J. Turkson

发表

Discovery of Novel Azetidine Amides as Potent Small-Molecule STAT3 Inhibitors

C. Brotherton-Pleiss, P. Yue, Yinsong Zhu, 2020, Journal of medicinal chemistry.

GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Down-regulating Expression of GNAI2.

P. Yue, J. Turkson, R. Holcombe, 2019, Gastroenterology.

Stat3 Activation by Src Induces Specific Gene Regulation and Is Required for Cell Transformation

J. Turkson, R. Jove, Tammy Bowman, 1998, Molecular and Cellular Biology.

Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

L. Ellis, J. Turkson, D. Coppola, 2002, Oncogene.

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

W. Guida, J. Turkson, R. Jove, 2007, Proceedings of the National Academy of Sciences.

Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity.

M. Minden, P. Yue, J. Turkson, 2012, Journal of medicinal chemistry.

STAT proteins: novel molecular targets for cancer drug discovery

J. Turkson, R. Jove, 2000, Oncogene.

Mechanisms of Disease: insights into the emerging role of signal transducers and activators of transcription in cancer

Eric B Haura, J. Turkson, R. Jove, 2005, Nature Clinical Practice Oncology.

Molecular Approaches towards the Inhibition of the Signal Transducer and Activator of Transcription 3 (Stat3) Protein

J. Turkson, S. Fletcher, P. Gunning, 2008, ChemMedChem.

STATs in oncogenesis

Roy Garcia, J. Turkson, R. Jove, 2000, Oncogene.

Anti-proliferative ambuic acid derivatives from Hawaiian endophytic fungus Pestalotiopsis sp. FT172.

J. Turkson, S. Cao, Chunshun Li, 2017, Phytochemistry.

NF-κB inhibitors, unique γ-pyranol-γ-lactams with sulfide and sulfoxide moieties from Hawaiian plant Lycopodiella cernua derived fungus Paraphaeosphaeria neglecta FT462

Ariel M. Sarotti, J. Turkson, J. Pezzuto, 2017, Scientific Reports.

Factorial Design Based Multivariate Modeling and Optimization of Tunable Bioresponsive Arginine Grafted Poly(cystaminebis(acrylamide)-diaminohexane) Polymeric Matrix Based Nanocarriers.

J. Turkson, S. W. Kim, K. Nam, 2017, Molecular pharmaceutics.

A New N-methoxypyridone from the Co-Cultivation of Hawaiian Endophytic Fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062

Ariel M. Sarotti, J. Turkson, S. Cao, 2017, Molecules.

The RhoU/Wrch1 Rho GTPase gene is a common transcriptional target of both the gp130/STAT3 and Wnt-1 pathways.

J. Turkson, S. Dewilde, V. Poli, 2009, The Biochemical journal.

Stat3 controls lysosomal-mediated cell death in vivo

J. Turkson, C. Watson, R. Flavell, 2011, Nature Cell Biology.

Ligand-independent phosphorylation of Y869 (Y845) links mutant EGFR signaling to stat-mediated gene expression.

J. Turkson, C. Arteaga, Seungchan Yang, 2008, Experimental cell research.

Buffer-stable chitosan-polyglutamic acid hybrid nanoparticles for biomedical applications.

J. Turkson, S. Santra, Astha Malhotra, 2013, Macromolecular bioscience.

STAT3 and GR Cooperate to Drive Gene Expression and Growth of Basal-Like Triple-Negative Breast Cancer

R. Myers, P. Yue, J. Turkson, 2020, Cancer Research.

Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer

P. Yue, J. Turkson, Ziyou Lin, 2022, Redox biology.

Coordination complex SH2 domain proteomimetics: an alternative approach to disrupting oncogenic protein-protein interactions.

P. Yue, J. Turkson, C. Gradinaru, 2010, Chemical communications.

Lycopodiellactone, an unusual δ-lactone-isochromanone from a Hawaiian plant-associated fungus Paraphaeosphaeria neglecta FT462

J. Turkson, S. Cao, Chunshun Li, 2015 .

A novel nuclear Src and p300 signaling axis controls migratory and invasive behavior in pancreatic cancer

P. Yue, J. Turkson, H. Furuya, 2015, Oncotarget.

STAT3 inhibitor has potent antitumor activity in B-lineage acute lymphoblastic leukemia cells overexpressing the high mobility group A1 (HMGA1)–STAT3 pathway

J. Turkson, L. Resar, L. Xian, 2016, Leukemia & lymphoma.

Nanoparticle delivery of inhibitory signal transducer and activator of transcription 3 G-quartet oligonucleotides blocks tumor growth in HMGA1 transgenic model of T-cell leukemia

J. Turkson, L. Resar, N. Jing, 2014, Leukemia & lymphoma.

Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain.

