P. Yue

发表

Discovery of Novel Azetidine Amides as Potent Small-Molecule STAT3 Inhibitors

C. Brotherton-Pleiss, P. Yue, Yinsong Zhu, 2020, Journal of medicinal chemistry.

GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Down-regulating Expression of GNAI2.

P. Yue, J. Turkson, R. Holcombe, 2019, Gastroenterology.

Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity.

M. Minden, P. Yue, J. Turkson, 2012, Journal of medicinal chemistry.

Ambient Air Particulate Matter Exposure and Tissue Factor Expression in Atherosclerosis

S. Rajagopalan, P. Yue, M. Lippmann, 2008 .

STAT3 and GR Cooperate to Drive Gene Expression and Growth of Basal-Like Triple-Negative Breast Cancer

R. Myers, P. Yue, J. Turkson, 2020, Cancer Research.

Human augmenter of liver regeneration is important for hepatoma cell viability and resistance to radiation-induced oxidative stress.

P. Yue, Wang-xiang Xu, Wei Li, 2009, Free radical biology & medicine.

Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer

P. Yue, J. Turkson, Ziyou Lin, 2022, Redox biology.

Coordination complex SH2 domain proteomimetics: an alternative approach to disrupting oncogenic protein-protein interactions.

P. Yue, J. Turkson, C. Gradinaru, 2010, Chemical communications.

EDAG regulates the proliferation and differentiation of hematopoietic cells and resists cell apoptosis through the activation of nuclear factor-κB

P. Yue, C. Li, Y. Zhan, 2004, Cell Death and Differentiation.

A novel nuclear Src and p300 signaling axis controls migratory and invasive behavior in pancreatic cancer

P. Yue, J. Turkson, H. Furuya, 2015, Oncotarget.

Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain.

P. Yue, J. Turkson, S. Trudel, 2011, Bioorganic & medicinal chemistry letters.

Enhanced Sensitivity of Pancreatic Cancer Cells to Concurrent Inhibition of Aberrant Signal Transducer and Activator of Transcription 3 and Epidermal Growth Factor Receptor or Src

P. Yue, J. Turkson, Soumya Jaganathan, 2010, Journal of Pharmacology and Experimental Therapeutics.

A Functional Nuclear Epidermal Growth Factor Receptor, Src and Stat3 Heteromeric Complex in Pancreatic Cancer Cells

P. Yue, J. Turkson, Q. Huo, 2011, PloS one.

Targeting STAT3 in cancer: how successful are we?

P. Yue, J. Turkson, 2009, Expert opinion on investigational drugs.

Natural product preferentially targets redox and metabolic adaptations and aberrantly active STAT3 to inhibit breast tumor growth in vivo

P. Yue, Yinsong Zhu, M. Tius, 2022, Cell Death & Disease.

Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin α-2 Expression, and Induce Antitumor Effects against Human Glioma.

J. Sarkaria, P. Yue, J. Turkson, 2015, Journal of medicinal chemistry.

Artificially induced protein-membrane anchorage with cholesterol-based recognition agents as a new therapeutic concept.

P. Yue, J. Turkson, C. Gradinaru, 2011, Angewandte Chemie.

Air Pollution Exposure Potentiates Hypertension Through Reactive Oxygen Species–Mediated Activation of Rho/ROCK

R. Brook, S. Rajagopalan, P. Yue, 2008, Arteriosclerosis, thrombosis, and vascular biology.

Identification of Purine-Scaffold Small-Molecule Inhibitors of Stat3 Activation by QSAR Studies

P. Yue, J. Turkson, Xiaolei Zhang, 2010, ACS medicinal chemistry letters.

A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3-dependent tumor processes.

P. Yue, J. Turkson, S. Fletcher, 2010, Biochemical pharmacology.

SS-4 is a highly selective small molecule inhibitor of STAT3 tyrosine phosphorylation that potently inhibits GBM tumorigenesis in vitro and in vivo.

P. Yue, J. Turkson, J. Buolamwini, 2022, Cancer letters.

Hepatocyte growth factor-induced proliferation of hepatic stem-like cells depends on activation of NF-κB

P. Yue, C. Qu, Wang-xiang Xu, 2004 .

Hyperactive EGF receptor, Jaks and Stat3 signaling promote enhanced colony-forming ability, motility and migration of cisplatin-resistant ovarian cancer cells

P. Yue, J. Turkson, Xiaolei Zhang, 2011, Oncogene.

Targeting STAT3 in cancer: how successful are we?

P. Yue, J. Turkson, 2009, Expert opinion on investigational drugs.

Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts

P. Yue, J. Turkson, Xiaolei Zhang, 2012, Proceedings of the National Academy of Sciences.

Ambient Air Pollution Exaggerates Adipose Inflammation and Insulin Resistance in a Mouse Model of Diet-Induced Obesity

Michael C. Ostrowski, R. Brook, S. Rajagopalan, 2009, Circulation.

