Lei Guo

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The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements.

Hanlee P. Ji, G. M. Fischer, Stephen C. Harris, 2006, Nature biotechnology.

A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control consortium

David P. Kreil, Todd M. Smith, Thomas M. Blomquist, 2014, Nature Biotechnology.

Cross-platform comparison of SYBR® Green real-time PCR with TaqMan PCR, microarrays and other gene expression measurement technologies evaluated in the MicroArray Quality Control (MAQC) study

Lei Guo, Baitang Ning, Lei Guo, 2008, BMC Genomics.

A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages

C. Mason, Tieliu Shi, Y. Nikolsky, 2014, Nature Communications.

Rat toxicogenomic study reveals analytical consistency across microarray platforms

Stephen C. Harris, P. Hurban, Leming Shi, 2006, Nature Biotechnology.

Analysis of gene expression changes of drug metabolizing enzymes in the livers of F344 rats following oral treatment with kava extract.

Lei Guo, S. Dial, P. Fu, 2009, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Gene Expression Profiling as an Initial Approach for Mechanistic Studies of Toxicity and Tumorigenicity of Herbal Plants and Herbal Dietary Supplements

Lei Guo, N. Mei, Tao Chen, 2010, Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews.

Ginkgo biloba extract induces gene expression changes in xenobiotics metabolism and the Myc-centered network.

Lei Guo, N. Mei, P. Fu, 2010, Omics : a journal of integrative biology.

Methysticin and 7,8-dihydromethysticin are two major kavalactones in kava extract to induce CYP1A1.

Leming Shi, Lei Guo, H. Mei, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

The role of CYP 3A4 and 1A1 in amiodarone-induced hepatocellular toxicity.

Lei Guo, B. Ning, J. Xuan, 2016, Toxicology letters.

Guidelines for the use and interpretation of assays formonitoring autophagy (3rd edition)

Sangeeta Khare, Xin Qi, Ying Wang, 2016 .

Methods for Establishing and Using a Stable Cell Line Expressing Both Gaussia Luciferase and Firefly Luciferase to Screen for Endoplasmic Reticulum Stress.

Lei Guo, Zhen Ren, Si Chen, 2020, Methods in molecular biology.

The Reproducibility of Lists of Differentially Expressed Genes in Microarray Studies

Weida Tong, Qian Xie, Huixiao Hong, 2007 .

Mitochondrial dysfunction induced by sertraline, an antidepressant agent.

Lei Guo, Jia-Long Fang, L. Couch, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Coordinated Regulation of UGT2B15 Expression by Long Noncoding RNA LINC00574 and hsa-miR-129-5p in HepaRG Cells

W. Tong, Lei Guo, B. Ning, 2020, Drug Metabolism and Disposition.

Application of DNA Microarray in Studies of Herbal Dietary Supplements

J. Fuscoe, Lei Guo, N. Mei, 2011 .

Gene Expression Profiling in Evaluating the Safety and Toxicity of Nutraceuticals

Lei Guo, N. Mei, B. Ning, 2016 .

Self-self hybridization as an alternative experiment design to dye swap for two-color microarrays.

Leming Shi, W. Tong, Y. Dragan, 2007, Omics : a journal of integrative biology.

Development and application of TK6-derived cells expressing human cytochrome P450s for genotoxicity testing.

Lei Guo, N. Mei, K. Witt, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

Effects of cellular differentiation in human primary bronchial epithelial cells: Metabolism of 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone.

Lei Guo, H. Rosenfeldt, Qiangen Wu, 2019, Toxicology in vitro : an international journal published in association with BIBRA.

Inhibition of bile salt transport by drugs associated with liver injury in primary hepatocytes from human, monkey, dog, rat, and mouse.

W. Tong, W. Ge, Lei Guo, 2016, Chemico-biological interactions.

The role of hepatic cytochrome P450s in the cytotoxicity of sertraline

Lei Guo, N. Mei, B. Ning, 2020, Archives of Toxicology.

