Y. Okada

Y. Okada, S. Sakai, R. Ohtsuki, 2018, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

Vascular tissue fragility assessed by a new double stain method.

Y. Okada, Masahiko Zuka, N. Takekoshi, 2003 .

Vascular Tissue Fragility Assessed by a New Double Stain Method

Y. Okada, Masahiko Zuka, N. Takekoshi, 2003, Applied immunohistochemistry & molecular morphology : AIMM.

Expression of membrane-type 1 matrix metalloproteinase and activation of progelatinase A in human osteoarthritic cartilage.

Y. Okada, H. Sato, M. Seiki, 1997, The American journal of pathology.

Expression of matrix metalloproteinase 7 (matrilysin) in human osteoarthritic cartilage.

Y. Okada, K. Imai, T. Matsumoto, 1998, Laboratory investigation; a journal of technical methods and pathology.

Expression and Tissue Localization of Membrane-Types 1, 2, and 3 Matrix Metalloproteinases in Rheumatoid Synovium

Y. Okada, Hiroshi Sato, M. Seiki, 2000, Laboratory Investigation.

Expression of membrane-type matrix metalloproteinase 1 (MT1-MMP) in tumor cells enhances pulmonary metastasis in an experimental metastasis assay.

Y. Okada, A. Shinagawa, H. Sato, 1996, Cancer research.

Activation of the precursor of gelatinase A/72 kda type IV collagenase/MMP‐2 in lung carcinomas correlates with the expression of membrane‐type matrix metalloproteinase (MT‐MMP) and with lymph node metastasis

Y. Okada, Hiroshi Sato, M. Seiki, 1995, International journal of cancer.

Connective tissue growth factor is a substrate of ADAM28.

Y. Okada, M. Shimoda, S. Mochizuki, 2010, Biochemical and biophysical research communications.

Immunolocalization of complement C1s and matrix metalloproteinase 9 (92kDa gelatinase/type IV collagenase) in the primary ossification center of the human femur

Y. Okada, H. Moriya, H. Ohtsu, 1994, Cell and Tissue Research.

Complement Cls, a classical enzyme with novel functions at the endochondral ossification center: immunohistochemical staining of activated Cls with a neoantigen-specific antibody

Y. Okada, H. Moriya, S. Imajoh-ohmi, 1997, Cell and Tissue Research.

Immunologicalization of complement C1s and matrix metalloproteinase 9 (92kDa gelatinase/type IV collagenase) in the primary ossification center of the human femur

Y. Okada, H. Moriya, H. Ohtsu, 1994, Cell and Tissue Research.

Neutrophil-Derived Matrix Metalloproteinase 9 Triggers Acute Aortic Dissection

Y. Okada, S. Weiss, H. Itoh, 2012, Circulation.

A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 8 (neutrophil collagenase) using monoclonal antibodies.

Y. Okada, K. Iwata, N. Fujimoto, 1993, Clinica chimica acta; international journal of clinical chemistry.

Thyroid transcription factor-1 influences the early phase of compensatory lung growth in adult mice.

Y. Okada, Eiji Ikeda, Y. Izumi, 2010, American journal of respiratory and critical care medicine.

Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization Is Up-Regulated and Involved in Hyaluronan Degradation in Human Osteoarthritic Cartilage.

Y. Okada, Y. Toyama, Masaya Nakamura, 2018, The American journal of pathology.

Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human oral squamous cell carcinomas: Implications for lymph node metastasis

Y. Okada, Hiroshi Sato, M. Seiki, 2004, Clinical & Experimental Metastasis.

Prevalence of Patent Foramen Ovale in the Japanese Population- Autopsy Study.

Y. Okada, K. Fukuda, T. Dembo, 2015, Circulation journal : official journal of the Japanese Circulation Society.

Accelerated cartilage resorption by chondroclasts during bone fracture healing in osteoprotegerin-deficient mice.

Y. Okada, Y. Toyama, M. Matsumoto, 2009, Endocrinology.

Contribution of matrilysin (MMP-7) to the metastatic pathway of human colorectal cancers

Y. Okada, H. Yamamoto, Hiroyuki Yamamoto, 1999, Gut.

High-mobility group box 1 protein blockade suppresses development of abdominal aortic aneurysm.

Y. Okada, S. Yamada, S. Ogawa, 2012, Journal of cardiology.

Targeted deletion or pharmacological inhibition of MMP-2 prevents cardiac rupture after myocardial infarction in mice.

Y. Okada, S. Ogawa, S. Mochizuki, 2005, The Journal of clinical investigation.

Y. Okada, E. Kunieda, K. Fukuda, 2007, The Keio journal of medicine.

Overexpression and knock-down studies highlight that a disintegrin and metalloproteinase 28 controls proliferation and migration in human prostate cancer

Y. Okada, P. Leedman, S. Boulos, 2016, Medicine.

Soluble vascular adhesion protein-1 accumulates in proliferative diabetic retinopathy.

Y. Okada, S. Kase, A. Kanda, 2012, Investigative ophthalmology & visual science.

Binding of ADAM28 to P-selectin Glycoprotein Ligand-1 Enhances P-selectin-mediated Leukocyte Adhesion to Endothelial Cells*

Y. Okada, M. Shimoda, S. Ishida, 2007, Journal of Biological Chemistry.

Cleavage of Insulin-like Growth Factor Binding Protein-3 Implications for Carcinoma Cell Proliferation through ADAM 28 Is Overexpressed in Human Breast Carcinomas : Updated

T. Shiomi, Y. Okada, T. Kodama, 2006 .

ADAM28 is overexpressed in human non‐small cell lung carcinomas and correlates with cell proliferation and lymph node metastasis

T. Shiomi, Y. Okada, T. Kodama, 2006, International journal of cancer.

ADAM 28 Is Overexpressed in Human Breast Carcinomas : Implications for Carcinoma Cell Proliferation through Cleavage of Insulin-like Growth Factor Binding Protein-3

T. Shiomi, Y. Okada, T. Kodama, 2006 .

Tumorigenesis and Neoplastic Progression ADAM12 Is Selectively Overexpressed in Human Glioblastomas and Is Associated with Glioblastoma Cell Proliferation and Shedding of Heparin-Binding Epidermal Growth Factor

T. Shiomi, Y. Okada, T. Kodama, 2004 .

Degeneration of mesencephalic dopaminergic neurons in klotho mouse related to vitamin D exposure

Y. Okada, A. Kosakai, D. Ito, 2011, Brain Research.

Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas.

Y. Okada, H. Sato, M. Seiki, 1997, Cancer research.

ADAM28 is elevated in humans with the metabolic syndrome and is a novel sheddase of human tumour necrosis factor‐α

J. Blangero, Y. Okada, J. Curran, 2012, Immunology and cell biology.

Tumor necrosis factor-α converting enzyme inactivation ameliorates high-fat diet-induced insulin resistance and altered energy homeostasis.

K. Horiuchi, Y. Okada, S. Ogawa, 2011, Circulation journal : official journal of the Japanese Circulation Society.

Superoxide dismutase expression attenuates cigarette smoke- or elastase-generated emphysema in mice.

M. Inouye, Y. Okada, J. D’Armiento, 2006, American journal of respiratory and critical care medicine.

ADAM28 is a serological and histochemical marker for non‐small‐cell lung cancers

Y. Okada, H. Horinouchi, M. Shimoda, 2010, International journal of cancer.

A Case of Disseminated Cryptococcal Infection and Concurrent Lung Tuberculosis in a Patient under Steroid Therapy for Interstitial Pneumonia

T. Betsuyaku, Y. Okada, Yusuke Suzuki, 2015, Case reports in pulmonology.

Expression of TNF‐α and CD44 is implicated in poor prognosis, cancer cell invasion, metastasis and resistance to the sunitinib treatment in clear cell renal cell carcinomas

Y. Okada, H. Saya, M. Oya, 2015, International journal of cancer.

Adventitial CXCL1/G-CSF Expression in Response to Acute Aortic Dissection Triggers Local Neutrophil Recruitment and Activation Leading to Aortic Rupture

Y. Okada, K. Fukuda, M. Shimoda, 2015, Circulation research.

Fibulin‐7 is overexpressed in glioblastomas and modulates glioblastoma neovascularization through interaction with angiopoietin‐1

Y. Okada, H. Arai, M. Nakada, 2019, International journal of cancer.

Primary invasive micropapillary carcinoma of the stomach

Y. Okada, T. Omori, M. Shimoda, 2008, Pathology international.

Src plays a key role in ADAM28 expression in v-src-transformed epithelial cells and human carcinoma cells.

