M. Otto

发表

Rational design of potent, bioavailable, nonpeptide cyclic ureas as HIV protease inhibitors.

PatrickY.-S. Lam, P. Lam, P. Jadhav, 1994, Science.

The site of attachment in human rhinovirus 14 for antiviral agents that inhibit uncoating.

G Vriend, M G Rossmann, M A McKinlay, 1986, Science.

The Mechanism of Action of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine Involves a Second Metabolic Pathway Leading to β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine 5′-Triphosphate, a Potent Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase

M. Otto, Haiying Bao, E. Murakami, 2007, Antimicrobial Agents and Chemotherapy.

Mechanism of Action of (-)-(2R,4R)-1-(2-hydroxymethyl-1,3-dioxolan-4-yl)thymine as an anti-HIV agent

Christopher M. Bailey, M. Otto, K. Anderson, 2007, Antiviral chemistry & chemotherapy.

Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450.

J L Meek, Chong-Hwan Chang, PatrickY.-S. Lam, 1996, Chemistry & biology.

An Assay for HIV RNA in Infected Cell Lysates, and its use for the Rapid Evaluation of Antiviral Efficacy

P. Jadhav, L. Bacheler, M. Otto, 1994 .

Discovery of PSI-353661, a Novel Purine Nucleotide Prodrug for the Treatment of HCV Infection.

M. Otto, C. Espiritu, A. Lam, 2011, ACS medicinal chemistry letters.

Inhibitors of the IMPDH Enzyme as Potential Anti-Bovine Viral Diarrhoea Virus Agents

M. Otto, L. Stuyver, S. Patterson, 2002, Antiviral chemistry & chemotherapy.

Dynamics of Subgenomic Hepatitis C Virus Replicon RNA Levels in Huh-7 Cells after Exposure to Nucleoside Antimetabolites

M. Otto, L. Stuyver, R. Schinazi, 2003, Journal of Virology.

Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl purine nucleosides as inhibitors of hepatitis C virus RNA replication.

M. Otto, L. Stuyver, R. Schinazi, 2006, Bioorganic & medicinal chemistry letters.

Inhibition of Human Hepatitis B Virus Replication by AT-61, a Phenylpropenamide Derivative, Alone and in Combination with (−)β-l-2′,3′-Dideoxy-3′-Thiacytidine

M. Otto, R. Perni, R. King, 1998, Antimicrobial Agents and Chemotherapy.

Phenylpropenamide derivatives as inhibitors of hepatitis B virus replication.

M. Otto, R. Perni, R. King, 2000, Bioorganic & medicinal chemistry letters.

Potent, selective and cell-mediated inhibition of human herpesvirus 6 at an early stage of viral replication by the non-nucleoside compound CMV423.

M. Otto, E. De Clercq, L. Naesens, 2004, Biochemical pharmacology.

Inhibition of Hepatitis C Replicon RNA Synthesis by β-D-2′-deoxy-2′-fluoro-2′-C-Methylcytidine: A Specific Inhibitor of Hepatitis C Virus Replication

M. Otto, L. Stuyver, R. Schinazi, 2006, Antiviral chemistry & chemotherapy.

SYNTHESIS OF N3,5′-CYCLO-4-(β-D-RIBOFURANOSYL)-VIC-TRIAZOLO[4,5-b]PYRIDIN-5-ONE AND ITS 3′-DEOXYSUGAR ANALOGUE AS POTENTIAL ANTI-HEPATITIS C VIRUS AGENTS

M. Otto, L. Stuyver, R. Schinazi, 2005, Nucleosides, nucleotides & nucleic acids.

SYNTHESIS AND ANTI-HEPATITIS C VIRUS ACTIVITY OF NUCLEOSIDE DERIVATIVES OF N 3,5′-ANHYDRO-4-(β-D-RIBOFURANOSYL)-8-AZAPURIN-2-ONES

M. Otto, L. Stuyver, R. Schinazi, 2005, Nucleosides, nucleotides & nucleic acids.

PSI-7851, a Pronucleotide of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication

M. Otto, D. Smee, C. Espiritu, 2010, Antimicrobial Agents and Chemotherapy.

Synthesis and Biological Activity of 5′,9-Anhydro-3-Purine-ISONucleosides as Potential Anti-Hepatitis C Virus Agents

M. Otto, L. Stuyver, R. Schinazi, 2007, Nucleosides, nucleotides & nucleic acids.

Inhibition of the Subgenomic Hepatitis C Virus Replicon in Huh-7 Cells by 2′-Deoxy-2′-Fluorocytidine

