R. Zinkernagel

发表

R. Zinkernagel, R. Ahmed, B. Rouse, 2006 .

Role of virus and host variables in virus persistence or immunopathological disease caused by a non-cytolytic virus.

R. Zinkernagel, M. Battegay, D. Moskophidis, 1995, The Journal of general virology.

Early Antibodies Specific for the Neutralizing Epitope on the Receptor Binding Subunit of the Lymphocytic Choriomeningitis Virus Glycoprotein Fail To Neutralize the Virus

J. Weber, R. Zinkernagel, A. Wepf, 2007, Journal of Virology.

Antiviral antibody responses: the two extremes of a wide spectrum

Rolf M. Zinkernagel, Hans Hengartner, R. Zinkernagel, 2006, Nature Reviews Immunology.

Formalin inactivation of vesicular stomatitis virus impairs T-cell- but not T-help-independent B-cell responses

R. Zinkernagel, T. Kündig, M. Bachmann, 1993, Journal of virology.

Dendritic Cells Induce Autoimmune Diabetes and Maintain Disease via De Novo Formation of Local Lymphoid Tissue

R. Zinkernagel, B. Ludewig, H. Hengartner, 1998, The Journal of experimental medicine.

Self Antigens Expressed by Solid Tumors Do Not Efficiently Stimulate Naive or Activated T Cells: Implications for Immunotherapy

D. Hanahan, R. Zinkernagel, D. Speiser, 1997, The Journal of experimental medicine.

Lower receptor avidity required for thymic clonal deletion than for effector T-cell function

H. Pircher, R. Zinkernagel, D. Moskophidis, 1991, Nature.

Immunodeficiency and Chronic Myelogenous Leukemia-like Syndrome in Mice with a Targeted Mutation of the ICSBP Gene

J. Waring, R. Zinkernagel, F. Rosenbauer, 1996, Cell.

Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system

R. Zinkernagel, P. Doherty, R. Zinkernagel, 1974, Nature.

Associations between major histocompatibility antigens and susceptibility to disease.

R. Zinkernagel, 1979, Annual review of microbiology.

Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes

Rolf M. Zinkernagel, P. Klenerman, R. Zinkernagel, 1998, Nature.

Intrathymic elimination of Mlsa-reactive (V beta 6+) cells during neonatal tolerance induction to Mlsa-encoded antigens

R. Zinkernagel, H. Macdonald, J. Louis, 1988, The Journal of experimental medicine.

Immune surveillance against a solid tumor fails because of immunological ignorance.

P. Klenerman, R. Zinkernagel, B. Ludewig, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Roles of tumour localization, second signals and cross priming in cytotoxic T-cell induction

Rolf M. Zinkernagel, Hans Hengartner, Adrian F. Ochsenbein, 2001, Nature.

A BIOLOGICAL ROLE FOR THE MAJOR HISTOCOMPATIBILITY ANTIGENS

R. Zinkernagel, P. Doherty, P. C Doherty, 1975, The Lancet.

Intralymphatic immunization enhances DNA vaccination

R. Zinkernagel, I. Erdmann, T. Kündig, 2001, Proceedings of the National Academy of Sciences of the United States of America.

A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria.

R. Zinkernagel, A. Macpherson, H. Hengartner, 2000, Science.

The impact of variation in the number of CD8(+) T-cell precursors on the outcome of virus infection.

R M Zinkernagel, P. Klenerman, R. Zinkernagel, 1998, Cellular immunology.

Restriction by H-2 gene complex of transfer of cell-mediated immunity to Listeria monocytogenes

R. Zinkernagel, R. Zinkernagel, 1974, Nature.

H-2 restriction of cell-mediated immunity to an intracellular bacterium: effector T cells are specific for Listeria antigen in association with H-21 region-coded self-markers

R. Zinkernagel, U. Kees, W. Davidson, 1977, The Journal of experimental medicine.

T-cell independent IgM and enduring protective IgG antibodies induced by chimeric measles viruses

M. Billeter, R. Zinkernagel, T. Fehr, 1998, Nature Medicine.

Immunotherapy with Dendritic Cells Directed against Tumor Antigens Shared with Normal Host Cells Results in Severe Autoimmune Disease

R. Zinkernagel, B. Ludewig, H. Hengartner, 2000, The Journal of experimental medicine.

Immune Protection vs. Immunopathology vs. Autoimmunity: A Question of Balance and of Knowledge

R. Zinkernagel, 1993, Brain pathology.

On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?

R. Zinkernagel, J. Klein, P. Klein, 1978, The Journal of experimental medicine.

H-2 compatibility requirement for virus-specific T cell-mediated effector functions in vivo. I. Specificity of T cells conferring antiviral protection against lymphocytic choriomeningitis virus is associated with H-2K and H-2D.

R. Zinkernagel, R. Welsh, R. M. Zinkernagel, 1976, Journal of immunology.

Antiviral protection by virus-immune cytotoxic T cells: infected target cells are lysed before infectious virus progeny is assembled

R. Zinkernagel, A. Althage, 1977, The Journal of experimental medicine.

Distinct sequence of negative or positive selection implied by thymocyte T-cell receptor densities

H. Pircher, R. Zinkernagel, P. Ohashi, 1990, Nature.

Antigen persistence and time of T-cell tolerization determine the efficacy of tolerization protocols for prevention of skin graft rejection

H. Pircher, R. Zinkernagel, S. Ehl, 1998, Nature Medicine.

Viral and Bacterial Infections Interfere with Peripheral Tolerance Induction and Activate CD8+ T Cells to Cause Immunopathology

H. Pircher, R. Zinkernagel, S. Ehl, 1998, The Journal of experimental medicine.

Transplantation tolerance from a historical perspective

T. Starzl, R. Zinkernagel, 2001, Nature Reviews Immunology.

Responses to Cohn's Discussion on the Zinkernagel–Hengartner ‘Credo 2004’

R. Zinkernagel, H. Hengartner, 2005, Scandinavian journal of immunology.

Pillars Article: Immunological Surveillance against Altered Self Components by Sensitised T Lymphocytes in Lymphocytic Choriomeningitis. Nature, 1974, 251: 547–548.

R. Zinkernagel, P. Doherty, 2004 .

Multiple immune abnormalities in tumor necrosis factor and lymphotoxin-α double-deficient mice

R. Zinkernagel, B. Ryffel, F. Padova, 1996 .

FTY720 Immunosuppression Impairs Effector T Cell Peripheral Homing Without Affecting Induction, Expansion, and Memory1

R. Zinkernagel, V. Brinkmann, H. Hengartner, 2000, The Journal of Immunology.

H-2 restriction of virus-specific cytotoxicity across the H-2 barrier. Separate effector T-cell specificities are associated with self-H-2 and with the tolerated allogeneic H-2 in chimeras

R. Zinkernagel, 1976, The Journal of experimental medicine.

Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses

R. Zinkernagel, R. Landmann, A. Bergthaler, 2006, Proceedings of the National Academy of Sciences.

Distinct Patterns of Virus‐Specific T Cell‐Mediated Cytolysis of Transformed versus Primary Target Cells

R. Zinkernagel, H. Hengartner, J. Baenziger, 1988, Scandinavian journal of immunology.

Effects of Promyelocytic Leukemia Protein on Virus-Host Balance

P. Pandolfi, P. Klenerman, R. Zinkernagel, 2002, Journal of Virology.

T cell priming versus T cell tolerance induced by synthetic peptides

H. Pircher, R. Zinkernagel, H. Hengartner, 1995, The Journal of experimental medicine.

Peptide-induced antiviral protection by cytotoxic T cells.

R. Zinkernagel, H. Hengartner, M. Schulz, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Protective Immunity Does Not Correlate with the Hierarchy of Virus-specific Cytotoxic T Cell Responses to Naturally Processed Peptides

H. Rammensee, R. Zinkernagel, H. Hengartner, 1998, The Journal of experimental medicine.

Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure.

R. Zinkernagel, H. Hengartner, B. Odermatt, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Dendritic Cells Efficiently Induce Protective Antiviral Immunity

R. Zinkernagel, S. Ehl, B. Ludewig, 1998, Journal of Virology.

Donor cell persistence and activation‐induced unresponsiveness of peripheral CD8+ T cells

R. Zinkernagel, S. Ehl, J. Hombach, 2000, European journal of immunology.

Antiviral immunity.

R. Zinkernagel, H. Hengartner, H. Hengartner, 1997, Immunology today.

T helper cell‐independent neutralizing B cell response against vesicular stomatitis virus: Role of antigen patterns in B cell induction?

R. Zinkernagel, M. Bachmann, H. Hengartner, 1995, European journal of immunology.

Aggravation of viral hepatitis by platelet-derived serotonin

M. Kurrer, R. Zinkernagel, B. Ludewig, 2008, Nature Medicine.

Characterization of virus‐specific cytotoxic T cell clones from allogeneic bone marrow chimeras

H. Pircher, R. Zinkernagel, M. Schilham, 1987, European journal of immunology.

Functional in vivo MHC class II loading by endogenously synthesized glycoprotein during viral infection.

R. Zinkernagel, C. Benoist, A. Oxenius, 1997, Journal of immunology.

The Challenges of an HIV Vaccine Enterprise

R. Zinkernagel, 2004, Science.

Nuclear myxovirus-resistance protein Mx is a minor histocompatibility antigen.

R. Zinkernagel, D. Speiser, O. Haller, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Scrapie Pathogenesis in Subclinically Infected B-Cell-Deficient Mice

A. Aguzzi, R. Zinkernagel, I. Hegyi, 1999, Journal of Virology.

Hierarchies of antigen‐specific cytotoxic T‐cell responses

R. Zinkernagel, H. Hengartner, A. Gallimore, 1998, Immunological reviews.

Immunodominant T cell epitope from signal sequence.

R. Zinkernagel, M. Buchmeier, 1992, Science.

Specific cytotoxic T cells eliminate cells producing neutralizing antibodies

R. Zinkernagel, O. Planz, H. Hengartner, 1996, Nature.

Peptide-induced T-cell tolerance to prevent autoimmune diabetes in a transgenic mouse model.

H. Pircher, R. Zinkernagel, P. Ohashi, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Requirement for Neutralizing Antibodies to Control Bone Marrow Transplantation-Associated Persistent Viral Infection and to Reduce Immunopathology1

R. Zinkernagel, M. van den Broek, A. Navarini, 2005, The Journal of Immunology.

Enhanced tumor susceptibility of immunocompetent mice infected with lymphocytic choriomeningitis virus

R. Zinkernagel, H. Hengartner, M. Kohler, 2005, Cancer Immunology, Immunotherapy.

Addendum: Specific cytotoxic T cells eliminate cells producing neutralizing antibodies

R. Zinkernagel, O. Planz, H. Hengartner, 1996, Nature.

LEFLUNOMIDE-MEDIATED SUPPRESSION OF ANTIVIRAL ANTIBODY AND T CELL RESPONSES: DIFFERENTIAL RESTORATION BY URIDINE1

R. Zinkernagel, T. Fehr, A. Ochsenbein, 2001, Transplantation.

Immunodeficiency of alymphoplasia mice (aly/aly) in vivo: structural defect of secondary lymphoid organs and functional B cell defect

R. Zinkernagel, H. Hengartner, U. Karrer, 2000, European journal of immunology.

In vivo selection of neutralization-resistant virus variants but no evidence of B cell tolerance in lymphocytic choriomeningitis virus carrier mice expressing a transgenic virus-neutralizing antibody.

R. Zinkernagel, H. Hengartner, U. Kalinke, 1999, Journal of immunology.

Virus-induced Transient Bone Marrow Aplasia: Major Role of Interferon- (cid:97) / (cid:98) during Acute Infection with the Noncytopathic Lymphocytic Choriomeningitis Virus

R. Zinkernagel, J. Fehr, H. Hengartner, 1997 .

Lymphocyte‐mediated Cytotoxicity in vitro and in vivo: Mechanisms and Significance

R. Zinkernagel, H. Hengartner, B. Ledermann, 1995, Immunological reviews.

Enhanced positive selection of a transgenic TCR by a restriction element that does not permit negative selection.

H. Pircher, R. Zinkernagel, P. Ohashi, 1993, International Immunology.

Tolerance, Autoimmunity and Immunopathology

H. Pircher, R. Zinkernagel, T. Rülicke, 1993 .

Viruses Escaping Immunological Surveillance

H. Pircher, R. Zinkernagel, M. Battegay, 1993 .

Virally induced immunosuppression.

