J. Bigger

发表

Heart rate variability. Standards of measurement, physiological interpretation, and clinical use

A. Malliani, M. Malik, J. Bigger, 1996 .

Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology.

G. Breithardt, A. Camm, A. Malliani, 1996 .

Heart Rate Variability: Measurement and Clinical Utility

P. Stein, J. Bigger, R. Kleiger, 2005, Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc.

Stability over time of variables measuring heart rate variability in normal subjects.

M. Chung, J. Fleiss, J. Bigger, 1991, The American journal of cardiology.

Decreased heart rate variability and its association with increased mortality after acute myocardial infarction.

J. Miller, J. Bigger, R. Kleiger, 1987, The American journal of cardiology.

Analysis of prognostic significance of ventricular arrhythmias after myocardial infarction. Shortcomings of Lown grading system.

J. Bigger, F. M. Weld, 1981, British heart journal.

Effect of mental stress throughout the day on cardiac autonomic control

J. Gorman, J. Bigger, M. Paik, 1994, Biological Psychology.

Current Status of Direct Recordings of the Sinus Node Electrogram in Man

J. Bigger, J. Reiffel, 1983, Pacing and clinical electrophysiology : PACE.

Frequency Domain Measures of Heart Period Variability and Mortality After Myocardial Infarction

J. Fleiss, J. Bigger, R. Kleiger, 1992, Circulation.

Stability over time of heart period variability in patients with previous myocardial infarction and ventricular arrhythmias. The CAPS and ESVEM investigators.

J. Fleiss, J. Bigger, L. Rolnitzky, 1992, The American journal of cardiology.

Power law behavior of RR-interval variability in healthy middle-aged persons, patients with recent acute myocardial infarction, and patients with heart transplants.

J. Fleiss, J. Bigger, R. Cohen, 1996, Circulation.

Components of heart rate variability measured during healing of acute myocardial infarction.

J. Fleiss, J. Miller, J. Bigger, 1988, The American journal of cardiology.

RR variability in healthy, middle-aged persons compared with patients with chronic coronary heart disease or recent acute myocardial infarction.

J. Fleiss, P. Stein, J. Bigger, 1995, Circulation.

Observations on blood viscosity changes after acute myocardial infarction.

J. Bigger, K. Jan, S. Chien, 1975, Circulation.

"Protective" action of diphenylhydantoin on canine Purkinje fibers during hypoxia.

J. Bigger, B. Hoffman, A. Bassett, 1970, Journal of Pharmacology and Experimental Therapeutics.

Baroreflex Sensitivity and Heart Rate Variability in the Identification of Patients at Risk for Life-Threatening Arrhythmias: Implications for Clinical Trials

A J Camm, G D Pinna, A. Camm, 2001, Circulation.

Correlations among time and frequency domain measures of heart period variability two weeks after acute myocardial infarction.

J. Fleiss, J. Bigger, R. Kleiger, 1992, The American journal of cardiology.

Pharmacologic management of ventricular arrhythmias after the cardiac arrhythmia suppression trial.

J. Bigger, J. Morganroth, Jr Jt Bigger, 1990, The American journal of cardiology.

Baseline characteristics of patients in the coronary artery bypass graft (CABG) Patch Trial.

J. Bigger, D. Cannom, A. Curtis, 1997, American heart journal.

Risk stratification for coronary bypass surgery in patients with left ventricular dysfunction: analysis of the coronary artery bypass grafting patch trial database.

J. Bigger, H. Spotnitz, M. Argenziano, 1999, Circulation.

The Mechanism of Supraventricular Tachycardia

J. Bigger, B. N. Goldreyer, 1970, Circulation.

Issues in Subgroup Analyses and Meta‐Analyses of Clinical Trials

J. Bigger, 2003, Journal of cardiovascular electrophysiology.

Therapy of Cardiac Arrhythmias and Conduction Abnormalities in Coronary Artery Disease

J. Bigger, J. Reiffel, E. Leahey, 1985 .

Future studies with the implantable cardioverter defibrillator.

J. Bigger, 1991, Pacing and clinical electrophysiology : PACE.

Prophylactic Use of Implantable Cardioverter Defibrillators: Medical, Technical, Economic Considerations

J. Bigger, J. Bigger, 1991, Pacing and clinical electrophysiology : PACE.

Ultra low frequency power is the only power spectral measure not confounded by physical fitness

J. Bigger, R. Steinman, R. Goldsmith, 1996 .

Pure anterior conduction delay: a variant "fascicular" defect.

J. Bigger, J. Reiffel, 1978, Journal of electrocardiology.

Autonomic nervous system activity during myocardial ischemia in man estimated by power spectral analysis of heart period variability

J. Fleiss, J. Bigger, L. Rolnitzky, 1990 .

Electrophysiological and Beta‐Receptor Blocking Effects of MJ 1999 on Dog and Rabbit Cardiac Tissue

J. Bigger, H. Strauss, B. Hoffman, 1970, Circulation research.

A physiologically based model of creatine kinase-MB release in reperfusion of acute myocardial infarction.

J. Bigger, J. Coromilas, V. Padmanabhan, 1989, The American journal of cardiology.

Measurement of infarct size and percentage myocardium infarcted in a dog preparation with single photon-emission computed tomography, thallium-201, and indium 111-monoclonal antimyosin Fab.

J. Bigger, J. Coromilas, L. Johnson, 1987, Circulation.

Epidemiological and mechanistic studies of atrial fibrillation as a basis for treatment strategies.

