A. Hinck

发表

Three‐dimensional solution structure of the HIV‐1 protease complexed with DMP323, a novel cyclic urea‐type inhibitor, determined by nuclear magnetic resonance spectroscopy

T. Yamazaki, A. Hinck, Yun-Xing Wang, 1996, Protein science : a publication of the Protein Society.

The conserved adenosine in helix 6 of Archaeoglobus fulgidus signal recognition particle RNA initiates SRP assembly.

C. Zwieb, A. Hinck, O. Pakhomova, 2004, Archaea.

Crystal structure of the human TβR2 ectodomain–TGF-β3 complex

Shashank Deep, P. John Hart, A. Hinck, 2002, Nature Structural Biology.

CRYSTAL STRUCTURE OF THE HUMAN TBR2 ECTODOMAIN-TGF-B3 COMPLEX

A. Hinck, P. Hart, S. Deep, 2002 .

Structural Biology and Evolution of the TGF-β Family.

A. Hinck, T. Springer, T. Mueller, 2016, Cold Spring Harbor perspectives in biology.

Structural basis of J cochaperone binding and regulation of Hsp70.

A. Hinck, Alexander B. Taylor, R. Sousa, 2007, Molecular cell.

Engineered disulfide bonds in staphylococcal nuclease: effects on the stability and conformation of the folded protein.

A. Hinck, J. Markley, J. Markley, 1996, Biochemistry.

Structure-guided engineering of TGF-βs for the development of novel inhibitors and probing mechanism.

A. Hinck, 2018, Bioorganic & medicinal chemistry.

Distinct intramolecular interactions regulate autoinhibition of vinculin binding in αT-catenin and αE-catenin

A. Hinck, W. Weis, S. Kim, 2021, The Journal of biological chemistry.

Distinct autoinhibitory mechanisms regulate vinculin binding by αT-catenin and αE-catenin

A. Hinck, W. Weis, S. Kim, 2020 .

Structure Previews TGF-b Antagonists : Same Knot , but Different Hold

A. Hinck, Tao Huang, 2013 .

Full title: A Novel TGF-β Trap Blocks Chemotherapeutics-Induced TGF-β1 Signaling and Enhances Their Anticancer Activity in Gynecological Cancers

C. Zwieb, A. Hinck, Luzhe Sun, 2018 .

A Novel TGFβ Trap Blocks Chemotherapeutics-Induced TGFβ1 Signaling and Enhances Their Anticancer Activity in Gynecologic Cancers

C. Zwieb, A. Hinck, Luzhe Sun, 2018, Clinical Cancer Research.

Crystal structure of the human TbetaR2 ectodomain--TGF-beta3 complex.

A. Hinck, P. Hart, S. Deep, 2002, Nature structural biology.

Solution structure and backbone dynamics of the TGFbeta type II receptor extracellular domain.

A. Hinck, S. Deep, Zhanyong Shu, 2003, Biochemistry.

Convergent evolution of a parasite-encoded complement control protein-scaffold to mimic binding of mammalian TGF-β to its receptors, TβRI and TβRII

A. Hinck, C. Hinck, D. Smyth, 2022, The Journal of biological chemistry.

Structure-based mapping of the TβRI and TβRII receptor binding sites of the parasitic TGF-β mimic, Hp-TGM

A. Hinck, R. Maizels, C. Hinck, 2020, bioRxiv.

Structural biology of betaglycan and endoglin, membrane-bound co-receptors of the TGF-beta family

Morkos A. Henen, A. Hinck, S. Kim, 2019, Experimental biology and medicine.

Structural Adaptation in Its Orphan Domain Engenders Betaglycan with an Alternate Mode of Growth Factor Binding Relative to Endoglin.

Troy C. Krzysiak, C. Zwieb, A. Hinck, 2019, Structure.

Biological Activity Differences between TGF-β1 and TGF-β3 Correlate with Differences in the Rigidity and Arrangement of Their Component Monomers

A. Hinck, Tao Huang, S. Schor, 2014, Biochemistry.

TGF-β antagonists: same knot, but different hold.