R. Zinkernagel, H. Hengartner, 1992, Current opinion in immunology.

Immunosuppression by lymphocytic choriomeningitis virus infection: competent effector T and B cells but impaired antigen presentation

R. Zinkernagel, D. Moskophidis, T. Kündig, 1992, European journal of immunology.

Vaccination or tolerance to prevent diabetes

R. Zinkernagel, P. Ohashi, H. Hengartner, 1992, European journal of immunology.

Extrathymic positive selection of αβ T-cell precursors in nude mice

R. Zinkernagel, D. Speiser, Ursula Stiibi, 1992, Nature.

Production of random classes of immunoglobulins in brain tissue during persistent viral infection paralleled by secretion of interleukin-6 (IL-6) but not IL-4, IL-5, and gamma interferon

R. Zinkernagel, K. Frei, D. Moskophidis, 1991, Journal of virology.

Virus-triggered immune suppression in mice caused by virus-specific cytotoxic T cells

R. Zinkernagel, T. Leist, E. Rüedi, 1988, The Journal of experimental medicine.

Increased bactericidal macrophage activity induced by immunological stimuli is dependent on interferon (IFN)‐Γ

R. Zinkernagel, T. Leist, R. Heuchel, 1988, European journal of immunology.

Clearance of lymphocytic choriomeningitis virus in antibody- and B-cell-deprived mice

R. Zinkernagel, H. Bazin, H. Hengartner, 1988, Journal of virology.

Induction or prevention of immunopathological disease by cloned cytotoxic T cell lines specific for lymphocytic choriomeningitis virus

R. Zinkernagel, H. Hengartner, G. Cole, 1986, European journal of immunology.

T cell-mediated hepatitis in mice infected with lymphocytic choriomeningitis virus. Liver cell destruction by H-2 class I- restricted virus-specific cytotoxic T cells as a physiological correlate of the 51Cr-release assay?

R. Zinkernagel, H. Hengartner, A. Cerny, 1986, The Journal of experimental medicine.

CYTOTOXIC THYMUS-DERIVED LYMPHOCYTES IN CEREBROSPINAL FLUID OF MICE WITH LYMPHOCYTIC CHORIOMENINGITIS

R. Zinkernagel, P. Doherty, 1973, The Journal of experimental medicine.

Heterospecific cytotoxic cell activity induced during the first three days of acute lymphocytic choriomeningitis virus infection in mice

R. Zinkernagel, R. Welsh, ROLF M. ZINKERNAGEL, 1977, Nature.

Cytotoxic cells induced during lymphocytic choriomeningitis virus infection of mice. II. "Specificities" of the natural killer cells.

R. Zinkernagel, R. Welsh, L. Hallenbeck, 1979, Journal of immunology.

Secondary cytotoxic cell response to lymphocytic choriomeningitis virus II. Nature and specificity of effector cells.

R. Zinkernagel, P. Doherty, R. Blanden, 1976, Immunology.

ProtectionMechanisms of Neonatal Mucosal Antibody

R. Zinkernagel, A. Macpherson, B. Odermatt, 2006 .

Tumor necrosis factor alpha in cerebrospinal fluid during bacterial, but not viral, meningitis. Evaluation in murine model infections and in patients

R. Zinkernagel, K. Frei, A. Fontana, 1988, The Journal of experimental medicine.

Role of tumor necrosis factor in Listeria resistance of nude mice

R. Zinkernagel, K. Frei, T. Leist, 2004, Medical Microbiology and Immunology.

Acute rejection of vascular heart allografts by perforin‐deficient mice

R. Zinkernagel, T. Meerloo, H. Hengartner, 1995, European journal of immunology.

Transforming growth factor-beta inhibits the generation of cytotoxic T cells in virus-infected mice.

R. Zinkernagel, K. Frei, A. Fontana, 1989, Journal of immunology.

Mice lacking the tumour necrosis factor receptor 1 are resistant to IMF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

R. Zinkernagel, W. Lesslauer, H. Bluethmann, 1993, Nature.

Antiviral B Cell Memory in the Absence of Mature Follicular Dendritic Cell Networks and Classical Germinal Centers in TNFR1−/− Mice1

R. Zinkernagel, A. Oxenius, M. Bachmann, 2000, The Journal of Immunology.

Aplastic Anemia Rescued by Exhaustion of Cytokine-secreting CD8+ T Cells in Persistent Infection with Lymphocytic Choriomeningitis Virus

R. Zinkernagel, M. van den Broek, H. Bluethmann, 1998, The Journal of experimental medicine.

CD8+ T cell‐mediated protection against an intracellular bacterium by perforin‐dependent cytotoxicity

R. Zinkernagel, H. Hengartner, B. Ledermann, 1994, European journal of immunology.

Acrucial role forBcells in neuroinvasivescrapie

A. Aguzzi, R. Zinkernagel, A. Raeber, 2022 .

Thymic selection of H-2-incompatible bone marrow cells in SCID mice. Differences in T help for induction of B cell IgG responses versus cytotoxic T cells

R. Zinkernagel, H. Hengartner, A. Althage, 1988, The Journal of experimental medicine.

Immunity to lymphocytic choriomeningitis virus in B cell‐depleted mice: evidence for B cell and antibody‐independent protection by memory T cells

R. Zinkernagel, H. Bazin, H. Hengartner, 1986, European journal of immunology.

Perforin‐independent regulation of dendritic cell homeostasis by CD8+ T cells in vivo: implications for adaptive immunotherapy

R. Zinkernagel, B. Ludewig, H. Hengartner, 2001, European journal of immunology.

Immunological memory: lessons from the past and a look to the future

M. Netea, R. Zinkernagel, K. Rajewsky, 2016, Nature Reviews Immunology.

THE ROLE OF MAJOR HISTOCOMPATIBILITY ANTIGENS IN CELL-MEDIATED IMMUNITY TO VIRUS INFECTIONS

R. Zinkernagel, P. Doherty, 1976 .

Role of T helper cell precursor frequency on vesicular stomatitis virus neutralizing antibody responses in a T cell receptor β chain transgenic mouse

H. Pircher, R. Zinkernagel, T. Rülicke, 1995, European journal of immunology.

AntiviralNiches by B and Th Cells Augments CXCR 5-Dependent Seeding of Follicular

R. Zinkernagel, M. Muramatsu, T. Junt, 2005 .

CXCR5-Dependent Seeding of Follicular Niches by B and Th Cells Augments Antiviral B Cell Responses1

R. Zinkernagel, M. Muramatsu, T. Junt, 2005, The Journal of Immunology.

Immunoreactivity of long lived H-2 incompatible irradiation chimeras (H-2d leads to H-2b).

R. Zinkernagel, G. Maestroni, W. Pierpaoli, 1982, Immunology.

Immunoreactivity of long lived h-2 incompatible irradiation chimeras (h-2d-h-2b).

R. Zinkernagel, G. Maestroni, W. Pierpaoli, 1982 .

Mechanisms of virus-induced autoimmune disease

R. Zinkernagel, B. Ludewig, H. Hengartner, 2000 .

Development of insulitis without diabetes in transgenic mice lacking perforin-dependent cytotoxicity

R. Zinkernagel, P. Ohashi, H. Hengartner, 1996, The Journal of experimental medicine.

Reduced Incidence and Delayed Onset of Diabetes in Perforin-deficient Nonobese Diabetic Mice

R. Zinkernagel, T. Mak, H. Hengartner, 1997, The Journal of experimental medicine.

Postnatal disappearance of self-reactive (V beta 6+) cells from the thymus of Mlsa mice. Implications for T cell development and autoimmunity

R. Zinkernagel, H. Macdonald, T. Pedrazzini, 1989, The Journal of experimental medicine.

Positive and negative selection of T cell receptor V beta domains controlled by distinct cell populations in the thymus

R. Zinkernagel, D. Speiser, H. Macdonald, 1989, The Journal of experimental medicine.

Cytotoxic T cell clone‐specific monoclonal antibodies used to select clonotypic antigen‐specific cytotoxic T cells

R. Zinkernagel, H. Acha‐Orbea, H. Hengartner, 1985, European journal of immunology.

Monovalent single‐chain Fv fragments and bivalent miniantibodies bound to vesicular stomatitis virus protect against lethal infection

R. Zinkernagel, A. Plückthun, H. Hengartner, 1996, European journal of immunology.

T cells causing immunological disease

H. Pircher, R. Zinkernagel, P. Ohashi, 2004, Springer Seminars in Immunopathology.

Tolerance induction by clonal deletion of CD4+8+ thymocytes in vitro does not require dedicated antigen‐presenting cells

H. Pircher, R. Zinkernagel, B. Kyewski, 1993, European journal of immunology.

Clonal deletion induced by either radioresistant thymic host cells or lymphohemopoietic donor cells at different stages of class I-restricted T cell ontogeny

H. Pircher, R. Zinkernagel, D. Speiser, 1992, The Journal of experimental medicine.

Neonatal tolerance to MIs-1a determinants: deletion or anergy of V beta 6+ T lymphocytes depending upon MHC compatibility of neonatally injected cells.

R. Zinkernagel, D. Speiser, H. Macdonald, 1991, International immunology.

Distinct fates of self-specific T cells developing in irradiation bone marrow chimeras: clonal deletion, clonal anergy, or in vitro responsiveness to self-Mls-1a controlled by hemopoietic cells in the thymus

R. Zinkernagel, D. Speiser, H. Macdonald, 1990, The Journal of experimental medicine.

Immune-Protection Versus Immunopathology by Antiviral T Cell Responses

H. Pircher, R. Zinkernagel, H. Hengartner, 1989 .

CD40-CD40 ligand interactions are critical in T-B cooperation but not for other anti-viral CD4+ T cell functions

R. Zinkernagel, A. Oxenius, M. Bachmann, 1996, The Journal of experimental medicine.

Effects of treatment with IL-2 receptor specific monoclonal antibody in mice. Inhibition of cytotoxic T cell responses but not of T help.

R. Zinkernagel, T. Leist, M. Kohler, 1989, Journal of immunology.

Long‐term maternal imprinting of the specific B cell repertoire by maternal antibodies

J. Weber, R. Zinkernagel, A. Macpherson, 2008, European journal of immunology.

Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8

A. Aguzzi, R. Zinkernagel, J. Kranich, 2008, The Journal of experimental medicine.

Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge 8

A. Aguzzi, R. Zinkernagel, J. Kranich, 2008 .

B Cell Activation State-Governed Formation of Germinal Centers following Viral Infection1

J. Weber, R. Zinkernagel, K. Fink, 2007, The Journal of Immunology.

Vaccination with two different vaccinia recombinant viruses: long-term inhibition of secondary vaccination.

R. Zinkernagel, T. Kündig, C. Kalberer, 1993, Vaccine.

Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling.

S. Akira, H. Pircher, R. Zinkernagel, 2006, The Journal of clinical investigation.

T-cell-mediated immunopathology in viral infections.

R. Zinkernagel, P. Doherty, 1974, Transplantation reviews.

Nonimmunogenic tumor cells may efficiently restimulate tumor antigen-specific cytotoxic T cells.

R. Zinkernagel, T. Kündig, M. Bachmann, 1993, Journal of immunology.

MHC-Disease Associations and T Cell-Mediated Immunopathology

R. Zinkernagel, 1988 .

Major histocompatibility gene complex‐disease associations may reflect T cell‐mediated immunopathology

R. Zinkernagel, 1986, European journal of clinical investigation.

Bystander Activation of Cytotoxic T Cells: Studies on the Mechanism and Evaluation of In Vivo Significance in a Transgenic Mouse Model

R. Zinkernagel, S. Ehl, J. Hombach, 1997, The Journal of experimental medicine.

Allogeneic beta-islet cells correct diabetes and resist immune rejection.

R. Zinkernagel, P. Aebischer, B. Thorens, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon‐I‐dependent manner in mice

R. Zinkernagel, B. Ludewig, S. Scheu, 2010, Hepatology.

plt/plt Mice of Organized Lymphoid T Cell Zones in Antiviral Immune Responses in the Absence

R. Zinkernagel, B. Ludewig, B. Odermatt, 2013 .

Expression of lymphotoxin beta governs immunity at two distinct levels

A. Aguzzi, R. Zinkernagel, M. Heikenwalder, 2006, European journal of immunology.

Antiviral Immune Responses in the Absence of Organized Lymphoid T Cell Zones in plt/plt Mice1

R. Zinkernagel, T. Junt, B. Ludewig, 2002, The Journal of Immunology.

Kinetics of protective antibodies are determined by the viral surface antigen.

R. Zinkernagel, T. Bächi, M. Whitt, 2004, The Journal of clinical investigation.

Persistence of lymphocytic choriomeningitis virus at very low levels in immune mice.

P. Klenerman, R. Zinkernagel, L. Hunziker, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Antiviral protection by vesicular stomatitis virus-specific antibodies in alpha/beta interferon receptor-deficient mice

R. Zinkernagel, U. Steinhoff, M. Aguet, 1995, Journal of virology.

Astrocytes as antigen-presenting cells. Part II: Unlike H-2K-dependent cytotoxic T cells, H-2Ia-restricted T cells are only stimulated in the presence of interferon-γ

H. Pircher, R. Zinkernagel, W. Fierz, 1986, Journal of Neuroimmunology.

Natural IgE production in the absence of MHC Class II cognate help.

