M. Fleming

M. Fleming, H. Steen, R. Kwong, 2011, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Distinct genetic pathways define pre-leukemic and compensatory clonal hematopoiesis in Shwachman-Diamond syndrome

Nicholas D. Camarda, S. Carter, M. Norkin, 2020, bioRxiv.

Structure of the membrane proximal oxidoreductase domain of human Steap3, the dominant ferrireductase of the erythroid transferrin cycle

M. Fleming, C. M. Lawrence, A. Sendamarai, 2008, Proceedings of the National Academy of Sciences.

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

N. Andrews, M. Fleming, K. Finberg, 2008, Nature Genetics.

Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells

J. J. Sharp, M. Fleming, E. Greer, 2005, Nature Genetics.

Lymphomas of the breast

G. Pinkus, M. Fleming, S. Domchek, 2002, Cancer.

The molecular genetics of sideroblastic anemia.

M. Fleming, S. Ducamp, 2019, Blood.

Sideroblastic anemia: diagnosis and management.

M. Fleming, S. Bottomley, 2014, Hematology/oncology clinics of North America.

Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis.

M. Fleming, C. Pondarré, D. Campagna, 2007, Blood.

Regulation of Progenitor Cell Proliferation and Granulocyte Function by microRNA-223.

O. Kirak, M. Fleming, F. Camargo, 2007 .

CD4+/CD56+ hematodermic neoplasm ("blastic natural killer cell lymphoma"): neoplastic cells express the immature dendritic cell marker BDCA-2 and produce interferon.

G. Pinkus, M. Fleming, J. Pinkus, 2007, American journal of clinical pathology.

The genetics of inherited sideroblastic anemias.

M. Fleming, 2002, Seminars in hematology.

patients with HIV disease A polymorphism in the leptin gene promoter is associated with anemia in

J. Fellay, A. Telenti, M. Fleming, 2012 .

A polymorphism in the leptin gene promoter is associated with anemia in patients with HIV disease.

J. Fellay, A. Telenti, M. Fleming, 2011, Blood.

responsiveness expression reveal targets of damage, stress response, and antioxidant SOD2-deficiency anemia: protein oxidation and altered protein

Mary F. Lopez, M. Fleming, S. Doctrow, 2013 .

SOD2-deficiency anemia: protein oxidation and altered protein expression reveal targets of damage, stress response, and antioxidant responsiveness.

Mary F. Lopez, M. Fleming, S. Doctrow, 2004, Blood.

Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice

N. Andrews, M. Fleming, W. Dietrich, 2007, Nature Genetics.

A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd) mice

N. Andrews, M. Fleming, O. Jin, 2005, Nature Genetics.

A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice.

N. Andrews, M. Fleming, J. N. Haslett, 2001, Genes & development.

Characterization of a murine high-affinity thiamine transporter, Slc19a2.

G. Pinkus, M. Fleming, E. Neufeld, 2001, Molecular genetics and metabolism.

A physician or group of physicians considers presentation and evolution of a real clinical case, reacting to clinical information and data (boldface type). This is followed by a discussion/commentary Hereditary xerocytosis revisited

M. Fleming, D. Vandorpe, F. Sachs, 2014 .

differentiation progenitor cells and is required for epo regulation of erythroid cell AKT induces erythroid cell maturation of JAK2-deficient fetal liver

H. Lodish, M. Fleming, B. Luo, 2013 .

SLC25A38 congenital sideroblastic anemia: Phenotypes and genotypes of 31 individuals from 24 families, including 11 novel mutations, and a review of the literature

M. Fleming, J. Boudreaux, T. Olson, 2021, Human mutation.

The placenta: the forgotten essential organ of iron transport.

M. Fleming, Chang Cao, 2016, Nutrition reviews.

Transgenic HFE‐dependent induction of hepcidin in mice does not require transferrin receptor‐2

M. Fleming, P. Schmidt, M. D. Fleming, 2012, American journal of hematology.

A mouse model of juvenile hemochromatosis.