A mechanism of perhexiline's cytotoxicity in hepatic cells involves endoplasmic reticulum stress and p38 signaling pathway.

Lei Guo, Zhen Ren, Si Chen, 2020, Chemico-biological interactions.

Endoplasmic Reticulum Stress and Store-Operated Calcium Entry Contribute to Usnic Acid-Induced Toxicity in Hepatic Cells.

Lei Guo, N. Mei, Q. Shi, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Sertraline induces endoplasmic reticulum stress in hepatic cells.

Lei Guo, J. Xuan, Quanzhen Li, 2014, Toxicology.

A comprehensive rat transcriptome built from large scale RNA-seq-based annotation

David P. Kreil, Paweł P. Łabaj, Tieliu Shi, 2020, Nucleic acids research.

Evaluation of pyrrolizidine alkaloid-induced genotoxicity using metabolically competent TK6 cell lines.

Lei Guo, N. Mei, K. Witt, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Brivanib Exhibits Potential for Pharmacokinetic Drug-Drug Interactions and the Modulation of Multidrug Resistance through the Inhibition of Human ABCG2 Drug Efflux Transporter and CYP450 Biotransformation Enzymes.

Lei Guo, M. Ceckova, F. Staud, 2019, Molecular pharmaceutics.

microRNA Profiling: Strategies and Challenges

Leming Shi, Lei Guo, J. Xuan, 2013 .

Gene expression profiling in male B6C3F1 mouse livers exposed to kava identifies--changes in drug metabolizing genes and potential mechanisms linked to kava toxicity.

Lei Guo, N. Mei, Q. Shi, 2010, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

The role of hepatic cytochrome P450s in the cytotoxicity of dronedarone

Lei Guo, B. Ning, Qiangen Wu, 2018, Archives of Toxicology.

The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells.

Lei Guo, N. Mei, K. Witt, 2021, Toxicology letters.

Assessment of usnic acid toxicity in rat primary hepatocytes using ¹³C isotopomer distribution analysis of lactate, glutamate and glucose.

Lei Guo, L. Boros, Q. Shi, 2011, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Carvedilol inhibits EGF-mediated JB6 P+ colony formation through a mechanism independent of adrenoceptors

Lei Guo, B. Andresen, Ying Huang, 2019, PloS one.

FREMSA: A Method That Provides Direct Evidence of the Interaction between microRNA and mRNA.

Lei Guo, B. Ning, Dianke Yu, 2020, Methods in molecular biology.

Toxicity of Kava Kava

Lei Guo, Hongtao Yu, P. Fu, 2008, Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews.

Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity.

Lei Guo, N. Mei, B. Ning, 2021, Journal of environmental science and health. Part C, Toxicology and carcinogenesis.

Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea

Leming Shi, Lei Guo, Zhiguang Li, 2010, BMC Genomics.

Chemopreventive anti-cancer agent acyclic retinoid suppresses allogeneic immune responses in rats.

Lei Guo, S. Enosawa, S. Uemoto, 2010, International immunopharmacology.

Mechanistic evaluation of Ginkgo biloba leaf extract-induced genotoxicity in L5178Y cells.

Lei Guo, N. Mei, S. Dial, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Roles of CYP3A4, CYP3A5 and CYP2C8 drug-metabolizing enzymes in cellular cytostatic resistance.

Lei Guo, J. Hofman, Si Chen, 2021, Chemico-biological interactions.

Long noncoding RNA LINC00844-mediated molecular network regulates expression of drug metabolizing enzymes and nuclear receptors in human liver cells

W. Tong, Lei Guo, B. Ning, 2020, Archives of Toxicology.

Application of Systems Biology in Neurotoxicological Studies During Development

Lei Guo, T. Patterson, W. Slikker, 2011 .

The role of hepatic cytochrome P450s in the cytotoxicity of dronedarone

Lei Guo, B. Ning, Qiangen Wu, 2018, Archives of Toxicology.

Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine

J. Fuscoe, Lei Guo, Ching-Wei Chang, 2013, Archives of Toxicology.

In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells.

