C. Gross

发表

Surviving heat shock: control strategies for robustness and performance.

John C. Doyle, J. Doyle, M. Khammash, 2005, Proceedings of the National Academy of Sciences of the United States of America.

A tool-kit for high-throughput, quantitative analyses of genetic interactions in E. coli

Sean R. Collins, H. Mori, N. Krogan, 2008, Nature Methods.

Phenotypic Landscape of a Bacterial Cell

N. Krogan, M. Shales, C. Gross, 2011, Cell.

The sigma 70 family: sequence conservation and evolutionary relationships

M. Gribskov, C. Gross, M. Lonetto, 1992, Journal of bacteriology.

6 Bacterial Sigma Factors

R. Losick, C. Gross, M. Lonetto, 1992 .

Design of orthogonal genetic switches based on a crosstalk map of σs, anti-σs, and promoters

Christopher A. Voigt, Christopher A Voigt, Kevin Clancy, 2013, Molecular Systems Biology.

rpoE, the gene encoding the second heat‐shock sigma factor, sigma E, in Escherichia coli.

K. Rudd, C. Gross, P. Rouvière, 1995, The EMBO journal.

SigmaE is an essential sigma factor in Escherichia coli

C. Gross, A. De Las Peñas, L. Connolly, 1997, Journal of bacteriology.

Multiple sigma subunits and the partitioning of bacterial transcription space.

C. Gross, T. Gruber, T. M. Gruber, 2003, Annual review of microbiology.

Predicting the strength of UP-elements and full-length E. coli σE promoters

Vivek K. Mutalik, C. Gross, V. Rhodius, 2011, Nucleic acids research.

Regulation of the promoters and transcripts of rpoH, the Escherichia coli heat shock regulatory gene.

F. Neidhardt, C. Gross, J. Erickson, 1987, Genes & development.

Crystal Structure of Escherichia coli σE with the Cytoplasmic Domain of Its Anti-σ RseA

C. Gross, J. Tupy, T. Gruber, 2003 .

The interface of sigma with core RNA polymerase is extensive, conserved, and functionally specialized.

C. Gross, J. Roberts, S. Nechaev, 1999, Genes & development.

Insights into transcriptional regulation and sigma competition from an equilibrium model of RNA polymerase binding to DNA.

Vivek K. Mutalik, C. Gross, I. Grigorova, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Conserved and Variable Functions of the σE Stress Response in Related Genomes

C. Gross, V. Rhodius, W. Suh, 2005, PLoS biology.

Stress-Induced Remodeling of the Bacterial Proteome

Carol A. Gross, C. Gross, Monica S Guo, 2014, Current Biology.

Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs

Thomas M. Norman, Max A. Horlbeck, John S. Hawkins, 2019, Nature Biotechnology.

Titrating gene expression with series of systematically compromised CRISPR guide RNAs

Thomas M. Norman, Max A. Horlbeck, John S. Hawkins, 2019, bioRxiv.

Selective Ribosome Profiling Reveals the Cotranslational Chaperone Action of Trigger Factor In Vivo

J. Weissman, C. Gross, A. Typas, 2011, Cell.

A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria

John S. Hawkins, Lei S. Qi, J. Weissman, 2016, Cell.

A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response

Thomas M. Norman, Max A. Horlbeck, Luke A. Gilbert, 2016, Cell.

Ceragenins and Antimicrobial Peptides Kill Bacteria through Distinct Mechanisms

C. Gross, D. Licht, P. Savage, 2020, bioRxiv.

Quantifying Absolute Protein Synthesis Rates Reveals Principles Underlying Allocation of Cellular Resources

David H Burkhardt, David H. Burkhardt, Gene-Wei Li, 2014, Cell.

Bacterial sigma factors: a historical, structural, and genomic perspective.

Brian D Sharon, C. Gross, S. Darst, 2014, Annual review of microbiology.

Construction and Analysis of Two Genome-Scale Deletion Libraries for Bacillus subtilis.

Marco Galardini, George Kritikos, Ilan Wapinski, 2017, Cell systems.

The SurA periplasmic PPIase lacking its parvulin domains functions in vivo and has chaperone activity

C. Gross, F. Schmid, H. de Cock, 2001, The EMBO journal.

Regulation of peptidoglycan synthesis by outer membrane proteins

Waldemar Vollmer, Carol A. Gross, Robert J. Nichols, 2010, Cell.

Isolation and characterization of Escherichia coli mutants that lack the heat shock sigma factor sigma 32

C. Gross, J. Erickson, T. Yura, 1988, Journal of bacteriology.

The activity of sigma 32 is reduced under conditions of excess heat shock protein production in Escherichia coli.

C. Gross, W. Walter, D B Straus, 1989, Genes & development.

Impact of genomic technologies on studies of bacterial gene expression.

R. Larossa, C. Gross, V. Rhodius, 2002, Annual review of microbiology.

Identification of the binding sites of regulatory proteins in bacterial genomes

Eric D Siggia, Hao Li, E. Siggia, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Directed Evolution of Substrate-Optimized GroEL/S Chaperonins

Jonathan S. Weissman, Carol A. Gross, J. Weissman, 2002, Cell.

