S. Jacob

发表

MicroRNA-221/222 Confers Tamoxifen Resistance in Breast Cancer by Targeting p27Kip1*♦

Tyler E. Miller, K. Ghoshal, B. Ramaswamy, 2008, Journal of Biological Chemistry.

Downregulation of miR‐122 in the rodent and human hepatocellular carcinomas

K. Ghoshal, J. Datta, S. Jacob, 2006, Journal of cellular biochemistry.

MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer.

K. Ghoshal, S. Jacob, T. Patel, 2007, Gastroenterology.

Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver.

M. Caligiuri, J. Mendell, K. Ghoshal, 2012, The Journal of clinical investigation.

Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis.

Thomas D. Schmittgen, C. Croce, Chang-gong Liu, 2008, Cancer research.

Down-regulation of micro-RNA-1 (miR-1) in lung cancer. Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1.

K. Ghoshal, J. Datta, S. Jacob, 2018, The Journal of Biological Chemistry.

CD44 positive and sorafenib insensitive hepatocellular carcinomas respond to the ATP-competitive mTOR inhibitor INK128

Thomas D. Schmittgen, S. Jacob, Jinmai Jiang, 2018, Oncotarget.

Transcriptomics-Based Drug Repurposing Approach Identifies Novel Drugs against Sorafenib-Resistant Hepatocellular Carcinoma

Philip R. O. Payne, Peng Hu, K. Ghoshal, 2020, Cancers.

Down-regulation of Micro-RNA-1 (miR-1) in Lung Cancer

Tasneem Motiwala, Kalpana Ghoshal, Saul Suster, 2008, Journal of Biological Chemistry.

Anti-microRNA-222 (Anti-miR-222) and -181B Suppress Growth of Tamoxifen-resistant Xenografts in Mouse by Targeting TIMP3 Protein and Modulating Mitogenic Signal*

Tyler E. Miller, B. Ramaswamy, Satavisha Roy, 2011, The Journal of Biological Chemistry.

Association of poly(A) polymerase with U1 RNA.

S. Jacob, V. S. Raju, 1988, The Journal of biological chemistry.

Downregulation of constitutive and heavy metal-induced metallothionein-I expression by nuclear factor I.

K. Ghoshal, S. Jacob, S. Majumder, 2001, Gene expression.

protein tyrosine phosphatase PTPROt in leukemia AP-1 elements and TCL1 protein regulate expression of the gene encoding

J. Byrd, C. Croce, J. Datta, 2012 .

AP-1 elements and TCL1 protein regulate expression of the gene encoding protein tyrosine phosphatase PTPROt in leukemia.

J. Byrd, C. Croce, Satavisha Roy, 2011, Blood.

Phosphatidylinositol 3-Kinase Signaling Cascade by α Inactivation of CCAAT / Enhancer Binding Protein Human Hepatocellular Carcinomas and Is Mediated through Metallothionein Expression Is Suppressed in Primary

K. Ghoshal, J. Datta, S. Jacob, 2007 .

Distinct Molecular Mechanisms Mouse Liver and Lung by Overlapping but Metallothionein Gene Expression in the Influenza Virus Infection Induces

K. Ghoshal, J. Datta, S. Jacob, 2001 .

Influenza Virus Infection Induces Metallothionein Gene Expression in the Mouse Liver and Lung by Overlapping but Distinct Molecular Mechanisms

K. Ghoshal, J. Datta, S. Jacob, 2001, Molecular and Cellular Biology.

Regulation of metallothionein gene expression.

K. Ghoshal, S. Jacob, Samson T. Jacob, 2001, Progress in nucleic acid research and molecular biology.

Analysis of promoter methylation and its role in silencing metallothionein I gene expression in tumor cells.

K. Ghoshal, S. Jacob, S. Majumder, 2002, Methods in enzymology.

Protein kinase activity of RNA polymerase I purified from a rat hepatoma: probable function of Mr 42,000 and 24,600 polypeptides.

S. Jacob, D. Stetler, K. Rose, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Enzymes of nucleic acid synthesis and modification

S. Jacob, 1983 .

Role of DNA topoisomerase I in the transcription of supercoiled rRNA gene.

S. Jacob, S. Diangelo, L. Garg, 1987, Proceedings of the National Academy of Sciences of the United States of America.

The RNA Polymerase I Promoter-activating Factor CPBF Is Functionally and Immunologically Related to the Basic Helix-Loop-Helix-Zipper DNA-binding Protein USF (*)

S. Jacob, A. Ghosh, A. Ghosh, 1995, The Journal of Biological Chemistry.

DNA-dependent RNA polymerases I and II from kidney. Effect of polyamines on the in vitro transcription of DNA and chromatin.

S. Jacob, O. Jänne, C. Bardin, 1975, Biochemistry.

Lyn kinase and ZAP70 are substrates of PTPROt in B‐cells: Lyn inactivation by PTPROt sensitizes leukemia cells to VEGF‐R inhibitor pazopanib

Satavisha Roy, J. Datta, S. Jacob, 2010, Journal of cellular biochemistry.

