D. Srivastava

发表

Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis

Yong Zhao, Eva Samal, D. Srivastava, 2005, Nature.

MicroRNA regulation of cell lineages in mouse and human embryonic stem cells.

R. Yeh, B. Conklin, D. Srivastava, 2008, Cell stem cell.

Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands

Yufeng Shen, Alessandro Giardini, Hongyu Zhao, 2017, Nature Genetics.

GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5

Jonathan C. Cohen, D. Srivastava, R. Matsuoka, 2003, Nature.

Mutations in NOTCH1 cause aortic valve disease

D. Srivastava, Alecia N. Muth, V. Garg, 2005, Nature.

Making or Breaking the Heart: From Lineage Determination to Morphogenesis

D. Srivastava, 2006, Cell.

Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors

V. Vedantham, B. Bruneau, D. Srivastava, 2010, Cell.

Dysregulation of Cardiogenesis, Cardiac Conduction, and Cell Cycle in Mice Lacking miRNA-1-2

Michael T. McManus, V. Vedantham, Yong Zhao, 2007, Cell.

Single-cell analysis of cardiogenesis reveals basis for organ level developmental defects

A. del Sol, D. Srivastava, Sanjeev S. Ranade, 2019, Nature.

A role for RNA post-transcriptional regulation in satellite cell activation

D. Srivastava, B. Olwin, D. Cornelison, 2012, Skeletal Muscle.

A developmental view of microRNA function.

Yong Zhao, D. Srivastava, 2007, Trends in biochemical sciences.

Dynamic and Coordinated Epigenetic Regulation of Developmental Transitions in the Cardiac Lineage

Alexander R. Pico, Genevieve D. Erwin, K. Pollard, 2012, Cell.

Genetics of Human Cardiovascular Disease

D. Srivastava, S. Kathiresan, 2012, Cell.

Notch1 represses osteogenic pathways in aortic valve cells.

D. Srivastava, Vishal Nigam, 2009, Journal of molecular and cellular cardiology.

Hand2 function in second heart field progenitors is essential for cardiogenesis.

D. Srivastava, Kathryn N. Ivey, B. Black, 2011, Developmental biology.

Miniaturized iPS-Cell-Derived Cardiac Muscles for Physiologically Relevant Drug Response Analyses

Kevin E. Healy, Tejal A. Desai, Bruce R. Conklin, 2016, Scientific Reports.

Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors.

Masaki Ieda, Deepak Srivastava, Yohei Hayashi, 2010, Cell.

MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling.

Zhe Han, Deepak Srivastava, Chulan Kwon, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Stem cell therapy for cardiac disease

Deepak Srivastava, Harold S. Bernstein, D. Srivastava, 2012, Pediatric Research.

A unified test of linkage analysis and rare-variant association for analysis of pedigree sequence data

Gustavo Glusman, Paul Scheet, Mark Yandell, 2014, Nature Biotechnology.

A genetic blueprint for cardiac development

Deepak Srivastava, D. Srivastava, E. Olson, 2000, Nature.

Genetic regulation of cardiogenesis and congenital heart disease.

Deepak Srivastava, D. Srivastava, 2006, Annual review of pathology.

Heart disease: An ongoing genetic battle?

D. Srivastava, 2004, Nature.

Apoptosis During Cardiovascular Development

D. Srivastava, B. L. Langille, S. Fisher, 2000, Circulation research.

Apoptosis and Heart Failure: A Critical Review of the Literature Vascular Cell Apoptosis in Remodeling, Restenosis, and Plaque Rupture Endothelial Cell Apoptosis in Angiogenesis and Vessel Regression Apoptosis During Cardiovascular Development Myocyte Apoptosis in Ischemic Heart Disease

D. Srivastava, B. L. Langille, S. Fisher, 2000 .

Reprogramming of mouse fibroblasts into cardiomyocyte-like cells in vitro

D. Srivastava, M. Ieda, Ji-Dong Fu, 2013, Nature Protocols.

Chemical Enhancement of In Vitro and In Vivo Direct Cardiac Reprogramming

D. Srivastava, Yen-Sin Ang, Kathryn N. Ivey, 2017, Circulation.

Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function

D. Srivastava, E. Olson, E. van Rooij, 2007, Proceedings of the National Academy of Sciences.

Modeling Human Protein Aggregation Cardiomyopathy Using Murine Induced Pluripotent Stem Cells

D. Srivastava, Kathryn N. Ivey, I. Benjamin, 2013, Stem cells translational medicine.

Gαq and Gα11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme

D. Srivastava, Kathryn N. Ivey, E. Olson, 2003 .

Integration of Protein Interactome Networks with Congenital Heart Disease Variants Reveals Candidate Disease Genes

K. Pollard, N. Krogan, B. Bruneau, 2021, bioRxiv.

Cardiac reprogramming: from mouse toward man.

D. Srivastava, E. Berry, 2013, Current opinion in genetics & development.

EM-mosaic detects mosaic point mutations that contribute to congenital heart disease

K. B. Manheimer, W. Chung, J. Seidman, 2020, Genome Medicine.

Practical Integration‐Free Episomal Methods for Generating Human Induced Pluripotent Stem Cells

D. Srivastava, Kathryn N. Ivey, S. Yamanaka, 2015, Current protocols in human genetics.

Wnt/β-Catenin signaling acts at multiple developmental stages to promote mammalian cardiogenesis

Chulan Kwon, D. Srivastava, Kimberly R. Cordes, 2008, Cell cycle.

