I. Pogribny

I. Pogribny, V. Tryndyak, M. Churchwell, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Reduction of p53 gene expression in human primary hepatocellular carcinoma is associated with promoter region methylation without coding region mutation.

I. Pogribny, S. J. James, S. James, 2002, Cancer letters.

Environmental toxicants, epigenetics, and cancer.

Ivan Rusyn, I. Rusyn, I. Pogribny, 2013, Advances in experimental medicine and biology.

Sex-specific differences in genotoxic and epigenetic effects of 1,3-butadiene among mouse tissues

I. Rusyn, I. Pogribny, N. Tretyakova, 2018, Archives of Toxicology.

Genetic and epigenetic changes in rat preneoplastic liver tissue induced by 2-acetylaminofluorene.

T. Bagnyukova, I. Pogribny, V. Tryndyak, 2008, Carcinogenesis.

Epigenetic Effects of Bisphenol A (BPA): A Literature Review in the Context of Human Dietary Exposure

I. Pogribny, L. Camacho, 2019, Handbook of Nutrition, Diet, and Epigenetics.

Epigenetic Effects of Bisphenol A (BPA): A Literature Review in the Context of Human Dietary Exposure

I. Pogribny, L. Camacho, 2019, Handbook of Nutrition, Diet, and Epigenetics.

Low dose assessment of the carcinogenicity of furan in male F344/N Nctr rats in a 2-year gavage study.

I. Pogribny, B. Thorn, N. Walker, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

The role of epigenomic alterations in furan-induced hepatobiliary pathologies.

I. Pogribny, F. Beland, A. de Conti, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Identification of chromatin‐accessible domains in non‐alcoholic steatohepatitis‐derived hepatocellular carcinoma

W. Xiao, I. Pogribny, M. L. Dechassa, 2018, Molecular carcinogenesis.

Effect of methapyrilene hydrochloride on hepatic intracellular iron metabolism in vivo and in vitro.

Thilak K. Mudalige, Tao Chen, I. Pogribny, 2017, Toxicology letters.

Epigenetic aberrations of gene expression in a rat model of hepatocellular carcinoma

I. Pogribny, T. Huan, B. Stefańska, 2022, Epigenetics.

Effects of oral exposure to bisphenol A on gene expression and global genomic DNA methylation in the prostate, female mammary gland, and uterus of NCTR Sprague-Dawley rats.

J. Fuscoe, T. Han, I. Koturbash, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Folate / methyl-deficient Rats Associated with Hypomethylation in Livers of Gene Are p 53 Breaks in Genomic DNA and within the Updated Version

L. Poirier, I. Pogribny, A. Basnakian, 2006 .

Epigenetics of Dietary Methyl-Group Donor Deficiency and Liver Cancer

I. Pogribny, A. Conti, 2019, Handbook of Nutrition, Diet, and Epigenetics.

Studies of methionine cycle intermediates (SAM, SAH), DNA methylation and the impact of folate deficiency on tumor numbers in Min mice.

I. Pogribny, R. Rozen, S. J. James, 2002, Carcinogenesis.

Butyrate-containing structured lipids act on HDAC4, HDAC6, DNA damage and telomerase activity during promotion of experimental hepatocarcinogenesis.

I. Pogribny, C. Herz, E. Purgatto, 2021, Carcinogenesis.

S-adenosylhomocysteine hydrolase deficiency in a human: A genetic disorder of methionine metabolism

I. Pogribny, S. J. James, S. Zeisel, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Role of DNA hypomethylation in the development of the resistance to doxorubicin in human MCF-7 breast adenocarcinoma cells.

I. Pogribny, O. Yurchenko, V. Tryndyak, 2006, Cancer letters.

Analysis of mutations in the K-ras and p53 genes of lung tumors and in the hprt gene of 6-thioguanine-resistant T-lymphocytes from rats treated with 1,6-dinitropyrene.

R. Mittelstaedt, I. Pogribny, M. Manjanatha, 1997, Mutation research.

Assessment of the effects of organic vs. inorganic arsenic and mercury in Caenorhabditis elegans

I. Pogribny, P. Hunt, J. Camacho, 2022, Current research in toxicology.

The DEN and CCl4‐Induced Mouse Model of Fibrosis and Inflammation‐Associated Hepatocellular Carcinoma

I. Rusyn, I. Pogribny, T. Uehara, 2021, Current protocols.

Characterization of copy number alterations in a mouse model of fibrosis‐associated hepatocellular carcinoma reveals concordance with human disease

I. Rusyn, I. Pogribny, T. Uehara, 2016, Cancer medicine.

Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation

I. Pogribny, S. Ross, O. Orisakwe, 2017, Molecular Cancer Research.

Global Leukocyte DNA Methylation is Similar in African American and Caucasian Women Under Conditions of Controlled Folate Intake

I. Pogribny, M. Caudill, Steven S. Smith, 2007, Epigenetics.

The chemopreventive activity of the butyric acid prodrug tributyrin in experimental rat hepatocarcinogenesis is associated with p53 acetylation and activation of the p53 apoptotic signaling pathway.