Antibodies against nuclear poly(A) polymerases in rheumatic autoimmune diseases

S. Jacob, M. Reichlin, D. Stetler, 2004, Journal of Clinical Immunology.

Biochemical fractionation reveals association of DNA methyltransferase (Dnmt) 3b with Dnmt1 and that of Dnmt 3a with a histone H3 methyltransferase and Hdac1

K. Ghoshal, J. Datta, S. Jacob, 2003, Journal of cellular biochemistry.

Control of gene expression by lipophilic hormones

S. Jacob, R. Reichel, Samson T. Jacob, 1993, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Heat shock inhibits pre‐rRNA processing at the primary site in vitro and alters the activity of some rRNA binding proteins

K. Ghoshal, S. Jacob, 1996, Journal of cellular biochemistry.

Heat shock selectively inhibits ribosomal RNA gene transcription and down-regulates E1BF/Ku in mouse lymphosarcoma cells.

K. Ghoshal, S. Jacob, 1996, The Biochemical journal.

Dietary fat/cholesterol-sensitive PKCβ-RB signaling: Potential role in NASH/HCC axis

K. Ghoshal, S. Jacob, K. Mehta, 2017, Oncotarget.

A new method for the preparation of liver cell suspensions.

S. Jacob, P. Bhargava, 1962, Experimental cell research.

Metallothionein Induction in Response to Restraint Stress

K. Ghoshal, S. Jacob, J. Sheridan, 1998, The Journal of Biological Chemistry.

Transcriptional induction of metallothionein-I and -II genes in the livers of Cu,Zn-superoxide dismutase knockout mice.

K. Ghoshal, S. Jacob, S. Majumder, 1999, Biochemical and biophysical research communications.

Induction of metallothionein by stress and its molecular mechanisms.

K. Ghoshal, S. Jacob, J. Sheridan, 1999, Gene expression.

Identification of T-cadherin as a Novel Target of DNA Methyltransferase 3B and Its Role in the Suppression of Nerve Growth Factor-mediated Neurite Outgrowth in PC12 Cells*

K. Ghoshal, S. Jacob, Shoumei Bai, 2006, Journal of Biological Chemistry.

Role of RNA in induction of hepatic microsomal mixed function oxidases.

S. Jacob, M. Scharf, E. S. Vessel, 1974, Proceedings of the National Academy of Sciences of the United States of America.

Suppression of Metallothionein Gene Expression in a Rat Hepatoma Because of Promoter-specific DNA Methylation*

K. Ghoshal, S. Jacob, S. Majumder, 2000, The Journal of Biological Chemistry.

Silencing of metallothionein-I gene in mouse lymphosarcoma cells by methylation

K. Ghoshal, S. Jacob, S. Majumder, 1999, Oncogene.

Hypermethylation of Metallothionein-I Promoter and Suppression of Its Induction in Cell Lines Overexpressing the Large Subunit of Ku Protein*

K. Ghoshal, S. Jacob, S. Majumder, 1999, The Journal of Biological Chemistry.

Accurate transcription of mouse metallothionein-I gene in a fractionated nuclear extract from a rat hepatoma.

S. Jacob, L. Garg, K. Maguire, 1987, The Journal of biological chemistry.

Role of de Novo DNA Methyltransferases and Methyl CpG-binding Proteins in Gene Silencing in a Rat Hepatoma*

C. Plass, K. Ghoshal, J. Datta, 2002, The Journal of Biological Chemistry.

Methylation of histone H3 and H4 by PRMT5 regulates ribosomal RNA gene transcription

Tyler E. Miller, Satavisha Roy, J. Datta, 2009, Journal of cellular biochemistry.

3 – Basic Enzymology of Transcription in Prokaryotes and Eukaryotes

S. Jacob, K. Rose, 1980 .

Lipid nanoparticles for hepatic delivery of small interfering RNA.

K. Ghoshal, S. Jacob, L. Lee, 2012, Biomaterials.

Polyriboadenylate polymerase solubilized from rat liver mitochondria.

S. Jacob, D. Schindler, 1972, Biochemical and biophysical research communications.

Mitochondrial Polyriboadenylate Polymerase: Relative Lack of Activity in Hepatomas

S. Jacob, H. Morris, D. Schindler, 1972, Science.

Sorafenib and 2-Deoxyglucose Synergistically Inhibit Proliferation of Both Sorafenib-Sensitive and -Resistant HCC Cells by Inhibiting ATP Production.

K. Ghoshal, S. Jacob, Tasneem Motiwala, 2017, Gene expression.

GENETIC REGULATION OF THE ANDROGEN RECEPTOR—A STUDY OF TESTICULAR FEMINIZATION IN THE MOUSE*

S. Jacob, O. Jänne, C. Bardin, 1976 .

Genetic regulation of the androgen receptor--a study of testicular feminization in the mouse.

S. Jacob, O. Jänne, C. Bardin, 1975, Journal of steroid biochemistry.

HORMONAL REGULATION OF RNA POLYMERASES IN LIVER AND KIDNEY

S. Jacob, O. Jänne, E. M. S. Sulkowska, 1975 .

Differential effects of cordycepin triphosphate and 9 beta-D-arabinofuranosyladenine triphosphate on tRNA and 5 S RNA synthesis in isolated nuclei.

