A. S. Murkin

发表

Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases.

G. Evans, R. Furneaux, B. Greatrex, 2008, Journal of medicinal chemistry.

Supplemental Data Ribocation Transition State Capture and Rebound in Human Purine Nucleoside Phosphorylase

A. S. Murkin, V. Schramm, Mahmoud Ghanem, 2009 .

Ribocation transition state capture and rebound in human purine nucleoside phosphorylase.

A. S. Murkin, V. Schramm, Mahmoud Ghanem, 2009, Chemistry & biology.

The Nitro Group as a Masked Electrophile in Covalent Enzyme Inhibition.

A. S. Murkin, A. Gulick, D. Kreitler, 2018, ACS chemical biology.

A β -Fluoroamine Inhibitor of Purine Nucleoside Phosphorylase

A. S. Murkin, V. Schramm, B. Skelton, 2015 .

The NeuC Protein of Escherichia coli K1 Is a UDP N-Acetylglucosamine 2-Epimerase

A. S. Murkin, C. Rubens, D. Daines, 2004, Journal of bacteriology.

Mechanism-based inactivator of isocitrate lyases 1 and 2 from Mycobacterium tuberculosis

A. S. Murkin, P. Tyler, J. Sacchettini, 2017, Proceedings of the National Academy of Sciences.

Identification and mechanism of a bacterial hydrolyzing UDP-N-acetylglucosamine 2-epimerase.

A. S. Murkin, W. Wakarchuk, M. Tanner, 2004, Biochemistry.

Alteration of the Flexible Loop in 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase Boosts Enthalpy-Driven Inhibition by Fosmidomycin

A. S. Murkin, G. Tombline, Juan Liu, 2014, Biochemistry.

DXP reductoisomerase: reaction of the substrate in pieces reveals a catalytic role for the nonreacting phosphodianion group.

A. S. Murkin, S. A. Kholodar, 2013, Biochemistry.

The Role of Phosphate in a Multistep Enzymatic Reaction: Reactions of the Substrate and Intermediate in Pieces

A. S. Murkin, A. Gulick, S. A. Kholodar, 2015, Journal of the American Chemical Society.

Highly precise measurement of kinetic isotope effects using 1H-detected 2D [13C,1H]-HSQC NMR spectroscopy.

A. S. Murkin, T. Szyperski, A. Eletsky, 2012, Journal of the American Chemical Society.

Transition-state-guided drug design for treatment of parasitic neglected tropical diseases.

A. S. Murkin, M. Moynihan, 2014, Current medicinal chemistry.

Femtosecond dynamics coupled to chemical barrier crossing in a Born-Oppenheimer enzyme

A. S. Murkin, V. Schramm, R. G. Silva, 2011, Proceedings of the National Academy of Sciences.

Arsenate and phosphate as nucleophiles at the transition states of human purine nucleoside phosphorylase.

A. S. Murkin, V. Schramm, R. G. Silva, 2011, Biochemistry.

Third-generation immucillins: syntheses and bioactivities of acyclic immucillin inhibitors of human purine nucleoside phosphorylase.

Andrew S Murkin, G. Evans, R. Furneaux, 2009, Journal of medicinal chemistry.

Dehydroalanine-based inhibition of a peptide epimerase from spider venom.

A. S. Murkin, M. Tanner, 2002, The Journal of organic chemistry.

α-Ketol and α-iminol rearrangements in synthetic organic and biosynthetic reactions

A. S. Murkin, S. Benz, 2021, Beilstein journal of organic chemistry.

New Electrophiles and Strategies for Mechanism-Based and Targeted Covalent Inhibitor Design.

A. S. Murkin, S. Ray, 2019, Biochemistry.

Mechanism and inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase.

Andrew S Murkin, A. S. Murkin, Kathryn A Manning, 2014, Bioorganic chemistry.

Cysteine is the general base that serves in catalysis by isocitrate lyase and in mechanism-based inhibition by 3-nitropropionate.

A. S. Murkin, M. Moynihan, 2014, Biochemistry.

Covalent Adduct Formation in Methylthio-d-ribose-1-phosphate Isomerase: Reaction Intermediate or Artifact?

A. S. Murkin, Vamsee Mohan Veeramachineni, Subashi T Ubayawardhana, 2022, Biochemistry.

Identification of Three Classes of Heteroaromatic Compounds with Activity against Intracellular Trypanosoma cruzi by Chemical Library Screening

Ana Rodriguez, A. S. Murkin, F. Buckner, 2009, PLoS neglected tropical diseases.

Neighboring group participation in the transition state of human purine nucleoside phosphorylase.

A. S. Murkin, V. Schramm, S. Almo, 2007, Biochemistry.

L-Enantiomers of transition state analogue inhibitors bound to human purine nucleoside phosphorylase.

G. Evans, R. Furneaux, A. S. Murkin, 2008, Journal of the American Chemical Society.

Pre-steady-state kinetic analysis of 1-deoxy-D-xylulose-5-phosphate reductoisomerase from Mycobacterium tuberculosis reveals partially rate-limiting product release by parallel pathways.

A. S. Murkin, Juan Liu, 2012, Biochemistry.

Plasmodium falciparum Parasites Are Killed by a Transition State Analogue of Purine Nucleoside Phosphorylase in a Primate Animal Model

G. Evans, A. S. Murkin, V. Schramm, 2011, PloS one.

Phosphate activation in the ground state of purine nucleoside phosphorylase.

A. S. Murkin, V. Schramm, H. Deng, 2006, Journal of the American Chemical Society.

A beta-fluoroamine inhibitor of purine nucleoside phosphorylase.

A. S. Murkin, V. Schramm, Lei Li, 2008, Journal of medicinal chemistry.

Transition state analogue discrimination by related purine nucleoside phosphorylases.

G. Evans, R. Furneaux, A. S. Murkin, 2006, Journal of the American Chemical Society.

Inverse Solvent Isotope Effects in Enzyme-Catalyzed Reactions

A. S. Murkin, Patrick L Fernandez, 2020, Molecules.

Transition-state interactions revealed in purine nucleoside phosphorylase by binding isotope effects.

A. S. Murkin, V. Schramm, P. Tyler, 2008, Journal of the American Chemical Society.

Ribocation transition state capture and rebound in human purine nucleoside phosphorylase.

A. S. Murkin, V. Schramm, Mahmoud Ghanem, 2009, Chemistry & biology.

Immucillins in custom catalytic-site cavities.

A. S. Murkin, V. Schramm, P. Tyler, 2008, Bioorganic & medicinal chemistry letters.