THE REGULATION OF TRANSCRIPTION INITIATION BACTERIA IN

D A Siegele, C. Gross, W. Reznikoff, 1985 .

The activity of sigma E, an Escherichia coli heat-inducible sigma-factor, is modulated by expression of outer membrane proteins.

T. Donohue, C. Gross, P. Rouvière, 1993, Genes & development.

A gene regulating the heat shock response in Escherichia coli also affects proteolysis.

A. Grossman, T. Baker, C. Gross, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Genetic interaction mapping informs integrative structure determination of protein complexes

John H. Morris, J. Bader, N. Krogan, 2020, Science.

RNA polymerase and the regulation of transcription

M. Wickens, R. Burgess, C. Gross, 1987 .

The anti-initial transcribed sequence, a portable sequence that impedes promoter escape, requires sigma70 for function.

C. Gross, C. Chan, 2001, Journal of Biological Chemistry.

Using DNA microarrays to assay part function.

C. Gross, V. Rhodius, 2011, Methods in enzymology.

Cellular Response to Heat Shock and Cold Shock

C. Gross, Bentley Lim, 2011 .

DnaK and DnaJ heat shock proteins participate in protein export in Escherichia coli.

C. Gross, T. Yura, E. Altman, 1992, Genes & development.

Fatty Acid Synthesis Knockdown Promotes Biofilm Wrinkling and Inhibits Sporulation in Bacillus subtilis

C. Gross, K. C. Huang, Esha Atolia, 2022, bioRxiv.

MurJ and a novel lipid II flippase are required for cell wall biogenesis in Bacillus subtilis

C. Gross, D. Rudner, Lok-To Sham, 2015, Proceedings of the National Academy of Sciences.

Mutational analysis of Escherichia coli σ28 and its target promoters reveals recognition of a composite −10 region, comprised of an ‘extended −10’ motif and a core −10 element

C. Gross, V. Rhodius, E. Campbell, 2009, Molecular microbiology.

Involvement of the DnaK-DnaJ-GrpE chaperone team in protein secretion in Escherichia coli

C. Gross, W. Walter, P. Rossmeissl, 1996, Journal of bacteriology.

Accumulation of secretory protein precursors in Escherichia coli induces the heat shock response

C. Gross, W. Walter, E. Altman, 1993, Journal of bacteriology.

Characterization of the pleiotropic phenotypes of rifampin-resistant rpoB mutants of Escherichia coli

C. Gross, D. Jin, 1989, Journal of bacteriology.

Regulation of the Heat-Shock Response in Escherichia coli

A. Grossman, C. Gross, J. Erickson, 1987 .

Mutations in the Lon gene of E. coli K12 phenotypically suppress a mutation in the sigma subunit of RNA polymerase

A. Grossman, R. Burgess, C. Gross, 1983, Cell.

RpoB8, a rifampicin-resistant termination-proficient RNA polymerase, has an increased Km for purine nucleotides during transcription elongation.

C. Gross, D. Jin, 1991, The Journal of biological chemistry.

Marker rescue with plasmids bearing deletions in rpoD identifies a dispensable part of E. coli sigma factor

James C. Hu, C. Gross, 2004, Molecular and General Genetics MGG.

Amino Acid Substitutions in the Two Largest Subunits of Escherichia coli RNA Polymerase That Suppress a Defective Rho Termination Factor Affect Different Parts of the Transcription Complex*

C. Gross, R. Landick, D. Jin, 1996, The Journal of Biological Chemistry.

the of UP-elements and full-length E. coli σE promoters.

Vivek K. Mutalik, C. Gross, V. Rhodius, 2012 .

Isolation, purification, and in vitro characterization of recessive-lethal-mutant RNA polymerases from Escherichia coli

C. Gross, R. Landick, P. Tavormina, 1996, Journal of bacteriology.

Four contiguous amino acids define the target for streptolydigin resistance in the beta subunit of Escherichia coli RNA polymerase.

C. Gross, R. Landick, H. Suzuki, 1993, The Journal of biological chemistry.

Rewiring the specificity of extracytoplasmic function sigma factors

Kevin S. Myers, T. Donohue, Hao Li, 2020, Proceedings of the National Academy of Sciences.

Stringent response in Escherichia coli induces expression of heat shock proteins.

A. Grossman, R. Burgess, C. Gross, 1985, Journal of molecular biology.

Mu dX, a derivative of Mu d1 (lac Apr) which makes stable lacZ fusions at high temperature

T. Baker, C. Gross, M. Howe, 1983, Journal of bacteriology.

Analysis of Three DnaK Mutant Proteins Suggests That Progression through the ATPase Cycle Requires Conformational Changes (*)

C. Gross, M. Lonetto, W. Suh, 1995, The Journal of Biological Chemistry.

Effects of rifampicin resistant rpoB mutations on antitermination and interaction with nusA in Escherichia coli.