S. Jacob, T. Leonard, 1979, Biochimica et biophysica acta.

Selective inhibition of RNA polyadenylation by Ara-ATP in vitro: a possible mechanism for antiviral action of Ara-A.

S. Jacob, K. Rose, 1978, Biochemical and biophysical research communications.

Enhancer 1 binding factor, a Ku-related protein, is a positive regulator of RNA polymerase I transcription initiation.

S. Jacob, B. Prabhakar, A. Ghosh, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Control of RNA polymerase I‐directed transcription: Recent trends

S. Jacob, Asish Ghosh, A. Ghosh, 1999, Journal of cellular biochemistry.

Turnover of 45 S RNA of regenerating liver and Walker tumor.

S. Jacob, W. J. Steele, H. Busch, 1967, Cancer research.

Polyadenylate polymerases from normal and cancer cells and their potential role in messenger RNA processing: a review.

S. Jacob, M. Terns, K. Maguire, 1989, Cancer research.

Role of poly(A) polymerase in the cleavage and polyadenylation of mRNA precursor

S. Jacob, M. Terns, 1989, Molecular and cellular biology.

Identification of a Novel Cyclic AMP-response Element (CRE-II) and the Role of CREB-1 in the cAMP-induced Expression of the Survival Motor Neuron (SMN) Gene*

K. Ghoshal, S. Jacob, S. Majumder, 2004, Journal of Biological Chemistry.

Purification and Characterization of a Rat Liver Protein That Recognizes CCAAT-Homologous Sequences of the Metallothionein Promoter andtrans-Activates This Promoter

S. Jacob, L. P. Aniskovitch, 1997 .

Anti-poly(A) polymerase antibodies in the sera of tumor-bearing rats can inhibit specific cleavage and polyadenylation reactions.

S. Jacob, V. S. Raju, 1991, Carcinogenesis.

The dual role of helix – loop – helix-zipper protein USF in ribosomal RNA gene transcription in vivo

S. Jacob, A. Ghosh, P. Datta, 1997, Oncogene.

Rat ribosomal RNA gene can utilize primate RNA polymerase I transcription machinery: lack of absolute species specificity in rDNA transcription.

S. Jacob, A. Ghosh, H. Niu, 1996, Biochemical and biophysical research communications.

Regulation of ribosomal gene transcription.

S. Jacob, 1995, The Biochemical journal.

E1BF/Ku interacts physically and functionally with the core promoter binding factor CPBF and promotes the basal transcription of rat and human ribosomal RNA genes.

S. Jacob, J. Zhang, H. Niu, 1995, Gene expression.

Characterization of a protein that interacts with the rat ribosomal gene promoter and modulates RNA polymerase I transcription.

S. Jacob, Z. Liu, 1994, The Journal of biological chemistry.

Characterization of the factor E1BF from a rat hepatoma that modulates ribosomal RNA gene transcription and its relationship to the human Ku autoantigen.

S. Jacob, C. Hoff, 1993, Biochemical and biophysical research communications.

Purification and characterization of a novel factor which stimulates rat ribosomal gene transcription in vitro by interacting with enhancer and core promoter elements

S. Jacob, J. Zhang, 1990, Molecular and cellular biology.

Glucocorticoid-induced stimulation of ribosomal gene transcription in rat hepatoma cells is mediated by modification of RNA polymerase I or an associated factor.

S. Jacob, M. Webb, J. F. Mealey-Cavender, 1989, Molecular endocrinology.

Cellular DNA replication is independent of the synthesis or accumulation of ribosomal RNA.

S. Jacob, N. Galanti, W. Mercer, 1984, Experimental cell research.

Activation of the Connective Tissue Growth Factor (CTGF)-Transforming Growth Factor β 1 (TGF-β 1) Axis in Hepatitis C Virus-Expressing Hepatocytes

K. Ghoshal, S. Jacob, A. Balasubramanian, 2012, PloS one.

Specific inhibition of pre-ribosomal RNA processing in extracts from the lymphosarcoma cells treated with 5-fluorouracil.

K. Ghoshal, S. Jacob, 1994, Cancer research.

Phosphorylation of purified glucocorticoid receptor from rat liver by an endogenous protein kinase.

S. Jacob, R. Kurl, 1984, Biochemical and biophysical research communications.

Activation of purified hepatoma RNA polymerase I by homologous protein kinase NII.

S. Jacob, B. Duceman, K. Rose, 1981, The Journal of biological chemistry.

Expression of purified mitochondrial poly(A)polymerase of hepatomas by an endogenous primer from liver..

S. Jacob, H. Morris, K. Rose, 1974, Biochimica et biophysica acta.

Different responses of soluble whole nuclear RNA polymerase and soluble nucleolar RNA polymerase to divalent cations and to inhibition by alpha-amanitin.

S. Jacob, H. Munro, E. M. Sajdel, 1970, Biochemical and biophysical research communications.

Effect of medroxyprogesterone acetate and testosterone on solubilized RNA polymerases and chromatin template activity in kidney from normal and androgen-insensitive (Tfm/Y) mice.

S. Jacob, C. Bardin, Y. C. Lin, 1978, Biochemistry.

Two functional states of poly(adenylic acid) polymerase in isolated nuclei.

