P. Jadhav

发表

Rational design of potent, bioavailable, nonpeptide cyclic ureas as HIV protease inhibitors.

PatrickY.-S. Lam, P. Lam, P. Jadhav, 1994, Science.

Flexibility and function in HIV-1 protease

Ad Bax, Peter J. Domaille, Chong-Hwan Chang, 1995, Nature Structural Biology.

Asymmetric carbon-carbon bond formation via .beta.-allyldiisopinocampheylborane. Simple synthesis of secondary homoallylic alcohols with excellent enantiomeric purities

P. Jadhav, H. Brown, 1983 .

Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450.

J L Meek, Chong-Hwan Chang, PatrickY.-S. Lam, 1996, Chemistry & biology.

An Assay for HIV RNA in Infected Cell Lysates, and its use for the Rapid Evaluation of Antiviral Efficacy

P. Jadhav, L. Bacheler, M. Otto, 1994 .

Stereoselective Synthesis of HIV-1 Protease Inhibitor, DMP 323.

P. Jadhav, L. Radesca, M. Pierce, 1996, The Journal of organic chemistry.

Copper-catalyzed general CN and CO bond cross-coupling with arylboronic acid

P. Lam, P. Jadhav, G. Vincent, 2001 .

αvβ3 Integrin Binding Affinity and Specificity of Sm256 in Various Species

P. Jadhav, S. Mousa, T. Reilly, 1999 .

Synthesis and biological evaluation of nonpeptide integrin antagonists containing spirocyclic scaffolds.

P. Jadhav, S. Mousa, C. Weigelt, 2004, Bioorganic & medicinal chemistry letters.

Improved P1/P1' substituents for cyclic urea based HIV-1 protease inhibitors: synthesis, structure-activity relationship, and X-ray crystal structure analysis.

Chong-Hwan Chang, P. Jadhav, L. Bacheler, 1997, Journal of medicinal chemistry.

B-Allyldiisocaranylborane: a new, remarkable enantioselective allylborating agent for prochiral aldehydes. Synthesis of homoallylic alcohols approaching 100% enantiomeric purities

P. Jadhav, H. Brown, 1984 .

Discovery of Cathepsin S Inhibitor LY3000328 for the Treatment of Abdominal Aortic Aneurysm.

Bruce W. Shaw, Michael A. Staszak, P. Jadhav, 2014, ACS medicinal chemistry letters.

Disubstituted Indazoles as Potent Antagonists of the Integrin αvβ3

P. J. Bouchard, P. Jadhav, S. Mousa, 2000 .

Isoxazolines as Potent Antagonists of the Integrin αvβ3

P. Jadhav, J. Wityak, S. Mousa, 2000 .

Rapid synthesis of RGD mimetics with isoxazoline scaffolds on solid phase: Identification of αvβ3 antagonists lead compounds

P. Jadhav, W. DeGrado, S. Mousa, 1999 .

Enantiomerically Pure Compounds via Chiral Organoboranes

P. Jadhav, H. Brown, Bakthan Singram, 1986 .

2-Chloro-4-[[(1R,2R)-2-hydroxy-2-methyl-cyclopentyl]amino]-3-methyl-benzonitrile: A Transdermal Selective Androgen Receptor Modulator (SARM) for Muscle Atrophy.

P. Jadhav, J. Luz, J. Henck, 2016, Journal of medicinal chemistry.

5-Amidinobenzo[b]thiophenes as dual inhibitors of factors IXa and Xa.

P. Jadhav, R. Knabb, D. Modi, 2005, Bioorganic & medicinal chemistry letters.

SAR and factor IXa crystal structure of a dual inhibitor of factors IXa and Xa.

P. Jadhav, R. Knabb, R. Alexander, 2004, Bioorganic & medicinal chemistry letters.

5-Amidinoindoles as dual inhibitors of coagulation factors IXa and Xa.

P. Jadhav, R. Knabb, D. Modi, 2004, Bioorganic & medicinal chemistry letters.

Chiral synthesis via organoboranes. 13. A highly diastereoselective and enantioselective addition of [(Z)-.gamma.-alkoxyallyl]diisopinocampheylboranes to aldehydes

P. Jadhav, H. Brown, K. Bhat, 1988 .

3,3-Dimethylallyldiisopinocampheylborane: a novel reagent for chiral isoprenylation of aldehydes. Synthesis of (+)- and (−)-artemisia alcohol in exceptionally high enantiomeric purity

P. Jadhav, H. Brown, 1984 .

Asymmetric methallylboration of prochiral aldehydes with methallyldiisopinocampheylborane·synthesis of 2-methyl-1-alken-4-ols in ≥ 90% enantiomeric purities

P. Jadhav, H. Brown, P. Perumal, 1984 .

Organoboranes—34 : General synthesis of chiral boronic and borinic esters via asymmetric hydroboration-displacement. carbenoidation of chiral borinic esters to acyclic ketones of high enantiomeric purities