R. Zinkernagel, K. McCoy, A. Macpherson, 2006, Immunity.

Correlates of Protective Viruses Damaging to HIV Infection

B. Haynes, R. Zinkernagel, A. Fauci, 1996, Science.

Correlates of Protective Viruses Damaging to HIV Infection.

R. Zinkernagel, H. Hengartner, 1996, Science.

Interferon gamma-producing gammadelta T cell-dependent antibody isotype switching in the absence of germinal center formation during virus infection.

R. Zinkernagel, H. Hengartner, K. Maloy, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Development of follicular dendritic cells in lymph nodes of B-cell-depleted mice

R. Zinkernagel, A. Cerny, P. Groscurth, 1988, Cell and Tissue Research.

IL-12 is not required for induction of type 1 cytokine responses in viral infections.

R. Zinkernagel, A. Oxenius, H. Hengartner, 1999, Journal of immunology.

IL-4 and IL-10 antagonize IL-12-mediated protection against acute vaccinia virus infection with a limited role of IFN-gamma and nitric oxide synthetase

R. Zinkernagel, M. Bachmann, M. Kopf, 2019 .

Viruses Know the Trick Responses in the Absence of Costimulation: Cutting Edge Commentary: Immune

R. Zinkernagel, M. Bachmann, Oxenius, 1998 .

Immunological tolerance to a non-cytopathic virus is not inheritable in mice.

R. Zinkernagel, L. Stitz, 1984, Immunology.

MyD88 protects from lethal encephalitis during infection with vesicular stomatitis virus

S. Akira, K. Honda, R. Zinkernagel, 2007, European journal of immunology.

Vaccine Design Implications for Splenectomized Patients and Reaching Secondary Lymphoid Organs: Antibody Responses with Antigen Dose Correlation of T Cell Independence of

R. Zinkernagel, H. Hengartner, B. Odermatt, 2000 .

IgD can largely substitute for loss of IgM function in B cells

R. Zinkernagel, F. Brombacher, G. Köhler, 1998, Nature.

Vesicular stomatitis virus Indiana glycoprotein as a T-cell-dependent and -independent antigen

R. Zinkernagel, M. Bachmann, H. Hengartner, 1994, Journal of virology.

On plasma cell longevity or brevity

R. Zinkernagel, 2014, Expert review of vaccines.

CD4+ T-cell induction and effector functions: a comparison of immunity against soluble antigens and viral infections.

R. Zinkernagel, A. Oxenius, H. Hengartner, 1998, Advances in immunology.

Correlation of anti-viral B cell responses and splenic morphology with expression of B cell-specific molecules.

R. Zinkernagel, T. Fehr, R. Torres, 2000, International immunology.

Antiviral immune responses of mice lacking MHC class II or its associated invariant chain.

R. Zinkernagel, C. Benoist, M. Battegay, 1996, Cellular immunology.

Fewer protective cytotoxic T-cell epitopes than T-helper-cell epitopes on vesicular stomatitis virus

R. Zinkernagel, T. Kündig, M. Bachmann, 1993, Journal of virology.

Virus-induced autoantibody response to a transgenic viral antigen

R. Zinkernagel, H. Hengartner, R. Lazzarini, 1990, Nature.

The role of antibodies in natural and acquired resistance of mice to vesicular stomatitis virus.

R. Zinkernagel, H. Hengartner, A. Cerny, 1988, Experimental cell biology.

Crystal‐ball gazing − the future of immunological research viewed from the cutting edge

R. Zinkernagel, I. Cohen, S. Holgate, 2006, Clinical and experimental immunology.

Antibody mediated suppression of secondary IgM response in nude mice against vesicular stomatitis virus.

R. Zinkernagel, S. Charan, 1986, Journal of immunology.

Target antigens for H-2-restricted vesicular stomatitis virus-specific cytotoxic T cells.

R. Zinkernagel, A. Althage, J. Holland, 1978, Journal of immunology.

Functional CD8+ but not CD4+ T cell responses develop independent of thymic epithelial MHC

R. Zinkernagel, W. Reith, M. van den Broek, 2006, Proceedings of the National Academy of Sciences.

Peripheral T cells in mice lacking p56lck do not express significant antiviral effector functions.

R. Zinkernagel, T. Mak, T. Kündig, 1993, Journal of immunology.

Different susceptibility of cytotoxic T cells to CD95 (Fas/Apo-1) ligand-mediated cell death after activation in vitro versus in vivo.

R. Zinkernagel, S. Ehl, U. Hoffmann‐Rohrer, 1996, Journal of immunology.

Virus or a hapten‐carrier complex can activate autoreactive B cells by providing linked T help

R. Zinkernagel, U. Steinhoff, H. Hengartner, 1994, European journal of immunology.

Functional analysis of T lymphocyte subsets in antiviral host defense.

R. Zinkernagel, H. Waldmann, S. Cobbold, 1987, Journal of immunology.

Induction of IgE and allergic‐type responses in fur mite‐infested mice

R. Zinkernagel, K. McCoy, H. Hengartner, 2006, European journal of immunology.

Effect of rabbit anti-asialo GM1 treatment in vivo or with anti-asialo GM1 plus complement in vitro on cytotoxic T cell activities.

H. Pircher, R. Zinkernagel, L. Stitz, 1986, Journal of immunology.

Anti‐viral immune response of allogeneic irradiation bone marrow chimeras: cytotoxic T cell responsiveness depends upon H‐2 combination and infectious agent

R. Zinkernagel, T. Sado, A. Althage, 1984, European journal of immunology.

Search for Suppression of T Cells Specific for the Second Nonhost H-2 Haplotype in F1 → P Irradiation Bone Marrow Chimeras

R. Zinkernagel, A. Althage, 1979, The Journal of Immunology.

T cell development in CD8-/- mice. Thymic positive selection is biased toward the helper phenotype.

R. Zinkernagel, T. Mak, A. Oxenius, 1995, Journal of immunology.

INDICATIONS OF ACTIVE SUPPRESSION IN MOUSE CARRIERS OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS

R. Zinkernagel, P. Doherty, R. Zinkernagel, 1974 .

Activation or suppression of bactericidal activity of macrophages during a graft-versus-host reaction againstI-A andI-J-region differences, respectively

R. Zinkernagel, 2005, Immunogenetics.

Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4

R. Zinkernagel, M. Bachmann, R. Kühn, 1995, Journal of virology.

Immunosuppression by a noncytolytic virus via T cell mediated immunopathology. Implication for AIDS.

R. Zinkernagel, 1995, Advances in experimental medicine and biology.

Restriction specificities, alloreactivity, and allotolerance expressed by T cells from nude mice reconstituted with H-2-compatible or - incompatible thymus grafts

R. Zinkernagel, R. Welsh, E. Waterfield, 1980, The Journal of experimental medicine.

Living donor liver transplantation and tolerance: a potential strategy in cholangiocarcinoma.

R. Zinkernagel, P. Clavien, Z. Kadry, 2003, Transplantation.

TAP1‐independent loading of class I molecules by exogenous viral proteins

S. Tonegawa, H. Pircher, R. Zinkernagel, 1995, European journal of immunology.

Response: immunology taught by darwin.

R. Zinkernagel, 1996, Science.

Multiple immune abnormalities in tumor necrosis factor and lymphotoxin-alpha double-deficient mice.

R. Zinkernagel, B. Ryffel, M. Le Hir, 1996, International immunology.

Antagonistic Variant Virus Prevents Wild-type Virus-induced Lethal Immunopathology

R. Zinkernagel, L. Hunziker, H. Hengartner, 2002, Journal of Experimental Medicine.

Molecular analysis of the antigen receptor of virus‐specific cytotoxic T cells and identification of a new Vα family

H. Pircher, R. Zinkernagel, T. Mak, 1987 .

Identical Vβ T-cell receptor genes used in alloreactive cytotoxic and antigen plus I–A specific helper T cells

R. Zinkernagel, R. Joho, H. Hengartner, 1985, Nature.

T helper cell unresponsiveness: Rapid induction in antigen‐transgenic and reversion in non‐transgenic mice

R. Zinkernagel, M. Bachmann, U. Steinhoff, 1994, European journal of immunology.

Localization of T helper cell epitopes in the vesicular stomatitis virus: the nucleoprotein is responsible for serotype cross-reactive T help.

R. Zinkernagel, U. Steinhoff, D. Bishop, 1994, Viral immunology.

Antibodies against the two serotypes of vesicular stomatitis virus measured by enzyme-linked immunosorbent assay: immunodominance of serotype-specific determinants and induction of asymmetrically cross-reactive antibodies

R. Zinkernagel, H. Hengartner, S. Charan, 1987, Journal of virology.

Cross-reactive cytotoxic T cells to serologically distinct vesicular stomatitis virus.

R. Zinkernagel, K. Rosenthal, 1980, Journal of immunology.

Protective T Cell–Independent Antiviral Antibody Responses Are Dependent on Complement

R. Zinkernagel, H. Hengartner, M. Carroll, 1999, The Journal of experimental medicine.

Cellular Immune Response to Viruses and the Biological Role of Polymorphic Major Transplantation Antigens

R. Zinkernagel, 1979 .

Speculations on the role of major transplantation antigens in cell-mediated immunity against intracellular parasites.

R. Zinkernagel, R. Zinkernagel, 1978, Current topics in microbiology and immunology.

H-2 compatibility requirement for virus-specific T-cell-mediated cytolysis. Evaluation of the role of H-2I region and non-H-2 genes in regulating immune response

R. Zinkernagel, P. Doherty, R. Blanden, 1976, The Journal of experimental medicine.

H-2 compatibility requirement for virus-specific T-cell-mediated cytolysis. The H-2K structure involved is coded by a single cistron defined by H-2Kb mutant mice

R. Zinkernagel, 1976, The Journal of experimental medicine.

The 1995 Albert Lasker Medical Research Award. MHC-restricted T-cell recognition. The basis of immune surveillance.

R. Zinkernagel, 1995, JAMA.

Virus-specific proliferative T-cell responses: parameters and specificity.

R. Zinkernagel, G. Kreeb, 1980, Cellular immunology.

Neonatally tolerant mice fail to react against virus-infected tolerated cells

R. Zinkernagel, J. Klein, J. Streilein, 1977, Nature.

Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo

Rolf M. Zinkernagel, Hans Hengartner, Kurt Bürki, 1990, Nature.

Immune surveillance and AIDS progression

P. Klenerman, R. Zinkernagel, 1997, Current Biology.

Games that viruses play

R. Zinkernagel, H. Hengartner, 1991, Nature.

On the pathogenesis of perforin defects and related immunodeficiencies.

R. Zinkernagel, H. Hengartner, L. Moretta, 2000, Immunology today.

Decreased Tumor Surveillance in Perforin-deficie nt Mice By Maries E van den Broek,* David K~igi, Ferry Ossendorpfl Ren6 Toesfi SpirosVamvakas,~ Werner K. Lutz,~ Cornelis J.M. Melieffl

R. Zinkernagel, H. Hengartner, 1996 .

Perforin dependence of natural killer cell‐mediated tumor control in vivo

R. Zinkernagel, M. van den Broek, H. Hengartner, 1995, European journal of immunology.

Allogeneic β-islet cells correct diabetes and resist immune rejection

R. Zinkernagel, P. Aebischer, B. Thorens, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Peritoneal macrophages as target cells for measuring virus-specific T cell mediated cytotoxicity in vitro.

R. Zinkernagel, P. Doherty, R. M. Zinkernagel, 1975, Journal of immunological methods.

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

H. Pircher, R. Zinkernagel, B. Malissen, 1991, Cell.

On the Role of Dendritic Cells Versus Other Cells in Inducing Protective CD8+ T Cell Responses

R. Zinkernagel, 2014, Front. Immunol..

Responses to Cohn's Discussion on the Zinkernagel–Hengartner ‘Credo 2004’

R. Zinkernagel, H. Hengartner, 2005 .

Transgenic Animal Models for Virus‐Induced Autoimmune Diseases

R. Zinkernagel, B. Ludewig, H. Hengartner, 2000, Experimental physiology.

T cells causing immunological disease: immunopathology or autoimmunity?