Y. Okada, Hiroshi Sato, O. Hino, 2013, The American journal of pathology.

High efficacy of third generation EGFR inhibitor AZD9291 in a leptomeningeal carcinomatosis model with EGFR-mutant lung cancer cells

Y. Okada, S. Yano, M. Nakada, 2015, Oncotarget.

Collagenase expression in transgenic mouse skin causes hyperkeratosis and acanthosis and increases susceptibility to tumorigenesis

Y. Okada, J. D’Armiento, K. Chada, 1995, Molecular and cellular biology.

Hyaluronan Degradation by Cemip Regulates Host Defense against Staphylococcus aureus Skin Infection

Y. Okada, M. Shimoda, R. Gallo, 2020, Cell reports.

Relaxed specificity of matrix metalloproteinases (MMPS) and TIMP insensitivity of tumor necrosis factor-alpha (TNF-alpha) production suggest the major TNF-alpha converting enzyme is not an MMP.

Y. Okada, B. Castner, M. Gerhart, 1996, Biochemical and biophysical research communications.

Expression of vascular endothelial growth factor isoforms and their receptors Flt‐1, KDR, and neuropilin‐1 in synovial tissues of rheumatoid arthritis

Y. Okada, Y. Hosoda, M. Ikeda, 2000, The Journal of pathology.

Expression of immunoreactive matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in human normal livers and primary liver tumors

Y. Okada, T. Terada, Y. Nakanuma, 1996, Hepatology.

Unusual hemangioendothelioma of the liver with epithelioid morphology associated with marked eosinophilia: Autopsy case

Y. Okada, Y. Ikeda, M. Sakamoto, 2006, Pathology international.

Coexpression of heparanase, basic fibroblast growth factor and vascular endothelial growth factor in human esophageal carcinomas

Y. Okada, T. Nemoto, K. Ohashi, 2004, Pathology international.

Prediction of response to remission induction therapy by gene expression profiling of peripheral blood in Japanese patients with microscopic polyangiitis

Y. Okada, A. Ishizu, K. Yamagata, 2017, Arthritis Research & Therapy.

Resveratrol prevents the development of abdominal aortic aneurysm through attenuation of inflammation, oxidative stress, and neovascularization.

Y. Okada, S. Ogawa, K. Fukuda, 2011, Atherosclerosis.

EMPHYSEMATOUS CHANGES ARE CAUSED BY DEGRADATION OF TYPE III COLLAGEN IN TRANSGENIC MICE EXPRESSING MMP-1

T. Shiomi, Y. Okada, J. D’Armiento, 2003, Experimental lung research.

Role of Crk-associated substrate lymphocyte type in the pathophysiology of rheumatoid arthritis in tax transgenic mice and in humans.

Y. Okada, S. Iwata, C. Morimoto, 2003, Arthritis and rheumatism.

Expression of ADAMTS-4 (aggrecanase-1) and Possible Involvement in Regression of Lumbar Disc Herniation

Y. Okada, Y. Ueda, S. Katsuda, 2006, Spine.

Expression of emmprin (CD147), a cell surface inducer of matrix metalloproteinases, in normal human brain and gliomas

Y. Okada, B. Toole, K. Nabeshima, 2000, International journal of cancer.

Glioma cell extracellular matrix metalloproteinase inducer (EMMPRIN) (CD147) stimulates production of membrane-type matrix metalloproteinases and activated gelatinase A in co-cultures with brain-derived fibroblasts.

Y. Okada, B. Toole, K. Nabeshima, 2000, Cancer letters.

Mechanisms of Angiogenic Suppression in Uteri Exposed to Diethylstilbestrol Neonatally in the Mouse1

Y. Okada, A. Kudo, S. Yamashita, 2013, Biology of reproduction.

Comparison of severity classification in Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis in a nationwide, prospective, inception cohort study

Y. Okada, Y. Takasaki, Y. Yuzawa, 2016, Modern rheumatology.

Impaired bone fracture healing in matrix metalloproteinase-13 deficient mice.

Kozo Nakamura, Y. Okada, J. D’Armiento, 2007, Biochemical and biophysical research communications.

Bone growth retardation in mouse embryos expressing human collagenase 1.

Y. Okada, J. D’Armiento, S. Dalal, 2007, American journal of physiology. Cell physiology.

Tetraspanin CD151 is expressed in osteoarthritic cartilage and is involved in pericellular activation of pro-matrix metalloproteinase 7 in osteoarthritic chondrocytes.

T. Shiomi, Y. Okada, Y. Toyama, 2006, Arthritis and rheumatism.

Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis

Y. Okada, K. Fujikawa, Harumoto Yamada, 2000, Annals of the rheumatic diseases.

Application of Heat-induced Antigen Retrieval to Aldehyde-fixed Fresh Frozen Sections

Y. Okada, S. Yamashita, 2005, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Parkinson's disease therapy with Istradefylline and blood biomarkers of epigenetics

Y. Okada, S. Mochizuki, N. Kanzato, 2020 .

Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human papillary thyroid carcinomas.

M. Noguchi, Y. Okada, H. Sato, 1999, Cancer research.

Marked increase of matrix metalloproteinase 9 in cerebrospinal fluid of patients with fungal or tuberculous meningoencephalitis

Y. Okada, E. Matsuura, T. Hashiguchi, 2000, Journal of the Neurological Sciences.

Activation of the aryl hydrocarbon receptor pathway enhances cancer cell invasion by upregulating the MMP expression and is associated with poor prognosis in upper urinary tract urothelial cancer.

Y. Okada, K. Nakagawa, E. Kikuchi, 2010, Carcinogenesis.

Expression of membrane-type matrix metalloproteinase in human gastric carcinomas.

Y. Okada, M. Mai, H. Sato, 1995, Cancer research.

Deficiency of matrix metalloproteinase-13 increases inflammation after acute lung injury

T. Shiomi, Y. Okada, J. D’Armiento, 2010, Experimental lung research.

Purification of matrix metalloproteinases by column chromatography

Y. Okada, K. Imai, 2008, Nature Protocols.

Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases

Y. Okada, Hiroshi Sato, Takuma Sasaki, 2003, Oncogene.

The Citrus Flavonoid, Nobiletin, Inhibits Peritoneal Dissemination of Human Gastric Carcinoma in SCID Mice

Y. Okada, T. Kubota, Y. Otani, 2001, Japanese journal of cancer research : Gann.

Epithelial Cell-Derived a Disintegrin and Metalloproteinase-17 Confers Resistance to Colonic Inflammation Through EGFR Activation

K. Horiuchi, Y. Okada, T. Tsukamoto, 2016, EBioMedicine.

Deficiency of inducible nitric oxide synthase exacerbates hepatic fibrosis in mice fed high-fat diet.

Y. Okada, T. Mine, Y. Ogushi, 2004, Biochemical and biophysical research communications.

Differential expression of WNTs and FRPs in the synovium of rheumatoid arthritis and osteoarthritis.

Y. Okada, J. D’Armiento, H. Matsumoto, 2006, Biochemical and biophysical research communications.

Transformation of epithelial Madin-Darby canine kidney cells with p60(v-src) induces expression of membrane-type 1 matrix metalloproteinase and invasiveness.

Y. Okada, H. Sato, Hiroshi Sato, 1998, Cancer research.

Heart failure causes cholinergic transdifferentiation of cardiac sympathetic nerves via gp130-signaling cytokines in rodents.

H. Okano, Y. Okada, K. Kimura, 2010, The Journal of clinical investigation.

Dual functions of cell-autonomous and non-cell-autonomous ADAM10 activity in granulopoiesis.

