C. Schiffer

发表

Curling of flap tips in HIV-1 protease as a mechanism for substrate entry and tolerance of drug resistance.

W. Scott, C. Schiffer, Walter R. P. Scott, 2000, Structure.

Protein structure prediction with a combined solvation free energy-molecular mechanics force field

P. Kollman, R. Stroud, C. Schiffer, 1993 .

Computational design and experimental study of tighter binding peptides to an inactivated mutant of HIV‐1 protease

B. Tidor, C. Schiffer, M. Altman, 2008, Proteins.

Cooperative fluctuations of unliganded and substrate‐bound HIV‐1 protease: A structure‐based analysis on a variety of conformations from crystallography and molecular dynamics simulations

Turkan Haliloglu, Celia A Schiffer, W. Scott, 2003, Proteins.

Competition between Ski and CREB-binding Protein for Binding to Smad Proteins in Transforming Growth Factor-β Signaling*

C. Schiffer, S. Lam, Kai Lin, 2007, Journal of Biological Chemistry.

Promise of advances in simulation methods for protein crystallography: implicit solvent models, time-averaging refinement, and quantum mechanical modeling.

Jan Hermans, C. Schiffer, J. Hermans, 2003, Methods in enzymology.

The Proton Sponge: a Trick to Enter Cells the Viruses Did Not Exploit

Roland L. Dunbrack, M. Karplus, C. Schiffer, 1997, CHIMIA.

PTEN enters the nucleus by diffusion

C. Schiffer, A. Ross, J. Nickerson, 2005, Journal of cellular biochemistry.

First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G.

N. Krogan, C. Schiffer, R. Harris, 2012, ACS chemical biology.

Drug Resistance Conferred by Mutations Outside the Active Site through Alterations in the Dynamic and Structural Ensemble of HIV-1 Protease

C. Schiffer, Yufeng Cai, E. Nalivaika, 2014, Journal of the American Chemical Society.

Substrate shape determines specificity of recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes.

C. Schiffer, E. Nalivaika, M. Prabu-Jeyabalan, 2002, Structure.

Context Surrounding Processing Sites Is Crucial in Determining Cleavage Rate of a Subset of Processing Sites in HIV-1 Gag and Gag-Pro-Pol Polyprotein Precursors by Viral Protease*

C. Schiffer, Ayşegül Özen, R. Swanstrom, 2012, The Journal of Biological Chemistry.

Efficient Computation of Small-Molecule Configurational Binding Entropy and Free Energy Changes by Ensemble Enumeration

Bracken M. King, B. Tidor, C. Schiffer, 2013, Journal of chemical theory and computation.

Dengue Virus NS 2 B / NS 3 Protease Inhibitors Exploiting the Prime Side Authors

C. Schiffer, Akbar Ali, Kuan-Hung Lin, 2017 .

Dengue Virus NS2B/NS3 Protease Inhibitors Exploiting the Prime Side

C. Schiffer, Akbar Ali, Kuan-Hung Lin, 2017, Journal of Virology.

Lack of synergy for inhibitors targeting a multi‐drug‐resistant HIV‐1 protease

Celia A Schiffer, C. Schiffer, E. Nalivaika, 2002, Protein science : a publication of the Protein Society.

Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit

Mindy I. Davis, D. Baker, D. Hazuda, 2021, The Journal of infectious diseases.

Molecular Basis for Differential Patterns of Drug Resistance in Influenza N1 and N2 Neuraminidase.

Kelly M. Thayer, C. Schiffer, D. Bolon, 2016, Journal of chemical theory and computation.

T cell epitope engineering: an avian H7N9 influenza vaccine strategy for pandemic preparedness and response

C. Schiffer, A. D. De Groot, Hyesun Jang, 2018, Human vaccines & immunotherapeutics.

Accounting for molecular mobility in structure determination based on nuclear magnetic resonance spectroscopic and X-ray diffraction data.

C. Schiffer, W. V. van Gunsteren, W. V. Gunsteren, 1994, Methods in enzymology.

A comparative study of two different doses of cytarabine for acute myeloid leukemia: a phase III trial of Cancer and Leukemia Group B.

C. Schiffer, H. Preisler, R. Weiss, 1991, Blood.

HIV-1 Protease Inhibitors Incorporating Stereochemically Defined P2' Ligands to Optimize Hydrogen Bonding in the Substrate Envelope.

Nese Kurt Yilmaz, Celia A. Schiffer, Akbar Ali, 2019, Journal of medicinal chemistry.

Prototypical Recombinant Multi-Protease-Inhibitor-Resistant Infectious Molecular Clones of Human Immunodeficiency Virus Type 1

Tommy F. Liu, D. Katzenstein, R. Shafer, 2013, Antimicrobial Agents and Chemotherapy.

Structural basis and distal effects of Gag substrate coevolution in drug resistance to HIV-1 protease

C. Schiffer, Ayşegül Özen, Kuan-Hung Lin, 2014, Proceedings of the National Academy of Sciences.

The interdomain interface in bifunctional enzyme protein 3/4A (NS3/4A) regulates protease and helicase activities

Alicia M. Hanson, C. Schiffer, Cihan Aydın, 2013, Protein science : a publication of the Protein Society.

Drug-resistant HIV-1 protease regains functional dynamics through cleavage site coevolution

C. Schiffer, Ayşegül Özen, T. Haliloglu, 2015, Evolutionary applications.

Selection of HIV-1 for resistance to fifth-generation protease inhibitors reveals two independent pathways to high-level resistance

Shuntai Zhou, C. Schiffer, R. Swanstrom, 2019, bioRxiv.

Integrating Evolution of Drug Resistance into Drug Discovery

C. Schiffer, Ayşegül Özen, Ayşegül Özen, 2020 .

Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site.

R. Stroud, C. Schiffer, D. Santi, 1995, Biochemistry.

Point mutants of EHEC intimin that diminish Tir recognition and actin pedestal formation highlight a putative Tir binding pocket

C. Schiffer, J. Leong, P. Radhakrishnan, 2002, Molecular microbiology.

Nitric oxide-mediated inhibition of Hdm2-p53 binding.

Stephen N. Jones, C. Schiffer, A. Ross, 2002, Biochemistry.

Three Residues in HIV-1 Matrix Contribute to Protease Inhibitor Susceptibility and Replication Capacity

Deenan Pillay, Patricia A. Cane, C. Schiffer, 2010, Antimicrobial Agents and Chemotherapy.

Collinearity of protease mutations in HIV-1 samples with high-level protease inhibitor class resistance

Tommy F. Liu, R. Shafer, C. Schiffer, 2012, The Journal of antimicrobial chemotherapy.