I. Koturbash, I. Pogribny, V. Tryndyak, 2013, Carcinogenesis.

Interstrain differences in liver injury and one‐carbon metabolism in alcohol‐fed mice

I. Rusyn, I. Pogribny, O. Kosyk, 2012, Hepatology.

Histopathological and molecular signatures of a mouse model of acute-on-chronic alcoholic liver injury demonstrate concordance with human alcoholic hepatitis.

I. Rusyn, I. Pogribny, R. Bataller, 2018, Toxicological sciences : an official journal of the Society of Toxicology.

Nonalcoholic Fatty Liver Disease Is a Susceptibility Factor for Perchloroethylene-Induced Liver Effects in Mice.

I. Rusyn, I. Pogribny, D. Threadgill, 2017, Toxicological sciences : an official journal of the Society of Toxicology.

Characterization of the variability in the extent of nonalcoholic fatty liver induced by a high‐fat diet in the genetically diverse Collaborative Cross mouse model

I. Rusyn, I. Pogribny, S. Ross, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Cellular and Molecular Effects of Prolonged Low-Level Sodium Arsenite Exposure on Human Hepatic HepaRG Cells

Thilak K. Mudalige, I. Pogribny, O. Orisakwe, 2018, Toxicological sciences : an official journal of the Society of Toxicology.

MicroRNA deregulation in nonalcoholic steatohepatitis-associated liver carcinogenesis

I. Rusyn, I. Pogribny, V. Tryndyak, 2017, Oncotarget.

Butyrate-containing structured lipids inhibit RAC1 and epithelial-to-mesenchymal transition markers: A chemopreventive mechanism against hepatocarcinogenesis.

I. Rusyn, I. Pogribny, V. Tryndyak, 2020, The Journal of nutritional biochemistry.

Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet.

I. Rusyn, T. Bagnyukova, I. Pogribny, 2009, Journal of hepatology.

MicroRNA hsa-miR-29a-3p modulates CYP2C19 in human liver cells.

N. Mei, B. Ning, I. Pogribny, 2015, Biochemical pharmacology.

S-Adenosylhomocysteine hydrolase deficiency: A second patient, the younger brother of the index patient, and outcomes during therapy

I. Pogribny, S. Zeisel, M. Radoš, 2005, Journal of Inherited Metabolic Disease.

MicroRNA changes, activation of progenitor cells and severity of liver injury in mice induced by choline and folate deficiency.

I. Pogribny, V. Tryndyak, L. Muskhelishvili, 2016, The Journal of nutritional biochemistry.

Differential sensitivity to loss of cytosine methyl groups within the hepatic p53 gene of folate/methyl deficient rats.

L. Poirier, I. Pogribny, S. J. James, 1995, Carcinogenesis.

Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology.

I. Pogribny, M. Pogribna, S. J. James, 2002, The Journal of nutrition.

Epigenetic effects of the continuous exposure to peroxisome proliferator WY-14,643 in mouse liver are dependent upon peroxisome proliferator activated receptor alpha.

I. Rusyn, I. Pogribny, C. Woods, 2007, Mutation research.

Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice.

I. Pogribny, R. Rozen, E. Li, 2003, Carcinogenesis.

Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene.

I. Pogribny, J. Mason, A. Basnakian, 1997, The American journal of clinical nutrition.

Oxidative stress and antioxidant defenses in goldfish liver in response to short‐term exposure to arsenite

T. Bagnyukova, I. Pogribny, V. Lushchak, 2007, Environmental and molecular mutagenesis.

Antiproliferative and proapoptotic effects of a pyrrole containing arylthioindole in human Jurkat leukemia cell line and multidrug-resistant Jurkat/A4 cells

I. Pogribny, R. Silvestri, V. Tryndyak, 2015, Cancer biology & therapy.

Status of hepatic DNA methylome predetermines and modulates the severity of non-alcoholic fatty liver injury in mice

J. Fuscoe, T. Han, I. Pogribny, 2016, BMC Genomics.

Interstrain differences in the progression of nonalcoholic steatohepatitis to fibrosis in mice are associated with altered hepatic iron metabolism.

I. Pogribny, M. Pogribna, S. Ross, 2014, The Journal of nutritional biochemistry.

Modulation of Tetrachloroethylene-Associated Kidney Effects by Nonalcoholic Fatty Liver or Steatohepatitis in Male C57BL/6J Mice

I. Rusyn, I. Pogribny, D. Threadgill, 2018, Toxicological sciences : an official journal of the Society of Toxicology.

Epigenetic alterations in the brains of Fisher 344 rats induced by long-term administration of folate/methyl-deficient diet

T. Han, I. Pogribny, V. Tryndyak, 2008, Brain Research.

Chronic administration of 2-acetylaminofluorene alters the cellular iron metabolism in rat liver.

