A. Bitto

A. Bitto, L. Minutoli, D. Altavilla, 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Effects of the phytoestrogen genistein on hot flushes, endometrium, and vaginal epithelium in postmenopausal women: a 1-year randomized, double-blind, placebo-controlled study

A. Bitto, L. Minutoli, D. Altavilla, 2007, Menopause.

Polydeoxyribonucleotide (PDRN): a safe approach to induce therapeutic angiogenesis in peripheral artery occlusive disease and in diabetic foot ulcers.

A. Bitto, N. Irrera, L. Minutoli, 2009, Cardiovascular & hematological agents in medicinal chemistry.

MAO-A Inhibition by Metaxalone Reverts IL-1β-Induced Inflammatory Phenotype in Microglial Cells

A. Bitto, N. Irrera, L. Minutoli, 2021, International journal of molecular sciences.

Polydeoxyribonucleotide restores blood flow in an experimental model of ischemic skin flaps.

A. Bitto, N. Irrera, D. Altavilla, 2012, Journal of vascular surgery.

Activation of adenosine A2A receptors by polydeoxyribonucleotide increases vascular endothelial growth factor and protects against testicular damage induced by experimental varicocele in rats.

A. Bitto, N. Irrera, L. Minutoli, 2011, Fertility and sterility.

Genistein Supplementation and Cardiac Function in Postmenopausal Women with Metabolic Syndrome: Results from a Pilot Strain-Echo Study

A. Alibrandi, A. Bitto, D. Altavilla, 2017, Nutrients.

RANK-L is a Potential Therapeutic Target in Homogeneous Atherosclerotic Plaques

A. Bitto, D. Altavilla, F. Squadrito, 2018 .

Adenosine receptor stimulation by polynucleotides (PDRN) reduces inflammation in experimental periodontitis.

A. Bitto, N. Irrera, L. Minutoli, 2013, Journal of clinical periodontology.

Effects of genistein on hot flushes in early postmenopausal women: a randomized, double-blind EPT- and placebo-controlled study.

A. Bitto, D. Altavilla, F. Squadrito, 2004, Menopause.

Evaluation of CYP450 inhibitory effects and steady-state pharmacokinetics of genistein in combination with cholecalciferol and citrated zinc bisglycinate in postmenopausal women

A. Bitto, F. Squadrito, R. Levy, 2011, International journal of women's health.

Genistein in the metabolic syndrome: results of a randomized clinical trial.

D. Cucinotta, A. Bitto, L. Minutoli, 2013, The Journal of clinical endocrinology and metabolism.

Flavocoxid counteracts muscle necrosis and improves functional properties in mdx mice: A comparison study with methylprednisolone

A. Musarò, A. Bitto, N. Irrera, 2009, Experimental Neurology.

Steady-State Serum-Concentration of Genistein-Aglycone Is Affected by Formulation: BoneProducts Bioequivalence-Study

A. Bitto, D. Altavilla, F. Squadrito, 2020 .

Genistein Aglycone Demonstrates a Protective and Reversible Effect on the Development of Steroid-Induced Secondary Osteoporosis and Increases Bone Breaking Strength in Vivo

A. Bitto, N. Irrera, D. Altavilla, 2010 .

A mulTITARgeTeD INHIBITIoN oF THe ATHeRoSCleRoTIC PRoCeSS BY FuRoXAN-BASeD ANTIPRolIFeRATIVe AND ANTIoXIDANT HYBRIDS: A STuDY oN SmooTH muSCle Cell PRolIFeRATIoN

A. Bitto, N. Irrera, D. Altavilla, 2013 .

Estrogenic followed by anti-estrogenic effects of PCBs exposure in juvenil fish (Spaurus aurata).

A. Bitto, D. Alberghina, P. Lo Cascio, 2010, Food and Chemical Toxicology.

New-Onset Atrial Fibrillation and Early Mortality Rate in COVID-19 Patients: Association with IL-6 Serum Levels and Respiratory Distress

A. Bitto, N. Irrera, S. Gangemi, 2022, Medicina.

Flavocoxid, a Nutraceutical Approach to Blunt Inflammatory Conditions

A. Bitto, N. Irrera, D. Altavilla, 2014, Mediators of inflammation.

Trehalose: a biophysics approach to modulate the inflammatory response during endotoxic shock.

A. Bitto, L. Minutoli, D. Altavilla, 2008, European journal of pharmacology.

Autologous Haematopoietic Stem Cell Transplantation and Systemic Sclerosis: Focus on Interstitial Lung Disease

A. Allegra, G. Pioggia, A. Bitto, 2022, Cells.

Lipid peroxidation activates mitogen-activated protein kinases in testicular ischemia-reperfusion injury.

A. Bitto, L. Minutoli, D. Altavilla, 2006, The Journal of urology.

Evidence for a Role of Mitogen-Activated Protein Kinase 3/Mitogen-Activated Protein Kinase in the Development of Testicular Ischemia-Reperfusion Injury

A. Bitto, L. Minutoli, D. Altavilla, 2005, Biology of reproduction.

EPAC in Vascular Smooth Muscle Cells

A. Bitto, F. Kobeissy, A. Eid, 2020, International journal of molecular sciences.

Antioxidant effect of atorvastatin is independent of PON1 gene T(-107)C, Q192R and L55M polymorphisms in hyper cholesterolaemic patients hyper cholesterolaemic patients

A. Bitto, S. Campo, C. Saitta, 2005 .

Atherosclerosis Plaque Reduction by Lycopene Is Mediated by Increased Energy Expenditure through AMPK and PPARα in ApoE KO Mice Fed with a High Fat Diet

A. Bitto, N. Irrera, D. Altavilla, 2022, Biomolecules.

Dual αvβ3 and αvβ5 blockade attenuates fibrotic and vascular alterations in a murine model of systemic sclerosis.

