P. MacDonald

发表

A pancreatic islet-specific microRNA regulates insulin secretion

N. Rajewsky, M. N. Poy, M. Stoffel, 2004, Nature.

Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells.

P. Neufer, P. MacDonald, A. Gloyn, 2015, The Journal of clinical investigation.

N-acyl Taurines and Acylcarnitines Cause an Imbalance in Insulin Synthesis and Secretion Provoking β Cell Dysfunction in Type 2 Diabetes.

Na Sun, Theodore Alexandrov, Jan Krumsiek, 2017, Cell metabolism.

Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors

Mark I. McCarthy, Barbara E. Stranger, Emmanouil T. Dermitzakis, 2015, PLoS genetics.

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

Nathan A. Bihlmeyer, Sara M. Willems, Erica L. Kleinbrink, 2019, bioRxiv.

Stem cells to insulin secreting cells: two steps forward and now a time to pause?

P. MacDonald, J. Kushner, M. Atkinson, 2014, Cell stem cell.

Role of phosphatidylinositol 3-kinasegamma in the beta-cell: interactions with glucagon-like peptide-1.

P. MacDonald, G. Oudit, P. Brubaker, 2006, Endocrinology.

Pancreas patch-seq links physiologic dysfunction in diabetes to single-cell transcriptomic phenotypes

S. Quake, P. MacDonald, Y. Hang, 2019, bioRxiv.

Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion

P. MacDonald, N. Morgan, S. Richardson, 2020, Cell reports.

Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D

Stephen C. J. Parker, Anthony J. Payne, M. McCarthy, 2020, Nature Communications.

Vitamin D-binding protein is required for the maintenance of α-cell function and glucagon secretion

P. MacDonald, N. Morgan, S. Richardson, 2019, bioRxiv.

Influence of genetic variants on gene expression in human pancreatic islets – implications for type 2 diabetes

Stephen C. J. Parker, Anthony J. Payne, M. McCarthy, 2019, bioRxiv.

SUMO1 enhances cAMP‐dependent exocytosis and glucagon secretion from pancreatic α‐cells

P. MacDonald, X. Dai, A. Spigelman, 2014, The Journal of physiology.

Antagonism of Rat β-Cell Voltage-dependent K+ Currents by Exendin 4 Requires Dual Activation of the cAMP/Protein Kinase A and Phosphatidylinositol 3-Kinase Signaling Pathways*

P. MacDonald, E. Targonsky, M. Wheeler, 2003, Journal of Biological Chemistry.

Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules

James D. Johnson, B. Marsh, M. Hayden, 2011, Diabetes.

Kiss-and-run exocytosis and fusion pores of secretory vesicles in human β-cells

P. MacDonald, P. Rorsman, A. Clark, 2009, Pflügers Archiv - European Journal of Physiology.

The ins and outs of secretion from pancreatic beta-cells: control of single-vesicle exo- and endocytosis.

P. MacDonald, P. Rorsman, 2007, Physiology.

Calcium increases endocytotic vesicle size and accelerates membrane fission in insulin-secreting INS-1 cells

L. Eliasson, P. MacDonald, P. Rorsman, 2005, Journal of Cell Science.

Glucagon-like peptide 1 increases insulin sensitivity in depancreatized dogs.

P. MacDonald, M. Vranic, M. Wheeler, 1999, Diabetes.

Dichotomous role of pancreatic HUWE1/MULE/ARF-BP1 in modulating beta cell apoptosis in mice under physiological and genotoxic conditions

P. MacDonald, T. Mak, M. Woo, 2014, Diabetologia.

Chronic insulin infusion induces reversible glucose intolerance in lean rats yet ameliorates glucose intolerance in obese rats.