I. Koturbash, I. Pogribny, V. Tryndyak, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Overexpression of LINE-1 Retrotransposons in Autism Brain

I. Pogribny, S. Melnyk, O. Pavliv, 2018, Molecular Neurobiology.

Furan-induced transcriptomic and gene-specific DNA methylation changes in the livers of Fischer 344 rats in a 2-year carcinogenicity study

I. Pogribny, V. Tryndyak, F. Beland, 2017, Archives of Toxicology.

Coupling global methylation and gene expression profiles reveal key pathophysiological events in liver injury induced by a methyl-deficient diet.

J. Fuscoe, T. Han, I. Pogribny, 2011, Molecular nutrition & food research.

Effect of methionine-deficient and methionine-supplemented diets on the hepatic one-carbon and lipid metabolism in mice.

I. Pogribny, S. J. James, V. Tryndyak, 2014, Molecular nutrition & food research.

Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice.

I. Rusyn, I. Pogribny, V. Tryndyak, 2022, The Journal of nutritional biochemistry.

Epigenetic changes in the rat livers induced by pyrazinamide treatment.

T. Bagnyukova, I. Pogribny, O. Sergienko, 2007, Toxicology and applied pharmacology.

Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors.

I. Rusyn, I. Pogribny, Christine L. Powell, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Measurement of plasma and intracellular S-adenosylmethionine and S-adenosylhomocysteine utilizing coulometric electrochemical detection: alterations with plasma homocysteine and pyridoxal 5'-phosphate concentrations.

I. Pogribny, M. Pogribna, S. J. James, 2000, Clinical chemistry.

Presence and consequence of uracil in preneoplastic DNA from folate/methyl-deficient rats.

I. Pogribny, S. J. James, L. Muskhelishvili, 1997, Carcinogenesis.

Persistence of furan-induced epigenetic aberrations in the livers of F344 rats.

J. Fuscoe, T. Han, I. Pogribny, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

The role for microRNAs in drug toxicity and in safety assessment

I. Pogribny, F. Beland, A. Marrone, 2015, Expert opinion on drug metabolism & toxicology.

Intracellular S-adenosylhomocysteine concentrations predict global DNA hypomethylation in tissues of methyl-deficient cystathionine beta-synthase heterozygous mice.

I. Pogribny, S. J. James, M. Swendseid, 2001, The Journal of nutrition.

The DEN and CCl4‐Induced Mouse Model of Fibrosis and Inflammation‐Associated Hepatocellular Carcinoma

I. Rusyn, I. Pogribny, T. Uehara, 2014, Current protocols in pharmacology.

Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition.

M. Rudnicki, Zhoutao Chen, I. Pogribny, 2001, Human molecular genetics.

Measurement of Plasma and Intracellular S–Adenosylmethionine and S–Adenosylhomocysteine Utilizing Coulometric Electrochemical Detection: Alterations with Plasma Homocysteine and Pyridoxal 5'–Phosphate. Concentrations

I. Pogribny, M. Pogribna, S. J. James, 2000 .

Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats.

L. Poirier, I. Pogribny, A. Basnakian, 1995, Cancer research.

Gene expression and DNA methylation alterations in the glycine N-methyltransferase gene in diet-induced nonalcoholic fatty liver disease-associated carcinogenesis.

I. Rusyn, I. Pogribny, A. Sanyal, 2019, Toxicological sciences : an official journal of the Society of Toxicology.

Epigenetically mediated inhibition of S‐adenosylhomocysteine hydrolase and the associated dysregulation of 1‐carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma

I. Rusyn, I. Pogribny, M. Pogribna, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Genotoxic, epigenetic, and transcriptomic effects of tamoxifen in mouse liver.

I. Pogribny, V. Tryndyak, L. Muskhelishvili, 2014, Toxicology.

Strain‐dependent dysregulation of one‐carbon metabolism in male mice is associated with choline‐ and folate‐deficient diet‐induced liver injury

I. Rusyn, I. Pogribny, M. Pogribna, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Role of epigenetic and miR‐22 and miR‐29b alterations in the downregulation of Mat1a and Mthfr genes in early preneoplastic livers in rats induced by 2‐acetylaminofluorene

I. Koturbash, I. Pogribny, S. J. James, 2013, Molecular carcinogenesis.

Induction of oxidative stress and DNA damage in rat brain by a folate/methyl-deficient diet

T. Bagnyukova, I. Pogribny, Christine L. Powell, 2008, Brain Research.

Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver.

I. Rusyn, T. Bagnyukova, I. Pogribny, 2008, Mutation research.

Epigenetic reprogramming of liver cells in tamoxifen‐induced rat hepatocarcinogenesis

O. Kovalchuk, I. Pogribny, S. Ross, 2007, Molecular carcinogenesis.

Abnormal folate metabolism and genetic polymorphism of the folate pathway in a child with Down syndrome and neural tube defect.