G. Pinkus, N. Andrews, M. Fleming, 2005, The Journal of clinical investigation.

Hereditaryhemochromatosisisaniron-overloaddisorderresultingfrommutationsinproteinspresumedto beinvolvedinthemaintenanceofironhomeostasis.Mutationsinhemojuvelin(HJV)causesevere,early-onset juvenilehemochromatosis.ThenormalfunctionofHJVisunknown.Juvenilehemochromatosispatientshave decreasedurinaryleve

G. Pinkus, N. Andrews, M. Fleming, 2005 .

Identification of a novel mutation (C321X) in HJV.

N. Andrews, M. Fleming, I. Rubio-Aliaga, 2004, Blood.

Hepcidin-Mediated Hypoferremia Disrupts Immune Responses to Vaccination and Infection

M. Fleming, V. Cerundolo, B. Galy, 2020, Med.

An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia.

S. Milstein, M. Fleming, B. Bettencourt, 2013, Blood.

thalassemia intermedia β mice and ameliorates anemia and iron overload in murine − / − Hfe An RNAi therapeutic targeting Tmprss 6 decreases iron overload in

S. Milstein, M. Fleming, B. Bettencourt, 2013 .

Global loss of Tfr2 with concomitant induced iron deficiency greatly ameliorates the phenotype of a murine thalassemia intermedia model

M. Fleming, K. Fitzgerald, James S. Butler, 2020, American journal of hematology.

Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice.

N. Andrews, M. Fleming, H. Gunshin, 2005, Blood.

The molecular defect in hypotransferrinemic mice.

N. Andrews, M. Fleming, C. Trenor, 2000, Blood.

Mild iron deficiency does not ameliorate the phenotype of a murine erythropoietic protoporphyria model

M. Fleming, M. Hollowell, K. Fitzgerald, 2020, American journal of hematology.

Normalizing hepcidin predicts TMPRSS6 mutation status in patients with chronic iron deficiency.

M. Fleming, K. Finberg, A. Iolascon, 2018, Blood.

Molecular insights into mechanisms of iron transport.

N. Andrews, M. Fleming, J. Levy, 1999, Current opinion in hematology.

Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport.

N. Andrews, M. Fleming, M. Garrick, 1998, Proceedings of the National Academy of Sciences of the United States of America.

mutation in the mouse nm1054: a spontaneous, recessive, hypochromic, microcytic anemia

J. J. Sharp, M. Fleming, D. Campagna, 2013 .

hem6: an ENU-induced recessive hypochromic microcytic anemia mutation in the mouse.

M. Justice, M. Fleming, D. Campagna, 2008, Blood.

nm1054: a spontaneous, recessive, hypochromic, microcytic anemia mutation in the mouse.

J. J. Sharp, M. Fleming, D. Campagna, 2005, Blood.

Hemojuvelin is essential for transferrin-dependent and transferrin-independent hepcidin expression in mice

M. Fleming, T. Bartnikas, 2012, Haematologica.

A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency

Toshiro K. Ohsumi, N. Andrews, M. Fleming, 2015, Nature Genetics.

Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins

B. Paw, M. Fleming, Julio D Amigo, 2008, Nature.

Red Cells Cybrd 1 ( duodenal cytochrome b ) is not necessary for dietary iron absorption in mice Running Head : Targeted disruption of Cybrd 1

N. Andrews, M. Fleming, H. Gunshin, 2005 .

IRON AND ERYTHROPOIESIS Lessons from Anemic Mice

N. Andrews, M. Fleming, 1999 .

Mammalian iron transport: an unexpected link between metal homeostasis and host defense.

N. Andrews, M. Fleming, 1998, Journal of Laboratory and Clinical Medicine.

The G 185 R Mutation Disrupts Function of the Iron Transporter Nramp 2

N. Andrews, M. Fleming, J. Fleming, 1998 .

A novel TERC CR4/CR5 domain mutation causes telomere disease via decreased TERT binding.

M. Fleming, Suneet Agarwal, C. Cutler, 2016, Blood.

Congenital sideroblastic anemias: iron and heme lost in mitochondrial translation.