Fibronectin mediates mesendodermal cell fate decisions

Chulan Kwon, D. Srivastava, B. Kaynak, 2013, Development.

The basic helix-loop-helix transcription factor, dHAND, is required for vascular development.

D. Srivastava, E. Olson, H. Yamagishi, 2000, The Journal of clinical investigation.

Expandable Cardiovascular Progenitor Cells Reprogrammed from Fibroblasts.

C. I. Spencer, B. Bruneau, D. Srivastava, 2016, Cell stem cell.

Monkeying around with cardiac progenitors: hope for the future.

D. Srivastava, L. Qian, Li Qian, 2010, The Journal of clinical investigation.

Comparative analysis of diverse cell states establishes an epigenetic basis for inferring regulatory genes governing cell identity

Woo Jun Shim, M. Bodén, D. Srivastava, 2019 .

Small molecules enable cardiac reprogramming of mouse fibroblasts with a single factor, Oct4.

C. I. Spencer, D. Srivastava, Yu Zhang, 2014, Cell reports.

Context-Specific Transcription Factor Functions Regulate Epigenomic and Transcriptional Dynamics during Cardiac Reprogramming.

K. Pollard, D. Srivastava, Kathryn N. Ivey, 2019, Cell stem cell.

Unique Transcription Factor Functions Regulate Epigenetic and Transcriptional Dynamics During Cardiac Reprogramming

K. Pollard, D. Srivastava, Kathryn N. Ivey, 2019, bioRxiv.

The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling

D. Srivastava, T. Behrens, Sangho Yu, 2011, Developmental dynamics : an official publication of the American Association of Anatomists.

Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors

D. Srivastava, J. McAnally, J. Maeda, 2004, Development.

Early post-zygotic mutations contribute to congenital heart disease

K. B. Manheimer, W. Chung, J. Seidman, 2019, bioRxiv.

The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling

D. Srivastava, E. Hsiao, S. A. Wong, 2016, Stem Cell Research & Therapy.

Heart malformation: what are the chances it could happen again?

D. Srivastava, J. Shieh, Joseph T C Shieh, 2009, Circulation.

The paradoxical patent ductus arteriosus.

D. Srivastava, Kathryn N. Ivey, 2006, The Journal of clinical investigation.

Chemical-induced, nonlethal, developmental model of dissecting aortic aneurysm.

D. Srivastava, P. Boor, M. B. Trent, 2006, Birth defects research. Part A, Clinical and molecular teratology.

Stromal Cell–Derived Factor-1α Is Cardioprotective After Myocardial Infarction

James W. Smyth, D. Srivastava, J. Fish, 2008, Circulation.

MicroRNAs in Cardiac Development

D. Srivastava, Kathryn N. Ivey, Kimberly R. Cordes, 2010, Pediatric Cardiology.

Integration of Protein Interactome Networks with Congenital Heart Disease Variants Reveals Candidate Disease Genes

K. Pollard, N. Krogan, B. Bruneau, 2020, bioRxiv.

Robust identification of deletions in exome and genome sequence data based on clustering of Mendelian errors

K. B. Manheimer, W. Chung, J. Seidman, 2017, bioRxiv.

Thymosin β4 and cardiac repair

D. Srivastava, J. DiMaio, E. Olson, 2010, Annals of the New York Academy of Sciences.

Thymosin beta4 mediated PKC activation is essential to initiate the embryonic coronary developmental program and epicardial progenitor cell activation in adult mice in vivo.

Jeffrey E. Thatcher, D. Srivastava, J. DiMaio, 2009, Journal of molecular and cellular cardiology.

Congenital Heart Disease–Causing Gata4 Mutation Displays Functional Deficits In Vivo

D. Srivastava, W. Pu, N. Sachan, 2012, PLoS genetics.

' s personal copy Hand 2 function in second heart fi eld progenitors is essential for cardiogenesis

D. Srivastava, Kathryn N. Ivey, B. Black, 2011 .

Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development.

D. Srivastava, J. Richardson, C. Lo, 2009, Developmental biology.

Transcriptional Regulation During Development of the Ductus Arteriosus

D. Srivastava, Kathryn N. Ivey, Joseph A Garcia, 2008, Circulation research.

Thymosin β4 Is Cardioprotective after Myocardial Infarction

D. Srivastava, A. Saxena, J. Michael DiMaio, 2007 .

CHAMP, a novel cardiac-specific helicase regulated by MEF2C.

R. Passier, D. Srivastava, E. Olson, 2001, Developmental biology.

Human eHAND, but not dHAND, is down-regulated in cardiomyopathies.

D. Srivastava, R. Roberts, D. Li, 2001, Journal of molecular and cellular cardiology.

Specification of the mouse cardiac conduction system in the absence of Endothelin signaling.

V. Vedantham, D. Srivastava, B. Black, 2014, Developmental biology.

pumpto meet needs: integrin-linked kinase and the cardiac

D. Srivastava, Sangho Yu, 2009 .

Stretching to meet needs: integrin-linked kinase and the cardiac pump.

D. Srivastava, Sangho Yu, 2006, Genes & development.

Neurotrophin–3 knocks heart off Trk

D. Srivastava, E. Olson, 1996, Nature Medicine.

A Transcriptional Switch Governing Fibroblast Plasticity Underlies Reversibility of Chronic Heart Disease

Saptarsi M. Haldar, Pawel F. Przytycki, K. Pollard, 2020, bioRxiv.

BRD4 Interacts with GATA4 to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes

Saptarsi M. Haldar, D. Srivastava, A. Padmanabhan, 2020, bioRxiv.