I. Pogribny, M. Pogribna, S. J. James, 2001, American journal of medical genetics.

Homocysteine metabolism in children with Down syndrome: in vitro modulation.

I. Pogribny, M. Pogribna, S. J. James, 2001, American journal of human genetics.

Increase in Plasma Homocysteine Associated with Parallel Increases in Plasma S-Adenosylhomocysteine and Lymphocyte DNA Hypomethylation*

I. Pogribny, M. Pogribna, S. J. James, 2000, The Journal of Biological Chemistry.

Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome.

V. L. Wilson, D. Gaylor, I. Pogribny, 1999, The American journal of clinical nutrition.

A new HPLC method for the simultaneous determination of oxidized and reduced plasma aminothiols using coulometric electrochemical detection.

I. Pogribny, M. Pogribna, S. J. James, 1999, The Journal of nutritional biochemistry.

Trans-HHS Workshop : Diet , DNA Methylation Processes and Health Elevation in S-Adenosylhomocysteine and DNA Hypomethylation : Potential Epigenetic Mechanism for Homocysteine-Related Pathology 1

Stepan Melnyk, Igor P. Pogribny, I. Pogribny, 2002 .

Radiation-induced molecular changes in rat mammary tissue: Possible implications for radiation-induced carcinogenesis

O. Kovalchuk, I. Koturbash, I. Pogribny, 2006, International journal of radiation biology.

Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice.

Ivan Rusyn, Eric F Lock, Oksana Kosyk, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Alterations of microRNAs and their targets are associated with acquired resistance of MCF‐7 breast cancer cells to cisplatin

Andrey Golubov, Olga Kovalchuk, O. Kovalchuk, 2010, International journal of cancer.

Epigenetic aspects of genotoxic and non‐genotoxic hepatocarcinogenesis: Studies in rodents

I. Rusyn, I. Pogribny, F. Beland, 2008, Environmental and molecular mutagenesis.

Estrogen-Induced Rat Breast Carcinogenesis is Characterized by Alterations in DNA Methylation, Histone Modifications, and Aberrant microRNA Expression

O. Kovalchuk, I. Pogribny, V. Tryndyak, 2007, Cell cycle.

Noncoding RNA response to xenobiotic exposure: an indicator of toxicity and carcinogenicity

I. Pogribny, F. Beland, A. Marrone, 2014, Expert opinion on drug metabolism & toxicology.

Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: An update of a systematic literature review.

I. Rusyn, I. Pogribny, K. Guyton, 2021, Mutation research. Reviews in mutation research.

Considering Maternal Dietary Modulators for Epigenetic Regulation and Programming of the Fetal Epigenome

I. Pogribny, A. Chango, 2015, Nutrients.

Genomic hypomethylation is specific for preneoplastic liver in folate/methyl deficient rats and does not occur in non-target tissues.

I. Pogribny, M. Pogribna, S. J. James, 2004, Mutation research.

Sex- and tissue-specific expression of maintenance and de novo DNA methyltransferases upon low dose X-irradiation in mice.

O. Kovalchuk, I. Pogribny, Rocio Rodriguez-Juarez, 2004, Biochemical and biophysical research communications.

Mechanisms of DNA damage, DNA hypomethylation, and tumor progression in the folate/methyl-deficient rat model of hepatocarcinogenesis.

I. Pogribny, M. Pogribna, S. J. James, 2003, The Journal of nutrition.

Role of epigenetic aberrations in the development and progression of human hepatocellular carcinoma.

I. Rusyn, I. Pogribny, 2014, Cancer letters.

DNA methylome alterations in chemical carcinogenesis.

I. Pogribny, F. Beland, Frederick A Beland, 2013, Cancer letters.

Epigenetic Modifications in Chemical Carcinogenesis

I. Koturbash, I. Pogribny, F. Beland, 2012 .

Role of ferritin alterations in human breast cancer cells

O. Kovalchuk, I. Pogribny, V. Tryndyak, 2011, Breast Cancer Research and Treatment.

De novo methylation of the p16INK4A gene in early preneoplastic liver and tumors induced by folate/methyl deficiency in rats.

I. Pogribny, S. J. James, S. James, 2002, Cancer letters.

Molecular alterations in hepatocarcinogenesis induced by dietary methyl deficiency.

I. Pogribny, S. J. James, F. Beland, 2012, Molecular nutrition & food research.

DNA hypomethylation in the origin and pathogenesis of human diseases

I. Pogribny, F. Beland, 2009, Cellular and Molecular Life Sciences.

Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location

George R. Douglas, Andrew Williams, Carole Yauk, 2008, Proceedings of the National Academy of Sciences.

Epigenetic dysregulation underlies radiation-induced transgenerational genome instability in vivo.

O. Kovalchuk, I. Koturbash, I. Pogribny, 2006, International journal of radiation oncology, biology, physics.

Age-Related Genomic Hypomethylation

I. Pogribny, B. Vanyushin, 2010 .

Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl deficiency in rats.