P. Jadhav, M. Desai, H. Brown, 1984 .

Organoboranes. 27. Exploration of synthetic procedures for the preparation of monoisopinocampheylborane

P. Jadhav, H. Brown, N. Yoon, 1982 .

Hydroboration. 61. Diisopinocampheylborane of high optical purity. Improved preparation and asymmetric hydroboration of representative cis-disubstituted alkenes

P. Jadhav, M. Desai, H. Brown, 1982 .

Hydroboration. 62. Monoisopinocampheylborane; an excellent chiral hydroborating agent for trans-disubstituted and trisubstituted alkenes. Evidence for a strong steric dependence in such asymmetric hydroborations

P. Jadhav, H. Brown, A. Mandal, 1982 .

Direct chiral synthesis of boronic acids and esters of high optical purity via asymmetric hydroboration-displacement

P. Jadhav, M. Desai, H. Brown, 1982 .

Dilongifolylborane: a new effective chiral hydroborating agent with intermediate steric requirements

P. Jadhav, H. Brown, 1981 .

Monoisopinocampheylborane: an excellent chiral hydroborating agent for phenyl-substituted tertiary olefins. Synthesis of alcohols approaching 100% enantiomeric excess

P. Jadhav, H. Brown, A. Mandal, 1980 .

1 – Asymmetric Hydroboration

P. Jadhav, H. Brown, 1983 .

Asymmetric syntheses via chiral organoborane reagents

P. Jadhav, H. Brown, A. Mandal, 1981 .

Preparation and structure-activity relationship of novel P1/P1'-substituted cyclic urea-based human immunodeficiency virus type-1 protease inhibitors.

P. Jadhav, L. Bacheler, M. Rayner, 1996, Journal of medicinal chemistry.

Chiral synthesis via organoboranes. 6. Asymmetric allylboration via chiral allyldialkylboranes. Synthesis of homoallylic alcohols with exceptionally high enantiomeric excess

P. Jadhav, H. Brown, K. Bhat, 1986 .

An asymmetric synthesis of the diastereomeric 1-(2-cyclohexenyl)-1-alkanols in high optical purity via a stereochemically stable allylic borane, B-2-cyclohexen-1-yldiisopinocampheylborane

P. Jadhav, H. Brown, K. Bhat, 1985 .

P. Jadhav, H. Brown, A. Mandal, 1982 .

GENERAL SYNTHESIS OF CHIRAL BORINIC ACID ESTERS. ASYMMETRIC SYNTHESIS OF ACYCLIC KETONES VIA ASYMMETRIC HYDROBORATION-CARBENOIDATION

P. Jadhav, M. Desai, H. Brown, 1982 .

Hydroboration. 83. Synthesis and hydroboration of 2-ethylapopinene. Comparison of monoisopinocampheylborane and its 2-ethyl analog for the chiral hydroboration of representative alkenes

P. Jadhav, H. Brown, R. Randad, 1988 .

Synthesis of 8-membered cyclic sulfamides: Novel HIV-1 protease inhibitors

P. Jadhav, F. Woerner, 1995 .

Chiral synthesis via organoboranes. Part 32. Synthesis of B-(cycloalk-2-enyl)diisopinocampheylboranes of high enantiomeric purity via the asymmetric hydroboration of cycloalka-1,3-dienes. successful asymmetric allylborations of aldehydes with B-(cycloalk-2-enyl)diisopinocampheylboranes

P. Jadhav, H. Brown, K. Bhat, 1991 .

B-Allyldiisocaranylborane: a new, remarkable enantioselective allylborating agent for prochiral aldehydes. Synthesis of homoallylic alcohols approaching 100% enantiomeric purities

P. Jadhav, H. Brown, 1984 .

Synthesis of 7-membered cyclic oxamides: Novel HIV-1 protease inhibitors

P. Jadhav, H. Man, 1996 .

Chiral Synthesis via Organoboranes. Part 13. A Highly Diastereoselective and Enantioselective Addition of ((Z)-γ-Alkoxyallyl)diisopinocampheylboranes to Aldehydes.

P. Jadhav, H. Brown, K. Bhat, 1988 .

Potentially general synthesis of polyhyroxyindolizidines

P. Jadhav, F. Woerner, 1994 .

A convenient procedure for upgrading commercial (+)- and (-)-.alpha.-pinene to material of high optical purity

P. Jadhav, M. Desai, H. Brown, 1982 .

Remarkable optical induction in the reduction of .alpha.-oxo esters with B-(3-pinanyl)-9-borabicyclo[3.3.1]nonane. Synthesis of .alpha.-hydroxy esters of 100% optical purity

P. Jadhav, G. Pai, H. Brown, 1984 .

3,3-Bisaryloxindoles as mineralocorticoid receptor antagonists.