J. Bigger, 1998, Circulation.

Why patients with congestive heart failure die: arrhythmias and sudden cardiac death.

J. Bigger, 1987, Circulation.

The quinidine--digoxin interaction.

J. Bigger, 1981, International journal of cardiology.

Detection and Significance of Myocardial Ischemia in Stable Patients after Recovery from an Acute Coronary Event

J. Fleiss, K. Freedland, L. Kuller, 1993 .

Follow‐up Studies of Acute Dissecting Aortic Aneurysms Managed with Antihypertensive Agents

J. Bigger, F. Bowman, J. Malm, 1967, Circulation.

Detection and significance of myocardial ischemia in stable patients after recovery from an acute coronary event. Multicenter Myocardial Ischemia Research Group.

J. Fleiss, J. Bigger, A. Moss, 1993, JAMA.

AHA science advisory. Depression and coronary heart disease. Recommendations for screening, referral, and treatment. A science advisory from the American Heart Association Prevention Committee to the Council on Cardiovascular Nursing, Council on Clinical Cardiology, Council on Epidemiology and Preve

D. Mark, J. Bigger, P. Kaufmann, 2009, Progress in cardiovascular nursing.

Implications of the Cardiac Arrhythmia Suppression Trial for antiarrhythmic drug treatment.

J. Bigger, 1990, The American journal of cardiology.

AMBULATORY ECG ANALYSIS SHARED BY TWO INDEPENDENT COMPUTER LABS IN THE MULTICENTER POST-INFARCTION PROGRAM (MPIP).

Kenneth W. Clark, J. T. Bigger, K. W. Clark, 1980 .

Long-term continuous electrocardiographic recordings and electrophysiologic testing to select patients with ventricular arrhythmias for drug trials and to determine antiarrhythmic drug efficacy.

J. Bigger, 1986, The American journal of cardiology.

Holter/Exercise and Electrophysiologic Methods for Evaluating Drug Therapy for Malignant Ventricular Arrhythmias: Do We Need Both Models?

J. Bigger, 1985 .

Prognostic significance of ventricular premature depolarizations measured 1 year after myocardial infarction in patients with early postinfarction asymptomatic ventricular arrhythmia.

J. Bigger, D. Roden, A. Waldo, 1992, Journal of the American College of Cardiology.

NEW DRUGS.

J. Bigger, R. H. Heissenbuttel, 1979, Canadian Medical Association journal.

Relation between left ventricular dysfunction and ventricular arrhythmias after myocardial infarction.

J. Bigger, 1986, The American journal of cardiology.

Electrophysiological Properties of the Rabbit Sinoatrial Perinodal Fibers

J. Bigger, H. Strauss, C., 1972, Circulation research.

How do beta-blockers protect after myocardial infarction?

J. Bigger, J. Coromilas, 1984, Annals of internal medicine.

The use of procaine amide and lidocaine in the treatment of cardiac arrhythmias.

J. Bigger, R. H. Heissenbuttel, 1969, Progress in cardiovascular diseases.

Effect of lidocaine on conduction in canine Purkinje fibers and at the ventricular muscle-Purkinje fiber junction.

J. Bigger, W. Mandel, 1970, The Journal of pharmacology and experimental therapeutics.

Possible Electrophysiological Mechanisms for Lethal Arrhythmias Accompanying Myocardial Ischemia and Infarction

J. Bigger, A. L. Wit, 1975, Circulation.

Influence of wall motion score on mortality after coronary bypass surgery in the CABG-patch trial.

J. Bigger, D. Cannom, J. Dimarco, 2002, International journal of cardiology.

Effects of digoxin on sinus nodal function before and after vagal blockade in patients with sinus nodal dysfunction: a clue to the mechanisms of the action of digitalis on the sinus node.

J. Bigger, J. Reiffel, M. Cramer, 1979, The American journal of cardiology.

The Relationship Between Sinoatrial Conduction Time and Sinus Cycle Length During Spontaneous Sinus Arrhythmia in Adults

J. Bigger, M. Konstam, J. Reiffel, 1974, Circulation.

A summary and assessment of the findings and conclusions of the ESVEM trial.

J. Bigger, J. Mason, R. Lazzara, 1996, Progress in cardiovascular diseases.

The potential for antiarrhythmic drugs to reduce mortality from sudden cardiac death

J. Bigger, 1991 .

The ESVEM Trial: Electrophysiologic Study Versus Electrocardiographic Monitoring for Selection of Antiarrhythmic Therapy of Ventricular Tachyarrhythmias

Jeffrey L. Anderson, J. Bigger, J. Mason, 1989, Circulation.

Patients with malignant or potentially malignant ventricular arrhythmias: opportunities and limitations of drug therapy in prevention of sudden death.

J. Bigger, 1985, Journal of the American College of Cardiology.

Perspectives on the current treatment of cardiac arrhythmias.

J. Bigger, 1984, The American journal of cardiology.

Long-term carvedilol therapy increases parasympathetic nervous system activity in chronic congestive heart failure.

J. Bigger, H. Krum, R. Steinman, 1997, The American journal of cardiology.

The effect of atropine on sinus node function in adults with sinus bradycardia

J. Bigger, D. Reid, J. Reiffel, 1975 .

The independence of cycle length variability and exercise testing on predicting mortality of patients surviving acute myocardial infarction. The Multicenter Postinfarction Research Group.