L. Poirier, I. Pogribny, M. Pogribna, 2006, Carcinogenesis.

Modulation of intracellular iron metabolism by iron chelation affects chromatin remodeling proteins and corresponding epigenetic modifications in breast cancer cells and increases their sensitivity to chemotherapeutic agents.

I. Pogribny, M. Pogribna, V. Tryndyak, 2013, International journal of oncology.

Methyl deficiency, alterations in global histone modifications, and carcinogenesis.

I. Rusyn, I. Pogribny, S. Ross, 2007, The Journal of nutrition.

A sensitive new method for rapid detection of abnormal methylation patterns in global DNA and within CpG islands.

I. Pogribny, S. J. James, P. Yi, 1999, Biochemical and biophysical research communications.

In vivo bystander effect: cranial X-irradiation leads to elevated DNA damage, altered cellular proliferation and apoptosis, and increased p53 levels in shielded spleen.

O. Kovalchuk, I. Koturbash, I. Pogribny, 2008, International journal of radiation oncology, biology, physics.

Stable loss of global DNA methylation in the radiation-target tissue--a possible mechanism contributing to radiation carcinogenesis?

O. Kovalchuk, I. Koturbash, I. Pogribny, 2005, Biochemical and biophysical research communications.

Fractionated Low-Dose Radiation Exposure Leads to Accumulation of DNA Damage and Profound Alterations in DNA and Histone Methylation in the Murine Thymus

O. Kovalchuk, I. Koturbash, I. Pogribny, 2005, Molecular Cancer Research.

MicroRNAs as biomarkers for clinical studies

I. Pogribny, Igor P Pogribny, 2018, Experimental biology and medicine.

Role of microRNAs in the regulation of drug metabolizing and transporting genes and the response to environmental toxicants

I. Koturbash, I. Pogribny, F. Beland, 2012, Expert opinion on drug metabolism & toxicology.

The role of epigenetic events in genotoxic hepatocarcinogenesis induced by 2-acetylaminofluorene.

I. Pogribny, V. Tryndyak, L. Muskhelishvili, 2011, Mutation research.

MicroRNA dysregulation during chemical carcinogenesis.

I. Pogribny, 2009, Epigenomics.

The tumor-promoting activity of 2-acetylaminofluorene is associated with disruption of the p53 signaling pathway and the balance between apoptosis and cell proliferation.

I. Pogribny, V. Tryndyak, L. Muskhelishvili, 2009, Toxicology and applied pharmacology.

Induction of microRNAome deregulation in rat liver by long-term tamoxifen exposure.

O. Kovalchuk, I. Pogribny, V. Tryndyak, 2007, Mutation research.

MicroRNAs in normal and cancer cells: a new class of gene expression regulators.

T. Bagnyukova, I. Pogribny, Chekhun Vf, 2006, Experimental oncology.

A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats.

K. Ghoshal, J. Datta, S. Jacob, 2006, The Journal of nutrition.

Methyl deficiency causes reduction of the methyl-CpG-binding protein, MeCP2, in rat liver.

I. Pogribny, S. J. James, Joshua W. Miller, 2003, Carcinogenesis.

Betaine rescue of an animal model with methylenetetrahydrofolate reductase deficiency.

Zhoutao Chen, I. Pogribny, R. Rozen, 2004, The Biochemical journal.

An in vitro investigation of metabolically sensitive biomarkers in breast cancer progression

I. Pogribny, V. Tryndyak, F. Beland, 2012, Breast Cancer Research and Treatment.

MicroRNA-mediated drug resistance in breast cancer

I. Pogribny, O. Yurchenko, F. Beland, 2011, Clinical Epigenetics.

Iron metabolism disturbances in the MCF-7 human breast cancer cells with acquired resistance to doxorubicin and cisplatin.

I. Pogribny, V. Tryndyak, F. Beland, 2013, International journal of oncology.

Uracil misincorporation, DNA strand breaks, and gene amplification are associated with tumorigenic cell transformation in folate deficient/repleted Chinese hamster ovary cells.

I. Pogribny, A. Basnakian, M. Pogribna, 1999, Cancer letters.

The role of UDP-glucuronosyltransferases and drug transporters in breast cancer drug resistance.

I. Pogribny, F. Beland, B. Lyn‐Cook, 2010, Experimental oncology.

Nutritional Epigenetics and the Prevention of Hepatocellular Carcinoma with Bioactive Food Constituents

I. Pogribny, F. Moreno, R. Heidor, 2016, Nutrition and cancer.

The chemopreventive activity of butyrate-containing structured lipids in experimental rat hepatocarcinogenesis.

I. Pogribny, E. Purgatto, L. A. Gioielli, 2016, Molecular nutrition & food research.

Mechanisms of epigenetic silencing of the Rassf1a gene during estrogen-induced breast carcinogenesis in ACI rats.

