C. Chien

发表

The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest.

S. Fields, C. Chien, P. Bartel, 1991, Proceedings of the National Academy of Sciences of the United States of America.

A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor.

C. Chien, B. Wang, Qing Zhang, 2006, Developmental cell.

An Efficient Screen for Cell-Intrinsic Factors Identifies the Chaperonin CCT and Multiple Conserved Mechanisms as Mediating Dendrite Morphogenesis

C. Chien, Ying-Hsuan Wang, Zhao-Ying Ding, 2020, Frontiers in Cellular Neuroscience.

Targeting of SIR1 protein establishes transcriptional silencing at HM loci and telomeres in yeast

David Shore, D. Shore, C. Chien, 1993, Cell.

Elimination of false positives that arise in using the two-hybrid system.

S. Fields, C. Chien, P. Bartel, 1993, BioTechniques.

DEN1 deneddylates non-cullin proteins in vivo

C. Chien, K. Pan, J. Yim, 2008, Journal of Cell Science.

Protection of cullin-RING E3 ligases by CSN-UBP12.

C. Chien, June-Tai Wu, Yaru Chan, 2006, Trends in cell biology.

Neddylation and deneddylation regulate Cul1 and Cul3 protein accumulation

C. Chien, Hsiu-Chen Lin, June-Tai Wu, 2005, Nature Cell Biology.

A dual function of phyllopod in Drosophila external sensory organ development: cell fate specification of sensory organ precursor and its progeny.

C. Chien, H. Pi, H. Wu, 2001, Development.

Nak regulates Dlg basal localization in Drosophila salivary gland cells.

C. Chien, Wei-Hsiang Lin, Yu-Huei Peng, 2009, Biochemical and biophysical research communications.

The hypoparathyroidism-associated mutation in Drosophila Gcm compromises protein stability and glial cell formation

C. Chien, B. Tan, Xuebing Chen, 2017, Scientific Reports.

Gcm protein degradation suppresses proliferation of glial progenitors

C. Chien, A. Giangrande, Hungwen Chen, 2009, Proceedings of the National Academy of Sciences.

The COP9 Signalosome Converts Temporal Hormone Signaling to Spatial Restriction on Neural Competence

C. Chien, H. Pi, June-Tai Wu, 2014, PLoS genetics.

CSN-mediated deneddylation differentially modulates Ci155 proteolysis to promote Hedgehog signalling responses

Wei-Hsiang Lin, Cheng-Ting Chien, June-Tai Wu, 2011, Nature communications.

Cul1 and Cul3 Mediate Distinct Protein Degradation Mechanisms to Control Ci Stability in Drosophila Eye Development

C. Chien, C. Ou, Ying-Jiun C. Chen, 2002 .

Glial response to hypoxia in mutants of NPAS1/3 homolog Trachealess through Wg signaling to modulate synaptic bouton organization

C. Chien, A. Giangrande, Ying-Ju Cheng, 2019, PLoS genetics.

Cul4 and DDB1 regulate Orc2 localization, BrdU incorporation and Dup stability during gene amplification in Drosophila follicle cells

C. Chien, B. Tan, Hsiu-Chen Lin, 2009, Journal of Cell Science.

Lovastatin protects neurite degeneration in LRRK2-G2019S parkinsonism through activating the Akt/Nrf pathway and inhibiting GSK3β activity.

C. Chien, R. Wu, M. Farrer, 2016, Human molecular genetics.

RNAi Induced Wing Modification in Leon Mutant Drosophila Females: Exploring the Tissue Specificity and Physiological Interference

C. Chien, eep Satapathy, 2013 .

Neurofibromin Mediates FAK Signaling in Confining Synapse Growth at Drosophila Neuromuscular Junctions

C. Chien, Ruey-Hwa Chen, Ying-Ju Cheng, 2012, The Journal of Neuroscience.

Epidermis-Derived L1CAM Homolog Neuroglian Mediates Dendrite Enclosure and Blocks Heteroneuronal Dendrite Bundling

C. Chien, Jan Pielage, Ying-Ju Cheng, 2019, Current Biology.

Fringe-positive Golgi outposts unite temporal Furin 2 convertase activity and spatial Delta signal to promote dendritic branch retraction.

C. Chien, E. Giniger, H. Pi, 2022, Cell reports.

The deubiquitinase Leon/USP5 regulates ubiquitin homeostasis during Drosophila development.