J. Miller, J. Bigger, R. Kleiger, 1990, The American journal of cardiology.

Nonfatal myocardial infarction is, by itself, an inappropriate end point in clinical trials in cardiology.

T. Therneau, J. Fleiss, J. Miller, 1990, Circulation.

Digitalis Toxicity

J. Bigger, 1985, Journal of clinical pharmacology.

Prognosis after recovery from acute myocardial infarction.

J. Bigger, L. Rolnitzky, J. Coromilas, 1984, Annual review of medicine.

Limitations of the Lown grading system for study of human ventricular arrhythmias.

J. Bigger, T. Wenger, R. H. Heissenbuttel, 1977, American heart journal.

The variability of spontaneous ventricular arrhythmias in the year after myocardial infarction.

J. Fleiss, J. Bigger, 1991, Journal of the American College of Cardiology.

The events surrounding the removal of encainide and flecainide from the Cardiac Arrhythmia Suppression Trial (CAST) and why CAST is continuing with moricizine.

J. Bigger, 1990, Journal of the American College of Cardiology.

Spontaneous and induced reentrant tachycardia.

J. Bigger, B. N. Goldreyer, 1969, Annals of internal medicine.

The Effect of Procaine Amide on Components of Excitability in Long Mammalian Cardiac Purkinje Fibers

J. Bigger, M. Arnsdorf, 1976, Circulation research.

Cardiac electrophysiologic effects of moricizine hydrochloride.

J. Bigger, 1990, The American journal of cardiology.

Sensitivity, specificity, and reproducibility of programmed ventricular stimulation.

P. J. Wang, J. Bigger, J. Reiffel, 1986, Circulation.

Protecting Subjects, Preserving Trust, Promoting Progress II: Principles and Recommendations for Oversight of an Institution's Financial Interests in Human Subjects Research

Director, F. Davidoff, J. Bigger, 2003, Academic medicine : journal of the Association of American Medical Colleges.

The effect of oral quinidine on intraventricular conduction in man: correlation of plasma quinidine with changes in QRS duration.

J. Bigger, R. H. Heissenbuttel, 1970, American heart journal.

Effect of Atrial Tachyarrhythmias and Atrial Pacing on Supraventricular Tissues

J. Bigger, 1984, Pacing and clinical electrophysiology : PACE.

Ventricular Tachyarrhythmias in the Various Stages of Ischemic Heart Disease

J. Bigger, J. Coromilas, 1984 .

Metabolism of procainamide in normal and cardiac subjects

J. Bigger, E. Schreiber, J. Dreyfuss, 1976, Clinical pharmacology and therapeutics.

New directions and new uses for risk stratification in the posthospital phase of acute myocardial infarction.

J. Bigger, 1979, The American journal of medicine.

Electrophysiologic testing in patients with recurrent syncope: are results predicted by prior ambulatory monitoring?

J. Bigger, K. Ferrick, J. Reiffel, 1985, American heart journal.

Mechanisms of Quinidine‐Induced Depression of Maximum Upstroke Velocity in Ovine Cardiac Purkinje Fibers

J. Bigger, J. Rottman, J. Coromilas, 1982, Circulation research.

Angina pectoris early after myocardial infarction: clinical experience of the multicentre post-infarction program.

J. Bigger, 1986, European heart journal.

Effect of surgical revascularization in patients with coronary artery disease and ventricular tachycardia or fibrillation in the Antiarrhythmics Versus Implantable Defibrillators (AVID) Registry.

Judy Powell, James Coromilas, J Thomas Bigger, 2002, American heart journal.

Women, but not men, have prolonged QT interval if depressed after an acute coronary syndrome.

J. Bigger, H. Garan, K. Davidson, 2012, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

Electrocardiology and Risk Stratification Women , but not men , have prolonged QT interval if depressed after an acute coronary syndrome

J. Bigger, H. Garan, K. Davidson, 2012 .

Quinidine toxicity: An electrophysiological evaluation in cardiac purkinje fibers

J. Bigger, J. Rottman, F. M. Weld, 1980 .

Effects of imipramine hydrochloride on electrophysiological roperties of sheep cardiac Purkinje fibers

J. Bigger, F. M. Weld, D. Swistel, 1978 .

--ting Mortafit) After Myocardli 1 W? - AR 1ty ho Anflarrhythmic Dir ug'fhnn- - ,y

J. Fleiss, J. Bigger, L. Rolnitzky, 2016 .

Cardiac Arrhythmias during Anesthesia and Operation

J. Bigger, R. Katz, 1970, Anesthesiology.

Efficacy, safety, and tolerance of d-sotalol in patients with refractory supraventricular tachyarrhythmias.

J. Bigger, J. Reiffel, G. Kidwell, 1989, American heart journal.

Epicardial cardioverter-defibrillators do not cause postoperative arrhythmias. The CABG Patch Trial Investigators. Coronary Artery Bypass Graft.

J. Bigger, A. Curtis, J. Dimarco, 1998, The American journal of cardiology.

Risk Stratification with Low‐level Exercise Testing 2 Weeks After Acute Myocardial Infarction

J. Bigger, L. Rolnitzky, F. M. Weld, 1981, Circulation.

Sinus node echoes and concealed concealed conduction: additional sinus node phenomena confirmed in man by direct sinus node electrography.

J. Bigger, K. Ferrick, J. Reiffel, 1985, Journal of electrocardiology.

The ability of several short-term measures of RR variability to predict mortality after myocardial infarction.