P. Yue, J. Turkson, S. Trudel, 2011, Bioorganic & medicinal chemistry letters.

Enhanced Sensitivity of Pancreatic Cancer Cells to Concurrent Inhibition of Aberrant Signal Transducer and Activator of Transcription 3 and Epidermal Growth Factor Receptor or Src

P. Yue, J. Turkson, Soumya Jaganathan, 2010, Journal of Pharmacology and Experimental Therapeutics.

An Unusual Benzoisoquinoline-9-one Derivative and Other Related Compounds with Antiproliferative Activity from Hawaiian Endophytic Fungus Peyronellaea sp. FT431

Ariel M. Sarotti, J. Turkson, Qingsong Liu, 2019, Molecules.

Sphaerialactonam, a γ-lactam–isochromanone from the Hawaiian endophytic fungus Paraphaeosphaeria sp. FT462

Ariel M. Sarotti, J. Turkson, S. Cao, 2017 .

A Functional Nuclear Epidermal Growth Factor Receptor, Src and Stat3 Heteromeric Complex in Pancreatic Cancer Cells

P. Yue, J. Turkson, Q. Huo, 2011, PloS one.

Targeting STAT3 in cancer: how successful are we?

P. Yue, J. Turkson, 2009, Expert opinion on investigational drugs.

Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.

J. Turkson, R. Jove, A. Cantor, 2003, Cancer research.

Natural product preferentially targets redox and metabolic adaptations and aberrantly active STAT3 to inhibit breast tumor growth in vivo

P. Yue, Yinsong Zhu, M. Tius, 2022, Cell Death & Disease.

Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin α-2 Expression, and Induce Antitumor Effects against Human Glioma.

J. Sarkaria, P. Yue, J. Turkson, 2015, Journal of medicinal chemistry.

An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects.

William P. Katt, J. Turkson, R. Jove, 2007, ACS chemical biology.

Heliotropiumides A and B, new phenolamides with N-carbamoyl putrescine moiety from Heliotropium foertherianum collected in Hawaii and their biological activities.

Ariel M. Sarotti, J. Turkson, J. Pezzuto, 2017, Bioorganic & medicinal chemistry letters.

The Potent STAT3/5 Inhibitor, BP-1-102 Demonstrates Significant Anti-Tumor Activity Against Waldenström Macroglobulinemia

J. Turkson, S. Trudel, B. Page, 2011 .

Requirement for Ras/Rac1-Mediated p38 and c-Jun N-Terminal Kinase Signaling in Stat3 Transcriptional Activity Induced by the Src Oncoprotein

J. Turkson, R. Jove, Jie Wu, 1999, Molecular and Cellular Biology.

Bioactive sesquiterpene lactones and other compounds isolated from Vernonia cinerea.

J. Turkson, T. Songsak, Xingyun Chai, 2014, Fitoterapia.

Meroterpenoids with Antiproliferative Activity from a Hawaiian-Plant Associated Fungus Peyronellaea coffeae-arabicae FT238.

J. Turkson, P. Fei, L. Walker, 2016, Organic letters.

Eremophilane sesquiterpenes from Hawaiian endophytic fungus Chaetoconis sp. FT087.

J. Turkson, T. Mahmud, S. Cao, 2016, Phytochemistry.

Bromotyrosine-derived metabolites from an Indonesian marine sponge in the family Aplysinellidae (Order Verongiida).

J. Turkson, P. Williams, M. Kelly, 2016, Bioorganic & medicinal chemistry letters.

Artificially induced protein-membrane anchorage with cholesterol-based recognition agents as a new therapeutic concept.

P. Yue, J. Turkson, C. Gradinaru, 2011, Angewandte Chemie.

Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells.

