Chaohong Sun

发表

Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design.

S. C. Panchal, Philip B. Cox, P. Hajduk, 2020, Journal of medicinal chemistry.

Utilization of NMR-derived fragment leads in drug design.

P. Hajduk, J. R. Huth, Chaohong Sun, 2005, Methods in enzymology.

Discovery of a novel small molecule binding site of human survivin.

Jun Chen, Saul H Rosenberg, Kenneth M Comess, 2007, Bioorganic & medicinal chemistry letters.

Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases.

Hua Tang, Bo Liu, Gang Liu, 2011, ACS chemical biology.

NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP

Stephen W. Fesik, A. Gunasekera, Chaohong Sun, 1999, Nature.

NMR Structure and Mutagenesis of the Third Bir Domain of the Inhibitor of Apoptosis Protein XIAP*

Stephen W. Fesik, A. Gunasekera, Chaohong Sun, 2000, The Journal of Biological Chemistry.

Non-peptidic small molecule inhibitors of XIAP.

Chaohong Sun, R. Meadows, E. Olejniczak, 2005, Bioorganic & medicinal chemistry letters.

Nuclear magnetic resonance structural studies of a potassium channel-charybdotoxin complex.

A. Gunasekera, P. Hajduk, D. Song, 2005, Biochemistry.

Biochemical and biophysical characterization of unique switch pocket inhibitors of p38α.

P. Hajduk, S. Swann, Chaohong Sun, 2010, Bioorganic & medicinal chemistry letters.

Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity.

Chaohong Sun, E. Olejniczak, Eric F. Johnson, 2006, Journal of medicinal chemistry.

Targeting lysine specific demethylase 4A (KDM4A) tandem TUDOR domain - A fragment based approach.

A. Petros, Chaohong Sun, R. Henry, 2018, Bioorganic & medicinal chemistry letters.

Are We There Yet? Applying Thermodynamic and Kinetic Profiling on Embryonic Ectoderm Development (EED) Hit-to-Lead Program.

S. C. Panchal, A. Vasudevan, Chaohong Sun, 2017, Journal of medicinal chemistry.

Kinase-deficient BTK mutants confer ibrutinib resistance through activation of the kinase HCK

A. Chakraborty, Chaohong Sun, Xiaodong Huang, 2022, Science Signaling.

Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer

L. Lam, Chaohong Sun, S. Rosenberg, 2020, Nature.

Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor.

Chaohong Sun, L. Hasvold, Chang H. Park, 2017, Journal of Medicinal Chemistry.

Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site

Justin D Dietrich, A. Petros, P. Richardson, 2022, Scientific Reports.

Structural Basis for the Inhibition of Caspase-3 by XIAP

R. Liddington, R. Schwarzenbacher, Chaohong Sun, 2001, Cell.

Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8.

A. Petros, Chaohong Sun, M. Vedadi, 2016, ACS medicinal chemistry letters.

High-level bacterial expression and purification of human SirT2 protein for NMR studies.

P. Hajduk, D. Song, P. Richardson, 2006, Protein expression and purification.

Complete 'H, 13C, and 15N NMR and secondary structure of human in the fully reduced form resonance assignments glutaredoxin rn

Chaohong Sun, J. Bushweller, '. JOHNH.BUSHWELLER, 2002 .

Quantitative ligand and receptor binding studies reveal the mechanism of interleukin-36 (IL-36) pathway activation

P. Richardson, Chaohong Sun, E. DiGiammarino, 2017, The Journal of Biological Chemistry.

Correction to Structure-Guided Design of a Series of MCL-1 Inhibitors with High Affinity and Selectivity.

Scott A. Erickson, C. Tse, A. Petros, 2015, Journal of medicinal chemistry.

SAR by NMR: An Analysis of Potency Gains Realized Through Fragment‐linking and Fragment‐elaboration Strategies for Lead Generation

P. Hajduk, J. R. Huth, Chaohong Sun, 2006 .

The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity.

Mikkel A. Algire, K. Comess, Chaohong Sun, 2017, Nature chemical biology.

Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.

A. Petros, Chaohong Sun, P. Kovar, 2017, Journal of medicinal chemistry.

NMR in Pharmacokinetic and Pharmacodynamic Profiling

P. Hajduk, J. R. Huth, Chaohong Sun, 2005, Chembiochem : a European journal of chemical biology.

Regulation of the Apaf-1/Caspase-9 Apoptosome by Caspase-3 and XIAP*

Chaohong Sun, S. Fesik, R. Armstrong, 2003, The Journal of Biological Chemistry.

The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.

Jun Guo, Kenneth M Comess, Haizhong Zhu, 2017, Nature chemical biology.

Solution structure of human survivin and its binding interface with Smac/Diablo.

Chaohong Sun, E. Olejniczak, Zhihong Liu, 2005, Biochemistry.

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

Stephen F. Betz, Stephen W. Fesik, Edward T. Olejniczak, 2000, Nature.

Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.

Saul H Rosenberg, Chaohong Sun, R. Meadows, 2004, Journal of medicinal chemistry.

Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity.

Scott A. Erickson, C. Tse, A. Petros, 2015, Journal of medicinal chemistry.

