C. Ruppert

发表

Pivotal Role of Matrix Metalloproteinase 13 in Extracellular Matrix Turnover in Idiopathic Pulmonary Fibrosis

Takwi Nkyimbeng, C. Ruppert, T. Shiomi, 2013, PloS one.

FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis

R. DePinho, C. Ruppert, W. Seeger, 2017, EMBO molecular medicine.

Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension

C. Ruppert, W. Seeger, S. Pullamsetti, 2019, Nature Communications.

Is the fibroblast growth factor signaling pathway a victim of receptor tyrosine kinase inhibition in pulmonary parenchymal and vascular remodeling?

C. Ruppert, A. Günther, R. Schermuly, 2018, American journal of physiology. Lung cellular and molecular physiology.

FK506-Binding Protein 11 Is a Novel Plasma Cell-Specific Antibody Folding Catalyst with Increased Expression in Idiopathic Pulmonary Fibrosis

C. Ruppert, N. Kaminski, E. Meinl, 2022, Cells.

Keratinocyte growth factor prevents intra-alveolar oedema in experimental lung isografts

C. Ruppert, A. Günther, J. Hohlfeld, 2008, European Respiratory Journal.

Prevention of bleomycin-induced lung fibrosis by aerosolization of heparin or urokinase in rabbits.

C. Ruppert, W. Seeger, A. Günther, 2003, American journal of respiratory and critical care medicine.

Unravelling the progressive pathophysiology of idiopathic pulmonary fibrosis

C. Ruppert, A. Günther, P. Markart, 2012, European Respiratory Review.

Surfactant protein C mutations in sporadic forms of idiopathic interstitial pneumonias

C. Ruppert, W. Seeger, A. Guenther, 2006, European Respiratory Journal.

Reduction of chronic hypoxic pulmonary hypertension in the rat by an inhibitor of collagen production.

C. Ruppert, D. J. Riley, C. Tozzi, 1987, The American review of respiratory disease.

Biophysical investigation of pulmonary surfactant surface properties upon contact with polymeric nanoparticles in vitro.

C. Ruppert, W. Seeger, A. Guenther, 2011, Nanomedicine : nanotechnology, biology, and medicine.

Ischemic and endotoxin pre-conditioning reduce lung reperfusion injury-induced surfactant alterations.

C. Ruppert, A. Günther, R. Silber, 2005, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Patients with ARDS show improvement but not normalisation of alveolar surface activity with surfactant treatment: putative role of neutral lipids

C. Ruppert, B. Dahal, W. Seeger, 2007, Thorax.

Selective inhibition of large-to-small surfactant aggregate conversion by serine protease inhibitors of the bis-benzamidine type.

C. Ruppert, W. Seeger, A. Günther, 2003, American journal of respiratory cell and molecular biology.

Alveolar oxidative stress is associated with elevated levels of nonenzymatic low-molecular-weight antioxidants in patients with different forms of chronic fibrosing interstitial lung diseases.

C. Ruppert, W. Seeger, A. Guenther, 2009, Antioxidants & redox signaling.

Aberrant expression and activity of histone deacetylases in sporadic idiopathic pulmonary fibrosis

C. Ruppert, W. Seeger, S. Pullamsetti, 2015, Thorax.

Medicines to treat fibrotic lung diseases

C. Ruppert, W. Seeger, A. Günther, 2007 .

Regulation of Immunoproteasome Function in the Lung

C. Ruppert, A. Günther, S. Takenaka, 2015, Scientific Reports.

Susceptibility of microtubule‐associated protein 1 light chain 3β (MAP1LC3B/LC3B) knockout mice to lung injury and fibrosis

C. Ruppert, W. Seeger, M. Ochs, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Regulation and role of the ER stress transcription factor CHOP in alveolar epithelial type-II cells

C. Ruppert, W. Seeger, C. Samakovlis, 2019, Journal of Molecular Medicine.

Comparison of the antifibrotic effects of the pan-histone deacetylase-inhibitor panobinostat versus the IPF-drug pirfenidone in fibroblasts from patients with idiopathic pulmonary fibrosis

C. Ruppert, W. Seeger, S. Pullamsetti, 2018, PloS one.

Tissue remodelling in pulmonary fibrosis

C. Ruppert, M. Ochs, L. Knudsen, 2017, Cell and Tissue Research.

Alveolar fibrin formation caused by enhanced procoagulant and depressed fibrinolytic capacities in severe pneumonia. Comparison with the acute respiratory distress syndrome.