D. Srivastava, E. Olson, I. S. Kathiriya, 2004, Journal of Biological Chemistry.

A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress.

Robyn M. Kaake, N. Krogan, B. Conklin, 2017, JCI insight.

Single Cell Epigenetics Reveal Cell-Cell Communication Networks in Normal and Abnormal Cardiac Morphogenesis

Pawel F. Przytycki, K. Pollard, D. Srivastava, 2022, bioRxiv.

Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation.

Saptarsi M. Haldar, Charles Y. Lin, D. Srivastava, 2019, Circulation research.

Cold shock domain–containing protein E1 is a posttranscriptional regulator of the LDL receptor

K. Shokat, D. Srivastava, P. Natarajan, 2022, Science Translational Medicine.

Transcription Factor GATA4 Regulates Cell Type–Specific Splicing Through Direct Interaction With RNA in Human Induced Pluripotent Stem Cell–Derived Cardiac Progenitors

L. Steinmetz, K. Pollard, V. Vedantham, 2022, Circulation.

Tbx1 regulates oral epithelial adhesion and palatal development.

D. Srivastava, J. Richardson, Masataka Nakamura, 2012, Human molecular genetics.

Single Cell Multimodal Analyses Reveal Epigenomic and Transcriptomic Basis for Birth Defects in Maternal Diabetes

D. Srivastava, Sanjeev S. Ranade, Reuben Thomas, 2022, bioRxiv.

Galphaq and Galpha11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme.

D. Srivastava, Kathryn N. Ivey, E. Olson, 2003, Developmental biology.

BBRC Hrt and Hes negatively regulate Notch signaling through interactions with RBP-J j

D. Srivastava, I. S. Kathiriya, M. Murakami, 2006 .

Factors for Cardiac Reprogramming

D. Srivastava, M. Ieda, 2012 .

Deepak Srivastava and Masaki Ieda Critical Factors for Cardiac Reprogramming

D. Srivastava, M. Ieda, 2012 .

Vertebrate heart growth is regulated by functional antagonism between Gridlock and Gata5

Terri T. Ni, D. Srivastava, H. Wan, 2007, Proceedings of the National Academy of Sciences.

Stromal Cell–Derived Factor-1 (cid:1) Is Cardioprotective After Myocardial Infarction Molecular Cardiology

James W. Smyth, D. Srivastava, J. Fish, 2008 .

Loss of Tbx1 induces bone phenotypes similar to cleidocranial dysplasia.

D. Srivastava, J. Richardson, Masataka Nakamura, 2015, Human molecular genetics.

Direct cardiac reprogramming: from developmental biology to cardiac regeneration.

D. Srivastava, L. Qian, Li Qian, 2013, Circulation research.

MicroRNA regulation of cardiovascular development.

D. Srivastava, Kimberly R. Cordes, 2009, Circulation research.

Heart disease modelling adds a Notch to its belt

D. Srivastava, Casey A. Gifford, 2015, Nature Cell Biology.

Oxygen: double-edged sword in cardiac function and repair.

D. Srivastava, Yen-Sin Ang, 2014, Circulation research.

Left, right… which way to turn?

D. Srivastava, 1997, Nature Genetics.

A Mesp1-dependent developmental breakpoint in transcriptional and epigenomic specification of early cardiac precursors

B. Bruneau, D. Srivastava, Sanjeev S. Ranade, 2022, bioRxiv.

Tooth-type specific expression of dHAND/Hand2: possible involvement in murine lower incisor morphogenesis

D. Srivastava, H. Yamagishi, S. Wakisaka, 2002, Cell and Tissue Research.

Genetic basis for congenital heart defects: current knowledge: a scientific statement from the American Heart Association Congenital Cardiac Defects Committee, Council on Cardiovascular Disease in the Young: endorsed by the American Academy of Pediatrics.

D. Srivastava, B. Gelb, C. Basson, 2007, Circulation.

Molecular mechanisms of ventricular hypoplasia.

D. Srivastava, P. Gottlieb, E. Olson, 2002, Cold Spring Harbor symposia on quantitative biology.

Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling.

D. Srivastava, Kathryn N. Ivey, R. Ross, 2009, Developmental cell.

Functional Attenuation of Ufd1l, a 22q11.2 Deletion Syndrome Candidate Gene, Leads to Cardiac Outflow Septation Defects in Chicken Embryos

D. Srivastava, B. Hierck, H. Yamagishi, 2003, Pediatric Research.

Molecular Pathways Controlling Heart Development

D. Srivastava, E. Olson, 1996, Science.

Endotoxin-Induced Cardiomyopathy and Systemic Inflammation in Mice Is Prevented by Aldose Reductase Inhibition

D. Srivastava, J. DiMaio, K. Ramana, 2006, Circulation.

Multi-Imaging Method to Assay the Contractile Mechanical Output of Micropatterned Human iPSC-Derived Cardiac Myocytes

Deepak Srivastava, Beth L Pruitt, Bruce R Conklin, 2017, Circulation research.