A. Hinck, Tao Huang, 2013, Structure.

Three key residues underlie the differential affinity of the TGFbeta isoforms for the TGFbeta type II receptor.

A. Hinck, Luzhe Sun, M. O’Connor-McCourt, 2006, Journal of molecular biology.

Model-free analysis for large proteins at high magnetic field strengths

A. Hinck, R. Ishima, Shou-Lin Chang, 2007, Journal of biomolecular NMR.

Solution structure of protein SRP19 of Archaeoglobus fulgidus signal recognition particle.

C. Zwieb, A. Hinck, O. Pakhomova, 2002, Journal of molecular biology.

PHC3 SAM linker allows open-ended polymerization of PHC3 SAM

A. Hinck, Chongwoo A. Kim, B. Demeler, 2014 .

Structural transitions of the RING1B C-terminal region upon binding the polycomb cbox domain.

A. Hinck, Chongwoo A. Kim, E. Lafer, 2008, Biochemistry.

A. fulgidus SRP54 M-domain

C. Zwieb, A. Hinck, O. Pakhomova, 2008, Journal of biomolecular NMR.

Novel TGFβ Inhibitors Ameliorate Oral Squamous Cell Carcinoma Progression and Improve the Antitumor Immune Response of Anti–PD-L1 Immunotherapy

A. Hinck, T. Whiteside, C. Hinck, 2021, Molecular Cancer Therapeutics.

Crystal Structure of the Human TGF-beta Type II Receptor Extracellular Domain in Complex with TGF-beta3

A. Hinck, P. Hart, S. Deep, 2002 .

Letter to the Editor: Backbone sequential resonance assignments of yeast iso-2 cytochrome c, reduced and oxidized forms

A. Hinck, B. Nall, W. Ramos, 2002, Journal of biomolecular NMR.

An engineered TGF-β monomer that functions as a dominant negative to block TGF-β signaling

A. Hinck, T. Sulea, Alexander B. Taylor, 2019 .

Computational modeling of TGF-β2:TβRI:TβRII receptor complex assembly as mediated by the TGF-β co-receptor betaglycan

David M. Umulis, A. Hinck, D. Umulis, 2022, bioRxiv.

Class II cytokine common receptors: something old, something new.

A. Hinck, 2010, Structure.

Solvent Effects on the Energetics of Prolyl Peptide Bond Isomerization.

R. Raines, A. Hinck, S. Loh, 1992, Journal of the American Chemical Society.

TGF-β2 uses the concave surface of its extended finger region to bind betaglycan's ZP domain via three residues specific to TGF-β and inhibin-α

Troy C. Krzysiak, Morkos A. Henen, C. Zwieb, 2018, The Journal of Biological Chemistry.

Structure and dynamics of the homodimeric dynein light chain km23.

Borries Demeler, Wei Ding, A. Hinck, 2005, Journal of molecular biology.

Overexpression and purification of avian ovomucoid third domains in Escherichia coli.

A. Hinck, W. M. Westler, J. Markley, 1993, Protein engineering.

Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding.

A. Hinck, J. Wrana, C. Zubieta, 2008, Molecular cell.

D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2

R. Deberardinis, R. Aguiar, A. Hinck, 2015, Nature Communications.

Correction: A novel highly potent trivalent TGF-β receptor trap inhibits early-stage tumorigenesis and tumor cell invasion in murine Pten-deficient prostate glands

C. Zwieb, A. Hinck, Luzhe Sun, 2016, Oncotarget.

A novel highly potent trivalent TGF-β receptor trap inhibits early-stage tumorigenesis and tumor cell invasion in murine Pten-deficient prostate glands

C. Zwieb, A. Hinck, Luzhe Sun, 2016, Oncotarget.

Human polyhomeotic homolog 3 (PHC3) sterile alpha motif (SAM) linker allows open-ended polymerization of PHC3 SAM.