NAD(H) phosphates mediate tetramer assembly of human C-terminal binding protein (CtBP)

C. Schiffer, W. Royer, J. C. Nichols, 2021, The Journal of biological chemistry.

Assembly of human C-terminal binding protein (CtBP) into tetramers

C. Schiffer, W. Royer, Janelle A. Hayes, 2018, The Journal of Biological Chemistry.

Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design

C. Schiffer, S. Grossman, W. Royer, 2014, FEBS letters.

Deciphering complex mechanisms of resistance and loss of potency through coupled molecular dynamics and machine learning

C. Schiffer, N. K. Yilmaz, F. Leidner, 2020, bioRxiv.

pM to µM - Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance.

Shuntai Zhou, C. Schiffer, D. Bolon, 2019, ACS chemical biology.

Structural Adaptation of Darunavir Analogs Against Primary Resistance Mutations in HIV-1 Protease

C. Schiffer, E. Nalivaika, Akbar Ali, 2018, bioRxiv.

Inhibiting HTLV-1 Protease: A Viable Antiviral Target.

C. Schiffer, E. Nalivaika, M. Somasundaran, 2021, ACS chemical biology.

Structural Determination of the Broadly Reactive Anti-IGHV 169 Anti-idiotypic Antibody G 6 and Its Idiotope Graphical

C. Schiffer, W. Marasco, T. Kowalik, 2018 .

Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope

L. Stamatatos, C. Schiffer, A. McGuire, 2017, Cell Reports.

Rationale for more diverse inhibitors in competition with substrates in HIV-1 protease.

C. Schiffer, T. Haliloglu, N. Ozer, 2010, Biophysical journal.

The impact of thrombopoietin and related Mpl-ligands on transfusion medicine.

C. Schiffer, A. Farese, T. MacVittie, 1997, Transfusion medicine reviews.

Simultaneous refinement of the structure of BPTI against NMR data measured in solution and X-ray diffraction data measured in single crystals.

R. Huber, K. Wüthrich, C. Schiffer, 1994, Journal of molecular biology.

Chemotherapy‐induced lactose intolerance in adults

H. Parnes, C. Schiffer, C. Schiffer, 1994, Cancer.

Therapeutic targeting of C-terminal binding protein in human cancer

C. Schiffer, S. Grossman, S. Lyle, 2010, Cell cycle.

Mass spectrometry analysis of HIV‐1 Vif reveals an increase in ordered structure upon oligomerization in regions necessary for viral infectivity

Jared R. Auclair, C. Schiffer, K. Green, 2007, Proteins.

Acute myeloid leukemia-type chemotherapy for newly diagnosed patients without antecedent cytopenias having myelodysplastic syndrome as defined by French-American-British criteria: a Cancer and Leukemia Group B Study.

C. Bloomfield, C. Schiffer, R. Mayer, 1996, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Substrate specificity in HIV‐1 protease by a biased sequence search method

C. Schiffer, T. Haliloglu, N. Ozer, 2006, Proteins.

Structural insights into neuronal K+ channel–calmodulin complexes

William R. Kobertz, C. Schiffer, W. R. Kobertz, 2012, Proceedings of the National Academy of Sciences.

Bacterial pattern recognition in C. elegans by a nuclear hormone receptor

C. Schiffer, R. Pukkila-Worley, Nicholas D. Peterson, 2022, bioRxiv.

Mucosal nanobody IgA as inhalable and affordable prophylactic and therapeutic treatment against SARS-CoV-2 and emerging variants

C. Schiffer, B. Pierce, A. Kruse, 2022, Frontiers in Immunology.

Structural basis for mutation-induced destabilization of profilin 1 in ALS

D. A. Bosco, C. Schiffer, J. Landers, 2015, Proceedings of the National Academy of Sciences.

Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state

C. Schiffer, H. Matsuo, J. Watts, 2022, bioRxiv.

Viability of a Drug-Resistant Human Immunodeficiency Virus Type 1 Protease Variant: Structural Insights for Better Antiviral Therapy

C. Schiffer, E. Nalivaika, N. King, 2003, Journal of Virology.

The Effect of Clade-Speciﬁc Sequence Polymorphisms on HIV-1 Protease Activity and Inhibitor Resistance Pathways (cid:1)

C. Schiffer, W. Sugiura, E. Nalivaika, 2010 .

Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond.

C. Schiffer, E. Nalivaika, Akbar Ali, 2021, Chemical reviews.

The Effect of Dexamethasone on Platelet Function

C. Schiffer, K. Lichtenfeld, 1979, Transfusion.

HIV-1 VIF and human APOBEC3G interaction directly observed through molecular specific labeling using a new dual promotor vector.

C. Schiffer, H. Matsuo, W. Myint, 2022, Journal of magnetic resonance.

Dual Inhibitors of Main Protease (MPro) and Cathepsin L as Potent Antivirals against SARS-CoV2

Jeong Min Lee, C. Schiffer, P. Thompson, 2022, Journal of the American Chemical Society.

Dengue Protease Substrate Recognition: Binding of the Prime Side.

C. Schiffer, E. Nalivaika, Kristina L. Prachanronarong, 2016, ACS infectious diseases.

Resistance outside the substrate envelope: hepatitis C NS3/4A protease inhibitors

C. Schiffer, Ayşegül Özen, Kristina L. Prachanronarong, 2019, Critical reviews in biochemistry and molecular biology.

PHAGE DISPLAY DERIVED VARIANT OF HUMAN GROWTH HORMONE COMPLEXED WITH TWO COPIES OF THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR

C. Schiffer, M. Ultsch, W. Somers, 2002 .

RecA dimers serve as a functional unit for assembly of active nucleoprotein filaments.

Michelle M. Kudron, C. Schiffer, K. Knight, 2006, Biochemistry.

Clinical evaluation of platelet concentrates stored for one to five days

Edward J. Lee, C. Schiffer, J. Reilly, 1986 .

The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors

Hong Cao, Christos J. Petropoulos, Celia A. Schiffer, 2012, PLoS pathogens.

Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance.

C. Schiffer, Akbar Ali, Adam K. Hedger, 2022, Journal of molecular biology.

Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance

C. Schiffer, D. Bolon, J. Flynn, 2022, Nature Communications.

Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance

C. Schiffer, E. Chan, Akbar Ali, 2021, bioRxiv.

Viral proteases: Structure, mechanism and inhibition

C. Schiffer, Nese Kurt Yilmaz, J. Zephyr, 2021, The Enzymes.

Discovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants.

