Christopher J. Schofield

发表

Japan-UK Science, Technology & Innovation Symposium 2014 in London Expanding the Protein and Peptide Universe

Christopher J. Schofield, Hiroaki Suga, 2014 .

Epimerization and desaturation by carbapenem synthase (CarC). A hybrid DFT study

Christopher J. Schofield, Tomasz Borowski, Per E. M. Siegbahn, 2006, J. Comput. Chem..

Novel multi-component approaches towards dimeric epidithiodiketopiperazines as anti-cancer agents

Christopher J. Schofield, Bc Sil, Kristina M. Cook, 2011 .

Figure 16, Probe development/medicinal chemistry optimization flowchart

Anton Simeonov, Ajit Jadhav, Akane Kawamura, 2013 .

Hypoxia-dependent sequestration of an oxygen sensor by a widespread structural motif can shape the hypoxic response - a predictive kinetic model

Christopher J. Schofield, Béla Novák, Bernhard Schmierer, 2010, BMC Systems Biology.

A promising cancer target: lead compounds blocking the HIF-1alpha/p300 interaction

Christopher J. Schofield, Kristina M. Cook, William D. Figg, 2008 .

Journal of Medicinal Chemistry

Christopher J. Schofield, Tom Brown, Paulette Charlier, 2010 .

DNA aptamers for as analytical tools for the quantitative analysis of DNA-dealkylating enzymes.

Christopher J. Schofield, Sergey N. Krylov, Eleanor A. L. Bagg, 2011, Analytical biochemistry.

Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes

Geoffrey J. Barton, Peter L. Roach, Christopher J. Schofield, 1995, Nature.

The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases

Weston B. Struwe, Simon Davis, Christopher J. Schofield, 2018, Nature Chemical Biology.

X-ray snapshots of serine protease catalysis reveal a tetrahedral intermediate

Karl Edman, Christopher J. Schofield, Thomas R. Schneider, 2001, Nature Structural Biology.

Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation

Hwanho Choi, Christopher J. Schofield, C. Schofield, 2014, Nucleic acids research.

Asparagine and Aspartate Hydroxylation of the Cytoskeletal Ankyrin Family Is Catalyzed by Factor-inhibiting Hypoxia-inducible Factor

Christopher J. Schofield, Wei Ge, Timothy D. W. Claridge, 2010, The Journal of Biological Chemistry.

Hydroxamate Inhibitors ofAeromonas hydrophilaAE036 Metallo-B-lactamase

Christopher J. Schofield, Magnus W. Walter, Gianfranco Amicosante, 1999 .

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

James E. Bray, Christopher J. Schofield, Tomasz Borowski, 2007, Nature.

Inhibition of 2‐Oxoglutarate Dependent Oxygenases

Akane Kawamura, Christopher J. Schofield, Nathan R. Rose, 2011 .

An approach to enzyme inhibition employing reversible boronate ester formation

Christopher J. Schofield, Tom Brown, Timothy D. W. Claridge, 2011 .

Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models

Giovanni Coppola, Christopher J. Schofield, Sama F. Sleiman, 2016, Science Translational Medicine.

Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL

Christopher J. Schofield, David I. Stuart, Timothy D. W. Claridge, 2002, Nature.

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

Christopher J. Schofield, Cesar Ramirez-Molina, Udo Oppermann, 2012, Nature.

Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase

Christopher J. Schofield, Jack E. Baldwin, Karl Harlos, 2000, Nature Structural Biology.

A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene

Roger D. Cox, Christopher J. Schofield, Frances M. Ashcroft, 2009, PLoS genetics.

Oxygen sensing by HIF hydroxylases

Christopher J. Schofield, P. Ratcliffe, C. Schofield, 2004, Nature Reviews Molecular Cell Biology.

A Code for RanGDP Binding in Ankyrin Repeats Defines a Nuclear Import Pathway

Chris P. Ponting, Christopher J. Schofield, David T. Severson, 2014, Cell.

The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase

Chris P. Ponting, Christopher J. Schofield, Patrik Rorsman, 2007, Science.

The Mechanism of ACV Synthetase.

Christopher J. Schofield, Jack E. Baldwin, Chia-Yang Shiau, 1997, Chemical reviews.

Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases*

Chris P. Ponting, Christopher J. Schofield, Nicholas E. Ilott, 2016, The Journal of Biological Chemistry.

Development and application of ligand-based NMR screening assays for γ-butyrobetaine hydroxylase†‡

Hwanho Choi, Christopher J. Schofield, Timothy D. W. Claridge, 2016 .

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells

Akane Kawamura, Christopher J. Schofield, Faith Davies, 2017, Cell chemical biology.

Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers

Timothy R. Walsh, Christopher J. Schofield, Opher Gileadi, 2015, Antimicrobial Agents and Chemotherapy.

Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches†

Christopher J. Schofield, Udo Oppermann, Nathan R. Rose, 2010, Journal of medicinal chemistry.