I. Pogribny, V. Tryndyak, F. Beland, 2010, Carcinogenesis.

Epigenetic profiling of multidrug-resistant human MCF-7 breast adenocarcinoma cells reveals novel hyper- and hypomethylated targets

O. Kovalchuk, I. Pogribny, V. Tryndyak, 2007, Molecular Cancer Therapeutics.

Dose-dependence, sex- and tissue-specificity, and persistence of radiation-induced genomic DNA methylation changes.

Igor Pogribny, Olga Kovalchuk, O. Kovalchuk, 2004, Biochemical and biophysical research communications.

Molecular Aspects of Plant Adaptation to Life in the Chernobyl Zone1[w]

O. Kovalchuk, I. Pogribny, I. Kovalchuk, 2004, Plant Physiology.

Genome hypermethylation in Pinus silvestris of Chernobyl--a mechanism for radiation adaptation?

O. Kovalchuk, I. Pogribny, S. J. James, 2003, Mutation research.

Role of epigenetic effectors in maintenance of the long-term persistent bystander effect in spleen in vivo.

R. J. McDonald, O. Kovalchuk, I. Koturbash, 2007, Carcinogenesis.

Multiplex PCR for simultaneous detection of 677 C-->T and 1298 A-->C polymorphisms in methylenetetrahydrofolate reductase gene for population studies of cancer risk.

I. Pogribny, P. Yi, S. Jill James, 2002, Cancer letters.

E‐cadherin transcriptional down‐regulation by epigenetic and microRNA‐200 family alterations is related to mesenchymal and drug‐resistant phenotypes in human breast cancer cells

I. Pogribny, V. Tryndyak, F. Beland, 2010, International journal of cancer.

Ferroportin and hepcidin: a new hope in diagnosis, prognosis, and therapy for breast cancer

I. Pogribny, Igor P Pogribny, 2010, Breast Cancer Research.

Cerebellar Oxidative DNA Damage and Altered DNA Methylation in the BTBR T+tf/J Mouse Model of Autism and Similarities with Human Post Mortem Cerebellum

I. Pogribny, S. J. James, V. Tryndyak, 2014, PloS one.

Status of hepatic DNA methylome predetermines and modulates the severity of non-alcoholic fatty liver injury in mice

J. Fuscoe, T. Han, I. Pogribny, 2016, BMC Genomics.

Genotoxic and Epigenotoxic Alterations in the Lung and Liver of Mice Induced by Acrylamide: A 28 Day Drinking Water Study.

I. Pogribny, V. Tryndyak, M. Churchwell, 2019, Chemical research in toxicology.

Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein

I. Pogribny, M. Pogribna, V. Tryndyak, 2016, Oncotarget.

Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet

I. Rusyn, I. Pogribny, A. Sanyal, 2022, Epigenetics.

Alterations in hepatic p53 gene methylation patterns during tumor progression with folate/methyl deficiency in the rat.

I. Pogribny, S. J. James, B. J. Miller, 1997, Cancer letters.

Irradiation induces DNA damage and modulates epigenetic effectors in distant bystander tissue in vivo

Carrie A. Hendricks, O. Kovalchuk, I. Koturbash, 2006, Oncogene.

Methylation changes in muscle and liver tissues of male and female mice exposed to acute and chronic low-dose X-ray-irradiation.

O. Kovalchuk, J. Filkowski, I. Pogribny, 2004, Mutation research.

Elevated 5-hydroxymethylcytosine in the Engrailed-2 (EN-2) promoter is associated with increased gene expression and decreased MeCP2 binding in autism cerebellum

I. Pogribny, S. J. James, S. Melnyk, 2014, Translational Psychiatry.

Alterations in histone H4 lysine 20 methylation: implications for cancer detection and prevention.

I. Koturbash, I. Pogribny, F. Beland, 2012, Antioxidants & redox signaling.

Gene Expression and DNA Methylation Alterations During Non-alcoholic Steatohepatitis-Associated Liver Carcinogenesis

I. Pogribny, V. Tryndyak, F. Beland, 2019, Front. Genet..

Imbalance between apoptosis and cell proliferation during early stages of mammary gland carcinogenesis in ACI rats.

O. Kovalchuk, I. Koturbash, I. Pogribny, 2010, Mutation research.

Transgenerational changes in the genome stability and methylation in pathogen-infected plants

I. Pogribny, F. Zemp, I. Kovalchuk, 2007, Nucleic acids research.

Differentially expressed MicroRNAs provide mechanistic insight into fibrosis‐associated liver carcinogenesis in mice

I. Rusyn, I. Pogribny, T. Uehara, 2016, Molecular carcinogenesis.

Modifying metabolically sensitive histone marks by inhibiting glutamine metabolism affects gene expression and alters cancer cell phenotype

I. Pogribny, M. Pogribna, V. Tryndyak, 2012, Epigenetics.

Role of epigenetic events in chemical carcinogenesis—a justification for incorporating epigenetic evaluations in cancer risk assessment

I. Koturbash, I. Pogribny, F. Beland, 2011, Toxicology mechanisms and methods.

Epigenetic events in tumorigenesis: putting the pieces together.

