P. Richardson

发表

Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design.

S. C. Panchal, Philip B. Cox, P. Hajduk, 2020, Journal of medicinal chemistry.

Discovery and Design of Novel HSP90 Inhibitors Using Multiple Fragment‐based Design Strategies

Jean M. Severin, P. Hajduk, J. R. Huth, 2007, Chemical biology & drug design.

A chemical biology toolbox to study protein methyltransferases and epigenetic signaling

Jian Jin, Matthieu Schapira, Jennifer A. Ward, 2019, Nature Communications.

Tumor-conditional anti-CTLA4 uncouples antitumor efficacy from immunotherapy-related toxicity

D. M. Simons, P. Richardson, J. Mankovich, 2018, The Journal of clinical investigation.

NRF2 activator A-1396076 ameliorates inflammation in autoimmune disease models by inhibiting antigen dependent T cell activation

Christian Goess, P. Richardson, D. Donnelly-roberts, 2020, Journal of translational autoimmunity.

A fluorescence polarization-based assay for peptidyl prolyl cis/trans isomerase cyclophilin A.

P. Richardson, Donald D. Johnson, W. Kati, 2006, Analytical biochemistry.

Interactions of two monoclonal antibodies with BNP: high resolution epitope mapping using fluorescence correlation spectroscopy.

P. Richardson, Huaiqin Wu, Q. Ruan, 2006, Biochemistry.

Functional comparison of recombinant acidic mammalian chitinase with enzyme from murine bronchoalveolar lavage.

P. Richardson, J. Mankovich, A. Cherniack, 2011, Protein expression and purification.

Microarrayed Compound Screening (μARCS) to Identify Activators and Inhibitors of AMP-Activated Protein Kinase

P. Richardson, D. Egan, J. Kofron, 2004, Journal of biomolecular screening.

Glycan‐Mediated, Ligand‐Controlled Click Chemistry for Drug‐Target Identification

P. Richardson, A. Vasudevan, D. Davidson, 2016, Chembiochem : a European journal of chemical biology.

Species specificity of amidine-based urokinase inhibitors.

P. Richardson, V. Giranda, S. Dorwin, 2001, Biochemistry.

Tethered oligonucleotide probes. A strategy for the recognition of structured RNA

P. Richardson, A. Schepartz, 1991 .

Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site

Justin D Dietrich, A. Petros, P. Richardson, 2022, Scientific Reports.

Longer wavelength fluorescence resonance energy transfer depsipeptide substrates for hepatitis C virus NS3 protease.

P. Richardson, U. Warrior, J. Randolph, 2007, Analytical biochemistry.

Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors

C. Tse, K. Longenecker, P. Richardson, 2017, Molecular Cancer Therapeutics.

High-level bacterial expression and purification of human SirT2 protein for NMR studies.

P. Hajduk, D. Song, P. Richardson, 2006, Protein expression and purification.

Fluorescence assay of SIRT protein deacetylases using an acetylated peptide substrate and a secondary trypsin reaction.

K. Glaser, A. Gunasekera, P. Richardson, 2004, Analytical biochemistry.

Corrigendum to “Fluorescence assay of SIRT protein deacetylases using an acetylated peptide substrate and a secondary trypsin reaction” [Anal. Biochem. 332 (2004) 90–99]

K. Glaser, A. Gunasekera, P. Richardson, 2006 .

Quantitative ligand and receptor binding studies reveal the mechanism of interleukin-36 (IL-36) pathway activation

P. Richardson, Chaohong Sun, E. DiGiammarino, 2017, The Journal of Biological Chemistry.

Hepatitis C NS3 protease inhibition by peptidyl-alpha-ketoamide inhibitors: kinetic mechanism and structure.

P. Richardson, V. Stoll, A. Molla, 2004, Archives of biochemistry and biophysics.

Cell-Surface Receptor-Ligand Interaction Analysis with Homogeneous Time-Resolved FRET and Metabolic Glycan Engineering: Application to Transmembrane and GPI-Anchored Receptors.

P. Richardson, A. Vasudevan, V. Scott, 2017, Journal of the American Chemical Society.

SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT).

Ana L. Aguirre, Mikkel A. Algire, C. Tse, 2017, Bioorganic & medicinal chemistry letters.

Methods to measure the intracellular concentration of unlabeled compounds within cultured cells using liquid chromatography/tandem mass spectrometry.

P. Richardson, W. Kati, C. Chen, 2008, Analytical biochemistry.

A uniquely modified RNA: Introduction of a single RNA cleavage agent into the M1 ribozyme

Richard D. Smith, P. Richardson, A. Schepartz, 1994 .

