D. Giedroc

发表

Simulating RNA folding kinetics on approximated energy landscapes.

Shawna L. Thomas, N. Amato, Xinyu Tang, 2008, Journal of molecular biology.

Metalloregulatory proteins: metal selectivity and allosteric switching.

D. Giedroc, H. Reyes-caballero, G. Campanello, 2011, Biophysical chemistry.

Structure, stability and function of RNA pseudoknots involved in stimulating ribosomal frameshifting1

D. Giedroc, C. A. Theimer, P. L. Nixon, 2000, Journal of Molecular Biology.

Zinc site redesign in T4 gene 32 protein: structure and stability of cobalt(II) complexes formed by wild-type and metal ligand substitution mutants.

D. Giedroc, J. Guo, J. Guo, 1997, Biochemistry.

The zinc metalloregulatory protein Synechococcus PCC7942 SmtB binds a single zinc ion per monomer with high affinity in a tetrahedral coordination geometry.

D. Giedroc, M. Vanzile, N. Cosper, 2000, Biochemistry.

The RNA Molecule CsrB Binds to the Global Regulatory Protein CsrA and Antagonizes Its Activity in Escherichia coli *

D. Giedroc, J. Preston, T. Romeo, 1997, The Journal of Biological Chemistry.

Frameshifting RNA pseudoknots: Structure and mechanism

D. Giedroc, P. Cornish, 2008, Virus Research.

Energetics of a strongly pH dependent RNA tertiary structure in a frameshifting pseudoknot.

D. Giedroc, P. L. Nixon, 2000, Journal of molecular biology.

The SmtB/ArsR family of metalloregulatory transcriptional repressors: Structural insights into prokaryotic metal resistance.

D. Giedroc, M. Pennella, L. Busenlehner, 2003, FEMS microbiology reviews.

Solution NMR refinement of a metal ion bound protein using metal ion inclusive restrained molecular dynamics methods

Dhruva K. Chakravorty, D. Giedroc, K. Merz, 2013, Journal of biomolecular NMR.

CsoR is a novel Mycobacterium tuberculosis copper-sensing transcriptional regulator.

Tong Liu, James C Sacchettini, Graham N George, 2007, Nature chemical biology.

Crystal structure of Clostridium difficile toxin A

D. Giedroc, M. A. Farrow, D. Lacy, 2016, Nature Microbiology.

Biological and Chemical Adaptation to Endogenous Hydrogen Peroxide Production in Streptococcus pneumoniae D39

Kristy L. Hentchel, D. Giedroc, M. Winkler, 2017, mSphere.

Rapid, Low-Cost Detection of Water Contaminants Using Regulated In Vitro Transcription

Jaeyoung K. Jung, Khalid K. Alam, Jeong Wook Lee, 2019, bioRxiv.

Energetics of zinc-mediated interactions in the allosteric pathways of metal sensor proteins.

Dhruva K. Chakravorty, D. Giedroc, K. Merz, 2013, Journal of the American Chemical Society.

Thermal denaturation of T4 gene 32 protein: effects of zinc removal and substitution.

D. Giedroc, K. Williams, J. Sturtevant, 1988, Biochemistry.

Functional Determinants of Metal Ion Transport and Selectivity in Paralogous Cation Diffusion Facilitator Transporters CzcD and MntE in Streptococcus pneumoniae

D. Giedroc, Julia E. Martin, 2016, Journal of bacteriology.

Metallochaperones and metalloregulation in bacteria.

D. Giedroc, Katherine A. Edmonds, D. Capdevila, 2017, Essays in biochemistry.

A Q63E Rhodobacter sphaeroides AppA BLUF domain mutant is locked in a pseudo-light-excited signaling state.

D. Giedroc, C. Bauer, A. I. Arunkumar, 2010, Biochemistry.

A U-turn motif-containing stem-loop in the coronavirus 5' untranslated region plays a functional role in replication.

D. Giedroc, J. Leibowitz, Hyojeung Kang, 2007, RNA.

COG0523 proteins: A functionally diverse family of transition metal-regulated G3E P-loop GTP hydrolases from bacteria to man.

D. Giedroc, Katherine A. Edmonds, M. Jordan, 2021, Metallomics : integrated biometal science.

Bacterial Strategies to Maintain Zinc Metallostasis at the Host-Pathogen Interface*

D. Giedroc, Jiefei Wang, D. Capdevila, 2016, The Journal of Biological Chemistry.

Crystal structure of the zinc-dependent MarR family transcriptional regulator AdcR in the Zn(II)-bound state.

D. Giedroc, C. Dann, Alfredo J. Guerra, 2011, Journal of the American Chemical Society.

Structural and functional characterization of Mycobacterium tuberculosis CmtR, a PbII/CdII-sensing SmtB/ArsR metalloregulatory repressor.

D. Giedroc, L. Hemmingsen, Yun Wang, 2005, Biochemistry.

Crystal structure of Clostridium difficile toxin A.

D. Giedroc, M. A. Farrow, D. Lacy, 2016, Nature microbiology.

Metal‐Regulated Gene Expression

D. Giedroc, Alfredo J. Guerra, 2013 .

Insights into Protein Allostery in the CsoR/RcnR Family of Transcriptional Repressors.

Khadine A. Higgins, D. Giedroc, 2014, Chemistry letters.

MRE-Binding transcription factor-1: weak zinc-binding finger domains 5 and 6 modulate the structure, affinity, and specificity of the metal-response element complex.