I. Pogribny, 2010, Experimental oncology.

Epigenetic effects of low-level sodium arsenite exposure on human liver HepaRG cells

I. Pogribny, V. Tryndyak, F. Beland, 2020, Archives of Toxicology.

MicroRNA Responses to the Genotoxic Carcinogens Aflatoxin B1 and Benzo[a]pyrene in Human HepaRG Cells.

I. Pogribny, V. Tryndyak, F. Beland, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

Complex epigenetic regulation of Engrailed-2 (EN-2) homeobox gene in the autism cerebellum

Stepan Melnyk, I. Pogribny, S. J. James, 2013, Translational Psychiatry.

Epigenetic events determine tissue-specific toxicity of inhalational exposure to the genotoxic chemical 1,3-butadiene in male C57BL/6J mice.

I. Rusyn, I. Pogribny, N. Tretyakova, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Comparative analysis of promoter methylation and gene expression endpoints between tumorous and non-tumorous tissues from HCV-positive patients with hepatocellular carcinoma.

I. Rusyn, I. Pogribny, H. Fujii, 2010, Mutation research.

A method to estimate the percent loss of cytosine methyl groups at defined CpG sites in liver DNA from methyl-deficient rats

I. Pogribny, S. J. James, 1997 .

Identification of differentially methylated sites within unmethylated DNA domains in normal and cancer cells.

O. Kovalchuk, I. Pogribny, V. Tryndyak, 2006, Analytical biochemistry.

Paternal cranial irradiation induces distant bystander DNA damage in the germline and leads to epigenetic alterations in the offspring

R. Sutherland, O. Kovalchuk, Jan Tamminga, 2008, Cell cycle.

Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency.

L. Poirier, Y. Dragan, I. Pogribny, 2006, Mutation research.

Chemo brain or tumor brain - that is the question: the presence of extracranial tumors profoundly affects molecular processes in the prefrontal cortex of TumorGraft mice

B. Kolb, O. Kovalchuk, Y. Ilnytskyy, 2017, Aging.

Research Articles The methylenetetrahydrofolate reductase 677TT genotype and folate intake interact to lower global leukocyte DNA methylation in young Mexican American women B

I. Pogribny, M. Caudill, Steven S. Smith, 2007 .

The methylenetetrahydrofolate reductase 677TT genotype and folate intake interact to lower global leukocyte DNA methylation in young Mexican American women

Igor P. Pogribny, I. Pogribny, M. Caudill, 2007 .

The MTHFR 677TT genotype and folate intake interact to lower global leukocyte DNA methylation in young Mexican American women.

I. Pogribny, M. Caudill, Steven S. Smith, 2007, Nutrition research.

Role of DNA damage and alterations in cytosine DNA methylation in rat liver carcinogenesis induced by a methyl-deficient diet.

T. Bagnyukova, I. Pogribny, S. J. James, 2009, Mutation research.

Epigenetic down-regulation of the suppressor of cytokine signaling 1 (Socs1) gene is associated with the STAT3 activation and development of hepatocellular carcinoma induced by methyl-deficiency in rats

T. Bagnyukova, I. Pogribny, S. Ross, 2008, Cell cycle.

Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis.

I. Rusyn, I. Pogribny, R. Bataller, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

DNA methylation in Folbp1 knockout mice supplemented with folic acid during gestation.

I. Pogribny, B. Wlodarczyk, R. Finnell, 2002, The Journal of nutrition.

Alterations in DNA Methylation Resulting from Exposure to Chemical Carcinogens

I. Pogribny, F. Beland, T. Kobets, 2014 .

Dietary Factors, Histone Modifications, and Cancer Prevention

I. Koturbash, I. Pogribny, S. Ross, 2010 .

Epigenetic mechanisms of mouse interstrain variability in genotoxicity of the environmental toxicant 1,3-butadiene.

I. Rusyn, I. Koturbash, I. Pogribny, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Quantitative comparison of in vitro genotoxicity between metabolically competent HepaRG cells and HepG2 cells using the high-throughput high-content CometChip assay

N. Mei, I. Pogribny, V. Tryndyak, 2019, Archives of Toxicology.

Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet.

I. Rusyn, I. Pogribny, S. Ross, 2012, Toxicology and applied pharmacology.

Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans

W. Xiao, Tieliu Shi, Leming Shi, 2018, Archives of Toxicology.

' s personal copy Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline-and folate-de fi cient diet ☆

I. Rusyn, I. Pogribny, S. Ross, 2012 .

S-Adenosylhomocysteine hydrolase deficiency in a 26-year-old man

I. Pogribny, S. Zeisel, A. Schulze, 2006, Journal of Inherited Metabolic Disease.

Abstract 5601: The role of UDP-Glucuronosyltransferases in human breast cancers

I. Pogribny, B. Lyn‐Cook, A. Starlard-Davenport, 2011 .

miR-1247 blocks SOX9-mediated regeneration in alcohol- and fibrosis-associated acute kidney injury in mice.