K. Horiuchi, Y. Okada, D. Link, 2011, Blood.

A one-step sandwich enzyme immunoassay for inactive precursor and complexed forms of human matrix metalloproteinase 9 (92 kDa gelatinase/type IV collagenase, gelatinase B) using monoclonal antibodies.

Y. Okada, K. Iwata, N. Fujimoto, 1994, Clinica chimica acta; international journal of clinical chemistry.

Synovial procollagenase activation by human mast cell tryptase dependence upon matrix metalloproteinase 3 activation.

K. Suzuki, Y. Okada, Ko Suzuki, 1989, The Journal of clinical investigation.

Enhanced susceptibility to lipopolysaccharide-induced arthritis and endotoxin shock in interleukin-32 alpha transgenic mice through induction of tumor necrosis factor alpha

K. Horiuchi, Y. Okada, Y. Toyama, 2012, Arthritis Research & Therapy.

A Novel Mouse Model of Soft-Tissue Infection Using Bioluminescence Imaging Allows Noninvasive, Real-Time Monitoring of Bacterial Growth

Y. Okada, Y. Toyama, S. Koyasu, 2014, PloS one.

RGD-CAP ((beta)ig-h3) is expressed in precartilage condensation and in prehypertrophic chondrocytes during cartilage development.

Y. Okada, Y. Kato, K. Tanne, 2002, Biochimica et biophysica acta.

Y. Okada, Y. Ueda, T. Yoshikawa, 2008, Pathology international.

Future Utility of Animal Models for COPD

Y. Okada, K. Chada, S. Dalal, 2015 .

A one-step sandwich enzyme immunoassay using monoclonal antibodies for detection of human neutrophil elastase

Y. Okada, S. Yoshida, K. Iwata, 1995 .

A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 1 (interstitial collagenase) using monoclonal antibodies.

Y. Okada, K. Iwata, N. Fujimoto, 1993, Clinica chimica acta; international journal of clinical chemistry.

Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization Controls Endochondral Ossification through Hyaluronan Metabolism.

K. Horiuchi, Y. Okada, Y. Kanai, 2017, The American journal of pathology.

MT-MMP, the cell surface activator of proMMP-2 (pro-gelatinase A), is expressed with its substrate in mouse tissue during embryogenesis.

Y. Okada, H. Sato, Hiroshi Sato, 1996, Journal of cell science.

A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 2 (72-kDa gelatinase/type IV collagenase) using monoclonal antibodies.

Y. Okada, K. Iwata, N. Fujimoto, 1993, Clinica chimica acta; international journal of clinical chemistry.

A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 3 (stromelysin-1) using monoclonal antibodies.

Y. Okada, S. Yoshida, K. Iwata, 1992, Clinica chimica acta; international journal of clinical chemistry.

Induction and stimulation of 92-kDa gelatinase/type IV collagenase production in osteosarcoma and fibrosarcoma cell lines by tumor necrosis factor alpha.

Y. Okada, K. Tomita, H. Sato, 1990, Biochemical and biophysical research communications.

Cutting Edge: TNF-α-Converting Enzyme (TACE/ADAM17) Inactivation in Mouse Myeloid Cells Prevents Lethality from Endotoxin Shock1

K. Horiuchi, C. Blobel, Y. Okada, 2007, The Journal of Immunology.

Importance of tumor necrosis factor-alpha cleavage process in post-transplantation lung injury in rats.

Y. Okada, I. Maruyama, A. Ishizaka, 2004, American journal of respiratory and critical care medicine.

Shedding of Membrane Type 1 Matrix Metalloproteinase in a Human Breast Carcinoma Cell Line

Y. Okada, Hiroshi Sato, M. Seiki, 1999, Japanese journal of cancer research : Gann.

A One‐Step Sandwich Enzyme Immunoassay for Human Matrix Metalloproteinase 9 Using Monoclonal Antibodies

Y. Okada, K. Iwata, N. Fujimoto, 1994, Annals of the New York Academy of Sciences.

CCN1 (Cyr61) Is Overexpressed in Human Osteoarthritic Cartilage and Inhibits ADAMTS‐4 (Aggrecanase 1) Activity

Y. Okada, Y. Toyama, Yukie Tanaka, 2015, Arthritis & rheumatology.

Calcium pentosan polysulfate directly inhibits enzymatic activity of ADAMTS4 (aggrecanase‐1) in osteoarthritic chondrocytes

Y. Okada, S. Mochizuki, M. Chijiiwa, 2008, FEBS letters.

Expression of ADAMTS4 (aggrecanase‐1) in human osteoarthritic cartilage

T. Shiomi, Y. Okada, K. Fujikawa, 2007, Pathology international.

ADAMTS4 (Aggrecanase-1) Interaction with the C-terminal Domain of Fibronectin Inhibits Proteolysis of Aggrecan*

Y. Okada, M. Shimoda, G. Hashimoto, 2004, Journal of Biological Chemistry.

Matrix metalloproteinases 1, 2, and 3 from rheumatoid synovial cells are sufficient to destroy joints.

Y. Okada, E. D. Harris, H. Nagase, 1987, The Journal of rheumatology.

Increased matrix metalloproteinases as possible cause of osseoarticular tissue destruction in long-term haemodialysis and β2-microglobulin amyloidosis

Y. Okada, K. Ohashi, Y. Ogura, 1996, Virchows Archiv.

Research communicationA one-step sandwich enzyme immunoassay for human matrix metalloproteinase 8 (neutrophil collagenase) using monoclonal antibodies

Y. Okada, K. Iwata, N. Fujimoto, 1996 .

Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema

Y. Okada, J. D’Armiento, K. Chada, 1992, Cell.

Determination of tissue inhibitor of metalloproteinases-2 (TIMP-2) in experimental animals using monoclonal antibodies against TIMP-2-specific oligopeptides.

Y. Okada, K. Iwata, N. Fujimoto, 1995, Journal of immunological methods.

Tissue Inhibitor of Metalloproteinase 1 Is a Negative Regulator of the Metastatic Ability of a Human Gastric Cancer Cell Line, KKLS, in the Chick Embryo1

Y. Okada, Hiroshi Sato, Takuma Sasaki, 2006 .

Expression of Snail and Slug in renal cell carcinoma: E-cadherin repressor Snail is associated with cancer invasion and prognosis

Y. Okada, M. Oya, R. Mizuno, 2011, Laboratory Investigation.

Degradation of T-kininogen by cathepsin D and matrix metalloproteinases.

Y. Okada, J. Nishihira, J. Kishi, 1996, Immunopharmacology.

Prognostic Role of KiSS-1 and Possibility of Therapeutic Modality of Metastin, the Final Peptide of the KiSS-1 Gene, in Urothelial Carcinoma

Y. Okada, E. Suzuki, E. Kikuchi, 2012, Molecular Cancer Therapeutics.

Matrix Metalloproteinase Inhibitor, Marimastat, Decreases Peritoneal Spread of Gastric Carcinoma in Nude Mice

Y. Okada, T. Kubota, Y. Otani, 2002, Japanese journal of cancer research : Gann.

Recent advances in renal cell carcinoma from a pathological point of view

Y. Okada, M. Oya, Y. Nagashima, 2016, Pathology international.

Caudal Regression and Tracheoesophageal Malformation Induced by Adriamycin: A Novel Chick Model of VATER Association

Y. Okada, K. Kosaki, Takao Takahashi, 2009, Pediatric Research.

Brain-Specific Expression of Vascular Endothelial Growth Factor 146 Correlates with the Blood-Brain Barrier Induction in Quail Embryos

Y. Okada, T. Kodama, K. Takubo, 2008, Developmental Neuroscience.

Matrix Degradation in Osteoclastic Bone Resorption Under Pathological Conditions

Y. Okada, 1999 .

Absence of Gelatinase (MMP-9) or Collagenase (MMP-13) Attenuates Adriamycin-Induced Albuminuria and Glomerulosclerosis

Y. Okada, J. D’Armiento, H. Sasamura, 2010, Nephron Experimental Nephrology.

Production of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Human Breast Carcinomas

Y. Okada, H. Iwata, H. Iwase, 1996, Japanese journal of cancer research : Gann.

Stimulation of gelatinase B and tissue inhibitors of metalloproteinase (TIMP) production in co‐culture of human osteosarcoma cells and human fibroblasts: Gelatinase‐B production was stimulated via up‐regulation of fibroblast growth factor (FGF) receptor

Y. Okada, K. Nabeshima, Y. Okada, 1996, International journal of cancer.

Tissue Inhibitor of Metalloproteinase 1 Is a Negative Regulator of the Metastatic Ability of a Human Gastric Cancer Cell Line , KKLS , in the Chick Embryo 1

Y. Okada, Hiroshi Sato, Takuma Sasaki, 1993 .

The precursor of a metalloendopeptidase from human rheumatoid synovial fibroblasts. Purification and mechanisms of activation by endopeptidases and 4-aminophenylmercuric acetate.