Lei Guo, S. Choudhuri, F. Beland, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Development of benchmark datasets for text mining and sentiment analysis to accelerate regulatory literature review.

W. Tong, Lei Guo, Joshua Xu, 2022, Regulatory toxicology and pharmacology : RTP.

Review of Ginkgo biloba-induced toxicity, from experimental studies to human case reports

Lei Guo, N. Mei, Xiaoqing Guo, 2017, Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews.

MicroRNA hsa‐miR‐370‐3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation

Tieliu Shi, W. Tong, Lei Guo, 2017, Biochemical pharmacology.

Autophagy in drug-induced liver toxicity

Lei Guo, Yuanfeng Wu, Si Chen, 2014, Journal of food and drug analysis.

Review of Usnic Acid and Usnea Barbata Toxicity

Lei Guo, N. Mei, Q. Shi, 2008, Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews.

Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum officinale)

Tao Chen, Lu Zhang, Leming Shi, 2006, BMC Bioinformatics.

Genotoxic effects of acrylamide and glycidamide in mouse lymphoma cells.

Lei Guo, N. Mei, Tao Chen, 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Phototoxicity of kava - formation of reactive oxygen species leading to lipid peroxidation and DNA damage.

Lei Guo, P. Fu, Q. Xia, 2012, The American journal of Chinese medicine.

Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells.

Leming Shi, Lei Guo, B. Ning, 2017, Toxicology.

Genotoxicity evaluation of nutraceuticals

Lei Guo, N. Mei, Xiaoqing Guo, 2021 .

Smokeless tobacco impacts oral microbiota in a Syrian Golden hamster cheek pouch carcinogenesis model.

Lei Guo, C. Cerniglia, M. Vanlandingham, 2018, Anaerobe.

Reactive oxygen species and c-Jun N-terminal kinases contribute to TEMPO-induced apoptosis in L5178Y cells.

Lei Guo, N. Mei, S. Dial, 2015, Chemico-biological interactions.

microRNAs in Drug‐Induced Liver Toxicity

Lei Guo, J. Xuan, Si Chenand, 2013 .

Mitochondrial dysfunction induced by leflunomide and its active metabolite.

Leming Shi, Lei Guo, T. Qing, 2018, Toxicology.

Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis

W. Xiao, W. Tong, Lei Guo, 2019, Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews.

microRNAs as pharmacogenomic biomarkers for drug efficacy and drug safety assessment.

Huixiao Hong, Si Chen, Lei Guo, 2015, Biomarkers in medicine.

Systematic and Simultaneous Gene Profiling of 84 Drug-Metabolizing Genes in Primary Human Hepatocytes

Lei Guo, B. Ning, S. Dial, 2008, Journal of biomolecular screening.

Assessment of Genotoxic Effects of Selected Herbal Dietary Supplements**The information in this chapter is not a formal dissemination of information by the US Food and Drug Administration and does not represent agency position or policy.

Lei Guo, N. Mei, Si Chen, 2016 .

Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine

J. Fuscoe, Lei Guo, T. Han, 2013, Archives of Toxicology.

Transcriptomic profiling for safety and toxicity evaluation of nutraceuticals

Lei Guo, N. Mei, B. Ning, 2021 .

MicroRNA-Dependent Gene Regulation of the Human Cytochrome P450

W. Xiao, W. Tong, Lei Guo, 2019, Pharmacoepigenetics.

Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity.

Lei Guo, B. Ning, J. Xuan, 2016, Chemico-biological interactions.

Using a Lentivirus-Based Inducible RNAi Vector to Silence a Gene.

Lei Guo, N. Mei, B. Ning, 2020, Methods in molecular biology.

Evaluation of external RNA controls for the assessment of microarray performance

Weida Tong, Huixiao Hong, Leming Shi, 2006, Nature Biotechnology.

Leming Shi, Lei Guo, B. Ning, 2011, Drug Metabolism And Disposition.

A testing strategy to predict risk for drug-induced liver injury in humans using high-content screen assays and the ‘rule-of-two’ model

Weida Tong, Leming Shi, Hong Fang, 2014, Archives of Toxicology.

