Justin D Dietrich

发表

Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design.

S. C. Panchal, Philip B. Cox, P. Hajduk, 2020, Journal of medicinal chemistry.

SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding.

Hongyu Zhao, Ying Wang, Zhiqin Ji, 2017, Bioorganic & medicinal chemistry letters.

Hydrophobic Pockets of HPMC Enable Extremely Short Reaction Times in Water

D. Petkova, Justin D Dietrich, W. Braje, 2020 .

A simple, cheap alternative to 'designer convertible isonitriles' expedited with microwaves

Justin D Dietrich, C. Hulme, Shashi Chappeta, 2009 .

An efficient solution phase synthesis of triazadibenzoazulenones : 'designer isonitrile free' methodology enabled by microwaves

Justin D Dietrich, C. Hulme, C. S. Griffith, 2009 .

Concise Preparation of Novel Tricyclic Chemotypes: Fused Hydantoin-benzodiazepines.

Justin D Dietrich, C. Hulme, G. Nichol, 2010, Tetrahedron letters.

Two step syntheses of fused quinoxaline-benzodiazepines and bis-benzodiazepines.

Justin D Dietrich, C. Hulme, A. Shaw, 2010, Tetrahedron letters.

Discovery of Novel Aminotetralines and Aminochromanes as Selective and Competitive Glycine Transporter 1 (GlyT1) Inhibitors.

Justin D Dietrich, A. Vasudevan, J. Sydor, 2018, Journal of medicinal chemistry.

Two step syntheses of fused quinoxaline-benzodiazepines and bis-benzodiazepines.

Justin D Dietrich, C. Hulme, A. Shaw, 2010, Tetrahedron letters.

Concise Two-Step Solution Phase Syntheses of four novel Dihydroquinazoline scaffolds.

Justin D Dietrich, C. Hulme, N. Meurice, 2010, Tetrahedron letters.

Reagent and Catalyst Capsules: A Chemical Delivery System for Reaction Screening and Parallel Synthesis.

Justin D Dietrich, W. Braje, Niginia Borlinghaus, 2020, The Journal of organic chemistry.

Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site

Justin D Dietrich, A. Petros, P. Richardson, 2022, Scientific Reports.

De Novo Design, Synthesis, and Biological Evaluation of 3,4-Disubstituted Pyrrolidine Sulfonamides as Potent and Selective Glycine Transporter 1 Competitive Inhibitors.

Justin D Dietrich, A. Vasudevan, J. Sydor, 2018, Journal of medicinal chemistry.

The Design, Synthesis, and Evaluation of Novel DFG-out Allosteric Kinase Inhibitors

Justin D Dietrich, 2008 .

Emerging molecular diversity from the intra-molecular Ugi reaction: iterative efficiency in medicinal chemistry

Justin D Dietrich, C. Hulme, 2009, Molecular Diversity.

Facile, novel two-step syntheses of benzimidazoles, bis-benzimidazoles, and bis-benzimidazole-dihydroquinoxalines

Justin D Dietrich, C. Hulme, A. Shaw, 2012, Molecular Diversity.

Applications of Isocyanides in IMCRs for the Rapid Generation of Molecular Diversity

Justin D Dietrich, C. Hulme, M. Ayaz, 2012 .

A novel route to synthesize libraries of quinoxalines via Petasis methodology in two synthetic operations.

Justin D Dietrich, C. Hulme, M. Ayaz, 2011, Tetrahedron Letters.

Privileged scaffolds in lead generation

Hongyu Zhao, Justin Dietrich, Justin D Dietrich, 2015, Expert opinion on drug discovery.

Application of a novel [3+2] cycloaddition reaction to prepare substituted imidazoles and their use in the design of potent DFG-out allosteric B-Raf inhibitors.

Justin D Dietrich, L. Hurley, Xiadong Wang, 2010, Bioorganic & medicinal chemistry.

Synthesis and biological activity of 2-aminothiazoles as novel inhibitors of PGE2 production in cells.

Justin D Dietrich, C. Hulme, E. Meuillet, 2012, Bioorganic & medicinal chemistry letters.

Synthesis and biological activity of aminophthalazines and aminopyridazines as novel inhibitors of PGE2 production in cells.

Justin D Dietrich, C. Hulme, E. Meuillet, 2013, Bioorganic & medicinal chemistry letters.

A Strategy for the Synthesis of Sulfonamides on DNA.

Justin D Dietrich, Xuanjia Peng, Hongfang Yang, 2019, Organic letters.

Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma

K. Aldape, Justin D Dietrich, C. Hulme, 2014, Science Signaling.

The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.

Jun Guo, Kenneth M Comess, Haizhong Zhu, 2017, Nature chemical biology.

ERK crosstalks with 4EBP1 to activate cyclin D1 translation during quinol-thioether-induced tuberous sclerosis renal cell carcinoma.

Justin D Dietrich, R. Nagle, T. Monks, 2011, Toxicological Sciences.

ERK Crosstalks with 4 EBP 1 to Activate Cyclin D 1 Translation during Quinol-Thioether – Induced Tuberous Sclerosis Renal Cell Carcinoma

Justin D Dietrich, R. Nagle, T. Monks, 2011 .

The design, synthesis, and evaluation of 8 hybrid DFG-out allosteric kinase inhibitors: a structural analysis of the binding interactions of Gleevec, Nexavar, and BIRB-796.

Christopher Hulme, Justin D Dietrich, C. Hulme, 2010, Bioorganic & medicinal chemistry.

Fragment-Based Discovery of an Apolipoprotein E4 (apoE4) Stabilizer.

Justin D Dietrich, A. Petros, V. Stoll, 2019, Journal of medicinal chemistry.

Synthesis of Di- and Tri-Substituted Imidazole-4-carboxylates via PBu3-Mediated [3 + 2] Cycloaddition

Justin D Dietrich, C. Hulme, A. Shaw, 2013 .

Synthesis of Di‐ and Tri‐Substituted Imidazole‐4‐carboxylates via PBu3‐Mediated [3 + 2] Cycloaddition

Justin D Dietrich, C. Hulme, A. Shaw, 2013 .

Emerging Molecular Diversity from the Intramolecular Ugi Reaction: Iterative Efficiency in Medicinal Chemistry.

Justin D Dietrich, C. Hulme, 2009 .

Facile, novel two-step syntheses of benzimidazoles, bis-benzimidazoles, and bis-benzimidazole-dihydroquinoxalines

Justin D Dietrich, C. Hulme, A. Shaw, 2012, Molecular Diversity.

2-Propyl 3,3-dibromo-2-hydroxypyrrolidine-1-carboxylate

Justin D Dietrich, C. Hulme, Zhigang Xu, 2010, Acta crystallographica. Section E, Structure reports online.

The Design, Synthesis, and Evaluation of Novel DFG-out Allosteric Kinase Inhibitors

Justin D Dietrich, 2008 .

ERK crosstalks with 4EBP1 to activate cyclin D1 translation during quinol-thioether-induced tuberous sclerosis renal cell carcinoma.

Justin D Dietrich, R. Nagle, T. Monks, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors.

Ana L. Aguirre, A. Bogdan, Justin D Dietrich, 2018, Bioorganic & medicinal chemistry letters.

The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.

Mikkel A. Algire, Justin D Dietrich, A. Petros, 2017, Nature chemical biology.

SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding.

Mikkel A. Algire, Justin D Dietrich, P. Richardson, 2017, Bioorganic & medicinal chemistry letters.