J. Turkson, G. Ciliberto, R. Jove, 1999, Immunity.

Hepatitis C Virus (HCV) Constitutively Activates STAT-3 via Oxidative Stress: Role of STAT-3 in HCV Replication

A. Siddiqui, J. Turkson, T. Hassanein, 2005, Journal of Virology.

STAT3 as a target for inducing apoptosis in solid and hematological tumors

J. Turkson, K. Siddiquee, 2008, Cell Research.

A Novel Platinum Compound Inhibits Constitutive Stat3 Signaling and Induces Cell Cycle Arrest and Apoptosis of Malignant Cells*

J. Turkson, R. Jove, Shumin M. Zhang, 2005, Journal of Biological Chemistry.

Hepatitis C Virus ( HCV ) Constitutively Activates STAT3 via Oxidative Stress : Role of STAT3 in HCV Replication

A. Siddiqui, J. Turkson, T. Hassanein, 2005 .

The high-mobility group A1a/signal transducer and activator of transcription-3 axis: an achilles heel for hematopoietic malignancies?

Jeanne Kowalski, Linzhao Cheng, Takita Felder Sumter, 2008, Cancer research.

The R(h)oads to Stat3: Stat3 activation by the Rho GTPases.

J. Turkson, M. Geletu, L. Raptis, 2011, Experimental cell research.

Identification of Purine-Scaffold Small-Molecule Inhibitors of Stat3 Activation by QSAR Studies

P. Yue, J. Turkson, Xiaolei Zhang, 2010, ACS medicinal chemistry letters.

THE ROLE OF RASGRP 1 IN RAS-INDUCED HUMAN EPIDERMAL NEOPLASIA A DISSERTATION SUBMITTED TO THE GRADUATE DIVISION OF THE UNIVERSITY OF HAWAI ‘ I AT MĀNOA IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY

J. Turkson, Junfang Ji, A. Lau, 2014 .

A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3-dependent tumor processes.

P. Yue, J. Turkson, S. Fletcher, 2010, Biochemical pharmacology.

THAP5 is a DNA-binding transcriptional repressor that is regulated in melanoma cells during DNA damage-induced cell death.

J. Turkson, A. Zervos, M. Takata, 2011, Biochemical and biophysical research communications.

Phosphotyrosyl Peptides Block Stat3-mediated DNA Binding Activity, Gene Regulation, and Cell Transformation*

J. Turkson, R. Jove, A. Hamilton, 2001, The Journal of Biological Chemistry.

Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein

J. Turkson, R. Jove, A. Khaled, 2006, Molecular Cancer Therapeutics.

Sensitization of pancreatic cancer cells to radiation by cerium oxide nanoparticle-induced ROS production.

Soumen Das, Jihe Zhao, Sudipta Seal, 2013, Nanomedicine : nanotechnology, biology, and medicine.

SS-4 is a highly selective small molecule inhibitor of STAT3 tyrosine phosphorylation that potently inhibits GBM tumorigenesis in vitro and in vivo.

P. Yue, J. Turkson, J. Buolamwini, 2022, Cancer letters.

NF-κB inhibitors, unique γ-pyranol-γ-lactams with sulfide and sulfoxide moieties from Hawaiian plant Lycopodiella cernua derived fungus Paraphaeosphaeria neglecta FT462

Ariel M. Sarotti, J. Turkson, J. Pezzuto, 2017, Scientific Reports.

Cell-to-cell adhesion modulates Stat3 activity in normal and breast carcinoma cells

J. Turkson, R. Jove, B. Elliott, 2004, Oncogene.

STAT proteins as novel targets for cancer drug discovery

J. Turkson, James Turkson, 2004, Expert opinion on therapeutic targets.

Role of Tyrosine Kinase Activity of Epidermal Growth Factor Receptor in the Lysophosphatidic Acid-stimulated Mitogen-activated Protein Kinase Pathway*

J. Turkson, R. Jove, Jie Wu, 1998, The Journal of Biological Chemistry.

Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways

G. Semenza, J. Turkson, J. Cheng, 2005, Oncogene.

Drug composition cytotoxic for pancreatic cancer cells (US)

J. Turkson, 2016 .

Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells

J. Turkson, R. Jove, J. Karras, 2003, Oncogene.

Persistent Activation of Stat3 Signaling Induces Survivin Gene Expression and Confers Resistance to Apoptosis in Human Breast Cancer Cells

S. Eschrich, J. Turkson, R. Jove, 2006, Clinical Cancer Research.

Therapeutic modulators of STAT signalling for human diseases

J. Turkson, Tyvette S. Hilliard, Gabriella Miklóssy, 2013, Nature Reviews Drug Discovery.

Hyperactive EGF receptor, Jaks and Stat3 signaling promote enhanced colony-forming ability, motility and migration of cisplatin-resistant ovarian cancer cells

P. Yue, J. Turkson, Xiaolei Zhang, 2011, Oncogene.

Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression.