M. Otto, L. Stuyver, R. Schinazi, 2004, Antimicrobial Agents and Chemotherapy.

Ribonucleoside Analogue That Blocks Replication of Bovine Viral Diarrhea and Hepatitis C Viruses in Culture

M. Otto, L. Stuyver, R. Schinazi, 2003, Antimicrobial Agents and Chemotherapy.

Genotype and Subtype Profiling of PSI-7977 as a Nucleotide Inhibitor of Hepatitis C Virus

M. Otto, C. Espiritu, A. Lam, 2012, Antimicrobial Agents and Chemotherapy.

2-Chloro-3-pyridin-3-yl-5,6,7,8-tetrahydroindolizine-1-carboxamide (CMV423), a new lead compound for the treatment of human cytomegalovirus infections.

M. Otto, E. De Clercq, L. Naesens, 2002, Antiviral research.

Mechanism of Activation of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine and Inhibition of Hepatitis C Virus NS5B RNA Polymerase

M. Otto, L. Stuyver, R. Schinazi, 2007, Antimicrobial Agents and Chemotherapy.

Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication.

W. Stec, M. Otto, L. Stuyver, 2005, Journal of medicinal chemistry.

Synthesis and anti-HIV Activity of a Series of 2-Indolinones and Related Analogues

M. Otto, D. Montefiori, R. Earl, 1993 .

Synthesis and anti-HIV activity of pyrrolo-[1,2-d]-(1,4)-benzodiazepin-6-ones

M. Otto, G. D. Lucca, 1992 .

Inhibition of Hepatitis C Virus Replicon RNA Synthesis by PSI-352938, a Cyclic Phosphate Prodrug of β-d-2′-Deoxy-2′-α-Fluoro-2′-β-C-Methylguanosine

M. Otto, C. Espiritu, A. Lam, 2011, Antimicrobial Agents and Chemotherapy.

Inhibition of Hepatitis C Virus Replicon RNA Synthesis by PSI-352938, a Cyclic Phosphate Prodrug of (cid:1) - D -2 (cid:2) -Deoxy-2 (cid:2) - (cid:3) -Fluoro-2 (cid:2) - (cid:1) - C -Methylguanosine (cid:1) †

M. Otto, C. Espiritu, A. Lam, 2011 .

Effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine on synthesis of herpes simplex virus type 1-specific polypeptides

M. Otto, E. De Clercq, W. Prusoff, 1984, Antimicrobial Agents and Chemotherapy.

[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.

M. Otto, M. Mckinlay, G. Diana, 1985, Journal of medicinal chemistry.

Inducible expression of human hepatitis B virus (HBV) in stably transfected hepatoblastoma cells: a novel system for screening potential inhibitors of HBV replication

M. Otto, C. Barker, C. Seeger, 1997, Antimicrobial agents and chemotherapy.

PSI-7851, a Pronucleotide of (cid:1) - D -2 (cid:2) -Deoxy-2 (cid:2) -Fluoro-2 (cid:2) - C -Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication (cid:1)

M. Otto, D. Smee, C. Espiritu, 2010 .

N 4-Hydroxycytosine Dioxolane Nucleosides and Their Activity Against Hepatitis B Virus

M. Otto, L. Stuyver, R. Schinazi, 2005, Nucleosides, nucleotides & nucleic acids.

Synthesis and Antiviral Evaluation of 2′,3′-Dideoxy-2′-fluoro-3′-C-hydroxymethyl-β-D-arabinofuranosyl Pyrimidine Nucleosides

M. Otto, L. Stuyver, R. Schinazi, 2003, Nucleosides, nucleotides & nucleic acids.

N4-Acyl-Modified D-2′,3′-Dideoxy-5-Fluorocytidine Nucleoside Analogues with Improved Antiviral Activity

M. Otto, L. Stuyver, R. Schinazi, 2003, Antiviral chemistry & chemotherapy.

Inhibition of poliovirus uncoating by disoxaril (WIN 51711).

M. Otto, H. Zeichhardt, K. Habermehl, 1987, Virology.

In vitro activity of WIN 51711, a new broad-spectrum antipicornavirus drug

M. Otto, M. Mckinlay, G. Diana, 1985, Antimicrobial Agents and Chemotherapy.

Prevention of rhinovirus and poliovirus uncoating by WIN 51711, a new antiviral drug

M. Otto, M. Mckinlay, M. P. Fox, 1986, Antimicrobial Agents and Chemotherapy.

Overview of the Possible Targets for Viral Chemotherapy

M. Otto, W. Prusoff, Tai-shun Lin, 1984 .

In vitro and in vivo activities of WIN 54954, a new broad-spectrum antipicornavirus drug

M. Otto, M. Rogge, M. Mckinlay, 1989, Antimicrobial Agents and Chemotherapy.

Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977

M. Otto, C. Espiritu, A. Lam, 2010, The Journal of Biological Chemistry.

2'-deoxy-2'-α-fluoro-2'-β-C-methyl 3',5'-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: discovery of PSI-352938.