D. Giedroc, X. Chen, Xiaohua Chen, 1999, Biochemistry.

Manganese acquisition and homeostasis at the host-pathogen interface

D. Giedroc, John P. Lisher, 2013, Front. Cell. Infect. Microbiol..

Discovery and structure of a widespread bacterial ABC transporter specific for ergothioneine

D. Giedroc, Katherine A. Edmonds, G. Gonzalez-Gutierrez, 2022, bioRxiv.

Clostridioides difficile Senses and Hijacks Host Heme for Incorporation into an Oxidative Stress Defense System.

Eric P. Skaar, D. Giedroc, V. de Crécy-Lagard, 2020, Cell host & microbe.

The Pneumococcal Iron Uptake Protein a (PiuA) Specifically Recognizes Tetradentate FeIIIbis- and Mono-Catechol Complexes.

D. Giedroc, Hongwei Wu, Elizabeth M. Nolan, 2020, Journal of molecular biology.

Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis

Eric P. Skaar, Jeffrey M. Spraggins, R. Caprioli, 2022, Cell.

Structure of Thermotoga maritima TM0439: implications for the mechanism of bacterial GntR transcription regulators with Zn2+-binding FCD domains.

I. Wilson, D. Giedroc, L. Hung, 2009, Acta crystallographica. Section D, Biological crystallography.

Structure of the Large Extracellular Loop of FtsX and Its Interaction with the Essential Peptidoglycan Hydrolase PcsB in Streptococcus pneumoniae

D. Giedroc, Hongwei Wu, M. Winkler, 2018, mBio.

Multi-metal Restriction by Calprotectin Impacts De Novo Flavin Biosynthesis in Acinetobacter baumannii.

Eric P. Skaar, D. Giedroc, W. Chazin, 2019, Cell chemical biology.

Conversion of S-phenylsulfonylcysteine residues to mixed disulfides at pH 4.0: utility in protein thiol blocking and in protein-S-nitrosothiol detection.

Benjamin D. Reeves, D. Singel, D. Giedroc, 2014, Organic & biomolecular chemistry.

Staphylococcus aureus CstB Is a Novel Multidomain Persulfide Dioxygenase-Sulfurtransferase Involved in Hydrogen Sulfide Detoxification.

Khadine A. Higgins, D. Giedroc, R. Armstrong, 2015, Biochemistry.

Zinc: DNA‐Binding Proteins

D. Giedroc, M. Pennella, 2006 .

Chen pseudoknots helix tertiary structural contacts in RNA − Predicting loop Material Supplemental

D. Giedroc, Song Cao, Shi-jie, 2010 .

Zn(II) coordination domain mutants of T4 gene 32 protein.

D. Giedroc, G. King, H. W. Giu, 1992, Biochemistry.

Mammalian copper biology: hitting the pause button in celebration of three pioneers and four decades of discovery.

D. Giedroc, R. Burke, S. La Fontaine, 2016, Metallomics : integrated biometal science.

Coordination chemistry of bacterial metal transport and sensing.

D. Giedroc, Faith E. Jacobsen, Zhenyu Ma, 2009, Chemical reviews.

Mutations in the N-terminal Cooperativity Domain of Gene 32 Protein Alter Properties of the T4 DNA Replication and Recombination Systems*

D. Giedroc, J. Villemain, Y. Ma, 2000, The Journal of Biological Chemistry.

Dual Functions of Single-stranded DNA-binding Protein in Helicase Loading at the Bacteriophage T4 DNA Replication Fork*

D. Giedroc, Tongsheng Wang, J. Villemain, 2004, Journal of Biological Chemistry.

Overexpression, purification, and characterization of recombinant T4 gene 32 protein22-301 (g32P-B).

D. Giedroc, K. Barnhart, R. Khan, 1990, The Journal of biological chemistry.

Site-specific 1,N6-ethenoadenylated single-stranded oligonucleotides as structural probes for the T4 gene 32 protein-ssDNA complex.

D. Giedroc, K. Barnhart, R. Khan, 1991, Biochemistry.

Interplay between manganese and zinc homeostasis in the human pathogen Streptococcus pneumoniae.

D. Giedroc, K. Kazmierczak, M. Winkler, 2011, Metallomics : integrated biometal science.

Gene 32 protein, the single-stranded DNA binding protein from bacteriophage T4, is a zinc metalloprotein.

D. Giedroc, K. Williams, W. Konigsberg, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Bacterial hydrophilins promote pathogen desiccation tolerance.

Eric P. Skaar, D. Giedroc, E. Skaar, 2022, Cell host & microbe.

Metabolic and Structural Insights into Hydrogen Sulfide Mis-Regulation in Enterococcus faecalis

D. Giedroc, J. Trinidad, Katherine A. Edmonds, 2022, Antioxidants.

A new player in bacterial sulfide‐inducible transcriptional regulation

D. Giedroc, 2017, Molecular microbiology.

SifR is an Rrf2-family quinone sensor associated with catechol iron uptake in Streptococcus pneumoniae D39

D. Giedroc, M. Winkler, Katherine A. Edmonds, 2022, The Journal of biological chemistry.

Mouse Hepatitis Virus Stem-Loop 4 Functions as a Spacer Element Required To Drive Subgenomic RNA Synthesis

D. Giedroc, J. Leibowitz, Pinghua Liu, 2011, Journal of Virology.

Recent developments in copper and zinc homeostasis in bacterial pathogens.