M. Fleming, 2011, Hematology. American Society of Hematology. Education Program.

Clinical features and outcomes of patients with Shwachman-Diamond syndrome and myelodysplastic syndrome or acute myeloid leukaemia: a multicentre, retrospective, cohort study.

M. Norkin, M. Oberley, M. Fleming, 2019, The Lancet. Haematology.

Histologic and Laboratory Characteristics of Symptomatic and Asymptomatic Castleman Disease in the Pediatric Population.

M. Fleming, Karen M. Chisholm, 2020, American journal of clinical pathology.

Evidence for a protective role of the Gardos channel against hemolysis in murine spherocytosis.

M. Fleming, P. Gascard, L. De Franceschi, 2005, Blood.

Absence of Dendritic Reticulum Cell Staining Is Helpful for Distinguishing T-Cell-Rich B-Cell Lymphoma From Lymphocyte Predominance Hodgkin's Disease

M. Fleming, D. Dorfman, A. Shahsafaei, 1998 .

Congenital sideroblastic anemia due to mutations in the mitochondrial HSP70 homologue HSPA9.

Szymon J. Ciesielski, Meghan C Towne, P. Newburger, 2015, Blood.

Mutations in the iron-sulfur cluster biogenesis protein HSCB cause congenital sideroblastic anemia.

B. Paw, M. Fleming, J. Boudreaux, 2020, The Journal of clinical investigation.

Complicated and Advanced Atherosclerosis in a Young Woman With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Success and Challenges of BCR/ABL1-Targeted Cancer Therapy.

M. Bell, M. Fleming, A. Lerman, 2015, Mayo Clinic proceedings.

Induced Pluripotent Stem Cells with a Mitochondrial DNA Deletion

G. Daley, M. Fleming, E. Neufeld, 2013, Stem cells.

Hepcidin is not essential for mediating testosterone's effects on erythropoiesis

M. Fleming, S. Bhasin, P. Schmidt, 2020, Andrology.

An RNAi-Therapeutic Targeting Tmprss6, in Conjunction With Oral Chelator Therapy, Ameliorates Anemia and Additively Diminishes Secondary Iron Overload In a Mouse Model Of β-Thalassemia Intermedia

M. Fleming, T. Racie, K. Fitzgerald, 2013 .

ataxia, is essential for hematopoiesis Abcb7, the gene responsible for X-linked sideroblastic anemia with

M. Fleming, C. Pondarré, D. Campagna, 2013 .

SBDS protein expression patterns in the bone marrow

M. Fleming, M. Harris, A. Shimamura, 2010, Pediatric blood & cancer.

STEM CELLS ® EMBRYONIC STEM CELLS / INDUCED PLURIPOTENT STEM CELLS Induced Pluripotent Stem Cells with a Pathological Mitochondrial DNA Deletion

Gorman, G. Daley, M. Fleming, 2013 .

Genomic analysis of bone marrow failure and myelodysplastic syndromes reveals phenotypic and diagnostic complexity

David A. Williams, T. Walsh, M. King, 2015, Haematologica.

Iron and Erythropoiesis

N. Andrews, M. Fleming, 1999 .

ERDAFITINIB in locally advanced or metastatic urothelial carcinoma (mUC): Long-term outcomes in BLC2001.

R. Huddart, M. Fleming, B. Mellado, 2020 .

QTLs for murine red blood cell parameters in LG/J and SM/J F2 and advanced intercross lines

M. Fleming, R. Cheng, A. Palmer, 2012, Mammalian Genome.

Bone Marrow Morphology Associated With Germline RUNX1 Mutations in Patients With Familial Platelet Disorder With Associated Myeloid Malignancy

M. Fleming, A. Cantor, A. Geddis, 2019, Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.

Splenic pathology in myelodysplasia: a report of 13 cases with clinical correlation.