R. Zinkernagel, H. Hengartner, 1992, Research in immunology.

Production of B cell stimulatory factor-2 and interferon gamma in the central nervous system during viral meningitis and encephalitis. Evaluation in a murine model infection and in patients

R. Zinkernagel, K. Frei, A. Meager, 1988, The Journal of experimental medicine.

CD4 1 T Cell Subsets during Virus Infection: Protective Capacity Depends on Effector Cytokine Secretion and on Migratory Capability

R. Zinkernagel, A. Oxenius, T. Junt, 2000 .

Reply to 'On the implications of polyclonal B cell activation'

R. Zinkernagel, A. Macpherson, L. Hunziker, 2003, Nature Immunology.

Antiviral immune responses in gene-targeted mice expressing the immunoglobulin heavy chain of virus-neutralizing antibodies

R. Zinkernagel, K. Fink, L. Hangartner, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Natural killer cells vs cytotoxic T cells in the peripheral blood of virus-infected mice.

R. Zinkernagel, L. Stitz, H. Hengartner, 1985, Journal of immunology.

Cytotoxic T cell lysis of target cells fused with liposomes containing influenza virus haemagglutinin and neuraminidase.

R. Zinkernagel, L. Stitz, H. Hengartner, 1985, The Journal of general virology.

A Btk transgene restores the antiviral TI‐2 antibody responses of xid mice in a dose‐dependent fashion

R. Zinkernagel, A. Satterthwaite, O. Witte, 1999, European journal of immunology.

Impaired immune and acute-phase responses in interleukin-6-deficient mice

R. Zinkernagel, H. Baumann, T. Kishimoto, 1994, Nature.

Absence of complement receptor type 3 and lymphocyte function antigen 1 causing deficient phagocyte and lymphocyte functions

R. Zinkernagel, V. Wahn, A. Böcker, 1988, European Journal of Pediatrics.

The role of antigen in maintaining T cell memory.

R. Zinkernagel, 1994, Developments in biological standardization.

The question of derepression ofH-2 specificities in virus-infected cells: Failure to detect specific alloreactive T cells after systemic virus infection or alloantigens detectable by alloreactive T cells on virus-infected target cells

R. Zinkernagel, A. Althage, B. Adler, 1977, Immunogenetics.

About the Discovery of MHC-restricted T Cell Recognition

R. Zinkernagel, 1995 .

[Transplantation antigens: biological function and role as disease determinants].

R. Zinkernagel, 1982, Die Naturwissenschaften.

Virus-specific T-cell-mediated cytotoxicity across the H–2 barrier to virus-altered alloantigen

R. Zinkernagel, 1976, Nature.

15 – Lymphocyte–Macrophage Interactions and Macrophage Activation in the Expression of Antimicrobial Immunity in Vivo

R. Zinkernagel, P. Doherty, R. Blanden, 1976 .

DOES THE APPARENT H-2 COMPATIBILITY REQUIREMENT FOR VIRUS-SPECIFIC T CELL-MEDIATED CYTOLYSIS REFLECT T CELL SPECIFICITY FOR “ALTERED SELF” OR PHYSIOLOGICAL INTERACTION MECHANISMS?

R. Zinkernagel, P. Doherty, 1976 .

Escape of thymocytes and mature T cells from clonal deletion due to limiting tolerogen expression levels.

R. Zinkernagel, P. Ohashi, H. Hengartner, 1994, Cellular immunology.

Detection of perforin and granzyme A mRNA in infiltrating cells during infection of mice with lymphocytic choriomeningitis virus

R. Zinkernagel, E. Podack, H. Hengartner, 1989, European journal of immunology.

Viral escape from the neutralizing antibody response: the lymphocytic choriomeningitis virus model

R. Zinkernagel, L. Hunziker, H. Hengartner, 2001, Immunogenetics.

Endogenous neosynthesis vs. cross-presentation of viral antigens for cytotoxic T cell priming

R. Zinkernagel, H. Hengartner, K. Bienz, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Kinetics of protective antibodies are determined by the viral surface antigen

R. Zinkernagel, T. Bächi, M. Whitt, 2004 .

Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytes choriomeningitis

R. Zinkernagel, P. Doherty, ROLF M. ZINKERNAGEL, 1974, Nature.

MHC-RESTRICTION AND DIFFERENTIATION OF T CELLS1

R. Zinkernagel, 1979 .

POSSIBLE FUNCTION OF H-2 CODED CELL-SURFACE MARKERS: H-2 STRUCTURES ARE RECEPTORS FOR DIFFERENTIATION SIGNALS

R. Zinkernagel, 1978 .

Specificity and development of cytotoxic thymus-derived lymphocytes in lymphocytic choriomeningitis.

R. Zinkernagel, P. Doherty, I. Ramshaw, 1974, Journal of immunology.

Protective antiviral cytotoxic T cell memory is most efficiently maintained by restimulation via dendritic cells.

R. Zinkernagel, B. Ludewig, R. Schwendener, 1999, Journal of immunology.

Restimulation Via Dendritic Cells Is Most Efficiently Maintained by Protective Antiviral Cytotoxic T Cell Memory

R. Zinkernagel, B. Ludewig, A. Schwendener, 1999 .

Major histocompatibility complex-linked susceptibility or resistance to disease caused by a noncytopathic virus varies with the disease parameter evaluated

R. Zinkernagel, H. Hengartner, T. Leist, 1989, The Journal of experimental medicine.

Induction of optimal anti‐viral neutralizing B cell responses by dendritic cells requires transport and release of virus particles in secondary lymphoid organs

R. Zinkernagel, B. Ludewig, H. Hengartner, 2000, European journal of immunology.

T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens

R. Zinkernagel, H. Macdonald, H. Hengartner, 1988, Nature.

Clonal deletion of self-reactive T cells in irradiation bone marrow chimeras and neonatally tolerant mice. Evidence for intercellular transfer of Mlsa

R. Zinkernagel, D. Speiser, H. Macdonald, 1989, The Journal of experimental medicine.

Inflammatory process in murine lymphocytic choriomeningitis is maximal in H-2K or H-2D compatible interactions.

R. Zinkernagel, P. Doherty, C. Parish, 1976, Journal of immunology.

No functional γ-chain transcripts detected in an alloreactive cytotoxic T-cell clone

R. Zinkernagel, R. Joho, H. Hengartner, 1986, Nature.

Specific immune lysis of paramyxovirus-infected cells by H-2-compatible thymus-derived lymphocytes.

R. Zinkernagel, P. Doherty, 1976, Immunology.

Functional role of type I and type II interferons in antiviral defense.

M Aguet, R M Zinkernagel, R. Zinkernagel, 1994, Science.

Virus-specific cytotoxic T cell-mediated lysis of lymphocytes in vitro and in vivo.

R. Zinkernagel, D. Speiser, H. Hengartner, 1993, Journal of immunology.

Role of an Intact Splenic Microarchitecture in Early Lymphocytic Choriomeningitis Virus Production

R. Zinkernagel, J. D. Di Santo, L. Hunziker, 2002, Journal of Virology.

Protection T Cell-Mediated Antiviral + for CD4 Qualitative and Quantitative Requirements

H. Pircher, R. Zinkernagel, U. Hoffmann‐Rohrer, 1999 .

Antiviral protection by vesicular stomatitis virus-specific antibodies in alpha/beta interferon receptor-deficient mice.

R. Zinkernagel, U. Steinhoff, M. Aguet, 1995, Journal of virology.

Characterization and immunological properties of influenza A virus nucleoprotein (NP): cell-associated NP isolated from infected cells or viral NP expressed by vaccinia recombinant virus do not confer protection.

E. Paoletti, R. Zinkernagel, L. Stitz, 1990, The Journal of general virology.

Exacerbation of experimental murine cutaneous leishmaniasis with CD4+ Leishmania major‐specific T cell lines or clones which secrete interferon‐γ and mediate parasite‐specific delayed‐type hypersensitivity

R. Zinkernagel, R. Titus, J. Louis, 1991, European journal of immunology.

Cellular Immune Recognition and the Biological Role of Major Transplantation Antigens

R. Zinkernagel, 1997, Bioscience reports.

On the immunocompetence of H-2 incompatible irradiation bone marrow chimeras.

R. Zinkernagel, R. Welsh, G. Callahan, 1980, Journal of immunology.

The Role of Specific T Cell Subpopulations in Murine Cutaneous Leishmaniasis

R. Zinkernagel, R. Titus, J. Louis, 1986 .

A monoclonal antibody against altered LFA‐1 induces proliferation and lymphokine release of cloned T cells

H. Pircher, R. Zinkernagel, M. Aguet, 1986, European journal of immunology.

HLA and H-2

R. Zinkernagel, 1979, Nature.

Anti-Listeria monocytogenes immunity in μ-suppressed mice: a comparison of treatment with conventional hyperimmune rabbit anti-mouse IgM and affinity-purified, monoclonal rat anti-mouse IgM

R. Zinkernagel, H. Bazin, H. Hengartner, 2004, Medical Microbiology and Immunology.

Virus neutralization by germ-line vs. hypermutated antibodies.

R. Zinkernagel, A. Oxenius, H. Hengartner, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Efficient T cell repertoire selection in tetraparental chimeric mice independent of thymic epithelial MHC

R. Zinkernagel, T. Rülicke, D. Speiser, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Selection of restriction specificities of virus-specific cytotoxic T cells in the thymus: no evidence for a crucial role of antigen- presenting cells

R. Zinkernagel, 1982, The Journal of experimental medicine.

Rapid Peptide Turnover and Inefficient Presentation of Exogenous Antigen Critically Limit the Activation of Self-Reactive CTL by Dendritic Cells1

R. Zinkernagel, C. Melief, B. Ludewig, 2001, The Journal of Immunology.

Susceptibility to murine lymphocytic choriomeningitis maps to class I MHC genes—a model for MHC/disease associations

R. Zinkernagel, H. Hengartner, C. Pfau, 1985, Nature.

IgA production without mu or delta chain expression in developing B cells.

R. Zinkernagel, G. Dougan, K. McCoy, 2001, Nature immunology.

Virus-Induced Acquired Immunosuppression by T-Cell-Mediated Immunopathology and Vaccine Strategies

R. Zinkernagel, 1993 .

Immune response in mice that lack the interferon-gamma receptor.

R. Zinkernagel, J. Vilček, S. Huang, 1993, Science.

Immunogenicity of a viral model vaccine after different inactivation procedures

R. Zinkernagel, M. Bachmann, H. Hengartner, 1994, Medical Microbiology and Immunology.

Neutralizing antiviral B cell responses.

R. Zinkernagel, M. Bachmann, 1997, Annual review of immunology.

Immunology Taught by Viruses

Rolf M. Zinkernagel, R. Zinkernagel, 1996, Science.

H-2 compatibility is required for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus

R. Zinkernagel, P. Doherty, R. M. Zinkernagel, 1975, The Journal of experimental medicine.

A platelet-mediated system for shuttling blood-borne bacteria to CD8α+ dendritic cells depends on glycoprotein GPIb and complement C3

M. Neuenhahn, D. Busch, R. Zinkernagel, 2011, Nature Immunology.

MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness.

R M Zinkernagel, R. Zinkernagel, P. Doherty, 1979, Advances in immunology.

A crucial role for B cells in neuroinvasive scrapie

A. Aguzzi, R. Zinkernagel, A. Raeber, 1997, Nature.

Effect of cyclosporin A on immunity to Listeria monocytogenes

R. Zinkernagel, H. Hengartner, A. Cerny, 1986, Infection and immunity.

Suppression by cyclosporin A of murine T-cell-mediated immunity against viruses in vivo and in vitro.

R. Zinkernagel, H. Hengartner, A. Cerny, 1985, Cellular immunology.

On natural and artificial vaccinations.

R. Zinkernagel, 2003, Annual review of immunology.

Natural antibodies and complement link innate and acquired immunity.

R M Zinkernagel, R. Zinkernagel, A. Ochsenbein, 2000, Immunology today.

Hypercholesterolemia Exacerbates Virus-Induced Immunopathologic Liver Disease Via Suppression of Antiviral Cytotoxic T Cell Responses1

R. Zinkernagel, B. Ludewig, H. Hengartner, 2001, The Journal of Immunology.

The thymus: Its influence on recognition of “self major histocompatibility antigens” by T cells and consequences for reconstitution of immunodeficiency

R. Zinkernagel, 1978, Springer Seminars in Immunopathology.

Cytotoxic T cells learn specificity for self H–2 during differentiation in the thymus

R. Zinkernagel, J. Klein, G. Callahan, 1978, Nature.

Major transplantation antigens, viruses, and specificity of surveillance T cells.

R. Zinkernagel, P. Doherty, R. M. Zinkernagel, 1977, Contemporary topics in immunobiology.

H-2 compatability requirement for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. Different cytotoxic T- cell specificities are associated with structures coded for in H-2K or H-2D;

R. Zinkernagel, P. Doherty, 1975, The Journal of experimental medicine.

Association of disease susceptibility to major histocompatibility antigens.

R. Zinkernagel, 1979, Transplantation proceedings.

A comparison of T cell memory against the same antigen induced by virus versus intracellular bacteria.

P. Klenerman, R. Zinkernagel, J. Miller, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Early appearance of sensitized lymphocytes in mice infected with Listeria monocytogenes.