A. Bitto, N. Irrera, D. Altavilla, 2017, Clinical science.

Targeting Adenosine Receptor by Polydeoxyribonucleotide: An Effective Therapeutic Strategy to Induce White-to-Brown Adipose Differentiation and to Curb Obesity

A. Bitto, N. Irrera, L. Minutoli, 2021, Pharmaceuticals.

Flavocoxid Inhibits Phospholipase A2, Peroxidase Moieties of the Cyclooxygenases (COX), and 5-Lipoxygenase, Modifies COX-2 Gene Expression, and Acts as an Antioxidant

A. Bitto, D. Altavilla, F. Squadrito, 2011, Mediators of inflammation.

Update on genistein and thyroid: an overall message of safety

A. Bitto, F. Squadrito, S. Benvenga, 2012, Front. Endocrin..

Beta‐arrestin 2 negatively regulates sepsis‐induced inflammation

A. Bitto, L. Luttrell, B. Zingarelli, 2010, Immunology.

Exploiting Curcumin Synergy With Natural Products Using Quantitative Analysis of Dose–Effect Relationships in an Experimental In Vitro Model of Osteoarthritis

A. Bitto, N. Irrera, L. Minutoli, 2019, Front. Pharmacol..

HPLC‐DAD Analysis, Antioxidant and Protective Effects of Tunisian Rhanterium suaveolens against Acetamiprid Induced Oxidative Stress on Mice Erythrocytes

A. Bitto, C. Kallel, H. Sellami, 2019, Chemistry & biodiversity.

Cardiovascular effects of the phytoestrogen genistein.

A. Bitto, D. Altavilla, F. Squadrito, 2004, Current medicinal chemistry. Cardiovascular and hematological agents.

Propylthiouracil prevents cutaneous&pulmonary-fibrosis in the ROS murine-model of systemic-sclerosis

A. Bitto, N. Irrera, D. Altavilla, 2020 .

Propylthiouracil modulates aortic vasculopathy in the oxidative stress model of systemic sclerosis.

A. Bitto, D. Altavilla, F. Squadrito, 2015, Vascular pharmacology.

Propylthiouracil prevents cutaneous and pulmonary fibrosis in the reactive oxygen species murine model of systemic sclerosis

A. Bitto, N. Irrera, D. Altavilla, 2013, Arthritis Research & Therapy.

A Phase 1/2 Study of Flavocoxid, an Oral NF-κB Inhibitor, in Duchenne Muscular Dystrophy

A. Bitto, F. Squadrito, S. Messina, 2021, Brain sciences.

A Dual Inhibitor of Cyclooxygenase and 5-Lipoxygenase Protects Against Kainic Acid-Induced Brain Injury

A. Bitto, N. Irrera, L. Minutoli, 2015, NeuroMolecular Medicine.

Flavocoxid, a dual inhibitor of cyclooxygenase‐2 and 5‐lipoxygenase, reduces pancreatic damage in an experimental model of acute pancreatitis

A. Bitto, N. Irrera, L. Minutoli, 2010, British journal of pharmacology.

ApoptosisProteins Inhibitors in experimental BenignProstaticHyperplasia:effects of SerenoaRepens,Selenium,Lycopene

A. Bitto, N. Irrera, L. Minutoli, 2020 .

GenisteinSupplementation, CardiacFunction in Postmenopausal-Women with MetabolicSyndrome: Results from Pilot-Strain-Echo Study

A. Alibrandi, A. Bitto, D. Altavilla, 2020 .

Visfatin correlates with hot flashes in postmenopausal women with metabolic syndrome: effects of genistein

A. Alibrandi, A. Bitto, L. Minutoli, 2017, Endocrine.

The ESR2 AluI 1730G>A (rs4986938) gene polymorphism is associated with fibrinogen plasma levels in postmenopausal women.

A. Alibrandi, A. Bitto, D. Altavilla, 2012, Gene.

Genistein aglycone: a dual mode of action anti-osteoporotic soy isoflavone rebalancing bone turnover towards bone formation.

A. Bitto, N. Irrera, L. Minutoli, 2010, Current medicinal chemistry.

Protective effect of genistein aglycone on the development of osteonecrosis of the femoral head and secondary osteoporosis induced by methylprednisolone in rats.

A. Bitto, L. Minutoli, D. Altavilla, 2009, The Journal of endocrinology.

Genistein aglycone does not affect thyroid function: results from a three-year, randomized, double-blind, placebo-controlled trial.

A. Bitto, L. Minutoli, D. Altavilla, 2010, The Journal of clinical endocrinology and metabolism.

Involvement of mitogen-activated protein kinases (MAPKs) during testicular ischemia-reperfusion injury in nuclear factor-kappaB knock-out mice.

A. Bitto, L. Minutoli, D. Altavilla, 2007, Life sciences.

Recombinant human erythropoietin stimulates angiogenesis and wound healing in the genetically diabetic mouse.

D. Cucinotta, G. Russo, A. Bitto, 2004, Diabetes.

RECOMBINANT HUMAN ERYTHROPOIETIN STIMULATES ANGIOGENESIS AND HEALING OF ISCHEMIC SKIN WOUNDS

A. Bitto, D. Altavilla, F. Squadrito, 2004, Shock.

on Some CardiovascularRisk Biomarkers in Postmenopausal-Women

Corrado, A. Bitto, Francesco, 2020 .

Effects of the phytoestrogen genistein on the circulating soluble receptor activator of nuclear factor kappaB ligand-osteoprotegerin system in early postmenopausal women.

A. Bitto, D. Altavilla, F. Squadrito, 2004, The Journal of clinical endocrinology and metabolism.

High mobility group box-1 expression correlates with poor outcome in lung injury patients.

A. Bitto, A. Ottani, L. Minutoli, 2010, Pharmacological research.

Adenosine Receptor Stimulation Improves Glucocorticoid-Induced Osteoporosis in a Rat Model

A. Bitto, N. Irrera, D. Altavilla, 2017, Frontiers in Pharmacology.

BAY 11-7082 inhibits the NF-κB and NLRP3 inflammasome pathways and protects against IMQ-induced psoriasis.

A. Bitto, N. Irrera, L. Minutoli, 2017, Clinical science.

Takotsubo syndrome and estrogen receptor genes: partners in crime?

