J. Frost

发表

Cdc42-interacting protein 4 promotes breast cancer cell invasion and formation of invadopodia through activation of N-WASp.

I. Pichot, C. Arvanitis, Sean M. Hartig, 2010, Cancer research.

Cross‐cascade activation of ERKs and ternary complex factors by Rho family proteins

Paul Shapiro, J. Frost, M. Cobb, 1997, The EMBO journal.

Cancer-Induced Muscle Wasting Requires p38β MAPK Activation of p300

J. Frost, Guohua Zhang, Yi-Ping Li, 2020, Cancer Research.

Real-Time Signaling Assays Demonstrate Somatostatin Agonist Bias for Ion Channel Regulation in Somatotroph Tumor Cells

J. Frost, A. Schonbrunn, Melissa Rodriguez, 2018, Journal of the Endocrine Society.

Persistent Pain after Spinal Cord Injury Is Maintained by Primary Afferent Activity

Max A. Odem, E. Walters, J. Frost, 2014, The Journal of Neuroscience.

Rapid transcriptional assay for the expression of two distinct reporter genes by microinjection.

J. Frost, A. Thorburn, A. Alberts, 1993, DNA and cell biology.

B-Raf and Raf-1 Are Regulated by Distinct Autoregulatory Mechanisms*

J. Frost, Xiaochong Wu, N. Tran, 2005, Journal of Biological Chemistry.

Activation of KCNQ Channels Prevents Paclitaxel-Induced Peripheral Neuropathy and Associated Neuropathic Pain.

J. Frost, Jinxiu Li, Y. Zuo, 2019, The journal of pain : official journal of the American Pain Society.

The highly conserved skb1 gene encodes a protein that interacts with Shk1, a fission yeast Ste20/PAK homolog.

J. Frost, M. Cobb, S. Marcus, 1996, Proceedings of the National Academy of Sciences of the United States of America.

A requirement for extracellular signal-regulated kinase (ERK) function in the activation of AP-1 by Ha-Ras, phorbol 12-myristate 13-acetate, and serum.

J. Frost, M. Cobb, J. Feramisco, 1994, Proceedings of the National Academy of Sciences of the United States of America.

The PDZ domain protein SYNJ2BP regulates GRK-dependent Sst2A phosphorylation and downstream MAPK signaling.

Jeffrey T. Chang, J. Frost, H. Carr, 2020, Endocrinology.

Regulation of the MAP kinase cascade.

J. Frost, M. Cobb, M. Hutchison, 1994, Cellular & molecular biology research.

Simian virus 40 small t antigen cooperates with mitogen-activated kinases to stimulate AP-1 activity

J. Frost, M. Mumby, K. Guan, 1994, Molecular and cellular biology.

Acetylation of the RhoA GEF Net1A controls its subcellular localization and activity

J. Frost, Y. Zuo, A. Ulu, 2015, Journal of Cell Science.

Differential Effects of PAK1-activating Mutations Reveal Activity-dependent and -independent Effects on Cytoskeletal Regulation*

J. Frost, M. White, M. Cobb, 1998, The Journal of Biological Chemistry.

KRAS Inhibitor that Simultaneously Inhibits Nucleotide Exchange Activity and Effector Engagement

J. Frost, Amit K. Gupta, C. Pagba, 2022, ACS Bio & Med Chem Au.

Regulation of Somatostatin Receptor 2 Trafficking by C-Tail Motifs and the Retromer

J. Frost, A. Bean, A. Ulu, 2019, Endocrinology.

Cdk1 phosphorylation negatively regulates the activity of Net1 towards RhoA during mitosis.

J. Frost, Y. Zuo, A. Ulu, 2021, Cellular signalling.

Stimulation of NFkappa B activity by multiple signaling pathways requires PAK1.

J. Frost, R. Gaynor, J. Swantek, 2000, The Journal of biological chemistry.

Phosphorylation of Human Jak3 at Tyrosines 904 and 939 Positively Regulates Its Activity

J. Frost, R. Kirken, J. Ross, 2008, Molecular and Cellular Biology.

PAK1 Negatively Regulates the Activity of the Rho Exchange Factor NET1*

J. Frost, H. Qin, A. Alberts, 2005, Journal of Biological Chemistry.

Minireview: Mouse Models of Rho GTPase Function in Mammary Gland Development, Tumorigenesis, and Metastasis.