Regulation of Cell Cycle to Stimulate Adult Cardiomyocyte Proliferation and Cardiac Regeneration

D. Srivastava, Yen-Sin Ang, P. Zhou, 2017, Cell.

Oligogenic inheritance of a human heart disease involving a genetic modifier

D. Srivastava, S. Wyman, Kathryn N. Ivey, 2019, Science.

Thymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair

D. Srivastava, J. DiMaio, A. Saxena, 2004, Nature.

Elevated miR-499 Levels Blunt the Cardiac Stress Response

D. Srivastava, Yu Huang, J. Gilmore, 2011, PloS one.

microRNA-138 modulates cardiac patterning during embryonic development

D. Srivastava, Kathryn N. Ivey, D. Stainier, 2008, Proceedings of the National Academy of Sciences.

Transient Cell Cycle Induction in Cardiomyocytes to Treat Subacute Ischemic Heart Failure

D. Srivastava, Kathryn N. Ivey, P. Lorkiewicz, 2022, Circulation.

Transient Cell Cycle Induction in Cardiomyocytes to Treat Ischemic Heart Failure

D. Srivastava, Kathryn N. Ivey, P. Lorkiewicz, 2020 .

A Long Non-Coding RNA Defines an Epigenetic Checkpoint in Cardiac Hypertrophy

P. Zhang, D. Srivastava, Yen-Sin Ang, 2016 .

HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments.

D. Srivastava, E. Olson, J. Richardson, 1999, Developmental biology.

Signaling Pathways Involved in Cardiogenesis

Chulan Kwon, D. Srivastava, 2010 .

Genetic Basis for Congenital Heart Defects: Current Knowledge

D. Srivastava, B. Gelb, C. Basson, 2007, Pediatrics.

The genetics of cardiac birth defects.

D. Srivastava, J. Ransom, 2007, Seminars in cell & developmental biology.

Cardiovascular Disease in the Young : Statement From the American Heart Association Congenital Cardiac Defects Genetic Basis for Congenital Heart Defects : Current Knowledge : A Scientific

D. Srivastava, B. Gelb, C. Basson, 2007 .

Hrt and Hes negatively regulate Notch signaling through interactions with RBP-Jkappa.

D. Srivastava, I. S. Kathiriya, M. Murakami, 2006, Biochemical and biophysical research communications.

Genetic Underpinnings of Cardiogenesis and Congenital Heart Disease

D. Srivastava, V. Garg, 2005 .

CHAPTER 335 – Signaling Pathways Involved in Cardiogenesis

D. Srivastava, 2003 .

Building a heart: Implications for congenital heart disease

D. Srivastava, 2003, Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology.

Genetic assembly of the heart: implications for congenital heart disease.

D. Srivastava, 2001, Annual review of physiology.

Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling.

D. Srivastava, E. Olson, O. Nakagawa, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Genomic analyses implicate noncoding de novo variants in congenital heart disease

Kathleen M. Chen, K. B. Manheimer, G. Marth, 2020, Nature Genetics.

CHAPTER 9 – Aetiology of Congenital Cardiac Disease

B. Bruneau, D. Srivastava, J. Burn, 2010 .

miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes

L. V. Van Laake, D. Srivastava, M. Wendland, 2011, The Journal of experimental medicine.

microRNAs as Developmental Regulators.

D. Srivastava, Kathryn N. Ivey, Kathryn N Ivey, 2015, Cold Spring Harbor perspectives in biology.

Role of microRNAs in Cardiovascular Biology

Eva Samal, D. Srivastava, 2007 .

A molecular pathway revealing a genetic basis for human cardiac and craniofacial defects.

D. Srivastava, R. Matsuoka, V. Garg, 1999, Science.

A History and Interaction of Outflow Progenitor Cells Implicated in “Takao Syndrome”

D. Srivastava, K. Uchida, T. Tsuchihashi, 2016 .

Unraveling the genetic and developmental mysteries of 22q11 deletion syndrome.

D. Srivastava, H. Yamagishi, 2003, Trends in molecular medicine.

Tbx1, a DiGeorge syndrome candidate gene, is regulated by sonic hedgehog during pharyngeal arch development.

D. Srivastava, I. S. Kathiriya, V. Garg, 2001, Developmental biology.

NOTCH1 regulates matrix gla protein and calcification gene networks in human valve endothelium.

D. Srivastava, Kathryn N. Ivey, Xianzhong Meng, 2015, Journal of molecular and cellular cardiology.

Human Disease Modeling Reveals Integrated Transcriptional and Epigenetic Mechanisms of NOTCH1 Haploinsufficiency

K. Pollard, B. Bruneau, D. Srivastava, 2015, Cell.

Congenital heart disease: entering a new era of human genetics.

Deepak Srivastava, B. Bruneau, D. Srivastava, 2014, Circulation research.

Commentaries on Cutting Edge Science

Deepak Srivastava, Benoit G. Bruneau, B. Bruneau, 2014 .

Fending for a Braveheart

D. Srivastava, Kimberly R. Cordes Metzler, 2013, The EMBO journal.

Use of iPSCs to Generate Cardiac Myocytes and Repair Infarcted Myocardium Genomic Stability Issues Associated With the Reprogramming Process Differentiation of iPSCs Into Mature Myocytes

D. Srivastava, L. Qian, Li Qian, 2013 .

In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes

Li Qian, Deepak Srivastava, Lei Liu, 2011, Nature.

De Novo Damaging Variants, Clinical Phenotypes, and Post-Operative Outcomes in Congenital Heart Disease

Michael F Swartz, K. B. Manheimer, W. Chung, 2020, Circulation. Genomic and precision medicine.

Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer.

D. Srivastava, J. McAnally, T. Kume, 2003, Genes & development.

A transcriptional switch governs fibroblast activation in heart disease

Saptarsi M. Haldar, Pawel F. Przytycki, K. Pollard, 2021, Nature.

Direct Reprogramming of Human Fibroblasts toward a Cardiomyocyte-like State

Li Qian, Deepak Srivastava, Yohei Hayashi, 2013, Stem cell reports.

