Nanxin Li

发表

The Cancer Cell Line Encyclopedia enables predictive modeling of anticancer drug sensitivity

Adam A. Margolin, Michael P. Morrissey, S. Gabriel, 2012, Nature.

Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway

Michael Karin, Nanxin Li, Joseph Schlessinger, 1994, Cell.

Addendum: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

Adam A. Margolin, Michael P. Morrissey, S. Gabriel, 2012, Nature.

ATM Is Required for IκB Kinase (IKK) Activation in Response to DNA Double Strand Breaks*

G. Courtois, Y. Shiloh, Nanxin Li, 2000, The Journal of Biological Chemistry.

(R)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors.

Nanxin Li, Jennifer L. Harris, Jianwei Che, 2015, ACS medicinal chemistry letters.

TrkB inhibition by GNF-4256 slows growth and enhances chemotherapeutic efficacy in neuroblastoma xenografts

Nanxin Li, G. Brodeur, W. P. Gordon, 2014, Cancer Chemotherapy and Pharmacology.

Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models.

Nanxin Li, A. Kreusch, Shenlin Huang, 2012, ACS medicinal chemistry letters.

Oxidative stress and gene expression: The AP‐1 and NF‐κB connections

Nanxin Li, P. Kapahi, M. Karin, 2001 .

[25] Signaling pathways leading to nuclear factor-κB activation

Nanxin Li, M. Karin, 2000 .

Abstract 3790: Preclinical profile of LGX818: A potent and selective RAF kinase inhibitor

G. Caponigro, Nanxin Li, Edward G. Lorenzana, 2012 .

The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer.

Makoto Nishio, Peter McNamara, Ryohei Katayama, 2014, Cancer discovery.

Is NF‐κB the sensor of oxidative stress?

Michael Karin, Nanxin Li, Nanxin Li, 1999 .

Dual ALK and CDK4/6 Inhibition Demonstrates Synergy against Neuroblastoma

G. Caponigro, Nanxin Li, Jennifer L. Harris, 2016, Clinical Cancer Research.

BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein

Nanxin Li, C. Der, C. Bassing, 1993, Cell.

Signalling pathways: Kinase regulation in inflammatory response

Michael Karin, Nanxin Li, Nanxin Li, 2000, Nature.

Combined ALK and MDM2 inhibition increases antitumor activity and overcomes resistance in human ALK mutant neuroblastoma cell lines and xenograft models

W. Sellers, Nanxin Li, D. Ruddy, 2017, eLife.

Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain.

Glen Spraggon, Scott A Lesley, Nanxin Li, 2010, The Biochemical journal.

Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK

Peter G. Schultz, Yi Liu, Jiqing Jiang, 2007, Proceedings of the National Academy of Sciences.

Efficacy and Tolerability of Pyrazolo[1,5-a]pyrimidine RET Kinase Inhibitors for the Treatment of Lung Adenocarcinoma.

Nanxin Li, J. Shaffer, S. Kasibhatla, 2020, ACS medicinal chemistry letters.

Design and synthesis of novel selective anaplastic lymphoma kinase inhibitors.

Sungjoon Kim, Nanxin Li, Christian C. Lee, 2016, Bioorganic & Medicinal Chemistry Letters.

Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2

Sungjoon Kim, Nanxin Li, M. Warmuth, 2013, Journal of medicinal chemistry.

B-Raf kinase inhibitors for cancer treatment.

Nanxin Li, Nanxin Li, M. Warmuth, 2007, Current opinion in investigational drugs.

The function of GRB2 in linking the insulin receptor to Ras signaling pathways.

Nanxin Li, B. Margolis, J. Schlessinger, 1993, Science.

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

Nanxin Li, D. Bar-Sagi, B. Margolis, 1993, Nature.

Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms.

Nanxin Li, M. Karin, M Karin, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis

Nanxin Li, M. Jaye, J. Schlessinger, 1992, Nature.

SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high‐affinity binding site for SH2 domains of phospholipase C gamma.

A. Ullrich, Nanxin Li, B. Margolis, 1992, The EMBO journal.

The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC‐gamma.

T. Pawson, A. Ullrich, Nanxin Li, 1990, The EMBO journal.

Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain.

Sungjoon Kim, Nanxin Li, Jennifer L. Harris, 2010, The Biochemical journal.

Antitarget Selectivity and Tolerability of Novel Pyrrolo[2,3-d]pyrimidine RET Inhibitors.

Nanxin Li, J. Shaffer, S. Kasibhatla, 2021, ACS medicinal chemistry letters.