I. Kola

发表

M. Tymms, I. Kola, 2001 .

A call to reform the taxonomy of human disease

I. Kola, J. Bell, 2011, Nature Reviews Drug Discovery.

Can the pharmaceutical industry reduce attrition rates?

I. Kola, John Landis, 2004, Nature Reviews Drug Discovery.

Response of a primary human fibroblast cell line to H2O2: senescence-like growth arrest or apoptosis?

I. Kola, C. Bladier, E. Wolvetang, 1997, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Ets1 is required for p53 transcriptional activity in UV‐induced apoptosis in embryonic stem cells

Paul J Hertzog, Dakang Xu, I. Kola, 2002, The EMBO journal.

Regulation of the human stress response gene GADD153 expression: role of ETS1 and FLI-1 gene products

I. Kola, A. Seth, S. Giunta, 1999, Cell Death and Differentiation.

Type I interferons mediate the lipopolysaccharide induction of macrophage cyclin D2.

I. Kola, P. Hertzog, P. Vadiveloo, 2000, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics.

I. Kola, R. Motter, K. Johnson-wood, 2001, Human molecular genetics.

The Ets1 transcription factor is widely expressed during murine embryo development and is associated with mesodermal cells involved in morphogenetic processes such as organ formation.

M. Tymms, I. Kola, A. Green, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Down syndrome and mouse models.

I. Kola, P. Hertzog, 1998, Current opinion in genetics & development.

Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation

I. Kola, J. Visvader, Ross S. Thomas, 2005, The EMBO journal.

Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model.

I. Kola, Jinhe Li, C. S. Himes, 2003, The Journal of biological chemistry.

Positive and Negative Regulation of the γ-Secretase Activity by Nicastrin in a Murine Model*

I. Kola, Jinhe Li, C. S. Himes, 2003, Journal of Biological Chemistry.

The LoxP/CRE system and genome modification.

I. Kola, T. Wilson, 2001, Methods in molecular biology.

19 – Antioxidant Genes and Reactive Oxygen Species in Down's Syndrome

I. Kola, J. D. Haan, C. Bladier, 2000 .

Simple minded mice from ‘in vivo’ libraries

I. Kola, I. Kola, 1997, Nature Genetics.

Ets-2 is induced by oxidative stress and sensitizes cells to H(2)O(2)-induced apoptosis: implications for Down's syndrome.

I. Kola, E. Wolvetang, P. Hertzog, 2001, Biochemical and biophysical research communications.

Methylation-dependent Silencing of the Testis-specific Pdha-2 Basal Promoter Occurs through Selective Targeting of an Activating Transcription Factor/cAMP-responsive Element-binding Site*

I. Kola, R. Medcalf, J. Young, 2000, The Journal of Biological Chemistry.

The ETS Transcription Factor GABPα Is Essential for Early Embryogenesis

I. Kola, P. Hertzog, M. Owen, 2004, Molecular and Cellular Biology.

Elf 5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation

I. Kola, J. Visvader, Ross S. Thomas, 2005 .

Identification and expression analysis of alternative transcripts of the mouse GA-binding protein (Gabp) subunits α and β1

I. Kola, P. Hertzog, D. A. O'leary, 2005 .

Tissue-specific overexpression of the HSA21 gene GABPα: implications for DS

I. Kola, Dakang Xu, P. Hertzog, 2004 .

Gene targeting of Desrt, a novel ARID class DNA-binding protein, causes growth retardation and abnormal development of reproductive organs.

I. Kola, L. Jermiin, J. Drago, 2001, Genome research.

Tripronuclear human oocytes: altered cleavage patterns and subsequent karyotypic analysis of embryos.

I. Kola, A. Trounson, P. Rogers, 1987, Biology of reproduction.

The ETS Transcription Factor GABPα Is Essential for Early Embryogenesis

I. Kola, P. Hertzog, M. Owen, 2004, Molecular and Cellular Biology.

Localization of the murine leukemia inhibitory factor gene near the centromere on chromosome 11.