D. Giedroc, Joseph J Braymer, J. Braymer, 2014, Current opinion in chemical biology.

Coordination Chemistry of Bacterial Metal Transport and Sensing

D. Giedroc, Faith E. Jacobsen, Zhenyu Ma, 2010 .

Structural basis for persulfide-sensing specificity in a transcriptional regulator

D. Giedroc, D. Capdevila, G. Gonzalez-Gutierrez, 2020, Nature Chemical Biology.

The Response of Acinetobacter baumannii to Hydrogen Sulfide Reveals Two Independent Persulfide-Sensing Systems and a Connection to Biofilm Regulation

Eric P. Skaar, D. Giedroc, J. Trinidad, 2020, mBio.

Hydrogen Sulfide and Reactive Sulfur Species Impact Proteome S-Sulfhydration and Global Virulence Regulation in Staphylococcus aureus.

Eric P. Skaar, D. Giedroc, J. Trinidad, 2017, ACS infectious diseases.

Staphylococcus aureus sqr Encodes a Type II Sulfide:Quinone Oxidoreductase and Impacts Reactive Sulfur Speciation in Cells.

D. Giedroc, J. Trinidad, Hui Peng, 2016, Biochemistry.

Zinc metalloproteins involved in replication and transcription.

D. Giedroc, K. Williams, C. Martin, 1986, Journal of inorganic biochemistry.

Hydrogen peroxide sensing in Bacillus subtilis: it is all about the (metallo)regulator

D. Giedroc, 2009, Molecular microbiology.

Nucleic acid binding properties of recombinant Zn2 HIV-1 nucleocapsid protein are modulated by COOH-terminal processing.

D. Giedroc, R. Khan, 1994, The Journal of biological chemistry.

Calcium effects on calmodulin lysine reactivities.

D. Giedroc, K. Brew, D. Puett, 1987, Archives of biochemistry and biophysics.

Ratiometric pulsed alkylation/mass spectrometry of the cysteine pairs in individual zinc fingers of MRE-binding transcription factor-1 (MTF-1) as a probe of zinc chelate stability.

D. Giedroc, T. Baldwin, X. Chen, 2001, Biochemistry.

Mutational analysis of domain II beta of bacteriophage Mu transposase: domains II alpha and II beta belong to different catalytic complementation groups.

D. Giedroc, M. Jayaram, R. Harshey, 1998, Journal of Molecular Biology.

Elucidation of the functional metal binding profile of a Cd(II)/Pb(II) sensor CmtR(Sc) from Streptomyces coelicolor.

D. Giedroc, Yun Wang, J. Cavet, 2010, Biochemistry.

Mouse Hepatitis Virus Stem-Loop 4 Functions as a Spacer Element Required

D. Giedroc, J. Leibowitz, Pinghua Liu, 2011 .

Structural Lability in Stem–Loop 1 Drives a 5′ UTR–3′ UTR Interaction in Coronavirus Replication

D. Giedroc, J. Leibowitz, Hyojeung Kang, 2008, Journal of Molecular Biology.

Copper Transport and Trafficking at the Host–Bacterial Pathogen Interface

D. Giedroc, Yue Fu, F. Chang, 2014, Accounts of chemical research.

Solution NMR refinement of a metal ion bound protein using metal ion inclusive restrained molecular dynamics methods

Dhruva K. Chakravorty, D. Giedroc, K. Merz, 2013, Journal of biomolecular NMR.

Structural elements of metal selectivity in metal sensor proteins

D. Giedroc, M. Pennella, N. Cosper, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Effects of substitution of proposed Zn(II) ligand His81 or His64 in phage T4 gene 32 protein: spectroscopic evidence for a novel zinc coordination complex.

D. Giedroc, H. Qiu, 1994, Biochemistry.

Structural and functional differences between the two intrinsic zinc ions of Escherichia coli RNA polymerase.

D. Giedroc, J. Coleman, 1986, Biochemistry.

Mechanism-based inhibitors of dopamine beta-hydroxylase: inhibition by 2-bromo-3-(p-hydroxyphenyl)-1-propene.

D. Giedroc, J. Villafranca, G. Colombo, 1984, Biochemistry.

Kinetics of metal binding by the toxic metal-sensing transcriptional repressor Staphylococcus aureus pI258 CadC.

D. Giedroc, L. Busenlehner, 2006, Journal of inorganic biochemistry.

NMR spectroscopy of 113Cd(II)-substituted gene 32 protein.

D. Giedroc, B. A. Johnson, J. Coleman, 1989, Biochemistry.

Mechanistic Insights into the Metal-Dependent Activation of ZnII-Dependent Metallochaperones.

D. Giedroc, E. Skaar, A. Weiss, 2019, Inorganic chemistry.

Metal Ion Homeostasis

D. Giedroc, Jiefei Wang, D. Capdevila, 2019 .

A new structural paradigm in copper resistance in Streptococcus pneumoniae

Khadine A. Higgins, D. Giedroc, K. Kazmierczak, 2012, Nature chemical biology.

Energetics of allosteric negative coupling in the zinc sensor S. aureus CzrA.

D. Giedroc, Nicholas Grossoehme, 2009, Journal of the American Chemical Society.

Spectroscopic studies of the AppA BLUF domain from Rhodobacter sphaeroides: addressing movement of tryptophan 104 in the signaling state.