Y. Okada, E. D. Harris, H. Nagase, 1988, The Biochemical journal.

ADAM28 is expressed by epithelial cells in human normal tissues and protects from C1q‐induced cell death

Y. Okada, M. Shimoda, Y. Kitagawa, 2016, The FEBS journal.

VIP36 Protein Is a Target of Ectodomain Shedding and Regulates Phagocytosis in Macrophage Raw 264.7 Cells*

Y. Okada, S. Hattori, S. Koyasu, 2011, The Journal of Biological Chemistry.

Constitutive and Induced CD44 Shedding by ADAM-Like Proteases and Membrane-Type 1 Matrix Metalloproteinase

Y. Okada, M. Seiki, N. Suenaga, 2004, Cancer Research.

Role of vascular endothelial growth factor-A in development of abdominal aortic aneurysm.

Y. Okada, S. Ogawa, K. Fukuda, 2011, Cardiovascular research.

Serum levels of matrix metalloproteinase 3 (stromelysin 1) for monitoring synovitis in rheumatoid arthritis.

Y. Okada, Kazuhiko Inoue, Tokuhiro Kimura, 2007, Archives of pathology & laboratory medicine.

Differences between scirrhous and non-scirrhous human gastric carcinomas from the aspect of proMMP-2 activation regulated by TIMP-3

Y. Okada, T. Kubota, Y. Otani, 2004, Clinical & Experimental Metastasis.

Increased expression of type VI collagen genes in drug‐induced gingival enlargement

Y. Okada, Y. Oda, Y. Okada, 1993, FEBS letters.

Local Tenomodulin Absence, Angiogenesis, and Matrix Metalloproteinase Activation Are Associated With the Rupture of the Chordae Tendineae Cordis

Y. Okada, D. Docheva, K. Fukuda, 2008, Circulation.

Secretion of matrix metalloproteinase-2 (72 kD gelatinase/type IV collagenase = gelatinase A) by malignant human glioma cell lines: implications for the growth and cellular invasion of the extracellular matrix

Y. Okada, T. Kubota, N. Fujimoto, 1996, Journal of Neuro-Oncology.

TNF-alpha-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock

K. Horiuchi, C. Blobel, Y. Okada, 2007 .

Production and activation of matrix metalloproteinase-2 in proliferative diabetic retinopathy.

Y. Okada, K. Noda, S. Ishida, 2003, Investigative ophthalmology & visual science.

Ets-1 positively regulates expression of urokinase-type plasminogen activator (uPA) and invasiveness of astrocytic tumors.

Y. Okada, H. Sato, M. Nakada, 1999, Journal of neuropathology and experimental neurology.

Distribution and function of hyaluronan binding protein involved in hyaluronan depolymerization (HYBID, KIAA1199) in the mouse central nervous system

Y. Okada, H. Hara, M. Shimoda, 2017, Neuroscience.

The Metalloproteinase ADAM28 Promotes Metabolic Dysfunction in Mice

Y. Okada, V. Matthews, S. Mochizuki, 2017, International journal of molecular sciences.

HYBID (alias KIAA1199/CEMIP) and hyaluronan synthase coordinately regulate hyaluronan metabolism in histamine-stimulated skin fibroblasts

Y. Okada, S. Sakai, H. Yoshida, 2020, The Journal of Biological Chemistry.

High mobility group I-C protein in astrocytoma and glioblastoma.

Y. Okada, K. Chada, T. Date, 2004, Pathology, research and practice.

Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human urothelial carcinomas.

Y. Okada, H. Ito, H. Sato, 1998, The Journal of urology.

Stimulation of TIMP-1 and metalloproteinase production in co-cultures of human tumor cells and human fibroblasts.

Y. Okada, K. Nabeshima, Y. Okada, 1994, Cancer letters.

Tumor necrosis factor-α converting enzyme is a key mediator of abdominal aortic aneurysm development.

K. Horiuchi, Y. Okada, K. Fukuda, 2011 .

Characterization of a truncated recombinant form of human membrane type 3 matrix metalloproteinase.

Y. Okada, H. Sato, Hiroshi Sato, 1999, European journal of biochemistry.

Reduced Levels of MMP‐2 and TIMP‐1 in Dyssegmental Dysplasia

Y. Okada, K. Uchide, H. Ueno, 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

A one-step sandwich enzyme immunoassay for tissue inhibitor of metalloproteinases-2 using monoclonal antibodies.

Y. Okada, K. Iwata, N. Fujimoto, 1993, Clinica chimica acta; international journal of clinical chemistry.

Development of In Situ Zymography to Localize Active Matrix Metalloproteinase-7 (Matrilysin-1)

T. Shiomi, Y. Okada, G. Hashimoto, 2005, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Metalloproteinases in Human Invasive Breast Carcinomas

Y. Okada, Hiroshi Sato, M. Seiki, 2011 .

TWO-STEP SANDWICH ENZYME IMMUNOASSAY USING MONOCLONAL ANTIBODIES FOR DETECTION OF SOLUBLE AND MEMBRANE- ASSOCIATED HUMAN MEMBRANE TYPE 1-MATRIX METALLOPROTEINASE

T. Shiomi, Y. Okada, M. Seiki, 2002, Journal of immunoassay & immunochemistry.

Matrix metalloproteinases and tissue inhibitor of metalloproteinase-2 in fetal rabbit lung.

Y. Okada, Y. Fukuda, M. Ishizaki, 2000, American journal of physiology. Lung cellular and molecular physiology.

Cell surface binding and activation of gelatinase A induced by expression of membrane‐type‐1‐matrix metalloproteinase (MT1‐MMP)

Y. Okada, H. Sato, Hiroshi Sato, 1996, FEBS letters.

Susceptibility of tenascin to degradation by matrix metalloproteinases and serine proteinases

Y. Okada, M. Kusakabe, T. Sakakura, 1994, FEBS letters.

Reduced angiogenesis in peritoneal dissemination of gastric cancer through gelatinase inhibition

Y. Okada, T. Kubota, Y. Otani, 2003, Clinical & Experimental Metastasis.

Localization of matrix metalloproteinase 9 (92-kilodalton gelatinase/type IV collagenase = gelatinase B) in osteoclasts: implications for bone resorption.

Y. Okada, H. Sato, M. Seiki, 1995, Laboratory investigation; a journal of technical methods and pathology.

Predominant expression of OLIG2 over ID2 in oligodendroglial tumors

Y. Okada, T. Kawase, K. Nagashima, 2007, Virchows Archiv.

Heat-induced Antigen Retrieval in Conventionally Processed Epon-embedded Specimens

Y. Okada, S. Yamashita, 2014, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Synthetic emmprin peptides with chitobiose substitution stimulate MMP-2 production by fibroblasts

Y. Okada, B. Toole, K. Nabeshima, 2011, BMC Cancer.

Expression of Heparanase in Renal Cell Carcinomas: Implications for Tumor Invasion and Prognosis

Y. Okada, M. Oya, M. Nakajima, 2008, Clinical Cancer Research.

Tissue inhibitor of metalloproteinase 1 is a negative regulator of the metastatic ability of a human gastric cancer cell line, KKLS, in the chick embryo.