C. Ruppert, W. Seeger, A. Günther, 2000, American journal of respiratory and critical care medicine.

Cellular origin of pro-coagulant and (anti)-fibrinolytic factors in bleomycin-injured lungs

K. Preissner, C. Ruppert, W. Seeger, 2007, European Respiratory Journal.

Surfactant alteration and replacement in acute respiratory distress syndrome

C. Ruppert, W. Seeger, A. Günther, 2001, Respiratory research.

Enhanced Tissue Factor Pathway Activity and Fibrin Turnover in the Alveolar Compartment of Patients with Interstitial Lung Disease

C. Ruppert, W. Seeger, A. Günther, 2000, Thrombosis and Haemostasis.

Cell-Specific Nitric Oxide Synthase-Isoenzyme Expression and Regulation in Response to Endotoxin in Intact Rat Lungs

C. Ruppert, W. Seeger, A. Günther, 2002, Laboratory Investigation.

Epigenetic reactivation of transcriptional programs orchestrating fetal lung development in human pulmonary hypertension

C. Ruppert, R. Rottier, S. Pullamsetti, 2022, Science Translational Medicine.

Surfactant inhibits ATP-induced release of interleukin-1β via nicotinic acetylcholine receptors[S]

C. Ruppert, W. Padberg, J. McIntosh, 2017, Journal of Lipid Research.

WNT/RYK signaling functions as an antiinflammatory modulator in the lung mesenchyme

C. Ruppert, D. Stainier, Y. Nakamichi, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Compartment- and cell-specific expression of coagulation and fibrinolysis factors in the murine lung undergoing inhalational versus intravenous endotoxin application

C. Ruppert, W. Seeger, A. Günther, 2004, Thrombosis and Haemostasis.

Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension

C. Ruppert, A. Shah, R. Schermuly, 2019, Proceedings of the National Academy of Sciences of the United States of America.

An essential function for autocrine hedgehog signaling in epithelial proliferation and differentiation in the trachea

J. Koepke, C. Ruppert, W. Seeger, 2022, bioRxiv.

Cell-Surface Programmed Death Ligand-1 Expression Identifies a Sub-Population of Distal Epithelial Cells Enriched in Idiopathic Pulmonary Fibrosis

C. Ruppert, S. Bellusci, Farhad Khosravi, 2022, Cells.

Cell-surface PD-L1 expression identifies a sub-population of distal epithelial cells enriched in idiopathic pulmonary fibrosis

C. Ruppert, S. Bellusci, N. Baal, 2022, bioRxiv.

Alveolar antioxidant status in patients with acute respiratory distress syndrome

C. Ruppert, W. Seeger, A. Günther, 2004, European Respiratory Journal.

Cleavage of surfactant-incorporating fibrin by different fibrinolytic agents. Kinetics of lysis and rescue of surface activity.

C. Ruppert, W. Seeger, A. Günther, 1999, American journal of respiratory cell and molecular biology.

Single-cell RNA sequencing uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19

Leon N. Schulte, C. Ruppert, A. Gruber, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Time-dependent changes in pulmonary surfactant function and composition in acute respiratory distress syndrome due to pneumonia or aspiration

C. Ruppert, W. Seeger, A. Guenther, 2007, Respiratory research.

Pulmonary surfactant in patients with Pneumocystis pneumonia and acquired immunodeficiency syndrome

C. Ruppert, W. Seeger, A. Günther, 2006, Critical care medicine.

Targeting peptidyl-prolyl isomerase 1 in experimental pulmonary arterial hypertension

C. Ruppert, W. Seeger, H. Ghofrani, 2022, European Respiratory Journal.

Epithelial stress and apoptosis underlie Hermansky-Pudlak syndrome-associated interstitial pneumonia.

C. Ruppert, W. Seeger, S. Bellusci, 2010, American journal of respiratory and critical care medicine.

Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling

C. Ruppert, A. Günther, V. Vijayan, 2015, Proceedings of the National Academy of Sciences.

Fibrinolysis-inhibitory capacity of clot-embedded surfactant is enhanced by SP-B and SP-C.

C. Ruppert, W. Seeger, A. Günther, 2003, American journal of physiology. Lung cellular and molecular physiology.

Alveolar Micromechanics in Bleomycin‐induced Lung Injury

Bradford J. Smith, J. Bates, C. Ruppert, 2018, American journal of respiratory cell and molecular biology.