C. Schiffer, C. Petropoulos, Wei Huang, 2021, Journal of medicinal chemistry.

Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors

C. Schiffer, Akbar Ali, Adam K. Hedger, 2020, mBio.

Molecular and structural mechanism of pan-genotypic HCV NS3/4A protease inhibition by glecaprevir [preprint]

C. Schiffer, Akbar Ali, M. Henes, 2020 .

Molecular and structural mechanism of pan-genotypic HCV NS3/4A protease inhibition by glecaprevir

C. Schiffer, Akbar Ali, Nese Kurt-Yilmaz, 2019, bioRxiv.

Resistance from Afar: Distal Mutation V36M Allosterically Modulates the Active Site to Accentuate Drug Resistance in HCV NS3/4A Protease

C. Schiffer, C. Petropoulos, Ayşegül Özen, 2018, bioRxiv.

Molecular Mechanism of Resistance in a Clinically Significant Double-Mutant Variant of HCV NS3/4A Protease.

C. Schiffer, C. Petropoulos, Wei Huang, 2018, Structure.

Quinoxaline-Based Linear HCV NS3/4A Protease Inhibitors Exhibit Potent Activity against Drug Resistant Variants.

C. Schiffer, C. Petropoulos, Wei Huang, 2018, ACS medicinal chemistry letters.

Hepatitis C Virus NS3/4A Protease Inhibitors Incorporating Flexible P2 Quinoxalines Target Drug Resistant Viral Variants.

Wei Huang, Akbar Ali, Celia A Schiffer, 2017, Journal of medicinal chemistry.

Interdependence of Inhibitor Recognition in HIV-1 Protease

C. Schiffer, Debra A. Ragland, J. Paulsen, 2017, Journal of chemical theory and computation.

Molecular and Dynamic Mechanism Underlying Drug Resistance in Genotype 3 Hepatitis C NS3/4A Protease.

C. Schiffer, Akbar Ali, Kristina L. Prachanronarong, 2016, Journal of the American Chemical Society.

Improving Viral Protease Inhibitors to Counter Drug Resistance.

C. Schiffer, R. Swanstrom, Nese Kurt Yilmaz, 2016, Trends in microbiology.

Structural and Thermodynamic Effects of Macrocyclization in HCV NS3/4A Inhibitor MK-5172.

C. Schiffer, Cihan Aydın, Akbar Ali, 2016, ACS chemical biology.

Improving Viral Protease Inhibitors to Counter Drug

C. Schiffer, R. Swanstrom, R. Yilmaz, 2016 .

Simultaneously Targeting the NS3 Protease and Helicase Activities for More Effective Hepatitis C Virus Therapy.

Akbar Ali, Kelin Li, Alicia M. Hanson, 2015, ACS chemical biology.

REdiii: a pipeline for automated structure solution.

Markus Frederik Bohn, Celia A Schiffer, C. Schiffer, 2015, Acta crystallographica. Section D, Biological crystallography.

Structural Analysis of Asunaprevir Resistance in HCV NS3/4A Protease

C. Schiffer, Akbar Ali, Djadé I. Soumana, 2014, ACS chemical biology.

Improving the Resistance Profile of Hepatitis C NS3/4A Inhibitors: Dynamic Substrate Envelope Guided Design.

C. Schiffer, W. Sherman, A. Ozen, 2013, Journal of chemical theory and computation.

Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance.

Hong Cao, Bruce Tidor, Nese Kurt Yilmaz, 2013, Chemistry & biology.

Evaluating the role of macrocycles in the susceptibility of hepatitis C virus NS3/4A protease inhibitors to drug resistance.

C. Schiffer, C. Petropoulos, Cihan Aydın, 2013, ACS chemical biology.

Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding

C. Schiffer, W. Royer, Akbar Ali, 2010, Proceedings of the National Academy of Sciences.

Evaluating the Substrate-Envelope Hypothesis: Structural Analysis of Novel HIV-1 Protease Inhibitors Designed To Be Robust against Drug Resistance

Michael K. Gilson, Hong Cao, Bruce Tidor, 2010, Journal of Virology.

High frequency of immunophenotype changes in acute myeloid leukemia at relapse: implications for residual disease detection (Cancer and Leukemia Group B Study 8361).

C. Bloomfield, C. Schiffer, R. Larson, 2001, Blood.

Remembering Professor Amy Christine Anderson

C. Schiffer, 2016 .

Genome scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes

D. Melton, C. Schiffer, Wei Zhang, 2020, Nature Metabolism.

Design of HIV-1 protease inhibitors active on multidrug-resistant virus.

Celia A Schiffer, Hilde Azijn, Rudi Pauwels, 2005, Journal of medicinal chemistry.

Stabilization of Type-I .beta.-Turn Conformations in Peptides Containing the NPNA-Repeat Motif of the Plasmodium falciparum Circumsporozoite Protein by Substituting Proline for (S)-.alpha.-Methylproline

John A. Robinson, C. Schiffer, W. F. Gunsteren, 1995 .

Structure-based design, synthesis, and structure-activity relationship studies of HIV-1 protease inhibitors incorporating phenyloxazolidinones.

Akbar Ali, Celia A Schiffer, Tariq M Rana, 2010, Journal of medicinal chemistry.

Design and synthesis of HIV-1 protease inhibitors incorporating oxazolidinones as P2/P2' ligands in pseudosymmetric dipeptide isosteres.

Akbar Ali, Celia A Schiffer, Tariq M Rana, 2007, Journal of medicinal chemistry.

A comparative study of two different doses of cytarabine for acute myeloid leukemia: a phase III trial of Cancer and Leukemia Group B.

C. Schiffer, H. Preisler, R. Weiss, 1991, Blood.

Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia

C. Bloomfield, C. Schiffer, S. George, 1994 .

Alloimmunization following platelet transfusion: the absence of a dose- response relationship

C. Schiffer, J. Dutcher, C. Schiffer, 1981 .

Crystal structure of the APOBEC3G catalytic domain reveals potential oligomerization interfaces.

C. Schiffer, H. Matsuo, E. Nalivaika, 2010, Structure.

Structural and Thermodynamic Basis for the Binding of TMC114, a Next-Generation Human Immunodeficiency Virus Type 1 Protease Inhibitor

Celia A. Schiffer, C. Schiffer, E. Nalivaika, 2004, Journal of Virology.

Viral Protease Inhibitors

C. Schiffer, R. Swanstrom, Sook-Kyung Lee, 2009, Handbook of experimental pharmacology.

Resilience to resistance of HIV-1 protease inhibitors: profile of darunavir.

Celia A Schiffer, C. Schiffer, Eric Lefebvre, 2008, AIDS reviews.