P. MacDonald, C. Soltys, P. Light, 2017, Biochimica et biophysica acta. General subjects.

Insulin granule recruitment and exocytosis is dependent on p 110 γ in insulinoma and human β-cells Running Title : PI 3 kinase-γ Regulates Granule Localization

P. MacDonald, M. Woo, J. M. Fox, 2009 .

Antiaging Glycopeptide Protects Human Islets Against Tacrolimus-Related Injury and Facilitates Engraftment in Mice

P. MacDonald, J. E. Manning Fox, A. Shapiro, 2015, Diabetes.

A Glycine-Insulin Autocrine Feedback Loop Enhances Insulin Secretion From Human β-Cells and Is Impaired in Type 2 Diabetes

P. MacDonald, M. Ferdaoussi, X. Dai, 2016, Diabetes.

Decreased STARD 10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice

William W. Greenwald, Kyle J. Gaulton, M. McCarthy, 2017 .

Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding

P. MacDonald, A. Gloyn, M. Ferdaoussi, 2022, bioRxiv.

From Isles of Königsberg to Islets of Langerhans: Examining the Function of the Endocrine Pancreas Through Network Science

P. MacDonald, M. Gosak, A. Stožer, 2022, Frontiers in Endocrinology.

STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation

P. MacDonald, K. Hoehn, J. M. Fox, 2017, Endocrine.

Converting Adult Pancreatic Islet a Cells into b Cells by Targeting Both Dnmt 1 and Arx Graphical Abstract Highlights

P. MacDonald, P. Herrera, M. Enge, 2018 .

Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression

Jason M. Torres, P. MacDonald, A. Mahajan, 2022, bioRxiv.

Impacts of the COVID-19 pandemic on a human research islet program

P. MacDonald, Nancy Smith, A. Spigelman, 2021, bioRxiv.

Inhibition of Kv2.1 Voltage-dependent K+Channels in Pancreatic β-Cells Enhances Glucose-dependent Insulin Secretion*

Catherine B. Chan, P. MacDonald, G. Sakellaropoulos, 2002, The Journal of Biological Chemistry.

Splice variant-dependent regulation of beta-cell sodium-calcium exchange by acyl-coenzyme As.

P. MacDonald, P. Light, M. J. Riedel, 2008, Molecular endocrinology.

Insulin Secretion Induced by Glucose-dependent Insulinotropic Polypeptide Requires Phosphatidylinositol 3-Kinase γ in Rodent and Human β-Cells*

P. MacDonald, A. Spigelman, J. E. Manning Fox, 2014, The Journal of Biological Chemistry.

Per-arnt-sim (PAS) domain kinase (PASK) as a regulator of glucagon secretion

P. MacDonald, P. Rorsman, Patrik Rorsman, 2011, Diabetologia.

Role of Kinin B2 Receptor Signaling in the Recruitment of Circulating Progenitor Cells With Neovascularization Potential

G. Angelini, P. MacDonald, J. Schanstra, 2008, Circulation research.

Mutations to the third cytoplasmic domain of the glucagon-like peptide 1 (GLP-1) receptor can functionally uncouple GLP-1-stimulated insulin secretion in HIT-T15 cells.

P. MacDonald, M. Wheeler, A. Salapatek, 1999, Molecular endocrinology.

NFIA regulates granule recruitment and exocytosis in the adult pancreas

Matthew C. Hill, S. Quake, P. MacDonald, 2019, bioRxiv.

SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells.

P. MacDonald, P. Rorsman, A. Gloyn, 2012, American journal of physiology. Endocrinology and metabolism.

Distinct and opposing roles for the phosphatidylinositol 3-OH kinase catalytic subunits p110α and p110β in the regulation of insulin secretion from rodent and human beta cells

P. MacDonald, C. Hajmrle, A. Spigelman, 2013, Diabetologia.

Control of secretory granule access to the plasma membrane by PI3 kinase-γ

P. MacDonald, 2009, Islets.

The phosphatidylinositol 3‐kinase inhibitor LY294002 potently blocks Kv currents via a direct mechanism

P. MacDonald, P. Light, M. Wheeler, 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A role for PKD1 in insulin secretion downstream of P2Y1 receptor activation in mouse and human islets

P. MacDonald, M. Ferdaoussi, Nancy Smith, 2019, Physiological reports.

Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets.