J. Fleiss, J. Fleiss, J. Bigger, 1993, Circulation.

Frequency domain measures of heart period variability to assess risk late after myocardial infarction.

J. Fleiss, J. Bigger, L. Rolnitzky, 1993, Journal of the American College of Cardiology.

Effect of atenolol and diltiazem on heart period variability in normal persons.

J. Fleiss, J. Bigger, R. Kleiger, 1991, Journal of the American College of Cardiology.

Efficient estimation of the heart period power spectrum suitable for physiologic or pharmacologic studies.

J. Fleiss, J. Bigger, J. Rottman, 1990, The American journal of cardiology.

The electrophysiologic effects of low and high digoxin concentrations on isolated mammalian cardiac tissue: reversal by digoxin-specific antibody.

J. Bigger, W. Mandel, V. P. Butler, 1972, The Journal of clinical investigation.

Electrophysiological Effects of Diphenylhydantoin on Canine Purkinje Fibers

J. Bigger, B. Hoffman, A. Bassett, 1968, Circulation research.

Relationship Between the Plasma Level of Diphenylhydantoin Sodium and Its Cardiac Antiarrhythmic Effects

J. Bigger, D. Schmidt, H. Kutt, 1968, Circulation.

Prophylactic use of implanted cardiac defibrillators in patients at high risk for ventricular arrhythmias after coronary-artery bypass graft surgery. Coronary Artery Bypass Graft (CABG) Patch Trial Investigators.

J. Bigger, J T Bigger, 1997, The New England journal of medicine.

Progestational Activity of a New Acetoxyprogesterone Derivative (6 α-Methyl-6-Dehydro-17 α-Acetoxyprogesterone)

J. Bigger, R. Greenblatt, E. Jungck, 1963 .

Physical fitness as a determinant of vagal modulation.

J. Bigger, R. Steinman, R. Goldsmith, 1997, Medicine and science in sports and exercise.

The effect of quinidine and other oral antiarrhythmic drugs on serum digoxin. A prospective study.

J. Bigger, J. Reiffel, E. Giardina, 1980, Annals of internal medicine.

Interaction between quinidine and digoxin.

J. Bigger, J. Reiffel, E. Leahey, 1978, JAMA.

Ability of Holter electrocardiographic recording and atrial stimulation to detect sinus nodal dysfunction in symptomatic and asymptomatic patients with sinus bradycardia.

J. Bigger, D. Reid, J. Reiffel, 1977, The American journal of cardiology.

Cardiac Cellular Pharmacology: Automaticity in Cardiac Muscle—Its Alteration by Physical and Chemical Influences

J. Bigger, F. M. Weld, 1976 .

Tissue digoxin concentrations and digoxin effect during the quinidine-digoxin interaction.

J. Bigger, N. Warner, J. Barnard, 1985, Journal of the American College of Cardiology.

Metabolism of procainamide in rhesus monkey and man

J. Bigger, J. Bigger, A. Cohen, 1972, Clinical pharmacology and therapeutics.

Ventriculo‐atrial Conduction in Man

J. Bigger, B. N. Goldreyer, Bruce N. Goldreyer, 1970, Circulation.

Effect of lidocaine hydrochloride on membrane conductance in mammalian cardiac Purkinje fibers.

J. Bigger, M. Arnsdorf, 1972, The Journal of clinical investigation.

Effect of lidocaine on the electrophysiological properties of ventricular muscle and purkinje fibers.

J. Bigger, W. Mandel, J. T. Bicger, 1970, The Journal of clinical investigation.

Electrophysiologic Evaluation of Sinus Node Function in Patients with Sinus Node Dysfunction

J. Bigger, H. Strauss, A. Saroff, 1976, Circulation.

Effect of Lidocaine on the Early Inward Transient Current in Sheep Cardiac Purkinje Fibers

J. Bigger, F. M. Weld, 1975, Circulation research.

Electrophysiologic effects of lidocaine on isolated canine and rabbit atrial tissue.

J. Bigger, W. Mandel, 1971, The Journal of pharmacology and experimental therapeutics.

Effect of lidocaine on sinoatrial node and atrial fibers

J. Bigger, W. Mandel, 1970 .

DIPHENYLHYDANTOIN PLASMA LEVELS Table 1 Arrhythmias Studied : Results of Treatment of the Sixty-eight Patients in Group 1 * Arrhythmia Atrial fibrillation Atrial flutter Atrial premature systoles

By, J. Bigger, D. Schmidt, 2005 .

Actions of Diphenylhydantoin on the Electrical Properties of Isolated Rabbit and Canine Atria

J. Bigger, H. Strauss, B. Hoffman, 1968, Circulation research.

Antiarrhythmic treatment: an overview.

J. Bigger, 1984, The American journal of cardiology.

Effects of diphenylhydantoin on cardiac conduction and repolarization

J. Bigger, P. D. Harris, D. Weinberg, 1967 .

Predicting arrhythmic events after acute myocardial infarction using the signal-averaged electrocardiogram.

J. Fleiss, J. Bigger, R. Sciacca, 1992, The American journal of cardiology.

Site of reentry in paroxysmal supraventricular tachycardia in man.

J. Bigger, B. N. Goldreyer, Bruce N. Goldreyer, 1971, Circulation.

The Relationship Between Sinoatrial Conduction Time and Sinus Cycle Length Revisited

J. Bigger, J. Reiffel, 1987 .

Indirectly estimated sinoatrial conduction time by the atrial premature stimulus technique: patterns of error and the degree of associated inaccuracy as assessed by direct sinus node electrography.