Methylcytosine and Normal Cytosine Deamination by the Foreign DNA Restriction Enzyme APOBEC3A*

C. Schiffer, Lela Lackey, M. Carpenter, 2012, The Journal of Biological Chemistry.

Influenza Virus Drug Resistance: A Time-Sampled Population Genetics Perspective

Daniel R. Caffrey, C. Schiffer, D. Bolon, 2014, PLoS genetics.

Evolution of the Influenza A Virus Genome during Development of Oseltamivir Resistance In Vitro

Alyssa J. Porter, Daniel R. Caffrey, C. Schiffer, 2013, Journal of Virology.

APOBEC3s: DNA‐editing human cytidine deaminases

C. Schiffer, Tania V. Silvas, 2019, Protein science : a publication of the Protein Society.

Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA

C. Schiffer, V. Pathak, H. Matsuo, 2018, Nature Communications.

Clinical significance of the BCR-ABL fusion gene in adult acute lymphoblastic leukemia: a Cancer and Leukemia Group B Study (8762).

C. Bloomfield, C. Schiffer, R. Larson, 1992, Blood.

Structural basis of substrate specificity in human cytidine deaminase family APOBEC3s

C. Schiffer, J. Lee, H. Matsuo, 2021, The Journal of biological chemistry.

CryoEM Structure of CtBP2 Confirms Tetrameric Architecture [preprint]

C. Schiffer, S. Grossman, W. Royer, 2021 .

Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations

C. Schiffer, M. Nussenzweig, P. Bieniasz, 2021, Immunity.

Morphologic characteristics of acute lymphoblastic leukemia (ALL) with abnormalities of chromosome 8, band q24

C. Bloomfield, C. Schiffer, M. L. Le Beau, 1992, American journal of hematology.

A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance.

Claudia Bank, Daniel R. Caffrey, Celia A Schiffer, 2016, Journal of molecular biology.

Cigarette smoking and risk of acute leukemia: associations with morphology and cytogenetic abnormalities in bone marrow.

C. Schiffer, R. Mayer, R. Silver, 1993, Journal of the National Cancer Institute.

High-dose intravenous gammaglobulin in alloimmunized platelet transfusion recipients

C. Schiffer, Ej Lee, J. Aisner, 1984 .

Target-Specific Prediction of Ligand Affinity with Structure-Based Interaction Fingerprints

Florian Leidner, Nese Kurt Yilmaz, Celia A. Schiffer, 2019, J. Chem. Inf. Model..

Value of immunophenotype in intensively treated adult acute lymphoblastic leukemia: cancer and leukemia Group B study 8364.

C. Bloomfield, M. Czuczman, C. Schiffer, 1999, Blood.

Comparison of psychosocial adaptation of advanced stage Hodgkin's disease and acute leukemia survivors. Cancer and Leukemia Group B.

J. Holland, C. Schiffer, D. Cella, 1998, Annals of oncology : official journal of the European Society for Medical Oncology.

CRISPR-Cas9–mediated saturated mutagenesis screen predicts clinical drug resistance with improved accuracy

Michael R. Green, C. Schiffer, D. Bolon, 2017, Proceedings of the National Academy of Sciences.

Inhibition of APOBEC3G activity impedes double‐stranded DNA repair

C. Schiffer, P. Prabhu, M. Kotler, 2016, The FEBS journal.

Crystal structure of a soluble APOBEC3G variant suggests ssDNA to bind in a channel that extends between the two domains.

C. Schiffer, V. Pathak, H. Matsuo, 2020, Journal of molecular biology.

Structure of the Vif-binding domain of the antiviral enzyme APOBEC3G

C. Schiffer, H. Matsuo, M. Shigematsu, 2015, Nature Structural &Molecular Biology.

Structure of a phage display-derived variant of human growth hormone complexed to two copies of the extracellular domain of its receptor: evidence for strong structural coupling between receptor binding sites.

C. Schiffer, M. Ultsch, A. D. de Vos, 2002, Journal of molecular biology.

Systematic analyses of the resistance potential of drugs targeting SARS-CoV-2 main protease

C. Schiffer, D. Bolon, J. Flynn, 2023, bioRxiv.

Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia.

C. Bloomfield, C. Schiffer, S. George, 1994, Blood.

The challenge of developing robust drugs to overcome resistance.

C. Schiffer, A. Anderson, N. Peet, 2011, Drug discovery today.

Structural Determination o f the Broadly Reactive Anti-IGHV 169 Anti-idiotypic Antibody G 6 and Its Idiotope Graphical Abstract Highlights

L. Stamatatos, C. Schiffer, A. McGuire, 2017 .

Use of surface marker analysis to predict outcome of adult acute myeloblastic leukemia.

C. Bloomfield, C. Schiffer, J. Griffin, 1986, Blood.

Introduction: Drug Resistance.

C. Schiffer, Nese Kurt Yilmaz, 2021, Chemical reviews.

Quantitative structural analysis of influenza virus by cryo-electron tomography and convolutional neural networks.

C. Schiffer, D. Bolon, R. Finberg, 2022, Structure.

Quantitative Structural Analysis of Influenza Virus by Cryo-electron Tomography and Convolutional Neural Networks

C. Schiffer, D. Bolon, R. Finberg, 2021, bioRxiv.

IgA MAb blocks SARS-CoV-2 Spike-ACE2 interaction providing mucosal immunity

C. Schiffer, M. Klempner, L. Cavacini, 2020, bioRxiv.

Covariation of amino acid positions in HIV-1 protease.

Celia A Schiffer, C. Schiffer, R. Swanstrom, 2003, Virology.

Call for Papers: Drug Resistance in Infectious Diseases and Beyond.

D. Hazuda, C. Schiffer, 2022, ACS infectious diseases.

Synonymous Mutations at the Beginning of the Influenza A Virus Hemagglutinin Gene Impact Experimental Fitness.

Daniel R. Caffrey, C. Schiffer, D. Bolon, 2018, Journal of molecular biology.

Unique structural solution from a VH3-30 antibody targeting the hemagglutinin stem of influenza A viruses

C. Schiffer, W. Marasco, R. Finberg, 2021, Nature Communications.

Mutations in Influenza A Virus Neuraminidase and Hemagglutinin Confer Resistance against a Broadly Neutralizing Hemagglutinin Stem Antibody

C. Schiffer, D. Bolon, W. Marasco, 2018, Journal of Virology.

The ineffectiveness of random donor platelet transfusion in splenectomized, alloimmunized recipients

C. Schiffer, J. Aisner, D. Hogge, 1984 .

Molecular Mechanisms of Viral and Host Cell Substrate Recognition by Hepatitis C Virus NS3/4A Protease

C. Schiffer, F. Massi, Laura M Deveau, 2011, Journal of Virology.

Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188

C. Schiffer, J. Lee, E. Nalivaika, 2021, Viruses.

A sensitive assay using a native protein substrate for screening HIV-1 maturation inhibitors targeting the protease cleavage site between the matrix and capsid.

