K. Comess

发表

Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design.

S. C. Panchal, Philip B. Cox, P. Hajduk, 2020, Journal of medicinal chemistry.

An Ultraefficient Affinity-Based High-Throughout Screening Process: Application to Bacterial Cell Wall Biosynthesis Enzyme MurF

K. Comess, Hua Tang, D. Burns, 2006, Journal of biomolecular screening.

Discovery of a novel small molecule binding site of human survivin.

Jun Chen, Saul H Rosenberg, Kenneth M Comess, 2007, Bioorganic & medicinal chemistry letters.

Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases.

Hua Tang, Bo Liu, Gang Liu, 2011, ACS chemical biology.

NMR-driven discovery of benzoylanthranilic acid inhibitors of far upstream element binding protein binding to the human oncogene c-myc promoter.

G. Clore, P. Hajduk, J. R. Huth, 2004, Journal of medicinal chemistry.

Construction of a synthetic gene for the metalloregulatory protein MerR and analysis of regionally mutated proteins for transcriptional regulation.

K. Comess, C. Walsh, L. Shewchuk, 1994, Biochemistry.

Replication inhibition and translesion synthesis on templates containing site-specifically placed cis-diamminedichloroplatinum(II) DNA adducts.

K. Comess, S. Lippard, J. Essigmann, 1992, Biochemistry.

Discovery of novel inhibitors of Bcl-xL using multiple high-throughput screening platforms.

J. R. Huth, A. Petros, K. Comess, 2004, Analytical biochemistry.

Molecular Aspects of Platinum-DNA Interactions

K. Comess, S. Lippard, 1993 .

Complex Gel Permeation Assays for Screening Combinatorial Libraries

K. Comess, U. Warrior, D. Burns, 2001, Journal of biomolecular screening.

A specific inhibitor of PfCDPK4 blocks malaria transmission: chemical-genetic validation.

Dustin J Maly, X. Su, K. Comess, 2014, The Journal of infectious diseases.

Fast atom bombardment and high performance tandem mass spectrometry of platinum(II) oligodeoxyribonucleotide fragments

K. Comess, S. Lippard, C. Costello, 1992 .

Speci fi c Inhibitor of Pf CDPK 4 Blocks Malaria Transmission : Chemical-genetic Validation

X. Su, K. Comess, W. V. Voorhis, 2013 .

Quantitative, Real-Time Measurements of Intracellular Target Engagement Using Energy Transfer.

K. Comess, K. Wood, R. Hurst, 2018, Methods in molecular biology.

Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties.

Scott A. Erickson, K. Comess, A. Vasudevan, 2006, Bioorganic & medicinal chemistry letters.

The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity.

Mikkel A. Algire, K. Comess, Chaohong Sun, 2017, Nature chemical biology.

A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding

K. Comess, G. Shaw, D. Cumming, 1995, Cell.

Development of a High-Content Screening Assay Panel to Accelerate Mechanism of Action Studies for Oncology Research

Kenneth M Comess, P. Hajduk, K. Comess, 2012, Journal of biomolecular screening.

Identification and characterization of a novel linkage isomerization in the reaction of trans-diamminedichloroplatinum(II) with 5'-d(TCTACGCGTTCT).

K. Comess, S. Lippard, C. Costello, 1990, Biochemistry.

The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.

Jun Guo, Kenneth M Comess, Haizhong Zhu, 2017, Nature chemical biology.

Kinase Drug Discovery by Affinity Selection/Mass Spectrometry (ASMS): Application to DNA Damage Checkpoint Kinase Chk1

Hua Tang, Mark E Schurdak, Michael Coen, 2006, Journal of biomolecular screening.

From Bacterial Genomes to Novel Antibacterial Agents: Discovery, Characterization, and Antibacterial Activity of Compounds that Bind to HI0065 (YjeE) from Haemophilus influenzae

P. Hajduk, K. Comess, Liping Yu, 2007, Chemical biology & drug design.

Isolated P-selectin Glycoprotein Ligand-1 Dynamic Adhesion to P- and E-selectin

K. Comess, F. Luscinskas, D. J. Goetz, 1997, The Journal of cell biology.

Emerging Approaches for the Identification of Protein Targets of Small Molecules - A Practitioners' Perspective.

Anil Vasudevan, Kenneth M Comess, Henning Stöckmann, 2018, Journal of medicinal chemistry.

Potent and selective inhibitors of CDPK1 from T. gondii and C. parvum based on a 5-aminopyrazole-4-carboxamide scaffold.

Dustin J Maly, K. Comess, C. Verlinde, 2014, ACS medicinal chemistry letters.

Affinity-based screening techniques for enhancing lead discovery.

Mark E Schurdak, Kenneth M Comess, K. Comess, 2004, Current opinion in drug discovery & development.

A specific inhibitor of PfCDPK4 blocks malaria transmission: chemical-genetic validation.

Dustin J Maly, X. Su, K. Comess, 2014, Journal of Infectious Diseases.

Emerging Approaches for the Identification of Protein Targets of Small Molecules - A Practitioners' Perspective.

P. Richardson, K. Comess, A. Vasudevan, 2018, Journal of Medicinal Chemistry.

The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.

Mikkel A. Algire, Justin D Dietrich, A. Petros, 2017, Nature chemical biology.

Library Screening Using Ultrafiltration and Mass Spectrometry

K. Comess, T. Cloutier, 2007 .