M. Otto, C. Espiritu, A. Lam, 2010, Bioorganic & medicinal chemistry letters.

Cytostatic 6-arylpurine nucleosides. 6. SAR in anti-HCV and cytostatic activity of extended series of 6-hetarylpurine ribonucleosides.

M. Otto, R. Pohl, Michal Hocek, 2005, Journal of medicinal chemistry.

Safety, Pharmacokinetics, and Efficacy of (+/−)-β-2′,3′-Dideoxy-5-Fluoro-3′-Thiacytidine with Efavirenz and Stavudine in Antiretroviral-Naïve Human Immunodeficiency Virus-Infected Patients

M. Otto, R. Schinazi, L. Cartee, 2005, Antimicrobial Agents and Chemotherapy.

Safety, pharmacokinetics, and efficacy of (+/-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine with efavirenz and stavudine in antiretroviral-naïve human immunodeficiency virus-infected patients.

M. Otto, R. Schinazi, L. Cartee, 2005, Antimicrobial agents and chemotherapy.

Activity and the metabolic activation pathway of the potent and selective hepatitis C virus pronucleotide inhibitor PSI-353661.

M. Otto, C. Espiritu, A. Lam, 2011, Antiviral research.

New nucleoside reverse transcriptase inhibitors for the treatment of HIV infections.

M. Otto, 2004, Current opinion in pharmacology.

HIV-1 Resistance Profile of the Novel Nucleoside Reverse Transcriptase Inhibitor β-D-2′,3′-Dideoxy-2′,3′-Didehydro-5-Fluorocytidine (Reverset™)

L. Bacheler, M. Otto, R. Schinazi, 2003, Antiviral chemistry & chemotherapy.

Antiviral Activity of Iodinated Pyrimidine Deoxyribonucleosides

M. Otto, B. Goz, William H. Prussof, 1984 .

Enantiomeric effects of homologues of disoxaril on the inhibitory activity against human rhinovirus-14.

A. Treasurywala, M. Rossmann, M. Otto, 1988, Journal of medicinal chemistry.

Inhibition of hepatitis C virus NS5A by fluoro-olefin based γ-turn mimetics.

M. Otto, A. Lam, M. Sofia, 2012, Bioorganic & medicinal chemistry letters.

Clevudine: a potent inhibitor of hepatitis B virus in vitro and in vivo

M. Otto, B. Korba, P. Furman, 2006, Expert review of anti-infective therapy.

The hepatitis B virus M539V polymerase variation responsible for 3TC resistance also confers cross-resistance to other nucleoside analogues.

M. Otto, R. King, S. Ladner, 1998, Antiviral chemistry & chemotherapy.

Phenylpropenamide derivatives: anti-hepatitis B virus activity of the Z isomer, SAR and the search for novel analogs.

M. Otto, M. Sofia, R. Mosley, 2011, Bioorganic & medicinal chemistry letters.

Phosphoramidate Prodrugs of (−)-β-D-(2R,4R)-dioxolane-thymine (DOT) as Potent Anti-HIV Agents

M. Otto, Véronique Zennou, M. Sofia, 2012, Antiviral chemistry & chemotherapy.

Comparative Pharmacokinetics of Racivir®, (±)-β-2′,3′-Dideoxy-5-Fluoro-3′-Thiacytidine in Rats, Rabbits, Dogs, Monkeys and HIV-Infected Humans

M. Otto, R. Schinazi, S. Hurwitz, 2005, Antiviral chemistry & chemotherapy.

Antiviral Activities and Cellular Toxicities of Modified 2′,3′-Dideoxy-2′,3′-Didehydrocytidine Analogues

M. Otto, L. Stuyver, R. Schinazi, 2002, Antimicrobial Agents and Chemotherapy.

Lamivudine-Resistant Viral Variants Activity against Zidovudine- and DPC 817: a Cytidine Nucleoside Analog with

M. Otto, M. Rayner, J. Mellors, 2014 .

Cellular Pharmacology of D-d4FC, a Nucleoside Analogue Active against Drug-Resistant HIV

M. Otto, R. Schinazi, R. Geleziunas, 2003, Antiviral chemistry & chemotherapy.

DPC 817: a Cytidine Nucleoside Analog with Activity against Zidovudine- and Lamivudine-Resistant Viral Variants

L. Bacheler, M. Otto, M. Rayner, 2002, Antimicrobial Agents and Chemotherapy.

Studies on Orally Available Inhibitors of HIV Protease. Peptidyl Aldehydes and Trifluoromethyl Ketones

C. Hodge, M. Otto, M. Rayner, 1994 .

Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activity.