P. MacDonald, E. Marbán, C. Chan, 1999, Diabetes.

SSTR2 is the functionally dominant somatostatin receptor in human pancreatic (cid:1) - and (cid:2) -cells

P. MacDonald, P. Rorsman, A. Gloyn, 2012 .

cAMP-independent effects of GLP-1 on β cells.

P. MacDonald, J. Kolic, Jelena Kolic, 2015, The Journal of clinical investigation.

Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in Pancreatic β-Cells

P. MacDonald, J. Stieber, M. Wheeler, 2007 .

Type 2 Diabetes Risk Alleles Reveal a Role for Peptidylglycine Alpha-amidating Monooxygenase in Beta Cell Function

C. Groves, P. MacDonald, P. Rorsman, 2017, bioRxiv.

Novel mouse model expands potential human α-cell research

P. MacDonald, Theodore Dos Santos, 2021, Islets.

HNF1α transcriptional activation and repression maintain human islet α and β cell function

P. MacDonald, Xueying Gu, Seung K. Kim, 2022, bioRxiv.

Aging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress

Galina A. Erikson, P. MacDonald, M. Hetzer, 2022, Science advances.

Characterization of Erg K+ Channels in α- and β-Cells of Mouse and Human Islets*

P. MacDonald, A. Gyulkhandanyan, M. Wheeler, 2009, The Journal of Biological Chemistry.

In Vivo Role of Focal Adhesion Kinase in Regulating Pancreatic β-Cell Mass and Function Through Insulin Signaling, Actin Dynamics, and Granule Trafficking

P. MacDonald, X. Dai, C. Hajmrle, 2012, Diabetes.

Glucagon-like peptide-1 receptor activation antagonizes voltage-dependent repolarizing K(+) currents in beta-cells: a possible glucose-dependent insulinotropic mechanism.

P. MacDonald, M. Wheeler, A. Salapatek, 2002, Diabetes.

Synaptosome-associated protein of 25 kilodaltons modulates Kv2.1 voltage-dependent K(+) channels in neuroendocrine islet beta-cells through an interaction with the channel N terminus.

P. MacDonald, M. Wheeler, J. Lakey, 2002, Molecular endocrinology.

TRP-ing Down the Path to Insulin Secretion

P. MacDonald, 2011, Diabetes.

SARS-CoV-2 infects cells of the human exocrine and endocrine pancreas and interferes with beta-cell function

A. Stenzinger, J. Gehrmann, P. MacDonald, 2020 .

Temperature and redox state dependence of native Kv2.1 currents in rat pancreatic β‐cells

P. MacDonald, M. Wheeler, A. Salapatek, 2003, The Journal of physiology.

TCF 1 links GIPR signaling to the control of beta cell function and survival

C. Streutker, P. MacDonald, J. Wrana, 2015 .

Members of the Kv1 and Kv2 voltage-dependent K(+) channel families regulate insulin secretion.

P. MacDonald, M. Wheeler, P. Backx, 2001, Molecular endocrinology.

The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function

P. MacDonald, X. Dai, C. Hajmrle, 2012, Diabetologia.

Mitochondrial Metabolism of Pyruvate Is Essential for Regulating Glucose-stimulated Insulin Secretion*

P. MacDonald, J. E. Manning Fox, J. Joseph, 2014, The Journal of Biological Chemistry.

Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells

Anthony J. Payne, M. McCarthy, C. Groves, 2018, Nature Genetics.