The neural crest-enriched microRNA miR-452 regulates epithelial-mesenchymal signaling in the first pharyngeal arch

D. Srivastava, Kathryn N. Ivey, Kimberly R. Cordes, 2010, Development.

Derivation conditions impact X-inactivation status in female human induced pluripotent stem cells.

N. Yamada, P. Tsang, B. Conklin, 2012, Cell stem cell.

Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis

D. Srivastava, P. Gottlieb, E. Olson, 2002, Nature Genetics.

A Subclass of bHLH Proteins Required for Cardiac Morphogenesis

D. Srivastava, E. Olson, P. Cserjesi, 1995, Science.

miR-126 regulates angiogenic signaling and vascular integrity.

Ru-Fang Yeh, Deepak Srivastava, Joshua D. Wythe, 2008, Developmental cell.

The let-7/LIN-41 pathway regulates reprogramming to human induced pluripotent stem cells by controlling expression of prodifferentiation genes.

D. Srivastava, S. Yamanaka, Kazutoshi Takahashi, 2014, Cell stem cell.

A resource for the conditional ablation of microRNAs in the mouse.

Michael T. McManus, P. D. de Jong, Y. Yoshinaga, 2012, Cell reports.

miR-145 and miR-143 Regulate Smooth Muscle Cell Fate Decisions

Deepak Srivastava, Sarah U. Morton, Joseph M. Miano, 2009, Nature.

Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND

D. Srivastava, M. Kirby, E. Olson, 1997, Nature Genetics.

Recent advances in direct cardiac reprogramming.

D. Srivastava, Penghzi Yu, 2015, Current opinion in genetics & development.

Critical factors for cardiac reprogramming.

D. Srivastava, M. Ieda, 2012, Circulation research.

Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart

Deepak Srivastava, Kazuko Koshiba-Takeuchi, B. Bruneau, 2006, Nature Genetics.

The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner

D. Srivastava, E. Olson, J. Richardson, 2004, Development.

MicroRNAs as regulators of differentiation and cell fate decisions.

Deepak Srivastava, D. Srivastava, Kathryn N. Ivey, 2010, Cell stem cell.

Loss of Apaf-1 leads to partial rescue of the HAND2-null phenotype.

D. Srivastava, J. Herz, N. Honarpour, 2005, Developmental biology.

Efficient CRISPR/Cas9‐Based Genome Engineering in Human Pluripotent Stem Cells

B. Conklin, D. Srivastava, S. Yamanaka, 2016, Current protocols in human genetics.

Reporter-Based Isolation of Induced Pluripotent Stem Cell– and Embryonic Stem Cell–Derived Cardiac Progenitors Reveals Limited Gene Expression Variance

L. V. Van Laake, B. Conklin, D. Srivastava, 2010, Circulation research.

Derived Cardiac Progenitors Reveals Limited Gene Expression Variance Reporter-Based Isolation of Induced Pluripotent Stem Cell and Embryonic Stem

D. Srivastava, E. Hsiao, Yu Huang, 2010 .

Limited Gene Expression Variation in Human Embryonic Stem Cell and Induced Pluripotent Stem Cell‐Derived Endothelial Cells

D. Srivastava, Kathryn N. Ivey, J. Cooke, 2013, Stem cells.

The Antiproliferative Action of Progesterone in Uterine Epithelium Is Mediated by Hand2

D. Srivastava, P. Cooke, F. DeMayo, 2011, Science.

GATA6 mutations in hiPSCs inform mechanisms for maldevelopment of the heart, pancreas, and diaphragm

W. Chung, J. Seidman, D. Srivastava, 2020, eLife.

Single-cell analysis of cardiogenesis reveals basis for organ level developmental defects

A. del Sol, D. Srivastava, Sanjeev S. Ranade, 2019, Nature.

CSDE1 is a Post-Transcriptional Regulator of the LDL Receptor

K. Shokat, D. Srivastava, A. Padmanabhan, 2020 .

Hypoxic Repression of Endothelial Nitric-oxide Synthase Transcription Is Coupled with Eviction of Promoter Histones*♦

D. Srivastava, J. Fish, C. Matouk, 2009, The Journal of Biological Chemistry.

Ephrin-B2 reverse signaling is required for axon pathfinding and cardiac valve formation but not early vascular development.

Chad A. Cowan, D. Srivastava, C. Cowan, 2004, Developmental biology.

Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1

D. Srivastava, E. Olson, D. McFadden, 1998, Nature Genetics.

MicroRNA Regulation of Cardiac Development and Disease

D. Srivastava, Kimberly R. Cordes, 2010 .

Disease Model of GATA4 Mutation Reveals Transcription Factor Cooperativity in Human Cardiogenesis

Beth L. Pruitt, Deepak Srivastava, Haiyuan Yu, 2016, Cell.

BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure

Saptarsi M. Haldar, D. Srivastava, J. Bradner, 2017, Science Translational Medicine.

Conversion of human fibroblasts into functional cardiomyocytes by small molecules

Yu Zhang, Deepak Srivastava, Nan Cao, 2016, Science.

MicroRNAs: Opening a New Vein in Angiogenesis Research

D. Srivastava, J. Fish, Jason E. Fish, 2009, Science Signaling.

A genome-wide screen reveals a role for microRNA-1 in modulating cardiac cell polarity.

Chulan Kwon, D. Srivastava, I. N. King, 2011, Developmental cell.

