C. Brotherton-Pleiss

发表

Discovery of Novel Azetidine Amides as Potent Small-Molecule STAT3 Inhibitors

C. Brotherton-Pleiss, P. Yue, Yinsong Zhu, 2020, Journal of medicinal chemistry.

Structure-based design of six novel classes of nonpeptide antagonists of the bradykinin B2 receptor.

K. Jarnagin, C. Brotherton-Pleiss, S. Bhakta, 2000, Bioorganic & medicinal chemistry letters.

Spiropiperidine CCR5 antagonists.

C. Brotherton-Pleiss, L. Setti, D. Rotstein, 2009, Bioorganic & medicinal chemistry letters.

Novel Series of Dihydropyridinone P2X7 Receptor Antagonists.

D. Cockayne, C. Brotherton-Pleiss, F. Lopez-Tapia, 2015, Journal of medicinal chemistry.

A potent seven-membered cyclic BTK (Bruton's tyrosine Kinase) chiral inhibitor conceived by structure-based drug design to lock its bioactive conformation.

S. So, C. Brotherton-Pleiss, F. Lopez-Tapia, 2019, Bioorganic & medicinal chemistry letters.

Linker Variation and Structure-Activity Relationship Analyses of Carboxylic Acid-based Small Molecule STAT3 Inhibitors.

C. Brotherton-Pleiss, P. Yue, M. Tius, 2018, ACS medicinal chemistry letters.

Novel potent azetidine-based compounds irreversibly inhibit Stat3 activation and induce antitumor response against human breast tumor growth in vivo

C. Brotherton-Pleiss, P. Yue, Yinsong Zhu, 2022, Cancer letters.

Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling.

C. Brotherton-Pleiss, M. Volgraf, Jun Chen, 2018, Journal of medicinal chemistry.

Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-benzyl derivatives with broad potency against resistant mutant viruses.

Xianfeng Lin, Taraneh Mirzadegan, Klaus Klumpp, 2010, Bioorganic & medicinal chemistry letters.

Discovery and optimization of RO-85, a novel drug-like, potent, and selective P2X3 receptor antagonist.

J. Gever, M. P. Dillon, A. Ford, 2010, Bioorganic & medicinal chemistry letters.

Linker Variation and Structure-Activity Relationship Analyses of Carboxylic Acid-based Small Molecule STAT3 Inhibitors.

C. Brotherton-Pleiss, P. Yue, M. Tius, 2018, ACS medicinal chemistry letters.

Novel Series of Dihydropyridinone P2X7 Receptor Antagonists.

D. Cockayne, C. Brotherton-Pleiss, F. Lopez-Tapia, 2015, Journal of medicinal chemistry.