A. Bitto, D. Altavilla, F. Squadrito, 2017, Journal of cardiovascular medicine.

The ESR2 AluI gene polymorphism is associated with bone mineral density in postmenopausal women

A. Alibrandi, A. Bitto, D. Altavilla, 2011, The Journal of Steroid Biochemistry and Molecular Biology.

Lipid peroxidation triggers both c-Jun N-terminal kinase (JNK) and extracellular-regulated kinase (ERK) activation and neointimal hyperplasia induced by cessation of blood flow in the mouse carotid artery.

A. Bitto, L. Minutoli, D. Altavilla, 2005, Atherosclerosis.

A New Supplement for the Treatment of Metabolic Syndrome in Postmenopausal Women

A. Bitto, R. Granese, V. Arcoraci, 2020, Food and Nutrition Sciences.

Emerging Evidence and Treatment Perspectives from Randomized Clinical Trials in Systemic Sclerosis: Focus on Interstitial Lung Disease

M. Tringali, A. Bitto, N. Irrera, 2022, Biomedicines.

Protective effects of SP600125 a new inhibitor of c-jun N-terminal kinase (JNK) and extracellular-regulated kinase (ERK1/2) in an experimental model of cerulein-induced pancreatitis.

A. Bitto, L. Minutoli, D. Altavilla, 2004, Life sciences.

Role of Cytokines in Vitiligo: Pathogenesis and Possible Targets for Old and New Treatments

A. Bitto, N. Irrera, D. Altavilla, 2021, International journal of molecular sciences.

Flavocoxid, a dual inhibitor of cyclooxygenase and 5‐lipoxygenase, blunts pro‐inflammatory phenotype activation in endotoxin‐stimulated macrophages

A. Bitto, L. Minutoli, D. Altavilla, 2009, British journal of pharmacology.

Genistein aglycone effect on bone loss is not enhanced by supplemental calcium and vitamin D3: a dose ranging experimental study.

A. Bitto, N. Irrera, L. Minutoli, 2011, Phytomedicine : international journal of phytotherapy and phytopharmacology.

AntagomiRs-15b&200b Effects on altered healing pattern of diabetic-mice

G. Russo, A. Bitto, N. Irrera, 2020 .

Effects of the antagomiRs 15b and 200b on the altered healing pattern of diabetic mice

G. Russo, A. Bitto, N. Irrera, 2018, British journal of pharmacology.

High-molecular weight hyaluronan reduced renal PKC activation in genetically diabetic mice.

A. Bitto, D. Altavilla, F. Squadrito, 2010, Biochimica et biophysica acta.

β-Caryophyllene MitigatesCAIA in Mice Through Cross-TalkBetweenCB2– PPAR-γReceptors

A. Bitto, N. Irrera, 2020 .

β-Caryophyllene Mitigates CAIA in Mice Through Cross-Talk CB2–PPAR-γReceptors

A. Bitto, N. Irrera, Vincenzo Arcoraci Letteria Minutoli Giuseppe M. Campo Angel Mario, 2020 .

β-Caryophyllene Mitigates Collagen Antibody Induced Arthritis (CAIA) in Mice Through a Cross-Talk between CB2 and PPAR-γ Receptors

A. Bitto, N. Irrera, L. Minutoli, 2019, Biomolecules.

The Nutraceutical Genistein-Lycopene Combination Improves Bone Damage Induced by Glucocorticoids by Stimulating the Osteoblast Formation Process

A. Bitto, N. Irrera, F. Squadrito, 2022, Nutrients.

PDRN-Activated A2A-Receptor Reduces NeuronalDamage, Stimulates WNT/β-CATENIN-Driven-Neurogenesis in Spinal-Cord-Injury

A. Bitto, N. Irrera, 2020 .

PDRN Ameliorates Imiquimod-Induced Psoriasis through NF- κBPathwayInhibition and Wnt/β-CateninSignalingModulation

A. Bitto, 2020 .

Lack of the Nlrp3 Inflammasome Improves Mice Recovery Following Traumatic Brain Injury

A. Bitto, N. Irrera, L. Minutoli, 2017, Front. Pharmacol..

Polydeoxyribonucleotide reduces cytokine production and the severity of collagen-induced arthritis by stimulation of adenosine A(₂A) receptor.

A. Bitto, N. Irrera, L. Minutoli, 2011, Arthritis and rheumatism.

Flavocoxid Protects Blood-Testis-Barrier against Cadmium-Induced-Disruption, Improves Testicular-Damage&Germ-Cell-Impairment in Mice

A. Bitto, Minutoli, 2020 .

Polydeoxyribonucleotide, an Adenosine-A2A Receptor Agonist, Preserves Blood Testis Barrier from Cadmium-Induced Injury

A. Bitto, N. Irrera, L. Minutoli, 2017, Front. Pharmacol..

Flavocoxid Protects Against Cadmium-Induced Disruption of the Blood–Testis Barrier and Improves Testicular Damage and Germ Cell Impairment in Mice [corrected].

A. Bitto, N. Irrera, L. Minutoli, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Tissue factor expression and activity are not increased in peripheral monocytes isolated from uncomplicated hypertensive patients

A. Bitto, S. Campo, C. Saitta, 2006, Journal of hypertension.

Effects of phytoestrogen genistein on cytogenetic biomarkers in postmenopausal women: 1 year randomized, placebo-controlled study.

A. Bitto, F. Squadrito, M. Buemi, 2008, European journal of pharmacology.

THE DISACCHARIDE TREHALOSE INHIBITS PROINFLAMMATORY PHENOTYPE ACTIVATION IN MACROPHAGES AND PREVENTS MORTALITY IN EXPERIMENTAL SEPTIC SHOCK

A. Bitto, L. Minutoli, D. Altavilla, 2007, Shock.

Cadmium delays puberty onset and testis growth in adolescents

A. Bitto, N. Irrera, L. Minutoli, 2015, Clinical endocrinology.

Simvastatin prevents vascular complications in the chronic reactive oxygen species murine model of systemic sclerosis

G. Russo, A. Bitto, N. Irrera, 2016, Free radical research.

Peroxisome proliferator activated receptor beta/delta activation prevents extracellular regulated kinase 1/2 phosphorylation and protects the testis from ischemia and reperfusion injury.