Positive End-Expiratory Pressure Modifies Response to Recombinant and Natural Exogenous Surfactant in Ventilated Immature Newborn Rabbits

C. Ruppert, A. Günther, L. Gortner, 2006, Neonatology.

Effects of a recombinant surfactant protein-C-based surfactant on lung function and the pulmonary surfactant system in a model of meconium aspiration syndrome*

C. Ruppert, A. Günther, L. Gortner, 2006, Critical care medicine.

Changes in pulmonary surfactant function and composition in bleomycin-induced pneumonitis and fibrosis.

C. Ruppert, W. Seeger, A. Günther, 2004, Toxicology and applied pharmacology.

Impact of surface tension on the conversion rate of large to small surfactant aggregates.

C. Ruppert, W. Seeger, A. Günther, 2003, Biophysical chemistry.

Biophysical inhibition of pulmonary surfactant function by polymeric nanoparticles: role of surfactant protein B and C.

C. Ruppert, W. Seeger, A. Günther, 2014, Acta biomaterialia.

Biophysical inhibition of synthetic vs. naturally-derived pulmonary surfactant preparations by polymeric nanoparticles.

C. Ruppert, W. Seeger, A. Günther, 2014, Biochimica et biophysica acta.

Role of coagulation and fibrinolysis in lung and renal fibrosis.

K. Preissner, C. Ruppert, A. Günther, 2008, Hamostaseologie.

Dry powder aerosolization of a recombinant surfactant protein-C–based surfactant for inhalative treatment of the acutely inflamed lung*

C. Ruppert, W. Seeger, A. Günther, 2010, Critical care medicine.

Surfactant replacement and open lung concept – Comparison of two treatment strategies in an experimental model of neonatal ARDS

C. Ruppert, L. Gortner, M. Ebsen, 2008, BMC pulmonary medicine.

Patients with ARDS show incomplete restoration of alveolar surface activity upon recombinant SPC-based surfactant treatment : putative role of neutral lipids

C. Ruppert, B. Dahal, W. Seeger, 2007 .

Liver carboxylesterase cleaves surfactant protein (SP-) B and promotes surfactant subtype conversion.

C. Ruppert, W. Seeger, A. Günther, 2006, Biochemical and biophysical research communications.

Bronchoscopic administration of bovine natural surfactant in ARDS and septic shock: impact on biophysical and biochemical surfactant properties

C. Ruppert, W. Seeger, A. Günther, 2002, European Respiratory Journal.

Induction of tissue factor by urokinase in lung epithelial cells and in the lungs.

C. Ruppert, E. Abraham, S. Shetty, 2010, American journal of respiratory and critical care medicine.

Quantitative proteomics of differentiated primary bronchial epithelial cells from chronic obstructive pulmonary disease and control identifies potential novel host factors post-influenza A virus infection

C. Ruppert, S. Hauck, H. Adler, 2023, Frontiers in Microbiology.

Statistical biases due to anonymization evaluated in an open clinical dataset from COVID-19 patients

Marcus M. Scheunemann, Lennart M. Reinke, J. Papenbrock, 2022, Scientific data.

Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation

K. Preissner, C. Ruppert, A. Günther, 2007, Proceedings of the National Academy of Sciences.

MAP1LC3B overexpression protects against Hermansky-Pudlak syndrome type-1-induced defective autophagy in vitro.

C. Ruppert, W. Seeger, S. Bellusci, 2016, American journal of physiology. Lung cellular and molecular physiology.

Translational Research in Acute Lung Injury and Pulmonary Fibrosis MAP 1 LC 3 B overexpression protects against Hermansky-Pudlak syndrome type-1-induced defective autophagy in vitro

C. Ruppert, W. Seeger, S. Bellusci, 2016 .

BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics

C. Ruppert, R. Haag, K. Blank, 2019, PLoS biology.

Transcriptional Profiling of Insulin-like Growth Factor Signaling Components in Embryonic Lung Development and Idiopathic Pulmonary Fibrosis

C. Ruppert, S. Herold, M. Wygrecka, 2022, Cells.

The role of Endoplasmic Reticulum (ER) stress in pulmonary fibrosis

C. Ruppert, A. Guenther, M. Korfei, 2016 .

Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension

C. Ruppert, W. Seeger, S. Pullamsetti, 2019, Nature Communications.

Notch1 Induces Defective Epithelial Surfactant Processing and Pulmonary Fibrosis.

C. Ruppert, W. Seeger, R. Schermuly, 2022, American journal of respiratory and critical care medicine.

Notch3 Deficiency Attenuates Pulmonary Fibrosis and Impedes Lung Function Decline.