A. Hinck, Chongwoo A. Kim, B. Demeler, 2012, Biochemistry.

The Growth-Suppressive Function of the Polycomb Group Protein Polyhomeotic Is Mediated by Polymerization of Its Sterile Alpha Motif (SAM) Domain*

A. Hinck, P. Osmulski, M. Gaczynska, 2012, The Journal of Biological Chemistry.

Polycomb group targeting through different binding partners of RING1B C-terminal domain.

A. Hinck, P. Hart, Alexander B. Taylor, 2010, Structure.

Peptide ligands that use a novel binding site to target both TGF-β receptors.

A. Hinck, L. Kiessling, B. Orner, 2010, Molecular bioSystems.

Schistosoma mansoni: TGF-beta signaling pathways.

A. Hinck, P. LoVerde, A. Osman, 2007, Experimental parasitology.

The TβR-I pre-helix extension is structurally ordered in the unbound form and its flanking prolines are essential for binding.

A. Hinck, C. Hinck, D. G. McEwen, 2011, Journal of molecular biology.

TGFβ+ small extracellular vesicles from head and neck squamous cell carcinoma cells reprogram macrophages towards a pro‐angiogenic phenotype

A. Hinck, T. Ettl, T. Whiteside, 2022, Journal of extracellular vesicles.

Identification of nucleic acid binding residues in the FCS domain of the polycomb group protein polyhomeotic.

J. Berg, A. Hinck, Chongwoo A. Kim, 2011, Biochemistry.

TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition

A. Hinck, P. Chakravarty, G. Sapkota, 2018, eLife.

TGF‐β signalling is mediated by two autonomously functioning TβRI:TβRII pairs

A. Hinck, Luzhe Sun, J. Wrana, 2011, The EMBO journal.

Production, Isolation, and Structural Analysis of Ligands and Receptors of the TGF-β Superfamily.

A. Hinck, Tao Huang, 2016, Methods in molecular biology.

Kinetic, dynamic, ligand binding properties, and structural models of a dual-substrate specific nudix hydrolase from Schizosaccharomyces pombe.

L. D. Barnes, A. Hinck, J. A. Garza, 2009, Biochemistry.

Binding Affinity of Transforming Growth Factor-β for Its Type II Receptor Is Determined by the C-terminal Region of the Molecule*

M. Sporn, A. Hinck, A. Roberts, 1996, The Journal of Biological Chemistry.

A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells

A. Hinck, T. Le Bihan, A. Ivens, 2017, Nature Communications.

A structurally distinct immunosuppressive TGF-mimic from an intestinal helminth that potently induces murine and human regulatory T cells

A. Hinck, A. Ivens, R. Maizels, 2017 .

Structural basis for potency differences between GDF8 and GDF11

Richard T. Lee, A. Hinck, A. Wagers, 2017, BMC Biology.

Transforming growth factor beta 1: three-dimensional structure in solution and comparison with the X-ray structure of transforming growth factor beta 2.

M. Sporn, Bo Zhang, A. Hinck, 1996, Biochemistry.

Blockade of Autocrine TGF-β Signaling Inhibits Stem Cell Phenotype, Survival, and Metastasis of Murine Breast Cancer Cells.

A. Hinck, Luzhe Sun, Shui Wang, 2012, Journal of stem cell research & therapy.

Atomic resolution structures from fragmented protein crystals by the cryoEM method MicroED

David Eisenberg, Tamir Gonen, Michael R. Sawaya, 2017, Nature Methods.

Nuclear magnetic resonance mapping and functional confirmation of the collagen binding sites of matrix metalloproteinase-2.