J. Frost, Y. Zuo, A. Ulu, 2016, Molecular endocrinology.

c-Myc cooperates with activated Ras to induce the cdc2 promoter

J. Frost, G. Prendergast, A. Schönthal, 1994, Molecular and cellular biology.

Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338

M. H. Cobb, J. S. Brugge, J. A. Frost, 2000, Current Biology.

Timing is everything

J. Frost, H. Carr, 2013, Cell adhesion & migration.

Regulation of Focal Adhesion Kinase Activation, Breast Cancer Cell Motility, and Amoeboid Invasion by the RhoA Guanine Nucleotide Exchange Factor Net1

J. Frost, Y. Zuo, W. Oh, 2013, Molecular and Cellular Biology.

Regulation of RhoA activation and cell motility by c-Jun N-terminal kinases and Net1

J. Frost, A. Ulu, 2018, Small GTPases.

Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members

J. Frost, M. Cobb, Shuichan Xu, 1996, Molecular and cellular biology.

Activation of Mitogen-activated Protein Kinase Cascades by p21-activated Protein Kinases in Cell-free Extracts of Xenopus Oocytes (*)

J. Frost, A. Neiman, Peirong Yang, 1995, The Journal of Biological Chemistry.

Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity

D. Brenner, J. Frost, T. Hunter, 1992, Cell.

Stimulation of NFκB Activity by Multiple Signaling Pathways Requires PAK1*

J. Frost, R. Gaynor, J. Swantek, 2000, The Journal of Biological Chemistry.

The Monomeric G-Proteins Rac1 and/or Cdc42 Are Required for the Inhibition of Voltage-Dependent Calcium Current by Bradykinin

J. Frost, P. Sternweis, F. Belardetti, 1997, The Journal of Neuroscience.

p21-Activated Kinase 1 Plays a Critical Role in Cellular Activation by Nef

Oliver T. Fackler, Arthur S. Alberts, Matthias Geyer, 2000, Molecular and Cellular Biology.

Coexpression of α6β4 Integrin and Guanine Nucleotide Exchange Factor Net1 Identifies Node-Positive Breast Cancer Patients at High Risk for Distant Metastasis

W. Woodward, G. Fuller, J. Frost, 2009, Cancer Epidemiology Biomarkers & Prevention.

The RhoGEF Net1 is required for normal mammary gland development.

J. Frost, Y. Zuo, R. Berdeaux, 2014, Molecular endocrinology.

Contributions of the RhoA guanine nucleotide exchange factor Net1 to polyoma middle T antigen-mediated mammary gland tumorigenesis and metastasis

Jeffrey T. Chang, J. Frost, Y. Zuo, 2018, Breast Cancer Research.

Dasatinib synergizes with doxorubicin to block growth, migration, and invasion of breast cancer cells

C. Arvanitis, J. Frost, S. Corey, 2009, British Journal of Cancer.

The Nuclear RhoA Exchange Factor Net1 Interacts with Proteins of the Dlg Family, Affects Their Localization, and Influences Their Tumor Suppressor Activity

J. Frost, K. Burridge, R. García-Mata, 2007, Molecular and Cellular Biology.

Controlling the switches: Rho GTPase regulation during animal cell mitosis.

J. Frost, Y. Zuo, W. Oh, 2014, Cellular signalling.

Phosphorylation of Raf-1 by p21-activated Kinase 1 and Src Regulates Raf-1 Autoinhibition*

J. Frost, N. Tran, 2003, The Journal of Biological Chemistry.

Formation and Cell Spreading Factor Net1A To Regulate Focal Adhesion of the Rho Guanine Nucleotide Exchange Rac1 Controls the Subcellular Localization

J. Frost, C. Morris, S. Menon, 2013 .

Rac1 Controls the Subcellular Localization of the Rho Guanine Nucleotide Exchange Factor Net1A To Regulate Focal Adhesion Formation and Cell Spreading

J. Frost, C. Morris, S. Menon, 2012, Molecular and Cellular Biology.

MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase.

J. Frost, M. Cobb, Shuichan Xu, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Protein Phosphatase 2A Regulates Interleukin-2 Receptor Complex Formation and JAK3/STAT5 Activation*

J. Frost, Z. Nagy, R. Kirken, 2009, The Journal of Biological Chemistry.

Regulation of RhoA activation and cytoskeletal organization by acetylation

J. Frost, A. Ulu, 2016, Small GTPases.

Sphingomyelin Metabolism Is a Regulator of K-Ras Function

J. Frost, A. Naji, Dharini van der Hoeven, 2017, Molecular and Cellular Biology.

Mitogen-activated protein kinases mediate changes in gene expression, but not cytoskeletal organization associated with cardiac muscle cell hypertrophy