Cross-platform comparability of microarray technology: Intra-platform consistency and appropriate data analysis procedures are essential

Tao Han, James J. Chen, Weida Tong, 2005, BMC Bioinformatics.

Microarray scanner calibration curves: characteristics and implications

Tao Han, James J. Chen, Weida Tong, 2005, BMC Bioinformatics.

Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells

Lei Guo, N. Mei, J. Xuan, 2015, Scientific Reports.

DNA damage‐induced apoptosis and mitogen‐activated protein kinase pathway contribute to the toxicity of dronedarone in hepatic cells

Lei Guo, B. Ning, Dianke Yu, 2018, Environmental and molecular mutagenesis.

The expression of Phase II drug-metabolizing enzymes in human B-lymphoblastoid TK6 cells

Lei Guo, N. Mei, J. Bonzo, 2022, Journal of environmental science and health. Part C, Toxicology and carcinogenesis.

ROS generation and JNK activation contribute to 4-methoxy-TEMPO-induced cytotoxicity, autophagy, and DNA damage in HepG2 cells

Lei Guo, N. Mei, Xiaoqing Guo, 2018, Archives of Toxicology.

Use of Liver-Derived Cell Lines for the Study of Drug-Induced Liver Injury

Lei Guo, B. Ning, Si Chen, 2018 .

Identification of translational microRNA biomarker candidates for ketoconazole-induced liver injury using next-generation sequencing.

W. Tong, Lei Guo, B. Ning, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies

Catalin C. Barbacioru, Leming Shi, Hong Fang, 2008, BMC Bioinformatics.

Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans

W. Xiao, Tieliu Shi, Leming Shi, 2018, Archives of Toxicology.

Mechanism study of goldenseal-associated DNA damage

Lei Guo, N. Mei, Liqing Wan, 2013, Toxicology letters.

A systematic evaluation of microRNAs in regulating human hepatic CYP2E1

W. Tong, Lei Guo, B. Ning, 2017, Biochemical pharmacology.

Endoplasmic Reticulum Stress Induction and ERK1/2 Activation Contribute to Nefazodone-Induced Toxicity in Hepatic Cells.

Lei Guo, Jie Zhang, Albert P. Li, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

The MicroArray Quality Control (MAQC) Project and Cross-Platform Analysis of Microarray Data

Lei Guo, Zhenqiang Su, Zhining Wen, 2011, Handbook of Statistical Bioinformatics.

Gene expression changes induced by the tumorigenic pyrrolizidine alkaloid riddelliine in liver of Big Blue rats

Tao Chen, James C. Fuscoe, Lei Guo, 2007, BMC Bioinformatics.

Mechanisms of tolvaptan-induced toxicity in HepG2 cells.

Lei Guo, F. Beland, Yuanfeng Wu, 2015, Biochemical pharmacology.

Study of the roles of cytochrome P450 (CYPs) in the metabolism and cytotoxicity of perhexiline

Lei Guo, Feng Li, Zhen Ren, 2022, Archives of Toxicology.

Mitochondrial dysfunction and apoptosis underlie the hepatotoxicity of perhexiline.

Lei Guo, B. Ning, Xiaoqing Guo, 2020, Toxicology in vitro : an international journal published in association with BIBRA.

Metabolism, Genotoxicity, annd Carcinogenicity of Comfrey

J. Fuscoe, Lei Guo, N. Mei, 2010, Journal of toxicology and environmental health. Part B, Critical reviews.

Comparison of gene expression profiles altered by comfrey and riddelliine in rat liver

Tao Chen, James C. Fuscoe, Lei Guo, 2007, BMC Bioinformatics.

Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway.

Lei Guo, N. Mei, Liqing Wan, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

Repeat oral dose toxicity studies of melamine in rats and monkeys

Lei Guo, Hong Yu, R. Early, 2013, Archives of Toxicology.