A. Hinck, Xiaoping Xu, B. Steffensen, 2009, Biochemistry.

ALK1 signaling in development and disease: new paradigms

A. Hinck, B. L. Roman, 2017, Cellular and Molecular Life Sciences.

Schistosoma mansoni: TGF-β signaling pathways

A. Hinck, P. LoVerde, A. Osman, 2007 .

Assembly of TβRI: TβRII:TGFβ ternary complex in vitro with receptor extracellular domains is cooperative and isoform-dependent

A. Hinck, Luzhe Sun, O. Pakhomova, 2005 .

Assembly of TbetaRI:TbetaRII:TGFbeta ternary complex in vitro with receptor extracellular domains is cooperative and isoform-dependent.

A. Hinck, Luzhe Sun, O. Pakhomova, 2005, Journal of molecular biology.

Structural studies of the TGF‐βs and their receptors – insights into evolution of the TGF‐β superfamily

A. Hinck, 2012, FEBS letters.

TGF-b signalling is mediated by two autonomously functioning T b RI : T b RII pairs

A. Hinck, Luzhe Sun, J. Wrana, 2011 .

Ternary Complex of Transforming Growth Factor-β1 Reveals Isoform-specific Ligand Recognition and Receptor Recruitment in the Superfamily*

A. Hinck, P. Sun, Zhongcheng Zou, 2010, The Journal of Biological Chemistry.

Structure of the Alk1 extracellular domain and characterization of its bone morphogenetic protein (BMP) binding properties.

A. Hinck, Luzhe Sun, P. Mahlawat, 2012, Biochemistry.

TbetaR-II discriminates the high- and low-affinity TGF-beta isoforms via two hydrogen-bonded ion pairs.

Jason Baardsnes, A. Hinck, M. O’Connor-McCourt, 2009, Biochemistry.

An engineered transforming growth factor β (TGF-β) monomer that functions as a dominant negative to block TGF-β signaling

A. Hinck, T. Sulea, P. Hart, 2017, The Journal of Biological Chemistry.

Structures of TGF-β receptor complexes: implications for function and therapeutic intervention using ligand traps.

A. Hinck, M. O’Connor-McCourt, 2011, Current pharmaceutical biotechnology.

Binding Properties of the Transforming Growth Factor-β Coreceptor Betaglycan: Proposed Mechanism for Potentiation of Receptor Complex Assembly and Signaling

Troy C. Krzysiak, Morkos A. Henen, A. Hinck, 2016, Biochemistry.

Structure and role of BCOR PUFD in non-canonical PRC1 assembly and disease.

A. Hinck, Chongwoo A. Kim, V. Bardwell, 2020, Biochemistry.

Three Key Residues Underlie the Differential Affinity of the TGFβ Isoforms for the TGFβ Type II Receptor

Gregory De Crescenzo, Jason Baardsnes, A. Hinck, 2006 .

The solution structure of the regulatory domain of tyrosine hydroxylase.

A. Hinck, Shengnan Zhang, Tao Huang, 2014, Journal of molecular biology.

Characterization of ligand-binding properties of the human BMP type II receptor extracellular domain.

John C. Lee, A. Hinck, L. Yeh, 2008, Journal of molecular biology.

Dynamic interactions between clathrin and locally structured elements in a disordered protein mediate clathrin lattice assembly.

A. Hinck, R. Sousa, E. Lafer, 2010, Journal of molecular biology.

The Amino Acid Specificity for Activation of Phenylalanine Hydroxylase Matches the Specificity for Stabilization of Regulatory Domain Dimers

A. Hinck, Shengnan Zhang, P. Fitzpatrick, 2015, Biochemistry.

Two-dimensional NMR studies of staphylococcal nuclease. 2. Sequence-specific assignments of carbon-13 and nitrogen-15 signals from the nuclease H124L-thymidine 3',5'-bisphosphate-Ca2+ ternary complex.

A. Hinck, J. Markley, S. Loh, 1990, Biochemistry.

TGFBR3L is an inhibin B co-receptor that regulates female fertility

S. Sealfon, A. Hinck, Natalia Mendelev, 2021, Science advances.

Expression, purification and characterization of BG(E)RII: a novel pan-TGFbeta inhibitor.