M. Fleming, D. Dorfman, N. Bartlett, 1998, The American journal of surgical pathology.

Molecular characterization of the acyl-coenzyme A:isopenicillin N acyltransferase gene (penDE) from Penicillium chrysogenum and Aspergillus nidulans and activity of recombinant enzyme in Escherichia coli

M. Fleming, P. Skatrud, M. Tobin, 1990, Journal of bacteriology.

Pim-1 Ligand-bound Structures Reveal the Mechanism of Serine/Threonine Kinase Inhibition by LY294002*

M. Fleming, L. Swenson, O. Futer, 2005, Journal of Biological Chemistry.

Immortalization and transformation of primary human airway epithelial cells by gene transfer

W. Hahn, R. Weinberg, M. Fleming, 2002, Oncogene.

Marjolin's ulcer: a review and reevaluation of a difficult problem.

M. Fleming, J. Hunt, G. Purdue, 1990, The Journal of burn care & rehabilitation.

Erdafitinib in Locally Advanced or Metastatic Urothelial Carcinoma.

R. Huddart, M. Fleming, B. Mellado, 2019, The New England journal of medicine.

Myelopoiesis in the zebrafish, Danio rerio.

B. Paw, L. Zon, A. Look, 2001, Blood.

Recurrent BRAF mutations in Langerhans cell histiocytosis.

W. Hahn, M. Meyerson, L. Garraway, 2010, Blood.

Loss of the acyl-CoA binding protein (Acbp) results in fatty acid metabolism abnormalities in mouse hair and skin.

M. Fleming, D. Moody, Lance Lee, 2007, The Journal of investigative dermatology.

Male infertility and thiamine-dependent erythroid hypoplasia in mice lacking thiamine transporter Slc19a2.

M. Fleming, E. Neufeld, Y. Fujiwara, 2003, Molecular genetics and metabolism.

Telomerase contributes to tumorigenesis by a telomere length-independent mechanism

Robert A. Weinberg, William C. Hahn, Mark Fleming, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Iron Deficiency Anemia Associated with an Error of Iron Metabolism in Two Siblings: A Thirty Year Follow Up.

N. Andrews, M. Fleming, D. Nathan, 1996, Hematology.

Combination therapy with a Tmprss6 RNAi-therapeutic and the oral iron chelator deferiprone additively diminishes secondary iron overload in a mouse model of β-thalassemia intermedia

M. Fleming, T. Racie, K. Fitzgerald, 2015, American journal of hematology.

Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease.

M. Loda, N. Andrews, M. Fleming, 2002, Blood.

Low Iron Promotes Megakaryocytic Commitment of Megakaryocytic-Erythroid Progenitors in Humans and Mice.

M. Fleming, K. Finberg, T. Tebaldi, 2018, Blood.

A novel syndrome of congenital sideroblastic anemia, B-cell immunodeficiency, periodic fevers, and developmental delay (SIFD).

M. Fleming, P. Chakraborty, R. Klaassen, 2013, Blood.

Mutations in TRNT1 cause congenital sideroblastic anemia with immunodeficiency, fevers, and developmental delay (SIFD).

Erin K. Kennedy, M. Fleming, Ashley Lau, 2014, Blood.

Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome

Nicholas D. Camarda, S. Carter, M. Norkin, 2021, Nature Communications.

Mutations in signal recognition particle SRP54 cause syndromic neutropenia with Shwachman-Diamond–like features

Magalie S Leduc, M. Konantz, C. Lengerke, 2017, The Journal of clinical investigation.

Heme‐regulated eIF2α kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency

S. Orkin, M. Fleming, Y. Fujiwara, 2001, The EMBO journal.

Heme-regulated eIF2α kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and β-thalassemia

M. Fleming, Jane-Jane Chen, A. Han, 2005 .

Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene

N. Andrews, M. Fleming, W. Dietrich, 1997, Nature genetics.

Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts.

H. Lodish, M. Fleming, M. Socolovsky, 2001, Blood.

A Murine Model of Chronic Lymphocytic Leukemia Based on B Cell-Restricted Expression of Sf3b1 Mutation and Atm Deletion.

Angela N. Brooks, Emanuela M. Ghia, D. Neuberg, 2019, Cancer cell.

The genomic landscape of pediatric Ewing sarcoma.