Y. Okada, H. Sato, M. Seiki, 1993, Cancer research.

Pericellular activation of proMMP-7 (promatrilysin-1) through interaction with CD151

T. Shiomi, Y. Okada, T. Ohtsuka, 2005, Laboratory Investigation.

Implication of cell migration inducing hyaluronidase 1 (CEMIP) in hyaluronan degradation by synovial fibroblasts in patients with knee osteoarthritis.

Y. Okada, K. Kaneko, H. Kaneko, 2020, The American journal of pathology.

Regulation of Hyaluronan (HA) Metabolism Mediated by HYBID (Hyaluronan-binding Protein Involved in HA Depolymerization, KIAA1199) and HA Synthases in Growth Factor-stimulated Fibroblasts*

Y. Okada, S. Sakai, S. Inoue, 2015, The Journal of Biological Chemistry.

Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in HTLV-I-associated myelopathy.

Y. Okada, N. Fujimoto, S. Izumo, 1998, Journal of neuropathology and experimental neurology.

Expression of matrix proteinases during human intrahepatic bile duct development. A possible role in biliary cell migration.

Y. Okada, T. Terada, Y. Nakanuma, 1995, The American journal of pathology.

Establishment of a standardized post-embedding method for immunoelectron microscopy by applying heat-induced antigen retrieval.

Y. Okada, S. Yamashita, O. Katsumata, 2009, Journal of electron microscopy.

Immunohistochemistry of MMPs and TIMPs.

Y. Okada, 2010, Methods in molecular biology.

Vascular and Tumor Biology P 5 . 1 ADAM 28 expression in oncogene-transformed cells and human carcinoma cells

C. López-Otín, Y. Okada, T. Salo, 2012 .

Detection of von Willebrand factor-cleaving protease (ADAMTS-13) in human platelets.

Y. Okada, M. Murata, Y. Ikeda, 2004, Biochemical and biophysical research communications.

Welcome to Yokosuka Science Festa

Hiroko, Y. Okada, Osahiko Tsuji, 2008 .

Delayed Propionibacterium acnes surgical site infections occur only in the presence of an implant

Y. Okada, Y. Toyama, S. Koyasu, 2016, Scientific Reports.

ADAM-12 (meltrin alpha) is involved in chondrocyte proliferation via cleavage of insulin-like growth factor binding protein 5 in osteoarthritic cartilage.

T. Shiomi, Y. Okada, Y. Iwamoto, 2008, Arthritis and rheumatism.

Matrix Metalloproteinases Cleave Connective Tissue Growth Factor and Reactivate Angiogenic Activity of Vascular Endothelial Growth Factor 165*

Takanori Aoki, Gakuji Hashimoto, Yutaka Fujii, 2002, The Journal of Biological Chemistry.

Increased gene expression of matrix metalloproteinase-3 (stromelysin) in skin fibroblasts from patients with severe recessive dystrophic epidermolysis bullosa.

Y. Okada, I. Hashimoto, L. Bruckner-Tuderman, 1991, Biochemical and biophysical research communications.

A novel hydroxyapatite film coated with ionic silver via inositol hexaphosphate chelation prevents implant-associated infection

Y. Okada, Y. Toyama, S. Koyasu, 2016, Scientific Reports.

An antibacterial coated polymer prevents biofilm formation and implant-associated infection

Y. Okada, Y. Toyama, S. Koyasu, 2021, Scientific Reports.

Establishment of a Real-Time, Quantitative, and Reproducible Mouse Model of Staphylococcus Osteomyelitis Using Bioluminescence Imaging

Y. Okada, Y. Toyama, S. Koyasu, 2011, Infection and Immunity.

Mechanisms of Heat-induced Antigen Retrieval: Does pH or Ionic Strength of the Solution Play a Role for Refolding Antigens?

Y. Okada, S. Yamashita, K. Emoto, 2005, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Mechanisms of Heat-induced Antigen Retrieval: Analyses In Vitro Employing SDS-PAGE and Immunohistochemistry

Y. Okada, S. Yamashita, 2005 .

Mechanisms of heat-induced antigen retrieval: analyses in vitro employing SDS-PAGE and immunohistochemistry.

Y. Okada, S. Yamashita, 2005, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Stromal metalloproteinases: Crucial contributors to the tumor microenvironment

Y. Okada, Y. Kanai, M. Shimoda, 2020, Pathology international.

Hyperoxia-induced emphysematous changes in subacute phase of endotoxin-induced lung injury in rats.

T. Shiomi, Y. Okada, Akira Ohashi, 2004, American journal of physiology. Lung cellular and molecular physiology.

Membrane Type 1 Matrix Metalloproteinase Digests Interstitial Collagens and Other Extracellular Matrix Macromolecules*

Y. Okada, Hiroshi Sato, M. Seiki, 1997, The Journal of Biological Chemistry.

Y. Okada, Y. Toyama, K. Chiba, 2007, Spine.

The role of matrix metalloproteinases in glioma invasion.

Y. Okada, M. Nakada, J. Yamashita, 2003, Frontiers in bioscience : a journal and virtual library.

Misexpression of full-length HMGA2 induces benign mesenchymal tumors in mice.

Y. Okada, K. Chada, M. Zaidi, 2006, Cancer research.

Expression Profiles and Clinical Correlations of Degradome Components in the Tumor Microenvironment of Head and Neck Squamous Cell Carcinoma

Y. Okada, R. Ala-aho, V. Kähäri, 2010, Clinical Cancer Research.

Periostin derived from cancer-associated fibroblasts promotes esophageal squamous cell carcinoma progression via ADAM17 activation.

K. Horiuchi, Y. Okada, H. Tsujimoto, 2023, Biochimica et biophysica acta. Molecular basis of disease.

HMGA2 is a driver of tumor metastasis.

Y. Okada, J. D’Armiento, K. Chada, 2013, Cancer research.

Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer

Y. Okada, Y. Onodera, M. Oya, 2016, Nature Communications.

SAF‐3, a novel splice variant of the SAF‐1/MAZ/Pur‐1 family, is expressed during inflammation

Y. Okada, A. Shakya, B. Ray, 2009, The FEBS journal.

Roles of membrane type 1 matrix metalloproteinase and tissue inhibitor of metalloproteinases 2 in invasion and dissemination of human malignant glioma.

Y. Okada, H. Sato, M. Nakada, 2001, Journal of neurosurgery.

Semaphorin 3A is expressed in human osteoarthritic cartilage and antagonizes vascular endothelial growth factor 165-promoted chondrocyte migration: an implication for chondrocyte cloning.

Y. Okada, Y. Toyama, Y. Suda, 2011, Arthritis and rheumatism.

Hypoxia disrupts the barrier function of neural blood vessels through changes in the expression of claudin-5 in endothelial cells.

Y. Okada, K. Tsubota, K. Takubo, 2007, The American journal of pathology.

8 – Proteinases and Matrix Degradation

Y. Okada, 2013 .

Matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs in non‐neoplastic diseases

T. Shiomi, Y. Okada, J. D’Armiento, 2010, Pathology international.

RECK is up-regulated and involved in chondrocyte cloning in human osteoarthritic cartilage.

Y. Okada, Y. Toyama, A. Okada, 2010, The American journal of pathology.

Regulatory Role of Dendritic Cells in Postinfarction Healing and Left Ventricular Remodeling

Y. Okada, S. Ogawa, K. Fukuda, 2012, Circulation.

Hypoxia-Inducible Factor Regulates Survival of Antigen Receptor-Driven T Cells 1

Y. Okada, Hiroshi Nakamura, L. Poellinger, 2003, The Journal of Immunology.

A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization.

Y. Okada, E. D. Harris, H. Nagase, 1986, The Journal of biological chemistry.

Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state

Y. Okada, J. Wrana, T. Kislinger, 2014, Nature Cell Biology.

Tumor cell-matrix interaction: pericellular matrix degradation and metastasis.