C. Schiffer, W. Janzen, R. Swanstrom, 2013, Biochemistry.

Testing the Substrate-Envelope Hypothesis with Designed Pairs of Compounds

Hong Cao, Bruce Tidor, Celia A. Schiffer, 2013, ACS chemical biology.

Dynamics of preferential substrate recognition in HIV-1 protease: redefining the substrate envelope.

C. Schiffer, T. Haliloglu, A. Ozen, 2011, Journal of molecular biology.

Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5

C. Schiffer, J. Correia, S. Lam, 2008, Nature Structural &Molecular Biology.

Contribution of Ser386 and Ser396 to activation of interferon regulatory factor 3.

C. Schiffer, S. Lam, Kai Lin, 2008, Journal of molecular biology.

In Vitro Resistance Development of Oseltamivir Evolution of the Influenza A Virus Genome

Daniel R. Caffrey, C. Schiffer, D. Bolon, 2014 .

Constrained mutational sampling of amino acids in HIV-1 protease evolution

C. Schiffer, D. Bolon, T. Whitfield, 2018, bioRxiv.

Molecular mechanisms of viral and host-cell substrate recognition by HCV NS3/4A protease

C. Schiffer, F. Massi, Laura M Deveau, 2011 .

A computational analysis of the structural determinants of APOBEC3's catalytic activity and vulnerability to HIV-1 Vif.

C. Schiffer, M. Bohn, S. Shandilya, 2014, Virology.

Interactions of APOBEC3s with DNA and RNA.

C. Schiffer, H. Matsuo, A. Maiti, 2021, Current opinion in structural biology.

Non-canonical pattern recognition of a pathogen-derived metabolite by a nuclear hormone receptor identifies virulent bacteria in C. elegans.

C. Schiffer, K. Wani, R. Pukkila-Worley, 2023, Immunity.

Mutation Patterns and Structural Correlates in Human Immunodeficiency Virus Type 1 Protease following Different Protease Inhibitor Treatments

Thomas D. Wu, R. Shafer, C. Schiffer, 2003, Journal of Virology.

Cryo-EM Structure of CtBP2 Confirms Tetrameric Architecture.

C. Schiffer, S. Grossman, W. Royer, 2020, Structure.

CryoEM Structure of CtBP2 Confirms Tetrameric Architecture

C. Schiffer, S. Grossman, W. Royer, 2020, bioRxiv.

Structural stability of disulfide mutants of basic pancreatic trypsin inhibitor: A molecular dynamics study

C. Schiffer, W. V. van Gunsteren, Wilfred F. van Gunsteren, 1996, Proteins.

Investigation of protein unfolding and stability by computer simulation.

C. Schiffer, A. Mark, W. V. van Gunsteren, 1995, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Structure-based prediction of potential binding and nonbinding peptides to HIV-1 protease.

Turkan Haliloglu, Celia A Schiffer, C. Schiffer, 2003, Biophysical journal.

Development of potency, breadth and resilience to viral escape mutations in SARS-CoV-2 neutralizing antibodies

C. Schiffer, M. Nussenzweig, P. Bieniasz, 2021, bioRxiv.

Drug Resistance Mutations Alter Dynamics of Inhibitor-Bound HIV-1 Protease

C. Schiffer, Yufeng Cai, R. Ishima, 2014, Journal of chemical theory and computation.

Differential Flap Dynamics in Wild-type and a Drug Resistant Variant of HIV-1 Protease Revealed by Molecular Dynamics and NMR Relaxation.

C. Schiffer, Yufeng Cai, R. Ishima, 2012, Journal of chemical theory and computation.

Quantitative comparison of errors in 15N transverse relaxation rates measured using various CPMG phasing schemes

C. Schiffer, Yufeng Cai, R. Ishima, 2012, Journal of biomolecular NMR.

Investigations of peptide hydration using NMR and molecular dynamics simulations: A study of effects of water on the conformation and dynamics of antamanide

Jeffrey W. Peng, R. R. Ernst, C. Schiffer, 1996, Journal of biomolecular NMR.

Discovery of HIV-1 protease inhibitors with picomolar affinities incorporating N-aryl-oxazolidinone-5-carboxamides as novel P2 ligands.

Akbar Ali, Celia A Schiffer, Tariq M Rana, 2006, Journal of medicinal chemistry.

Replacement of the P1 Amino Acid of Human Immunodeficiency Virus Type 1 Gag Processing Sites Can Inhibit or Enhance the Rate of Cleavage by the Viral Protease

Celia A. Schiffer, C. Schiffer, S. Pettit, 2002, Journal of Virology.

Expression, purification, and characterization of thymidylate synthase from Lactococcus lactis

C. Schiffer, D. Santi, P. Greene, 1994, Protein science : a publication of the Protein Society.

Crystallization of human thymidylate synthase.

R. Stroud, C. Schiffer, D. Santi, 1991, Journal of molecular biology.

Robust against Drug Resistance HIV-1 Protease Inhibitors Designed To Be Hypothesis: Structural Analysis of Novel Evaluating the Substrate-Envelope

B. Tidor, M. Gilson, C. Schiffer, 2014 .

Structural and Thermodynamic Basis of Amprenavir/Darunavir and Atazanavir Resistance in HIV-1 Protease with Mutations at Residue 50

Celia A. Schiffer, C. Schiffer, E. Nalivaika, 2013, Journal of Virology.

Decomposing the energetic impact of drug-resistant mutations: the example of HIV-1 protease-DRV binding.

C. Schiffer, Yufeng Cai, 2012, Methods in molecular biology.

Crystal Structure of Lysine Sulfonamide Inhibitor Reveals the Displacement of the Conserved Flap Water Molecule in Human Immunodeficiency Virus Type 1 Protease

Celia A. Schiffer, Inge Dierynck, C. Schiffer, 2007, Journal of Virology.

Substrate Envelope and Drug Resistance: Crystal Structure of RO1 in Complex with Wild-Type Human Immunodeficiency Virus Type 1 Protease

Celia A. Schiffer, C. Schiffer, E. Nalivaika, 2006, Antimicrobial Agents and Chemotherapy.

Structural Basis for Coevolution of a Human Immunodeficiency Virus Type 1 Nucleocapsid-p1 Cleavage Site with a V82A Drug-Resistant Mutation in Viral Protease

Celia A. Schiffer, C. Schiffer, E. Nalivaika, 2004, Journal of Virology.