A. McKenna, A. Sivachenko, K. Cibulskis, 2014, Cancer discovery.

The Human-Specific BOLA2 Duplication Modifies Iron Homeostasis and Anemia Predisposition in Chromosome 16p11.2 Autism Individuals.

E. Eichler, J. Chrast, A. Reymond, 2019, American journal of human genetics.

Regulation of progenitor cell proliferation and granulocyte function by microRNA-223

O. Kirak, M. Fleming, F. Camargo, 2008, Nature.

Mitochondrial heme: an exit strategy at last.

M. Fleming, I. Hamza, 2012, The Journal of clinical investigation.

Physiologic Expression of Sf3b1(K700E) Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation.

Michelle C. Chen, B. Ebert, M. Fleming, 2016, Cancer cell.

Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5.

S. Orkin, M. Fleming, C. Roberts, 2002, Cancer cell.

The human-specific BOLA2 duplication modifies iron homeostasis and anemia predisposition in chromosome 16p11.2 autism patients

E. Eichler, J. Chrast, A. Reymond, 2019, bioRxiv.

Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

Fatima Al-Shahrour, Rudolf Jaenisch, Stefan Fröhling, 2010, Nature Medicine.

Primary Ciliary Dyskinesia in Mice Lacking the Novel Ciliary Protein Pcdp1

G. Pinkus, M. Fleming, T. Wyatt, 2007, Molecular and Cellular Biology.

Immunosurveillance and survivin-specific T-cell immunity in children with high-risk neuroblastoma.

G. Pinkus, M. Fleming, J. Maris, 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia.

M. Fleming, P. Taylor, Juan Du, 2010, Blood.

Oncogenic Kras-induced leukemogeneis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformation.

H. Lodish, M. Fleming, K. Young, 2009, Blood.

High-throughput tyrosine kinase activity profiling identifies FAK as a candidate therapeutic target in Ewing sarcoma.

M. Rivera, M. Fleming, B. Crompton, 2013, Cancer research.

Loss of SPEF2 Function in Mice Results in Spermatogenesis Defects and Primary Ciliary Dyskinesia1

M. Fleming, N. Kotaja, T. Wyatt, 2011, Biology of reproduction.

The Steap proteins are metalloreductases.

M. Fleming, A. Mcdonald, D. Campagna, 2006, Blood.

The spleen as a diagnostic specimen

M. Fleming, R. Vonderheide, M. Kraus, 2001, Cancer.

The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis.

J. Kutok, M. Fleming, E. Greer, 2006, Human molecular genetics.

Pathogenesis of Langerhans cell histiocytosis.

M. Fleming, B. Rollins, G. Badalian-Very, 2013, Annual review of pathology.

Defective apoptosis and B‐cell lymphomas in mice with p53 point mutation at Ser 23

T. Jacks, M. Fleming, R. Bronson, 2004, The EMBO journal.

Design and validation of a high-throughput matrix-assisted laser desorption ionization time-of-flight mass spectrometry method for quantification of hepcidin in human plasma.

Hanno Steen, Marc Kirchner, Leslie A Kalish, 2011, Analytical chemistry.

The regulation of hepcidin and its effects on systemic and cellular iron metabolism.

M. Fleming, 2008, Hematology. American Society of Hematology. Education Program.

NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms

M. Fleming, J. Harper, Mark P. Jedrychowski, 2019, Haematologica.

The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption.

M. Hentze, M. Fleming, C. Kendziorski, 2013, Cell metabolism.

Pathology of the Liver in Familial Hemophagocytic Lymphohistiocytosis

G. Pinkus, M. Fleming, K. Nichols, 2010, The American journal of surgical pathology.

anemia: implications for the anemia of chronic disease Inappropriate expression of hepcidin is associated with iron refractory

M. Loda, N. Andrews, M. Fleming, 2013 .

The Crystal Structure of Six-transmembrane Epithelial Antigen of the Prostate 4 (Steap4), a Ferri/Cuprireductase, Suggests a Novel Interdomain Flavin-binding Site*

M. Fleming, G. Gauss, A. Sendamarai, 2013, The Journal of Biological Chemistry.

PROOF 302: A randomized, double-blind, placebo-controlled, phase III trial of infigratinib as adjuvant therapy in patients with invasive urothelial carcinoma harboring susceptible FGFR3 alterations.