A. Bitto, N. Irrera, L. Minutoli, 2009, The Journal of urology.

Evidence for using a dual COX 1/2 and 5-LOX inhibitor in neurodegenerative diseases

A. Bitto, N. Irrera, 2017, Neural regeneration research.

Epoetin Alpha and Epoetin Zeta: A Comparative Study on Stimulation of Angiogenesis and Wound Repair in an Experimental Model of Burn Injury

A. Bitto, N. Irrera, L. Minutoli, 2015, BioMed research international.

Polyethylene glycol formulations show different soft tissue remodeling and angiogenesis features.

A. Bitto, F. Squadrito, G. Oteri, 2015, Tissue engineering. Part A.

HeavyMetals Levels in Adolescents of Industrialised-Area Milazzo-Valle del

A. Bitto, N. Irrera, L. Minutoli, 2020 .

CO2 pneumoperitoneum impact on early liver and lung cytokine expression in a rat model of abdominal sepsis

A. Bitto, N. Irrera, D. Altavilla, 2012, Surgical Endoscopy.

Polymorphisms Involved in Response to Biological Agents Used in Rheumatoid Arthritis

A. Bitto, N. Irrera, F. Squadrito, 2020, Biomolecules.

Effects of polydeoxyribonucleotide on the histological damage and the altered spermatogenesis induced by testicular ischaemia and reperfusion in rats.

A. Bitto, L. Minutoli, D. Altavilla, 2012, International journal of andrology.

Melanocortin 4 receptor activation protects against testicular ischemia-reperfusion injury by triggering the cholinergic antiinflammatory pathway.

Luca Spaccapelo, A. Bitto, A. Ottani, 2011, Endocrinology.

Raxofelast, a hydrophilic vitamin e-like antioxidant, reduces testicular ischemia-reperfusion injury

A. Bitto, D. Altavilla, F. Squadrito, 2004, Urological Research.

Oxidative Stress: Harms and Benefits for Human Health

A. Bitto, N. Irrera, D. Altavilla, 2017, Oxidative medicine and cellular longevity.

Characterization, antioxidant and protective effects of edible Rumex roseus on erythrocyte oxidative damage induced by methomyl

A. Bitto, R. Gdoura, N. Allouche, 2019, Journal of Food Measurement and Characterization.

ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis Ischemia/Reperfusion Injury

A. Bitto, N. Irrera, L. Minutoli, 2016, Oxidative medicine and cellular longevity.

Effects of flavocoxid, a dual inhibitor of COX and 5‐lipoxygenase enzymes, on benign prostatic hyperplasia

A. Bitto, N. Irrera, L. Minutoli, 2012, British journal of pharmacology.

Anti-Inflammatory Effects of the Methanol Extract of Sedum telephium ssp. maximum in Lipopolysaccharide- Stimulated Rat Peritoneal Macrophages

A. Bitto, L. Minutoli, D. Altavilla, 2008, Pharmacology.

Melanocortins protect against progression of Alzheimer's disease in triple-transgenic mice by targeting multiple pathophysiological pathways

A. Bitto, M. Galantucci, A. Ottani, 2014, Neurobiology of Aging.

Both early and delayed treatment with melanocortin 4 receptor-stimulating melanocortins produces neuroprotection in cerebral ischemia.

A. Bitto, L. Minutoli, D. Altavilla, 2006, Endocrinology.

Simvastatin enhances VEGF production and ameliorates impaired wound healing in experimental diabetes.

A. Bitto, L. Minutoli, D. Altavilla, 2008, Pharmacological research.

Cytochrome P450 (CYP1A) induction in sea bream (Sparus Aurata) gills and liver following exposure to polychlorobiphenyls (PCBs)

A. Bitto, L. Minutoli, D. Altavilla, 2009, Veterinary Research Communications.

New Approaches and Repurposed Antiviral Drugs for the Treatment of the SARS-CoV-2 Infection

A. Bitto, Luana Vittoria Bauso, Chiara Imbesi, 2021, Pharmaceuticals.

Genistein aglycone, a soy‐derived isoflavone, improves skin changes induced by ovariectomy in rats

A. Bitto, N. Irrera, L. Minutoli, 2012, British journal of pharmacology.

Systemic administration of high-molecular weight hyaluronan stimulates wound healing in genetically diabetic mice.

A. Bitto, N. Irrera, L. Minutoli, 2011, Biochimica et biophysica acta.

Flavocoxid exerts a potent antiviral effect against hepatitis B virus

A. Bitto, N. Irrera, L. Minutoli, 2017, Inflammation Research.

The Steady-State Serum Concentration of Genistein Aglycone Is Affected by Formulation: A Bioequivalence Study of Bone Products

A. Bitto, D. Altavilla, F. Squadrito, 2012, BioMed research international.

The PREdictor of MAlnutrition in Systemic Sclerosis (PREMASS) Score: A Combined Index to Predict 12 Months Onset of Malnutrition in Systemic Sclerosis

A. Bitto, N. Irrera, F. Squadrito, 2021, Frontiers in Medicine.

NLRP3 Inflammasome Involvement in the Organ Damage and Impaired Spermatogenesis Induced by Testicular Ischemia and Reperfusion in Mice

A. Bitto, N. Irrera, L. Minutoli, 2015, The Journal of Pharmacology and Experimental Therapeutics.

The combination of Serenoa repens, selenium and lycopene is more effective than serenoa repens alone to prevent hormone dependent prostatic growth.

A. Bitto, N. Irrera, L. Minutoli, 2011, The Journal of urology.

Epigenetic Modifications Due to Heavy Metals Exposure in Children Living in Polluted Areas

A. Bitto, N. Irrera, F. Squadrito, 2014, Current genomics.

IL-13 and IL-33 Serum Levels Are Increased in Systemic Sclerosis Patients With Interstitial Lung Disease

A. Bitto, N. Irrera, S. Gangemi, 2022, Frontiers in Medicine.

ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis Ischemia/Reperfusion Injury

A. Bitto, N. Irrera, L. Minutoli, 2016, Oxidative medicine and cellular longevity.

Erratum: Flavocoxid Protects Against Cadmium-Induced Disruption of the Blood-Testis Barrier and Improves Testicular Damage and Germ Cell Impairment in Mice.