D. Giedroc, C. Bauer, A. I. Arunkumar, 2009, Biochemistry.

A Novel Cyanobacterial SmtB/ArsR Family Repressor Regulates the Expression of a CPx-ATPase and a Metallothionein in Response to Both Cu(I)/Ag(I) and Zn(II)/Cd(II)*

D. Giedroc, B. Ezaki, S. Nakashima, 2004, Journal of Biological Chemistry.

An Acinetobacter baumannii, Zinc-Regulated Peptidase Maintains Cell Wall Integrity during Immune-Mediated Nutrient Sequestration.

Eric P. Skaar, D. Giedroc, W. Chazin, 2019, Cell reports.

The CRR1 Nutritional Copper Sensor in Chlamydomonas Contains Two Distinct Metal-Responsive Domains[C][W][OA]

D. Giedroc, S. Merchant, J. Kropat, 2010, Plant Cell.

Alternate substrates of dopamine beta-hydroxylase. I. Kinetic investigations of benzyl cyanides as substrates and inhibitors.

D. Giedroc, J. Villafranca, G. Colombo, 1984, The Journal of biological chemistry.

Selenite and tellurite form mixed seleno- and tellurotrisulfides with CstR from Staphylococcus aureus.

D. Giedroc, R. Arnold, J. Luebke, 2013, Metallomics : integrated biometal science.

Metal-dependent allosteric activation and inhibition on the same molecular scaffold: the copper sensor CopY from Streptococcus pneumoniae

Khadine A. Higgins, Alexander D. Jacobs, D. Giedroc, 2017, Chemical science.

Molecular Evolution of Transition Metal Bioavailability at the Host-Pathogen Interface.

D. Giedroc, A. Vila, D. Capdevila, 2020, Trends in microbiology.

Structural determinants of persulfide-sensing specificity in a dithiol-based transcriptional regulator

D. Giedroc, D. Capdevila, G. Gonzalez-Gutierrez, 2020, bioRxiv.

Multi-metal nutrient restriction and crosstalk in metallostasis systems in microbial pathogens.

D. Giedroc, Jiefei Wang, D. Capdevila, 2020, Current opinion in microbiology.

Entropy redistribution controls allostery in a metalloregulatory protein

D. Giedroc, Hongwei Wu, D. Capdevila, 2017, Proceedings of the National Academy of Sciences.

The zinc efflux activator SczA protects Streptococcus pneumoniae serotype 2 D39 from intracellular zinc toxicity

D. Giedroc, M. Winkler, G. Campanello, 2017, Molecular microbiology.

The S2 Cu(i) site in CupA from Streptococcus pneumoniae is required for cellular copper resistance.

D. Giedroc, Hongwei Wu, Yue Fu, 2016, Metallomics : integrated biometal science.

Resolution of Stepwise Cooperativities of Copper Binding by the Homotetrameric Copper-Sensitive Operon Repressor (CsoR): Impact on Structure and Stability.

Jonathan M. Dilger, D. Giedroc, V. Wysocki, 2015, Angewandte Chemie.

The metalloregulatory zinc site in Streptococcus pneumoniae AdcR, a zinc-activated MarR family repressor.

D. Giedroc, K. Kazmierczak, M. Winkler, 2010, Journal of molecular biology.

Unnatural amino acid substitution as a probe of the allosteric coupling pathway in a mycobacterial Cu(I) sensor.

D. Giedroc, R. DiMarchi, G. George, 2009, Journal of the American Chemical Society.

Copper sensing function of Drosophila metal-responsive transcription factor-1 is mediated by a tetranuclear Cu(I) cluster

D. Giedroc, W. Schaffner, G. George, 2008, Nucleic acids research.

Metal sensor proteins: nature's metalloregulated allosteric switches.

D. Giedroc, A. I. Arunkumar, David P Giedroc, 2007, Dalton transactions.

Ratiometric pulsed alkylation mass spectrometry as a probe of thiolate reactivity in different metalloderivatives of Staphylococcus aureus pI258 CadC.

D. Giedroc, D. Russell, L. Busenlehner, 2004, Biochemistry.

Multiple metal binding domains enhance the Zn(II) selectivity of the divalent metal ion transporter AztA.

D. Giedroc, H. Reyes-caballero, R. A. Scott, 2007, Biochemistry.

Recombinant HIV-1 nucleocapsid protein accelerates HIV-1 reverse transcriptase catalyzed DNA strand transfer reactions and modulates RNase H activity.

S. Balasubramanian, D. Giedroc, S. Benkovic, 1994, Biochemistry.

Dissecting non-canonical interactions in frameshift-stimulating mRNA pseudoknots

M. Hennig, D. Giedroc, P. Cornish, 2006, Journal of biomolecular NMR.

Recombinant human immunodeficiency virus type 1 nucleocapsid (NCp7) protein unwinds tRNA.

D. Giedroc, R. Khan, 1992, The Journal of biological chemistry.

SHAPE analysis of the RNA secondary structure of the Mouse Hepatitis Virus 5’ untranslated region and N-terminal nsp1 coding sequences

D. Giedroc, Elyse V. Wudeck, J. Leibowitz, 2014, Virology.

Solution Structure of Mouse Hepatitis Virus (MHV) nsp3a and Determinants of the Interaction with MHV Nucleocapsid (N) Protein

D. Giedroc, S. Keane, 2013, Journal of Virology.

Coronavirus N Protein N-Terminal Domain (NTD) Specifically Binds the Transcriptional Regulatory Sequence (TRS) and Melts TRS-cTRS RNA Duplexes

D. Giedroc, C. Dann, J. Leibowitz, 2009, Journal of Molecular Biology.

des-(1–13) Human β-endorphin interacts with calmodulin

N. Ling, D. Giedroc, D. Puett, 1983, Peptides.

The global structures of a wild-type and poorly functional plant luteoviral mRNA pseudoknot are essentially identical.