Y. Nakamura, C. Gross, W. Walter, 1988, Journal of molecular biology.

Characterization of the termination phenotypes of rifampicin-resistant mutants.

C. Gross, W. Walter, D. Jin, 1988, Journal of molecular biology.

-Mediated Cytoplasmic Stress Response in Escherichia coli ‡

C. Gross, V. Rhodius, N. Ahuja, 2007 .

Mutations in rpoD that increase expression of genes in the mal regulon of Escherichia coli K-12.

C. Gross, J. Hu, J. C. Hu, 1988, Journal of molecular biology.

Measurement of binding constants for protein-DNA interactions by DNA-cellulose chromatography.

R. Burgess, C. Gross, P. Dehaseth, 1977, Biochemistry.

Analysis of sigma32 mutants defective in chaperone-mediated feedback control reveals unexpected complexity of the heat shock response.

C. Gross, E. Campbell, T. Yura, 2007, Proceedings of the National Academy of Sciences of the United States of America.

Resistance to serine in Bacillus subtilis: identification of the serine transporter YbeC and of a metabolic network that links serine and threonine metabolism

C. Gross, R. Daniel, Anja Poehlein, 2020, bioRxiv.

Identification of the a^ subunit of Escherichia coli RNA polymerase: a second alternate a factor involved in high-temperature gene expression

C. Gross, J. Erickson, 2007 .

Mutations in the sigma subunit of E. coli RNA polymerase which affect positive control of transcription

James C. Hu, C. Gross, 2004, Molecular and General Genetics MGG.

Mutations in the rpoH (htpR) gene of Escherichia coli K-12 phenotypically suppress a temperature-sensitive mutant defective in the sigma 70 subunit of RNA polymerase

A. Grossman, C. Gross, G. Christie, 1985, Journal of bacteriology.

Ira Herskowitz (1946–2003)

C. Gross, F. Stahl, 2003, Cell.

Mutation affecting thermostability coli RNA polymerase lies near the on the E. coli genetic map (transcription/rpoDl /RNA nucleotidyltransferase)

R. Burgess, C. Gross, J. Hoffman, 2016 .

Three rpoBC mutations that suppress the termination defects of rho mutants also affect the functions of nusA mutants

C. Gross, D. Jin, 1989, Molecular and General Genetics MGG.

How a Mutation in the Gene Encoding cr70 Suppresses the Defective Heat Shock Response Caused by a Mutation in the Gene Encoding 32

C. Gross, Yan Ning ZHOUt, 2022 .

Unexpected Stress-Reducing Effect of PhaP, a Poly(3-Hydroxybutyrate) Granule-Associated Protein, in Escherichia coli

C. Gross, V. Rhodius, M. Pettinari, 2011, Applied and Environmental Microbiology.

Covalent intermediate in the catalytic mechanism of the radical S-adenosyl-L-methionine methyl synthase RlmN trapped by mutagenesis.

C. Gross, K. Medzihradszky, R. Nichols, 2012, Journal of the American Chemical Society.

Binding of the Initiation Factor σ70 to Core RNA Polymerase Is a Multistep Process

R. Burgess, C. Gross, K. Severinov, 2001 .

A pause sequence enriched at translation start sites drives transcription dynamics in vivo

Steven M. Block, William J. Greenleaf, Jonathan S. Weissman, 2014, Science.

A structure/function analysis of Escherichia coli RNA polymerase.

C. Gross, M. Lonetto, C. Chan, 1996, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

DksA regulates RNA polymerase in Escherichia coli through a network of interactions in the secondary channel that includes Sequence Insertion 1

C. Gross, D. Schneidman-Duhovny, A. Shiver, 2015, Proceedings of the National Academy of Sciences.

Identification of a contact site for different transcription activators in region 4 of the Escherichia coli RNA polymerase sigma70 subunit.

C. Gross, S. Busby, M. Lonetto, 1998, Journal of molecular biology.

Sigma domain structure: one down, one to go.

C. Gross, M. Lonetto, C. Chan, 1996, Structure.

Altered promoter recognition by mutant forms of the sigma 70 subunit of Escherichia coli RNA polymerase.

James C. Hu, C. Gross, D. Siegele, 1989, Journal of molecular biology.

Altering the interaction between sigma70 and RNA polymerase generates complexes with distinct transcription-elongation properties.

C. Gross, C. Lu, Y. Berghöfer‐Hochheimer, 2005, Proceedings of the National Academy of Sciences of the United States of America.

A hydrophobic patch on the flap-tip helix of E.coli RNA polymerase mediates sigma(70) region 4 function.

C. Gross, T. Gruber, R. Landick, 2004, Journal of molecular biology.

Assay of Escherichia coli RNA polymerase: sigma-core interactions.

C. Gross, T. Gruber, T. M. Gruber, 2003, Methods in enzymology.

Views of Transcription Initiation

C. Gross, T. Gruber, B. A. Young, 2002, Cell.

A Coiled-Coil from the RNA Polymerase β′ Subunit Allosterically Induces Selective Nontemplate Strand Binding by σ70

R. Burgess, C. Gross, T. Gruber, 2001, Cell.

Development of RNA polymerase-promoter contacts during open complex formation.