Improvement of islet transplantation by the fusion of islet cells with functional blood vessels

P. MacDonald, Emmanuel Ampofo, C. Götz, 2020, EMBO molecular medicine.

Deletion of carboxypeptidase E in beta cells disrupts proinsulin processing and alters beta cell identity in mice

P. MacDonald, W. Qian, X. Dai, 2022, bioRxiv.

Transplantation of Human Pancreatic Endoderm Cells Reverses Diabetes Post Transplantation in a Prevascularized Subcutaneous Site

P. MacDonald, A. Shapiro, T. Kin, 2017, Stem cell reports.

Loss of tetraspanin‐7 expression reduces pancreatic β‐cell exocytosis Ca2+ sensitivity but has limited effect on systemic metabolism

P. MacDonald, A. Spigelman, J. E. Manning Fox, 2022, Diabetic medicine : a journal of the British Diabetic Association.

KATP-channels and glucose-regulated glucagon secretion

P. MacDonald, P. Rorsman, F. Abdulkader, 2008, Trends in Endocrinology & Metabolism.

LKB1 couples glucose metabolism to insulin secretion in mice

B. Faubert, Russell G. Jones, P. MacDonald, 2015, Diabetologia.

Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways.

P. MacDonald, E. Targonsky, M. Wheeler, 2003, The Journal of biological chemistry.

A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk

P. MacDonald, A. Gloyn, Seung K. Kim, 2022, Nature Genetics.

Triton X‐100 inhibits L‐type voltage‐operated calcium channels

P. MacDonald, P. Light, A. Holt, 2012, Canadian journal of physiology and pharmacology.

Corelease and Differential Exit via the Fusion Pore of GABA, Serotonin, and ATP from LDCV in Rat Pancreatic β Cells

P. MacDonald, P. Rorsman, A. Clark, 2007, The Journal of general physiology.

Glucose-sensing mechanisms in pancreatic β-cells

Patrik Rorsman, P. MacDonald, P. Rorsman, 2005, Philosophical Transactions of the Royal Society B: Biological Sciences.

Voltage-dependent K+ channels in pancreatic beta cells: Role, regulation and potential as therapeutic targets

P. MacDonald, M. Wheeler, 2003, Diabetologia.

P2Y1 purinergic receptor identified as a diabetes target in a small-molecule screen to reverse circadian β-cell failure

P. MacDonald, J. E. Manning Fox, J. Bass, 2022, eLife.

Pharmacologic rescue of circadian β-cell failure through P2Y1 purinergic receptor identified by small-molecule screen

P. MacDonald, J. Bass, J. M. Fox, 2021 .

SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas

A. Stenzinger, J. Gehrmann, P. MacDonald, 2021, Nature Metabolism.

SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human ß cells

P. MacDonald, M. Ferdaoussi, X. Dai, 2017, Scientific Reports.

Toward Connecting Metabolism to the Exocytotic Site.

P. MacDonald, M. Ferdaoussi, 2017, Trends in cell biology.

Integration of single-cell multiomic measurements across disease states with genetics identifies mechanisms of beta cell dysfunction in type 2 diabetes

Kyle J. Gaulton, P. MacDonald, Y. Hang, 2023, bioRxiv.

The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion.

Michael B Wheeler, P. MacDonald, P. Light, 2002, Diabetes.

Loss of mTORC1 signaling alters pancreatic &agr; cell mass and impairs glucagon secretion

P. MacDonald, E. Bernal-Mizrachi, M. Blandino-Rosano, 2017, The Journal of clinical investigation.

Heterogenous impairment of α-cell function in type 2 diabetes is linked to cell maturation state

Robert C. Jones, S. Quake, P. MacDonald, 2021, bioRxiv.

A New Hypothesis for Type 1 Diabetes Risk: The At-Risk Allele at rs3842753 Associates With Increased Beta-cell INS Messenger RNA in a Meta-Analysis of Single-Cell RNA-Sequencing Data.

James D. Johnson, P. MacDonald, S. Flibotte, 2021, Canadian journal of diabetes.

Molecular and functional profiling of human islets: from heterogeneity to human phenotypes

P. MacDonald, Rafael Arrojo e Drigo, Birbickram Roy, 2020, Diabetologia.

Patch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes.

S. Quake, P. MacDonald, Y. Hang, 2020, Cell metabolism.

Aging of human endocrine pancreatic cell types is heterogeneous and sex-specific

Galina A. Erikson, P. MacDonald, M. Hetzer, 2019, bioRxiv.