J. Turkson, R. Jove, Jin Hong Liu, 2001, The Journal of clinical investigation.

RasGRP1 induces autophagy and transformation-associated changes in primary human keratinocytes

J. Turkson, D. Geerts, Junfang Ji, 2020, Translational oncology.

Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity.

J. Turkson, R. Jove, Meijuan Huang, 2004, Molecular cancer therapeutics.

Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells

J. Turkson, J. Cheng, R. Jove, 2005, Proceedings of the National Academy of Sciences of the United States of America.

27-Hydroxycholesterol Impairs Plasma Membrane Lipid Raft Signaling as Evidenced by Inhibition of IL6–JAK–STAT3 Signaling in Prostate Cancer Cells

J. Turkson, S. Freedland, J. Chi, 2020, Molecular Cancer Research.

Cytoplasmic transport of Stat3 by receptor‐mediated endocytosis

J. Turkson, A. Bild, R. Jove, 2002, The EMBO journal.

Targeting STAT3 in cancer: how successful are we?

P. Yue, J. Turkson, 2009, Expert opinion on investigational drugs.

Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts

P. Yue, J. Turkson, Xiaolei Zhang, 2012, Proceedings of the National Academy of Sciences.

Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling

J. Turkson, R. Jove, W. Wharton, 2000, Oncogene.

Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine

J. Onuchic, K. Mikoshiba, N. Rothman, 2018, Cell Death & Differentiation.

Stat3 is required for full neoplastic transformation by the Simian Virus 40 large tumor antigen.

J. Turkson, R. Jove, G. Niu, 2005, Molecular biology of the cell.

Bioactive polyprenylated benzophenone derivatives from the fruits extracts of Garcinia xanthochymus.

J. Turkson, S. Laphookhieo, U. Youn, 2017, Bioorganic & medicinal chemistry letters.

STAT3 and GR cooperate to drive basal-like triple negative breast cancer gene expression and proliferation

R. Myers, P. Yue, J. Turkson, 2019, bioRxiv.

A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction

J. Turkson, P. Provero, D. Levy, 2010, Aging.

Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity.

J. Turkson, Hua Yu, R. Jove, 2004, Molecular cancer therapeutics.

Constitutively active Stat3 enhances neu-mediated migration and metastasis in mammary tumors via upregulation of Cten.

J. Turkson, P. Musiani, P. Provero, 2010, Cancer research.

A New Metabolite with a Unique 4-Pyranone-γ-Lactam-1,4-Thiazine Moiety from a Hawaiian-Plant Associated Fungus.

J. Turkson, L. Walker, Chunshun Li, 2015, Organic letters.

Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains.

William P. Katt, J. Turkson, R. Jove, 2007, Bioorganic & medicinal chemistry letters.

Staurosporine induces hydrolysis of phosphatidyl inositol 4,5‐bisphosphate in human platelets

J. Turkson, Kenneth Wong, Xue-bin Li, 1994, FEBS letters.

A Cell-permeable Stat3 SH2 Domain Mimetic Inhibits Stat3 Activation and Induces Antitumor Cell Effects in Vitro*

J. Turkson, Wei Zhao, Soumya Jaganathan, 2010, The Journal of Biological Chemistry.

An Integrated Computational and Experimental Binding Study Identifies the DNA Binding Domain as the Putative Binding Site of Novel Pyrimidinetrione Signal Transducer and Activator of Transcription 3 (STAT3) Inhibitors

P. Yue, J. Turkson, J. Buolamwini, 2017 .

Hydroxamic Acid and Benzoic Acid-Based STAT3 Inhibitors Suppress Human Glioma and Breast Cancer Phenotypes In Vitro and In Vivo.