R. Zinkernagel, R. Blanden, R. E. Langman, 1974, Journal of immunology.

Control of early viral and bacterial distribution and disease by natural antibodies.

R. Zinkernagel, T. Fehr, F. Brombacher, 1999, Science.

On cross‐priming of MHC class I‐specific CTL: rule or exception?

R. Zinkernagel, 2002, European journal of immunology.

T cell-independent type I antibody response against B cell epitopes expressed repetitively on recombinant virus particles.

R. Zinkernagel, T. Fehr, P. Pumpens, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Skin test to assess virus-specific cytotoxic T-cell activity.

R. Zinkernagel, T. Kündig, H. Hengartner, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Crucial role of marginal zone macrophages and marginal zone metallophils in the clearance of lymphocytic choriomeningitis virus infection

R. Zinkernagel, R. Schwendener, H. Hengartner, 1997, European journal of immunology.

T and B cell Tolerance and Responses to Viral Antigens in Transgenic Mice: Implications for the Pathogenesis of Autoimmune versus Immunopathological Disease

H. Pircher, R. Zinkernagel, T. Mak, 1991, Immunological reviews.

Influence of one virus infection on a second concurrent primary in vivo antiviral cytotoxic T-cell response

R. Zinkernagel, M. Brenan, 1983, Infection and immunity.

Persistence of vesicular stomatitis virus in cloned interleukin-2-dependent natural killer cell lines

R. Zinkernagel, K. Rosenthal, H. Hengartner, 1986, Journal of virology.

Neutralizing antiviral antibody responses

R. Zinkernagel, K. McCoy, T. Fehr, 2001, Advances in Immunology.

Exhaustion of cytotoxic T cells during adoptive immunotherapy of virus carrier mice can be prevented by B cells or CD4+ T cells

Lukas Hunziker, Stephan Ehl, P. Klenerman, 2002, European journal of immunology.

A critical role for neutralizing-antibody-producing B cells, CD4(+) T cells, and interferons in persistent and acute infections of mice with lymphocytic choriomeningitis virus: implications for adoptive immunotherapy of virus carriers.

R M Zinkernagel, H Hengartner, R. Zinkernagel, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Models for recognition of virally modified cells by immune thymus-derived lymphocytes

R. Zinkernagel, G. Trinchieri, P. Doherty, 1976, Immunogenetics.

Cell-mediated immunity to hepatitis-associated antigen (HAA) demonstrated by leucocyte migration test during and after acute B hepatitis.

R. Zinkernagel, P. Frei, P. Erard, 1973, Biomedicine / [publiee pour l'A.A.I.C.I.G.].

Qualitative and quantitative requirements for CD4+ T cell-mediated antiviral protection.

H. Pircher, R. Zinkernagel, U. Hoffmann‐Rohrer, 1999, Journal of immunology.

On the Key Role of Secondary Lymphoid Organs in Antiviral Immune Responses Studied in Alymphoplastic (aly/aly) and Spleenless (Hox11− /−) Mutant Mice

S. Korsmeyer, R. Zinkernagel, C. Roberts, 1997, The Journal of experimental medicine.

On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases

R. Zinkernagel, K. Frei, A. Fontana, 1989, European journal of immunology.

The influence of antigen organization on B cell responsiveness.

R. Zinkernagel, T. Kündig, M. Bachmann, 1993, Science.

B cells are required for induction of T cell abnormalities in a murine retrovirus-induced immunodeficiency syndrome

R. Zinkernagel, R. Hardy, A. Cerny, 1990, The Journal of experimental medicine.

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

Hans Hengartner, Kurt Bürki, R. Zinkernagel, 1994, Nature.

Role of Repetitive Antigen Patterns for Induction of Antibodies Against Antibodies

R. Zinkernagel, T. Fehr, M. Bachmann, 1997, The Journal of experimental medicine.

Immunosuppression in mice by lymphocytic choriomeningitis virus infection: time dependence during primary and absence of effects on secondary antibody responses.

R. Zinkernagel, H. Hengartner, E. Rüedi, 1990, Cellular immunology.

Suppression of B cell development and antibody responses in mice with polyclonal rabbit and monoclonal rat anti-IgM antibodies. I. Characterization of the suppressed state.

R. Zinkernagel, C. Heusser, H. Hengartner, 1985, Experimental cell biology.

Suppressive effects of B-lactam-antibiotics on in vitro generation of cytotoxic T-cells.

R. Zinkernagel, K. Neftel, A. Cerny, 1986, International journal of immunopharmacology.

Localization dose and time of antigens determine immune reactivity.

R M Zinkernagel, R. Zinkernagel, R. M. Zinkernagel, 2000, Seminars in immunology.

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

H. Pircher, R. Zinkernagel, H. Hengartner, 1989, Nature.

Production of B Cell Stimulatory Factor-2 and Interferon Y in the Central Nervous System during Viral Meningitis and Encephalitis Evaluation in a Murine Model Infection and in Patients Brief Definitive Report

R. Zinkernagel, K. Frei, A. Fontana, 1988 .

Evidence for a differential avidity model of T cell selection in the thymus

S. Tonegawa, H. Pircher, R. Zinkernagel, 1994, Cell.

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

Rolf M. Zinkernagel, Hanspeter Pircher, H. Pircher, 1993, Nature.

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

Rolf M. Zinkernagel, R. Zinkernagel, F. Lechner, 1993, Nature.

Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo.

R. Zinkernagel, H. Hengartner, B. Ledermann, 1996, Annual review of immunology.

T‐Cell Reactivity and Tolerance to Mlsa‐Encoded Antigens

H. Pircher, R. Zinkernagel, H. Macdonald, 1989, Immunological reviews.

T‐Cell Lineages, Repertoire Selection and Tolerance Induction

R. Zinkernagel, H. Macdonald, J. Louis, 1988, Immunological reviews.

Inhibition of HSV-1 and vaccinia virus replication by cephalosporin derivatives.

R. Zinkernagel, K. Neftel, P. Cottagnoud, 1988, Antiviral research.

On observing and analyzing disease versus signals

R. Zinkernagel, 2007, Nature Immunology.

Immune Defence in Mice Lacking Type I and/or Type II Interferon Receptors

R. Zinkernagel, M. Aguet, Sui Huang, 1995, Immunological reviews.

Viral escape and the failure of cellular immune responses.

P. Klenerman, R. Zinkernagel, F. Lechner, 2000, Science.

Targeted Inactivation of the Tetraspanin CD37 Impairs T-Cell-Dependent B-Cell Response under Suboptimal Costimulatory Conditions

M. Wright, R. Zinkernagel, K. Knobeloch, 2000, Molecular and Cellular Biology.

Marginal Zone Macrophages and Immune Responses Against Viruses1

R. Zinkernagel, H. Hengartner, B. Odermatt, 2002, The Journal of Immunology.

Protectionof Neonatal Mucosal Antibody

R. Zinkernagel, A. Macpherson, K. Bürki, 2013 .

Antibody Protection Mechanisms of Neonatal Mucosal

Bernhard Odermatt, Rolf M. Zinkernagel, Alain Lamarre, 2010 .

Mechanisms of Neonatal Mucosal Antibody Protection1

R. Zinkernagel, A. Macpherson, J. Urban, 2006, The Journal of Immunology.

Complement facilitates early prion pathogenesis

I. Xenarios, A. Aguzzi, R. Zinkernagel, 2001, Nature Medicine.

Major histocompatibility complex – dependent T cell epitopes of lymphocytic choriomeningitis virus nucleoprotein and their protective capacity against viral disease

R. Zinkernagel, F. Cardinaux, H. Hengartner, 1989, European journal of immunology.

Passive oral immunization with bovine immunoglobulins: EnteropathogenicEscherichia coli from infants and bovine anti-E. coli lactoserum assayed in the rabbit ileal loop model

R. Zinkernagel, A. Colombini, 1975, Medical Microbiology and Immunology.

Peptide‐induced T cell receptor down‐regulation on naive T cells predicts agonist/partial agonist properties and strictly correlates with T cell activation

R. Zinkernagel, A. Oxenius, D. Speiser, 1997, European journal of immunology.

Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates.

R M Zinkernagel, H Hengartner, R. Zinkernagel, 1991, Journal of virological methods.

Anti‐viral protection and prevention of lymphocytic choriomeningitis or of the local footpad swelling reaction in mice by immunization with vaccinia‐recombinant virus expressing LCMV‐WE nucleoprotein or glycoprotein

R. Zinkernagel, D. Bishop, H. Hengartner, 1989, European journal of immunology.

Microchimerism maintains deletion of the donor cell-specific CD8+ T cell repertoire.

R. Zinkernagel, B. Ludewig, H. Hengartner, 2005, The Journal of clinical investigation.

Long‐lasting immunity by early infection of maternal‐antibody‐protected infants

R. Zinkernagel, M. Niemiałtowski, M. Krzyżowska, 2009, European journal of immunology.

Decreased tumor surveillance in perforin-deficient mice

R. Zinkernagel, C. Melief, H. Hengartner, 1996, The Journal of experimental medicine.

Immune responses in interleukin-2-deficient mice.

R. Zinkernagel, T. Kündig, M. Bachmann, 1993, Science.

Prevention of Scrapie Pathogenesis by Transgenic Expression of Anti-Prion Protein Antibodies

F. Heppner, A. Aguzzi, R. Zinkernagel, 2001, Science.

Immunopathology or Organ‐Specific Autoimmunity as a Consequence of Virus Infection

R. Zinkernagel, M. Bachmann, H. Hengartner, 1996, Immunological reviews.

Antiviral Protection and Germinal Center Formation, But Impaired B Cell Memory in the Absence of CD19

R. Zinkernagel, K. Rajewsky, J. Roes, 1998, The Journal of experimental medicine.

PROTECTIVE ANTIBODY RESPONSES AGAINST VIRUSES

R. Zinkernagel, 1997 .

Immunological memory ≠ protective immunity

R. Zinkernagel, 2012, Cellular and Molecular Life Sciences.

Immunology and immunity against infection: General rules

R. Zinkernagel, 2005 .

On Immunity Against Infections and Vaccines: Credo 2004

R. Zinkernagel, R. M. Zinkernagel, Rolf M. Zinkernagel, 2004, Scandinavian journal of immunology.

Do thymically and strictly extrathymically developing T cells generate similar immune responses?

R. Zinkernagel, C. Perreault, M. Martinic, 2004, Blood.

Antiinfection Immunity and Autoimmunity

R. Zinkernagel, 2002, Annals of the New York Academy of Sciences.

PDFlib PLOP: PDF Linearization, Optimization, Protection Page inserted by evaluation version

R. Zinkernagel, 2002 .

Dendritic cells in autoimmune diseases.

R. Zinkernagel, T. Junt, B. Ludewig, 2001, Current opinion in immunology.

Regulation of the Immune Response by Antigen

R. Zinkernagel, H. Hengartner, 2001, Science.

Immunity against solid tumors?

R. Zinkernagel, 2001, International journal of cancer.

What is missing in immunology to understand immunity?

Rolf M. Zinkernagel, R. Zinkernagel, 2000, Nature Immunology.

In vivo antigen loading and activation of dendritic cells via a liposomal peptide vaccine mediates protective antiviral and anti-tumour immunity.

R. Zinkernagel, B. Ludewig, R. Schwendener, 2000, Vaccine.

T-independent activation of B cells by vesicular stomatitis virus: no evidence for the need of a second signal.

R. Zinkernagel, T. Fehr, M. Bachmann, 1996, Cellular immunology.

Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors

R. Zinkernagel, M. van den Broek, S. Huang, 1995, Journal of virology.

Free recirculation of memory B cells versus antigen-dependent differentiation to antibody-forming cells.

R. Zinkernagel, T. Kündig, M. Bachmann, 1994, Journal of immunology.

Analysis of the kinetics of antiviral memory T help in vivo: characterization of short‐lived cross‐reactive T help

R. Zinkernagel, S. Charan, H. Roost, 1990, European journal of immunology.

Susceptibility to lymphocytic choriomeningitis virus isolates correlates directly with early and high cytotoxic T cell activity, as well as with footpad swelling reaction, and all three are regulated by H-2D

R. Zinkernagel, H. Hengartner, T. Leist, 1985, The Journal of experimental medicine.

Maternal antibodies, childhood infections, and autoimmune diseases.

R. Zinkernagel, 2001, The New England journal of medicine.

Characterization of an Lyt-2+ alloreactive cytotoxic T cell clone specific for H-2Db that cross-reacts with I-Ek.

R. Zinkernagel, M. Schilham, R. Benner, 1986, Journal of immunology.

On the role of thymic epithelium vs. bone marrow-derived cells in repertoire selection of T cells.