A. Hinck, Luzhe Sun, Yuping Tang, 2008, Protein engineering, design & selection : PEDS.

Betaglycan has two independent domains required for high affinity TGF-beta binding: proteolytic cleavage separates the domains and inactivates the neutralizing activity of the soluble receptor.

A. Hinck, F. López‐Casillas, G. Mendoza-Hernández, 2009, Biochemistry.

Divergence(s) in nodal signaling between aggressive melanoma and embryonic stem cells

M. Hendrix, A. Hinck, D. Kirschmann, 2015, International journal of cancer.

Structural characterization of an activin class ternary receptor complex reveals a third paradigm for receptor specificity

A. Hinck, M. Matzuk, C. Hinck, 2019, Proceedings of the National Academy of Sciences.

Effects of amino acid substitutions on the pressure denaturation of staphylococcal nuclease as monitored by fluorescence and nuclear magnetic resonance spectroscopy.

A. Hinck, J. Markley, S. Loh, 1993, Biochemistry.

Characterization of hydride transfer to flavin adenine dinucleotide in neuronal nitric oxide synthase reductase domain: geometric relationship between the nicotinamide and isoalloxazine rings.

A. Hinck, R. T. Miller, 2001, Archives of biochemistry and biophysics.

TGFβ carrying exosomes in plasma: potential biomarkers of cancer progression in patients with head and neck squamous cell carcinoma

A. Hinck, T. Whiteside, C. Hinck, 2023, British Journal of Cancer.

Direct evidence for a phenylalanine site in the regulatory domain of phenylalanine hydroxylase.

A. Hinck, Jun Li, S. Daubner, 2011, Archives of biochemistry and biophysics.

The RNA binding domain of ribosomal protein L11: three-dimensional structure of the RNA-bound form of the protein and its interaction with 23 S rRNA.

S. Grzesiek, D. Draper, A. Hinck, 1997, Journal of molecular biology.

De novo design of BMP mimics.

A. Hinck, D. Baker, Xinru Wang, 2023, Biophysical journal.

Solution studies of staphylococcal nuclease H124L. 2. 1H, 13C, and 15N chemical shift assignments for the unligated enzyme and analysis of chemical shift changes that accompany formation of the nuclease-thymidine 3',5'-bisphosphate-calcium ternary complex.

A. Hinck, J. Markley, D. LeMaster, 1992, Biochemistry.

High resolution solution structure of ribosomal protein L11-C76, a helical protein with a flexible loop that becomes structured upon binding to RNA

D. Draper, A. Hinck, D. Torchia, 1997, Nature Structural Biology.

In search of "hepatic factor:" Lack of evidence for ALK1 ligands BMP9 and BMP10

A. Hinck, C. Hinck, B. L. Roman, 2020, medRxiv.

Characterization of the SRP68/72 interface of human signal recognition particle by systematic site‐directed mutagenesis

C. Zwieb, A. Hinck, C. Hinck, 2009, Protein science : a publication of the Protein Society.

Coupling between local structure and global stability of a protein: mutants of staphylococcal nuclease.

A. Hinck, J. Markley, A. Alexandrescu, 1990, Biochemistry.

Complexes with truncated RNAs from the large domain of Archaeoglobus fulgidus signal recognition particle.

C. Zwieb, A. Hinck, O. Pakhomova, 2001, FEMS microbiology letters.

Ternary structure of GDF11 bound to ActRIIB-ECD and Alk5-ECD

A. Hinck, M. Matzuk, C. Hinck, 2019 .

Letter to the Editor: Sequential resonance assignments of the extracellular ligand binding domain of the human TGF-β type II receptor

A. Hinck, S. Deep, C. Hinck, 2000 .

A novel highly potent trivalent TGF-β receptor trap inhibits early-stage tumorigenesis and tumor cell invasion in murine Pten-deficient prostate glands

C. Zwieb, A. Hinck, Luzhe Sun, 2016, Oncotarget.

Multiple-Quantum Line Narrowing for Measurement of H.alpha.-H.beta. J Couplings in Isotopically Enriched Proteins

S. Grzesiek, A. Bax, A. Hinck, 1995 .

Nuclear magnetic resonance mapping and functional confirmation of the collagen binding sites of matrix metalloproteinase-2.