I. Kola, N. Gough, A. Davey, 1990, Growth factors.

The Hsp 70 genes of mice and men

I. Kola, Robin L. Anderson, M. Tavaria, 1997 .

Site-Specific Antiatherogenic Effect of the Antioxidant Ebselen in the Diabetic Apolipoprotein E–Deficient Mouse

I. Kola, M. Febbraio, M. Cooper, 2009, Arteriosclerosis, thrombosis, and vascular biology.

Lack of the Antioxidant Enzyme Glutathione Peroxidase-1 Accelerates Atherosclerosis in Diabetic Apolipoprotein E–Deficient Mice

I. Kola, M. Cooper, J. D. de Haan, 2007, Circulation.

Cu/Zn superoxide dismutase mRNA and enzyme activity, and susceptibility to lipid peroxidation, increases with aging in murine brains.

I. Kola, J. D. de Haan, J. D. Newman, 1992, Brain research. Molecular brain research.

Lack of the antioxidant glutathione peroxidase-1 does not increase atherosclerosis in C57BL/J6 mice fed a high-fat diet Published, JLR Papers in Press, February 28, 2006.

I. Kola, J. D. de Haan, R. Stocker, 2006, Journal of Lipid Research.

Retinal light damage: structural and functional effects of the antioxidant glutathione peroxidase-1.

I. Kola, J. D. de Haan, L. Scurr, 2006, Investigative ophthalmology & visual science.

Changes in the levels of enzymes which modulate the antioxidant balance occur during aging and correlate with cellular damage

I. Kola, R. Iannello, J. Haan, 1995, Mechanisms of Ageing and Development.

Chapter 9 – Down Syndrome, Antioxidant Balance and the “Gene Dosage Effect” Hypothesis

I. Kola, P. Crack, M. Pritchard, 2007 .

An altered antioxidant balance occurs in Down syndrome fetal organs: implications for the "gene dosage effect" hypothesis.

I. Kola, J. D. de Haan, M. Pritchard, 2003, Journal of neural transmission. Supplementum.

Kidney expression of glutathione peroxidase-1 is not protective against streptozotocin-induced diabetic nephropathy.

R. Atkins, I. Kola, J. D. de Haan, 2005, American journal of physiology. Renal physiology.

A gene on human chromosome 21 located in the region 21q22.2 to 21q22.3 encodes a factor necessary for signal transduction and antiviral response to type I interferons.

M. Tymms, I. Kola, S. Hwang, 1994, The Journal of biological chemistry.

Identification and characterization of alternatively spliced murine Rgs11 isoforms: genomic structure and gene analysis

S. Rastan, I. Kola, P. Hertzog, 2001, Cytogenetic and Genome Research.

Role of interferons in the regulation of cell proliferation, differentiation, and development

I. Kola, Paul J. Hertzog, Seung Y. Hwang, 1994, Molecular reproduction and development.

Endogenous IFN-alpha beta suppresses colony-stimulating factor (CSF)-1-stimulated macrophage DNA synthesis and mediates inhibitory effects of lipopolysaccharide and TNF-alpha.

I. Kola, P. Hertzog, J. Hamilton, 1996, Journal of immunology.

Cu/Zn-superoxide dismutase and glutathione peroxidase during aging.

I. Kola, J. D. de Haan, R. Iannello, 1995, Biochemistry and molecular biology international.

Targeting of the ETS Factor Gabp (cid:2) Disrupts Neuromuscular Junction Synaptic Function (cid:1) §

I. Kola, P. Hertzog, N. Lavidis, 2007 .

The Effects of Cyclophosphamide on Alkaline Phosphatase Activity and on in vitro Post‐Implantation Murine Blastocyst Development †

I. Kola, P. Folb, 1985 .

Chlorpromazine inhibits the mitotic index, cell number, and formation of mouse blastocysts, and delays implantation of CBA mouse embryos.