J. Frost, A. Thorburn, J. Thorburn, 1994, The Journal of cell biology.

Rho GTPase independent regulation of ATM activation and cell survival by the RhoGEF Net1A

J. Frost, W. Oh, Wonkyung Oh, 2014, Cell cycle.

Stress-activated MAPKs and CRM1 regulate the subcellular localization of Net1A to control cell motility and invasion

J. Frost, Y. Zuo, A. Ulu, 2018, Journal of Cell Science.

A Bacterial Cytotoxin Identifies the RhoA Exchange Factor Net1 as a Key Effector in the Response to DNA Damage

J. Frost, M. Masucci, T. Frisan, 2008, PloS one.

Scaffold repurposing of fendiline: Identification of potent KRAS plasma membrane localization inhibitors.

J. Frost, Na Ye, Dharini van der Hoeven, 2021, European journal of medicinal chemistry.

The Wnt pathway protein Dvl1 targets somatostatin receptor 2 for lysosome-dependent degradation

J. Frost, Y. Zuo, H. Carr, 2023, The Journal of biological chemistry.

Reciprocal Signaling between Heterotrimeric G Proteins and the p21-stimulated Protein Kinase*

J. Frost, Jun Wang, M. Cobb, 1999, The Journal of Biological Chemistry.

The MEK1 Proline-rich Insert Is Required for Efficient Activation of the Mitogen-activated Protein Kinases ERK1 and ERK2 in Mammalian Cells*

J. Frost, M. Cobb, A. Dang, 1998, The Journal of Biological Chemistry.

Activation of KCNQ Channels Suppresses Spontaneous Activity in Dorsal Root Ganglion Neurons and Reduces Chronic Pain after Spinal Cord Injury.

Qing Yang, Edgar T. Walters, E. Walters, 2017, Journal of neurotrauma.

Differential regulation of jun family gene expression by the tumor promoter okadaic acid.

J. Frost, A. Schönthal, J. Feramisco, 1991, The New biologist.

Interaction of the RhoA Exchange Factor Net1 with Discs Large Homolog 1 Protects It from Proteasome-mediated Degradation and Potentiates Net1 Activity*

J. Frost, K. Keinänen, H. Carr, 2009, The Journal of Biological Chemistry.

Characterization of the Biochemical and Transforming Properties of the Neuroepithelial Transforming Protein 1*

J. Frost, Xiaochong Wu, H. Qin, 2005, Journal of Biological Chemistry.

Src stimulates Abl-dependent phosphorylation of the guanine exchange factor Net1A to promote its cytosolic localization and cell motility

J. Frost, A. Ulu, H. Carr, 2023, The Journal of biological chemistry.

MEKK 1 phosphorylates MEK 1 and MEK 2 but does not cause activation of mitogen-activated protein kinase ( extracellular signal-related protein kinase / protein kinase cascades / Jun N-terminal kinase / stress-activated protein kinase )

J. Frost, M. Cobb, D. Robbins, 2005 .

Cancer esearch oenvironment and Immunology 42-Interacting Protein 4 Promotes Breast Cancer Cell sion and Formation of Invadopodia through R ivation of N-WASp

I. Pichot, C. Arvanitis, Sean M. Hartig, 2010 .

Rho GTPase–independent regulation of mitotic progression by the RhoGEF Net1

J. Frost, S. Menon, W. Oh, 2013, Molecular biology of the cell.

Contributions of the RhoA guanine nucleotide exchange factor Net1 to polyoma middle T antigen-mediated mammary gland tumorigenesis and metastasis

Jeffrey T. Chang, J. Frost, Y. Zuo, 2018, Breast Cancer Research.

Genetic deletion of the Rho GEF Net1 impairs mouse macrophage motility and actin cytoskeletal organization

J. Frost, A. Chauhan, Y. Zuo, 2020, Small GTPases.

Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity.

J. Frost, T. Hunter, M. Karin, 1992, Cell.

p21 activated kinase 5 activates Raf‐1 and targets it to mitochondria

J. Frost, Xiaochong Wu, Heather S Carr, 2008, Journal of cellular biochemistry.

Multiple Rho proteins regulate the subcellular targeting of PAK5.

J. Frost, Xiaochong Wu, 2006, Biochemical and biophysical research communications.

Acetylation of the RhoA GEF Net1A controls its subcellular localization and activity

J. Frost, Y. Zuo, A. Ulu, 2015, Journal of Cell Science.

Protein Phosphatase 2A Regulates Interleukin-2 Receptor Complex Formation and JAK3/STAT5 Activation*

J. Frost, Z. Nagy, R. Kirken, 2009, The Journal of Biological Chemistry.