S. Jacob, K. Rose, F. J. Roe, 1977, Biochimica et biophysica acta.

Specific inhibition of chromatin-associated poly(A) synthesis in vitro by cordycepin 5′-triphosphate

S. Jacob, K. Rose, L. E. Bell, 1977, Nature.

Selective inhibition of initial polyadenylation in isolated nuclei by low levels of cordycepin 5"-triphosphate.

S. Jacob, K. Rose, L. E. Bell, 1977, Biochimica et biophysica acta.

Evidence for the nuclear origin of RNA polymerases identified in the cytosol: release of enzymes from the nuclei isolated in isotonic sucrose.

S. Jacob, Y. C. Lin, K. Rose, 1976, Biochemical and biophysical research communications.

Nuclear poly(A) polymerase from rat liver and a hepatoma. Comparison of properties, molecular weights and amino acid compositions.

S. Jacob, K. Rose, 1976, European journal of biochemistry.

RNA polymerases from a rat hepatoma. Partial purification and comparison of properties with corresponding liver enzymes.

S. Jacob, H. Morris, K. Rose, 1976, Biochimica et biophysica acta.

Early androgen action in kidney of normal and androgen-insensitive (tfm/y) mice. Changes in RNA polymerase and chromatin template activities.

S. Jacob, O. Jänne, C. Bardin, 1976, Biochimica et biophysica acta.

Nuclear RNA, Histones and Differentiation

T. Nakamura, S. Jacob, S. J. Smith, 1966 .

Regulation of nucleolar RNA metabolism by hydrocortisone.

S. Jacob, H. Munro, E. M. Sajdel, 2005, European journal of biochemistry.

Presence of two RNA polymerase activities in liver nucleoli.

S. Jacob, H. Munro, E. M. Sajdel, 1968, Biochimica et biophysica acta.

Mitochondrial poly(A) polymerase from a poorly differentiated hepatoma: purification and characteristics.

S. Jacob, H. Morris, K. Rose, 1975, Biochemistry.

Production of monoclonal antibodies against RNA polymerase I from nonimmunized autoimmune MRL/lpr mice and their use in rDNA transcription analysis.

C. Balaban, S. Jacob, A. Barsoum, 1987, The Journal of biological chemistry.

The Role of Receptors in the Anabolic Action of Androgens

S. Jacob, C. Bardin, N. Mills, 1978 .

Cell-free synthesis of tumor-type poly(A) polymerase.

S. Jacob, K. Maguire, 1986, Biochemistry.

Suppression of metallothionein-I/II expression and its probable molecular mechanisms.

K. Ghoshal, S. Jacob, S. Majumder, 2002, Environmental health perspectives.

Methylation and Silencing of Protein Tyrosine Phosphatase Receptor Type O in Chronic Lymphocytic Leukemia

M. Grever, J. Byrd, D. Neuberg, 2007, Clinical Cancer Research.

Methylation and Silencingof Protein Tyrosine Phosphatase Receptor Type O in Chronic Lymphocytic Leukemia

M. Grever, J. Byrd, D. Neuberg, 2007 .

Chromium(VI) Down-regulates Heavy Metal-induced Metallothionein Gene Transcription by Modifying Transactivation Potential of the Key Transcription Factor, Metal-responsive Transcription Factor 1*

K. Ghoshal, J. Datta, S. Jacob, 2003, Journal of Biological Chemistry.

A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation.

K. Ghoshal, J. Datta, S. Jacob, 2009, Cancer research.

Indole-3-carbinol inhibits tumorigenicity of hepatocellular carcinoma cells via suppression of microRNA-21 and upregulation of phosphatase and tensin homolog.

L. J. Lee, K. Ghoshal, S. Jacob, 2015, Biochimica et biophysica acta.

Altered characteristics of mammalian RNA polymerase following solubilization from nuclei.

S. Jacob, H. Munro, E. M. Sajdel, 1968, Biochemical and biophysical research communications.

Mammalian RNA polymerases.

S. Jacob, Samson T. Jacob, 1973, Progress in nucleic acid research and molecular biology.

An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug.

K. Ghoshal, S. Jacob, 1997, Biochemical pharmacology.

Antibodies to distinct polypeptides of RNA polymerase I in sera from patients with rheumatic autoimmune disease.

S. Jacob, D. Stetler, K. Rose, 1982, Proceedings of the National Academy of Sciences of the United States of America.

A heparin-sensitive nuclear protein kinase. Purification, properties, and increased activity in rat hepatoma relative to liver.

S. Jacob, K. Rose, L. E. Bell, 1981, The Journal of biological chemistry.

Phosphorylation of nuclear poly(A) polymerase. Comparison of liver and hepatoma enzymes.

S. Jacob, K. Rose, 1979, The Journal of biological chemistry.

Inhibition of RNA polymerase I-directed transcription by novobiocin. Potential use of novobiocin as a general inhibitor of eukaryotic transcription initiation.

S. Jacob, M. Webb, 1988, The Journal of biological chemistry.

Novobiocin inhibits initiation of RNA polymerase II-directed transcription of the mouse metallothionein-I gene independent of its effect on DNA topoisomerase II.