C. Chien, Guang-Chao Chen, Chien-Hsiang Wang, 2014, Biochemical and biophysical research communications.

Gastrodia elata Blume prevents dopaminergic neuron degeneration via glial Nrf2 signaling in Lrrk2-G2019S Parkinson’s disease models

C. Chien, C. Elliott, L. Sheen, 2021, bioRxiv.

RNAI INDUCED WING MODIFICATION IN LEON MUTANT DROSOPHILA : A DEVELOPMENTAL ANALYSIS

C. Chien, S. Satapathy, 2013 .

Molecular Pathways Involved in LRRK2-Linked Parkinson’s Disease: A Systematic Review

C. Chien, Shi-Ruo Tong, Yu-En Lin, 2022, International journal of molecular sciences.

Hearing lessons from flies

C. Chien, Yi-Nan Lee, 2016, eLife.

Dynamic expression and cellular localization of the Drosophila 14-3-3ϵ during embryonic development

C. Chien, A. Tien, Hsin-Yin Hsei, 1999, Mechanisms of Development.

phyllopod is a target gene of proneural proteins in Drosophila external sensory organ development.

C. Chien, Shao-Kuei Huang, H. Pi, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Effect of Hibiscus anthocyanins-rich extract induces apoptosis of proliferating smooth muscle cell via activation of P38 MAPK and p53 pathway.

C. Chien, Hui-Pei Huang, Chau-Jong Wang, 2007, Molecular nutrition & food research.

Glial cell adhesive molecule unzipped mediates axon guidance in Drosophila

C. Chien, Jaulang Hwang, Ying-Hsuan Wang, 2011, Developmental dynamics : an official publication of the American Association of Anatomists.

Foxp2 Controls Synaptic Wiring of Corticostriatal Circuits and Vocal Communication by Opposing Mef2C

Hiroshi Takahashi, Ann M. Graybiel, Yi-Chuan Chen, 2016, Nature Neuroscience.

Foxp 2 controls synaptic wiring of corticostriatal circuits and vocal communication by opposing Mef 2 c

A. Graybiel, S. Pääbo, Yi-Chuan Chen, 2016 .

Spatially controlled expression of the Drosophila pseudouridine synthase RluA-1.

C. Chien, Chung-chi Wang, J. Lo, 2011, The International journal of developmental biology.

Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development.

Cheng-Ting Chien, C. Chien, C. Ou, 2002, Genes & development.

Getting the edge: neural precursor selection.

C. Chien, H. Pi, 2007, Journal of biomedical science.

Glia-derived exosomal miR-274 targets Sprouty in trachea and synaptic boutons to modulate growth and responses to hypoxia

C. Chien, Jian-Chiuan Li, Hsin-Ho Sung, 2019, Proceedings of the National Academy of Sciences.

Cell-Autonomous Regulation of Dendrite Self-Avoidance by the Wnt Secretory Factor MIG-14/Wntless

C. Chien, Hsiu-Hsiang Lee, Chun-Liang Pan, 2018, Neuron.

Suppression of Hedgehog signaling by Cul3 ligases in proliferation control of retinal precursors.

Chien-Hsiang Wang, Cheng-Ting Chien, C. Chien, 2007, Developmental biology.

Network Modeling of Drosophila External Sensory Organ Precursor Formation: The Role of Recently Studied Genes

C. Chien, Chao‐Ping Hsu, H. Pi, 2003 .

Beyond being innervated: the epidermis actively shapes sensory dendritic patterning

C. Chien, Wei-Kang Yang, 2019, Open Biology.

Functional cooperation between FACT and MCM helicase facilitates initiation of chromatin DNA replication

C. Chien, Sheng‐Chung Lee, B. Tan, 2006, The EMBO journal.

The utility F-box for protein destruction

C. Chien, H. Pi, C. Ou, 2008, Cellular and Molecular Life Sciences.

Transcriptional activation upon pheromone stimulation mediated by a small domain of Saccharomyces cerevisiae Ste12p

S. Fields, C. Chien, H. Pi, 1997, Molecular and cellular biology.

Expression of rat hepatic glucokinase in Escherichia coli.

C. Chien, R. Printz, D. Granner, 1989, Biochemical and biophysical research communications.

The POU‐domain protein Pdm3 regulates axonal targeting of R neurons in the Drosophila ellipsoid body

C. Chien, Wei-yu Chen, Chien-Kuo Chen, 2012, Developmental neurobiology.

Effect of alisol B acetate, a plant triterpene, on apoptosis in vascular smooth muscle cells and lymphocytes.

C. Chien, M. Hsu, H. W. Chen, 2001, European journal of pharmacology.

Glial response to hypoxia in trachealess mutants induces synapse remodeling

C. Chien, A. Giangrande, Yi-Wei Tsai, 2019, bioRxiv.

Cell cycle roles for two 14-3-3 proteins during Drosophila development.

P. O’Farrell, C. Chien, T. T. Su, 2001, Journal of cell science.

Control of protein degradation by E3 ubiquitin ligases in Drosophila eye development.

