A. Simon

发表

Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects

R. Petersen, J. Trojanowski, K. Blennow, 2009, Annals of neurology.

Update on the biomarker core of the Alzheimer's Disease Neuroimaging Initiative subjects

C. Jack, M. Weiner, A. Toga, 2010, Alzheimer's & Dementia.

Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).

Alison R. Gregro, Amy S. Espeseth, Min Xu, 2004, Journal of medicinal chemistry.

Effects of Exercise on EEG Activity and Standard Tools Used to Assess Concussion

Mayuresh V Kothare, David M Devilbiss, M. Kothare, 2019, Journal of healthcare engineering.

A novel pathway for amyloid precursor protein processing

K. Blennow, A. Simon, H. Zetterberg, 2011, Neurobiology of Aging.

Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1).

Min Xu, Qian Huang, D. Hazuda, 2006, Journal of medicinal chemistry.

Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity

Henryk Mach, Norman L. Letvin, Michelle A. Lifton, 2002, Nature.

In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.

A. Simon, S. Stachel, C. Coburn, 2008, The Journal of pharmacology and experimental therapeutics.

Discovery of Isonicotinamide Derived β-Secretase Inhibitors: In Vivo Reduction of β-Amyloid

Alison R. Gregro, Amy S. Espeseth, Min Xu, 2007 .

Discovery of isonicotinamide derived beta-secretase inhibitors: in vivo reduction of beta-amyloid.

Alison R. Gregro, Amy S. Espeseth, Min Xu, 2007, Journal of medicinal chemistry.

Compounds that bind APP and inhibit Abeta processing in vitro suggest a novel approach to Alzheimer disease therapeutics.

Amy S. Espeseth, Min Xu, Qian Huang, 2005, The Journal of biological chemistry.

STOCHASTIC DYNAMIC MODELING OF THE HUMAN BRAIN EEG SIGNAL

Subramanian Ramakrishnan, Parham Ghorbanian, Hashem Ashrafiuon, 2013 .

Antigen levels and antibody titers after DNA vaccination.

A. Simon, C. R. Middaugh, D. Holder, 2001, Journal of pharmaceutical sciences.

Strategies toward improving the brain penetration of macrocyclic tertiary carbinamine BACE-1 inhibitors.

A. Simon, G. McGaughey, Hemaka A. Rajapakse, 2007, Bioorganic & medicinal chemistry letters.

Sustained Peptide-Specific Gamma Interferon T-Cell Response in Rhesus Macaques Immunized with Human Immunodeficiency Virus gag DNA Vaccines

R. K. Evans, A. Simon, J. Shiver, 2002, Journal of Virology.

Cerebrospinal fluid biomarkers distinguish postmortem-confirmed Alzheimer's disease from other dementias and healthy controls in the OPTIMA cohort.

A. Simon, W. Potter, A. Smith, 2015, Journal of Alzheimer's disease : JAD.

Enhancing B- and T-Cell Immune Response to a Hepatitis C Virus E2 DNA Vaccine by Intramuscular Electrical Gene Transfer

A. Folgori, R. Cortese, A. Nicosia, 2000, Journal of Virology.

Plasma biomarkers associated with the apolipoprotein E genotype and Alzheimer disease.

Walter J Koroshetz, Max Kuhn, Madhav Thambisetty, 2012, Archives of neurology.

Safety and Immunogenicity of the Candidate Tuberculosis Vaccine MVA85A in West Africa

A. Simon, R. Adegbola, H. McShane, 2008, PloS one.

Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination.

A. Simon, A. Craiu, D. Montefiori, 2000, Science.

Machine learning for comprehensive forecasting of Alzheimer’s Disease progression

Jonathan R. Walsh, Aaron M. Smith, Charles K. Fisher, 2018, Scientific Reports.

Design and Synthesis of 2,3,5‐Substituted Imidazolidin‐4‐one Inhibitors of BACE‐1

Amy S. Espeseth, Qian Huang, A. Espeseth, 2007, ChemMedChem.

Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors.

D. Hazuda, A. Simon, G. McGaughey, 2007, Bioorganic & medicinal chemistry letters.

Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potency.

A. Simon, G. McGaughey, J. Barrow, 2015, Bioorganic & medicinal chemistry letters.

Macrocyclic Inhibitors of β-Secretase: Functional Activity in an Animal Model.

M. Katharine Holloway, Adam J. Simon, Lixia Jin, 2006 .

Persistent Replication of Hepatitis C Virus Replicons Expressing the β-Lactamase Reporter in Subpopulations of Highly Permissive Huh7 Cells

A. Simon, G. Paonessa, J. Grobler, 2003, Journal of Virology.

Screening for New Biomarkers for Subcortical Vascular Dementia and Alzheimer's Disease

K. Blennow, A. Simon, W. Potter, 2011, Dementia and Geriatric Cognitive Disorders Extra.

Construction of an rtTA2s-m2/ttskid-Based transcription regulatory switch that displays no basal activity, good inducibility, and high responsiveness to doxycycline in mice and Non-Human primates

R. Cortese, A. Simon, H. Bujard, 2003 .

First Demonstration of Cerebrospinal Fluid and Plasma Aβ Lowering with Oral Administration of a β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates

Alison R. Gregro, Amy S. Espeseth, Min Xu, 2009, Journal of Pharmacology and Experimental Therapeutics.