I. Rusyn, I. Pogribny, F. Beland, 2017, Toxicology.

Role of microRNAs in the regulation of drug metabolism and disposition genes in diabetes and liver disease

I. Pogribny, F. Beland, 2013, Expert opinion on drug metabolism & toxicology.

PubMed articles by these authors

I. Pogribny, M. Pogribna, S. J. James, 2001 .

Epigenetic Alterations in Liver of C57BL/6J Mice after Short-Term Inhalational Exposure to 1,3-Butadiene

I. Rusyn, I. Koturbash, I. Pogribny, 2010, Environmental health perspectives.

Chronic administration of ethanol leads to an increased incidence of hepatocellular adenoma by promoting H-ras-mutated cells.

I. Rusyn, I. Pogribny, F. Beland, 2011, Cancer letters.

Genetic and epigenetic changes in fibrosis‐associated hepatocarcinogenesis in mice

I. Rusyn, I. Pogribny, T. Uehara, 2014, International journal of cancer.

Suppression of CYP2C9 by MicroRNA hsa-miR-128-3p in Human Liver Cells and Association with Hepatocellular Carcinoma

J. Fuscoe, B. Ning, I. Pogribny, 2015, Scientific Reports.

Population-Based Analysis of DNA Damage and Epigenetic Effects of 1,3-Butadiene in the Mouse.

I. Rusyn, F. Wright, I. Pogribny, 2019, Chemical research in toxicology.

Editor’s Highlight: Organ-Specific Epigenetic Changes Induced by the Nongenotoxic Liver Carcinogen Methapyrilene in Fischer 344 Rats

Tao Chen, I. Pogribny, Jian Yan, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

The role of microRNAs in the development and progression of chemical-associated cancers.

Ivan Rusyn, I. Rusyn, I. Pogribny, 2016, Toxicology and applied pharmacology.

Benzo[a]pyrene (BP) DNA adduct formation in DNA repair-deficient p53 haploinsufficient [Xpa(-/-)p53(+/-)] and wild-type mice fed BP and BP plus chlorophyllin for 28 days.

I. Pogribny, M. Churchwell, F. Beland, 2012, Carcinogenesis.

Tumorigenicity of acrylamide and its metabolite glycidamide in the neonatal mouse bioassay

I. Koturbash, I. Pogribny, F. Beland, 2012, International journal of cancer.

New insights into the molecular mechanisms of chemical carcinogenesis: In vivo adduction of histone H2B by a reactive metabolite of the chemical carcinogen furan.

I. Pogribny, F. Beland, C. Jacob, 2016, Toxicology letters.

Gene expression profiling reveals underlying molecular mechanisms of the early stages of tamoxifen-induced rat hepatocarcinogenesis.

O. Kovalchuk, J. Fuscoe, T. Han, 2007, Toxicology and applied pharmacology.

Interstrain differences in the severity of liver injury induced by a choline‐ and folate‐deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism

I. Rusyn, J. Fuscoe, T. Han, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Aloe vera Non-Decolorized Whole Leaf Extract-Induced Large Intestinal Tumors in F344 Rats Share Similar Molecular Pathways with Human Sporadic Colorectal Tumors

I. Pogribny, S. Peddada, M. Hoenerhoff, 2011, Toxicologic pathology.

Prior exposure to oxidized low-density lipoprotein limits apoptosis in subsequent generations of endothelial cells by altering promoter methylation.

J. Mehta, I. Pogribny, M. Khaidakov, 2011, American journal of physiology. Heart and circulatory physiology.

Impact of Nonalcoholic Fatty Liver Disease on Toxicokinetics of Tetrachloroethylene in Mice

I. Rusyn, I. Pogribny, D. Threadgill, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Nonalcoholic Fatty Liver Disease Is a Susceptibility Factor for Perchloroethylene-Induced Liver Effects in Mice

I. Rusyn, I. Pogribny, D. Threadgill, 2017, Toxicological sciences : an official journal of the Society of Toxicology.

Dietary Methyl Deficiency, microRNA Expression and Susceptibility to Liver Carcinogenesis

I. Rusyn, I. Pogribny, O. Kosyk, 2011, Lifestyle Genomics.

Dietary methyl deficiency, microRNA expression and susceptibility to liver carcinogenesis.

I. Rusyn, I. Pogribny, O. Kosyk, 2010, World review of nutrition and dietetics.

Differential expression of microRNAs during hepatocarcinogenesis induced by methyl deficiency in rats.

I. Pogribny, S. Ross, V. Tryndyak, 2008, Nutrition reviews.

Irreversible down-regulation of miR-375 in the livers of Fischer 344 rats after chronic furan exposure.

I. Pogribny, V. Tryndyak, F. Beland, 2016, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.