M. Fleming, G. Sonpavde, C. Andresen, 2020 .

Recurrent heteroplasmy for the MT-ATP6 p.Ser148Asn (m.8969G>A) mutation in patients with syndromic congenital sideroblastic anemia of variable clinical severity

M. Fleming, V. Rodriguez, M. Heeney, 2018, Haematologica.

Hscb, a Mitochondrial Iron-Sulfur Cluster Assembly Co-Chaperone, Is a Novel Candidate Gene for Congenital Sideroblastic Anemia

B. Paw, M. Fleming, J. Boudreaux, 2017 .

LARS2 Variants Associated with Hydrops, Lactic Acidosis, Sideroblastic Anemia, and Multisystem Failure.

M. Fleming, C. Sue, J. Christodoulou, 2015, JIMD reports.

X‐linked sideroblastic anemia due to ALAS2 intron 1 enhancer element GATA‐binding site mutations

M. Fleming, D. Swinkels, C. Niemeyer, 2014, American journal of hematology.

Murine mutants in the study of systemic iron metabolism and its disorders: an update on recent advances.

M. Fleming, T. Bartnikas, P. Schmidt, 2012, Biochimica et biophysica acta.

Modulation of hepcidin as therapy for primary and secondary iron overload disorders: preclinical models and approaches.

M. Fleming, P. Schmidt, 2014, Hematology/oncology clinics of North America.

Pearson marrow pancreas syndrome in patients suspected to have Diamond-Blackfan anemia.

M. Fleming, Suneet Agarwal, D. Yuan, 2014, Blood.

RED CELLS , IRON , AND ERYTHROPOIESIS Pearson marrow pancreas syndrome in patients suspected to have Diamond-Blackfan anemia

M. Fleming, Suneet Agarwal, D. Yuan, 2014 .

Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors

C. Walsh, M. Fleming, M. Harris, 2010, Journal of Cell Science.

Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors

C. Walsh, M. Fleming, M. Harris, 2010, Development.

UBE2O remodels the proteome during terminal erythroid differentiation

M. Justice, S. Gygi, M. Fleming, 2017, Science.

Identification and characterization of a novel murine allele of Tmprss6

M. Justice, M. Fleming, K. Bloch, 2013, Haematologica.

HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis.

M. Fleming, Xiaojing Yuan, I. Hamza, 2013, Cell metabolism.

A competitive enzyme-linked immunosorbent assay specific for murine hepcidin-1: correlation with hepatic mRNA expression in established and novel models of dysregulated iron homeostasis

M. Fleming, T. Ganz, E. Nemeth, 2015, Haematologica.

Pseudouridine synthase 1 deficient mice, a model for Mitochondrial Myopathy with Sideroblastic Anemia, exhibit muscle morphology and physiology alterations

Joshua E Mangum, M. Fleming, H. Lidov, 2016, Scientific Reports.

The Crystal Structure of Six Transmembrane Antigen of the Prostate 4 ( Steap 4 ) , a Ferri / Cuprireductase , Suggests a Novel Inter-Domain Flavin Binding Site

M. Fleming, G. Gauss, A. Sendamarai, 2013 .

Mutant Splicing Factor 3b Subunit 1 (SF3B1) Causes Dysregulated Erythropoiesis and a Stem Cell Disadvantage

Michelle C. Chen, B. Ebert, M. Fleming, 2014 .

RNAi‐mediated reduction of hepatic Tmprss6 diminishes anemia and secondary iron overload in a splenectomized mouse model of β‐thalassemia intermedia

M. Fleming, T. Racie, G. Visner, 2018, American journal of hematology.

High-throughput matrix-assisted laser desorption ionization-time-of-flight mass spectrometry method for quantification of hepcidin in human urine.

M. Fleming, H. Steen, C. Menzel, 2010, Analytical chemistry.

The G185R mutation disrupts function of the iron transporter Nramp2.

