Jill M. Wetter

发表

Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design.

S. C. Panchal, Philip B. Cox, P. Hajduk, 2020, Journal of medicinal chemistry.

Identification of (R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea (ABT-102) as a potent TRPV1 antagonist for pain management.

A. Gomtsyan, Jill M. Wetter, J. Sullivan, 2008, Journal of medicinal chemistry.

Correlation between brain/plasma ratios and efficacy in neuropathic pain models of selective metabotropic glutamate receptor 1 antagonists.

Jill M. Wetter, J. Brioni, S. Baker, 2006, Bioorganic & medicinal chemistry letters.

Novel heterocyclic-substituted benzofuran histamine H3 receptor antagonists: in vitro properties, drug-likeness, and behavioral activity.

K. Browman, Jill M. Wetter, G. Diaz, 2007, Biochemical pharmacology.

Pharmacological characterization of A-960656, a histamine H₃ receptor antagonist with efficacy in animal models of osteoarthritis and neuropathic pain.

Jill M. Wetter, G. Diaz, J. Brioni, 2012, European journal of pharmacology.

Efficacy in Cognition and Schizophrenia of a Potent and Selective Histamine H 3 Receptor Antagonist

Min Zhang, K. Browman, Jill M. Wetter, 2005 .

Metabolism and disposition of ABT-894, a novel α4β2 neuronal acetylcholine receptor agonist, in mice and monkeys

Jill M. Wetter, Hong Liu, P. Stuart, 2014, Xenobiotica; the fate of foreign compounds in biological systems.

A-412997 is a selective dopamine D4 receptor agonist in rats

Jill M. Wetter, J. Brioni, R. Moreland, 2005, Pharmacology Biochemistry and Behavior.

Enrichment with wood blocks does not affect toxicity assessment in an exploratory toxicology model using Sprague-Dawley rats.

Jill M. Wetter, B. Dayton, W. Buck, 2014, Journal of the American Association for Laboratory Animal Science : JAALAS.

2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist

D. Donnelly-roberts, Jill M. Wetter, M. Nakane, 2005, Neuropharmacology.

Alpha-methylation at benzylic fragment of N-aryl-N'-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain model.

A. Gomtsyan, Jill M. Wetter, Chih-Hung Lee, 2007, Bioorganic & medicinal chemistry letters.

Structure-activity studies of a novel series of 5,6-fused heteroaromatic ureas as TRPV1 antagonists.

A. Gomtsyan, Jill M. Wetter, J. Segreti, 2006, Bioorganic & Medicinal Chemistry.

Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties.

A. Gomtsyan, Jill M. Wetter, Chih-Hung Lee, 2005, Journal of medicinal chemistry.

Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction.

D. Donnelly-roberts, Jill M. Wetter, G. Gintant, 2006, Journal of medicinal chemistry.

Synthesis, potency, and in vivo profiles of quinoline containing histamine H3 receptor inverse agonists.

K. Browman, Jill M. Wetter, R. Fryer, 2007, Journal of medicinal chemistry.

Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models.

Jill M. Wetter, M. McPherson, J. Sullivan, 2008, Journal of medicinal chemistry.

Synthesis and SAR of 5-amino- and 5-(aminomethyl)benzofuran histamine H3 receptor antagonists with improved potency.

Jill M. Wetter, A. Hancock, K. Marsh, 2005, Journal of medicinal chemistry.

Pharmacological Properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological Characterization and Broad Preclinical Efficacy in Cognition and Schizophrenia of a Potent and Selective Histamine H3 Receptor Antagonist

Min Zhang, K. Browman, Jill M. Wetter, 2005, Journal of Pharmacology and Experimental Therapeutics.

Pharmacological Properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: I. Potent and Selective Histamine H3 Receptor Antagonist with Drug-Like Properties

Thomas R. Miller, Gerard B. Fox, Jill M. Wetter, 2005, Journal of Pharmacology and Experimental Therapeutics.

Structure-activity studies on a series of a 2-aminopyrimidine-containing histamine H4 receptor ligands.

Jill M. Wetter, U. Warrior, M. McPherson, 2008, Journal of medicinal chemistry.

H4 receptor antagonism exhibits anti-nociceptive effects in inflammatory and neuropathic pain models in rats

Jill M. Wetter, J. Brioni, S. Baker, 2010, Pharmacology Biochemistry and Behavior.

Antinociceptive effects of histamine H3 receptor antagonist in the preclinical models of pain in rats and the involvement of central noradrenergic systems

Jill M. Wetter, J. Brioni, M. Decker, 2010, Brain Research.

In vitro structure-activity relationship and in vivo characterization of 1-(aryl)-3-(4-(amino)benzyl)urea transient receptor potential vanilloid 1 antagonists.

A. Gomtsyan, Jill M. Wetter, Chih-Hung Lee, 2007, Journal of medicinal chemistry.

Diaryldiamines with dual inhibition of the histamine H(3) receptor and the norepinephrine transporter and the efficacy of 4-(3-(methylamino)-1-phenylpropyl)-6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol in pain.

Jill M. Wetter, J. Brioni, P. Honore, 2010, Journal of medicinal chemistry.

Pharmacological Properties of ABT-239: II. Neurophysiological Characterization and Broad Preclinical Efficacy in Cognition and Schizophrenia of a Potent and Selective Histamine H3 Receptor Antagonist

K. Browman, Jill M. Wetter, R. Porsolt, 2004 .

The alkaloid conessine and analogues as potent histamine H3 receptor antagonists.

K. Browman, Jill M. Wetter, A. Hancock, 2008, Journal of medicinal chemistry.

cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.

Jill M. Wetter, J. Brioni, P. Chandran, 2008, Journal of medicinal chemistry.

Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca²⁺ channel blockers with analgesic activity.

Jill M. Wetter, R. Henry, A. Swensen, 2012, Bioorganic & medicinal chemistry.