M. Otto, L. Stuyver, R. Schinazi, 2004, Journal of medicinal chemistry.

Recent developments in antiviral chemotherapy.

M. Otto, M. Mckinlay, 1987, Infectious Disease Clinics of North America.

Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus.

M. Otto, C. Espiritu, A. Lam, 2010, Journal of medicinal chemistry.

Mechanism of Antiviral Activities of 3′-Substituted L-Nucleosides against 3Tc-Resistant HBV Polymerase: A Molecular Modelling Approach

M. Otto, L. Stuyver, R. Schinazi, 2003, Antiviral chemistry & chemotherapy.

The mechanism of action of beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine involves a second metabolic pathway leading to beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase.

M. Otto, Haiying Bao, E. Murakami, 2008, Antimicrobial agents and chemotherapy.

Safety, Pharmacokinetics, and Efﬁcacy of ( (cid:1) / (cid:2) )- (cid:3) -2 (cid:4) ,3 (cid:4) -Dideoxy-5-Fluoro-3 (cid:4) -Thiacytidine with Efavirenz and Stavudine in Antiretroviral-Naı¨ve Human Immunodeﬁciency Virus-Infected Patients

M. Otto, R. Schinazi, L. Cartee, 2005 .

SYNTHESIS AND IN VITRO ANTI-HCV ACTIVITY OF β-D- and L-2′-DEOXY-2′-FLUORORIBONUCLEOSIDES

M. Otto, L. Stuyver, R. Schinazi, 2005 .

Synthesis and anti-viral activity of a series of d- and l-2'-deoxy-2'-fluororibonucleosides in the subgenomic HCV replicon system.

M. Otto, L. Stuyver, R. Schinazi, 2005, Bioorganic & medicinal chemistry.

Synthesis and Antiviral Evaluation of 2′,3′-Dideoxy-2′-fluoro-3′-C-hydroxymethyl-β-D-arabinofuranosyl Pyrimidine Nucleosides

M. Otto, L. Stuyver, R. Schinazi, 2003, Nucleosides, nucleotides & nucleic acids.

Discovery of a β-D-2 0-Deoxy-2 0-r-fluoro-2 0-β-C-methyluridine Nucleotide Prodrug ( PSI-7977 ) for the Treatment of Hepatitis C Virus

M. Otto, C. Espiritu, A. Lam, 2010 .

Synthesis and anti-HCV activity of 3',4'-oxetane nucleosides.

M. Otto, M. Sofia, B. Ross, 2010, Bioorganic & medicinal chemistry letters.

Hepatitis C Virus Nucleotide Inhibitors PSI-352938 and PSI-353661 Exhibit a Novel Mechanism of Resistance Requiring Multiple Mutations within Replicon RNA

M. Otto, C. Espiritu, A. Lam, 2011, Journal of Virology.

β-D-2'-α-F-2'-β-C-Methyl-6-O-substituted 3',5'-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: a structure-activity relationship study.

M. Otto, C. Espiritu, A. Lam, 2012, Bioorganic & medicinal chemistry letters.

Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA

M. Otto, A. Lam, M. Sofia, 2012, Journal of Virology.

A rapid microtiter assay for duck hepatitis virus reverse transcriptase.

M. Otto, R. Whitaker, 2000, Methods in Molecular Medicine.

Discovery and Development of PSI‐6130/RG7128

M. Otto, M. Sofia, P. Furman, 2011 .

Synthesis and in vitro anti-HCV activity of beta-D- and 1-2'-deoxy-2'-fluororibonucleosides.

M. Otto, L. Stuyver, R. Schinazi, 2005, Nucleosides, Nucleotides & Nucleic Acids.

Physical and biological consequences of incorporation of antiviral agents into virus DNA.

M. Otto, W. Prusoff, T. Lin, 1984, Antiviral research.

Production of herpes simplex virus type 1 thymidine kinase in the presence of thymidine analogues.

M. Otto, W. Prusoff, M. Zucker, 1986, Antiviral research.

Basic biochemical and pharmacological aspects of antiviral agents.