R M Zinkernagel, R. Zinkernagel, A Althage, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Antigen localisation regulates immune responses in a dose‐ and time‐dependent fashion: a geographical view of immune reactivity

Hans Hengartner, Stephan Ehl, Peter Aichele, 1997, Immunological reviews.

Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection.

R. Zinkernagel, K. McCoy, A. Macpherson, 2008, Cell host & microbe.

Identification and characterization of a novel antigen from the nematode Nippostrongylus brasiliensis recognized by specific IgE

R. Zinkernagel, K. McCoy, B. Ludewig, 2007, European journal of immunology.

Hypergammaglobulinemia and autoantibody induction mechanisms in viral infections

R. Zinkernagel, A. Macpherson, L. Hunziker, 2003, Nature Immunology.

General and specific immunosuppression caused by antiviral T‐cell responses

P. Klenerman, R. Zinkernagel, M. Battegay, 1999, Immunological reviews.

Antigen localization and migration in immunity and tolerance.

T. Starzl, R. Zinkernagel, T. Starzl, 1998, The New England journal of medicine.

Inhibition of hapten‐specific cytotoxic T cell recognition by monoclonal anti‐hapten antibodies

H. Pircher, R. Zinkernagel, H. Hengartner, 1985, European journal of immunology.

H-2-associated specificity of virus-immune cytotoxic T cells fromH-2 mutant and wild-type mice: M523 (H-2Kka) and M505(H-2Kbd) do, M504 (H-2Dda) and M506(H-2Kfa) do not crossreact with wild-typeH-2K orH-2D

R. Zinkernagel, J. Klein, 1977, Immunogenetics.

Antiviral T cell competence and restriction specificity of mixed allogeneic (P1 + P2----P1) irradiation chimeras.

R. Zinkernagel, D. Sachs, M. Sykes, 1989, Cellular immunology.

Impairment of Cd4+ T Cell Responses during Chronic Virus Infection Prevents Neutralizing Antibody Responses against Virus Escape Mutants

P. Klenerman, R. Zinkernagel, L. Hunziker, 2001, The Journal of experimental medicine.

Comparison of activation versus induction of unresponsiveness of virus-specific CD4+ and CD8+ T cells upon acute versus persistent viral infection.

R. Zinkernagel, A. Oxenius, H. Hengartner, 1998, Immunity.

Public versus personal serotypes of a viral quasispecies

R. Zinkernagel, L. Hunziker, H. Hengartner, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Identification of an N-Terminal Trimeric Coiled-Coil Core within Arenavirus Glycoprotein 2 Permits Assignment to Class I Viral Fusion Proteins

J. Weber, R. Zinkernagel, A. Wepf, 2006, Journal of Virology.

The influence of virus structure on antibody responses and virus serotype formation.

R. Zinkernagel, M. Bachmann, Martin F. Bachmann, 1996, Immunology today.

Characterization of T-helper epitopes of the glycoprotein of vesicular stomatitis virus

R. Zinkernagel, L. Adorini, K. Wiesmüller, 1994, Journal of virology.

Induction and Exhaustion of Lymphocytic Choriomeningitis Virus–specific Cytotoxic T Lymphocytes Visualized Using Soluble Tetrameric Major Histocompatibility Complex Class I–Peptide Complexes

R. Zinkernagel, T. Elliott, A. Plückthun, 1998, The Journal of experimental medicine.

Cellular Immune Recognition and the Biological Role of Major Transplantation Antigens

R. Zinkernagel, 1997, Scandinavian journal of immunology.

Major histocompatibility complex binding and T cell recognition of a viral nonapeptide containing a minimal tetrapeptide

R. Zinkernagel, H. Hengartner, P. Aichele, 1991, European journal of immunology.

Antiviral cytotoxic T cell response induced by in vivo priming with a free synthetic peptide

R. Zinkernagel, H. Hengartner, P. Aichele, 1990, The Journal of experimental medicine.

Antiviral T-cell memory?

R. Zinkernagel, 1990, Current topics in microbiology and immunology.

Virus-induced Transient Bone Marrow Aplasia: Major Role of Interferon-α/β during Acute Infection with the Noncytopathic Lymphocytic Choriomeningitis Virus

R. Zinkernagel, J. Fehr, H. Hengartner, 1997, The Journal of experimental medicine.

On differences between immunity and immunological memory.

R. Zinkernagel, Rolf M Zinkernagel, 2002, Current opinion in immunology.

Brief Definitive Report MONOCLONAL ANTIBODIES AGAINST VIRAL DETERMINANTS ARE NOT RESTRICTED TO THE K/D END OF THE MAJOR HISTOCOMPATIBILITY COMPLEX BY BERNHARD PESTALOZZI, * LOTHAR STITZ, $ AND

R. Zinkernagel, L. Stitz, B. Pestalozzi, 2022 .

A lymphocytic choriomeningitis virus glycoprotein variant that is retained in the endoplasmic reticulum efficiently cross-primes CD8+ T cell responses

J. Weber, R. Zinkernagel, Katharina Quirin, 2007, Proceedings of the National Academy of Sciences.

Cell-mediated immunity to vesicular stomatitis virus infections in mice.

J. Holland, R. Zinkernagel, B. Adler, 1978, Experimental cell biology.

Resistance of lymphocytic choriomeningitis virus to alpha/beta interferon and to gamma interferon

R. Zinkernagel, M. Battegay, D. Moskophidis, 1994, Journal of virology.

IL-4 and IL-10 Antagonize IL-12-Mediated Protection Against Acute Vaccinia Virus Infection with a Limited Role of IFN-γ and Nitric Oxide Synthetase 21

R. Zinkernagel, M. van den Broek, M. Bachmann, 2000, The Journal of Immunology.

Effector T‐Cell Induction and T‐Cell Memory versus Peripheral Deletion of T Cells

H. Pircher, R. Zinkernagel, D. Moskophidis, 1993, Immunological reviews.

Additive Effect of Neutralizing Antibody and Antiviral Drug Treatment in Preventing Virus Escape and Persistence

P. Klenerman, R. Zinkernagel, H. Hengartner, 2000, Journal of Virology.

Antivirally protective cytotoxic T cell memory to lymphocytic choriomeningitis virus is governed by persisting antigen

R. Zinkernagel, T. Kündig, H. Hengartner, 1992, The Journal of experimental medicine.

Extralymphatic virus sanctuaries as a consequence of potent T-cell activation

M. Hersberger, R. Zinkernagel, K. Fink, 2007, Nature Medicine.

Immunization with recombinant protein: conditions for cytotoxic T cell and/or antibody induction

R. Zinkernagel, M. Bachmann, H. Hengartner, 1994, Medical Microbiology and Immunology.

A functional and kinetic comparison of antiviral effector and memory cytotoxic T lymphocyte populations in vivo and in vitro

P. Klenerman, R. Zinkernagel, S. Ehl, 1997, European journal of immunology.

Protective long-term antibody memory by antigen-driven and T help-dependent differentiation of long-lived memory B cells to short-lived plasma cells independent of secondary lymphoid organs.

R. Zinkernagel, H. Hengartner, S. Sierro, 2000, Proceedings of the National Academy of Sciences of the United States of America.

CD4+ T-cell–epitope escape mutant virus selected in vivo

R. Zinkernagel, A. Oxenius, L. Hunziker, 2001, Nature Medicine.

Low responsiveness to Dk or Db plus vaccinia virus or to Kk plus lymphocytic choriomeningitis virus assessed by availability of D or K products.

R. Zinkernagel, G. Callahan, 2008, Tissue antigens.

The role of antibody concentration and avidity in antiviral protection.

M Aguet, R M Zinkernagel, H Hengartner, 1997, Science.

Protective ‘immunity’ by pre‐existent neutralizing antibody titers and preactivated T cells but not by so‐called ‘immunological memory’

R. Zinkernagel, H. Hengartner, 2006, Immunological reviews.

In vitro selection of lymphocytic choriomeningitis virus escape mutants by cytotoxic T lymphocytes.

R. Zinkernagel, D. Moskophidis, H. Hengartner, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Direct quantitation of rapid elimination of viral antigen‐positive lymphocytes by antiviral CD8+ T cells in vivo

Dominik Wodarz, Hans Hengartner, Stephan Ehl, 2000, European journal of immunology.

The roles of perforin‐ and Fas‐dependent cytotoxicity in protection against cytopathic and noncytopathic viruses

R. Zinkernagel, H. Hengartner, B. Ledermann, 1995, European journal of immunology.

Non‐tolerant B cells cause autoimmunity in anti‐CD8 IgG2a‐transgenic mice

R. Zinkernagel, M. Battegay, H. Eibel, 1996, European journal of immunology.

Crucial Role of Interferon Consensus Sequence Binding Protein, but neither of Interferon Regulatory Factor 1 nor of Nitric Oxide Synthesis for Protection Against Murine Listeriosis

R. Zinkernagel, T. Mak, T. Fehr, 1997, The Journal of experimental medicine.

Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration

S. Akira, A. Aguzzi, R. Zinkernagel, 2004, Nature Medicine.

Peptide antigen treatment of naive and virus-immune mice: antigen-specific tolerance versus immunopathology.

R M Zinkernagel, H Hengartner, H. Pircher, 1997, Immunity.

Induction of diabetes is influenced by the infectious virus and local expression of MHC class I and tumor necrosis factor-alpha.

H. Pircher, R. Zinkernagel, P. Ohashi, 1993, Journal of immunology.

Discrepancy between in vitro measurable and in vivo virus neutralizing cytotoxic T cell reactivities. Low T cell receptor specificity and avidity sufficient for in vitro proliferation or cytotoxicity to peptide-coated target cells but not for in vivo protection.

R. Zinkernagel, D. Speiser, H. Hengartner, 1992, Journal of immunology.

Vaccination for disease.

R. Zinkernagel, H. Hengartner, S. Oehen, 1991, Science.

Virus‐specific major MHC class II‐restricted TCR‐transgenic mice: effects on humoral and cellular immune responses after viral infection

R. Zinkernagel, A. Oxenius, M. Bachmann, 1998, European journal of immunology.

Presentation of endogenous viral proteins in association with major histocompatibility complex class II: On the role of intracellular compartmentalization, invariant chain and the TAP transporter system

S. Tonegawa, R. Zinkernagel, A. Oxenius, 1995, European journal of immunology.

Maintenance of memory CTL responses by T helper cells and CD40‐CD40 ligand: antibodies provide the key

R. Zinkernagel, T. Storni, M. Bachmann, 2004, European journal of immunology.

Cutting Edge Commentary: Immune Responses in the Absence of Costimulation: Viruses Know the Trick

R. Zinkernagel, A. Oxenius, M. Bachmann, 1998, The Journal of Immunology.

Visualization, characterization, and turnover of CD8+ memory T cells in virus-infected hosts

H. Pircher, R. Zinkernagel, C. Blaser, 1996, The Journal of experimental medicine.

The discovery of MHC restriction.

R. Zinkernagel, P. Doherty, R. M. Zinkernagel, 1997, Immunology today.

Class II major histocompatibility complex‐restricted T cell function in CD4‐deficient mice

R. Zinkernagel, T. Mak, T. Kündig, 1994, European journal of immunology.

How to escape immune surveillance?

R. Zinkernagel, 2004, Springer Seminars in Immunopathology.

Immunology and immunity studied with viruses.

R. Zinkernagel, 2007, Ciba Foundation symposium.

Secondary Rearrangements and Hypermutation Generate Sufficient B Cell Diversity to Mount Protective Antiviral Immunoglobulin Responses

R. Zinkernagel, M. Wabl, M. Cascalho, 1999, The Journal of experimental medicine.

Thymocyte Selection and Peripheral Tolerance Using the Lymphocytic Choriomeningitis Virus as a Model Antigen

H. Pircher, R. Zinkernagel, M. Battegay, 1994 .

On the role of viruses in the evolution of immune responses.

R. Zinkernagel, L. Stitz, H. Hengartner, 1985, British medical bulletin.

H-2 restriction of virus-specific T-cell-mediated effector functions in vivo. II. Adoptive transfer of delayed-type hypersensitivity to murine lymphocytic choriomeningits virus is restriced by the K and D region of H-2

R. Zinkernagel, 1976, The Journal of experimental medicine.

for CD4+ T Cell-Mediated Antiviral Qualitative and Quantitative Requirements

Rolf M. Zinkernagel, Burkhard Ludewig, Giulia Freer, 2013 .

Cd4+ T Cell Subsets during Virus Infection

R. Zinkernagel, A. Oxenius, T. Junt, 2000, The Journal of experimental medicine.

Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease

S. Akira, R. Zinkernagel, T. Junt, 2005, Nature Medicine.

IgA production without μ or δ chain expression in developing B cells

R. Zinkernagel, G. Dougan, K. McCoy, 2001, Nature Immunology.

Effects of cyclosporin A on humoral immune response and resistance against vesicular stomatitis virus in mice

R. Zinkernagel, H. Hengartner, A. Cerny, 1986, Journal of virology.

MHC Restriction and Cytotoxic T Lymphocytes

R. Zinkernagel, P. Doherty, 1984 .

Lactate dehydrogenase-elevating virus (LDV): lifelong coexistence of virus and LDV-specific immunity.