D. Giedroc, P. Cornish, David P Giedroc, 2006, RNA.

Identification of beta-endorphin residues 14-25 as a region involved in the inhibition of calmodulin-stimulated phosphodiesterase activity.

N. Ling, D. Giedroc, D. Puett, 1983, Biochemistry.

Demonstration by covalent cross-linking of a specific interaction between beta-endorphin and calmodulin.

N. Ling, D. Giedroc, J. V. Staros, 1983, The Journal of biological chemistry.

Differential trace labeling of calmodulin: investigation of binding sites and conformational states by individual lysine reactivities. Effects of beta-endorphin, trifluoperazine, and ethylene glycol bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid.

D. Giedroc, K. Brew, D. Puett, 1985, The Journal of biological chemistry.

Functional properties of covalent beta-endorphin peptide/calmodulin complexes. Chlorpromazine binding and phosphodiesterase activation.

N. Ling, D. Giedroc, J. V. Staros, 1985, Biochemistry.

Ribosomal Frameshifting in Decoding Plant Viral RNAs

D. Giedroc, W. Miller, W. Miller, 2009, Recoding: Expansion of Decoding Rules Enriches Gene Expression.

Solution structure of a luteoviral P1-P2 frameshifting mRNA pseudoknot.

Alexander Rich, A. Rich, M. Hennig, 2002, Journal of molecular biology.

Equilibrium unfolding pathway of an H-type RNA pseudoknot which promotes programmed −1 ribosomal frameshifting1

D. Giedroc, C. A. Theimer, 1999, Journal of Molecular Biology.

Base-pairings within the RNA pseudoknot associated with the simian retrovirus-1 gag-pro frameshift site.

D. Giedroc, Z. Du, M. Hansen, 1997, Journal of molecular biology.

Perturbation of manganese metabolism disrupts cell division in Streptococcus pneumoniae

D. Giedroc, M. Winkler, John P. Lisher, 2017, Molecular microbiology.

The function of zinc in gene 32 protein from T4.

D. Giedroc, K. Williams, J. Coleman, 1987, Biochemistry.

Functional Role of Solvent Entropy and Conformational Entropy of Metal Binding in a Dynamically Driven Allosteric System.

D. Giedroc, Hongwei Wu, G. Campanello, 2018, Journal of the American Chemical Society.

Tuning site-specific dynamics to drive allosteric activation in a pneumococcal zinc uptake regulator

D. Giedroc, Hongwei Wu, D. Capdevila, 2018, bioRxiv.

A Novel Cysteine Cluster in Human Metal-responsive Transcription Factor 1 Is Required for Heavy Metal-induced Transcriptional Activation in Vivo*

Walter Schaffner, D. Giedroc, W. Schaffner, 2004, Journal of Biological Chemistry.

Control of Copper Resistance and Inorganic Sulfur Metabolism by Paralogous Regulators in Staphylococcus aureus*

Eric P. Skaar, D. Giedroc, R. A. Scott, 2011, The Journal of Biological Chemistry.

Iron Acquisition by Bacterial Pathogens: Beyond Tris‐Catecholate Complexes

D. Giedroc, Yifan Zhang, Sambuddha Sen, 2020, Chembiochem : a European journal of chemical biology.

Co‐ordinate synthesis and protein localization in a bacterial organelle by the action of a penicillin‐binding‐protein

D. Giedroc, Y. Brun, R. Arnold, 2013, Molecular microbiology.

A loop 2 cytidine-stem 1 minor groove interaction as a positive determinant for pseudoknot-stimulated -1 ribosomal frameshifting.

M. Hennig, D. Giedroc, P. Cornish, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Contribution of the intercalated adenosine at the helical junction to the stability of the gag-pro frameshifting pseudoknot from mouse mammary tumor virus.

D. Giedroc, C. A. Theimer, 2000, RNA.

Thermodynamics of stabilization of RNA pseudoknots by cobalt(III) hexaammine.

D. Giedroc, C. A. Theimer, P. L. Nixon, 1999, Biopolymers.

Equilibrium unfolding (folding) pathway of a model H-type pseudoknotted RNA: the role of magnesium ions in stability.

D. Giedroc, P. L. Nixon, 1998, Biochemistry.

Non-nearest neighbor effects on the thermodynamics of unfolding of a model mRNA pseudoknot.

D. Giedroc, C. A. Theimer, H. Krisch, 1998, Journal of molecular biology.

Structure of the autoregulatory pseudoknot within the gene 32 messenger RNA of bacteriophages T2 and T6: a model for a possible family of structurally related RNA pseudoknots.

D. Giedroc, Z. Du, D. Hoffman, 1996, Biochemistry.

Physical characterization of the manganese-sensing pneumococcal surface antigen repressor from Streptococcus pneumoniae.

Khadine A. Higgins, D. Giedroc, John P. Lisher, 2013, Biochemistry.

Putative cis-Acting Stem-Loops in the 5′ Untranslated Region of the Severe Acute Respiratory Syndrome Coronavirus Can Substitute for Their Mouse Hepatitis Virus Counterparts

D. Giedroc, M. E. Schroeder, J. Leibowitz, 2006, Journal of Virology.

Cell-free biosensors for rapid detection of water contaminants

Jaeyoung K. Jung, Khalid K. Alam, Jeong Wook Lee, 2020, Nature Biotechnology.