A KATP Channel-Dependent Pathway within α Cells Regulates Glucagon Release from Both Rodent and Human Islets of Langerhans

L. Eliasson, Xiaosong Ma, P. MacDonald, 2007, PLoS biology.

Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx.

S. Quake, P. MacDonald, Harini Chakravarthy, 2017, Cell metabolism.

Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance

James D. Johnson, P. MacDonald, C. Nislow, 2022, Nature Communications.

Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance

James D. Johnson, P. MacDonald, C. Nislow, 2020, Nature communications.

Cryopreservation and post-thaw characterization of dissociated human islet cells

P. MacDonald, Y. Hang, Seung K. Kim, 2022, PloS one.

A new hypothesis for type 1 diabetes risk: The at-risk allele at rs3842753 associates with increased beta cell INS mRNA in a meta-analysis of single cell RNA sequencing data

James D. Johnson, P. MacDonald, S. Flibotte, 2020, bioRxiv.

A role for alternative splicing in circadian control of exocytosis and glucose homeostasis

Gene W. Yeo, P. MacDonald, J. Bass, 2020, Genes & development.

Investigation of Transport Mechanisms and Regulation of Intracellular Zn2+ in Pancreatic α-Cells*

P. MacDonald, F. Dai, A. Gyulkhandanyan, 2008, Journal of Biological Chemistry.

Urea impairs β cell glycolysis and insulin secretion in chronic kidney disease.

P. MacDonald, X. Dai, J. E. Manning Fox, 2016, The Journal of clinical investigation.

PI3 kinases p110α and PI3K-C2β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets

P. MacDonald, M. Ferdaoussi, A. Spigelman, 2016, Molecular metabolism.

Beta-cell specific insulin resistance promotes glucose-stimulated insulin hypersecretion

James D. Johnson, P. MacDonald, C. Nislow, 2020, bioRxiv.

Novel roles of SUMO in pancreatic β-cells: thinking outside the nucleus.

P. MacDonald, C. Hajmrle, J. E. Manning Fox, 2012, Canadian journal of physiology and pharmacology.

Interleukin-1 signaling contributes to acute islet compensation.

P. MacDonald, M. Ferdaoussi, X. Dai, 2016, JCI insight.

Metabolic Messengers: glucagon

P. MacDonald, P. Rorsman, 2023, Nature Metabolism.

Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion.

P. MacDonald, J. E. Manning Fox, Xiaodong Cheng, 2015, Molecular endocrinology.

Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes

Lisa J. Mellander, P. MacDonald, P. Rorsman, 2020, bioRxiv.

Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice

Philippe Froguel, Mario Falchi, William W. Greenwald, 2017, American journal of human genetics.

Research-Focused Isolation of Human Islets From Donors With and Without Diabetes at the Alberta Diabetes Institute IsletCore.

P. MacDonald, A. Spigelman, J. E. Manning Fox, 2016, Endocrinology.

Human islet function following 20 years of cryogenic biobanking

M. McCarthy, P. MacDonald, A. Gloyn, 2015, Diabetologia.

Cystic fibrosis-related diabetes is caused by islet loss and inflammation.

M. Drumm, W. Bush, P. MacDonald, 2018, JCI insight.

The cell biology of systemic insulin function

P. MacDonald, A. Klip, Amira Klip, 2018, The Journal of cell biology.

Inhibition of β-Cell Sodium-Calcium Exchange Enhances Glucose-Dependent Elevations in Cytoplasmic Calcium and Insulin Secretion

P. MacDonald, P. Light, X. Dai, 2010, Diabetes.

GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration

P. MacDonald, D. Egli, Kunal Kumar, 2020, Science Translational Medicine.

SUMOylation Regulates Insulin Exocytosis Downstream of Secretory Granule Docking in Rodents and Humans

P. MacDonald, X. Dai, C. Hajmrle, 2011, Diabetes.

SUMOylation regulates Kv2.1 and modulates pancreatic β-cell excitability

P. MacDonald, X. Dai, S. Sipione, 2009, Journal of Cell Science.

CRISPR-based genome editing in primary human pancreatic islet cells

Antonia A. Dominguez, Lei S. Qi, P. MacDonald, 2021, Nature Communications.

Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction

P. MacDonald, X. Dai, M. Jensen, 2017, Diabetes.

β-cell responses to high fat feeding: A role and mechanism for redox sensing by SENP1

P. MacDonald, M. Ferdaoussi, X. Dai, 2023, bioRxiv.

β-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High-Fat Diet–Fed Mice

P. MacDonald, M. Ferdaoussi, Nancy Smith, 2021, Diabetes.

Combinatorial transcription factor profiles predict mature and functional human islet α and β cells

Stephen C. J. Parker, Diane C. Saunders, P. MacDonald, 2021, bioRxiv.

Impaired “Glycine”-mia in Type 2 Diabetes and Potential Mechanisms Contributing to Glucose Homeostasis

P. MacDonald, Richard Yan-Do, 2017, Endocrinology.

Signal integration at the level of ion channel and exocytotic function in pancreatic β-cells.

P. MacDonald, 2011, American journal of physiology. Endocrinology and metabolism.

A glucose-dependent spatial patterning of exocytosis in human β-cells is disrupted in type 2 diabetes

P. MacDonald, X. Dai, A. Spigelman, 2019, bioRxiv.

A glucose-dependent spatial patterning of exocytosis in human β-cells is disrupted in type 2 diabetes

P. MacDonald, X. Dai, A. Spigelman, 2019, bioRxiv.

β-cell SENP1 facilitates responsiveness to incretins and limits oral glucose intolerance in high fat fed mice

P. MacDonald, M. Ferdaoussi, Nancy Smith, 2020, bioRxiv.

Metabolomics applied to islet nutrient sensing mechanisms

P. MacDonald, M. Ferdaoussi, X. Dai, 2017, Diabetes, obesity & metabolism.

TCF1 links GIPR signaling to the control of beta cell function and survival

C. Streutker, P. MacDonald, J. Wrana, 2015, Nature Medicine.

FK506-Binding Protein 2 Participates in Proinsulin Folding

P. MacDonald, P. Hägglund, M. Puglia, 2022, bioRxiv.

Intraislet SLIT–ROBO signaling is required for beta-cell survival and potentiates insulin secretion

James D. Johnson, P. MacDonald, J. E. Manning Fox, 2013, Proceedings of the National Academy of Sciences.

Release of small transmitters through kiss-and-run fusion pores in rat pancreatic beta cells.

P. MacDonald, P. Rorsman, J. Galvanovskis, 2006, Cell metabolism.

Controlling insulin secretion: an exciting TASK.

P. MacDonald, 2014, Endocrinology.

Improved glucose tolerance with DPPIV inhibition requires β‐cell SENP1 amplification of glucose‐stimulated insulin secretion

P. MacDonald, M. Ferdaoussi, X. Dai, 2020, Physiological reports.

Voltage-dependent K+ channels are positive regulators of alpha cell action potential generation and glucagon secretion in mice and humans

P. MacDonald, X. Dai, A. Spigelman, 2010, Diabetologia.

Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism.

P. MacDonald, M. Ferdaoussi, X. Dai, 2015, Cell reports.

Oscillations, Intercellular Coupling, and Insulin Secretion in Pancreatic β Cells

P. MacDonald, P. Rorsman, 2006, PLoS biology.

Glucagon secretion and signaling in the development of diabetes

P. MacDonald, M. Vranic, H. Gaisano, 2012, Front. Physio..

Yield, cell composition, and function of islets isolated from different ages of neonatal pigs

P. MacDonald, A. Spigelman, R. Rajotte, 2022, Frontiers in Endocrinology.

β Cell tone is defined by proglucagon peptides through cAMP signaling.