P. Yue, M. Tius, F. Lopez-Tapia, 2016, Cancer research.

Historical Development of STAT3 Inhibitors and Early Results in Clinical Trials

J. Turkson, R. Jove, Chao-Lan Yu, 2016 .

A Resveratrol Analogue Promotes ERKMAPK–Dependent Stat3 Serine and Tyrosine Phosphorylation Alterations and Antitumor Effects In Vitro against Human Tumor Cells

P. Yue, J. Turkson, J. Pezzuto, 2015, Molecular Pharmacology.

STAT3 Activation by Type I Interferons Is Dependent on Specific Tyrosines Located in the Cytoplasmic Domain of Interferon Receptor Chain 2c

J. Turkson, R. Jove, E. Croze, 2002, The Journal of Biological Chemistry.

Activation of Stat3 in v-Src-transformed Fibroblasts Requires Cooperation of Jak1 Kinase Activity*

J. Turkson, R. Jove, A. Kraker, 2000, The Journal of Biological Chemistry.

Antagonism of the Stat3–Stat3 Protein Dimer with Salicylic Acid Based Small Molecules

Steven Fletcher, Patrick T. Gunning, P. Yue, 2011, ChemMedChem.

Disruption of Transcriptionally Active Stat3 Dimers with Non‐phosphorylated, Salicylic Acid‐Based Small Molecules: Potent in vitro and Tumor Cell Activities

P. Yue, J. Turkson, S. Fletcher, 2009, Chembiochem : a European journal of chemical biology.

Linker Variation and Structure-Activity Relationship Analyses of Carboxylic Acid-based Small Molecule STAT3 Inhibitors.

C. Brotherton-Pleiss, P. Yue, M. Tius, 2018, ACS medicinal chemistry letters.

Novel potent azetidine-based compounds irreversibly inhibit Stat3 activation and induce antitumor response against human breast tumor growth in vivo

C. Brotherton-Pleiss, P. Yue, Yinsong Zhu, 2022, Cancer letters.

Design, synthesis, and in vitro characterization of novel hybrid peptidomimetic inhibitors of STAT3 protein.

P. Yue, J. Turkson, M. Sukhai, 2011, Bioorganic & medicinal chemistry.

Targeting Protein–Protein Interactions: Suppression of Stat3 Dimerization with Rationally Designed Small‐Molecule, Nonpeptidic SH2 Domain Binders

William P. Katt, J. Turkson, S. Sebti, 2008, Chembiochem : a European journal of chemical biology.

Cancer Drug Discovery and Anticancer Drug Development

J. Turkson, James Turkson, 2017 .

An activatable multimodal/multifunctional nanoprobe for direct imaging of intracellular drug delivery.

J. Turkson, S. Fletcher, G. Walter, 2012, Biomaterials.

Verbenanone, an octahydro-5H-chromen-5-one from a Hawaiian-Plant Associated Fungus FT431.

Ariel M. Sarotti, J. Turkson, Chunshun Li, 2017, Tetrahedron letters.

The Role of Micro Financial Institutions in Ghana: The Small and Medium Enterprise Perspective

J. Turkson, K. Appiah, P. Hagan, 2009 .

Involvement of FANCD2 in Energy Metabolism via ATP5α

J. Turkson, P. Fei, Chi Ma, 2017, Scientific Reports.

Financial literacy of cocoa farmers in Ghana

J. Turkson, K. Appiah, George Osei Akoto, 2017 .

15α-methoxypuupehenol Induces Antitumor Effects In Vitro and In Vivo against Human Glioblastoma and Breast Cancer Models

P. Yue, J. Turkson, P. Williams, 2017, Molecular Cancer Therapeutics.

Cover Picture: Molecular Approaches towards the Inhibition of the Signal Transducer and Activator of Transcription 3 (Stat3) Protein (ChemMedChem 8/2008)

J. Turkson, S. Fletcher, P. Gunning, 2008 .

Involvement of FANCD2 in Energy Metabolism via ATP5α

J. Turkson, P. Fei, Chi Ma, 2017, Scientific Reports.

15a-methoxypuupehenol Induces Antitumor Effects In Vitro and In Vivo against Human Glioblastoma and Breast Cancer Models

P. Yue, J. Turkson, P. Williams, 2017 .

Small molecule inhibitors of stat 3 with anti-tumor activity 6-14-2011

W. Guida, J. Turkson, S. Sebti, 2016 .

A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction

J. Turkson, P. Provero, D. Levy, 2010, Aging.

Differential effects of Stat3 inhibition in sparse vs confluent normal and breast cancer cells.

J. Turkson, R. Jove, A. Hamilton, 2006, Cancer letters.

STAT3 inhibitor having anti-cancer activity and methods (US)

J. Turkson, R. Jove, S. Sebti, 2020 .

STAT 3 inhibitor having anti-cancer activity and methods ( US ) 12-17-2013