J. Bigger, E. Gang, J. Reiffel, 1983, American heart journal.

Clinical and electrophysiologic characteristics of sinoatrial entrance block evaluated by direct sinus node electrography: prevalence, relation to antegrade sinoatrial conduction time, and relevance to sinus node disease.

J. Bigger, E. Gang, J. Reiffel, 1981, American heart journal.

The Human Sinus Node Electrogram: A Transvenous Catheter Technique and a Comparison of Directly Measured and Indirectly Estimated Sinoatrial Conduction Time in Adults

J. Bigger, E. Gang, J. Reiffel, 1980, Circulation.

Characteristics of extracellular potentials recorded from the sinoatrial pacemaker of the rabbit.

J. Bigger, B. Hoffman, M. Cramer, 1977, Circulation research.

Sinus node dysfunction caused by methyldopa and digoxin.

J. Bigger, J. Reiffel, J. Davis, 1981, JAMA.

SUPRAVENTRICULAR TACHYCARDIA Table 2 ECG Characteristics During Sinus Rhythm and SVT

J. Bigger, B. N. Goldreyer, 2005 .

"Paradoxical" prolongation of sinus nodal recovery time after atropine in the sick sinus syndrome.

J. Bigger, J. Reiffel, E. Giardina, 1975, The American journal of cardiology.

Pharmacologic and clinical control of antiarrhythmic drugs.

J. Bigger, 1975, The American journal of medicine.

and Rabbit Cardiac Tissue

J. Bigger, H. Strauss, B. Hoffman, 1970 .

R-R variability detects increases in vagal modulation with phenylephrine infusion.

J Thomas Bigger, Richard C Steinman, J. Bigger, 1998, American journal of physiology. Heart and circulatory physiology.

Stability over time of variables measuring heart rate variability in normal subjects

Richard C. Steinman, Joseph L. Fleiss, J. Thomas Bigger, 1991 .

Bretylium tosylate: a newly available antiarrhythmic drug for ventricular arrhythmias.

J. Bigger, R. H. Heissenbuttel, 1979, Annals of internal medicine.

The relationships among ventricular arrhythmias, left ventricular dysfunction, and mortality in the 2 years after myocardial infarction.

J P Miller, J. Fleiss, J. Miller, 1984, Circulation.

Effect of long-term digoxin therapy on autonomic function in patients with chronic heart failure.

J. Bigger, H. Krum, M. Packer, 1995, Journal of the American College of Cardiology.

Prevalence, characteristics and significance of ventricular tachycardia detected by 24-hour continuous electrocardiographic recordings in the late hospital phase of acute myocardial infarction.

J. Fleiss, J. Bigger, L. Rolnitzky, 1986, American Journal of Cardiology.

Prevalence and significance of ventricular tachycardia in the late hospital phase of myocardial infarction

J. Bigger, L. Rolnitzky, F. M. Weld, 1981 .

Risk stratification after acute myocardial infarction.

J. Bigger, J. Bigger, T. Wenger, 1978, The American journal of cardiology.

An Unusual Effect of Atropine on Overdrive Suppression

J. Bigger, H. Strauss, 1973 .

The effect of lidocaine on components of excitability in long mammalian cardiac Purkinje fibers.

J. Bigger, M. Arnsdorf, 1975, The Journal of pharmacology and experimental therapeutics.

Clinical types of proarrhythmic response to antiarrhythmic drugs.

J. Bigger, D. I. Sahar, J. Bigger, 1987, The American journal of cardiology.

Electrophysiologic studies of the sinus node and atria.

J. Bigger, K. Ferrick, J. Reiffel, 1985, Cardiovascular clinics.

Sinus node recovery times following the spontaneous termination of supraventricular tachycardia and following atrial overdrive pacing: a comparison.

J. Bigger, E. Gang, J. Reiffel, 1983, American heart journal.

Electrophysiological Effects of Imipramine on Ovine Cardiac Purkinje and Ventricular Muscle Fibers

J. Bigger, F. M. Weld, 1980, Circulation research.

Myocardial Monovalent Cation Transport during the Quinidine‐Digoxin Interaction in Dogs

J. Bigger, T. Hougen, T. Smith, 1984, Circulation research.

Quinidine and digoxin. An important interaction.

J. Bigger, E. Leahey, 1982, Drugs.

Quinidine-digoxin interaction: time course and pharmacokinetics.

J. Bigger, J. Rottman, J. Reiffel, 1981, The American journal of cardiology.

Events in the Cardiac Arrhythmia Suppression Trial (CAST): mortality in the entire population enrolled.

J. Bigger, D. Wyse, R. Reynolds-Haertle, 1991, Journal of the American College of Cardiology.

Patency of infarct-related artery. Effect of restoration of anterograde flow on vagal reflexes. ATRAMI (Automatic Tone and Reflexes After Myocardial Infarction) Investigators.

S. Hohnloser, J. Camm, J. Bigger, 1996, Circulation.

The mortality risk associated with digitalis treatment after myocardial infarction

T. Therneau, J. Fleiss, J. Bigger, 1987, Cardiovascular Drugs and Therapy.

Ventricular arrhythmias in ischemic heart disease: mechanism, prevalence, significance, and management.