N. Andrews, M. Fleming, J. Fleming, 1998, Blood.

The phenotypic spectrum of germline YARS2 variants: from isolated sideroblastic anemia to mitochondrial myopathy, lactic acidosis and sideroblastic anemia 2

L. Arenillas, M. Fleming, D. Swinkels, 2018, Haematologica.

The phenotypic spectrum of germline YARS2 variants: from isolated sideroblastic anemia to mitochondrial myopathy, lactic acidosis and sideroblastic anemia 2

L. Arenillas, M. Fleming, D. Swinkels, 2018, Haematologica.

A recurring mutation in the respiratory complex 1 protein NDUFB11 is responsible for a novel form of X-linked sideroblastic anemia.

B. Paw, M. Fleming, C. Niemeyer, 2016, Blood.

immunodeficiency, periodic fevers, and developmental delay (SIFD) A novel syndrome of congenital sideroblastic anemia, B-cell

M. Fleming, P. Chakraborty, R. Klaassen, 2013 .

Emi1 Maintains Genomic Integrity during Zebrafish Embryogenesis and Cooperates with p53 in Tumor Suppression

Charles Lee, J. Downing, D. Neuberg, 2009, Molecular and Cellular Biology.

Maternal Iron Deficiency Modulates Placental Transcriptome and Proteome in Mid-Gestation of Mouse Pregnancy.

M. Fleming, J. Paulo, D. Finley, 2021, The Journal of nutrition.

Indolent T-lymphoblastic Proliferation With Disseminated Multinodal Involvement and Partial CD33 Expression

R. Warnke, Y. Natkunam, M. Fleming, 2014, The American journal of surgical pathology.

The ins and outs of erythroid heme transport

M. Fleming, Chang Cao, 2015, Haematologica.

AKT induces erythroid-cell maturation of JAK2-deficient fetal liver progenitor cells and is required for Epo regulation of erythroid-cell differentiation.

H. Lodish, M. Fleming, B. Luo, 2006, Blood.

Sideroblastic Anemias: Molecular Basis, Pathophysiology, and Clinical Aspects

M. Fleming, S. Bottomley, 2013 .

genetic iron overload disorders Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with

M. Fleming, P. Gros, L. Montross, 2013 .

Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders.

N. Andrews, M. Fleming, P. Gros, 2001, Blood.

Screen for alterations of iron related parameters in N-ethyl-N-nitrosourea-treated mice identified mutant lines with increased plasma ferritin levels

H. Fuchs, E. Wolf, M. Muckenthaler, 2015, BioMetals.

A synonymous coding variant that alters ALAS2 splicing and causes X‐linked sideroblastic anemia

M. Fleming, J. Boudreaux, Shira Rockowitz, 2021, Pediatric blood & cancer.

in murine spherocytosis Evidence for a protective role of the Gardos channel against hemolysis

M. Fleming, C. Brugnara, N. Mohandas, 2013 .

T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation.

L. Zon, R. White, D. Neuberg, 2010, Cancer cell.

Mitochondrial Atpif1 Regulates Heme Synthesis in Developing Erythroblasts

B. Paw, B. Ebert, M. Fleming, 2011 .

Evidence in the UK Biobank for the underdiagnosis of erythropoietic protoporphyria

Xihong Lin, D. Chasman, Y. Feng, 2020, Genetics in Medicine.

The Nramp2/DMT1 iron transporter is induced in the duodenum of microcytic anemiamkmice but is not properly targeted to the intestinal brush border

N. Andrews, M. Fleming, P. Gros, 2000 .

Response: What's in a name?

M. Fleming, E. Neufeld, A. Dvorak, 2007 .

The developmental stage of the hematopoietic niche regulates lineage in MLL-rearranged leukemia

Patricia Sousa, G. Daley, M. Fleming, 2019, The Journal of experimental medicine.

