission in the Rat Anterior Cingulate Cortex

J. Hagan, M. Hows, C. Heidbreder, 2003, Neuropsychopharmacology.

Design and synthesis of 2-naphthoate esters as selective dopamine D4 antagonists.

J. Hagan, D. Middlemiss, G. Riley, 1996, Journal of medicinal chemistry.

Post training lysine-vasopressin injections increase conditioned suppression in rats

J. Hagan, 1983, Physiology & Behavior.

SB-649915-B, a Novel 5-HT1A/B Autoreceptor Antagonist and Serotonin Reuptake Inhibitor, is Anxiolytic and Displays Fast Onset Activity in the Rat High Light Social Interaction Test

Neil Upton, J. Hagan, G. W. Price, 2007, Neuropsychopharmacology.

5-HT6 receptor antagonists improve performance in an attentional set shifting task in rats

V. Brown, J. Hagan, S. Bate, 2005, Psychopharmacology.

SB-699551-A (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4′-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride), a novel 5-ht5A receptor-selective antagonist, enhances 5-HT neuronal function: Evidence for an autoreceptor role for the 5-ht5A receptor in guinea pig brain

Ceri H. Davies, Jim J. Hagan, C. Davies, 2006, Neuropharmacology.

The effect of SB‐269970, a 5‐HT7 receptor antagonist, on 5‐HT release from serotonergic terminals and cell bodies

C. Langmead, J. Hagan, D. Middlemiss, 2001, British journal of pharmacology.

Chronic mild stress-induced reductions in saccharin intake depend upon feeding status

J. Hagan, J. Hatcher, D.J. Bell, 1997, Journal of psychopharmacology.

The role of central dopamine D3 receptors in drug addiction: a review of pharmacological evidence

J. Hagan, P. Thanos, Z. Xi, 2005, Brain Research Reviews.

Design and synthesis of trans-3-(2-(4-((3-(3-(5-methyl-1,2,4-oxadiazolyl))- phenyl)carboxamido)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine (SB-414796): a potent and selective dopamine D3 receptor antagonist.

J. Hagan, G. Macdonald, D. Middlemiss, 2003, Journal of medicinal chemistry.

N-desmethylclozapine (NDMC) is an antagonist at the human native muscarinic M1 receptor

C. Langmead, C. Davies, J. Hagan, 2010, Neuropharmacology.

Lysine vasopressin fails to alter (3H)-noradrenaline uptake or release from hippocampal tissue in vitro.

J. Hagan, D. Balfour, 1983, Life sciences.

SB-649915, a novel, potent 5-HT1A and 5-HT1B autoreceptor antagonist and 5-HT re-uptake inhibitor in native tissue.

Christopher J Langmead, Jeannette Watson, C. Langmead, 2006, European journal of pharmacology.