S. Jacob, K. Maguire, M. Webb, 1987, Nucleic acids research.

Anti-RNA polymerase I antibodies in sera of MRL lpr/lpr and MRL +/+ autoimmune mice. Correlation of antibody production with delayed onset of lupus-like disease in MRL +/+ mice

S. Jacob, D. Stetler, D. Sipes, 1985, The Journal of experimental medicine.

Comparison of cytosolic and nuclear poly(A) polymerases from rat liver and a hepatoma: structural and immunological properties and response to NI-type protein kinases.

S. Jacob, D. Stetler, 1985, Biochemistry.

Phosphorylation of RNA polymerases: specific association of protein kinase NII with RNA polymerase I.

S. Jacob, D. Stetler, K. Rose, 1983, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

METABOLISM OF TISSUE CELLS IN SUSPENSION. SYNTHESIS OF RIBONUCLEIC ACID BY LEIVER CELLS IN SUSPENSION.

S. Jacob, P. Bhargava, 1965, The Biochemical journal.

Alterations in DNA-dependent RNA polymerase I and II from rat liver by thioacetamide: preferential increase in the level of chromatin-associated nucleolar RNA polymerase IB.

S. Jacob, T. Leonard, 1977, Biochemistry.

Poly(adenylic acid) synthesis in isolated rat liver mitochondria.

S. Jacob, K. Rose, 1976, Biochemistry.

Poly(adenylic acid) polymerase: Loss of enzyme from rat liver nuclei isolated under isotonic conditions

S. Jacob, K. Rose, Yen-Chiu Lin, 1976, FEBS letters.

5-Aza-Deoxycytidine Induces Selective Degradation of DNA Methyltransferase 1 by a Proteasomal Pathway That Requires the KEN Box, Bromo-Adjacent Homology Domain, and Nuclear Localization Signal

K. Ghoshal, J. Datta, S. Jacob, 2005, Molecular and Cellular Biology.

An enhancer element in the far upstream spacer region of rat ribosomal RNA gene.

S. Jacob, A. Dixit, W. Chao, 1987, The Journal of biological chemistry.

Accurate initiation of rat ribosomal RNA gene transcription using a fractionated nuclear extract from normal liver and a hepatoma.

S. Jacob, R. Kurl, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Soluble RNA Polymerases of Rat Liver Nuclei: Properties, Template Specificity, and Amanitin Responses in vitro and in vivo

S. Jacob, H. Munro, W. Muecke, 1970 .

Biological Sciences: Specific Action of α-Amanitin on Mammalian RNA Polymerase Protein

S. Jacob, H. Munro, E. M. Sajdel, 1970, Nature.

Poly(A) polymerase and poly(A)-specific mRNA binding protein are antigenically related

S. Jacob, Ajit Kumar, K. Rose, 1979, Nature.

Activation of the metallothionein-I gene promoter in response to cadmium and USF in vitro.

S. Jacob, P. Datta, 1997, Biochemical and biophysical research communications.

Characterization of the 130-bp repeat enhancer element of the rat ribosomal gene: functional interaction with transcription factor E1BF.

S. Jacob, A. Ghosh, C. Hoff, 1993, Gene.

A cis-acting sequence within the rat ribosomal DNA enhancer region can modulate RNA polymerase II-directed transcription of the metallothionein I gene in vitro.

S. Jacob, A. Dixit, L. Garg, 1989, DNA.

Role of Poly(ADP-Ribose) Polymerase in Ribosomal RNA Gene Transcription

S. Jacob, J. Mealey, R. Kurl, 1989 .

Multiple functional enhancer motifs of rat ribosomal gene

S. Jacob, L. Garg, C. Book, 2004, Molecular and Cellular Biochemistry.

Regulation of ribosomal RNA gene transcription during retinoic acid-induced differentiation of mouse teratocarcinoma cells.

S. Jacob, P. Datta, S. Budhiraja, 1997, Experimental cell research.

Effects of repetitive and non-repetitive rat rDNA enhancer elements on in vivo transcription by RNA polymerases I and II.

S. Jacob, A. Ghosh, M. Kermekchiev, 1994, Gene.

Specific action of alpha-amanitin on mammalian RNA polymerase protein.

S. Jacob, H. Munro, E. M. Sajdel, 1970, Nature.

Mechanism of inhibition of RNA polymerase II and poly(adenylic acid) polymerase by the O-n-octyloxime of 3-formylrifamycin SV.

S. Jacob, K. Rose, P. Ruch, 1975, Biochemistry.

Template activity of nuclear RNA fractions of the Walker tumor.

S. Jacob, H. Busch, 1967, Biochimica et biophysica acta.

TGFβ mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3

K. Ghoshal, S. Jacob, S. Majumder, 2009, Oncogene.

Role of microRNA‐155 at early stages of hepatocarcinogenesis induced by choline‐deficient and amino acid–defined diet in C57BL/6 mice

Bo Wang, Stefano Volinia, Tushar Patel, 2009, Hepatology.

Evidence for extranucleolar control of RNA synthesis in the nucleolus.