J. Bigger, F. M. Weld, A. L. Wit, 1977, Progress in cardiovascular diseases.

Postinfarct risk stratification.

J. Bigger, A. Moss, J. Bigger, 1987, Progress in cardiovascular diseases.

CORONARY ARTERY DISEASE The relationships among ventricular arrhythmias , left ventricular dysfunction , and mortality in the 2 years after myocardial infarction *

J. Fleiss, J. Miller, J. Bigger, 2005 .

The Relationship Between the Metabolism of Procainamide and Sulfamethazine

J. Bigger, R. Stein, 1977, Circulation.

Cardiac Autonomic Control and Treatment of Hostility: A Randomized Controlled Trial

J. Bigger, E. Gorenstein, R. Steinman, 2010, Psychosomatic medicine.

Cardiac autonomic control and hostility in healthy subjects.

P A Shapiro, J M Gorman, J. Gorman, 1994, The American journal of cardiology.

The early termination of clinical trials: causes, consequences, and control. With special reference to trials in the field of arrhythmias and sudden death. Task Force of the Working Group on Arrhythmias of the European Society of Cardiology.

Ralph Lazzara, Peter J. Schwartz, Curt D. Furberg, 1994, Circulation.

Response to programmed ventricular stimulation: sensitivity, specificity and relation to heart disease.

J. Bigger, E. Gang, L. Rolnitzky, 1982, The American journal of cardiology.

Prevalence, characteristics and significance of ventricular tachycardia (three or more complexes) detected with ambulatory electrocardiographic recording in the late hospital phase of acute myocardial infarction.

J. Bigger, L. Rolnitzky, F. M. Weld, 1981, The American journal of cardiology.

Depression and coronary heart disease: recommendations for screening, referral, and treatment: a science advisory from the American Heart Association Prevention Committee of the Council on Cardiovascular Nursing, Council on Clinical Cardiology, Council on Epidemiology and Prevention, and Interdiscip

J Thomas Bigger, Daniel B Mark, D. Mark, 2008, Circulation.

Comparison between invasive and non-invasive measurements of baroreflex sensitivity; implications for studies on risk stratification after a myocardial infarction.

J. Bigger, P. Schwartz, R. Maestri, 2000, European heart journal.

Microvolt T-wave alternans and the risk of death or sustained ventricular arrhythmias in patients with left ventricular dysfunction.

J Thomas Bigger, Richard C Steinman, Anne B Curtis, 2006, Journal of the American College of Cardiology.

Microvolt T-Wave Alternans Distinguishes Between Patients Likely and Patients Not Likely to Benefit From Implanted Cardiac Defibrillator Therapy: A Solution to the Multicenter Automatic Defibrillator Implantation Trial (MADIT) II Conundrum

J Thomas Bigger, Richard C Steinman, E. Kaufman, 2004, Circulation.

Management of cardiac problems in the intensive care unit.

J. Bigger, R. H. Heissenbuttel, W. Lovejoy, 1971, The Medical clinics of North America.

Effect of digitalis treatment on survival after acute myocardial infarction.

J. Fleiss, J. Bigger, J. Bigger, 1985, The American journal of cardiology.

Risk Stratification in Post-MI Patients Based on Left Ventricular Ejection Fraction and Heart-Rate Turbulence

M. Malik, J. Bigger, G. Schmidt, 2003 .

A Statistical Model for Risk Stratification on the Basis of Left Ventricular Ejection Fraction and Heart-Rate Turbulence

J. Bigger, G. Schmidt, A. Schömig, 2000 .

Evaluation of Antiarrhythmic Drug Efficacy in Patients with an ICD:

G. Breithardt, R. Campbell, J. Bigger, 1999, Journal of cardiovascular electrophysiology.

A model of chronic ischemic arrhythmias: the relation between electrically inducible ventricular tachycardia, ventricular fibrillation threshold and myocardial infarct size.

J. Bigger, E. Gang, F. Livelli, 1982, The American journal of cardiology.

Mechanism of death and prevalence of myocardial ischemic symptoms in the terminal event after acute myocardial infarction.

J. Fleiss, L. Kuller, J. Bigger, 1988, The American journal of cardiology.

Changes in sample size and length of follow-up to maintain power in the coronary artery bypass graft (CABG) patch trial.

J. Bigger, L. Rolnitzky, D. Egan, 1998, Controlled clinical trials.

Effect of implantable cardioverter-defibrillator implantation on surgical morbidity in the CABG Patch Trial. Surgical Investigators of the Coronary Artery Bypass Graft Patch Trial.

J. Bigger, J. Hammon, H. Spotnitz, 1998, Circulation.

Proarrhythmia, arrhythmogenesis or aggravation of arrhythmia--a status report, 1987.

L. Horowitz, J. Bigger, M. Rosen, 1987, The American journal of cardiology.

Use of massive doses of procaineamide in the treatment of ventricular tachycardia in infancy.

J. Bigger, H. Gelband, C. Steeg, 1971, Pediatrics.

Definition of benign versus malignant ventricular arrhythmias: targets for treatment.

J. Bigger, 1983, The American journal of cardiology.

Centralized, stepped, patient preference-based treatment for patients with post-acute coronary syndrome depression: CODIACS vanguard randomized controlled trial.

Faith Parsons, Viola Vaccarino, Karina W Davidson, 2013, JAMA internal medicine.

Design and baseline data from the vanguard of the Comparison of Depression Interventions after Acute Coronary Syndrome (CODIACS) randomized controlled trial.