C. Gross, J. Mecsas, D. Cowing, 1991, Journal of molecular biology.

Mapping and sequencing of mutations in the Escherichia coli rpoB gene that lead to rifampicin resistance.

C. Gross, D. Jin, 1988, Journal of molecular biology.

Reduced capacity of alternative sigmas to melt promoters ensures stringent promoter recognition.

C. Gross, P. Dehaseth, V. Rhodius, 2009, Genes & development.

Minimal Machinery of RNA Polymerase Holoenzyme Sufficient for Promoter Melting

C. Gross, T. Gruber, B. A. Young, 2004, Science.

The functional and regulatory roles of sigma factors in transcription.

C. Gross, J. Tupy, T. Gruber, 1998, Cold Spring Harbor symposia on quantitative biology.

Intermediates in the formation of the open complex by RNA polymerase holoenzyme containing the sigma factor sigma 32 at the groE promoter.

C. Gross, J. Mecsas, M. Record, 1989, Journal of molecular biology.

Rewiring the specificity of extracytoplasmic function sigma factors

Kevin S. Myers, T. Donohue, Hao Li, 2020, Proceedings of the National Academy of Sciences.

Chemical-genetic interrogation of RNA polymerase mutants reveals structure-function relationships and physiological tradeoffs.

James C. Hu, N. Krogan, C. Gross, 2021, Molecular cell.

Chemical-genetic interrogation of RNA polymerase mutants reveals structure-function relationships and physiological tradeoffs

James C. Hu, C. Gross, K. C. Huang, 2020, bioRxiv.

Identifying Interacting Regions in theβSubunit ofEscherichia coliRNA Polymerase

C. Gross, W. Reznikoff, P. Tavormina, 1996 .

Identifying interacting regions in the beta subunit of Escherichia coli RNA polymerase.

C. Gross, W. Reznikoff, P. Tavormina, 1996, Journal of molecular biology.

Marine Mammal Microbiota Yields Novel Antibiotic with Potent Activity Against Clostridium difficile.

Roger G. Linington, C. Gross, K. C. Huang, 2018, ACS infectious diseases.

Equilibrium and kinetic studies of Escherichia coli lac repressor-inducer interactions.

P. V. von Hippel, C. Gross, S. Laiken, 1972, Journal of molecular biology.

Quantitation of RNA polymerase subunits in Escherichia coli during exponential growth and after bacteriophage T4 infection

R. Burgess, C. Gross, F. Engbaek, 2004, Molecular and General Genetics MGG.

Characterization of Six Lipoproteins in the σE Regulon

C. Gross, F. Fang, C. Onufryk, 2005 .

MicL, a new σE-dependent sRNA, combats envelope stress by repressing synthesis of Lpp, the major outer membrane lipoprotein

G. Storz, C. Gross, S. Shabalina, 2014, Genes & development.

The context of the ribosome binding site in mRNAs defines specificity of action of kasugamycin, an inhibitor of translation initiation

D. Klepacki, C. Gross, A. Mankin, 2022, Proceedings of the National Academy of Sciences.

SurA, a periplasmic protein with peptidyl-prolyl isomerase activity, participates in the assembly of outer membrane porins.

C. Gross, P. Rouvière, 1996, Genes & development.

Coordination of peptidoglycan synthesis and outer membrane constriction during Escherichia coli cell division

C. Gross, K. C. Huang, J. Simorre, 2015, eLife.

From the regulation of peptidoglycan synthesis to bacterial growth and morphology

C. Gross, W. Vollmer, M. Banzhaf, 2011, Nature Reviews Microbiology.

Interaction of Lac Repressor with Non-Specific DNA Binding Sites

C. Gross, A. Revzin, P. V. Hippel, 1975 .

Bacterial CRISPR: accomplishments and prospects.

John S. Hawkins, Lei S. Qi, C. Gross, 2015, Current opinion in microbiology.

Three bacterial DedA subfamilies with distinct functions and phylogenetic distribution

C. Gross, Horia Todor, N. Herrera, 2023, bioRxiv.

repressing synthesis of Lpp , the major outer membrane lipoprotein-dependent sRNA , combats envelope stress byE σ MicL , a new Material Supplemental

G. Storz, C. Gross, S. Shabalina, 2014 .

Non-specific DNA binding of genome regulating proteins as a biological control mechanism: I. The lac operon: equilibrium aspects.

P. V. von Hippel, C. Gross, A. Revzin, 1974, Proceedings of the National Academy of Sciences of the United States of America.

The Escherichia coli ts8 mutation is an allele of fda, the gene encoding fructose-1,6-diphosphate aldolase

C. Gross, M. Singer, B. M. Cali, 1991, Journal of bacteriology.

Global analysis of translation termination in E. coli

C. Gross, Yan Zhang, N. Baggett, 2017, PLoS genetics.

A collection of strains containing genetically linked alternating antibiotic resistance elements for genetic mapping of Escherichia coli.