O3-02-06: Elevated cerebrospinal fluid BACE1 activity in incipient Alzheimer's disease

K. Blennow, E. Londos, A. Simon, 2008, Alzheimer's & Dementia.

In Vivo β-Secretase 1 Inhibition Leads to Brain Aβ Lowering and Increased α-Secretase Processing of Amyloid Precursor Protein without Effect on Neuregulin-1

A. Simon, S. Stachel, C. Coburn, 2008, Journal of Pharmacology and Experimental Therapeutics.

First Demonstration of Cerebrospinal Fluid and Plasma A (cid:1) Lowering with Oral Administration of a (cid:1) -Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates □ S

Alison R. Gregro, Amy S. Espeseth, Min Xu, 2008 .

Construction of an rtTA2(s)-m2/tts(kid)-based transcription regulatory switch that displays no basal activity, good inducibility, and high responsiveness to doxycycline in mice and non-human primates.

R. Cortese, A. Simon, H. Bujard, 2003, Molecular therapy : the journal of the American Society of Gene Therapy.

Qualification of the analytical and clinical performance of CSF biomarker analyses in ADNI

Robert A. Dean, Leslie M. Shaw, John Q. Trojanowski, 2011, Acta Neuropathologica.

Regulation of Gene Expression by Lithium and Depletion of Inositol in Slices of Adult Rat Cortex

Robert L. Phillips, M. Parrish, A. Simon, 2005, Neuron.

Vaccine-Induced Immune Responses in Rodents and Nonhuman Primates by Use of a Humanized Human Immunodeficiency Virus Type 1 pol Gene

D. Richman, A. Simon, D. Havlir, 2002, Journal of Virology.

Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex

A. Simon, S. Sankaranarayanan, M. Savage, 2011, Journal of neuroscience research.

Evaluation of Plasma Proteomic Data for Alzheimer Disease State Classification and for the Prediction of Progression From Mild Cognitive Impairment to Alzheimer Disease

Viswanath Devanarayan, Daniel A. Llano, Adam J. Simon, 2013, Alzheimer disease and associated disorders.

LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease

Shane D. Marine, Amy S. Espeseth, Min Xu, 2006, Proceedings of the National Academy of Sciences.

A genome wide analysis of ubiquitin ligases in APP processing identifies a novel regulator of BACE1 mRNA levels

Min Xu, Xiao-Ping Shi, Yuanjiang Yu, 2006, Molecular and Cellular Neuroscience.

Exploration of EEG features of Alzheimer’s disease using continuous wavelet transform

A. Simon, A. Bernstein, H. Ashrafiuon, 2015, Medical & Biological Engineering & Computing.

Identification of Resting and Active State EEG Features of Alzheimer’s Disease using Discrete Wavelet Transform

Parham Ghorbanian, Hashem Ashrafiuon, David M. Devilbiss, 2013, Annals of Biomedical Engineering.

SAR of tertiary carbinamine derived BACE1 inhibitors: role of aspartate ligand amine pKa in enzyme inhibition.

Adam J. Simon, Georgia B. McGaughey, Philippe G. Nantermet, 2010, Bioorganic & medicinal chemistry letters.

Characterization of plasma β‐secretase (BACE1) activity and soluble amyloid precursor proteins as potential biomarkers for Alzheimer's disease

A. Simon, Katherine Tugusheva, S. Sankaranarayanan, 2012, Journal of neuroscience research.

High-Throughput Screening by RNA Interference: Control of Two Distinct Types of Variance

Shane D. Marine, Amy S. Espeseth, M. Ferrer, 2007, Cell cycle.

Acute γ-Secretase Inhibition of Nonhuman Primate CNS Shifts Amyloid Precursor Protein (APP) Metabolism from Amyloid-β Production to Alternative APP Fragments without Amyloid-β Rebound

A. Simon, R. Bateman, K. Yarasheski, 2010, The Journal of Neuroscience.

Discrete wavelet transform EEG features of Alzheimer'S disease in activated states

Parham Ghorbanian, Hashem Ashrafiuon, T. Hess, 2012, 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

Continuous Wavelet Transform EEG Features of Alzheimer’s Disease

Parham Ghorbanian, Hashem Ashrafiuon, David M. Devilbiss, 2012 .

Power based analysis of single-electrode human EEG recordings using continuous wavelet transform

H. Ashrafiuon, P. Ghorbanian, D. M. Devilbiss, 2012, 2012 38th Annual Northeast Bioengineering Conference (NEBEC).

Modeling Effect of a γ-Secretase Inhibitor on Amyloid-β Dynamics Reveals Significant Role of an Amyloid Clearance Mechanism

Raibatak Das, Daniel Coombs, Leah Edelstein-Keshet, 2011, Bulletin of mathematical biology.

Novel mutations introduced at the β-site of amyloid β protein precursor enhance the production of amyloid β peptide by BACE1 in vitro and in cells

Amy S. Espeseth, Min Xu, Qian Huang, 2005 .