R. Carney, K. Freedland, A. Jaffe, 2012, Contemporary clinical trials.

Assessment and treatment of depression in patients with cardiovascular disease: National heart, lung, and blood institute working group report

Ellen Frank, K. Ranga R. Krishnan, David J. Kupfer, 2006, Annals of behavioral medicine : a publication of the Society of Behavioral Medicine.

Quinidine and Digoxin

J. Bigger, E. Leahey, Dr J. Thomas Bigger, 1982, Drugs.

Tissue digoxin concentrations during the quinidine-digoxin interaction.

J. Bigger, T. Hougen, T. Smith, 1983, The American journal of cardiology.

Time course of recovery of heart period variability after myocardial infarction.

J. Fleiss, J. Bigger, L. Rolnitzky, 1991, Journal of the American College of Cardiology.

Comparison of time- and frequency domain-based measures of cardiac parasympathetic activity in Holter recordings after myocardial infarction.

R J Cohen, J. Fleiss, J. Bigger, 1989, The American journal of cardiology.

Reliability of Office, Home, and Ambulatory Blood Pressure Measurements and Correlation With Left Ventricular Mass.

J. Schwartz, J. Bigger, T. Pickering, 2020, Journal of the American College of Cardiology.

icrovolt T-Wave Alternans and the Risk of eath or Sustained Ventricular Arrhythmias n Patients With Left Ventricular Dysfunction

J. Bigger, A. Curtis, J. Davidenko, 2005 .

Diabetes and outcomes of coronary artery bypass graft surgery in patients with severe left ventricular dysfunction: results from The CABG Patch Trial database. The CABG Patch Trial Investigators and Coordinators.

J. Bigger, W. Whang, Bigger Jt, 2000, Journal of the American College of Cardiology.

Automatic implantable cardioverter defibrillator implantation for malignant ventricular arrhythmias associated with congenital heart disease.

J. Bigger, H. Spotnitz, J. Steinberg, 1989, The American journal of cardiology.

Which postinfarction ventricular arrhythmias should be treated?

J. Bigger, L. Rolnitzky, F. M. Weld, 1982, American heart journal.

Temporal stability of heart period variability during a resting baseline and in response to psychological challenge.

J. Gorman, J. Bigger, R. Sloan, 1995, Psychophysiology.

Treatment of ventricular arrhythmias by United States cardiologists: a survey before the Cardiac Arrhythmia Suppression Trial results were available.

J. Bigger, J. Anderson, J. Morganroth, 1990, The American journal of cardiology.

Identification of patients at high risk for sudden cardiac death.

J. Bigger, 1984, The American journal of cardiology.

Mechanisms of death in the CABG Patch trial: a randomized trial of implantable cardiac defibrillator prophylaxis in patients at high risk of death after coronary artery bypass graft surgery.

J. Bigger, R. Kleiger, J. Rottman, 1999, Circulation.

Cardiac denervation and cardiovascular reactivity to psychological stress.

J. Gorman, J. Bigger, R. Sloan, 1994, The American journal of psychiatry.

Microvolt T-wave alternans: an effective approach to risk stratification in ischemic cardiomyopathy?

J. Bigger, D. Bloomfield, 2007, Nature Clinical Practice Cardiovascular Medicine.

Enhanced cardiac effect of digoxin during quinidine treatment.

J. Bigger, J. Reiffel, E. Leahey, 1979, Archives of internal medicine.

Predicting mortality after myocardial infarction from the response of RR variability to antiarrhythmic drug therapy.

J. Fleiss, J. Bigger, L. Rolnitzky, 1994, Journal of the American College of Cardiology.

Comparison of spontaneous vs. metronome-guided breathing on assessment of vagal modulation using RR variability.

J. Bigger, R. Steinman, M. Parides, 2001, American journal of physiology. Heart and circulatory physiology.

Biobehavioral factors in Cardiac Arrhythmia Pilot Study (CAPS). Review and examination.

J. Bigger, R. Sloan, 1991, Circulation.

Paroxysmal Supraventricular Tachycardia The authors reply

J. Bigger, B. N. Goldreyer, 1971 .

Electrophysiologic effects of procainamide on sinus function in patients with and without sinus node disease.

J. Bigger, E. Gang, J. Reiffel, 1982, American heart journal.

Electrocardiographic predictors in the ESVEM trial: unsustained ventricular tachycardia, heart period variability, and the signal-averaged electrocardiogram.

J. Bigger, R. Freedman, J T Bigger, 1996, Progress in cardiovascular diseases.

The effects of thioridazine on electrical and ischemic ventricular fibrillation in the dog heart in situ.

J. Bigger, J. Davis, 1981, The Journal of pharmacology and experimental therapeutics.

Effects of timolol and propranolol on inducible sustained ventricular tachyarrhythmias in dogs with subacute myocardial infarction.

J. Bigger, E. Gang, E. Uhl, 1984, The American journal of cardiology.

The correlation between heart period variability and mean period length.

J. Fleiss, J. Bigger, L. Rolnitzky, 1992, Statistics in medicine.

Ambulatory Electrocardiogram‐Based Tracking of T Wave Alternans in Postmyocardial Infarction Patients to Assess Risk of Cardiac Arrest or Arrhythmic Death

J. Bigger, P. Schwartz, M. Mittleman, 2003, Journal of cardiovascular electrophysiology.

Relative predictive value of T wave alternans and left ventricular ejection fraction for death and sustained ventricular arrhythmias in patients with left ventricular dysfunction

J. Bigger, R. Steinman, M. Parides, 2005 .

Assessment and treatment of depression in patients with cardiovascular disease: National heart, lung, and blood institute working group report

Ellen Frank, Ronald C Kessler, Karina W Davidson, 2006, Psychosomatic medicine.