Allosteric inhibition of a zinc-sensing transcriptional repressor: insights into the arsenic repressor (ArsR) family.

D. Giedroc, Yuzhen Ye, C. Dann, 2013, Journal of molecular biology.

Metal site occupancy and allosteric switching in bacterial metal sensor proteins.

D. Giedroc, Alfredo J. Guerra, 2012, Archives of biochemistry and biophysics.

Illuminating allostery in metal sensing transcriptional regulators.

D. Giedroc, Nicholas Grossoehme, 2012, Methods in molecular biology.

Spectroscopic characterization of Co(II)-, Ni(II)-, and Cd(II)-substituted wild-type and non-native retroviral-type zinc finger peptides

D. Giedroc, X. Chen, M. Chu, 2000, JBIC Journal of Biological Inorganic Chemistry.

The Response of Acinetobacter baumannii to Zinc Starvation.

Eric P. Skaar, D. Giedroc, V. de Crécy-Lagard, 2016, Cell host & microbe.

Individual metal ligands play distinct functional roles in the zinc sensor Staphylococcus aureus CzrA.

D. Giedroc, M. Pennella, A. I. Arunkumar, 2006, Journal of molecular biology.

Allosteric negative regulation of smt O/P binding of the zinc sensor, SmtB, by metal ions: a coupled equilibrium analysis.

D. Giedroc, M. Vanzile, Xiaohua Chen, 2002, Biochemistry.

Hydrogen Sulfide Signaling and Enzymology

D. Giedroc, José A. Brito, Brenna J. C. Walsh, 2019 .

Sulfide Homeostasis and Nitroxyl Intersect via Formation of Reactive Sulfur Species in Staphylococcus aureus

Eric P. Skaar, D. Giedroc, T. Kehl-Fie, 2017, mSphere.

Cysteine sulfur chemistry in transcriptional regulators at the host-bacterial pathogen interface.

D. Giedroc, J. Luebke, 2015, Biochemistry.

Erratum: Single-stranded DNA-binding protein enhances the stability of CTG triplet repeats in Escherichia coli (Journal of Bacteriology 178:16 (5042))

R. Sinden, D. Giedroc, R. Wells, 1996 .

Solution structure and backbone dynamics of Mason‐Pfizer monkey virus (MPMV) nucleocapsid protein

D. Giedroc, K. Kaluarachchi, Yun Gao, 1998, Protein science : a publication of the Protein Society.

Cell-free biosensors for rapid detection of water contaminants

Jaeyoung K. Jung, Khalid K. Alam, D. Giedroc, 2020, Nature Biotechnology.

Retroviral nucleocapsid proteins possess potent nucleic acid strand renaturation activity

D. Giedroc, F. Dib-Hajj, Raza Khan, 1993, Protein science : a publication of the Protein Society.

strand renaturation activity Retroviral nucleocapsid proteins possess potent nucleic acid

D. Giedroc, F. Dib-Hajj, R. Khan, 2002 .

Spectroscopic properties of the metalloregulatory Cd(II) and Pb(II) sites of S. aureus pI258 CadC.

D. Giedroc, N. Cosper, R. A. Scott, 2001, Biochemistry.

H2S and reactive sulfur signaling at the host-bacterial pathogen interface

D. Giedroc, Brenna J. C. Walsh, 2020, The Journal of Biological Chemistry.

Increased intracellular persulfide levels attenuate HlyU-mediated hemolysin transcriptional activation in Vibrio cholerae

D. Giedroc, A. B. Dalia, D. Capdevila, 2023, bioRxiv.

Conformational Heterogeneity in the C-terminal Zinc Fingers of Human MTF-1

D. Giedroc, M. Pennella, A. LiWang, 2001, The Journal of Biological Chemistry.

Cu(I)-mediated Allosteric Switching in a Copper-sensing Operon Repressor (CsoR)*

Yun-Xing Wang, D. Giedroc, C. Dann, 2014, The Journal of Biological Chemistry.

Solution structure of a paradigm ArsR family zinc sensor in the DNA-bound state

D. Giedroc, G. Campanello, A. I. Arunkumar, 2009, Proceedings of the National Academy of Sciences.

The role of protein-protein interactions in the assembly of the presynaptic filament for T4 homologous recombination.

D. Giedroc, T. Kodadek, H. Jiang, 1993, The Journal of biological chemistry.

Hydrogen Sulfide Sensing through Reactive Sulfur Species (RSS) and Nitroxyl (HNO) in Enterococcus faecalis.

D. Giedroc, S. Hultgren, J. Trinidad, 2018, ACS chemical biology.

A Mn-sensing riboswitch activates expression of a Mn2+/Ca2+ ATPase transporter in Streptococcus

D. Giedroc, M. Winkler, Julia E. Martin, 2019, Nucleic acids research.

Conformational analysis and chemical reactivity of the multidomain sulfurtransferase, Staphylococcus aureus CstA.

Khadine A. Higgins, D. Giedroc, Hui Peng, 2015, Biochemistry.