R. Zinkernagel, M. van den Broek, H. Hengartner, 1997, Journal of immunology.

PrP expression in B lymphocytes is not required for prion neuroinvasion

A. Aguzzi, R. Zinkernagel, A. Raeber, 1998, Nature Medicine.

Are HIV-specific CTL responses salutary or pathogenic?

R. Zinkernagel, 1995, Current opinion in immunology.

Suppression of virus-specific antibody production by CD8+ class I-restricted antiviral cytotoxic T cells in vivo

H. Pircher, R. Zinkernagel, D. Moskophidis, 1992, Journal of virology.

Immunity, immunopathology and vaccines against HIV?

R. Zinkernagel, 2002, Vaccine.

Nitric Oxide Synthetase 2 and γ Infection with a Limited Role of IFN-Protection Against Acute Vaccinia Virus IL-4 and IL-10 Antagonize IL-12-Mediated and

R. Zinkernagel, M. Bachmann, M. Kopf, 1999 .

Early type I interferon‐mediated signals on B cells specifically enhance antiviral humoral responses

S. Akira, R. Zinkernagel, T. Junt, 2006, European journal of immunology.

Immunity to viruses in B cell‐deficient mice: Influence of antibodies on virus persistence and on T cell memory

Klaus Rajewsky, Peter Aichele, R. Zinkernagel, 1996, European journal of immunology.

An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses.

R M Zinkernagel, P. Klenerman, R. Zinkernagel, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Induction of long-lived germinal centers associated with persisting antigen after viral infection

R. Zinkernagel, M. Bachmann, H. Hengartner, 1996, The Journal of experimental medicine.

T-cell-mediated immunopathology versus direct cytolysis by virus: implications for HIV and AIDS.

R. Zinkernagel, H. Hengartner, H. Hengartner, 1994, Immunology today.

Arterial inflammation and atherosclerosis.

R. Zinkernagel, B. Ludewig, H. Hengartner, 2002, Trends in cardiovascular medicine.

Cytotoxic T Cell Responses Disease Via Suppression of Antiviral Virus-Induced Immunopathologic Liver Hypercholesterolemia Exacerbates

R. Zinkernagel, B. Ludewig, H. Hengartner, 2001 .

Linking immune-mediated arterial inflammation and cholesterol-induced atherosclerosis in a transgenic mouse model.

M. Kurrer, R. Zinkernagel, B. Ludewig, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Preferential positive selection of Vα2+CD8+ T cells in mouse strains expressing both H‐2k and T cell receptor Vαa haplotypes: determination with a Vα2‐specific monoclonal antibody

H. Pircher, R. Zinkernagel, D. Speiser, 1992, European journal of immunology.

Peptides control the gain and loss of allele specificity by mutated MHC class I molecules.

R. Zinkernagel, U. Koszinowski, D. Kyburz, 1995, Journal of immunology.

Protection against immunopathological consequences of a viral infection by activated but not resting cytotoxic T cells: T cell memory without "memory T cells"?

R. Zinkernagel, T. Kündig, M. Bachmann, 1997, Proceedings of the National Academy of Sciences of the United States of America.

On T Cell Memory: Arguments for Antigen Dependence

H. Pircher, R. Zinkernagel, M. Bachmann, 1996, Immunological reviews.

Specific cytotoxic T cells eliminate B cells producing virus-neutralizing antibodies [corrected].

R M Zinkernagel, H Hengartner, R. Zinkernagel, 1996, Nature.

Impairment and delay of neutralizing antiviral antibody responses by virus-specific cytotoxic T cells.

R M Zinkernagel, H Hengartner, R. Zinkernagel, 1993, Journal of immunology.

Uncertainties − discrepancies in immunology

R. Zinkernagel, Rolf M. Zinkernagel, 2002, Immunological reviews.

Search for suppression of T cells specific for the second nonhost H-2 haplotype in F1 leads to P irradiation bone marrow chimeras.

R. Zinkernagel, A. Althage, 1979, Journal of Immunology.

Inverse correlation between IL‐7 receptor expression and CD8 T cell exhaustion during persistent antigen stimulation

Hans Hengartner, Mike Recher, R. Zinkernagel, 2005, European journal of immunology.

Induction of Protective Cytotoxic T Cell Responses in the Presence of High Titers of Virus-neutralizing Antibodies: Implications for Passive and Active Immunization

R. Zinkernagel, H. Hengartner, C. Zimmermann, 1998, The Journal of experimental medicine.

Induction of protective cytotoxic T cells with viral proteins

R. Zinkernagel, T. Kündig, M. Bachmann, 1994, European journal of immunology.

A protective cytotoxic T cell response to a subdominant epitope is influenced by the stability of the MHC class I/peptide complex and the overall spectrum of viral peptides generated within infected cells

Hans Hengartner, H. Rammensee, R. Zinkernagel, 1998, European journal of immunology.

On ‘reactivity’ versus ‘tolerance’

R. Zinkernagel, 2004, Immunology and cell biology.

UNDERSTANDING MICROBIAL PATHOGENESIS AS A BASIS FOR VACCINE DESIGN

R. Zinkernagel, 2003 .

Part C - Immunological Memory and Vaccines against Acute Cytopathic and Noncytopathic Infections

R. Zinkernagel, 2003 .

Strictly transporter of antigen presentation (TAP)-dependent presentation of an immunodominant cytotoxic T lymphocyte epitope in the signal sequence of a virus protein

H. Pircher, R. Zinkernagel, J. Hombach, 1995, The Journal of experimental medicine.

Vaccination with a synthetic peptide modulates lymphocytic choriomeningitis virus-mediated immunopathology

R. Zinkernagel, M. Battegay, H. Hengartner, 1992, Journal of virology.

Response to 'Lack of IgA in Cμ-deficient patients'

R. Zinkernagel, A. Macpherson, H. Hengartner, 2002, Nature Immunology.

Allogeneic H-2d leads to H-2b irradiation bone marrow chimeras: a) failure to transfer chimerism adoptively and b) immune reactivity of immunocompetent lymphocytes adoptively transferred to chimeras.

R. Zinkernagel, G. Maestroni, W. Pierpaoli, 1983, Immunobiology.

Enhancement of disease by neutralizing antiviral antibodies in the absence of primed antiviral cytotoxic T cells

R. Zinkernagel, M. Battegay, H. Hengartner, 1993, European journal of immunology.

"Viral déjà vu" elicits organ-specific immune disease independent of reactivity to self.

R. Zinkernagel, W. Bruck, D. Merkler, 2006, The Journal of clinical investigation.

Impaired Generation of Anti‐Viral Cytotoxicity against Lymphocytic Choriomeningitis and Vaccinia Virus in Mice Treated with CD4‐Specific Monoclonal Antibody

R. Zinkernagel, T. Leist, M. Kohler, 1989, Scandinavian journal of immunology.

A comparison of efficacy and specificity of three NK depleting antibodies.

R. Zinkernagel, R. Nuesch, S. Ehl, 1996, Journal of immunological methods.

Cytotoxic T cell activity is strain-specific in outbred mice infected with lymphocytic choriomeningitis virus.

R. Zinkernagel, P. Doherty, M. Dunlop, 1975, Journal of immunology.

Generation of virus-specific cytolytic activity in human peripheral lymphocytes after vaccination with vaccinia virus and measles virus

R. Zinkernagel, M. Oldstone, D. Reynolds, 1978, Medical Microbiology and Immunology.

Efficient immune responses in mice lacking N‐region diversity

R. Zinkernagel, C. Benoist, D. Mathis, 1995, European journal of immunology.

The role of somatic mutation in the generation of the protective humoral immune response against vesicular stomatitis virus.

R. Zinkernagel, A. Oxenius, R. Kofler, 1996, Immunity.

Macrophage activation in mice lacking thymus-derived (T) cells

R. Zinkernagel, R. Blanden, 1975, Experientia.

Evidence for a role of IFN γ in control ofListeria monocytogenes in T cell deficient mice

R. Zinkernagel, A. Meager, T. Leist, 1991, Experientia.

Treatment with anti-tumor necrosis factor alpha does not influence the immune pathological response against lymphocytic choriomeningitis virus.

R. Zinkernagel, T. Leist, 1990, Cytokine.

Cortisone-resistant effector T cells in acute lymphocytic choriomeningitis and Listeria monocytogenes infection of mice.

R. Zinkernagel, P. Doherty, 1975, The Australian journal of experimental biology and medical science.

Induced Prion Protein Controls Immune-Activated Retroviruses in the Mouse Spleen

R. Zinkernagel, P. Schwarz, J. Böni, 2007, PloS one.

Cytotoxic T cell response to lymphocytic choriomeningitis virus. Properties of precursors of effector T cells, primary effector T cells and memory T cells in vitro and in vivo.

R. Zinkernagel, P. Doherty, R. Blanden, 1977, Immunology.

Specific cytotoxic T cells eliminate cells producing neutralizing antibodies

R. Zinkernagel, O. Planz, H. Hengartner, 1996, Nature.

Deliberate removal of T cell help improves virus-neutralizing antibody production

M. Hersberger, R. Zinkernagel, K. Fink, 2004, Nature Immunology.

Recombination of Retrotransposon and Exogenous RNA Virus Results in Nonretroviral cDNA Integration

Hans Hengartner, Jacqueline Weber, Thierry Heidmann, 2009, Science.

A non-retroviral RNA virus persists in DNA form

P. Klenerman, R. Zinkernagel, H. Hengartner, 1997, Nature.

Correlation of T Cell Independence of Antibody Responses with Antigen Dose Reaching Secondary Lymphoid Organs: Implications for Splenectomized Patients and Vaccine Design1

R. Zinkernagel, H. Hengartner, B. Odermatt, 2000, The Journal of Immunology.

Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections

Hans Hengartner, Mike Recher, V. Nizet, 2009, Proceedings of the National Academy of Sciences.

Early high-affinity neutralizing anti-viral IgG responses without further overall improvements of affinity.

R M Zinkernagel, H Hengartner, V. Pliska, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Immunity to infection

R. Zinkernagel, B. Bloom, 1991, Current Opinion in Immunology.

Enhanced virus replication and inhibition of lymphocytic choriomeningitis virus disease in anti-gamma interferon-treated mice

R. Zinkernagel, T. Leist, M. Eppler, 1989, Journal of virology.

Immunity to infection

R. Zinkernagel, B. Bloom, 1991, Current Opinion in Immunology.

An easy and rapid method to screen large numbers of antibodies against internal cellular determinants.

R. Zinkernagel, L. Stitz, H. Hengartner, 1988, Journal of immunological methods.

The Nobel Lectures in Immunology The Nobel Prize for Physiology or Medicine, 1996 awarded to

R. Zinkernagel, P. Doherty, 1997 .

Infections, Immunity, and Autoimmunity

R. Zinkernagel, H. Hengartner, 2006 .

How many specific B cells are needed to protect against a virus?

R M Zinkernagel, H Hengartner, R. Zinkernagel, 1994, Journal of immunology.

Mapping of the dominant neutralizing antigenic site of a virus using infected cells.

R. Zinkernagel, H. Hengartner, C. Burkhart, 1996, Journal of immunological methods.

Specificity of in vitro cytotoxic T cell clones directed against vesicular stomatitis virus.

R. Zinkernagel, K. Rosenthal, M. Oldstone, 1983, Journal of immunology.

On immunological memory.

R M Zinkernagel, H Hengartner, R. Zinkernagel, 2000, Annual review of immunology.

T cell-dependent IFN-gamma exerts an antiviral effect in the central nervous system but not in peripheral solid organs.

R. Zinkernagel, T. Kündig, H. Hengartner, 1993, Journal of immunology.

Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors

R. Zinkernagel, Dorothea Busse, Andreas Radbruch, 2008, The Journal of experimental medicine.

Viral persistence in vivo through selection of neutralizing antibody-escape variants.

P. Klenerman, R. Zinkernagel, L. Hunziker, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Inability of mice to generate cytotoxic T lymphocytes to vesicular stomatitis virus restricted to H-2Kk or H-2Dk.

R. Zinkernagel, K. Rosenthal, 1981, Journal of immunology.

On the role of antigen in maintaining cytotoxic T-cell memory.

H. Pircher, R. Zinkernagel, T. Kündig, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Identical V beta T-cell receptor genes used in alloreactive cytotoxic and antigen plus I-A specific helper T cells.

R. Zinkernagel, R. Joho, H. Hengartner, 1985, Nature.

The concept that surveillance of self is mediated via the same set of genes that determines recognition of allogenic cells.