Current approaches to drug treatment of ventricular arrhythmias.

J. Bigger, 1987, The American journal of cardiology.

Holter versus electrophysiologic studies in the management of malignant ventricular arrhythmias.

J. Bigger, J. Reiffel, 1983, The American journal of cardiology.

How should Ventricular Arrhythmias be Classified and which Patients should be Treated

J. Bigger, L. Rolnitzky, J. Coromilas, 1983 .

Is catch-22 alive and well and living at NHLBI? Reactions to 'digitalis--a new controversy regarding an old drug'.

J. Fleiss, J. Bigger, L. Rolnitzky, 1986, Circulation.

Risk stratification after myocardial infarction.

J. Bigger, 1985, Zeitschrift fur Kardiologie.

Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction

J. Bigger, P. Schwartz, J. Bigger, 1998, The Lancet.

Heart rate reactivity and heart period variability throughout the first year after heart transplantation.

J. Gorman, J. Bigger, R. Sloan, 1996, Psychophysiology.

Effect of diltiazem on cardiac rate and rhythm after myocardial infarction. Multicenter Diltiazem Postinfarction Trial Investigators.

J. Fleiss, J. Bigger, R. Kleiger, 1990, The American journal of cardiology.

Comparison of 24-hour parasympathetic activity in endurance-trained and untrained young men.

J. Fleiss, J. Bigger, J. Bigger, 1992, Journal of the American College of Cardiology.

Heart rate turbulence-based predictors of fatal and nonfatal cardiac arrest (The Autonomic Tone and Reflexes After Myocardial Infarction substudy).

Marek Malik, Georg Schmidt, Maria Teresa La Rovere, 2002, The American journal of cardiology.

Autonomic nervous system activity during myocardial ischemia in man estimated by power spectral analysis of heart period variability. The Multicenter Study of Silent Myocardial Ischemia Investigators.

J. Fleiss, J. Bigger, L. Rolnitzky, 1990, The American journal of cardiology.

Heart-rate turbulence after ventricular premature beats as a predictor of mortality after acute myocardial infarction

A. Camm, M. Malik, J. Bigger, 1999, The Lancet.

Effects of digoxin and enalapril on heart period variability and response to head-up tilt in normal subjects.

J. Fleiss, E. Kaufman, P. Stein, 1993, American Journal of Cardiology.

"Indeterminate" microvolt T-wave alternans tests predict high risk of death or sustained ventricular arrhythmias in patients with left ventricular dysfunction.

Richard J Cohen, Richard C Steinman, E. Kaufman, 2006, Journal of the American College of Cardiology.

Comparison of baroreflex sensitivity and heart period variability after myocardial infarction.

J. Fleiss, J. Bigger, L. Rolnitzky, 1989, Journal of the American College of Cardiology.

Antiarrhythmic effect of imipramine hydrochloride in patients with ventricular premature complexes without psychological depression.

J. Bigger, J. Bigger, E. Giardina, 1982, The American journal of cardiology.

Sick sinus syndrome.

J. Bigger, J. Reiffel, 1979, Annual review of medicine.

Comparison of the prognostic value of RR-interval variability after acute myocardial infarction in patients with versus those without diabetes mellitus.

J. Bigger, J. Bigger, W. Whang, 2003, The American journal of cardiology.

Vagal modulation of RR intervals during head-up tilt and the infusion of isoproterenol.

J. Fleiss, J. Bigger, L. Rolnitzky, 1995, The American journal of cardiology.

Site of Reentry in Paroxysmal Supraventricular Tachycardia in Man

J. Bigger, B. N. Goldreyer, 1971 .

ELECTROPHYSIOLOGY OF THE PERINODAL FIBERS 491 a junctional zone before reaching the crista terminaUs

J. Bigger, H. Strauss, 2005 .

A real-time screening alert improves patient recruitment efficiency.

Chunhua Weng, Adam B Wilcox, Karina W Davidson, 2011, AMIA ... Annual Symposium proceedings. AMIA Symposium.

Procaineamide in treatment of ventricular tachycardia.

J. Bigger, H. Gelband, C. Steeg, 1972, Pediatrics.

The Relationship Between the Metabolism of Procainamide and Sulfamethazine

J. Bigger, R. Stein, E. Giardina, 1977, Circulation.

METABOLISM OF PROCAINAMIDE / Giardina , Stein , Bigger collected

J. Bigger, R. Stein, E. Giardina, 2005 .

D. Mark, J. Bigger, P. Kaufmann, 2008, Circulation.

Effects of age on outcome of tilt-table testing.

J. Bigger, J. Bigger, M. Maurer, 1999, The American journal of cardiology.

A previously unrecognized drug interaction between quinidine and digoxin

J. Bigger, J. Reiffel, E. Leahey, 1979, Clinical cardiology.

Effect of Long-Term Digoxin Therapy ou Autonomic Function in Patients With Chronic Heart Failure

J. Bigger, H. Krum, M. Packer, 2016 .

Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) Investigators.

J. Bigger, M. L. La Rovere, F. I. Marcus, 1998, Lancet.