Polysulfide metabolizing enzymes influence SqrR-mediated sulfide-induced transcription by impacting intracellular polysulfide dynamics

D. Giedroc, T. Masuda, Takayuki Shimizu, 2023, PNAS nexus.

Sulfide-responsive transcriptional repressor SqrR functions as a master regulator of sulfide-dependent photosynthesis

D. Giedroc, J. Trinidad, Takayuki Shimizu, 2017, Proceedings of the National Academy of Sciences.

Protocol for using organic persulfides to measure the chemical reactivity of persulfide sensors

D. Giedroc, D. Capdevila, Joseph N. Fakhoury, 2022, STAR protocols.

Functional asymmetry and chemical reactivity of CsoR family persulfide sensors

D. Giedroc, D. Capdevila, M. Bringas, 2021, bioRxiv.

Thioredoxin Profiling of Multiple Thioredoxin-Like Proteins in Staphylococcus aureus

D. Giedroc, J. Trinidad, Hui Peng, 2018, Front. Microbiol..

The CsoR‐like sulfurtransferase repressor (CstR) is a persulfide sensor in Staphylococcus aureus

Eric P. Skaar, D. Giedroc, T. Kehl-Fie, 2014, Molecular microbiology.

Simulations of allosteric motions in the zinc sensor CzrA.

Bing Wang, Kenneth M. Merz, Dhruva K. Chakravorty, 2012, Journal of the American Chemical Society.

A metal-ligand-mediated intersubunit allosteric switch in related SmtB/ArsR zinc sensor proteins.

James C Sacchettini, D. Giedroc, J. Sacchettini, 2003, Journal of molecular biology.

Metal retention and replacement in QueD2 protect queuosine-tRNA biosynthesis in metal-starved Acinetobacter baumannii

D. Giedroc, J. Trinidad, G. Gonzalez-Gutierrez, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Zinc-free and reduced T4 gene 32 protein binds single-stranded DNA weakly and fails to stimulate UvsX-catalyzed homologous pairing.

D. Giedroc, T. Kodadek, H. Qiu, 1994, The Journal of biological chemistry.

Electrostatic occlusion and quaternary structural ion pairing are key determinants of Cu(I)-mediated allostery in the copper-sensing operon repressor (CsoR).

D. Giedroc, Julia E. Martin, F. Chang, 2015, Biochemistry.

Functional Transcriptional Regulatory Sequence (TRS) RNA Binding and Helix Destabilizing Determinants of Murine Hepatitis Virus (MHV) Nucleocapsid (N) Protein*

D. Giedroc, J. Leibowitz, Pinghua Liu, 2012, The Journal of Biological Chemistry.

X-ray and Visible Absorption Spectroscopy of Wild-Type and Mutant T4 Gene 32 Proteins: His64, not His81, Is the Non-Thiolate Zinc Ligand

D. Giedroc, R. A. Scott, Jun Dong, 1995 .

Structural Characterization of Distinct α3N and α5 Metal Sites in the Cyanobacterial Zinc Sensor SmtB

D. Giedroc, M. Vanzile, Xiaohua Chen, 2002 .

Elucidation of Primary (α3N) and Vestigial (α5) Heavy Metal-binding Sites in Staphylococcus aureus pI258 CadC: Evolutionary Implications for Metal Ion Selectivity of ArsR/SmtB Metal Sensor Proteins

D. Giedroc, T. Weng, J. Penner‐Hahn, 2002 .

Metal response element (MRE)-binding transcription factor-1 (MTF-1): structure, function, and regulation.

D. Giedroc, X. Chen, J. Apuy, 2001, Antioxidants & redox signaling.

Staphylococcus aureus glucose-induced biofilm accessory protein A (GbaA) is a monothiol-dependent electrophile sensor.

Eric P. Skaar, D. Giedroc, Lauren D. Palmer, 2020, Biochemistry.

Metal Specificity of Metallosensors

Khadine A. Higgins, D. Giedroc, 2013 .

Molecular insights into the metal selectivity of the copper(I)-sensing repressor CsoR from Bacillus subtilis.

D. Giedroc, R. A. Scott, Zhenyu Ma, 2009, Biochemistry.

Thermodynamics of folding of the RNA pseudoknot of the T4 gene 32 autoregulatory messenger RNA.

D. Giedroc, K. Kaluarachchi, Z. Du, 1996, Biochemistry.

Pairwise coupling analysis of helical junction hydrogen bonding interactions in luteoviral RNA pseudoknots.

D. Giedroc, P. Cornish, 2006, Biochemistry.

Predicting loop-helix tertiary structural contacts in RNA pseudoknots.

Shi-Jie Chen, D. Giedroc, Song Cao, 2010, RNA.

A zinc(II)/lead(II)/cadmium(II)-inducible operon from the cyanobacterium anabaena is regulated by AztR, an α3N ArsR/SmtB metalloregulator

D. Giedroc, Tong‐Xian Liu, J. W. Golden, 2005 .

Solution structure of Mycobacterium tuberculosis NmtR in the apo state: insights into Ni(II)-mediated allostery.

Yuzhen Ye, Kenneth M Merz, Dhruva K. Chakravorty, 2012, Biochemistry.

A Nickel-Cobalt-sensing ArsR-SmtB Family Repressor

D. Giedroc, M. Pennella, N. Robinson, 2002, The Journal of Biological Chemistry.

Mycobacterium tuberculosis NmtR harbors a nickel sensing site with parallels to Escherichia coli RcnR.

D. Giedroc, H. Reyes-caballero, C. Lee, 2011, Biochemistry.

A Cu(I)-sensing ArsR family metal sensor protein with a relaxed metal selectivity profile.

Tong Liu, Lars Hemmingsen, D. Giedroc, 2008, Biochemistry.