Cheng-Ting Chien, C. Chien, H. Pi, 2003, Trends in genetics : TIG.

F-box proteins: the key to protein degradation.

Cheng-Ting Chien, C. Chien, Margaret S Ho, 2006, Journal of biomedical science.

Numb-Associated Kinase Interacts with the Phosphotyrosine Binding Domain of Numb and Antagonizes the Function of Numb In Vivo

Y. Jan, C. Chien, L. Y. Jan, 1998, Molecular and Cellular Biology.

LRRK2 G2019S Mutation Induces Dendrite Degeneration through Mislocalization and Phosphorylation of Tau by Recruiting Autoactivated GSK3β

C. Chien, R. Wu, Chin-Hsien Lin, 2010, The Journal of Neuroscience.

LRRK2 Parkinson’s disease: from animal models to cellular mechanisms

C. Chien, R. Wu, Chin-Hsien Lin, 2011, Reviews in the neurosciences.

Lrrk regulates the dynamic profile of dendritic Golgi outposts through the golgin Lava lamp

C. Chien, R. Wu, Chin-Hsien Lin, 2015, The Journal of cell biology.

Nak Regulates Localization of Clathrin Sites in Higher-Order Dendrites to Promote Local Dendrite Growth

Henry C. Chang, C. Chien, Yu Lin, 2011, Neuron.

The Proto-Oncogene Int6 Is Essential for Neddylation of Cul1 and Cul3 in Drosophila

C. Chien, D. Chamovitz, D. Segal, 2008, PloS one.

USP5/Leon deubiquitinase confines postsynaptic growth by maintaining ubiquitin homeostasis through Ubiquilin

C. Chien, H. Pi, Ying-Ju Cheng, 2017, eLife.

Activity-dependent retrograde laminin A signaling regulates synapse growth at Drosophila neuromuscular junctions

C. Chien, Ruey-Hwa Chen, Ying-Ju Cheng, 2012, Proceedings of the National Academy of Sciences.

The COP9 Signalosome Is Required for Light-Dependent Timeless Degradation and Drosophila Clock Resetting

C. Chien, D. Chamovitz, J. Blau, 2009, The Journal of Neuroscience.

DAPK activates MARK1/2 to regulate microtubule assembly, neuronal differentiation, and tau toxicity

C. Chien, A. Kimchi, G-C Chen, 2011, Cell Death and Differentiation.

Fak56 functions downstream of integrin alphaPS3betanu and suppresses MAPK activation in neuromuscular junction growth

C. Chien, R. Palmer, D. Van Vactor, 2008, Neural Development.

Actin blobs prefigure dendrite branching sites

C. Chien, Vanitha Nithianandam, 2018, The Journal of cell biology.

Glial Nrf2 signaling mediates the neuroprotection exerted by Gastrodia elata Blume in Lrrk2-G2019S Parkinson’s disease

C. Chien, C. Elliott, L. Sheen, 2021, eLife.

Scabrous controls ommatidial rotation in the Drosophila compound eye.

Cheng-Ting Chien, Ya-Hui Chou, C. Chien, 2002, Developmental cell.

Dbo/Henji Modulates Synaptic dPAK to Gate Glutamate Receptor Abundance and Postsynaptic Response

C. Chien, Ying-Ju Cheng, Tzu-Ting Lai, 2016, PLoS genetics.

Neuronal type information encoded in the basic-helix-loop-helix domain of proneural genes.

Y. Jan, L. Jan, C. Chien, 1996, Proceedings of the National Academy of Sciences of the United States of America.

The Proneural Gene amos Promotes Multiple Dendritic Neuron Formation in the Drosophila Peripheral Nervous System

C. Chien, Min-Lang Huang, Chia-Hsin Hsu, 2000, Neuron.

Negative regulation of atonal in proneural cluster formation of Drosophila R8 photoreceptors.

C. Chien, C T Chien, C K Chen, 1999, Proceedings of the National Academy of Sciences of the United States of America.

The deubiquitinase Leon/USP5 interacts with Atg1/ULK1 and antagonizes autophagy

C. Chien, Guang-Chao Chen, H. Chou, 2023, Cell death & disease.

The p53 target Wig-1: a regulator of mRNA stability and stem cell fate?

C. Chien, A. Kimchi, K. Wiman, 2011, Cell Death and Differentiation.

F-box proteins: the key to protein degradation.

C. Chien, M. Ho, P. Tsai, 2006, Journal of biomedical science.

LRRK2 G2019S Mutation Induces Dendrite Degeneration through Mislocalization and Phosphorylation of Tau by Recruiting Autoactivated GSK3β

C. Chien, R. Wu, Chin-Hsien Lin, 2010, The Journal of Neuroscience.