F. Prósper, C. Ruppert, J. Zulueta, 2021, American journal of respiratory cell and molecular biology.

Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells

C. Ruppert, H. Wiendl, S. Meuth, 2016, Nature Communications.

Noncanonical HIPPO/MST Signaling via BUB3 and FOXO Drives Pulmonary Vascular Cell Growth and Survival

C. Ruppert, S. Pullamsetti, S. Dabral, 2022, Circulation research.

Targeting Jak-Stat Signaling in Experimental Pulmonary Hypertension.

C. Ruppert, W. Seeger, A. Günther, 2020, American journal of respiratory cell and molecular biology.

Differential LysoTracker Uptake Defines Two Populations of Distal Epithelial Cells in Idiopathic Pulmonary Fibrosis

C. Ruppert, W. Seeger, S. Bellusci, 2021, Cells.

Depletion of activated macrophages with a folate receptor-beta-specific antibody improves symptoms in mouse models of rheumatoid arthritis

P. Low, C. Ruppert, D. Dimitrov, 2019, Arthritis Research & Therapy.

Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease

C. Ruppert, D. Stainier, M. Looso, 2018, bioRxiv.

Single cell RNA-seq uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19

Leon N. Schulte, C. Ruppert, A. Gruber, 2021 .

Loss of LRP1 promotes acquisition of contractile-myofibroblast phenotype and release of active TGF-β1 from ECM stores.

C. Ruppert, L. Schaefer, M. Wygrecka, 2019, Matrix biology : journal of the International Society for Matrix Biology.

Inhibition of urokinase activity reduces primary tumor growth and metastasis formation in a murine lung carcinoma model.

C. Ruppert, W. Seeger, A. Günther, 2010, American journal of respiratory and critical care medicine.

Recombinant production of a hybrid plasminogen activator composed of surfactant protein B and low-molecular-weight urokinase

K. Preissner, C. Ruppert, W. Seeger, 2008, Thrombosis and Haemostasis.

Chemical crosslinking of urokinase to pulmonary surfactant protein B for targeting alveolar fibrin

C. Ruppert, W. Seeger, A. Günther, 2003, Thrombosis and Haemostasis.

Chemical coupling of a monoclonal antisurfactant protein-B antibody to human urokinase for targeting surfactant-incorporating alveolar fibrin.

C. Ruppert, W. Seeger, A. Günther, 2002, Bioconjugate chemistry.

Restored alveolar epithelial differentiation and reversed human lung fibrosis upon Notch inhibition

C. Ruppert, W. Seeger, S. Bellusci, 2019, bioRxiv.

Transforming Growth Factor-β1 Regulates Peroxisomal Genes/Proteins via Smad Signaling in Idiopathic Pulmonary Fibrosis Fibroblasts and Transgenic Mouse Models.

C. Ruppert, M. Bartkuhn, S. Karnati, 2022, The American journal of pathology.

Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosis.

C. Ruppert, W. Seeger, R. Bohle, 2008, American journal of respiratory and critical care medicine.

Angiotensin II receptor blocker intake associates with reduced markers of inflammatory activation and decreased mortality in patients with cardiovascular comorbidities and COVID-19 disease

C. Ruppert, S. Ciesek, A. Zeiher, 2021, PloS one.

Follicular Helper–like T Cells in the Lung Highlight a Novel Role of B Cells in Sarcoidosis

C. Ruppert, M. Mashreghi, L. Sander, 2021, American journal of respiratory and critical care medicine.

Cancer cachexia alters intracellular surfactant metabolism but not total alveolar surface area

C. Ruppert, G. Krasteva, C. Mühlfeld, 2012, Histochemistry and Cell Biology.

Safety and tolerability of inhaled heparin in idiopathic pulmonary fibrosis.

C. Ruppert, W. Seeger, A. Guenther, 2010, Journal of aerosol medicine and pulmonary drug delivery.

Regulation of macroautophagy in amiodarone‐induced pulmonary fibrosis

C. Ruppert, W. Seeger, M. Ochs, 2015, The journal of pathology. Clinical research.

Extracellular collagenase, proteoglycanase and products of their activity, released in organ culture by intact dermal inflammatory lesions produced by sulfur mustard.

C. Ruppert, J. Woessner, N. Dahms, 1990, The Journal of investigative dermatology.

Comparative proteomic analysis of lung tissue from patients with idiopathic pulmonary fibrosis (IPF) and lung transplant donor lungs.

K. Preissner, C. Ruppert, W. Seeger, 2011, Journal of proteome research.

Alveolar derecruitment and collapse induration as crucial mechanisms in lung injury and fibrosis.