Molecular Basis for Drug Resistance in HIV-1 Protease

Celia A. Schiffer, Kelly M. Thayer, Akbar Ali, 2010, Viruses.

Association of a Novel Human Immunodeficiency Virus Type 1 Protease Substrate Cleft Mutation, L23I, with Protease Inhibitor Therapy and In Vitro Drug Resistance

T. Merigan, R. Shafer, C. Schiffer, 2004, Antimicrobial Agents and Chemotherapy.

HIV-1 Protease and Substrate Coevolution Validates the Substrate Envelope As the Substrate Recognition Pattern.

C. Schiffer, T. Haliloglu, A. Ozen, 2012, Journal of chemical theory and computation.

Human Immunodeficiency Virus Type 1 Protease-Correlated Cleavage Site Mutations Enhance Inhibitor Resistance

Celia A. Schiffer, Colombe Chappey, C. Schiffer, 2009, Journal of Virology.

Human Immunodeﬁciency Virus Type 1 Protease-Correlated Cleavage Site Mutations Enhance Inhibitor Resistance (cid:1) §

C. Schiffer, C. Chappey, E. Stawiski, 2009 .

Mechanism of Substrate Recognition by Drug-Resistant Human Immunodeficiency Virus Type 1 Protease Variants Revealed by a Novel Structural Intermediate

Celia A. Schiffer, C. Schiffer, E. Nalivaika, 2006, Journal of Virology.

Combating susceptibility to drug resistance: lessons from HIV-1 protease.

Celia A Schiffer, C. Schiffer, E. Nalivaika, 2004, Chemistry & biology.

The Role of Molecular Recognition in Activation and Regulation in the Growth Hormone-Prolactin Family of Hormones and Receptors

C. Schiffer, A. Kossiakoff, A. D. Vos, 1998 .

Positive Selection Drives Preferred Segment Combinations during Influenza Virus Reassortment.

Daniel R. Caffrey, C. Schiffer, D. Bolon, 2015, Molecular biology and evolution.

Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms

C. Schiffer, D. Bolon, J. Flynn, 2022, bioRxiv.

Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor.

Celia A Schiffer, Hilde Azijn, Rudi Pauwels, 2005, Journal of medicinal chemistry.

Toward the Design of Mutation‐Resistant Enzyme Inhibitors: Further Evaluation of the Substrate Envelope Hypothesis

Viney Lather, Michael K Gilson, Visvaldas Kairys, 2009, Chemical biology & drug design.

Accessibility and order of water sites in and around proteins: A crystallographic time‐averaging study

C. Schiffer, W. V. van Gunsteren, 1999, Proteins.

Time-averaging crystallographic refinement: possibilities and limitations using alpha-cyclodextrin as a test system.

C. Schiffer, W. V. van Gunsteren, P. Gros, 1995, Acta crystallographica. Section D, Biological crystallography.

A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction

C. Schiffer, M. Klempner, L. Cavacini, 2020, Nature Communications.

Mechanism for APOBEC3G catalytic exclusion of RNA and non-substrate DNA

C. Schiffer, H. Matsuo, R. Tripathi, 2019, Nucleic acids research.

COVID-19 Research

C. Schiffer, A. Khvorova, R. Finberg, 2020 .

HIV-1 Protease Uses Bi-Specific S2/S2’ Subsites To Optimize Cleavage of Two Classes of Target Sites

C. Schiffer, C. Carter, R. Swanstrom, 2018, bioRxiv.

Citrullination of NF-κB p65 promotes its nuclear localization and TLR-induced expression of IL-1β and TNFα

C. Schiffer, P. Thompson, I. Ho, 2017, Science Immunology.

Crystal structure of the DNA cytosine deaminase APOBEC3F: the catalytically active and HIV-1 Vif-binding domain.

C. Schiffer, M. Carpenter, A. Rathore, 2013, Structure.

Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode

C. Schiffer, J. Lee, E. Nalivaika, 2021, Biochemistry.

A Direct Interaction with RNA Dramatically Enhances the Catalytic Activity of the HIV-1 Protease In Vitro.

C. Schiffer, R. Swanstrom, E. Nalivaika, 2015, Journal of molecular biology.

Deciphering Complex Mechanisms of Resistance and Loss of Potency through Coupled Molecular Dynamics and Machine Learning.

C. Schiffer, Nese Kurt Yilmaz, F. Leidner, 2021, Journal of chemical theory and computation.

Decomposing the energetic impact of drug resistant mutations in HIV-1 protease on binding DRV.

Celia A Schiffer, Yufeng Cai, C. Schiffer, 2010, Journal of chemical theory and computation.

Mavyret: A Pan-Genotypic Combination Therapy for the Treatment of Hepatitis C InfectionPublished as part of the Biochemistry series "Biochemistry to Bedside".

C. Schiffer, Nese Kurt Yilmaz, A. N. Matthew, 2017, Biochemistry.

Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity

C. Schiffer, H. Matsuo, W. Royer, 2017, Nature Communications.

The role of protein-solvent interactions in protein unfolding.

C. Schiffer, V. Dötsch, Volker Dötsch, 1996, Current opinion in biotechnology.

Design of Mutation‐resistant HIV Protease Inhibitors with the Substrate Envelope Hypothesis

Hong Cao, Bruce Tidor, Michael K Gilson, 2007, Chemical biology & drug design.

N88D facilitates the co-occurrence of D30N and L90M and the development of multidrug resistance in HIV type 1 protease following nelfinavir treatment failure.

R. Shafer, C. Schiffer, M. Winters, 2006, AIDS research and human retroviruses.

Open Science Discovery of Potent Non-Covalent SARS-CoV-2 Main Protease Inhibitors

David D. L. Minh, Vincent A. Voelz, Matthew F. D. Hurley, 2023, bioRxiv.

Hydration Structure and Dynamics of Inhibitor-Bound HIV-1 Protease.

C. Schiffer, Y. Muller, J. Paulsen, 2018, Journal of chemical theory and computation.

Hydrophobic core flexibility modulates enzyme activity in HIV-1 protease.

Celia A Schiffer, Yufeng Cai, C. Schiffer, 2012, Journal of the American Chemical Society.

Extreme entropy-enthalpy compensation in a drug-resistant variant of HIV-1 protease.

Celia A Schiffer, C. Schiffer, Ayşegül Özen, 2012, ACS chemical biology.

Probing Structural Changes among Analogous Inhibitor-Bound Forms of HIV-1 Protease and a Drug-Resistant Mutant in Solution by Nuclear Magnetic Resonance.