Novel mutations introduced at the β-site of amyloid β protein precursor enhance the productio no famyloi d βpeptid eb yBACE 1in vitr oan di ncells

Amy S. Espeseth, Min Xu, Qian Huang, 2005 .

Biochemical and cell-based assays for characterization of BACE-1 inhibitors.

Xiao-Ping Shi, Amy S Espeseth, Min Xu, 2005, Analytical biochemistry.

Cisterna magna cannulated repeated CSF sampling rat model – effects of a gamma-secretase inhibitor on Aβ levels

A. Simon, S. Sankaranarayanan, Eric A. Price, 2012, Journal of Neuroscience Methods.

Identification of Resting and Active State EEG Features of Alzheimer’s Disease using Discrete Wavelet Transform

A. Simon, A. Bernstein, H. Ashrafiuon, 2013, Annals of Biomedical Engineering.

A cell-based β-lactamase reporter gene assay for the identification of inhibitors of hepatitis C virus replication

James Inglese, Marc Ferrer, Berta Strulovici, 2004 .

Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid‐β oligomers

T. Abel, A. Levey, W. Bilker, 2010, Annals of neurology.

Discovery of aminoheterocycles as a novel beta-secretase inhibitor class: pH dependence on binding activity part 1.

Amy S. Espeseth, A. Espeseth, A. Simon, 2009, Bioorganic & medicinal chemistry letters.

Reference measurement procedures for Alzheimer's disease cerebrospinal fluid biomarkers: definitions and approaches with focus on amyloid β42.

Kevin Mills, Henrik Zetterberg, Niklas Mattsson, 2012, Biomarkers in medicine.

Macrocyclic inhibitors of beta-secretase: functional activity in an animal model.

M Katharine Holloway, Lixia Jin, Michelle Crouthamel, 2006, Journal of medicinal chemistry.

Altering Expression Levels of Human Immunodeficiency Virus Type 1 gp120-gp41 Affects Efficiency but Not Kinetics of Cell-Cell Fusion

D. Hazuda, A. Simon, J. Lineberger, 2002, Journal of Virology.

Decrease in age-adjusted cerebrospinal fluid beta-secretase activity in Alzheimer's subjects.

A. Simon, V. Devanarayan, Katherine Tugusheva, 2008, Clinical biochemistry.

Novel mutations introduced at the beta-site of amyloid beta protein precursor enhance the production of amyloid beta peptide by BACE1 in vitro and in cells.

Min Xu, Qian Huang, D. Hazuda, 2005, Journal of Alzheimer's disease : JAD.

Genetic vaccination by gene electro-transfer in non-human primates

A. Folgori, R. Cortese, A. Nicosia, 2006 .

Rapid P1 SAR of brain penetrant tertiary carbinamine derived BACE inhibitors.

D. Hazuda, A. Simon, Hemaka A. Rajapakse, 2010, Bioorganic & medicinal chemistry letters.

Application of an end-to-end biomarker discovery platform to identify target engagement markers in cerebrospinal fluid by high resolution differential mass spectrometry.

Matthew C Wiener, Fanyu Meng, R. Hendrickson, 2010, Journal of proteome research.

A cell-based beta-lactamase reporter gene assay for the identification of inhibitors of hepatitis C virus replication.

James Inglese, Marc Ferrer, Berta Strulovici, 2004, Analytical biochemistry.

Changes in plasma based biomarkers in Alzheimer's disease, mild cognitively impaired and aged matched normal controls from the ADNI cohort

William T. Hu, D. Shera, J. Trojanowski, 2011, Alzheimer's & Dementia.

Pharmacological applications of a novel neoepitope antibody to a modified amyloid precursor protein-derived beta-secretase product

A. Simon, S. Sankaranarayanan, D. Montgomery, 2011, Protein & Cell.

Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformation.

Alison R. Gregro, Georgia B McGaughey, M Katharine Holloway, 2007, Bioorganic & medicinal chemistry letters.

BACE-1 inhibition by a series of ψ[CH2NH] reduced amide isosteres

M. Katharine Holloway, Adam J. Simon, Lixia Jin, 2006 .

Evolution of Tertiary Carbinamine BACE‐1 Inhibitors: Aβ Reduction in Rhesus CSF upon Oral Dosing

Alison R. Gregro, A. Simon, G. McGaughey, 2009, ChemMedChem.

Activity profile-based siRNA screen to explore the functional genomics of Alzheimer's disease

Shane D. Marine, Amy S. Espeseth, Min Xu, 2007 .

Update on the biomarker core of the Alzheimer's Disease Neuroimaging Initiative subjects

C. Jack, M. Weiner, A. Toga, 2010, Alzheimer's & Dementia.

Reference measurement procedures for Alzheimer's disease cerebrospinal fluid biomarkers: definitions and approaches with focus on amyloid β42.

K. Blennow, M. Carrillo, H. Soares, 2012, Biomarkers in medicine.

Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex

A. Simon, S. Sankaranarayanan, M. Savage, 2011, Journal of neuroscience research.