A. Bitto, N. Irrera, L. Minutoli, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Effects of a New Flavonoid and Myo-Inositol Supplement on Some Biomarkers of Cardiovascular Risk in Postmenopausal Women: A Randomized Trial

A. Bitto, R. Granese, F. Corrado, 2014, International journal of endocrinology.

Inhibition of lipid peroxidation by IRFI 042, a vitamin E analogue, decreases monensin cardiotoxicity in chicks.

A. Bitto, L. Minutoli, D. Altavilla, 2005, Toxicology and applied pharmacology.

Biglycan Involvement in Heart Fibrosis: Modulation of Adenosine 2A Receptor Improves Damage in Immortalized Cardiac Fibroblasts

A. Bitto, N. Irrera, L. Minutoli, 2023, International journal of molecular sciences.

Biglycan expression in hypertensive subjects with normal or increased carotid intima-media wall thickness.

A. Alibrandi, A. Bitto, S. Campo, 2009, Clinica chimica acta; international journal of clinical chemistry.

Pharmacological Activity and Clinical Use of PDRN

A. Bitto, N. Irrera, L. Minutoli, 2017, Front. Pharmacol..

The effect of PDRN, an adenosine receptor A2A agonist, on the healing of chronic diabetic foot ulcers: results of a clinical trial.

D. Cucinotta, A. Bitto, L. Minutoli, 2014, The Journal of clinical endocrinology and metabolism.

Activation of adenosine A2A receptors restores the altered cell-cycle machinery during impaired wound healing in genetically diabetic mice.

A. Bitto, N. Irrera, L. Minutoli, 2011, Surgery.

Polydeoxyribonucleotide improves angiogenesis and wound healing in experimental thermal injury

A. Bitto, L. Minutoli, D. Altavilla, 2008, Critical care medicine.

Polydeoxyribonucleotide stimulates angiogenesis and wound healing in the genetically diabetic mouse

A. Bitto, L. Minutoli, D. Altavilla, 2008, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

Blockade of the JNK Signalling as a Rational Therapeutic Approach to Modulate the Early and Late Steps of the Inflammatory Cascade in Polymicrobial Sepsis

A. Bitto, N. Irrera, L. Minutoli, 2015, Mediators of inflammation.

Protective effects of IRFI-042 in monensin induced neurotoxicity in chicks.

A. Bitto, L. Minutoli, D. Altavilla, 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Modulation of IL-1 β gene expression by lipid peroxidation inhibition after kainic acid-induced rat brain injury

M. Bellomo, A. Bitto, L. Minutoli, 2004, Experimental Neurology.

Inhibitors of apoptosis proteins in experimental benign prostatic hyperplasia: effects of serenoa repens, selenium and lycopene

A. Bitto, N. Irrera, L. Minutoli, 2014, Journal of Biomedical Science.

Role of Inhibitors of Apoptosis Proteins in Testicular Function and Male Fertility: Effects of Polydeoxyribonucleotide Administration in Experimental Varicocele

A. Bitto, N. Irrera, L. Minutoli, 2015, BioMed research international.

Effects of the Phytoestrogen Genistein on Bone Metabolism in Osteopenic Postmenopausal Women

A. Bitto, L. Minutoli, D. Altavilla, 2007, Annals of Internal Medicine.

PDRN, a Bioactive Natural Compound, Ameliorates Imiquimod-Induced Psoriasis through NF-κB Pathway Inhibition and Wnt/β-Catenin Signaling Modulation

A. Bitto, N. Irrera, L. Minutoli, 2020, International journal of molecular sciences.

Levels of Heavy Metals in Adolescents Living in the Industrialised Area of Milazzo-Valle del Mela (Northern Sicily)

A. Bitto, N. Irrera, L. Minutoli, 2014, Journal of environmental and public health.

Adenosine Receptor Stimulation by Polydeoxyribonucleotide Improves Tissue Repair and Symptomology in Experimental Colitis

A. Bitto, N. Irrera, D. Altavilla, 2016, Front. Pharmacol..

Genistein reduces angiogenesis and apoptosis in women with endometrial hyperplasia

A. Bitto, F. Squadrito, R. Granese, 2015 .

Genistein aglycone: a new therapeutic approach to reduce endometrial hyperplasia.

A. Bitto, D. Altavilla, F. Squadrito, 2010, Phytomedicine : international journal of phytotherapy and phytopharmacology.

VEGF overexpression via adeno‐associated virus gene transfer promotes skeletal muscle regeneration and enhances muscle function in mdx mice

L. Zentilin, M. Giacca, A. Bitto, 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Melanocortin 4 receptor stimulation decreases pancreatitis severity in rats by activation of the cholinergic anti-inflammatory pathway*

Luca Spaccapelo, A. Bitto, A. Ottani, 2011, Critical care medicine.

Simvastatin attenuates the development of pulmonary and cutaneous fibrosis in a murine model of systemic sclerosis.

A. Bitto, N. Irrera, D. Altavilla, 2013, Rheumatology.

Evidence for using a dual COX1/2 & 5-LOX inhibitor in NeurodegenerativeDiseases

A. Bitto, 2020 .

Effects of COX1-2/5-LOX blockade in Alzheimer transgenic 3xTg-AD mice

A. Bitto, A. Ottani, N. Irrera, 2017, Inflammation Research.

The Role of NLRP3 Inflammasome in the Pathogenesis of Traumatic Brain Injury

A. Bitto, N. Irrera, L. Minutoli, 2020, International journal of molecular sciences.

Correction: Propylthiouracil prevents cutaneous and pulmonary fibrosis in the reactive oxygen species murine model of systemic sclerosis

A. Bitto, N. Irrera, D. Altavilla, 2013, Arthritis Research & Therapy.

Oxidative stress and DNA repair and detoxification gene expression in adolescents exposed to heavy metals living in the Milazzo-Valle del Mela area (Sicily, Italy)

A. Bitto, N. Irrera, L. Minutoli, 2014, Redox biology.

Melanocortins protect against brain damage and counteract cognitive decline in a transgenic mouse model of moderate Alzheimer׳s disease.