S. Jacob, H. Munro, W. Muecke, 1970, Biochemical and biophysical research communications.

Low levels of miR‐92b/96 induce PRMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma

Sharmistha Pal, M. Grever, J. Byrd, 2007, The EMBO journal.

Cationic lipid nanoparticles for therapeutic delivery of siRNA and miRNA to murine liver tumor.

L. J. Lee, K. Ghoshal, S. Jacob, 2013, Nanomedicine : nanotechnology, biology, and medicine.

Stat3‐mediated activation of microRNA‐23a suppresses gluconeogenesis in hepatocellular carcinoma by down‐regulating Glucose‐6‐phosphatase and peroxisome proliferator‐activated receptor gamma, coactivator 1 alpha

K. Ghoshal, S. Jacob, W. Frankel, 2012, Hepatology.

HOXB13, a Target of DNMT3B, Is Methylated at an Upstream CpG Island, and Functions as a Tumor Suppressor in Primary Colorectal Tumors

C. Plass, K. Ghoshal, J. Datta, 2010, PloS one.

DNA Methyltransferase 3b Regulates Nerve Growth Factor-Induced Differentiation of PC12 Cells by Recruiting Histone Deacetylase 2

K. Ghoshal, J. Datta, S. Jacob, 2005, Molecular and Cellular Biology.

PTPROt Inactivates the Oncogenic Fusion Protein BCR/ABL and Suppresses Transformation of K562 Cells*

K. Ghoshal, Satavisha Roy, J. Datta, 2009, Journal of Biological Chemistry.

Role of protein tyrosine phosphatases in cancer.

S. Jacob, Tasneem Motiwala, 2006, Progress in nucleic acid research and molecular biology.

Reciprocal regulation of microRNA‐122 and c‐Myc in hepatocellular cancer: Role of E2F1 and transcription factor dimerization partner 2

K. Ghoshal, S. Jacob, R. Ganju, 2014, Hepatology.

Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer.

C. Morrison, K. Ghoshal, S. Jacob, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Metallothionein expression is suppressed in primary human hepatocellular carcinomas and is mediated through inactivation of CCAAT/enhancer binding protein alpha by phosphatidylinositol 3-kinase signaling cascade.

K. Ghoshal, J. Datta, S. Jacob, 2007, Cancer research.

Role of B Cell Lymphoma 2 in the Regulation of Liver Fibrosis in miR-122 Knockout Mice

K. Ghoshal, S. Jacob, Juan M. Barajas, 2020, Biology.

Role of Human Ribosomal RNA (rRNA) Promoter Methylation and of Methyl-CpG-binding Protein MBD2 in the Suppression of rRNA Gene Expression*

K. Ghoshal, J. Datta, S. Jacob, 2004, Journal of Biological Chemistry.

Epigenetic regulation of metallothionein‐i gene expression: Differential regulation of methylated and unmethylated promoters by DNA methyltransferases and methyl CpG binding proteins

K. Ghoshal, J. Datta, S. Jacob, 2006, Journal of cellular biochemistry.

Suppression of the protein tyrosine phosphatase receptor type O gene (PTPRO) by methylation in hepatocellular carcinomas

Yue-zhong Wu, C. Plass, K. Ghoshal, 2003, Oncogene.

Mechanism of early effect of hydrocortisone on the transcriptional process: stimulation of the activities of purified rat liver nucleolar RNA polymerases.

S. Jacob, E. M. Sajdel, 1971, Biochemical and biophysical research communications.

Mammalian RNA polymerases and their selective inhibition by amanitin.

S. Jacob, H. Munro, E. M. Sajdel, 1970, Advances in enzyme regulation.

Loss of metallothionein predisposes mice to diethylnitrosamine-induced hepatocarcinogenesis by activating NF-kappaB target genes.

Tsonwin Hai, K. Ghoshal, Satavisha Roy, 2010, Cancer research.

Genetic validation of the protein arginine methyltransferase PRMT5 as a candidate therapeutic target in glioblastoma.

Guido Marcucci, Xin Wu, Fengting Yan, 2014, Cancer research.

Simultaneous metabolic labeling of cells with multiple amino acids: Localization and dynamics of histone acetylation and methylation

Michael A. Freitas, K. Ghoshal, S. Jacob, 2007, Proteomics. Clinical applications.

Erratum: Down-regulation of micro-RNA-1 (miR-1) in lung cancer. Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1 (Journal of Biological Chemistry (2018) 293 (33394–33405) DOI: 10.1074/jbc.M804788200)

Gerard J. Nuovo, Tasneem Motiwala, Kalpana Ghoshal, 2008 .

Epigenetic regulation of protein tyrosine phosphatases: potential molecular targets for cancer therapy

S. Jacob, Tasneem Motiwala, 2005, Cancer Gene Therapy.

Reduced Susceptibility of DNA Methyltransferase 1 Hypomorphic (Dnmt1N/+) Mice to Hepatic Steatosis upon Feeding Liquid Alcohol Diet

K. Ghoshal, J. Datta, S. Jacob, 2012, PloS one.

Phosphorylation of nuclear poly(adenylic acid) polymerase by protein kinase: mechanism of enhanced poly(adenylic acid) synthesis.