A. Grossman, C. Gross, M. Singer, 1989, Microbiological reviews.

The crystal structure of the periplasmic domain of Vibrio parahaemolyticus CpxA

C. Gross, T. Ngo, K. Kim, 2012, Protein science : a publication of the Protein Society.

The htpR gene product of E. coli is a sigma factor for heat-shock promoters

A. Grossman, C. Gross, J. Erickson, 1984, Cell.

A mutant sigma 32 with a small deletion in conserved region 3 of sigma has reduced affinity for core RNA polymerase

C. Gross, W. Walter, Y. Zhou, 1992, Journal of bacteriology.

Is hsp70 the cellular thermometer?

C. Gross, E. Craig, C A Gross, 1991, Trends in biochemical sciences.

Identification of the sigma E subunit of Escherichia coli RNA polymerase: a second alternate sigma factor involved in high-temperature gene expression.

C. Gross, J. Erickson, 1989, Genes & development.

The heat shock response of E. coli is regulated by changes in the concentration of σ32

Carol A. Gross, C. Gross, W. Walter, 1987, Nature.

Consensus sequence for Escherichia coli heat shock gene promoters.

C. Gross, E. Craig, J. Bardwell, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Transcription from a heat-inducible promoter causes heat shock regulation of the sigma subunit of E. coli RNA polymerase

A. Grossman, R. Burgess, C. Gross, 1984, Cell.

A chaperone network controls the heat shock response in E. coli.

Carol A Gross, C. Gross, Christophe Herman, 2004, Genes & development.

Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs

Thomas M. Norman, Max A. Horlbeck, John S. Hawkins, 2019, Nature Biotechnology.

Convergence of Molecular, Modeling, and Systems Approaches for an Understanding of the Escherichia coli Heat Shock Response

Takashi Yura, Carol A. Gross, C. Gross, 2008, Microbiology and Molecular Biology Reviews.

sigma mutation, glucose, and chloramphenicol. Escherichia coli K-12: effects of the rpoD800 Regulation of cyclic AMP synthesis in

A. Grossman, R. Burgess, C. Gross, 2013 .

Regulation of cyclic AMP synthesis in Escherichia coli K-12: effects of the rpoD800 sigma mutation, glucose, and chloramphenicol

A. Grossman, R. Burgess, C. Gross, 1984, Journal of bacteriology.

Mismatch-CRISPRi Reveals the Co-varying Expression-Fitness Relationships of Essential Genes in Escherichia coli and Bacillus subtilis.

John S. Hawkins, J. Weissman, C. Gross, 2020, Cell systems.

Modulated efficacy CRISPRi reveals evolutionary conservation of essential gene expression-fitness relationships in bacteria

John S. Hawkins, J. Weissman, C. Gross, 2019, bioRxiv.

A Stress Response that Monitors and Regulates mRNA Structure Is Central to Cold Shock Adaptation.

David H Burkhardt, David H. Burkhardt, Gene-Wei Li, 2018, Molecular cell.

Operon mRNAs are organized into ORF-centric structures that predict translation efficiency

David H Burkhardt, Gene-Wei Li, J. Weissman, 2017, eLife.

Substitutions in Bacteriophage T4 AsiA andEscherichia coli ς70 That Suppress T4motA Activation Mutations

C. Gross, M. Sharp, K. Kreuzer, 2001 .

Interaction of the Hsp70 molecular chaperone, DnaK, with its cochaperone DnaJ.

C. Gross, W. Burkholder, C. Lu, 1998, Proceedings of the National Academy of Sciences of the United States of America.

High-throughput bacterial functional genomics in the sequencing era.

C. Gross, A. Shiver, J. Peters, 2015, Current opinion in microbiology.

The operen that encodes the sigma subunit of RNA polymerase also encodes ribosomal protein S21 and DNA primase in E. coli K12

R. Burgess, C. Gross, Z. Burton, 1983, Cell.

Regulon and promoter analysis of the E. coli heat-shock factor, sigma32, reveals a multifaceted cellular response to heat stress.

Virgil A Rhodius, Carol A Gross, C. Gross, 2006, Genes & development.

Topoisomerase IV can functionally replace all type 1A topoisomerases in Bacillus subtilis

C. Gross, R. Daniel, J. Stülke, 2019, Nucleic acids research.

Termination efficiency at rho-dependent terminators depends on kinetic coupling between RNA polymerase and rho.

R. Burgess, C. Gross, J. Richardson, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Small RNAs endow a transcriptional activator with essential repressor functions for single-tier control of a global stress regulon

Jörg Vogel, Virgil A Rhodius, Carol A Gross, 2011, Proceedings of the National Academy of Sciences.