MicroRNA-10 Regulates the Angiogenic Behavior of Zebrafish and Human Endothelial Cells by Promoting Vascular Endothelial Growth Factor Signaling

H. Augustin, D. Srivastava, Kathryn N. Ivey, 2012, Circulation research.

Spatiotemporal regulation of an Hcn4 enhancer defines a role for Mef2c and HDACs in cardiac electrical patterning.

V. Vedantham, D. Srivastava, Yu Huang, 2013, Developmental biology.

Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression

D. Srivastava, T. Capellini, L. Selleri, 2006, Development.

The Homeodomain Transcription Factor Irx5 Establishes the Mouse Cardiac Ventricular Repolarization Gradient

B. Bruneau, D. Srivastava, C. Antzelevitch, 2005, Cell.

In Vivo Cellular Reprogramming: The Next Generation

Deepak Srivastava, Natalie DeWitt, D. Srivastava, 2016, Cell.

Transcription factor protein interactomes reveal genetic determinants in heart disease

Mauro W. Costa, K. Pollard, N. Krogan, 2022, Cell.

Chromosomal haplotypes by genetic phasing of human families.

Jared C. Roach, Gustavo Glusman, David J. Galas, 2011, American journal of human genetics.

Developmental and genetic aspects of congenital heart disease.

D. Srivastava, 1999, Current opinion in cardiology.

Contractility of single cardiomyocytes differentiated from pluripotent stem cells depends on physiological shape and substrate stiffness

Deepak Srivastava, Beth L Pruitt, Yen-Sin Ang, 2015, Proceedings of the National Academy of Sciences.

Genetic and comparative mapping of genes dysregulated in mouse hearts lacking the Hand2 transcription factor gene.

D. Srivastava, B. Emanuel, Xiao Liu, 2002, Genomics.

The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation.

D. Srivastava, E. Olson, R. Harvey, 2001, Developmental biology.

The maternal X chromosome impairs cognition and accelerates brain aging through epigenetic modulation in female mice

D. Srivastava, B. Panning, Yu Huang, 2022, bioRxiv.

BRD4 orchestrates genome folding to promote neural crest differentiation

D. Srivastava, A. Padmanabhan, Rajan Jain, 2021, Nature Genetics.

Serum response factor orchestrates nascent sarcomerogenesis and silences the biomineralization gene program in the heart

D. Srivastava, Kathryn N. Ivey, R. Schwartz, 2008, Proceedings of the National Academy of Sciences.

A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart.

D. Srivastava, E. Olson, J. Richardson, 2000, Development.

Long telomeres protect against age-dependent cardiac disease caused by NOTCH1 haploinsufficiency

H. Blau, D. Srivastava, Sanjeev S. Ranade, 2017, The Journal of clinical investigation.

TBX1 Regulates Chondrocyte Maturation in the Spheno-occipital Synchondrosis

D. Srivastava, S. Shibata, H. Yanagisawa, 2020, Journal of dental research.

microRNA-1 regulates sarcomere formation and suppresses smooth muscle gene expression in the mammalian heart

P. D. de Jong, D. Srivastava, Yen-Sin Ang, 2013, eLife.

Notch Post-Translationally Regulates β-Catenin Protein in Stem and Progenitor Cells

Chulan Kwon, D. Srivastava, I. N. King, 2011, Nature Cell Biology.

A common cis-acting sequence in the DiGeorge critical region regulates bi-directional transcription of UFD1L and CDC45L

D. Srivastava, Kathryn N. Ivey, V. Garg, 2001, Mechanisms of Development.

Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors

Chulan Kwon, B. Conklin, D. Srivastava, 2007, Proceedings of the National Academy of Sciences.

A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafish

Joshua D. Wythe, B. Bruneau, D. Srivastava, 2011, Development.

A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme.

D. Srivastava, Y. Yazaki, E. Olson, 1998, Development.

A Regulatory Pathway Involving Notch1/β-Catenin/Isl1 Determines Cardiac Progenitor Cell Fate

Chulan Kwon, D. Srivastava, Joshua Arnold, 2009, Nature Cell Biology.

Potential of stem-cell-based therapies for heart disease

D. Srivastava, Kathryn N. Ivey, Kathryn N Ivey, 2006, Nature.

The E3 ubiquitin ligase Nedd4/Nedd4L is directly regulated by microRNA 1

D. Srivastava, Kathryn N. Ivey, I. S. Kathiriya, 2017, Development.

Association of Damaging Variants in Genes With Increased Cancer Risk Among Patients With Congenital Heart Disease

W. Chung, J. Seidman, Yufeng Shen, 2020, JAMA cardiology.

Altered microRNAs in bicuspid aortic valve: a comparison between stenotic and insufficient valves.

D. Srivastava, B. Jensen, P. Simpson, 2010, The Journal of heart valve disease.

skNAC, a Smyd1-interacting transcription factor, is involved in cardiac development and skeletal muscle growth and regeneration

H. Blau, D. Srivastava, Kathryn N. Ivey, 2010, Proceedings of the National Academy of Sciences.

Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease

D. Srivastava, Sanjeev S. Ranade, A. Malashicheva, 2020, Science.

Cardiac repair with thymosin β4 and cardiac reprogramming factors

D. Srivastava, M. Ieda, Ji-Dong Fu, 2012, Annals of the New York Academy of Sciences.

Molecular Mechanisms Regulating Tissue-Specific Expression of Tbx1

D. Srivastava, H. Yamagishi, 2007 .

AKAP13 Rho-GEF and PKD-Binding Domain Deficient Mice Develop Normally but Have an Abnormal Response to β-Adrenergic-Induced Cardiac Hypertrophy

B. Conklin, D. Srivastava, E. Hsiao, 2013, PloS one.

Small solutions to big problems: microRNAs for cardiac regeneration.