A high throughput fluorescent assay for measuring the activity of fatty acid amide hydrolase

Jean M. Severin, P. Richardson, L. Traphagen, 2007, Journal of Neuroscience Methods.

Kinetic and thermodynamic analysis of RNA binding by tethered oligonucleotide probes : alternative structures and conformational changes

P. Richardson, A. Schepartz, S. Cload, 1993 .

Indole amide hydroxamic acids as potent inhibitors of histone deacetylases.

Yan Guo, Jun Guo, Yujia Dai, 2003, Bioorganic & medicinal chemistry letters.

Structural characterization of a soluble amyloid beta-peptide oligomer.

P. Hajduk, P. Richardson, Liping Yu, 2009, Biochemistry.

Target Identification of Compounds from a Cell Viability Phenotypic Screen Using a Bead/Lysate-Based Affinity Capture Platform

P. Richardson, Hua Tang, S. Warder, 2016, Journal of biomolecular screening.

Crystal structure and thermodynamic analysis of diagnostic mAb 106.3 complexed with BNP 5‐13 (C10A)

K. Longenecker, P. Richardson, Q. Ruan, 2009, Proteins.

Development of inverse electron demand Diels-Alder ligation and TR-FRET assays for the determination of ligand-protein target occupancy in live cells.

P. Richardson, A. Vasudevan, Aleksandra Baranczak, 2017, MedChemComm.

Emerging Approaches for the Identification of Protein Targets of Small Molecules - A Practitioners' Perspective.

Anil Vasudevan, Kenneth M Comess, Henning Stöckmann, 2018, Journal of medicinal chemistry.

Controlling cellular distribution of drugs with permeability modifying moieties.

P. Richardson, A. Vasudevan, J. Wilsbacher, 2019, MedChemComm.

Discovering novel ligands for macromolecules using X-ray crystallographic screening

Vicki L. Nienaber, Paul L. Richardson, Jonathan Greer, 2000, Nature Biotechnology.

Small Molecule IL-36 gamma Antagonist as a Novel Therapeutic Approach for Plaque Psoriasis.

P. Richardson, Chaohong Sun, R. Henry, 2019 .

Small Molecule IL-36γ Antagonist as a Novel Therapeutic Approach for Plaque Psoriasis

P. Richardson, Chaohong Sun, R. Henry, 2019, Scientific Reports.

A chemical biology toolbox to study protein methyltransferases and epigenetic signaling

Jennifer A. Ward, P. Richardson, C. Arrowsmith, 2018, bioRxiv.

Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS

P. Hajduk, D. Song, P. Richardson, 2007, Proceedings of the National Academy of Sciences.

Non-peptide entry inhibitors of HIV-1 that target the gp41 coiled coil pocket.

Kent D. Stewart, Vincent S. Stoll, Jeffrey R. Huth, 2010, Bioorganic & medicinal chemistry letters.

Alpha-keto amides as inhibitors of histone deacetylase.

K. Glaser, S. Davidsen, P. Richardson, 2003, Bioorganic & Medicinal Chemistry Letters.

Pseudosubstrate peptides inhibit Akt and induce cell growth inhibition.

P. Richardson, T. Holzman, X. Liu, 2004, Biochemistry.

Efficient Synthesis of Disulfide Bridge Containing Peptides: Melanin Concentrating Hormone (MCH) and Brain Natriuretic Peptide (BNP)

P. Richardson, B. Dayton, S. Brodjian, 2006 .

α-Keto amides as inhibitors of histone deacetylase

Paul L. Richardson, Zhiqin Ji, Jun Guo, 2003 .

SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding.

Hongyu Zhao, Ying Wang, Zhiqin Ji, 2017, Bioorganic & medicinal chemistry letters.

Discovery, identification, and characterization of candidate pharmacodynamic markers of methionine aminopeptidase-2 inhibition.

S. Davidsen, P. Richardson, Qian Zhang, 2008, Journal of proteome research.

Emerging Approaches for the Identification of Protein Targets of Small Molecules - A Practitioners' Perspective.

P. Richardson, K. Comess, A. Vasudevan, 2018, Journal of Medicinal Chemistry.

Design and characterization of an engineered gp41 protein from human immunodeficiency virus-1 as a tool for drug discovery

Kevin Harris, Kent D. Stewart, Kevin Steffy, 2007, J. Comput. Aided Mol. Des..

SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding.

Mikkel A. Algire, Justin D Dietrich, P. Richardson, 2017, Bioorganic & medicinal chemistry letters.