A. Hinck, Xiaoping Xu, B. Steffensen, 2009, Biochemistry.

Shear stress and very low levels of ligand synergize to activate ALK1 signaling in endothelial cells

A. Hinck, C. Hinck, Anthony R. Anzell, 2023, bioRxiv.

Betaglycan has two independent domains required for high affinity TGF-beta binding: proteolytic cleavage separates the domains and inactivates the neutralizing activity of the soluble receptor.

A. Hinck, F. López‐Casillas, G. Mendoza-Hernández, 2009, Biochemistry.

Structural studies of the TGF‐βs and their receptors – insights into evolution of the TGF‐β superfamily

A. Hinck, 2012, FEBS letters.

The TβR-I pre-helix extension is structurally ordered in the unbound form and its flanking prolines are essential for binding.

A. Hinck, C. Hinck, D. G. McEwen, 2011, Journal of molecular biology.

Evaluation of competing J domain:Hsp70 complex models in light of existing mutational and NMR data

A. Hinck, Alexander B. Taylor, R. Sousa, 2011, Proceedings of the National Academy of Sciences.

Probing biomolecular structure, dynamics, and function using hydrogen exchange.

A. Hinck, 2022, Archives of biochemistry and biophysics.

Betaglycan sustains HGF/Met signaling in lung cancer and endothelial cells promoting cell migration and tumor growth

A. Hinck, C. Hinck, F. López‐Casillas, 2024, Heliyon.

Design of High Affinity Binders to Convex Protein Target Sites

Samer F. Halabiya, Stephen A. Rettie, A. Hinck, 2024, bioRxiv.

Shear Stress and Sub-Femtomolar Levels of Ligand Synergize to Activate ALK1 Signaling in Endothelial Cells

A. Hinck, C. Hinck, Lance A. Davidson, 2024, Cells.

An oncolytic virus–delivered TGFβ inhibitor overcomes the immunosuppressive tumor microenvironment

A. Hinck, C. Hinck, S. Thorne, 2023, The Journal of experimental medicine.

TGM6, a helminth secretory product, mimics TGF-β binding to TβRII to antagonize TGF-β signaling in fibroblasts

A. Hinck, C. Hinck, P. ten Dijke, 2023, bioRxiv.

An engineered transforming growth factor β (TGF-β) monomer that functions as a dominant negative to block TGF-β signaling

A. Hinck, T. Sulea, C. Hinck, 2017, The Journal of Biological Chemistry.

Letter to the Editor: Sequential resonance assignments of the extracellular domain of the human TGFβ type II receptor in complex with monomeric TGFβ3

A. Hinck, S. Deep, C. Hinck, 2004 .

Sequential resonance assignments of the extracellular domain of the human TGFbeta type II receptor in complex with monomeric TGFbeta3.

A. Hinck, S. Deep, C. Hinck, 2004, Journal of biomolecular NMR.

Sequential resonance assignments of the extracellular ligand binding domain of the human TGF-beta type II receptor.

A. Hinck, S. Deep, C. Hinck, 2000, Journal of biomolecular NMR.

Nuclear Magnetic Resonance Structural Mapping Reveals Promiscuous Interactions between Clathrin-Box Motif Sequences and the N-Terminal Domain of the Clathrin Heavy Chain

A. Hinck, R. Sousa, E. Lafer, 2015, Biochemistry.

CD44 acts as a coreceptor for cell-specific enhancement of signaling and regulatory T cell induction by TGM1, a parasite TGF-β mimic

A. Hinck, P. Dijke, C. Hinck, 2023, Proceedings of the National Academy of Sciences of the United States of America.