C. Schiffer, R. Ishima, Nese Kurt-Yilmaz, 2018, Biochemistry.

Deciphering Antifungal Drug Resistance in Pneumocystis jirovecii DHFR with Molecular Dynamics and Machine Learning

Florian Leidner, Nese Kurt Yilmaz, Celia A. Schiffer, 2021, J. Chem. Inf. Model..

TMC310911, a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor, Shows In Vitro an Improved Resistance Profile and Higher Genetic Barrier to Resistance Compared with Current Protease Inhibitors

C. Schiffer, M.N.L. Nalam, T. Jonckers, 2011, Antimicrobial Agents and Chemotherapy.

Co-evolution of nelfinavir-resistant HIV-1 protease and the p1-p6 substrate.

Celia A Schiffer, C. Schiffer, M. Kolli, 2006, Virology.

Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance.

B. Tidor, C. Schiffer, T. Rana, 2012, Journal of medicinal chemistry.

Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease.

C. Schiffer, E. Nalivaika, Akbar Ali, 2018, ACS infectious diseases.

Exploring the role of the solvent in the denaturation of a protein: a molecular dynamics study of the DNA binding domain of the 434 repressor.

K Wüthrich, W F van Gunsteren, K. Wüthrich, 1995, Biochemistry.

The Effect of Clade-Specific Sequence Polymorphisms on HIV-1 Protease Activity and Inhibitor Resistance Pathways

C. Schiffer, W. Sugiura, E. Nalivaika, 2010, Journal of Virology.

New approaches to HIV protease inhibitor drug design II: testing the substrate envelope hypothesis to avoid drug resistance and discover robust inhibitors

Celia A. Schiffer, C. Schiffer, M.N.L. Nalam, 2008, Current opinion in HIV and AIDS.

The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization.

C. Schiffer, E. Nalivaika, S. Ryder, 2015, Structure.

Methyl-and Normal-Cytosine Deamination by the Foreign DNA Restriction Enzyme APOBEC 3 A

C. Schiffer, Lela Lackey, M. Carpenter, 2012 .

Structural analysis of the active site and DNA binding of human cytidine deaminase APOBEC3B

C. Schiffer, H. Matsuo, E. Nalivaika, 2018, bioRxiv.

Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions

C. Schiffer, H. Matsuo, E. Nalivaika, 2017, Scientific Reports.

Optimizing the refinement of merohedrally twinned P61 HIV-1 protease-inhibitor cocrystal structures.

C. Schiffer, W. Royer, Nese Kurt Yilmaz, 2020, Acta crystallographica. Section D, Structural biology.

Characterizing protein-ligand binding using atomistic simulation and machine learning: Application to drug resistance in HIV-1 protease.

Troy W Whitfield, Celia A Schiffer, Debra A Ragland, 2019, Journal of chemical theory and computation.

Elucidating the Interdependence of Drug Resistance from Combinations of Mutations.

C. Schiffer, T. Whitfield, R. Swanstrom, 2017, Journal of chemical theory and computation.

How does a symmetric dimer recognize an asymmetric substrate? A substrate complex of HIV-1 protease.

C. Schiffer, E. Nalivaika, C A Schiffer, 2000, Journal of molecular biology.

HIV-1 protease inhibitors from inverse design in the substrate envelope exhibit subnanomolar binding to drug-resistant variants.

Hong Cao, Bruce Tidor, Michael K Gilson, 2008, Journal of the American Chemical Society.

HIV-1 Protease-Substrate Coevolution in Nelfinavir Resistance

Celia A. Schiffer, C. Schiffer, Ayşegül Özen, 2014, Journal of Virology.

Evaluation of the substrate envelope hypothesis for inhibitors of HIV‐1 protease

Michael K Gilson, Visvaldas Kairys, Miguel X Fernandes, 2007, Proteins.

HIV-1 protease inhibitors with a P1 phosphonate modification maintain potency against drug-resistant variants by increased interactions with flap residues.

C. Schiffer, R. Swanstrom, E. Nalivaika, 2023, European journal of medicinal chemistry.

Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors Containing Bis-Tetrahydrofuran in a Pseudo-Symmetric Dipeptide Isostere.

C. Schiffer, R. Swanstrom, E. Nalivaika, 2020, Journal of medicinal chemistry.

Drug Resistance to HIV-1 Protease Inhibitors: Molecular Mechanisms and Substrate Coevolution

C. Schiffer, N. K. Yilmaz, 2017 .

Hydrophobic sliding: a possible mechanism for drug resistance in human immunodeficiency virus type 1 protease.

Celia A Schiffer, W. Scott, C. Schiffer, 2007, Structure.

Treatment by design in leukemia, a meeting report, Philadelphia, Pennsylvania, December 2002

F. E. Bertrand, G. Daley, C. Pui, 2003, Leukemia.

The effects of postinduction intensification treatment with cytarabine and daunorubicin in adult acute lymphocytic leukemia: a prospective randomized clinical trial by Cancer and Leukemia Group B.

C. Schiffer, E. Henderson, R. Silver, 1991, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

European LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia

C. Schiffer, R. Larson, M. Baccarani, 2020, Leukemia.

Phase IB study of the FLT3 kinase inhibitor midostaurin with chemotherapy in younger newly diagnosed adult patients with acute myeloid leukemia

C. Schiffer, H. Kantarjian, J. Cortes, 2012, Leukemia.

Molecular determinants of epistasis in HIV-1 protease: Elucidating the interdependence of L89V and L90M mutations in resistance.

C. Schiffer, D. Bolon, T. Whitfield, 2019, Biochemistry.

HIV-1 Protease-Substrate Coevolution in Nelﬁnavir Resistance

C. Schiffer, Nese Kurt-Yilmaz, M. Kolli, 2014 .

Extramedullary leukemia adversely affects hematologic complete remission rate and overall survival in patients with t(8;21)(q22;q22): results from Cancer and Leukemia Group B 8461.

C. Bloomfield, J. Byrd, M. Qumsiyeh, 1997, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Structural Analysis of Human Immunodeficiency Virus Type 1 CRF01_AE Protease in Complex with the Substrate p1-p6

C. Schiffer, W. Sugiura, R. Bandaranayake, 2008, Journal of Virology.

A randomized clinical trial comparing melphalan/prednisone with or without interferon alfa-2b in newly diagnosed patients with multiple myeloma: a Cancer and Leukemia Group B study.

C. Schiffer, K. Dear, C. Schiffer, 1993, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Effects of treatment with 5-azacytidine on the in vivo and in vitro hematopoiesis in patients with myelodysplastic syndromes.