Bradford J. Smith, J. Bates, C. Ruppert, 2015, American journal of respiratory cell and molecular biology.

Comparative proteome analysis of lung tissue from patients with idiopathic pulmonary fibrosis (IPF), non-specific interstitial pneumonia (NSIP) and organ donors.

B. Ghanim, C. Ruppert, W. Seeger, 2013, Journal of proteomics.

Mechanical ventilation-induced alterations of intracellular surfactant pool and blood–gas barrier in healthy and pre-injured lungs

Bradford J. Smith, C. Ruppert, L. Knudsen, 2020, Histochemistry and Cell Biology.

Surfactant replacement therapy reduces acute lung injury and collapse induration-related lung remodeling in the bleomycin model.

Matthias Ochs, Christian Mühlfeld, Lars Knudsen, 2017, American journal of physiology. Lung cellular and molecular physiology.

WNT/RYK signaling restricts goblet cell differentiation during lung development and repair

C. Ruppert, D. Stainier, A. Guenther, 2019, Proceedings of the National Academy of Sciences.

Recombinant surfactant protein C-based surfactant for patients with severe direct lung injury.

C. Ruppert, A. Günther, N. Dean, 2011, American journal of respiratory and critical care medicine.

An ELISA technique for quantification of surfactant apoprotein (SP)-C in bronchoalveolar lavage fluid.

C. Ruppert, W. Seeger, A. Günther, 1995, American journal of respiratory and critical care medicine.

Potential applications of flat-panel volumetric CT in morphologic and functional small animal imaging.

Wolfhard Semmler, Fabian Kiessling, Andreas Günther, 2005, Neoplasia.

Cancer cachexia alters intracellular surfactant metabolism but not total alveolar surface area

C. Ruppert, G. Krasteva, C. Mühlfeld, 2012, Histochemistry and Cell Biology.

Combined Pulmonary Fibrosis and Emphysema: When Scylla and Charybdis Ally

C. Ruppert, S. Karnati, D. Kosanovic, 2023, Cells.

Translational Research in Acute Lung Injury and Pulmonary Fibrosis Linking progression of fibrotic lung remodeling and ultrastructural alterations of alveolar epithelial type II cells in the amiodarone mouse model

C. Ruppert, A. Günther, M. Ochs, 2015 .

ADPGK‐AS1 long noncoding RNA switches macrophage metabolic and phenotypic state to promote lung cancer growth

C. Ruppert, S. Pullamsetti, R. Savai, 2023, The EMBO journal.

Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease

C. Ruppert, D. Stainier, M. Looso, 2018, Nature Communications.

Induction of tissue factor by urokinase in lung epithelial cells and in the lungs.

C. Ruppert, E. Abraham, S. Shetty, 2010, American journal of respiratory and critical care medicine.

COAGULATION CASCADE | Antithrombin III

C. Ruppert, A. Günther, 2006 .

Externalized histones fuel pulmonary fibrosis via a platelet-macrophage circuit of TGFβ1 and IL-27

C. Ruppert, I. Prinz, Arjun Sharma, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Epithelial stress and apoptosis underlie Hermansky-Pudlak syndrome-associated interstitial pneumonia.

C. Ruppert, W. Seeger, S. Bellusci, 2010, American journal of respiratory and critical care medicine.

Patients with ARDS show improvement, but not normalization of alveolar surface activity upon surfactant treatment: putative role of neutral lipids

C. Ruppert, T. Colaris, M. Wygrecka, 2007 .

Linking progression of fibrotic lung remodeling and ultrastructural alterations of alveolar epithelial type II cells in the amiodarone mouse model.

C. Ruppert, E. Lopez-Rodriguez, P. Mahavadi, 2015, American journal of physiology. Lung cellular and molecular physiology.

GLI1+ Cells Contribute to Vascular Remodeling in Pulmonary Hypertension

C. Ruppert, S. Bellusci, M. Looso, 2024, Circulation research.

Cyclin D-CDK4 Disulfide Bond Attenuates Pulmonary Vascular Cell Proliferation

C. Ruppert, S. Krasemann, O. Rudyk, 2023, Circulation research.

Pre-clinical proof-of-concept of anti-fibrotic activity of caveolin-1 scaffolding domain peptide LTI-03 in ex vivo precision cut lung slices from patients with Idiopathic Pulmonary Fibrosis

C. Ruppert, P. Mahavadi, Andreas Guenther, 2024, bioRxiv.