Structural Determinants of Metal Selectivity in Prokaryotic Metal-responsive Transcriptional Regulators

David P. Giedroc, D. Giedroc, M. Pennella, 2005, Biometals.

Characterization of a metalloregulatory bismuth(III) site in Staphylococcusaureus pI258 CadC repressor

D. Giedroc, L. Busenlehner, J. Apuy, 2002, JBIC Journal of Biological Inorganic Chemistry.

1H, 13C, 15N resonance assignments of the extracellular loop 1 domain (ECL1) of Streptococcus pneumoniae D39 FtsX, an essential cell division protein

D. Giedroc, M. Winkler, Yue Fu, 2016, Biomolecular NMR assignments.

Methods and Technologies for Studying Metals in Biological Systems

Eric P. Skaar, D. Giedroc, C. Contag, 2015 .

Allosteric coupling between transition metal-binding sites in homooligomeric metal sensor proteins.

D. Giedroc, Nicholas Grossoehme, 2012, Methods in molecular biology.

Backbone resonance assignments of the homotetrameric (48 kD) copper sensor CsoR from Geobacillus thermodenitrificans in the apo- and Cu(I)-bound states: insights into copper-mediated allostery

D. Giedroc, H. Coyne, 2013, Biomolecular NMR assignments.

Ratiometric pulse-chase amidination mass spectrometry as a probe of biomolecular complex formation.

D. Giedroc, J. Reilly, M. Lauber, 2011, Analytical chemistry.

Structural and functional heterogeneity among the zinc fingers of human MRE-binding transcription factor-1.

D. Giedroc, Xiaohua Chen, and Anshu Agarwal, 1998, Biochemistry.

Interaction of retroviral nucleocapsid proteins with transfer RNAPhe: a lead ribozyme and 1H NMR study.

D. Giedroc, K. Kaluarachchi, R. Khan, 1996, Nucleic acids research.

Characterization of a Cooperativity Domain Mutant Lys3 → Ala (K3A) T4 Gene 32 Protein*

D. Giedroc, Jana L. Villemain, 1996, The Journal of Biological Chemistry.

Energetics of arginine-4 substitution mutants in the N-terminal cooperativity domain of T4 gene 32 protein.

D. Giedroc, J. Villemain, 1993, Biochemistry.

The N-terminal B-domain of T4 gene 32 protein modulates the lifetime of cooperatively bound Gp32-ss nucleic acid complexes.

D. Giedroc, J. Villemain, 1996, Biochemistry.

Physical characterization of the manganese-sensing pneumococcal surface antigen repressor from Streptococcus pneumoniae.

Khadine A. Higgins, D. Giedroc, John P. Lisher, 2013, Biochemistry.

Solution Structure of Mouse Hepatitis Virus (MHV) nsp3a and Determinants of the Interaction with MHV Nucleocapsid (N) Protein

D. Giedroc, S. Keane, 2013, Journal of Virology.

Sensing and regulation of reactive sulfur species (RSS) in bacteria.

D. Giedroc, D. Capdevila, Joseph N. Fakhoury, 2023, Current opinion in chemical biology.

The structure of plastocyanin tunes the midpoint potential by restricting axial ligation of the reduced copper ion

Claire C Mammoser, D. Giedroc, M. Thielges, 2023, Communications chemistry.

A conserved RNA pseudoknot in a putative molecular switch domain of the 3'-untranslated region of coronaviruses is only marginally stable.

D. Giedroc, Song Cao, Shi-jie Chen, 2011, RNA.

Unnatural amino acid substitution as a probe of the allosteric coupling pathway in a mycobacterial Cu(I) sensor.

D. Giedroc, R. DiMarchi, G. George, 2009, Journal of the American Chemical Society.

Solution NMR refinement of a metal ion bound protein using metal ion inclusive restrained molecular dynamics methods

Dhruva K. Chakravorty, D. Giedroc, K. Merz, 2013, Journal of Biomolecular NMR.

The solution structure of coronaviral stem‐loop 2 (SL2) reveals a canonical CUYG tetraloop fold

D. Giedroc, C. Lee, Lichun Li, 2011, FEBS Letters.

Detection of scalar couplings involving 2'-hydroxyl protons across hydrogen bonds in a frameshifting mRNA pseudoknot.

M. Hennig, D. Giedroc, P. Cornish, 2003, Journal of the American Chemical Society.

Mouse Hepatitis Virus Stem-Loop 2 Adopts a uYNMG(U)a-Like Tetraloop Structure That Is Highly Functionally Tolerant of Base Substitutions

D. Giedroc, J. Leibowitz, Lichun Li, 2009, Journal of Virology.

A Previously Unrecognized Unr Stem-Loop Structure in the Coronavirus 5’ Untranslated Region Plays a Functional role in Replication

D. Giedroc, J. Leibowitz, Lichun Li, 2006, Advances in experimental medicine and biology.

1H, 13C, 15N resonance assignments of the extracellular loop 1 domain (ECL1) of Streptococcus pneumoniae D39 FtsX, an essential cell division protein

D. Giedroc, M. Winkler, K. E. Bruce, 2015, Biomolecular NMR Assignments.

Recombinant human immunodeficiency virus type 1 nucleocapsid (NCp7) protein unwinds tRNA.

D. Giedroc, Raza Khan, 1992, The Journal of biological chemistry.

The five homologous CiaR-controlled Ccn sRNAs of Streptococcus pneumoniae modulate Zn-resistance

D. Giedroc, Dhriti Sinha, Nicholas R. De Lay, 2023, bioRxiv.