C. Schiffer, B. Alter, J. Holland, 1993, Leukemia.

Acute myeloid leukemia with 11q23 translocations: myelomonocytic immunophenotype by multiparameter flow cytometry

C. Bloomfield, C. Schiffer, K. Mrózek, 1998, Leukemia.

NMR and MD studies combined to elucidate inhibitor and water interactions of HIV-1 protease and their modulations with resistance mutations

C. Schiffer, R. Ishima, Nese Kurt Yilmaz, 2019, Journal of Biomolecular NMR.

Introduction: Drug Resistance

C. Schiffer, Nese Kurt Yilmaz, 2021, Chemical Reviews.

Crystal Structures of Inhibitor-Bound Main Protease from Delta- and Gamma-Coronaviruses

C. Schiffer, S. Moquin, E. Ornelas, 2023, bioRxiv.

Role of Invariant Thr80 in Human Immunodeficiency Virus Type 1 Protease Structure, Function, and Viral Infectivity

C. Schiffer, R. Swanstrom, Gavin J. Henderson, 2006, Journal of Virology.

Crystal structure of the APOBEC3G catalytic domain

C. Schiffer, S. Shandilya, 2010 .

FruitFire: a luciferase based on a fruit fly metabolic enzyme

C. Schiffer, M. Bohn, S. Miller, 2023, bioRxiv.

Inclusion of solvation free energy with molecular mechanics energy: Alanyl dipeptide as a test case

R M Stroud, P A Kollman, P. Kollman, 1992, Protein science : a publication of the Protein Society.

Analyses of HIV proteases variants at the threshold of viability reveals relationships between processing efficiency and fitness

C. Schiffer, D. Bolon, J. Flynn, 2021, Virus evolution.

Additivity in the analysis and design of HIV protease inhibitors.

Bruce Tidor, Michael K Gilson, Akbar Ali, 2009, Journal of medicinal chemistry.

Cooperative effects of drug-resistance mutations in the flap region of HIV-1 protease.

R. Shafer, C. Schiffer, Nese Kurt Yilmaz, 2013, ACS chemical biology.

116 Deamination of both methyl- and normal-cytosine by the foreign DNA restriction enzyme APOBEC3A

C. Schiffer, Lela Lackey, M. Carpenter, 2013 .

Crystal structure of the APOBEC3G catalytic domain reveals potential oligomerization interfaces.

C. Schiffer, E. Nalivaika, Ming Li, 2010, Structure.

Identification of a Permissive Secondary Mutation That Restores the Enzymatic Activity of Oseltamivir Resistance Mutation H275Y

Ping Liu, C. Schiffer, W. Marasco, 2022, Journal of virology.

A computational analysis of the structural determinants of APOBEC3's catalytic activity and vulnerability to HIV-1 Vif.

C. Schiffer, M. Bohn, S. Shandilya, 2014, Virology.

Mutations in Influenza A Virus Neuraminidase and Hemagglutinin Confer Resistance against a Broadly Neutralizing Hemagglutinin Stem Antibody

C. Schiffer, W. Marasco, J. Jensen, 2018, Journal of Virology.

Structure-based design, synthesis, and structure-activity relationship studies of HIV-1 protease inhibitors incorporating phenyloxazolidinones.

C. Schiffer, T. Rana, S. Anjum, 2010, Journal of medicinal chemistry.

The challenge of developing robust drugs to overcome resistance.

C. Schiffer, A. Anderson, N. Peet, 2011, Drug Discovery Today.

New approaches to HIV protease inhibitor drug design II: testing the substrate envelope hypothesis to avoid drug resistance and discover robust inhibitors

C. Schiffer, M.N.L. Nalam, 2008, Current opinion in HIV and AIDS.

Combating Susceptibility to Drug ResistanceLessons from HIV-1 Protease

C. Schiffer, E. Nalivaika, N. King, 2004 .

First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G.

N. Krogan, C. Schiffer, M. Carpenter, 2012, ACS chemical biology.

Molecular and structural mechanism of pan-genotypic HCV NS3/ Molecular and structural mechanism of pan-genotypic HCV NS3/ 4A protease inhibition by glecaprevir [preprint] 4A protease inhibition by glecaprevir [preprint] us you.

C. Schiffer, Akbar Ali, M. Henes, 2022 .

The value of 10‐minute posttransfusion platelet counts

Edward J. Lee, C. Schiffer, C. Schiffer, 1988, Transfusion.

Single donor platelet transfusion.

C. Schiffer, 1985, Haematology and blood transfusion.

Structural basis for mutation-induced destabilization of profilin 1 in ALS

D. A. Bosco, C. Schiffer, J. Landers, 2015, Proceedings of the National Academy of Sciences.

Challenge of Alloimmunization and Refractoriness to Platelet Transfusion

C. Schiffer, 1997 .

Investigations of peptide hydration using NMR and molecular dynamics simulations: A study of effects of water on the conformation and dynamics of antamanide

Jeffrey W. Peng, R. R. Ernst, C. Schiffer, 1996, Journal of biomolecular NMR.

Improving Viral Protease Inhibitors to Counter Drug Resistance.

C. Schiffer, R. Swanstrom, Nese Kurt Yilmaz, 2016, Trends in Microbiology.

Structural basis and distal effects of Gag substrate coevolution in drug resistance to HIV-1 protease

C. Schiffer, Nese Kurt Yilmaz, Kuan‐Hung Lin, 2014, Proceedings of the National Academy of Sciences.

Evaluating the role of macrocycles in the susceptibility of hepatitis C virus NS3/4A protease inhibitors to drug resistance.

C. Schiffer, C. Petropoulos, Wei Huang, 2013, ACS chemical biology.

Structural and Thermodynamic Basis of Amprenavir/Darunavir and Atazanavir Resistance in HIV-1 Protease with Mutations at Residue 50

C. Schiffer, E. Nalivaika, M.N.L. Nalam, 2013, Journal of Virology.

Morphologic and cytochemical characteristics of acute promyelocytic leukemia

C. Bloomfield, C. Schiffer, J. Griffin, 1989, American journal of hematology.

Allosteric quinoxaline-based inhibitors of the flavivirus NS2B/NS3 protease.

C. Schiffer, E. Nalivaika, Akbar Ali, 2022, Bioorganic chemistry.

Structural and thermodynamic basis for the binding of TMC114, a Structural and thermodynamic basis for the binding of TMC114, a next-generation human immunodeficiency virus type 1 protease next-generation human immunodeficiency virus type 1 protease inhibitor inhibitor

C. Schiffer, E. Nalivaika, N. King, 2022 .

Antibody Fab Fragment

C. Schiffer, W. Marasco, Kristina L. Prachanronarong, 2017 .