A. Bitto, M. Galantucci, A. Ottani, 2014, European journal of pharmacology.

Melanocortins as potential therapeutic agents in severe hypoxic conditions

Luca Spaccapelo, A. Bitto, M. Galantucci, 2012, Frontiers in Neuroendocrinology.

Protective effects of melanocortins on short-term changes in a rat model of traumatic brain injury*

Luca Spaccapelo, A. Bitto, A. Ottani, 2012, Critical care medicine.

Melanocortins protect against multiple organ dysfunction syndrome in mice

Luca Spaccapelo, A. Bitto, M. Galantucci, 2011, British journal of pharmacology.

Vagus Nerve Mediates the Protective Effects of Melanocortins against Cerebral and Systemic Damage after Ischemic Stroke

A. Bitto, M. Galantucci, A. Ottani, 2009, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Neuroprotection in focal cerebral ischemia owing to delayed treatment with melanocortins.

A. Bitto, M. Galantucci, A. Ottani, 2007, European journal of pharmacology.

Broad therapeutic treatment window of [Nle(4), D-Phe(7)]alpha-melanocyte-stimulating hormone for long-lasting protection against ischemic stroke, in Mongolian gerbils.

A. Bitto, M. Galantucci, L. Minutoli, 2006, European journal of pharmacology.

Activation of an efferent cholinergic pathway produces strong protection against myocardial ischemia/reperfusion injury in rats*

A. Bitto, L. Minutoli, D. Altavilla, 2005, Critical care medicine.

Evidence for markers of hypoxia and apoptosis in explanted human carotid atherosclerotic plaques.

A. Bitto, N. Irrera, D. Altavilla, 2010, Journal of vascular surgery.

Non-covalent immunoproteasome inhibitors induce cell cycle arrest in multiple myeloma MM.1R cells

A. Bitto, N. Irrera, D. Altavilla, 2019, Journal of enzyme inhibition and medicinal chemistry.

Combined Treatment with Polynucleotides and Hyaluronic Acid Improves Tissue Repair in Experimental Colitis

A. Bitto, N. Irrera, L. Minutoli, 2020, Biomedicines.

Reactive Oxygen Species: Modulators of Phenotypic Switch of Vascular Smooth Muscle Cells

A. Bitto, A. Eid, A. El-Yazbi, 2020, International journal of molecular sciences.

Inhibition of inflammasome activation improves the impaired pattern of healing in genetically diabetic mice

A. Bitto, N. Irrera, D. Altavilla, 2014, British journal of pharmacology.

Mechanisms underlying the effects of caloric restriction on hypertension.

A. Bitto, A. Orekhov, A. Eid, 2022, Biochemical pharmacology.

Lipid peroxidation inhibition blunts nuclear factor-kappaB activation, reduces skeletal muscle degeneration, and enhances muscle function in mdx mice.

A. Bitto, L. Minutoli, D. Altavilla, 2006, The American journal of pathology.

Poster session Wednesday 11 December all day display: 11/12/2013, 09:30-16:00 * Location: Poster area

J. C. Ortiz, A. Cuvelier, S. Ramakrishnan, 2013 .

Nuclear factor kappa-B blockade reduces skeletal muscle degeneration and enhances muscle function in Mdx mice

A. Bitto, L. Minutoli, D. Altavilla, 2006, Experimental Neurology.

Potential Role of microRNAs in inducing Drug Resistance in Patients with Multiple Myeloma

A. Allegra, A. Bitto, V. Innao, 2021, Cells.

Could Antigen Presenting Cells Represent a Protective Element during SARS-CoV-2 Infection in Children?

A. Bitto, N. Irrera, A. Eid, 2021, Pathogens.

Protective Effects of Antioxidant Raxofelast in Alcohol-Induced Liver Disease in Mice

A. Bitto, L. Minutoli, D. Altavilla, 2005, Pharmacology.

Mitogen-activated protein kinase 3/mitogen-activated protein kinase 1 activates apoptosis during testicular ischemia-reperfusion injury in a nuclear factor-kappaB-independent manner.

A. Bitto, L. Minutoli, D. Altavilla, 2009, European journal of pharmacology.

Flavonoids in adipose tissue inflammation and atherosclerosis: one arrow, two targets.

A. Bitto, A. Eid, E. Baydoun, 2020, Clinical science.

Skin Involvement and Pulmonary Hypertension Are Associated with Vitamin D Insufficiency in Scleroderma

A. Bitto, F. Squadrito, D. Santoro, 2016, International journal of molecular sciences.

Use of Drugs and Dietary Supplements in University Students of Sports Science: Results of a Survey-Based Cross-Sectional Study

A. Bitto, D. Di Mauro, F. Trimarchi, 2022, Nutrients.

Functional recovery after delayed treatment of ischemic stroke with melanocortins is associated with overexpression of the activity-dependent gene Zif268

A. Bitto, M. Galantucci, A. Ottani, 2009, Brain, Behavior, and Immunity.

Severe Acute Respiratory Syndrome Coronavirus-2 Induces Cytokine Storm and Inflammation During Coronavirus Disease 19: Perspectives and Possible Therapeutic Approaches

A. Bitto, N. Irrera, Federica Mannino, 2020, Frontiers in Pharmacology.

Genistein effects on quality of life and depression symptoms in osteopenic postmenopausal women: a 2-year randomized, double-blind, controlled study

A. Bitto, F. Squadrito, N. Frisina, 2014, Osteoporosis International.

Microsurgical arterovenous loops and biological templates: A novel in vivo chamber for tissue engineering

Stefano Geuna, Domenica Altavilla, Alessandra Bitto, 2007, Microsurgery.