Y. Okada, 2000, Verhandlungen der Deutschen Gesellschaft fur Pathologie.

Malignant transformation of sialadenoma papilliferum of the palate: a case report

Y. Okada, S. Morinaga, M. Shimoda, 2004, Virchows Archiv.

MALT1 Inhibition of Oral Carcinoma Cell Invasion and ERK/MAPK Activation

Y. Okada, H. Sudo, K. Imai, 2016, Journal of dental research.

Tokuda Akihiro Tomida Shinya Toyokuni Hitoshi Tsuda Shoichiro Tsugane Tatsuhiko Tsunoda Heiichiro Udono Koji Ueda Yoshimasa Uehara Hiroo Ueno Kazuo Umezawa Toshikazu Ushijima Toshihiko Wakabayashi Kenji Wakai Tetsuro Watabe

H. Aburatani, S. Hirota, Y. Kaneda, 2016 .

Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents.

Y. Okada, S. Ogawa, K. Fukuda, 2010, The Journal of clinical investigation.

Coexpression of VEGF receptors VEGF-R2 and neuropilin-1 in proliferative diabetic retinopathy.

Y. Okada, S. Kawashima, S. Ishida, 2000, Investigative ophthalmology & visual science.

Acquired platinum resistance involves epithelial to mesenchymal transition through ubiquitin ligase FBXO32 dysregulation.

Eiji Kikuchi, Per Uhlén, Naoya Niwa, 2016, JCI insight.

Expression and Function of a Disintegrin and Metalloproteinases in Cancer-Associated Fibroblasts of Colorectal Cancer

H. Ueno, Y. Okada, Y. Kajiwara, 2019, Digestion.

Regulation of monocyte chemoattractant protein-1 through angiotensin II type 1 receptor in prostate cancer.

Y. Okada, E. Kikuchi, A. Miyajima, 2012, The American journal of pathology.

MMP-13 plays a role in keratinocyte migration, angiogenesis, and contraction in mouse skin wound healing.

T. Nakajima, Y. Okada, J. D’Armiento, 2009, The American journal of pathology.

Physiological Environment Induces Quick Response – Slow Exhaustion Reactions

Christoph Flamm, Noriko Hiroi, Akira Funahashi, 2011, Front. Physio..

MT1-MMP and MMP-7 in invasion and metastasis of human cancers

T. Shiomi, Y. Okada, Yasunori Okada, 2003, Cancer and Metastasis Reviews.

Hypoxia induces the expression of membrane-type 1 matrix metalloproteinase in retinal glial cells.

Y. Okada, K. Tsubota, K. Noda, 2005, Investigative ophthalmology & visual science.

Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF‐induced angiogenesis

T. Shiomi, Y. Okada, S. Takata, 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

MET Copy Number Gain Is Associated with Gefitinib Resistance in Leptomeningeal Carcinomatosis of EGFR-mutant Lung Cancer

Y. Okada, Wei Wang, S. Yano, 2017, Molecular Cancer Therapeutics.

The prognostic significance of vasohibin-1 expression in patients with prostate cancer

Y. Okada, K. Nakagawa, H. Nagata, 2013, British Journal of Cancer.

Degradation of vitronectin by matrix metalloproteinases‐1, ‐2, ‐3, ‐7 and ‐9

H Shikata, Y. Okada, Y Okada, 1995, FEBS letters.

Membrane-type matrix metalloproteinase 1 is a gelatinolytic enzyme and is secreted in a complex with tissue inhibitor of metalloproteinases 2.

Y. Okada, H. Sato, Hiroshi Sato, 1996, Cancer research.

TIMP-2 Promotes Activation of Progelatinase A by Membrane-type 1 Matrix Metalloproteinase Immobilized on Agarose Beads*

Y. Okada, Hiroshi Sato, M. Seiki, 1998, The Journal of Biological Chemistry.

Molecular and Cellular Pathobiology HMGA 2 Is a Driver of Tumor Metastasis

Y. Okada, J. D’Armiento, K. Chada, 2013 .

Systemic Overexpression of TNFα-converting Enzyme Does Not Lead to Enhanced Shedding Activity In Vivo

K. Horiuchi, Y. Okada, Y. Toyama, 2013, PloS one.

Conditional Inactivation of TNFα-Converting Enzyme in Chondrocytes Results in an Elongated Growth Plate and Shorter Long Bones

K. Horiuchi, Y. Okada, D. Threadgill, 2013, PloS one.

Increased Granulopoiesis via Dysregulation Promoter Leads to Osteoporosis and Conditional Inactivation of TACE by a Sox9

K. Horiuchi, Y. Okada, Takashi Nakamura, 2013 .

Of Il-17 and G-csf Increased Granulopoiesis via Dysregulation Promoter Leads to Osteoporosis and Sox9 Conditional Inactivation of Tace by a Blobel and Yoshiaki Toyama

K. Horiuchi, C. Blobel, Y. Okada, 2022 .

IL-27 Abrogates Receptor Activator of NF-κB Ligand-Mediated Osteoclastogenesis of Human Granulocyte-Macrophage Colony-Forming Unit Cells through STAT1-Dependent Inhibition of c-Fos1

Y. Okada, Y. Toyama, K. Matsuo, 2009, The Journal of Immunology.

Expression of Ets‐1 in human clear cell renal cell carcinomas: Implications for angiogenesis

Y. Okada, M. Oya, M. Murai, 2006, Cancer science.

The Prognostic Significance of Vasohibin-1 Expression in Patients with Upper Urinary Tract Urothelial Carcinoma

Y. Okada, K. Nakagawa, E. Kikuchi, 2012, Clinical Cancer Research.

Imaging , Diagnosis , Prognosis The Prognostic Signi fi cance of Vasohibin-1 Expression in Patients with Upper Urinary Tract Urothelial Carcinoma

Y. Okada, K. Nakagawa, E. Kikuchi, 2012 .

Increased RANKL expression is related to tumour migration and metastasis of renal cell carcinomas

Y. Okada, M. Oya, R. Mizuno, 2009, The Journal of pathology.

Invasion and metastasis of renal cell carcinoma

Y. Okada, M. Oya, R. Mizuno, 2014, Medical Molecular Morphology.

Host-derived MMP-13 exhibits a protective role in lung metastasis of melanoma cells by local endostatin production

Y. Okada, J. D’Armiento, H. Okano, 2011, British Journal of Cancer.

SOX4, an epithelial–mesenchymal transition inducer, transactivates ADAM28 gene expression and co‐localizes with ADAM28 at the invasive front of human breast and lung carcinomas

Y. Okada, M. Shimoda, S. Mochizuki, 2018, Pathology international.

Stroma-derived matrix metalloproteinase (MMP)-2 promotes membrane type 1-MMP-dependent tumor growth in mice.

Shigeyoshi Itohara, Motoharu Seiki, Takahiro Nonaka, 2007, Cancer research.

Front-cell-specific expression of membrane-type 1 matrix metalloproteinase and gelatinase A during cohort migration of colon carcinoma cells induced by hepatocyte growth factor/scatter factor.

Y. Okada, T. Inoue, K. Nabeshima, 2000, Cancer research.

Embryonic expression profile of chicken CHD7, the ortholog of the causative gene for CHARGE syndrome.

Y. Okada, R. Kosaki, K. Kosaki, 2007, Birth defects research. Part A, Clinical and molecular teratology.

PIAS3 negatively regulates RANKL-mediated osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblasts.

Y. Okada, A. Yoshimura, Y. Toyama, 2009, Blood.

Zymographic analysis of circulating and tissue forms of colon carcinoma gelatinase A (MMP-2) and B (MMP-9) separated by mono- and two-dimensional electrophoresis.