M. Otto, W. Prusoff, T. Lin, 1985, Antiviral research.

Effects of nucleoside analogues on the expression of herpes simplex type 1-induced proteins.

M. Otto, W. Prusoff, J. J. Lee, 1982, Antiviral research.

The relationship between the antiviral activity of 5'-amino-5'-deoxythymidine and its incorporation into herpes simplex virus type 1 DNA.

M. Otto, W. Prusoff, 1984, Antiviral Research.

[590] INHIBITION OF HCV REPLICATION BY PSI-6130: MECHANISM OF BIOCHEMICAL ACTIVATION AND INHIBITION

M. Otto, J. Symons, Haiying Bao, 2007 .

Inhibition of Severe Acute Respiratory Syndrome-Associated Coronavirus (SARSCoV) by Calpain Inhibitors and β-D-N4-Hydroxycytidine

M. Otto, D. Smee, D. Barnard, 2004, Antiviral chemistry & chemotherapy.

Metabolic Activation of the Anti-Hepatitis C Virus Nucleotide Prodrug PSI-352938

M. Otto, A. Lam, M. Sofia, 2012, Antimicrobial Agents and Chemotherapy.

Molecular and Structural Basis for the Roles of Hepatitis C Virus Polymerase NS5B Amino Acids 15, 223, and 321 in Viral Replication and Drug Resistance

M. Otto, A. Lam, M. Sofia, 2014, Antimicrobial Agents and Chemotherapy.

Inhibition of the Subgenomic Hepatitis C Virus Replicon in Huh-7 Cells by 2 (cid:2) -Deoxy-2 (cid:2) -Fluorocytidine

M. Otto, L. Stuyver, R. Schinazi, 2004 .

In vitro anti-human immunodeficiency virus (HIV) activity of XM323, a novel HIV protease inhibitor

P. Lam, L. Bacheler, M. Otto, 1993, Antimicrobial Agents and Chemotherapy.

Enzymatic modifications of human fibroblast and leukocyte interferons

M. Otto, J. Sedmak, S. Grossberg, 1980, Journal of virology.

Synthesis and structure-activity relationships of novel anti-hepatitis C agents: N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one derivatives.

M. Otto, L. Stuyver, R. Schinazi, 2005, Journal of medicinal chemistry.

Inhibitors of viral uncoating.

M. Rossmann, M. Otto, T. Smith, 1989, Pharmacology & therapeutics.

Inhibitors of picornavirus uncoating as antiviral agents.

M. Otto, M. Mckinlay, G. Diana, 1985, Pharmacology & therapeutics.

The current standard of care for persons infected with HIV-1 is generally a combination of two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI) or a non-nucleoside reverse transcriptase inhibitor

L. Bacheler, M. Otto, R. Schinazi, 2003 .

Limited sequence diversity of the HIV type 1 protease gene from clinical isolates and in vitro susceptibility to HIV protease inhibitors.

M. Otto, D. Winslow, H. Scarnati, 1995, AIDS research and human retroviruses.

Multiple Mutations in the Human Immunodeficiency Virus Protease Gene Are Responsible for Decreased Susceptibility to Protease Inhibitors

L. Bacheler, M. Otto, D. Winslow, 1995 .

In vitro isolation and identification of human immunodeficiency virus (HIV) variants with reduced sensitivity to C-2 symmetrical inhibitors of HIV type 1 protease.

P. Jadhav, C. Hodge, M. Otto, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Identification of a clinical isolate of HIV-1 with an isoleucine at position 82 of the protease which retains susceptibility to protease inhibitors.

M. Otto, D. Winslow, H. Scarnati, 1995, Antiviral research.

the influence of the host cell on the inhibition of virus protein synthesis in cells double infected with vesicular stomatitis virus and mengovirus.

M. Otto, J. Lucas-Lenard, 1980, The Journal of general virology.

HIV protease inhibitors.

M. Otto, D. Winslow, 1995, AIDS.

Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating.

M. Otto, E. Maliski, J. Mallamo, 1987, Journal of Medicinal Chemistry.

Inhibition of Human Hepatitis B Virus Replication by AT-61, a Phenylpropenamide Derivative, Alone and in Combination with (−)β-l-2′,3′-Dideoxy-3′-Thiacytidine

M. Otto, R. Perni, R. King, 1999, Antimicrobial Agents and Chemotherapy.

In vitro susceptibility of clinical isolates of HIV‐1 to XM323, a non‐peptidyl HIV protease inhibitor

M. Otto, D. Winslow, D. Mayers, 1994, AIDS.