919TiPPembrolizumab ± chemotherapy versus chemotherapy in advanced urothelial cancer: Phase 3 KEYNOTE-361 trial

M. Fleming, T. Powles, J. Gschwend, 2017 .

Second Round Robin for plasma hepcidin methods : First steps toward harmonization

M. Muckenthaler, M. Fleming, D. Ward, 2012 .

Assessment of SBDS Expression Patterns in Human Marrow Hematopoietic and Stromal Cells by Immunohistochemistry and Its Use as a Diagnostic Screen for Schwachman-Diamond Syndrome

M. Fleming, M. Harris, A. Shimamura, 2008 .

SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1

M. Fleming, M. Haigis, P. Schmidt, 2014, Oncogene.

Radioactive seed localization for excision of non-palpable in-transit metastatic melanoma

M. Fleming, B. Pockaj, R. Gray, 2015, Radiology Case Reports.

Potential biomarkers of bortezomib activity in mantle cell lymphoma from the phase 2 PINNACLE trial

G. Mulligan, R. Fisher, M. Fleming, 2010, Leukemia & lymphoma.

Commentary on: ferrokinetics in the syndrome of familial hypoferremic microcytic anemia with iron malabsorption.

N. Andrews, M. Fleming, 1999, Journal of pediatric hematology/oncology.

The role of nuclear receptor co-activator 4 in erythropoiesis (Reply to Nai et al.)

M. Fleming, J. Harper, J. Mancias, 2019, Haematologica.

MEDI3726, a prostate-specific membrane antigen (PSMA)-targeted antibody-drug conjugate (ADC) in mCRPC after failure of abiraterone or enzalutamide.

M. Fleming, D. Petrylak, R. Cathomas, 2020 .

A phase II trial of neoadjuvant dasatinib (Neo-D) in muscle-invasive urothelial carcinoma of the bladder (miUCB): Hoosier Oncology Group GU07-122 trial.

M. Fleming, G. Sonpavde, M. Galsky, 2012 .

GATA2 Mutations In Pediatric Myelodysplastic Syndromes and Bone Marrow Failure

David A. Williams, M. Loh, M. Fleming, 2013 .

Chasing a moving target: Detection of mitochondrial heteroplasmy for clinical diagnostics

M. Fleming, Johnf . Thompson, Christopher R. Gault, 2017, bioRxiv.

The Clinical and Genetic Spectrum of TMPRSS6 Mutations Leading to Inappropriate Hepcidin Expression and Iron Refractory Iron Deficiency Anemia (IRIDA).

M. Fleming, M. Heeney, M. Westerman, 2009 .

Phase Ib/II neoadjuvant (N-) pembrolizumab (P) and chemotherapy for locally advanced urothelial cancer (laUC): Final results from the cisplatin (C)- eligible cohort of HCRN GU14-188.

M. Fleming, J. Picus, P. Fu, 2020 .

Mutations in the serum/glucocorticoid regulated kinase 3 (Sgk3) are responsible for the mouse fuzzy (fz) hair phenotype.

M. Fleming, D. Campagna, B. Antiochos, 2008, The Journal of investigative dermatology.

Isolation and characterization of abaecin, a major antibacterial response peptide in the honeybee (Apis mellifera).

M. Fleming, P. Tempst, C. Ampe, 1990, European journal of biochemistry.

Dominant negative mutants of transcription factor mXBP (CRE-BP1, ATF-2).

M. Fleming, L. Glimcher, L. Ivashkiv, 1992, The New biologist.

A novel rat model of hereditary hemochromatosis due to a mutation in transferrin receptor 2.

M. Fleming, K. Markianos, T. Bartnikas, 2012, Comparative medicine.

Corrigendum: Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts

B. Paw, B. Ebert, M. Fleming, 2013, Nature.

863PPhase 2 study of pembrolizumab alone or combined with acalabrutinib in platinum-refractory metastatic urothelial carcinoma (mUC)

J. Burke, M. Fleming, M. Harrison, 2017 .

PROTEOSTASIS UBE 2 O remodels the proteome during terminal erythroid differentiation

M. Justice, S. Gygi, M. Fleming, 2017 .

Association of p53 and WAF1 expression with apoptosis in diffuse alveolar damage.

M. Fleming, W. Travis, V. Ferrans, 1996, The American journal of pathology.