I. Kola, P. Folb, 1986, Journal of reproduction and fertility.

Neonatal calyceal dilation and renal fibrosis resulting from loss of Adamts-1 in mouse kidney is due to a developmental dysgenesis.

I. Kola, P. Hertzog, M. Little, 2005, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Complex traits, genes, polymorphisms and the drug discovery/development process.

I. Kola, 1999, Current opinion in biotechnology.

Regulation of Pdha-2 expression is mediated by proximal promoter sequences and CpG methylation

M. Tymms, I. Kola, M. Hedger, 1997, Molecular and cellular biology.

The Ets1 proto-oncogene is upregulated by retinoic acid: characterization of a functional retinoic acid response element in the Ets1 promoter

I. Kola, A. Seth, A. Raouf, 2000, Oncogene.

A Type I Interferon Signaling Factor, ISF21, Encoded on Chromosome 21 Is Distinct from Receptor Components and Their Down-regulation and Is Necessary for Transcriptional Activation of Interferon-regulated Genes*

M. Tymms, I. Kola, S. Constantinescu, 1997, The Journal of Biological Chemistry.

Cathepsin K Knockout Mice Develop Osteopetrosis Due to a Deficit in Matrix Degradation but Not Demineralization

I. Kola, C. Debouck, P. Hertzog, 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

A novel member of the STOMATIN/EPB72/mec-2 family, stomatin-like 2 (STOML2), is ubiquitously expressed and localizes to HSA chromosome 9p13.1

I. Kola, P. Hertzog, H. Treutlein, 2001, Cytogenetic and Genome Research.

Binding of interferon-α and -β to a component of the human type I interferon receptor expressed in simian cells

I. Kola, S. Hwang, P. Hertzog, 1996 .

Role of type I interferons during macrophage activation by lipopolysaccharide.

I. Kola, P. Hertzog, P. Vadiveloo, 2000, Cytokine.

Cloning and Characterization of Soluble and Transmembrane Isoforms of a Novel Component of the Murine Type I Interferon Receptor, IFNAR 2*

I. Kola, S. Hwang, N. Reich, 1997, The Journal of Biological Chemistry.

Transcription factors Ets1, Ets2, and Elf1 exhibit differential localization in human endometrium across the menstrual cycle and alternate isoforms in cultured endometrial cells.

I. Kola, L. Salamonsen, L. M. Kilpatrick, 1999, Biology of reproduction.

Human ERG is a proto-oncogene with mitogenic and transforming activity.

A. Hart, M. Tymms, I. Kola, 1995, Oncogene.

Maternal administration of cyclophosphamide induces chromosomal aberrations and inhibits cell number, histone synthesis, and DNA synthesis in preimplantation mouse embryos.

I. Kola, M. Parker, P. Folb, 1986, Teratogenesis, carcinogenesis, and mutagenesis.

Down's syndrome-like skeletal abnormalities in Ets2 transgenic mice

M. Tymms, I. Kola, T. Wilson, 1996, Nature.

Expression of Copper/Zinc Superoxide Dismutase and Glutathione Peroxidase in Organs of Developing Mouse Embryos, Fetuses, and Neonates

M. Tymms, I. Kola, J. Haan, 1994, Pediatric Research.

Oocyte and Embryo Donation in Women with Absent Ovarian Function

I. Kola, A. Trounson, J. Findlay, 1987 .

Centrioles in the beginning of human development.

I. Kola, A. Trounson, S. Ratnam, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Vitrification of mouse oocytes results in aneuploid zygotes and malformed fetuses.

I. Kola, A. Trounson, J. Shaw, 1988, Teratology.

Chromosomal analysis of human oocytes fertilized by microinjection of spermatozoa into the perivitelline space.

I. Kola, R. Jansen, A. Trounson, 1990, Human reproduction.

An association between chromosomal abnormalities in rapidly frozen 2-cell mouse embryos and the ice-forming properties of the cryoprotective solution.