P. Jadhav, Matthew L. Brown, T. Grese, 2005, Bioorganic & medicinal chemistry letters.

Enantiotopic Differentiation of pro-R or pro-S Chlorides in (Dichloromethyl)borates by Chiral Lewis Acids: Enantioselective Synthesis of (α-Chloroalkyl)boronates

P. Jadhav, H. Man, 1997 .

Synthesis of cis and trans isomers of an isoxazoline ring-hydroxylated metabolite of roxifiban, a platelet glycoprotein IIb/IIIa receptor antagonist.

P. Jadhav, D. Batt, G. Houghton, 2000, The Journal of organic chemistry.

Cyclic HIV protease inhibitors: synthesis, conformational analysis, P2/P2' structure-activity relationship, and molecular recognition of cyclic ureas.

Chong-Hwan Chang, P. Lam, P. Jadhav, 1996, Journal of medicinal chemistry.

Novel hypoiodite functionalization of longifolol: Synthesis of longifol-7(15)-en-5β-ol and longifolan-3α, 7α-oxide-sesquiterpenes from juniperus conferta☆☆☆

P. Jadhav, U. Nayak, 1976 .

De novo design and discovery of cyclic HIV protease inhibitors capable of displacing the active-site structural water molecule.

PatrickY.-S. Lam, P. Lam, P. Jadhav, 2002 .

Synthesis of C2-symmetric HIV-1 protease inhibitors from D-mannitol

P. Jadhav, F. Woerner, 1992 .

(S)-N-{3-[1-cyclopropyl-1-(2,4-difluoro-phenyl)-ethyl]-1H-indol-7-yl}-methanesulfonamide: a potent, nonsteroidal, functional antagonist of the mineralocorticoid receptor.

G. Stephenson, P. Jadhav, T. Grese, 2007, Journal of medicinal chemistry.

Inhibition of Human Endogenous Retrovirus-K10 Protease in Cell-free and Cell-based Assays*

Chong-Hwan Chang, P. Jadhav, B. Korant, 2001, The Journal of Biological Chemistry.

Nonpeptide cyclic cyanoguanidines as HIV-1 protease inhibitors: synthesis, structure-activity relationships, and X-ray crystal structure studies.

J L Meek, P. Lam, P. Jadhav, 1998, Journal of medicinal chemistry.

The role of computer-aided and structure-based design techniques in the discovery and optimization of cyclic urea inhibitors of hiv protease

Chong-Hwan Chang, P. Jadhav, C. Eyermann, 1997 .

Molecular Recognition of Cyclic Urea HIV-1 Protease Inhibitors*

Chong-Hwan Chang, PatrickY.-S. Lam, P. Jadhav, 1998, The Journal of Biological Chemistry.

DMP 323, a nonpeptide cyclic urea inhibitor of human immunodeficiency virus (HIV) protease, specifically and persistently blocks intracellular processing of HIV gag polyprotein

P. Lam, P. Jadhav, Y. Ru, 1994, Antimicrobial Agents and Chemotherapy.

In vitro isolation and identification of human immunodeficiency virus (HIV) variants with reduced sensitivity to C-2 symmetrical inhibitors of HIV type 1 protease.

P. Jadhav, C. Hodge, M. Otto, 1993, Proceedings of the National Academy of Sciences of the United States of America.

ESR and X-ray Structure Investigations on the Binding and Mechanism of Inhibition of the Native State of Myeloperoxidase with Low Molecular Weight Fragments

P. Jadhav, D. Timm, W. Matter, 2015, Applied magnetic resonance.

Counteracting HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with XV638 and SD146, cyclic urea amides with broad specificities.

P. Lam, P. Jadhav, C. Chang, 1998, Biochemistry.

Cyclic urea amides: HIV-1 protease inhibitors with low nanomolar potency against both wild type and protease inhibitor resistant mutants of HIV.

P. Jadhav, L. Bacheler, C. Chang, 1997, Journal of medicinal chemistry.

Copper‐Catalyzed General C—N and C—O Bond Cross‐Coupling with Arylboronic Acid.

P. Lam, P. Jadhav, G. Vincent, 2001 .

Cyclic HIV protease inhibitors: design and synthesis of orally bioavailable, pyrazole P2/P2' cyclic ureas with improved potency.

P. Lam, P. Jadhav, Y. Ru, 1998, Journal of medicinal chemistry.

Asymmetric synthesis of (3R)-alkanoyloxytetradecanoic acids-components of bacterial lipopolysaccharides

P. Jadhav, 1989 .

Inhibition of neointima formation by a nonpeptide αvβ3 integrin receptor antagonist in a rabbit cuff model

P. Jadhav, T. Reilly, K. Schlingmann, 2000 .

Direct Synthesis of [alpha-[(tert-Butoxycarbonyl)amino]alkyl]- boronates from (alpha-Haloalkyl)boronates.

P. Jadhav, H. Man, 1996, The Journal of organic chemistry.