Polypeptides containing highly conserved regions of transcription initiation factor σ 70 exhibit specificity of binding to promoter DNA

C. Gross, W. Walter, M. Record, 1992, Cell.

Morphological and Transcriptional Responses to CRISPRi Knockdown of Essential Genes in Escherichia coli

C. Gross, K. C. Huang, Horia Todor, 2021, mBio.

Substitutions in bacteriophage T4 AsiA and Escherichia coli sigma(70) that suppress T4 motA activation mutations.

C. Gross, M. Sharp, K. Kreuzer, 2001, Journal of Bacteriology.

Mutations in rpoD, the gene encoding the sigma 70 subunit of Escherichia coli RNA polymerase, that increase expression of the lac operon in the absence of CAP-cAMP.

C. Gross, D. Siegele, J. Hu, 1988, Journal of molecular biology.

Dual Molecular Signals Mediate the Bacterial Response to Outer-Membrane Stress

R. Sauer, C. Gross, Rachna Chaba, 2013, Science.

Design principles of the proteolytic cascade governing the sigmaE-mediated envelope stress response in Escherichia coli: keys to graded, buffered, and rapid signal transduction.

T. Baker, C. Gross, J. Flynn, 2007, Genes & development.

Regulation of the Escherichia coliσE‐dependent envelope stress response

C. Gross, B. M. Alba, Benjamin M. Alba, 2004, Molecular microbiology.

Crystal structure of Escherichia coli sigmaE with the cytoplasmic domain of its anti-sigma RseA.

C. Gross, J. Tupy, T. Gruber, 2003, Molecular cell.

Heat Shock Transcription Factor σ32 Co-opts the Signal Recognition Particle to Regulate Protein Homeostasis in E. coli

C. Gross, P. Walter, Koreaki Ito, 2013, PLoS biology.

Ribosomal Architecture: Constraints Imposed by the Need for Self-Production

Jeffrey A. Hussmann, C. Gross, Hendrik Osadnik, 2017, Current Biology.

The Escherichia coli sigma(E)-dependent extracytoplasmic stress response is controlled by the regulated proteolysis of an anti-sigma factor.

Sarah E. Ades, C. Gross, L. Connolly, 1999, Genes & development.

Signal integration by DegS and RseB governs the σE-mediated envelope stress response in Escherichia coli

R. Sauer, C. Gross, Rachna Chaba, 2011, Proceedings of the National Academy of Sciences.

OMP Peptide Signals Initiate the Envelope-Stress Response by Activating DegS Protease via Relief of Inhibition Mediated by Its PDZ Domain

R. Sauer, C. Gross, Baundauna Bose, 2003, Cell.

DegS and YaeL participate sequentially in the cleavage of RseA to activate the sigma(E)-dependent extracytoplasmic stress response.

C. Gross, J. Leeds, B. M. Alba, 2002, Genes & development.

A new mutation rpoD800, affecting the sigma subunit of E. coli RNA polymerase is allelic to two other sigma mutants

R. Burgess, C. Gross, W. Walter, 2004, Molecular and General Genetics MGG.

Effects of the mutant sigma allele rpoD800 on the synthesis of specific macromolecular components of the Escherichia coli K12 cell.

A. Grossman, R. Burgess, C. Gross, 1984, Journal of molecular biology.

Discovery of the extracytoplasmic function σ factors

T. Donohue, C. Gross, M. Lonetto, 2019, Molecular microbiology.

Altered chemical properties in three mutants of E. coli RNA polymerase sigma subunit

R. Burgess, C. Gross, W. Walter, 1979, Molecular and General Genetics MGG.

o* Has Reduced Affinity for Core RNA Polymerase

C. Gross, W. Walter, Y. Zhou, 2022 .

Promoter Strength Properties of the Complete Sigma E Regulon of Escherichia coli and Salmonella enterica

Vivek K. Mutalik, Sarah E. Ades, C. Gross, 2009, Journal of bacteriology.

The response to extracytoplasmic stress in Escherichia coli is controlled by partially overlapping pathways.

C. Gross, A. De Las Peñas, L. Connolly, 1997, Genes & development.

The σE‐mediated response to extracytoplasmic stress in Escherichia coli is transduced by RseA and RseB, two negative regulators of σE

C. Gross, A. De Las Peñas, L. Connolly, 1997, Molecular microbiology.

The activity of cr̂ ^ is reduced under conditions of excess heat shock protein production in Escherichia coli

C. Gross, W. Walter, D. Straus, 2007 .

How a mutation in the gene encoding sigma 70 suppresses the defective heat shock response caused by a mutation in the gene encoding sigma 32

C. Gross, C A Gross, Y. Zhou, 1992, Journal of bacteriology.

A Chemical-Genomic Screen of Neglected Antibiotics Reveals Illicit Transport of Kasugamycin and Blasticidin S

N. Krogan, C. Gross, A. Shiver, 2016, PLoS genetics.

Three-dimensional biofilm colony growth supports a mutualism involving matrix and nutrient sharing

C. Gross, K. C. Huang, L. Willis, 2021, eLife.

Three-dimensional biofilm growth supports a mutualism involving matrix and nutrient sharing

C. Gross, K. C. Huang, L. Willis, 2020, bioRxiv.

Resource A Comprehensive , CRISPR-based Functional Analysis of Essential Genes in Bacteria Graphical Abstract Highlights

John S. Hawkins, Lei S. Qi, J. Weissman, 2022 .