I. Kola, A. Trounson, D. Macfarlane, 1991, Journal of reproduction and fertility.

Mice Lacking Glutathione Peroxidase-1 Activity Show Increased Tunel Staining and an Accelerated Inflammatory Response in Brain Following a Cold-Induced Injury

I. Kola, P. Hertzog, P. Crack, 2002, Experimental Neurology.

Mice with a Homozygous Null Mutation for the Most Abundant Glutathione Peroxidase, Gpx1, Show Increased Susceptibility to the Oxidative Stress-inducing Agents Paraquat and Hydrogen Peroxide*

P Griffiths, I. Kola, M. Kelner, 1998, The Journal of Biological Chemistry.

Animal models in the study of the biological function of genes on human chromosome 21 and their role in the pathophysiology of Down syndrome.

I. Kola, P. Hertzog, 1997, Human molecular genetics.

In vivo cleavage rates and viability obtained for early cleavage mouse embryos in co-culture with oviduct cells.

I. Kola, A. Trounson, D. Sakkas, 1989, Reproduction, fertility, and development.

Elevation in the ratio of Cu/Zn-superoxide dismutase to glutathione peroxidase activity induces features of cellular senescence and this effect is mediated by hydrogen peroxide.

I. Kola, M. Kelner, J. D. de Haan, 1996, Human molecular genetics.

The soluble murine type I interferon receptor Ifnar-2 is present in serum, is independently regulated, and has both agonistic and antagonistic properties.

I. Kola, P. Hertzog, M. Hardy, 2001, Blood.

A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responses.

M. Tymms, I. Kola, S. Hwang, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Inactivation of the transcription factor Elf3 in mice results in dysmorphogenesis and altered differentiation of intestinal epithelium.

I. Kola, T. Wilson, P. Hertzog, 2002, Gastroenterology.

A novel epithelial-expressed ETS gene, ELF3: human and murine cDNA sequences, murine genomic organization, human mapping to 1q32.2 and expression in tissues and cancer

Martin Rosenberg, M. Tymms, I. Kola, 1997, Oncogene.

Temporal and tissue-specific interactions involving novel transcription factors and the proximal promoter of the mouse Pdha-2 gene.

I. Kola, H. Dahl, R. Iannello, 1993, The Journal of biological chemistry.

The ETS Transcription Factor GABP (cid:2) Is Essential for Early Embryogenesis

I. Kola, P. Hertzog, A. Thornell, 2004 .

Detailed mapping of the ERG-ETS2 interval of human chromosome 21 and comparison with the region of conserved synteny on mouse chromosome 16.

I. Kola, N. Shimizu, J. Kudoh, 2004, Gene.

The Mouse and the Genomic Era

I. Kola, T. Wilson, P. Hertzog, 2000 .

Review: Pdha-2, past and present.

I. Kola, J. Young, J. Gould, 1998, The Journal of experimental zoology.

A model for understanding gene regulation during spermatogenesis: the mouse testis Pdha-2 promoter.

M. Tymms, I. Kola, S. Sumarsono, 1995, Reproduction, fertility, and development.

Pdha‐2: A model for studying transcriptional regulation in early spermatocytes

I. Kola, Rocco C. Iannello, Julia C. Young, 1994, Molecular reproduction and development.

Mouse testis Pdha-2 promoter upstream sequences confer tissue-and temporal-specific activity in transgenic mice.

M. Tymms, I. Kola, S. Sumarsono, 1994, Reproduction, fertility, and development.

Phenotypic Characterization of an α4 Neuronal Nicotinic Acetylcholine Receptor Subunit Knock-Out Mouse

I. Scheffer, J. Waddington, M. Horne, 2000, The Journal of Neuroscience.

Reactive oxygen species and their contribution to pathology in Down syndrome.

I. Kola, M. Kelner, E. Wolvetang, 1997, Advances in pharmacology.

Animal Cytogenetics and Comparative Mapping

S. Rastan, I. Kola, P. Hertzog, 2002 .

Construction of a mouse blastocyst cDNA library by PCR amplification from total RNA

M. Tymms, I. Kola, C. Corrick, 1996, Molecular reproduction and development.

11 – Dispermic Human Fertilization: Violation of Expected Cell Behavior

I. Kola, A. Trounson, 1989 .

Commentary: embryo and fetal abnormalities in IVF.