S. Jacob, K. Rose, 1980, Biochemistry.

Estrogen-mediated suppression of the gene encoding protein tyrosine phosphatase PTPRO in human breast cancer: mechanism and role in tamoxifen sensitivity.

K. Ghoshal, B. Ramaswamy, Satavisha Roy, 2009, Molecular endocrinology.

, Domain , and Nuclear Localization Signal KEN Box , Bromo-Adjacent Homology a Proteasomal Pathway That Requires the Degradation of DNA Methyltransferase 1 by 5-Aza-Deoxycytidine Induces Selective

K. Ghoshal, J. Datta, S. Jacob, 2005 .

Transcription of eukaryotic ribosomal RNA gene

S. Jacob, 1986, Molecular and Cellular Biochemistry.

Novel Insights into the Molecular Mechanism of Action of DNA Hypomethylating Agents: Role of Protein Kinase C δ in Decitabine-Induced Degradation of DNA Methyltransferase 1.

K. Ghoshal, J. Datta, S. Jacob, 2012, Genes & cancer.

Role of DNA Methyltransferases in Regulation of Human Ribosomal RNA Gene Transcription*

K. Ghoshal, J. Datta, S. Jacob, 2006, Journal of Biological Chemistry.

A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats.

K. Ghoshal, J. Datta, S. Jacob, 2006, The Journal of nutrition.

Physical and functional interaction of DNA methyltransferase 3A with Mbd3 and Brg1 in mouse lymphosarcoma cells.

K. Ghoshal, S. Jacob, S. Majumder, 2005, Cancer research.

Inhibitors of Histone Deacetylase and DNA Methyltransferase Synergistically Activate the Methylated Metallothionein I Promoter by Activating the Transcription Factor MTF-1 and Forming an Open Chromatin Structure

K. Ghoshal, J. Datta, S. Jacob, 2002, Molecular and Cellular Biology.

Mitochondrial Transcription Factor A and Its Downstream Targets Are Up-regulated in a Rat Hepatoma*

K. Ghoshal, S. Jacob, S. Majumder, 2002, The Journal of Biological Chemistry.

Overexpression of the large subunit of the protein Ku suppresses metallothionein-I induction by heavy metals.

K. Ghoshal, S. Jacob, Z. Li, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Functional role of zinc in poly(A) synthesis catalyzed by nuclear poly(A) polymerase.

S. Jacob, I. Crawford, K. Rose, 1978, European journal of biochemistry.

Ibrutinib Potentiates Antihepatocarcinogenic Efficacy of Sorafenib by Targeting EGFR in Tumor Cells and BTK in Immune Cells in the Stroma

K. Ghoshal, S. Jacob, Lianbo Yu, 2019, Molecular Cancer Therapeutics.

Low levels of miR-92 b / 96 induce PRMT 5 translation and H 3 R 8 / H 4 R 3 methylation in mantle cell lymphoma

M. Grever, J. Byrd, S. Jacob, 2013 .

Further studies on post-transcriptional stabilization of ribosomal precursor ribonucleic acid by phenobarbital.

S. Jacob, S. J. Smith, B. Duceman, 1974, Molecular pharmacology.

Turnover of the poly(A) moiety of mRNA in wheat-germ extract.

S. Jacob, A. Pihl, A. K. Abraham, 1980, European journal of biochemistry.

Blocking the CCL2–CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model

M. Caligiuri, K. Ghoshal, S. Jacob, 2016, Molecular Cancer Therapeutics.

Transcriptionally active RNA polymerases from Morris hepatomas and rat liver. Elucidation of the mechanism for the preferential increase in the tumour RNA polymerase I.

S. Jacob, B. Duceman, 1980, The Biochemical journal.

Poly(A) synthesis by RNA polymerase II from rat liver.

S. Jacob, K. Rose, 1974, Biochemical and biophysical research communications.

PTPROt-mediated regulation of p53/Foxm1 suppresses leukemic phenotype in a CLL mouse model

S. Jacob, N. Zanesi, X. Mo, 2014, Leukemia.

Methylation of the PTPRO gene in human hepatocellular carcinoma and identification of VCP as its substrate

Michael A. Freitas, C. Plass, K. Ghoshal, 2013, Journal of cellular biochemistry.

Treatment of PC12 Cells with Nerve Growth Factor Induces Proteasomal Degradation of T-cadherin That Requires Tyrosine Phosphorylation of Its Cadherin Domain*

K. Ghoshal, J. Datta, S. Jacob, 2007, Journal of Biological Chemistry.

Enhanced hepatic delivery of siRNA and microRNA using oleic acid based lipid nanoparticle formulations.

L. J. Lee, K. Ghoshal, S. Jacob, 2013, Journal of controlled release : official journal of the Controlled Release Society.

Structure-activity relationships for 4-anilinoquinoline derivatives as inhibitors of the DNA methyltransferase enzyme DNMT1.

J. Datta, S. Jacob, S. Gamage, 2013, Bioorganic & medicinal chemistry.

Peptide mass mapping of acetylated isoforms of histone H4 from mouse lymphosarcoma cells treated with histone deacetylase (HDACs) inhibitors

Michael A. Freitas, K. Ghoshal, S. Jacob, 2005, Journal of the American Society for Mass Spectrometry.