Fragment-Based Discovery of an Apolipoprotein E4 (apoE4) Stabilizer.

Justin D Dietrich, A. Petros, V. Stoll, 2019, Journal of medicinal chemistry.

Overexpression, Purification, and Biophysical Characterization of the Heterodimerization Domain of the Core-binding Factor β Subunit*

J. Kelley, Chaohong Sun, J. Bushweller, 1998, The Journal of Biological Chemistry.

Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

Chunaram Choudhary, Saul H. Rosenberg, Ronen Marmorstein, 2017, Nature.

Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5

K. Longenecker, Chaohong Sun, D. Kempf, 2017, Acta crystallographica. Section F, Structural biology communications.

The HPK1 Inhibitor A-745 Verifies the Potential of Modulating T Cell Kinase Signaling for Immunotherapy.

Ryan A McClure, K. Longenecker, Chaohong Sun, 2022, ACS chemical biology.

Species differences and molecular determinant of TRPA1 cold sensitivity

Chaohong Sun, Donghee Kim, J. Xu, 2013, Nature Communications.

Molecular Determinants of Species-Specific Activation or Blockade of TRPA1 Channels

P. Hajduk, J. R. Huth, Chaohong Sun, 2008, The Journal of Neuroscience.

Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315.

A. Vasudevan, Chaohong Sun, C. Jakob, 2018, Journal of medicinal chemistry.

The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes

Chaohong Sun, Y. Wong, R. Edalji, 2018, eLife.

Structure-Based Design of A-1293102, a Potent and Selective BCL-XL Inhibitor.

Chaohong Sun, Z. Tao, P. Kovar, 2021, ACS medicinal chemistry letters.

Small Molecule IL-36 gamma Antagonist as a Novel Therapeutic Approach for Plaque Psoriasis.

P. Richardson, Chaohong Sun, R. Henry, 2019 .

Small Molecule IL-36γ Antagonist as a Novel Therapeutic Approach for Plaque Psoriasis

P. Richardson, Chaohong Sun, R. Henry, 2019, Scientific Reports.

Fragment-based lead discovery: challenges and opportunities

Philip J. Hajduk, Andrew M. Petros, Chaohong Sun, 2011, J. Comput. Aided Mol. Des..

NMR-based fragment screening and lead discovery accelerated by principal component analysis

A. Petros, Chaohong Sun, S. V. Van Doren, 2019, Journal of Biomolecular NMR.

Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS

P. Hajduk, D. Song, P. Richardson, 2007, Proceedings of the National Academy of Sciences.

Discovery of a Potent and Selective Covalent p300/CBP Inhibitor.

Mikkel A. Algire, Chaohong Sun, K. Bromberg, 2021, ACS medicinal chemistry letters.

Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis In Vivo.

Mikkel A. Algire, Chaohong Sun, J. Randolph, 2023, Journal of medicinal chemistry.

Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.

Renaldo Mendoza, Saul H Rosenberg, Cheol-Min Park, 2010, Bioorganic & medicinal chemistry letters.

Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein.

Chang Park, S. Swann, A. Petros, 2014, Bioorganic & medicinal chemistry letters.

Labeled Ligand Displacement: Extending NMR-Based Screening of Protein Targets.

P. Hajduk, S. Swann, A. Petros, 2010, ACS Medicinal Chemistry Letters.

Cracking the molecular weight barrier: fragment screening of an aminotransferase using an NMR-based functional assay.

Walter F. Leise, A. Petros, Chaohong Sun, 2011, Bioorganic & medicinal chemistry letters.

Methylpyrrole inhibitors of BET bromodomains.

A. Petros, Chaohong Sun, N. Soni, 2017, Bioorganic & medicinal chemistry letters.

Insights into the conformation and self-association of a concentrated monoclonal antibody using isothermal chemical denaturation and nuclear magnetic resonance.

A. Petros, Chaohong Sun, C. Radziejewski, 2021, Journal of pharmaceutical sciences.

Utility of NMR in lead optimization: fragment-based approaches.

J. R. Huth, Chaohong Sun, 2002, Combinatorial chemistry & high throughput screening.

Complete 1H, 13C, and 15N NMR resonance assignments and secondary structure of human glutaredoxin in the fully reduced form

Chaohong Sun, A. Holmgren, J. Bushweller, 1997, Protein science : a publication of the Protein Society.

The Ig fold of the core binding factor alpha Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains.

Chaohong Sun, J. Bushweller, N. Speck, 1999, Structure.

Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

Mikkel A. Algire, L. Lam, Chaohong Sun, 2017, Nature.

Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode.

Celerino Abad-Zapatero, Chaohong Sun, C. Abad-Zapatero, 2006, Bioorganic & medicinal chemistry letters.

SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding.

Hongyu Zhao, Ying Wang, Zhiqin Ji, 2017, Bioorganic & medicinal chemistry letters.

Nuclear magnetic resonance in target profiling and compound file enhancement.

P. Hajduk, Chaohong Sun, 2006, Current opinion in drug discovery & development.

Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex

Chaohong Sun, C. Nasveschuk, Gesine K. Veits, 2024, Communications chemistry.