D. Srivastava, A. Heidersbach, 2013, Circulation research.

Effect of biophysical cues on reprogramming to cardiomyocytes.

D. Srivastava, Song Li, Pengzhi Yu, 2016, Biomaterials.

Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species

Joshua D. Wythe, B. Bruneau, D. Srivastava, 2011, The Journal of cell biology.

Fibronectin mediates mesendodermal cell fate decisions

Chulan Kwon, D. Srivastava, B. Kaynak, 2013, Journal of Cell Science.

Premature MicroRNA-1 Expression Causes Hypoplasia of the Cardiac Ventricular Conduction System

V. Vedantham, Yong Zhao, Eva Samal, 2019, Front. Physiol..

Spectrum of heart disease associated with murine and human GATA4 mutation.

Karl W Broman, Deepak Srivastava, Ani Manichaikul, 2007, Journal of molecular and cellular cardiology.

Nonlinear imaging study of extracellular matrix in chemical-induced, developmental dissecting aortic aneurysm: evidence for defective collagen type III.

D. Srivastava, P. Boor, B. Gong, 2008, Birth defects research. Part A, Clinical and molecular teratology.

Tbx1 is regulated by forkhead proteins in the secondary heart field †

D. Srivastava, J. McAnally, J. Maeda, 2006, Developmental dynamics : an official publication of the American Association of Anatomists.

The bHLH factors, dHAND and eHAND, specify pulmonary and systemic cardiac ventricles independent of left-right sidedness.

D. Srivastava, E. Olson, P. Overbeek, 1998, Developmental biology.

Segmental Regulation of Cardiac Development by the Basic Helix-Loop-Helix Transcription Factors dHAND and eHAND

D. Srivastava, 1999 .

HAND proteins: molecular mediators of cardiac development and congenital heart disease.

D. Srivastava, 1999, Trends in cardiovascular medicine.

Knowing in your heart what's right.

D. Srivastava, E. Olson, E N Olson, 1997, Trends in cell biology.

Conservation of sequence and expression of Xenopus and zebrafish dHAND during cardiac, branchial arch and lateral mesoderm development

D. Srivastava, H. Yost, R. Breitbart, 2000, Mechanisms of Development.

Identification of GATA6 Sequence Variants in Patients With Congenital Heart Defects

D. Srivastava, V. Garg, S. Koenig, 2010, Pediatric Research.

Identification of GATA6 sequence variants in patients with congenital heart defects.

D. Srivastava, V. Garg, S. Koenig, 2010, Pediatric research.

Smyd1 Facilitates Heart Development by Antagonizing Oxidative and ER Stress Responses

Haley O. Tucker, D. Srivastava, R. Schwartz, 2015, PloS one.

Congenital heart defects: trapping the genetic culprits.

D. Srivastava, 2000, Circulation research.

An oligogenic inheritance test detects risk genes and their interactions in congenital heart defects and developmental comorbidities

K. Pollard, D. Srivastava, Kihyun Lee, 2022, bioRxiv.

D. Srivastava, E. Hsiao, S. A. Wong, 2016, Stem Cell Research & Therapy.

Alternative induced pluripotent stem cell characterization criteria for in vitro applications.

Peter W Zandstra, Deepak Srivastava, Janet Rossant, 2009, Cell stem cell.

BRD4 (Bromodomain-Containing Protein 4) Interacts with GATA4 (GATA Binding Protein 4) to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes

Saptarsi M. Haldar, D. Srivastava, A. Padmanabhan, 2020 .

Systems Analysis Implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects

Nicolas F. Fernandez, W. Chung, D. Srivastava, 2020, JACC. Basic to translational science.

Sarcomeres and Cardiac Growth: Tension in the Relationship.

Saptarsi M. Haldar, D. Srivastava, 2016, Trends in molecular medicine.

Chromatin Remodeling Drives Immune-Fibroblast Crosstalk in Heart Failure Pathogenesis

Saptarsi M. Haldar, K. Pollard, D. Srivastava, 2023, bioRxiv.

The E3 ubiquitin ligase Nedd4/Nedd4L is directly regulated by microRNA 1

D. Srivastava, Kathryn N. Ivey, I. S. Kathiriya, 2017, Journal of Cell Science.

RNA sequencing of mouse sinoatrial node reveals an upstream regulatory role for Islet-1 in cardiac pacemaker cells.

Rahul C. Deo, V. Vedantham, D. Srivastava, 2015, Circulation research.

Direct reprogramming of fibroblasts into cardiomyocytes for cardiac regenerative medicine.

D. Srivastava, Ji-Dong Fu, 2015, Circulation journal : official journal of the Japanese Circulation Society.

Genomic analyses implicate noncoding de novo variants in congenital heart disease

Gabor T. Marth, Kathleen M. Chen, K. B. Manheimer, 2020, Nature Genetics.

Single-cell transcriptome analysis during cardiogenesis reveals basis for organ level developmental anomalies

A. del Sol, D. Srivastava, Sanjeev S. Ranade, 2018, bioRxiv.

Oligogenic inheritance of congenital heart disease involving a NKX2-5 modifier

D. Srivastava, S. Wyman, Kathryn N. Ivey, 2018, bioRxiv.

The RNA-binding Protein TDP-43 Selectively Disrupts MicroRNA-1/206 Incorporation into the RNA-induced Silencing Complex*♦

D. Srivastava, Kathryn N. Ivey, D. M. Ando, 2014, The Journal of Biological Chemistry.

The RNA-binding Protein TDP-43 Selectively Disrupts MicroRNA-1/206 Incorporation into the RNA-induced

D. Srivastava, Kathryn N. Ivey, D. M. Ando, 2014 .

Thymosin beta4 is cardioprotective after myocardial infarction.