Association between serum paraoxonase (PON1) gene promoter T(-107)C polymorphism, PON1 activity and HDL levels in healthy Sicilian octogenarians

A. Bitto, S. Campo, C. Saitta, 2004, Experimental Gerontology.

Anti-obesity drug therapy in clinical practice: Evidence of a poor prescriptive attitude.

A. Bitto, N. Irrera, L. Minutoli, 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

A Dual Inhibitor of Cyclooxygenase and 5-Lipoxygenase Protects Against Kainic Acid-Induced Brain Injury

A. Bitto, N. Irrera, L. Minutoli, 2015, NeuroMolecular Medicine.

HDL subclasses and the common CETP TaqIB variant predict the incidence of microangiopatic complications in type 2 diabetic women: A 9years follow-up study.

D. Cucinotta, G. Russo, A. Giandalia, 2017, Diabetes research and clinical practice.

Methotrexate Increases Skeletal Muscle GLUT4 Expression and Improves Metabolic Control in Experimental Diabetes

D. Cucinotta, G. Russo, A. Giandalia, 2012, Journal of nutrition and metabolism.

Role of Adenosine and Purinergic Receptors in Myocardial Infarction: Focus on Different Signal Transduction Pathways

A. Bitto, N. Irrera, F. Squadrito, 2021, Biomedicines.

Relaxin improves multiple markers of wound healing and ameliorates the disturbed healing pattern of genetically diabetic mice

A. Bitto, N. Irrera, L. Minutoli, 2013, Clinical science.

PCB-126 effects on aryl hydrocarbon receptor, ubiquitin and p53 expression levels in a fish product (Sparus aurata L.)

A. Bitto, D. Altavilla, F. Giarratana, 2018, Natural product research.

Increased Serum HMGB-1, ICAM-1 and Metalloproteinase-9 Levels in Buerger's Patients.

A. Bitto, D. Altavilla, F. Squadrito, 2016, Current Vascular Pharmacology.

Bicuspid aortic valve and aortopathy: novel prognostic predictors for the identification of high-risk patients.

A. Bitto, F. Squadrito, B. Khandheria, 2020, European heart journal cardiovascular Imaging.

Impairment of elastic properties of the aorta in bicuspid aortic valve: relationship between biomolecular and aortic strain patterns

A. Bitto, F. Squadrito, B. Khandheria, 2018, European heart journal cardiovascular Imaging.

Platelet activating factor-acetylhydrolase (PAF-AH) activity and HDL levels, but not PAF-AH gene polymorphisms, are associated with successful aging in Sicilian octogenarians

A. Bitto, S. Campo, C. Saitta, 2008, Aging clinical and experimental research.

Platelet activating factor-acetylhydrolase ( PAF-AH ) activity and HDL levels , but not PAF-AH gene polymorphisms , are associated with successful aging in Sicilian octogenarians Aging Clinical and Experimental Research

A. Bitto, S. Campo, C. Saitta, 2008 .

Anti-oxidant and anti-inflammatory effects of ellagic and punicic acid in an in vitro model of cardiac fibrosis.

A. Bitto, N. Irrera, L. Minutoli, 2023, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Neuroprotective Effects of Polydeoxyribonucleotide in a Murine Model of Cadmium Toxicity

A. Bitto, N. Irrera, L. Minutoli, 2018, Oxidative medicine and cellular longevity.

Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis

A. Bitto, N. Irrera, L. Minutoli, 2012, Critical Care.

Use of a balanced dual cyclooxygenase-1/2 and 5-lypoxygenase inhibitor in experimental colitis.

A. Bitto, N. Irrera, L. Minutoli, 2016, European journal of pharmacology.

Vitamin D Status and the Relationship with Bone Fragility Fractures in HIV-Infected Patients: A Case Control Study

A. Bitto, F. Squadrito, D. Santoro, 2018, International journal of molecular sciences.

Anti-Inflammatory, Antioxidant, and WAT/BAT-Conversion Stimulation Induced by Novel PPAR Ligands: Results from Ex Vivo and In Vitro Studies

A. Bitto, A. Cama, G. Orlando, 2023, Pharmaceuticals.

Medical simulation in pharmacology learning and retention: A comparison study with traditional teaching in undergraduate medical students

A. Alibrandi, A. Bitto, L. Minutoli, 2019, Pharmacology research & perspectives.

Activation of the EPOR-β common receptor complex by cibinetide ameliorates impaired wound healing in mice with genetic diabetes.

A. Bitto, N. Irrera, L. Minutoli, 2018, Biochimica et biophysica acta. Molecular basis of disease.

Recent Advances in Nanotherapeutics for Multiple Myeloma

A. Bitto, A. Eid, D. Iannazzo, 2020, Cancers.

ACTIVATION OF THE CHOLINERGIC ANTI-INFLAMMATORY PATHWAY REDUCES NF-&kgr;B ACTIVATION, BLUNTS TNF-&agr; PRODUCTION, AND PROTECTS AGAINTS SPLANCHIC ARTERY OCCLUSION SHOCK

A. Bitto, L. Minutoli, D. Altavilla, 2006, Shock.

Modulation of neuronal nitric oxide synthase and apoptosis by the isoflavone genistein in Mdx mice.

A. Bitto, N. Irrera, L. Minutoli, 2015, BioFactors.

Development of Novel Amides as Noncovalent Inhibitors of Immunoproteasomes

A. Bitto, E. Novellino, A. Lavecchia, 2019, ChemMedChem.

β-Caryophyllene Inhibits Cell Proliferation through a Direct Modulation of CB2 Receptors in Glioblastoma Cells

A. Bitto, N. Irrera, L. Minutoli, 2020, Cancers.

Angiopoietin-1 gene transfer improves impaired wound healing in genetically diabetic mice without increasing VEGF expression.

Domenica Altavilla, Alessandra Bitto, Francesca Polito, 2008, Clinical science.

Steady state plasma and tissue distribution of low molecular weight hyaluronic acid after oral administration in mice.

A. Bitto, N. Irrera, Federica Mannino, 2023, Natural product research.

Beta-Caryophyllene Exhibits Anti-Proliferative Effects through Apoptosis Induction and Cell Cycle Modulation in Multiple Myeloma Cells

A. Allegra, A. Bitto, N. Irrera, 2021, Cancers.

The paraoxonase promoter polymorphism (-107)T>C is not associated with carotid intima-media thickness in Sicilian hypercholesterolemic patients.