I. Kola, 1988, Birth.

Fibroblasts derived from Gpx1 knockout mice display senescent-like features and are susceptible to H2O2-mediated cell death.

I. Kola, P. Hutchinson, J. D. de Haan, 2004, Free radical biology & medicine.

An imbalance in antioxidant defense affects cellular function: the pathophysiological consequences of a reduction in antioxidant defense in the glutathione peroxidase-1 (Gpx1) knockout mouse

I. Kola, J. D. de Haan, P. Hertzog, 2003, Redox report : communications in free radical research.

Targeted Expression of a Toxin Gene to D1 Dopamine Receptor Neurons by Cre-Mediated Site-Specific Recombination

I. Kola, A. Lawrence, J. Drago, 1998, The Journal of Neuroscience.

An assessment of the effects of cyclophosphamide and sodium valproate on the viability of preimplantation mouse embryos using the fluorescein diacetate test.

I. Kola, P. Folb, 1986, Teratogenesis, carcinogenesis, and mutagenesis (Print).

Increased infarct size and exacerbated apoptosis in the glutathione peroxidase‐1 (Gpx‐1) knockout mouse brain in response to ischemia/reperfusion injury

I. Kola, J. D. de Haan, P. Hertzog, 2001, Journal of neurochemistry.

The "gene dosage effect" hypothesis versus the "amplified developmental instability" hypothesis in Down syndrome.

I. Kola, M. Pritchard, 1999, Journal of neural transmission. Supplementum.

Embryonic stem cells in the study of hematopoiesis.

I. Kola, A. Elefanty, F. Lazner, 2001, Methods in molecular biology.

Characterisation of the tumour necrosis factor (TNF)-(alpha) response elements in the human ICAM-2 promoter.

I. Kola, A. Randi, C. Campbell, 1999, Journal of cell science.

Molecular genetics of Down syndrome.

I. Kola, 1989, Reproduction, fertility, and development.

The Elf group of Ets-related transcription factors. ELF3 and ELF5.

M. Tymms, I. Kola, J. Zhou, 2000, Advances in experimental medicine and biology.

A novel transcription factor, ELF5, belongs to the ELF subfamily of ETS genes and maps to human chromosome 11p13–15, a region subject to LOH and rearrangement in human carcinoma cell lines

Lars S Jermiin, M. Tymms, I. Kola, 1998, Oncogene.

The chromosome 21 transcription factor ETS2 transactivates the beta-APP promoter: implications for Down syndrome.

M. Tymms, I. Kola, P. Hertzog, 2003, Biochimica et biophysica acta.

ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway.

I. Kola, E. Wolvetang, T. Wilson, 2003, Human molecular genetics.

ETS 2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p 53 pathway

I. Kola, E. Wolvetang, T. Wilson, 2003 .

Oxidative Stress in Down Syndrome

I. Kola, R. Iannello, 2001 .

Oxidative stress and neural dysfunction in Down syndrome.

I. Kola, J. D. de Haan, P. Crack, 1999, Journal of neural transmission. Supplementum.

Regulation of gene expression by transcription factors Ets‐1 and Ets‐2

I. Kola, Martin J. Tymms, 1994, Molecular reproduction and development.

Osteopetrosis and osteoporosis: two sides of the same coin.

I. Kola, M. Gowen, D. Pavasovic, 1999, Human molecular genetics.

An animal model for pycnodysostosis: the role of cathepsin K in bone remodelling.

I. Kola, M. Gowen, F. Lazner, 1999, Molecular medicine today.

A mouse model of spinal and bulbar muscular atrophy.