D. Srivastava, A. Saxena, J. Michael DiMaio, 2007, Annals of the New York Academy of Sciences.

Oligogenic Architecture of Rare Noncoding Variants Distinguishes 4 Congenital Heart Disease Phenotypes

K. Pollard, Matthew Aguirre, J. Priest, 2023, Circulation. Genomic and precision medicine.

Hand Transcription Factors

D. Srivastava, E. Olson, 2002 .

Transcriptional Regulation of Ventricular Morphogenesis

D. Srivastava, 2007 .

A transcriptional pathway for cardiac development.

D. Srivastava, E. Olson, Q. Lin, 1997, Cold Spring Harbor Symposia on Quantitative Biology.

Contribution of Previously Unrecognized RNA Splice-Altering Variants to Congenital Heart Disease

Parth N. Patel, J. Seidman, Yufeng Shen, 2023, Circulation. Genomic and precision medicine.

EM-mosaic detects mosaic point mutations that contribute to congenital heart disease

K. B. Manheimer, W. Chung, J. Seidman, 2020, Genome Medicine.

Left-right asymmetry and cardiac looping: implications for cardiac development and congenital heart disease.

D. Srivastava, I. S. Kathiriya, D. Srivastava, 2000, American journal of medical genetics.

A Long Non-Coding RNA Defines an Epigenetic Checkpoint in Cardiac Hypertrophy

D. Srivastava, Yen-Sin Ang, X. Xiao, 2016, Nature Medicine.

Sonic Hedgehog Is Essential for First Pharyngeal Arch Development

D. Srivastava, Kathryn N. Ivey, T. Tsuchihashi, 2006, Pediatric Research.

Dynamic and Coordinated Epigenetic Regulation of Developmental Transitions in the Cardiac Lineage

Alexander R. Pico, Genevieve D. Erwin, K. Pollard, 2012, Cell.

A Regulatory Pathway Involving Notch1/β-Catenin/Isl1 Determines Cardiac Progenitor Cell Fate

Chulan Kwon, D. Srivastava, Joshua Arnold, 2009, Nature Cell Biology.

Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling.

D. Srivastava, Kathryn N. Ivey, R. Ross, 2009, Developmental cell.

Direct Cardiac Reprogramming From Developmental Biology to Cardiac Regeneration

D. Srivastava, Li Qian, 2013 .

Direct Cardiac Reprogramming From Developmental Biology to Cardiac Regeneration

D. Srivastava, Li Qian, 2013 .

MicroRNA regulation of cardiovascular development.

D. Srivastava, Kimberly R. Cordes, 2009, Circulation research.

A Long Non-Coding RNA Defines an Epigenetic Checkpoint in Cardiac Hypertrophy

D. Srivastava, Yen-Sin Ang, X. Xiao, 2016, Nature Medicine.

Long telomeres protect against age-dependent cardiac disease caused by NOTCH1 haploinsufficiency

H. Blau, D. Srivastava, Sanjeev S. Ranade, 2017, The Journal of clinical investigation.

The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling

D. Srivastava, Sangho Yu, Dianna M. Crawford, 2011, Developmental dynamics : an official publication of the American Association of Anatomists.

Thymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair

D. Srivastava, J. DiMaio, A. Saxena, 2004, Nature.

Limited Gene Expression Variation in Human Embryonic Stem Cell and Induced Pluripotent Stem Cell‐Derived Endothelial Cells

D. Srivastava, Kathryn N. Ivey, J. Cooke, 2013, Stem cells.

MicroRNAs as regulators of differentiation and cell fate decisions.

D. Srivastava, Kathryn N. Ivey, 2010, Cell stem cell.

Abstract 10466: In Vivo Reprogramming of Murine Cardiac Fibroblasts into Induced Cardiomyocytes

D. Srivastava, Ji-Dong Fu, Yu Huang, 2011, Circulation.

Thymosin β4 and cardiac repair

D. Srivastava, E. Olson, Santwana Shrivastava, 2010, Annals of the New York Academy of Sciences.

A Rare Human Sequence Variant Reveals Myocardin Autoinhibition*♦

D. Srivastava, V. Garg, J. Ransom, 2008, Journal of Biological Chemistry.

BRD4 Interacts with GATA4 to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes.

Saptarsi M. Haldar, D. Srivastava, A. Padmanabhan, 2020, Circulation.

De Novo Mutations in Histone-Modifying Genes in Congenital Heart Disease Congenital Heart Disease Entering a New Era of Human Genetics Commentaries on Cutting Edge Science

B. Bruneau, D. Srivastava, 2014 .

Comparative analysis of diverse cell states establishes an epigenetic basis for inferring regulatory genes governing cell identity

Yuliang, M. Bodén, D. Srivastava, 2019 .

Loss of Tbx1 induces bone phenotypes similar to cleidocranial dysplasia.

D. Srivastava, J. Richardson, Masataka Nakamura, 2015, Human molecular genetics.

Mouse gastruloids take heart

D. Srivastava, T. McDevitt, 2021, Nature Reviews Cardiology.

Heart disease: An ongoing genetic battle?

D. Srivastava, 2004, Nature.