Computational pipeline for designing guide RNAs for mismatch-CRISPRi

John S. Hawkins, C. Gross, Horia Todor, 2021, STAR protocols.

Bacterial CRISPR screens for gene function.

C. Gross, Horia Todor, M. Silvis, 2020, Current opinion in microbiology.

Enabling Genetic Analysis of Diverse Bacteria with Mobile-CRISPRi

John S. Hawkins, J. E. Peters, A. Grossman, 2018, Nature Microbiology.

Mobile-CRISPRi: Enabling Genetic Analysis of Diverse Bacteria

John S. Hawkins, J. E. Peters, A. Grossman, 2018, bioRxiv.

Depletion of Undecaprenyl Pyrophosphate Phosphatases Disrupts Cell Envelope Biogenesis in Bacillus subtilis

C. Gross, E. Garner, J. Helmann, 2016, Journal of bacteriology.

Amino-terminal amino acids modulate sigma-factor DNA-binding activity.

C. Gross, W. Walter, A. Dombroski, 1993, Genes & development.

The nudeotide sequence of the cloned rpoD gene for the RNA polymerase sigma subunit from E. coil K12

R. Burgess, C. Gross, Z. Burton, 1981 .

Sigma 32 synthesis can regulate the synthesis of heat shock proteins in Escherichia coli.

A. Grossman, C. Gross, W. Walter, 1987, Genes & development.

The nucleotide sequence of the cloned rpoD gene for the RNA polymerase sigma subunit from E coli K12.

R. Burgess, C. Gross, Z. Burton, 1981, Nucleic acids research.

Non-specific DNA Binding of Genome Regulating Proteins as a Biological Control Mechanism : 1 . The lac Operon : Equilibrium Aspects ( lac repressor / DNA-protein interactions / RNA polymerase / repressor-inducer complexes )

C. Gross, A. Revzin, P. V. Hippel, 2022 .

A collection of strains containing genetically linked alternating antibiotic resistance elements for genetic mapping of Escherichia coli

A. Grossman, C. Gross, J. Erickson, 1989 .

Module-Based Analysis of Robustness Tradeoffs in the Heat Shock Response System

John Doyle, Hiroyuki Kurata, Mustafa Khammash, 2006, PLoS Comput. Biol..

Editorial overview: Cell regulation: when you think you know it all, there is another layer to be discovered.

C. Gross, A. Gründling, 2015, Current opinion in microbiology.

DnaK, DnaJ, and GrpE are required for flagellum synthesis in Escherichia coli

J. Adler, C. Gross, Y. Zhou, 1992, Journal of bacteriology.

An extra-cytoplasmic function sigma factor and anti-sigma factor control carotenoid biosynthesis in Azospirillum brasilense.

C. Gross, A. Tripathi, J. Vanderleyden, 2008, Microbiology.

Hfq Modulates the σE-Mediated Envelope Stress Response and the σ32-Mediated Cytoplasmic Stress Response in Escherichia coli

C. Gross, V. Rhodius, N. Ahuja, 2006 .

Genetic evidence for the interaction between cluster I and cluster III rifampicin resistant mutations.

C. Gross, M. Singer, W. Walter, 1993, Journal of molecular biology.

degS (hhoB) is an essential Escherichia coli gene whose indispensable function is to provide σE activity

C. Gross, B. M. Alba, H. Zhong, 2001, Molecular microbiology.

Fine-tuning of the Escherichia coli sigmaE envelope stress response relies on multiple mechanisms to inhibit signal-independent proteolysis of the transmembrane anti-sigma factor, RseA.

C. Gross, Rachna Chaba, V. Rhodius, 2004, Genes & development.

Promoter Strength Properties of the Complete Sigma E regulon of E. coli 1

Vivek K. Mutalik, C. Gross, V. Rhodius, 2009 .

The activity of an Escherichia coli heat-inducible r-factor, is modulated by expression of outer membrane proteins

C. Gross, P. Rouvière, J. Mecsas, 2007 .

Translational regulation of sigma 32 synthesis: requirement for an internal control element

C. Gross, A. Kamath-Loeb, C A Gross, 1991, Journal of bacteriology.

Determination of intrinsic transcription termination efficiency by RNA polymerase elongation rate.

C. Gross, J. Roberts, D. Jin, 1994, Science.

Lack of a robust unfoldase activity confers a unique level of substrate specificity to the universal AAA protease FtsH.

C. Gross, A. Matouschek, C. Lu, 2003, Molecular cell.

Partial loss of function mutations in DnaK, the Escherichia coli homologue of the 70-kDa heat shock proteins, affect highly conserved amino acids implicated in ATP binding and hydrolysis.