R. Zinkernagel, P. Doherty, 1977, Cold Spring Harbor symposia on quantitative biology.

Regulation of IgG antibody titers by the amount persisting of immune‐complexed antigen

R. Zinkernagel, T. Kündig, M. Bachmann, 1994, European journal of immunology.

Graft-versus-host reactions in F1 hybrid mice: MHC-restriction-independent generalized depression of virus-specific cytotoxic T cell response.

R. Zinkernagel, B. Pestalozzi, 1984, Immunobiology.

Positive selection of CD4+ thymocytes controlled by MHC class II gene products

R. Zinkernagel, H. Macdonald, H. Hengartner, 1988, Nature.

Lysis of infected cells in vivo by antiviral cytolytic T cells demonstrated by release of cell internal viral proteins

R. Zinkernagel, M. Battegay, D. Speiser, 1993, European journal of immunology.

Enhanced immunological surveillance in mice heterozygous at the H-2 gene complex

R. Zinkernagel, P. Doherty, ROLF M. ZINKERNAGEL, 1975, Nature.

Genes required for cytotoxicity against virus-infected target cells in K and D regions of H-2 complex

R. Zinkernagel, P. Doherty, C. David, 1975, Nature.

Peripheral clonal deletion of antiviral memory CD8+ T cells

R. Zinkernagel, D. Moskophidis, E. Laine, 1993, European journal of immunology.

Delayed type hypersensitivity (DTH) in anti-IgM-treated B cell-depleted mice: analysis of induction and effector phase.

R. Zinkernagel, H. Bazin, M. Schreier, 1988, Immunobiology.

Immunological memory ≠ protective immunity

R. Zinkernagel, 2012, Cellular and Molecular Life Sciences.

Host-determined T cell fine specificity for self-H-2 in radiation bone-marrow chimeras of standard C57BL/6 (H-2b) mutantHz1 (H-2ba), and F1 mice

R. Zinkernagel, J. Klein, P. Klein, 1978, Immunogenetics.

Cell-mediated immune response to lymphocytic choriomeningitis and vaccinia virus in rats.

R. Zinkernagel, F. Jensen, A. Althage, 1977, Journal of immunology.

Enhanced Virus Clearance by Early Inducible Lymphocytic Choriomeningitis Virus-Neutralizing Antibodies in Immunoglobulin-Transgenic Mice

R. Zinkernagel, T. Rülicke, H. Hengartner, 1998, Journal of Virology.

Nonneutralizing antibodies binding to the surface glycoprotein of lymphocytic choriomeningitis virus reduce early virus spread

J. Weber, R. Zinkernagel, K. McCoy, 2006, The Journal of experimental medicine.

Primary antibody responses to a well-defined and unique hapten are not enhanced by preimmunization with carrier: analysis in a viral model.

R M Zinkernagel, H Hengartner, R. Zinkernagel, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Deletion of self-reactive T cells before entry into the thymus medulla

R. Zinkernagel, H. Macdonald, H. Hengartner, 1988, Nature.

Combinatorial immunoglobulin light chain variability creates sufficient B cell diversity to mount protective antibody responses against pathogen infections

R. Zinkernagel, H. Hengartner, A. Isibasi, 2003, European journal of immunology.

An acquired immune suppression in mice caused by infection with lymphocytic choriomeningitis virus

R. Zinkernagel, H. Hengartner, R. Gobet, 1988, European journal of immunology.

What if protective immunity is antigen—driven and not due to so‐called “memory” B and T cells?

R. Zinkernagel, 2018, Immunological reviews.

What can we learn about human immunodeficiency virus infection from a study of lymphocytic choriomeningitis virus?

P. Klenerman, R. Zinkernagel, Rolf M. Zinkernagel, 1997, Immunological reviews.

T-cell immunoincompetence in allogeneic chimerism.

R. Zinkernagel, D. Speiser, M. Jeannet, 1992, The New England journal of medicine.

Biological role of major transplantation antigens in T cell self-recognition

R. Zinkernagel, 1986, Experientia.

Biological Role of Major Transplantation Antigens in T Cell Self-recognition: Possible Consequences in Clinical Medicine

R. Zinkernagel, 1986 .

Immunity 2000.

R. Zinkernagel, 2000, Immunology today.

Response : Vaccination, Immunopathology, and Immunity

R. Zinkernagel, H. Hengartner, S. Oehen, 1991, Science.

“Negative Vaccination” by Specific CD4+ T Cell Tolerisation Enhances Virus-Specific Protective Antibody Responses

R. Zinkernagel, M. Löhning, A. Hegazy, 2007, PloS one.

Phenotypic analysis of TNFR1-deficient mice and characterization of TNFR1-deficient fibroblasts in vitro.

R. Zinkernagel, W. Lesslauer, F. Mackay, 1994, Circulatory shock.

Assessing the mechanisms that give rise to autoimmunity.

R. Zinkernagel, 2000, Science.

Variable immune response against a developmentally regulated self-antigen.

R. Zinkernagel, T. Rülicke, A. Clark, 1999, Journal of Autoimmunity.

Comparison of the sensitivity of in vivo and in vitro assays for detection of antiviral cytotoxic T cell activity.

R. Zinkernagel, T. Kündig, M. Bachmann, 1993, Cellular immunology.

Response from Zinkernagel et al

R. Zinkernagel, T. Kündig, M. Bachmann, 1997 .

Formalin Inactivation ofVesicular Stomatitis VirusImpairs T-Cell- butNotT-Help-Independent

R. Zinkernagel, T. Kündig, H. Hengartner, 1993 .

Extrathymic positive selection of alpha beta T-cell precursors in nude mice.

R. Zinkernagel, D. Speiser, U. Stübi, 1992, Nature.

Parameters governing exhaustion of rare T cell‐independent neutralizing IgM‐producing B cells after LCMV infection

J. Weber, R. Zinkernagel, L. Hangartner, 2006, European journal of immunology.

Correlation of tolerogenicity of a viral antigen with its immunogenicity.

R. Zinkernagel, T. Fehr, M. Bachmann, 1997, Journal of immunology.

Targeting the mouse genome: a compendium of knockouts

R. Zinkernagel, L. Reis, U. Steinhoff, 1995 .

Virus‐specific major MHC class II‐restricted TCR‐transgenic mice: effects on humoral and cellular immune responses after viral infection

R. Zinkernagel, A. Oxenius, M. Bachmann, 1998, European journal of immunology.

Cell-mediated immune response to Salmonella typhimurium infection in mice: development of nonspecific bactericidal activity against Listeria monocytogenes

R. Zinkernagel, 1976, Infection and immunity.

Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice

R. Zinkernagel, T. Mak, M. Battegay, 1994, Journal of virology.

Specificity of Virus‐Immune Effector T Cells for H‐2K or H‐2D Compatible Interactions: Implications for H‐Antigen Diversity

R. Zinkernagel, P. Doherty, R. Blanden, 1976, Transplantation reviews.

Histological analysis of CD11c‐DTR/GFP mice after in vivo depletion of dendritic cells

R. Zinkernagel, R. Schwendener, B. Odermatt, 2005, Clinical and experimental immunology.

Immune response against lymphocytic choriomeningitis virus infection in mice without CD8 expression

R. Zinkernagel, T. Mak, W. Fung-Leung, 1991, The Journal of experimental medicine.

Virus-triggered AIDS: a T-cell-mediated immunopathology?

R. Zinkernagel, 1988, Immunology today.

Virus-induced acquired immune suppression by cytotoxic T cell-mediated immunopathology.

R. Zinkernagel, 1992, Veterinary microbiology.

Severe immunodeficiency associated with a human immunodeficiency virus 1 NEF/3'-long terminal repeat transgene

R. Zinkernagel, D. Lindemann, J. Mous, 1994, The Journal of experimental medicine.

Some general aspects of immunity to viruses.

R. Zinkernagel, 1994, Vaccine.

Lymphocytic choriomeningitis virus and immunology.

R. Zinkernagel, R. Zinkernagel, 2002, Current topics in microbiology and immunology.

R. Zinkernagel, D. Speiser, H. Macdonald, 1990, The Journal of experimental medicine.

Immunobiology of cytotoxic T-cell escape mutants of lymphocytic choriomeningitis virus

R. Zinkernagel, D. Moskophidis, R. Zinkernagel, 1995, Journal of virology.

T cell tolerance to Mlsa encoded antigens in T cell receptor V beta 8.1 chain transgenic mice.

H. Pircher, R. Zinkernagel, T. Mak, 1989, The EMBO journal.

Immunodominant T Cell Epitope from Signal Sequence

R. Zinkernagel, M. Buchmeier, 1992, Science.

Capacity of sensitized thymus-derived lymphocytes to induce fatal lymphocytic choriomeningitis is restricted by the H-2 gene complex.

R. Zinkernagel, P. Doherty, R. M. Zinernagel, 1975, Journal of immunology.

BriefDefinitive Report TUMOR NECROSIS FACTOR a IN CEREBROSPINAL FLUID DURING BACTERIAL, BUT NOT VIRAL, MENINGITIS Evaluation in Murine Model Infections and in Patients

R. Zinkernagel, A. Fontana, S. Kam‐Hansen, 2003 .

Persistence of lymphocytic choriomeningitis virus at very low levels in immune mice.

P. Klenerman, R. Zinkernagel, L. Hunziker, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Dendritic Cells Induce Autoimmune Diabetes and Maintain Disease via De Novo Formation of Local Lymphoid Tissue

R. Zinkernagel, B. Ludewig, H. Hengartner, 1998, The Journal of experimental medicine.

Virus-induced Transient Bone Marrow Aplasia: Major Role of Interferon- (cid:97) / (cid:98) during Acute Infection with the Noncytopathic Lymphocytic Choriomeningitis Virus

R. Zinkernagel, Daniel Binder, H. Hengartner, 1997 .

Rejection of allogeneic tumor cells growing in mouse cerebrospinal fluid Functional analysis of the inflammatory process

C. K. Grant, R. Zinkernagel, P. Doherty, 1981, Journal of Neuroimmunology.

Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors

R. Zinkernagel, Dorothea Busse, Andreas Radbruch, 2008, The Journal of experimental medicine.

Induction of optimal anti‐viral neutralizing B cell responses by dendritic cells requires transport and release of virus particles in secondary lymphoid organs

R. Zinkernagel, B. Ludewig, H. Hengartner, 2000, European journal of immunology.

Assessment of some genetic non-MHC differences with GVHR-induced anti-listeria activity of macrophages

R. Zinkernagel, A. Althage, 2004, Immunogenetics.

Protective T Cell–Independent Antiviral Antibody Responses Are Dependent on Complement

R. Zinkernagel, H. Hengartner, B. Odermatt, 1999, The Journal of experimental medicine.

Brief Definitive Report H-2 COMPATIBILITY REQUIREMENT FOR VIRUS-SPECIFIC T-CELL-MEDIATED CYTOLYSIS The H-2 K Struc ture Involved is Coded by a Single Cistron Defined by H-2 K b Mutan t Mice

R. Zinkernagel, 2003 .

Cd40-cd40 Ligand Interactions Are Critical in T-b Cooperation but Not for Other Anti-viral Cd4 § T Cell Functions

R. Zinkernagel, H. Hengartner, C. R. Maliszewski, 1996 .

Neutralizing antiviral antibodies reduce hematogenic viral spread but not antiviral cytotoxic T cell induction and subsequent immunopathology.

R. Zinkernagel, M. Battegay, L. Hunziker, 2001, The Journal of infectious diseases.

Role of the H-2 gene complex in cell-mediated immunity to infectious disease.

R. Zinkernagel, 1977, Transplantation proceedings.

Role of TCR‐restricting MHC density and thymic environment on selection and survival of cells expressing low‐affinity T cell receptors

R. Zinkernagel, B. Rocha, H. Hengartner, 2004, European journal of immunology.

Promethean viruses?

R. Zinkernagel, P. Allen, 1994, Nature.

Effect of Cell Dose and Dose of Infectious Agent on Expression of Protection Against Listeria monocytogenes and Ectromelia Virus in Cell Transfer Models

R. Zinkernagel, R. Blanden, T. Pang, 1975, Infection and immunity.

Studies on immunity to lymphocytic choriomeningitis virus

R. Zinkernagel, L. Stitz, H. Hengartner, 2005, Medical Microbiology and Immunology.

Transplantationsantigene

R. Zinkernagel, 1982, Naturwissenschaften.

How Strict Is the MHC Restriction of T Cells

R. Zinkernagel, 1981 .

Cell-mediated immunity to viruses in hamsters.

R. Zinkernagel, W. Duncan, F. Jensen, 1978, Federation proceedings.

WHAT ABOUT MHC RESTRICTED T CELLS

R. Zinkernagel, 1980 .