Hydrolysis of poly (A) to adenine nucleotides by purified poly (A) polymerase.

S. Jacob, A. K. Abraham, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Ara-ATP impairs 3'-end processing of pre-mRNAs by inhibiting both cleavage and polyadenylation.

K. Ghoshal, S. Jacob, 1991, Nucleic acids research.

Association of newly synthesized poly(A) polymerase with four distinct polypeptides.

S. Jacob, I. Georgoff, H. Isom, 1988, The Journal of biological chemistry.

Phosphorylation and immunology of poly(A) polymerase.

S. Jacob, K. Rose, 1984, Advances in enzyme regulation.

Autoantibodies against RNA polymerase I in scleroderma and Sjögren's syndrome sera.

S. Jacob, M. Reichlin, D. Stetler, 1987, Biochemical and biophysical research communications.

Composition of nucleoli isolated from mammalian cells.

S. Jacob, K. Higashi, M. Muramatsu, 1966, National Cancer Institute monograph.

Phosphorylation of RNA polymerase I augments its interaction with autoantibodies of systemic lupus erythematosus patients.

S. Jacob, D. Stetler, 1984, The Journal of biological chemistry.

Spermine-mediated phosphorylation of RNA polymerase I and its effect on transcription.

S. Jacob, B. Duceman, K. Rose, 1981, Medical biology.

Anti-protein kinase NII antibodies in rheumatic autoimmune diseases.

S. Jacob, D. Stetler, K. Rose, 1984, The Journal of biological chemistry.

Regulation of glucose metabolism in hepatocarcinogenesis by microRNAs.

S. Jacob, Tasneem Motiwala, Ryan Reyes, 2014, Gene expression.

Immunization of rabbits with purified RNA polymerase I induces a distinct population of antibodies against nucleic acids as well as anti-RNA polymerase I antibodies, both characteristic of systemic lupus erythematosus.

S. Jacob, D. Stetler, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Physicochemical and biological properties of androgen receptors.

S. Jacob, O. Jänne, C. Bardin, 1975, Current topics in molecular endocrinology.

Three distinct forms of DNA-dependent RNA polymerase III from kidney.

S. Jacob, B. Duceman, 1977, Biochemical and biophysical research communications.

Stimulation of RNA polymerases I, II and III from rat liver by spermine, and specific inhibition of RNA polymerase I by higher spermine concentrations.

S. Jacob, K. Rose, 1976, Biochimica et biophysica acta.

Inhibition of the polyadenylation reaction in vitro by polyamines.

S. Jacob, K. Rose, 1976, Archives of biochemistry and biophysics.

Reprograming of Glucose Metabolism by Zerumbone Suppresses Hepatocarcinogenesis

R. Brüschweiler, K. Ghoshal, S. Jacob, 2017, Molecular Cancer Research.

The role of miR-122 in the dysregulation of glucose-6-phosphate dehydrogenase (G6PD) expression in hepatocellular cancer

K. Ghoshal, S. Jacob, Juan M. Barajas, 2018, Scientific Reports.

Absence of inactivation or phosphorylation of ornithine decarboxylase by nuclear protein kinase NII and of immunological cross-reactivity between RNA polymerase I and ornithine decarboxylase.

S. Jacob, A. Pegg, J. Seely, 1984, Biochemical and Biophysical Research Communications - BBRC.

Enhancer 1 binding factor (E1BF), a Ku-related protein, is a growth-regulated RNA polymerase I transcription factor: association of a repressor activity with purified E1BF from serum-deprived cells.

S. Jacob, H. Niu, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Role of cancer stem cells in hepatocarcinogenesis

S. Jacob, Bo Wang, 2011, Genome Medicine.

A purified fraction containing RNA polymerase I that can accurately transcribe rat ribosomal RNA gene.

S. Jacob, L. Rothblum, R. Kurl, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Polyadenylation of SV40 late pre-mRNA is dependent on phosphorylation of an essential component associated with the 3' end processing machinery.

S. Jacob, K. Chrislip, J. A. Hengst-Zhang, 1991, Gene expression.

DNA-dependent RNA polymerases from Morris hepatomas 3924A and 7800 and from liver treated with thioacetamide.

S. Jacob, B. Duceman, K. Rose, 1977, Advances in experimental medicine and biology.

MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27(kip1).

Tyler E. Miller, K. Ghoshal, B. Ramaswamy, 2009 .

The role of miR-122 in the dysregulation of glucose-6-phosphate dehydrogenase (G6PD) expression in hepatocellular cancer

K. Ghoshal, S. Jacob, Juan M. Barajas, 2018, Scientific Reports.

Purification and characterization of a nuclear protein kinase from rat liver and a hepatoma that is capable of activating poly(A) polymerase.

S. Jacob, D. Stetler, B. Seidel, 1984, The Journal of biological chemistry.

Identification of T-cadherin as a novel target of DNA methyltransferase 3B and its role in the suppression of nerve growth factor-mediated neurite outgrowth in PC12 cells.

K. Ghoshal, S. Jacob, Shoumei Bai, 2018, Journal of Biological Chemistry.