A. Bitto, S. Campo, C. Saitta, 2004, Clinical biochemistry.

Effects of genistein aglycone in glucocorticoid induced osteoporosis: A randomized clinical trial in comparison with alendronate.

A. Bitto, N. Irrera, F. Squadrito, 2023, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Beneficial Effects of Physical Activity in Rheumatoid Arthritis Patients: Focus on Active Biomolecules

Joseph N. Grima, A. Bitto, D. Di Mauro, 2023, Journal of Orthopaedics and Sports Medicine.

Immunoproteasome-Selective Inhibitors: A Promising Strategy to Treat Hematologic Malignancies, Autoimmune and Inflammatory Diseases.

A. Bitto, M. Zappalà, R. Ettari, 2016, Current Medicinal Chemistry.

Blunting Neuroinflammation by Targeting the Immunoproteasome with Novel Amide Derivatives

A. Bitto, N. Irrera, M. Zappalà, 2023, International journal of molecular sciences.

Identification of 2-thioxoimidazolidin-4-one derivatives as novel noncovalent proteasome and immunoproteasome inhibitors.

A. Bitto, R. Maccari, R. Ottanà, 2017, Bioorganic & medicinal chemistry letters.

Non-covalent immunoproteasome inhibitors induce cell-cycle arrest in MM.1R cells

A. Bitto, Roberta Ettari Giovanni Pallio Gabriele Pizzino Natasha Ir Domenica, Altavilla Francesco Squadrito Alessandra Bitto, 2020 .

Antioxidant effect of atorvastatin is independent of PON1 gene T(–107)C, Q192R and L55M polymorphisms in hypercholesterolaemic patients

A. Bitto, S. Campo, C. Saitta, 2005, Current medical research and opinion.

Cadmium-Induced Oxidative Stress Impairs Glycemic Control in Adolescents

A. Bitto, N. Irrera, L. Minutoli, 2017, Oxidative medicine and cellular longevity.

Failure of Achieving Tacrolimus Target Blood Concentration Might Be Avoided by a Wide Genotyping of Transplanted Patients: Evidence from a Retrospective Study

A. Alibrandi, A. Bitto, N. Irrera, 2020, Journal of personalized medicine.

Imbalance of serum cytokine network in sarcoid patients: index of sarcoidosis relapse?

A. Bitto, F. M. Salmeri, M. Gaeta, 2003, Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG.

Irisin and Vascular Inflammation: Beneficial Effects of a Healthy Lifestyle Around and Beyond Physical Activity.

A. Bitto, D. Di Mauro, F. Trimarchi, 2021, Current pharmaceutical design.

AB0197 Simvastatin Attenuates Aortic Thickness in the Chronic Reactive Oxygen Species Murine Model of Systemic Sclerosis

A. Bitto, D. Altavilla, F. Squadrito, 2014 .

Treatment of cerebral ischemia with melanocortins acting at MC4 receptors induces marked neurogenesis and long-lasting functional recovery

Luca Spaccapelo, A. Bitto, M. Galantucci, 2011, Acta Neuropathologica.

Effects of the phytoestrogen genistein on hot flushes, endometrium, and vaginal epithelium in postmenopausal women: a 1-year randomized, double-blind, placebo-controlled study

A. Bitto, L. Minutoli, D. Altavilla, 2007, Menopause.

Adenosine-Receptor-Stimulation Improves Glucocorticoid-Induced-Osteoporosis in a Rat Model

A. Bitto, 2020 .

Melanocortins protect against progression of Alzheimer's disease in triple-transgenic mice by targeting multiple pathophysiological pathways

A. Bitto, M. Galantucci, A. Ottani, 2014, Neurobiology of Aging.

The effect of PDRN, an adenosine receptor A2A agonist, on the healing of chronic diabetic foot ulcers: results of a clinical trial.

D. Cucinotta, A. Bitto, L. Minutoli, 2014, The Journal of clinical endocrinology and metabolism.

Modulation of neuronal nitric oxide synthase and apoptosis by the isoflavone genistein in Mdx mice.

A. Bitto, N. Irrera, L. Minutoli, 2015, BioFactors.

Serenoa Repens, lycopene and selenium: a triple therapeutic approach to manage benign prostatic hyperplasia.

A. Bitto, N. Irrera, L. Minutoli, 2013, Current medicinal chemistry.

Effects of PCB-126 on aryl hydrocarbon receptor, ubiquitin and p53 expression levels in Sparus aurata.

A. Bitto, D. Altavilla, F. Giarratana, 2017, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.

Beta-Caryophyllene, a Plant-Derived CB2 Receptor Agonist, Protects SH-SY5Y Cells from Cadmium-Induced Toxicity

A. Bitto, N. Irrera, L. Minutoli, 2023, International journal of molecular sciences.

Insights into the antiosteoporotic mechanism of the soy-derived isoflavone genistein: Modulation of the Wnt/beta-catenin signaling.

A. Bitto, N. Irrera, F. Squadrito, 2023, BioFactors.

Effects of the Phytoestrogen Genistein on Bone Metabolism in Osteopenic Postmenopausal Women

A. Bitto, L. Minutoli, D. Altavilla, 2007, Annals of Internal Medicine.

International Journal of Women's Health Dovepress Evaluation of Cyp450 Inhibitory Effects and Steady-state Pharmacokinetics of Genistein in Combination with Cholecalciferol and Citrated Zinc Bisglycinate in Postmenopausal Women

A. Bitto, F. Squadrito, R. Levy, 2022 .

NLRP3 Inflammasome Involvement in the Organ Damage and Impaired Spermatogenesis Induced by Testicular Ischemia and Reperfusion in Mice

A. Bitto, N. Irrera, L. Minutoli, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Inhibition of inflammasome activation improves the impaired pattern of healing in genetically diabetic mice

A. Bitto, N. Irrera, D. Altavilla, 2014, British journal of pharmacology.