P. MacDonald, D. D’Alessio, Jonathan E. Campbell, 2019, JCI insight.

Autocrine activation of P2Y1 receptors couples Ca2+ influx to Ca2+ release in human pancreatic beta cells

P. MacDonald, S. Cheley, Xichen Wu, 2014, Diabetologia.

G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1

P. MacDonald, M. Prentki, E. Olson, 2012, Diabetologia.

Type 2 Diabetes Risk Alleles Reveal a Role for Peptidylglycine Alpha-amidating Monooxygenase in Beta Cell Function

C. Groves, P. MacDonald, P. Rorsman, 2017, bioRxiv.

Integrating genetics with single-cell multiomic measurements across disease states identifies mechanisms of beta cell dysfunction in type 2 diabetes

Kyle J. Gaulton, P. MacDonald, Y. Hang, 2023, Nature Genetics.

Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state.

Robert C. Jones, S. Quake, K. Kaestner, 2022, Cell metabolism.

Reduced expression of the co-regulator TLE1 in type 2 diabetes is associated with increased islet α-cell number.

P. MacDonald, N. Krasnogor, N. Morgan, 2020, Endocrinology.

The role of the transcription factor ETV5 in insulin exocytosis

Jisoo Park, P. MacDonald, S. Woods, 2014, Diabetologia.

Multivesicular exocytosis in rat pancreatic beta cells

C. Genoud, L. Eliasson, P. MacDonald, 2011, Diabetologia.

AVP-induced counter-regulatory glucagon is diminished in type 1 diabetes

Lina Abdul Kadir, Lisa J. Mellander, P. MacDonald, 2020 .

Impaired glucose-stimulated insulin secretion, enhanced intraperitoneal insulin tolerance, and increased beta-cell mass in mice lacking the p110gamma isoform of phosphoinositide 3-kinase.

P. MacDonald, J. Diao, F. Dai, 2004, Endocrinology.

Regulated exocytosis and kiss-and-run of synaptic-like microvesicles in INS-1 and primary rat beta-cells.

L. Eliasson, P. MacDonald, P. Rorsman, 2005, Diabetes.

Human islets contain a subpopulation of glucagon-like peptide-1 secreting α cells that is increased in type 2 diabetes

P. MacDonald, P. Light, K. Philippaert, 2020, Molecular metabolism.

Ca2+ oscillations, waves, and networks in islets from human donors with and without type 2 diabetes

P. MacDonald, M. Gosak, A. Stožer, 2021, bioRxiv.

DeSUMOylation Controls Insulin Exocytosis in Response to Metabolic Signals

P. MacDonald, X. Dai, G. Plummer, 2012, Biomolecules.

Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease

P. MacDonald, L. Foster, A. Gloyn, 2023, medRxiv.

A post-translational balancing act: the good and the bad of SUMOylation in pancreatic islets

P. MacDonald, 2018, Diabetologia.

SUMOylation protects against IL-1β-induced apoptosis in INS-1 832/13 cells and human islets.

P. MacDonald, M. Ferdaoussi, C. Hajmrle, 2014, American journal of physiology. Endocrinology and metabolism.

Insulin Granule Recruitment and Exocytosis Is Dependent on p110γ in Insulinoma and Human β-Cells

P. MacDonald, J. E. Manning Fox, M. Woo, 2009, Diabetes.

SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas

A. Stenzinger, J. Gehrmann, P. MacDonald, 2021, Nature Metabolism.

Complete Suspension Differentiation of Human Pluripotent Stem Cells into Pancreatic Islets Using Vertical Wheel® Bioreactors

P. MacDonald, J. Lyon, R. Pawlick, 2023, bioRxiv.

Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors

Kyle J. Gaulton, E. Dermitzakis, B. Stranger, 2015, PLoS genetics.

Caloric restriction promotes beta cell longevity and delays aging and senescence by enhancing cell identity and homeostasis mechanisms

T. Deerinck, Mark Ellisman, V. Lev-Ram, 2023, bioRxiv.