Simoun Mikhael

Discovery of Novel Azetidine Amides as Potent Small-Molecule STAT3 Inhibitors

C. Brotherton-Pleiss, P. Yue, Yinsong Zhu, 2020, Journal of medicinal chemistry.

Chiral Graphs: Reduced Representations of Ligand Scaffolds for Stereoselective Biomolecular Recognition, Drug Design, and Enhanced Exploration of Chemical Structure Space

Simoun Mikhael, R. Abrol, 2019, ChemMedChem.

Systemic ligand-mimicking bioparticles cross the blood-brain barrier and reduce growth of intracranial triple-negative breast cancer using the human epidermal growth factor receptor 3 (HER3) to mediate both routes

Felix Alonso-Valenteen, Simoun Mikhael, C. Svendsen, 2021, bioRxiv.

HER3-targeted protein chimera forms endosomolytic capsomeres and self-assembles into stealth nucleocapsids for systemic tumor homing of RNA interference in vivo

Felix Alonso-Valenteen, Simoun Mikhael, R. Abrol, 2019, Nucleic acids research.

Novel potent azetidine-based compounds irreversibly inhibit Stat3 activation and induce antitumor response against human breast tumor growth in vivo

C. Brotherton-Pleiss, P. Yue, Yinsong Zhu, 2022, Cancer letters.