Y. Okada, S. Fontana, I. Pucci‐Minafra, 2001, Matrix biology : journal of the International Society for Matrix Biology.

Inhibitory effects of Sanguisorba officinalis root extract on HYBID (KIAA1199)‐mediated hyaluronan degradation and skin wrinkling

Y. Okada, S. Kasamatsu, H. Yoshida, 2019, International journal of cosmetic science.

Inhibition of STAT1 accelerates bone fracture healing

Jiro Takito, Yoshiaki Toyama, Hiroyasu Ikegami, 2010, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

HYBID derived from tumor cells and tumor-associated macrophages contribute to the glioblastoma growth

Y. Okada, H. Hara, M. Shimazawa, 2021, Brain Research.

Expression of Matrix Metalloproteinases in Gastric Carcinoma and Possibility of Clinical Application of Matrix Metalloproteinase Inhibitor in Vivo

Y. Okada, T. Kubota, Y. Otani, 1999, Annals of the New York Academy of Sciences.

Invasive lobular carcinoma arising in phyllodes tumor of the breast

Y. Okada, T. Kodama, T. Ikeda, 2003, Virchows Archiv.

Production of matrix metalloproteinases at the bone-implant interface in loose total hip replacements.

Y. Okada, N. Fujimoto, K. Imai, 1995, Laboratory investigation; a journal of technical methods and pathology.

Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis

Shinsuke Yuasa, Keiichi Fukuda, Kensuke Kimura, 2006, Nature Medicine.

Inhibition of MKP-1 expression potentiates JNK related apoptosis in renal cancer cells.

T. Shiomi, Y. Okada, M. Oya, 2004, The Journal of urology.

Activation of aryl hydrocarbon receptor promotes invasion of clear cell renal cell carcinoma and is associated with poor prognosis and cigarette smoke

Y. Okada, E. Kikuchi, A. Miyajima, 2015, International journal of cancer.

Chest High-Resolution CT Findings of Microscopic Polyangiitis: A Japanese First Nationwide Prospective Cohort Study.

Y. Okada, A. Ishizu, K. Yamagata, 2019, AJR. American journal of roentgenology.

A large coronary aneurysm and its probable precursor lesions in a patient with autosomal dominant polycystic kidney disease: An implication for the process of aneurysmogenesis

Y. Okada, S. Wakino, H. Itoh, 2012, Pathology international.

Purification and refolding of recombinant human proMMP-7 (pro-matrilysin) expressed in Escherichia coli and its characterization.

Y. Okada, H. Sato, M. Seiki, 1996, Journal of biochemistry.

Enhanced production and activation of matrix metalloproteinase‐7 (matrilysin) in human endometrial carcinomas

Y. Okada, H. Ueno, M. Inoue, 1999, International journal of cancer.

Expression and tissue localization of matrix metalloproteinase 7 (matrilysin) in human gastric carcinomas. Implications for vessel invasion and metastasis

Y. Okada, M. Mai, Y Okada, 1998, International journal of cancer.

Increased vasohibin-1 expression is associated with metastasis and poor prognosis of renal cell carcinoma patients.

Y. Okada, M. Oya, R. Mizuno, 2017, Laboratory investigation; a journal of technical methods and pathology.

Membrane‐type 1 MMP (MMP‐14) cleaves at three sites in the aggrecan interglobular domain

Y. Okada, M. Seiki, A. Fosang, 1998, FEBS letters.

Membrane-Type Matrix Metalloproteinases (MT-MMPs) in Cell Invasion

Y. Okada, Hiroshi Sato, M. Seiki, 1997, Thrombosis and Haemostasis.

Enhanced production of matrix metalloproteinases and activation of matrix metalloproteinase 2 (gelatinase A) in human gastric carcinomas

Y. Okada, M. Mai, M. Seiki, 1996, International journal of cancer.

A critical role for ABC transporters in persistent lung inflammation in the development of emphysema after smoke exposure

Y. Okada, V. Lemaître, M. Westerterp, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[A patient with giant cell myocarditis and myositis associated with thymoma and myasthenia gravis].

Y. Okada, Y. Fukuuchi, S. Nogawa, 2003, Rinsho shinkeigaku = Clinical neurology.

Neuromuscular and vascular hamartoma of the cecum

T. Shiomi, Y. Okada, K. Kameyama, 2002, Virchows Archiv.

Progressive adult-onset emphysema in transgenic mice expressing human MMP-1 in the lung.

Y. Okada, J. D’Armiento, R. Foronjy, 2003, American journal of physiology. Lung cellular and molecular physiology.

Brevican Is Degraded by Matrix Metalloproteinases and Aggrecanase-1 (ADAMTS4) at Different Sites*

Y. Okada, Y. Yamaguchi, K. Tanzawa, 2000, The Journal of Biological Chemistry.

Human glioblastomas overexpress ADAMTS-5 that degrades brevican

Mitsutoshi Nakada, Tomoya Takahashi, Y. Okada, 2005, Acta Neuropathologica.

Monoclonal antibodies with defined recognition sequences in the stem region of CD44: detection of differential glycosylation of CD44 between tumor and stromal cells in tissue.

Y. Okada, M. Seiki, K. Iwata, 2003, Cancer research.

Research article Open Access Expression of ADAM15 in rheumatoid synovium: up-regulation by

Y. Okada, Y. Toyama, H. Matsumoto, 2022 .

Inhibition of membrane-type 1 matrix metalloproteinase by hydroxamate inhibitors: an examination of the subsite pocket.

Y. Okada, M. Yamamoto, H. Tsujishita, 1998, Journal of medicinal chemistry.

Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes

Y Fujita, Y. Okada, Y. Toyama, 2008, Annals of the rheumatic diseases.

Transgenic expression of matrix metalloproteinase-9 causes adult-onset emphysema in mice associated with the loss of alveolar elastin.

Takwi Nkyimbeng, Y. Okada, J. D’Armiento, 2008, American journal of physiology. Lung cellular and molecular physiology.

[Drug induced hemolytic anemia associated with agranulocytosis].

Y. Okada, Y. Hinoda, M. Adachi, 1996, Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology.

A case of sclerosing hemangioma of the lung presenting as a gigantic tumor occupying the left thoracic cavity

Y. Okada, M. Sakamoto, M. Mukai, 2003, Virchows Archiv.

Inhibition of HYBID (KIAA1199)‐mediated hyaluronan degradation and anti‐wrinkle effect of Geranium thunbergii extract

Y. Okada, S. Kasamatsu, H. Yoshida, 2018, Journal of cosmetic dermatology.

KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization

Yoshinori Sugiyama, Shintaro Inoue, Hiroyuki Yoshida, 2013, Proceedings of the National Academy of Sciences.

STRUCTURAL EMPHYSEMA DOES NOT CORRELATE WITH LUNG COMPLIANCE: LESSONS FROM THE MOUSE SMOKING MODEL

Y. Okada, J. D’Armiento, C. Powell, 2005, Experimental lung research.

Chapter 8 – Proteinases and Matrix Degradation

Y. Okada, Yasunori Okada, 2017 .

Matrix-degrading metalloproteinases and their roles in joint destruction

Y. Okada, Yasunori Okada, 2000, Modern rheumatology.

Significance of tumor microenvironment in acquiring resistance to vascular endothelial growth factor‐tyrosine kinase inhibitor and recent advance of systemic treatment of clear cell renal cell carcinoma

Y. Okada, M. Oya, Y. Nagashima, 2020, Pathology international.

Targeted deletion of HYBID (hyaluronan binding protein involved in hyaluronan depolymerization/ KIAA1199/CEMIP) decreases dendritic spine density in the dentate gyrus through hyaluronan accumulation.

Y. Okada, H. Hara, M. Shimoda, 2018, Biochemical and biophysical research communications.

Transgenic expression of matrix metalloproteinase-9 modulates collagen deposition in a mouse model of atherosclerosis.

Y. Okada, J. D’Armiento, V. Lemaître, 2009, Atherosclerosis.

Activation of pro‐MMP‐2 mediated by MT1‐MMP in human salivary gland carcinomas: possible regulation of pro‐MMP‐2 activation by TIMP‐2

Y. Okada, M. Seiki, T. Aoki, 2004, The Journal of pathology.

Prognostic significance of erythrocyte protein band 4.1-like5 expression in upper urinary tract urothelial carcinoma.