STAT3 and GR cooperate to drive basal-like triple negative breast cancer gene expression and proliferation

R. Myers, P. Yue, J. Turkson, 2019, bioRxiv.

Targeting STAT3-VISTA axis to suppress tumor aggression and burden in acute myeloid leukemia

P. Yue, Ziyou Lin, Kai Zhu, 2023, Journal of Hematology & Oncology.

An Integrated Computational and Experimental Binding Study Identifies the DNA Binding Domain as the Putative Binding Site of Novel Pyrimidinetrione Signal Transducer and Activator of Transcription 3 (STAT3) Inhibitors

P. Yue, J. Turkson, J. Buolamwini, 2017 .

Hydroxamic Acid and Benzoic Acid-Based STAT3 Inhibitors Suppress Human Glioma and Breast Cancer Phenotypes In Vitro and In Vivo.

P. Yue, M. Tius, F. Lopez-Tapia, 2016, Cancer research.

A Resveratrol Analogue Promotes ERKMAPK–Dependent Stat3 Serine and Tyrosine Phosphorylation Alterations and Antitumor Effects In Vitro against Human Tumor Cells

P. Yue, J. Turkson, J. Pezzuto, 2015, Molecular Pharmacology.

Antagonism of the Stat3–Stat3 Protein Dimer with Salicylic Acid Based Small Molecules

Steven Fletcher, Patrick T. Gunning, P. Yue, 2011, ChemMedChem.

Disruption of Transcriptionally Active Stat3 Dimers with Non‐phosphorylated, Salicylic Acid‐Based Small Molecules: Potent in vitro and Tumor Cell Activities

P. Yue, J. Turkson, S. Fletcher, 2009, Chembiochem : a European journal of chemical biology.

Linker Variation and Structure-Activity Relationship Analyses of Carboxylic Acid-based Small Molecule STAT3 Inhibitors.

C. Brotherton-Pleiss, P. Yue, M. Tius, 2018, ACS medicinal chemistry letters.

Air pollution and cardiac remodeling: a role for RhoA/Rho-kinase.

R. Brook, S. Rajagopalan, P. Yue, 2009, American journal of physiology. Heart and circulatory physiology.

Novel potent azetidine-based compounds irreversibly inhibit Stat3 activation and induce antitumor response against human breast tumor growth in vivo

C. Brotherton-Pleiss, P. Yue, Yinsong Zhu, 2022, Cancer letters.

Design, synthesis, and in vitro characterization of novel hybrid peptidomimetic inhibitors of STAT3 protein.

P. Yue, J. Turkson, M. Sukhai, 2011, Bioorganic & medicinal chemistry.

Ambient air particulate matter exposure and tissue factor expression in atherosclerosis.

S. Rajagopalan, P. Yue, M. Lippmann, 2008, Inhalation toxicology.

SU5416 is a potent inhibitor of hepatocyte growth factor receptor (c-Met) and blocks HGF-induced invasiveness of human HepG2 hepatoma cells.

P. Yue, H. Sun, Hong Zheng, 2004, Journal of hepatology.

15α-methoxypuupehenol Induces Antitumor Effects In Vitro and In Vivo against Human Glioblastoma and Breast Cancer Models

P. Yue, J. Turkson, P. Williams, 2017, Molecular Cancer Therapeutics.

Insulin Resistance in a Mouse Model of Diet-Induced Obesity

Michael C. Ostrowski, R. Brook, S. Rajagopalan, 2009 .

15a-methoxypuupehenol Induces Antitumor Effects In Vitro and In Vivo against Human Glioblastoma and Breast Cancer Models

P. Yue, J. Turkson, P. Williams, 2017 .

Hepatocyte growth factor-induced proliferation of hepatic stem-like cells depends on activation of NF-kappaB.

P. Yue, C. Qu, Wang-xiang Xu, 2004, Journal of Hepatology.

Reprogramming of TAMs via the STAT3/CD47-SIRPα axis promotes acquired resistance to EGFR-TKIs in lung cancer.

P. Yue, W. Feng, Ziyou Lin, 2023, Cancer letters.

Disruption of Transcriptionally Active Stat3 Dimers with Non‐phosphorylated, Salicylic Acid‐Based Small Molecules: Potent in vitro and Tumor Cell Activities

P. Yue, J. Turkson, S. Fletcher, 2009, Chembiochem : a European journal of chemical biology.

Linker Variation and Structure-Activity Relationship Analyses of Carboxylic Acid-based Small Molecule STAT3 Inhibitors.

C. Brotherton-Pleiss, P. Yue, M. Tius, 2018, ACS medicinal chemistry letters.

Metabolic reprogramming driven by IGF2BP3 promotes acquired resistance to EGFR inhibitors in non-small cell lung cancer.

P. Yue, W. Feng, Guohui Wan, 2023, Cancer research.