Gene Expression Profiles Distinguish the Carcinogenic Effects of Aristolochic Acid in Target (Kidney) and Non-target (Liver) Tissues in Rats

Tao Chen, Lu Zhang, Leming Shi, 2006, BMC Bioinformatics.

Nitroxide TEMPO: a genotoxic and oxidative stress inducer in cultured cells.

R. Mittelstaedt, Lei Guo, N. Mei, 2013, Toxicology in vitro : an international journal published in association with BIBRA.

Endoplasmic Reticulum Stress in Drug- and Environmental Toxicant-Induced Liver Toxicity

Lei Guo, Si Chen, W. Melchior, 2014, Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews.

Approaches and Practical Considerations for the Analysis of Toxicogenomics Data

Weida Tong, Huixiao Hong, Leming Shi, 2011 .

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Sara W. Bird, Erinna F. Lee, Michael D. Kim, 2016 .

Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice

Lei Guo, Jin Wang, M. Matzuk, 2021, Drug Metabolism and Disposition.

Ensartinib (X-396) Effectively Modulates Pharmacokinetic Resistance Mediated by ABCB1 and ABCG2 Drug Efflux Transporters and CYP3A4 Biotransformation Enzyme

Lei Guo, E. Novotná, F. Staud, 2020, Cancers.

Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor alpha agonists

Leming Shi, W. Tong, Y. Dragan, 2006, BMC Bioinform..

Editorial :Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). DOI: 10.1080/15548627.2015.1100356;WOS:000373595400001; 2-s2.0-85013763791&;PMID: 26799652

Lee, Duchen, Izzo, 2016 .

The expression, induction and pharmacological activity of CYP1A2 are post‐transcriptionally regulated by microRNA hsa‐miR‐132–5p

W. Tong, Lei Guo, N. Mei, 2017, Biochemical pharmacology.

Gene expression changes associated with xenobiotic metabolism pathways in mice exposed to acrylamide

Lei Guo, N. Mei, S. Dial, 2008, Environmental and molecular mutagenesis.

MicroRNAs hsa-miR-495-3p and hsa-miR-486-5p Suppress Basal and Rifampicin-induced Expression of Human Sulfotransferase 2A1 (SULT2A1) by Facilitating mRNA Degradation.

W. Tong, Lei Guo, B. Ning, 2019, Biochemical pharmacology.

Modulation of ALDH5A1 and SLC22A7 by microRNA hsa-miR-29a-3p in human liver cells.

Lei Guo, B. Ning, Dianke Yu, 2015, Biochemical pharmacology.

Inhalation Anesthesia-Induced Neuronal Damage and Gene Expression Changes in Developing Rat Brain.

Leming Shi, Lei Guo, T. Patterson, 2013, Systems pharmacology.

A testing strategy to predict risk for drug-induced liver injury in humans using high-content screen assays and the ‘rule-of-two’ model

Leming Shi, W. Tong, H. Fang, 2014, Archives of Toxicology.

Differences in hepatotoxicity and gene expression profiles by anti-diabetic PPAR γ agonists on rat primary hepatocytes and human HepG2 cells

G. Schroth, Leming Shi, Y. Sun, 2006, Molecular Diversity.

Activation of the Nrf2 signaling pathway in usnic acid-induced toxicity in HepG2 cells

Leming Shi, Lei Guo, N. Mei, 2017, Archives of Toxicology.

The role of autophagy in usnic acid-induced toxicity in hepatic cells.

Lei Guo, N. Mei, Yuanfeng Wu, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

P53-M Real-Time PCR Array for Multi-Gene Expression Profiling and Microarray Data Validation: RT2 Profiler PCR Array.

Y. Dragan, Lei Guo, B. Ning, 2007 .

Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor α agonists

Weida Tong, Leming Shi, Hong Fang, 2006, BMC Bioinformatics.

Changes in gene expression after phencyclidine administration in developing rats: a potential animal model for schizophrenia

Leming Shi, Lei Guo, T. Patterson, 2011, International Journal of Developmental Neuroscience.

Leming Shi, Lei Guo, B. Ning, 2011, Drug Metabolism and Disposition.