C. Gross, M. Lonetto, Y. Kawasaki, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Analysis of σ32 mutants defective in chaperone-mediated feedback control reveals unexpected complexity of the heat shock response

C. Gross, E. Campbell, T. Yura, 2007, Proceedings of the National Academy of Sciences.

DnaK, DnaJ, and GrpE heat shock proteins negatively regulate heat shock gene expression by controlling the synthesis and stability of sigma 32.

C. Gross, W. Walter, C A Gross, 1990, Genes & development.

Escherichia coli heat shock gene mutants are defective in proteolysis.

C. Gross, W. Walter, D B Straus, 1988, Genes & development.

Dissection of recognition determinants of Escherichia coli σ32 suggests a composite −10 region with an ‘extended −10’ motif and a core −10 element

C. Gross, V. Rhodius, E. Campbell, 2009, Molecular microbiology.

The sigma subunit of Escherichia coli RNA polymerase senses promoter spacing.

C. Gross, M. Lonetto, A. Dombroski, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Identification of Two Phosphate Starvation-induced Wall Teichoic Acid Hydrolases Provides First Insights into the Degradative Pathway of a Key Bacterial Cell Wall Component*

S. French, E. Brown, C. Gross, 2016, The Journal of Biological Chemistry.

Regulation of the Alternative Sigma Factor σE during Initiation, Adaptation, and Shutoff of the Extracytoplasmic Heat Shock Response in Escherichia coli

Sarah E. Ades, Carol A. Gross, C. Gross, 2003, Journal of bacteriology.

Physiological effects of the fructose-1,6-diphosphate aldolase ts8 mutation on stable RNA synthesis in Escherichia coli

C. Gross, R. Gourse, M. Singer, 1991, Journal of bacteriology.

Three Bacterial DedA Subfamilies with Distinct Functions and Phylogenetic Distribution

C. Gross, Horia Todor, N. Herrera, 2023, mBio.

Expansion and re-classification of the extracytoplasmic function (ECF) σ factor family

C. Gross, A. Goesmann, A. Becker, 2019, bioRxiv.

Structural Features Required for the Interaction of the Hsp70 Molecular Chaperone DnaK with Its Cochaperone DnaJ*

Carol A. Gross, C. Gross, W. Suh, 1999, The Journal of Biological Chemistry.

Identification and characterization of an outer membrane protein, OmpX, in Escherichia coli that is homologous to a family of outer membrane proteins including Ail of Yersinia enterocolitica

C. Gross, J. Mecsas, J. Erickson, 1995, Journal of bacteriology.

Hfq modulates the sigmaE-mediated envelope stress response and the sigma32-mediated cytoplasmic stress response in Escherichia coli.

C. Gross, V. Rhodius, N. Ahuja, 2007, Journal of bacteriology.

Interaction of Escherichia coli RNA polymerase holoenzyme containing sigma 32 with heat shock promoters. DNase I footprinting and methylation protection.

C. Gross, D. Cowing, 1989, Journal of molecular biology.

The Escherichia coli s E -dependent extracytoplasmic stress response is controlled by the regulated proteolysis of an anti- s factor

C. Gross, B. M. Alba, S. Ades, 1999 .

The crystal structure Escherichia coli Spy

C. Gross, K. Kim, Dong Young Kim, 2010, Protein science : a publication of the Protein Society.

The heat shock response of E. coli is regulated by changes in the concentration of sigma 32.

C. Gross, W. Walter, D B Straus, 1987, Nature.

Structure and Function of the Transmembrane Domain of NsaS, an Antibiotic Sensing Histidine Kinase in Staphylococcus aureus.

C. Gross, W. DeGrado, J. Meiler, 2018, Journal of the American Chemical Society.

Cold Shock Response in Bacteria.

C. Gross, Yan Zhang, 2021, Annual review of genetics.

Design of orthogonal genetic switches based on a crosstalk map of σs, anti-σs, and promoters

Christopher A. Voigt, Brian D Sharon, Thomas H. Segall-Shapiro, 2013, Molecular systems biology.

Design of orthogonal genetic switches based on a crosstalk map of r s , anti-r s , and promoters

Brian D Sharon, Thomas H. Segall-Shapiro, David H. Burkhardt, 2013 .

Analyzing the Interaction of RseA and RseB, the Two Negative Regulators of the σE Envelope Stress Response, Using a Combined Bioinformatic and Experimental Strategy*

R. Sauer, C. Gross, Rachna Chaba, 2009, Journal of Biological Chemistry.

Construction and Analysis of Two Genome-Scale Deletion Libraries for Bacillus subtilis.

C. Gross, I. Wapinski, D. Rudner, 2017, Cell systems.

8 The Function and Regulation of Heat Shock Proteins in Escherichia coli

C. Gross, J. Erickson, T. Yura, 1990 .

A Stress Response that Monitors and Regulates mRNA Structure Is Central to Cold Shock Adaptation.

David H. Burkhardt, Gene-Wei Li, J. Weissman, 2018, Molecular cell.

Promoter melting by an alternative σ, one base at a time

C. Gross, S. Darst, A. Feklistov, 2014, Nature Structural &Molecular Biology.