Y. Okada, E. Kikuchi, A. Miyajima, 2017, Urologic oncology.

Imaging , Diagnosis , Prognosis Expression of Snail in Upper Urinary Tract Urothelial Carcinoma : Prognostic Significance and Implications for Tumor Invasion

Y. Okada, E. Kikuchi, A. Miyajima, 2010 .

Joint diseases and matrix metalloproteinases: a role for MMP-13.

Y. Okada, J. D’Armiento, Tokuhiro Kimura, 2008, Current pharmaceutical biotechnology.

Basaloid squamous carcinoma of the hypopharynx with an extensive spindle cell component exhibiting a pedunculated polypoid mass.

A. Shiotani, Y. Okada, M. Mukai, 2009, Archives of pathology & laboratory medicine.

Development of human neutralizing antibody to ADAMTS4 (aggrecanase-1) and ADAMTS5 (aggrecanase-2).

Y. Okada, K. Kojoh, S. Mochizuki, 2016, Biochemical and biophysical research communications.

Accumulation of Secretory Vesicles in the Lacrimal Gland Epithelia Is Related to Non-Sjögren's Type Dry Eye in Visual Display Terminal Users

Y. Okada, K. Tsubota, T. Kawakita, 2012, PloS one.

ADAM28 is activated by MMP-7 (matrilysin-1) and cleaves insulin-like growth factor binding protein-3.

Masayuki Shimoda, Yutaka Fujii, T. Shiomi, 2004, Biochemical and biophysical research communications.

Computed Tomographic Attenuation Value of Coronary Atherosclerotic Plaques With Different Tube Voltage: An Ex Vivo Study

M. Jinzaki, Y. Okada, S. Kuribayashi, 2010, Journal of computer assisted tomography.

Matrix Metalloproteinase‐9 and Tensile Strength of Fetal Membranes in Uncomplicated Labor

Y. Okada, N. Fujimoto, K. Uchide, 2000, Obstetrics and gynecology.

Selective Inhibition of ADAM28 Suppresses Lung Carcinoma Cell Growth and Metastasis

H. Ueno, Y. Okada, M. Shimoda, 2018, Molecular Cancer Therapeutics.

From microscopy data to in silico environments for in vivo-oriented simulations

Heinz Koeppl, Noriko Hiroi, Akira Funahashi, 2012, EURASIP J. Bioinform. Syst. Biol..

Physiological Intracellular Crowdedness is Defined by the Perimeter-to-Area Ratio of Sub-Cellular Compartments

Noriko Hiroi, Keisuke Iba, Akito Tabira, 2012, Front. Physio..

Nontuberculous mycobacteria‐associated spindle cell pseudotumor of the nasal cavity: A case report

Y. Okada, Tokuhiro Kimura, Kentaro Ohara, 2013, Pathology international.

ADAM23 is downregulated in side population and suppresses lung metastasis of lung carcinoma cells

Y. Okada, M. Shimoda, S. Mochizuki, 2016, Cancer science.

Y. Okada, Hiroshi Sato, M. Seiki, 1995, International journal of cancer.

osteoclast precursors and indirectly via osteoblasts PIAS3 negatively regulates RANKL-mediated osteoclastogenesis directly in

Y. Okada, A. Yoshimura, Y. Toyama, 2013 .

Expression and Characterization of Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization: HYBID, Alias KIAA1199 and CEMIP.

Y. Okada, S. de Vega, H. Yoshida, 2020, Methods in molecular biology.

Matrix metalloproteinases and tissue inhibitor of metalloproteinase-2 in fetal rabbit lung.

Y. Okada, Y. Fukuda, M. Ishizaki, 2000 .

ADAM28 as a target for human cancers.

Y. Okada, S. Mochizuki, 2009, Current pharmaceutical design.

Modulation of the microenvironment and adhesion of cancer cells by ADAMs (a disintegrin and metalloproteinase).

Y. Okada, 2007, Verhandlungen der Deutschen Gesellschaft fur Pathologie.

Cancer‐associated fibroblasts at the unfavorable desmoplastic stroma promote colorectal cancer aggressiveness: Potential role of ADAM9

H. Ueno, Y. Okada, Y. Kajiwara, 2022, International journal of cancer.

Identification of a Prosencephalic-Specific Enhancer of SALL1: Comparative Genomic Approach Using the Chick Embryo

Y. Okada, J. Golden, K. Kosaki, 2007, Pediatric Research.

Conditional Inactivation of TACE by a Sox9 Promoter Leads to Osteoporosis and Increased Granulopoiesis via Dysregulation of IL-17 and G-CSF1

K. Horiuchi, C. Blobel, Y. Okada, 2009, The Journal of Immunology.

ADAM28 is expressed by epithelial cells in human normal tissues and protects from C1q‐induced cell death

Y. Okada, M. Shimoda, Y. Kitagawa, 2016, The FEBS Journal.

Src plays a key role in ADAM28 expression in v-src-transformed epithelial cells and human carcinoma cells.

Y. Okada, Hiroshi Sato, O. Hino, 2013, American Journal of Pathology.

Neutrophil-Derived Matrix Metalloproteinase 9 Triggers Acute Aortic Dissection

Y. Okada, S. Weiss, H. Itoh, 2012, Circulation.

KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization

Y. Okada, S. Sakai, S. Inoue, 2013, Proceedings of the National Academy of Sciences.

Absence of Gelatinase (MMP-9) or Collagenase (MMP-13) Attenuates Adriamycin-Induced Albuminuria and Glomerulosclerosis

Y. Okada, J. D’Armiento, H. Sasamura, 2010, Nephron Experimental Nephrology.

ApoE knockout mice expressing human matrix metalloproteinase-1 in macrophages have less advanced atherosclerosis.

A. Borczuk, Y. Okada, J. D’Armiento, 2001, The Journal of clinical investigation.

RECK is up-regulated and involved in chondrocyte cloning in human osteoarthritic cartilage.

Y. Okada, Y. Toyama, Tokuhiro Kimura, 2010, The American journal of pathology.

Peking University - Juntendo University Joint Symposium on Cancer Research and Treatment: ADAM28 (a Disintegrin and Metalloproteinase 28) in Cancer Cell Proliferation and Progression

Y. Okada, 2017 .

ADAM12 is selectively overexpressed in human glioblastomas and is associated with glioblastoma cell proliferation and shedding of heparin-binding epidermal growth factor.

T. Shiomi, Y. Okada, T. Kodama, 2004, The American journal of pathology.

Importance of tumor necrosis factor-alpha cleavage process in post-transplantation lung injury in rats.

Y. Okada, I. Maruyama, A. Ishizaka, 2004, American journal of respiratory and critical care medicine.

A one-step monoclonal antibody-based sandwich enzyme immunoassay for human active matrilysin (MMP-7) and its complexes with TIMP-1 and TIMP-2

Y. Okada, S. Yoshida, K. Iwata, 1998 .

A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 7 (matrilysin) using monoclonal antibodies.

Y. Okada, S. Yoshida, K. Iwata, 1996, Clinica chimica acta; international journal of clinical chemistry.

SAF‐3, a novel splice variant of the SAF‐1/MAZ/Pur‐1 family, is expressed during inflammation

Y. Okada, A. Shakya, B. Ray, 2009, The FEBS journal.

Expression of Heparanase in Renal Cell Carcinomas: Implications for Tumor Invasion and Prognosis

Y. Okada, M. Oya, M. Nakajima, 2008, Clinical Cancer Research.

Combination effects of nobiletin with CDDP on gastric cancer cells

Y. Okada, T. Kubota, Y. Otani, 2004 .

597 EXPRESSION OF SNAIL IN UPPER URINARY TRACT UROTHELIAL CARCINOMA: PROGNOSTIC SIGNIFICANCE AND IMPLICATIONS FOR TUMOR INVASION

Y. Okada, E. Kikuchi, A. Miyajima, 2011 .

The Citrus Flavonoid, Nobiletin, Inhibits Peritoneal Dissemination of Human Gastric Carcinoma in SCID Mice

Y. Okada, T. Kubota, Y. Otani, 2001, Japanese journal of cancer research : Gann.