M. Horne, J. Morrison, I. Kola, 2002, Human molecular genetics.

FLI1 and EWS-FLI1 function as ternary complex factors and ELK1 and SAP1a function as ternary and quaternary complex factors on the Egr1 promoter serum response elements

I. Kola, A. Seth, D. Watson, 1997, Oncogene.

Targeting of the ETS Factor Gabpα Disrupts Neuromuscular Junction Synaptic Function

I. Kola, P. Hertzog, N. Lavidis, 2007, Molecular and Cellular Biology.

Animal models of Down syndrome.

I. Kola, M. Pritchard, 1999, Molecular medicine today.

Co-administration of ascorbic acid with cyclophosphamide (CPA) to pregnant mice inhibits the clastogenic activity of CPA in preimplantation murine blastocysts.

I. Kola, H. Spielmann, R. Vogel, 1989, Mutagenesis.

The incidence of chromosomal aneuploidy in stimulated and unstimulated (natural) uninseminated human oocytes.

I. Kola, A. Trounson, J. McBain, 1992, Human reproduction.

A human CD2 minigene directs CRE‐mediated recombination in T cells in vivo

I. Kola, Dakang Xu, T. Wilson, 2002, Genesis.

Desrt, an AT-rich interaction domain family transcription factor gene, is an early marker for nephrogenic mesoderm and is expressed dynamically during mouse limb development

I. Kola, P. Tam, P. Hertzog, 2001, Mechanisms of Development.

Putting the rat on the map

I. Kola, 2004, Nature Biotechnology.

Decreased natural killer cell activity in endometriosis patients: relationship to disease pathogenesis.

E. C. Wood, I. Kola, T. Wilson, 1994, Fertility and sterility.

Fertilization of human oocytes by microinjection of a single spermatozoon under the zona pellucida.

I. Kola, A. Trounson, I Kola, 1987, Fertility and sterility.

Preimplantation embryo biopsy: Detection of trisomy in a single cell biopsied from a four‐cell mouse embryo

I. Kola, L. Wilton, 1991, Molecular reproduction and development.

Glutathione Peroxidase-1 Contributes to the Neuroprotection Seen in the Superoxide Dismutase-1 Transgenic Mouse in Response to Ischemia/Reperfusion Injury

I. Kola, J. D. de Haan, P. Hertzog, 2003, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Regulation of Rat Cytochrome P450C24 (CYP24) Gene Expression

D. Hume, I. Kola, B. May, 2000, The Journal of Biological Chemistry.

Thermolability of mouse oocytes is due to the lack of expression and/or inducibility of Hsp70

I. Kola, Jaqueline Hendrey, Ismail Kola, 1991, Molecular reproduction and development.

Transformation induced by Ewing's sarcoma associated EWS/FLI-1 is suppressed by KRAB/FLI-1

I. Kola, T. Wilson, P. Hertzog, 2003, British Journal of Cancer.

Ets2 is expressed during morphogenesis of the somite and limb in the mouse embryo

I. Kola, P. Tam, P. Hertzog, 2002, Mechanisms of Development.

Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis

I. Kola, E. Wolvetang, P. Hertzog, 2003, Neurobiology of Disease.

Tissue-specific overexpression of the HSA21 gene GABPalpha: implications for DS.

I. Kola, Dakang Xu, P. Hertzog, 2004, Biochimica et biophysica acta.

The corticotropin-release inhibitory factor hypothesis: a review of the evidence for the existence of inhibitory as well as stimulatory hypophysiotropic regulation of adrenocorticotropin secretion and biosynthesis.

I. Kola, E. Redei, I. Kola, 1999, Endocrine reviews.

Microinjection of in vitro transcribed RNA and antisense oligonucleotides in mouse oocytes and early embryos to study the gain- and loss-of-function of genes

I. Kola, S. Sumarsono, 1996, Molecular biotechnology.

Site-Specific Antiatherogenic Effect of the Antioxidant Ebselen in the Diabetic Apolipoprotein E–Deficient Mouse

I. Kola, M. Febbraio, J. D. de Haan, 2009, Arteriosclerosis, thrombosis, and vascular biology.